ID 1A01_GORGO Reviewed; 365 AA. AC P30375; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 28-FEB-2018, entry version 95. DE RecName: Full=Class I histocompatibility antigen, Gogo-A*0101 alpha chain; DE Flags: Precursor; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1744581; DOI=10.1084/jem.174.6.1491; RA Lawlor D.A., Warren E., Taylor P., Parham P.; RT "Gorilla class I major histocompatibility complex alleles: comparison RT to human and chimpanzee class I."; RL J. Exp. Med. 174:1491-1509(1991). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X60258; CAA42810.1; -; mRNA. DR PIR; JH0534; JH0534. DR ProteinModelPortal; P30375; -. DR SMR; P30375; -. DR PRIDE; P30375; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000001519; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 365 Class I histocompatibility antigen, Gogo- FT A*0101 alpha chain. FT /FTId=PRO_0000018897. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000250|UniProtKB:P30443}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000250|UniProtKB:P30443}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000250|UniProtKB:P30443}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 365 AA; 40830 MW; FB1B14BCD4DF63A8 CRC64; MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAHSQTDRV DLGTLRGYYN QSEDGSHTIQ RMYGCDVGSD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAEITKRK WEAAHFAEQL RAYLEGTCVE WLRRHLENGK ETLQRTDAPK THMTHHAVSD HEAILRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDVSL TACKV // ID 1A01_HUMAN Reviewed; 365 AA. AC P30443; O77964; O78171; Q9MYA3; Q9TP25; Q9TQP5; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 167. DE RecName: Full=HLA class I histocompatibility antigen, A-1 alpha chain; DE AltName: Full=MHC class I antigen A*1; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE A*01:01). RX PubMed=3375250; DOI=10.1073/pnas.85.11.4005; RA Parham P., Lomen C.E., Lawlor D.A., Ways J.P., Holmes N., Coppin H.L., RA Salter R.D., Wan A.M., Ennis P.D.; RT "Nature of polymorphism in HLA-A, -B, and -C molecules."; RL Proc. Natl. Acad. Sci. U.S.A. 85:4005-4009(1988). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE A*01:01). RX PubMed=2715640; RA Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.; RT "Diversity and diversification of HLA-A,B,C alleles."; RL J. Immunol. 142:3937-3950(1989). RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE A*01:01). RA Warren E.; RL Submitted (APR-1989) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*01:01). RX PubMed=2251137; DOI=10.1093/nar/18.22.6701; RA Girdlestone J.; RT "Nucleotide sequence of an HLA-A1 gene."; RL Nucleic Acids Res. 18:6701-6701(1990). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*01:01). RX PubMed=9349617; DOI=10.1111/j.1399-0039.1997.tb02885.x; RA Laforet M., Froelich N., Parissiadis A., Pfeiffer B., Schell A., RA Faller B., Woehl-Jaegle M.L., Cazenave J.-P., Tongio M.M.; RT "A nucleotide insertion in exon 4 is responsible for the absence of RT expression of an HLA-A*01 allele."; RL Tissue Antigens 50:347-350(1997). RN [6] RP NUCLEOTIDE SEQUENCE (ALLELE A*01:01). RA Waller M.J., Robinson J., Marsh S.G.E.; RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE A*01:01). RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*01:02). RX PubMed=7761977; DOI=10.1111/j.1399-0039.1995.tb02437.x; RA Browning M.J., Madrigal J.A., Krausa P., Kowalski H., Allsopp C.E., RA Little A.-M., Turner S., Adams E.J., Arnett K.L., Bodmer W.F., RA Parham P.; RT "The HLA-A,B,C genotype of the class I negative cell line Daudi RT reveals novel HLA-A and -B alleles."; RL Tissue Antigens 45:177-187(1995). RN [9] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*01:03). RX PubMed=9438203; DOI=10.1016/S0198-8859(97)00204-8; RA Sitha S., Scheltinga S.A., Johnston-Dow L.A., White C.B., RA der van Zwan A.W., Bakema J.E., Rozemuller E.H., van der Tweel J.G., RA Kronink M.N., Tilanus M.G.J.; RT "A generic sequencing based typing approach for the identification of RT HLA-A diversity."; RL Hum. Immunol. 57:120-128(1997). RN [10] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*01:03). RC TISSUE=Blood; RX PubMed=11182232; DOI=10.1016/S0198-8859(00)00238-X; RA Poland G.A., Sohni Y., Domanico M., Kroning C.M., DeGoey S.R., RA Jimale M., Jacobson R.M., Moore S.B.; RT "High frequency of HLA-A*0103 allele in a Somali population."; RL Hum. Immunol. 62:197-200(2001). RN [11] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*01:06). RX PubMed=10852390; DOI=10.1034/j.1399-0039.2000.550412.x; RA Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R., RA Ng J., Hartzman R.J., Hurley C.K.; RT "Seventeen more novel HLA-A locus alleles."; RL Tissue Antigens 55:369-373(2000). RN [12] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*01:07). RA Tamouza R., Fortier C., Mahfoudh N., Schaeffer V., Poirier J.C., RA Marzais F., Gautreau C., Charron D.; RT "A new HLA-A*01 allele."; RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases. RN [13] RP SULFATION. RX PubMed=3121736; RA Sant A.J., Zacheis M., Rumbarger T., Giacoletto K.S., Schwartz B.D.; RT "Human Ia alpha- and beta-chains are sulfated."; RL J. Immunol. 140:155-160(1988). RN [14] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110. RC TISSUE=Liver; RX PubMed=19159218; DOI=10.1021/pr8008012; RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; RT "Glycoproteomics analysis of human liver tissue by combination of RT multiple enzyme digestion and hydrazide chemistry."; RL J. Proteome Res. 8:651-661(2009). RN [15] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352; SER-356 AND RP SER-359, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [16] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [17] RP X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 25-298 IN COMPLEX WITH MAGE RP ANTIGENIC PEPTIDE AND ANTIBODY, AND DISULFIDE BONDS. RX PubMed=15537658; DOI=10.1074/jbc.M411323200; RA Hulsmeyer M., Chames P., Hillig R.C., Stanfield R.L., Held G., RA Coulie P.G., Alings C., Wille G., Saenger W., Uchanska-Ziegler B., RA Hoogenboom H.R., Ziegler A.; RT "A major histocompatibility complex-peptide-restricted antibody and t RT cell receptor molecules recognize their target by distinct binding RT modes: crystal structure of human leukocyte antigen (HLA)-A1-MAGE-A1 RT in complex with FAB-HYB3."; RL J. Biol. Chem. 280:2972-2980(2005). RN [18] RP VARIANT [LARGE SCALE ANALYSIS] THR-166, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). Interacts with human herpesvirus 8 MIR1 protein CC (By similarity). {ECO:0000250}. CC -!- INTERACTION: CC Q14943:KIR3DS1; NbExp=2; IntAct=EBI-8561769, EBI-15316524; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Sulfated. {ECO:0000269|PubMed:3121736}. CC -!- PTM: Polyubiquitinated in a post ER compartment through CC interaction with human herpesvirus 8 MIR1 protein. This targets CC the protein for rapid degradation via the ubiquitin system (By CC similarity). {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of A-1 are known: A*01:01, CC A*01:02, A*01:03, A*01:06 and A*01:07. The sequence shown is that CC of A*01:01. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M24043; AAA59652.1; -; Genomic_DNA. DR EMBL; X55710; CAA39243.1; -; Genomic_DNA. DR EMBL; Z93949; CAB07989.1; -; Genomic_DNA. DR EMBL; AJ278305; CAB93537.1; -; Genomic_DNA. DR EMBL; BC003069; AAH03069.1; -; mRNA. DR EMBL; U07161; AAA80569.1; -; mRNA. DR EMBL; Y12469; CAA73072.1; -; Genomic_DNA. DR EMBL; Y12470; CAA73073.1; -; Genomic_DNA. DR EMBL; AH008863; AAF19525.1; -; Genomic_DNA. DR EMBL; AH007762; AAD33894.1; -; Genomic_DNA. DR EMBL; AH009407; AAF73862.1; -; Genomic_DNA. DR PIR; I38518; I38518. DR PIR; I61856; I61856. DR RefSeq; NP_001229687.1; NM_001242758.1. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR PDB; 1W72; X-ray; 2.15 A; A/D=25-298. DR PDB; 3BO8; X-ray; 1.80 A; A=25-298. DR PDB; 4NQV; X-ray; 2.39 A; A/C/E/G/I/K=25-298. DR PDB; 4NQX; X-ray; 2.00 A; A/C/E/G/I/K=25-308. DR PDB; 5BRZ; X-ray; 2.62 A; A=25-298. DR PDB; 5BS0; X-ray; 2.40 A; A=25-298. DR PDB; 6AT9; X-ray; 2.95 A; A=25-304. DR PDBsum; 1W72; -. DR PDBsum; 3BO8; -. DR PDBsum; 4NQV; -. DR PDBsum; 4NQX; -. DR PDBsum; 5BRZ; -. DR PDBsum; 5BS0; -. DR PDBsum; 6AT9; -. DR ProteinModelPortal; P30443; -. DR SMR; P30443; -. DR BioGrid; 109350; 90. DR IntAct; P30443; 8. DR MINT; P30443; -. DR iPTMnet; P30443; -. DR PhosphoSitePlus; P30443; -. DR SwissPalm; P30443; -. DR DMDM; 231347; -. DR PeptideAtlas; P30443; -. DR PRIDE; P30443; -. DR DNASU; 3105; -. DR Ensembl; ENST00000431930; ENSP00000406366; ENSG00000229215. DR Ensembl; ENST00000443552; ENSP00000404678; ENSG00000224320. DR Ensembl; ENST00000549869; ENSP00000447635; ENSG00000224320. DR Ensembl; ENST00000552193; ENSP00000447614; ENSG00000229215. DR GeneID; 3105; -. DR KEGG; hsa:3105; -. DR CTD; 3105; -. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P30443; -. DR Orphanet; 179; Birdshot chorioretinopathy. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR SIGNOR; P30443; -. DR ChiTaRS; HLA-A; human. DR EvolutionaryTrace; P30443; -. DR GenomeRNAi; 3105; -. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB. DR GO; GO:0016020; C:membrane; HDA:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0046977; F:TAP binding; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0016045; P:detection of bacterium; IMP:UniProtKB. DR GO; GO:0006955; P:immune response; IMP:UniProtKB. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR GO; GO:0016032; P:viral process; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Host-virus interaction; Immunity; Immunoglobulin domain; Membrane; KW MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Sulfation; Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-1 alpha chain. FT /FTId=PRO_0000018813. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 83 83 Sulfotyrosine. {ECO:0000255}. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:19159218}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:15537658}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:15537658}. FT VARIANT 33 33 F -> S (in allele A*01:02; FT dbSNP:rs2075684). FT {ECO:0000269|PubMed:7761977}. FT /FTId=VAR_004332. FT VARIANT 41 41 R -> S (in allele A*01:02; FT dbSNP:rs1059423). FT {ECO:0000269|PubMed:7761977}. FT /FTId=VAR_004333. FT VARIANT 80 80 G -> R (in allele A*01:07; FT dbSNP:rs1059449). {ECO:0000269|Ref.12}. FT /FTId=VAR_016719. FT VARIANT 89 89 R -> G (in dbSNP:rs199474430). FT {ECO:0000269|Ref.12}. FT /FTId=VAR_056247. FT VARIANT 91 91 M -> V (in allele A*01:07; FT dbSNP:rs79361534). {ECO:0000269|Ref.12}. FT /FTId=VAR_016720. FT VARIANT 100 100 A -> E (in allele A*01:07; FT dbSNP:rs1071742). {ECO:0000269|Ref.12}. FT /FTId=VAR_016721. FT VARIANT 114 114 D -> A (in allele A*01:07; FT dbSNP:rs1136692). {ECO:0000269|Ref.12}. FT /FTId=VAR_016722. FT VARIANT 121 121 I -> M (in allele A*01:03; FT dbSNP:rs1136695). FT {ECO:0000269|PubMed:11182232, FT ECO:0000269|PubMed:9438203}. FT /FTId=VAR_016723. FT VARIANT 131 131 G -> W (in dbSNP:rs1136702). FT /FTId=VAR_056248. FT VARIANT 133 133 F -> L (in dbSNP:rs1059488). FT /FTId=VAR_056249. FT VARIANT 151 151 N -> K (in dbSNP:rs1059509). FT /FTId=VAR_056250. FT VARIANT 166 166 I -> T (in dbSNP:rs1059516). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056251. FT VARIANT 169 169 R -> H (in dbSNP:rs1059520). FT /FTId=VAR_056252. FT VARIANT 180 180 R -> L (in allele A*01:06; FT dbSNP:rs9260156). FT {ECO:0000269|PubMed:10852390}. FT /FTId=VAR_016724. FT VARIANT 182 182 V -> A (in allele A*01:06; FT dbSNP:rs9260157). FT {ECO:0000269|PubMed:10852390}. FT /FTId=VAR_016725. FT VARIANT 205 205 R -> H (in dbSNP:rs17185861). FT /FTId=VAR_056253. FT STRAND 27 36 {ECO:0000244|PDB:3BO8}. FT STRAND 41 43 {ECO:0000244|PDB:3BO8}. FT STRAND 45 52 {ECO:0000244|PDB:3BO8}. FT STRAND 55 61 {ECO:0000244|PDB:3BO8}. FT STRAND 64 66 {ECO:0000244|PDB:3BO8}. FT STRAND 70 73 {ECO:0000244|PDB:1W72}. FT HELIX 74 76 {ECO:0000244|PDB:3BO8}. FT HELIX 81 109 {ECO:0000244|PDB:3BO8}. FT STRAND 113 115 {ECO:0000244|PDB:1W72}. FT STRAND 118 127 {ECO:0000244|PDB:3BO8}. FT STRAND 133 142 {ECO:0000244|PDB:3BO8}. FT STRAND 145 150 {ECO:0000244|PDB:3BO8}. FT STRAND 157 159 {ECO:0000244|PDB:3BO8}. FT HELIX 162 173 {ECO:0000244|PDB:3BO8}. FT HELIX 176 185 {ECO:0000244|PDB:3BO8}. FT HELIX 187 198 {ECO:0000244|PDB:3BO8}. FT HELIX 200 203 {ECO:0000244|PDB:3BO8}. FT STRAND 210 217 {ECO:0000244|PDB:3BO8}. FT STRAND 219 235 {ECO:0000244|PDB:3BO8}. FT STRAND 238 243 {ECO:0000244|PDB:3BO8}. FT STRAND 246 248 {ECO:0000244|PDB:4NQX}. FT HELIX 249 251 {ECO:0000244|PDB:3BO8}. FT STRAND 252 254 {ECO:0000244|PDB:4NQX}. FT STRAND 261 263 {ECO:0000244|PDB:3BO8}. FT STRAND 265 274 {ECO:0000244|PDB:3BO8}. FT HELIX 278 280 {ECO:0000244|PDB:3BO8}. FT STRAND 281 286 {ECO:0000244|PDB:3BO8}. FT STRAND 290 292 {ECO:0000244|PDB:4NQX}. FT STRAND 294 296 {ECO:0000244|PDB:3BO8}. SQ SEQUENCE 365 AA; 40846 MW; 8667AFF3F06C4932 CRC64; MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQKME PRAPWIEQEG PEYWDQETRN MKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAVHAAEQR RVYLEGRCVD GLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL TACKV // ID 1A01_PANTR Reviewed; 365 AA. AC P16209; Q549C1; DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1990, sequence version 1. DT 18-JUL-2018, entry version 105. DE RecName: Full=Patr class I histocompatibility antigen, A-2 alpha chain; DE AltName: Full=ChLa class I histocompatibility antigen, A-2 alpha chain; DE Flags: Precursor; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1690682; DOI=10.1111/j.1600-065X.1990.tb00040.x; RA Lawlor D.A., Warren E., Ward F.E., Parham P.; RT "Comparison of class I MHC alleles in humans and apes."; RL Immunol. Rev. 113:147-185(1990). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Blood; RX PubMed=10866106; DOI=10.1007/s002510050638; RA de Groot N.G., Otting N., Arguello R., Watkins D.I., Doxiadis G.G., RA Madrigal J.A., Bontrop R.E.; RT "Major histocompatibility complex class I diversity in a West African RT chimpanzee population: implications for HIV research."; RL Immunogenetics 51:398-409(2000). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M30678; AAA87970.1; -; mRNA. DR EMBL; AF168394; AAF72775.1; -; mRNA. DR PIR; I36961; I36961. DR UniGene; Ptr.2590; -. DR ProteinModelPortal; P16209; -. DR SMR; P16209; -. DR PRIDE; P16209; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000002277; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 365 Patr class I histocompatibility antigen, FT A-2 alpha chain. FT /FTId=PRO_0000018910. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000250|UniProtKB:P30443}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000250|UniProtKB:P30443}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000250|UniProtKB:P30443}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 365 AA; 40849 MW; FC452786BD038D3E CRC64; MAVMPPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDEETRS AKAHSQTDRV DLGTLRGYYN QSEDGSHTIQ IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAAHAAEQR RAYLEGTCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL TACKV // ID 1A02_GORGO Reviewed; 365 AA. AC P30376; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 28-FEB-2018, entry version 93. DE RecName: Full=Class I histocompatibility antigen, Gogo-A*0201 alpha chain; DE Flags: Precursor; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1744581; DOI=10.1084/jem.174.6.1491; RA Lawlor D.A., Warren E., Taylor P., Parham P.; RT "Gorilla class I major histocompatibility complex alleles: comparison RT to human and chimpanzee class I."; RL J. Exp. Med. 174:1491-1509(1991). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X60259; CAA42811.1; -; mRNA. DR PIR; JH0535; JH0535. DR ProteinModelPortal; P30376; -. DR SMR; P30376; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000001519; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 365 Class I histocompatibility antigen, Gogo- FT A*0201 alpha chain. FT /FTId=PRO_0000018898. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 365 AA; 40896 MW; 09E0E5FCD8E58507 CRC64; MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEE PEYWDGETRK VKAHSQTDRV NLGTLRGYYN QSEAGSHTIQ KMYGCDVGSD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAEITKRK WEAAHFAEQL RAYLEGECVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEAILRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHESL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VIAGAVIAAV RWRRKSSDRK GGSYSQAASS DSAQGSDVSL TACKV // ID 1A02_HUMAN Reviewed; 365 AA. AC P01892; O19619; P06338; P10313; P30444; P30445; P30446; P30514; AC Q29680; Q29837; Q29899; Q95352; Q95380; Q9TPX8; Q9TPX9; Q9TPY0; AC Q9TQH5; Q9TQI3; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 13-AUG-1987, sequence version 1. DT 12-SEP-2018, entry version 212. DE RecName: Full=HLA class I histocompatibility antigen, A-2 alpha chain; DE AltName: Full=MHC class I antigen A*2; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*02:01). RX PubMed=2982951; RA Koller B.H., Orr H.T.; RT "Cloning and complete sequence of an HLA-A2 gene: analysis of two HLA- RT A alleles at the nucleotide level."; RL J. Immunol. 134:2727-2733(1985). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE A*02:01). RX PubMed=2914713; DOI=10.1007/BF00395855; RA Cianetti L., Testa U., Scotto L., la Valle R., Simeone A., Boccoli G., RA Giannella G., Peschle C., Boncinelli E.; RT "Three new class I HLA alleles: structure of mRNAs and alternative RT mechanisms of processing."; RL Immunogenetics 29:80-91(1989). RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE A*02:01). RX PubMed=2320591; DOI=10.1073/pnas.87.7.2833; RA Ennis P.D., Zemmour J., Salter R.D., Parham P.; RT "Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: RT frequency and nature of errors produced in amplification."; RL Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] OF 91-365. RX PubMed=3863816; RA Davidson W.F., Kress M., Khoury G., Jay G.; RT "Comparison of HLA class I gene sequences. Derivation of locus- RT specific oligonucleotide probes specific for HLA-A, HLA-B, and HLA-C RT genes."; RL J. Biol. Chem. 260:13414-13423(1985). RN [5] RP NUCLEOTIDE SEQUENCE (ALLELES A*02:01; A*02:11 AND A*02:12). RX PubMed=1317015; DOI=10.1038/357326a0; RA Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J., RA Williams R.C., Luz R., Petzl-Erler M.L., Parham P.; RT "Unusual HLA-B alleles in two tribes of Brazilian Indians."; RL Nature 357:326-329(1992). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] OF 39-365 (ALLELE A*02:01). RX PubMed=3874058; RA Krangel M.S.; RT "Unusual RNA splicing generates a secreted form of HLA-A2 in a RT mutagenized B lymphoblastoid cell line."; RL EMBO J. 4:1205-1210(1985). RN [7] RP PROTEIN SEQUENCE OF 25-295 (ALLELE A*02:01). RX PubMed=92029; DOI=10.1073/pnas.76.9.4395; RA Orr H.T., Lopez de Castro J.A., Parham P., Ploegh H.L., RA Strominger J.L.; RT "Comparison of amino acid sequences of two human histocompatibility RT antigens, HLA-A2 and HLA-B7: location of putative alloantigenic RT sites."; RL Proc. Natl. Acad. Sci. U.S.A. 76:4395-4399(1979). RN [8] RP SEQUENCE REVISION (ALLELE A*02:01). RX PubMed=6179086; DOI=10.1073/pnas.79.12.3813; RA Lopez de Castro J.A., Strominger J.L., Strong D.M., Orr H.T.; RT "Structure of crossreactive human histocompatibility antigens HLA-A28 RT and HLA-A2: possible implications for the generation of HLA RT polymorphism."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3813-3817(1982). RN [9] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*02:01). RC TISSUE=Blood; RX PubMed=7836067; DOI=10.1016/0198-8859(94)90087-6; RA Balas A., Garcia-Sanchez F., Gomez-Reino F., Vicario J.L.; RT "HLA class I allele (HLA-A2) expression defect associated with a RT mutation in its enhancer B inverted CAT box in two families."; RL Hum. Immunol. 41:69-73(1994). RN [10] RP SEQUENCE REVISION. RA Balas A.; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. RN [11] RP NUCLEOTIDE SEQUENCE (ALLELE A*02:01). RA Cox S.T.; RT "Confirmation of HLA-A*0201."; RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases. RN [12] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-298 (ALLELES A*02:02 AND RP A*02:03). RX PubMed=3497874; DOI=10.1007/BF00365911; RA Mattson D.H., Handy D.E., Bradley D.A., Coligan J.E., Cowan E.P., RA Biddison W.E.; RT "DNA sequences of the genes that encode the CTL-defined HLA-A2 RT variants M7 and DK1."; RL Immunogenetics 26:190-192(1987). RN [13] RP NUCLEOTIDE SEQUENCE (ALLELES A*02:03 AND A*02:05). RX PubMed=3496393; RA Holmes N., Ennis P., Wan A.M., Denney D.W., Parham P.; RT "Multiple genetic mechanisms have contributed to the generation of the RT HLA-A2/A28 family of class I MHC molecules."; RL J. Immunol. 139:936-941(1987). RN [14] RP NUCLEOTIDE SEQUENCE (ALLELES A*02:03 AND A*02:05). RA Domena J.D.; RL Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases. RN [15] RP NUCLEOTIDE SEQUENCE [MRNA] OF 9-365 (ALLELE A*02:04). RX PubMed=1937577; DOI=10.1007/BF00211991; RA Castano A.R., Lopez de Castro J.A.; RT "Structure of the HLA-A*0204 antigen, found in South American Indians. RT Spatial clustering of HLA-A2 subtype polymorphism."; RL Immunogenetics 34:281-285(1991). RN [16] RP NUCLEOTIDE SEQUENCE OF 9-365 (ALLELE A*02:04). RX PubMed=1589035; DOI=10.1038/357329a0; RA Watkins D.I., McAdam S.N., Liu X., Stang C.R., Milford E.L., RA Levine C.G., Garber T.L., Dogon A.L., Lord C.I., Ghim S.H., RA Troup G.M., Hughes A.L., Letvin N.L.; RT "New recombinant HLA-B alleles in a tribe of South American RT Amerindians indicate rapid evolution of MHC class I loci."; RL Nature 357:329-333(1992). RN [17] RP NUCLEOTIDE SEQUENCE (ALLELE A*02:06). RX PubMed=2715640; RA Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.; RT "Diversity and diversification of HLA-A,B,C alleles."; RL J. Immunol. 142:3937-3950(1989). RN [18] RP PARTIAL PROTEIN SEQUENCE (ALLELE A*02:06). RX PubMed=3489037; RA Ezquerra A., Domenech N., van der Poel J., Strominger J.L., Vega M.A., RA Lopez de Castro J.A.; RT "Molecular analysis of an HLA-A2 functional variant CLA defined by RT cytolytic T lymphocytes."; RL J. Immunol. 137:1642-1649(1986). RN [19] RP PARTIAL PROTEIN SEQUENCE (ALLELE A*02:07). RX PubMed=2448239; DOI=10.1007/BF00346586; RA Domenech N., Ezquerra A., Castano R., Lopez de Castro J.A.; RT "Structural analysis of HLA-A2.4 functional variant KNE. Implications RT for the mapping of HLA-A2-specific T-cell epitopes."; RL Immunogenetics 27:196-202(1988). RN [20] RP PARTIAL PROTEIN SEQUENCE (ALLELE A*02:08). RX PubMed=2457548; DOI=10.1007/BF00375853; RA Domenech N., Castano R., Goulmy E., Lopez de Castro J.A.; RT "Molecular analysis of HLA-A2.4 functional variant KLO: close RT structural and evolutionary relatedness to the HLA-A2.2 subtype."; RL Immunogenetics 28:143-152(1988). RN [21] RP PARTIAL PROTEIN SEQUENCE (ALLELE A*02:09). RX PubMed=3258580; DOI=10.1007/BF00395130; RA Castano R., Ezquerra A., Domenech N., Lopez de Castro J.A.; RT "An HLA-A2 population variant with structural polymorphism in the RT alpha 3 region."; RL Immunogenetics 27:345-355(1988). RN [22] RP NUCLEOTIDE SEQUENCE (ALLELE A*02:10). RX PubMed=2783680; DOI=10.1007/BF00395859; RA Epstein H., Kennedy L., Holmes N.; RT "An Oriental HLA-A2 subtype is closely related to a subset of RT Caucasoid HLA-A2 alleles."; RL Immunogenetics 29:112-116(1989). RN [23] RP NUCLEOTIDE SEQUENCE [MRNA] OF 9-365 (ALLELE A*02:11). RX PubMed=1559719; DOI=10.1007/BF00189898; RA Castano A.R., Lopez de Castro J.A.; RT "Structure of the HLA-A*0211 (A2.5) subtype: further evidence for RT selection-driven diversification of HLA-A2 antigens."; RL Immunogenetics 35:344-346(1992). RN [24] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*02:13). RX PubMed=8168863; DOI=10.1007/BF00189243; RA Barber D.F., Fernandez J.M., Lopez de Castro J.A.; RT "Primary structure of a new HLA-A2 subtype: HLA-A*0213."; RL Immunogenetics 39:378-378(1994). RN [25] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*02:16). RX PubMed=7759139; DOI=10.1007/BF00164000; RA Barouch D., Krausa P., Bodmer J., Browning M.J., McMichael A.J.; RT "Identification of a novel HLA-A2 subtype, HLA-A*0216."; RL Immunogenetics 41:388-388(1995). RN [26] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*02:17). RC TISSUE=Blood; RX PubMed=7652742; DOI=10.1111/j.1399-0039.1995.tb02464.x; RA Selvakumar A., Granja C.B., Salazar M., Alosco S.M., Yunis E.J., RA Dupont B.; RT "A novel subtype of A2 (A*0217) isolated from the South American RT Indian B-cell line AMALA."; RL Tissue Antigens 45:343-347(1995). RN [27] RP NUCLEOTIDE SEQUENCE (ALLELE A*02:18). RC TISSUE=Blood; RA Kashiwase K., Tokunaga K., Ishikawa Y., Oohashi H., Hashimoto M., RA Akaza T., Tadokoro K., Juji T.; RT "A new A2 sequence HLA-A2K from Japanese."; RL Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases. RN [28] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*02:20). RC TISSUE=Blood; RX PubMed=9008310; DOI=10.1111/j.1399-0039.1996.tb02691.x; RA Fleischhauer K., Zino E., Mazzi B., Severini G.M., Benazzi E., RA Bordignon C.; RT "HLA-A*02 subtype distribution in Caucasians from northern Italy: RT identification of A*0220."; RL Tissue Antigens 48:673-679(1996). RN [29] RP NUCLEOTIDE SEQUENCE (ALLELE A*02:21). RC TISSUE=Blood; RA Szmania S., Baxter-Lowe L.A.; RT "Nucleotide sequence of a novel HLA-A2 gene."; RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases. RN [30] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*02:31). RX PubMed=10689125; DOI=10.1016/S0198-8859(99)00155-X; RA Ellis J.M., Henson V., Slack R., Ng J., Hartzman R.J., Hurley C.K.; RT "Frequencies of HLA-A2 alleles in five U.S. population groups. RT Predominance Of A*02011 and identification of HLA-A*0231."; RL Hum. Immunol. 61:334-340(2000). RN [31] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-298 (ALLELE A*02:34). RX PubMed=10746792; DOI=10.1034/j.1399-0039.2000.550212.x; RA Moses J.H., Greville W.D., Downes J., McClenahan W., Kennedy A., RA Dunckley H.; RT "A new HLA-A*02 allele, A*0234, detected by polymerase chain reaction RT using sequence-specific primers (PCR-SSP)."; RL Tissue Antigens 55:175-177(2000). RN [32] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*02:35; A*02:36 AND A*02:37). RX PubMed=10852390; DOI=10.1034/j.1399-0039.2000.550412.x; RA Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R., RA Ng J., Hartzman R.J., Hurley C.K.; RT "Seventeen more novel HLA-A locus alleles."; RL Tissue Antigens 55:369-373(2000). RN [33] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Platelet; RX PubMed=18088087; DOI=10.1021/pr0704130; RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., RA Schuetz C., Walter U., Gambaryan S., Sickmann A.; RT "Phosphoproteome of resting human platelets."; RL J. Proteome Res. 7:526-534(2008). RN [34] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., RA Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in RT a refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [35] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110. RC TISSUE=Liver; RX PubMed=19159218; DOI=10.1021/pr8008012; RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; RT "Glycoproteomics analysis of human liver tissue by combination of RT multiple enzyme digestion and hydrazide chemistry."; RL J. Proteome Res. 8:651-661(2009). RN [36] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356 AND SER-359, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [37] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350; SER-352; SER-356 RP AND SER-359, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [38] RP X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF A*02:01. RX PubMed=3309677; DOI=10.1038/329506a0; RA Bjorkman P.J., Saper M.A., Samraoui B., Bennett W.S., Strominger J.L., RA Wiley D.C.; RT "Structure of the human class I histocompatibility antigen, HLA-A2."; RL Nature 329:506-512(1987). RN [39] RP INTERACTION WITH HTLV-1 ACCESSORY PROTEIN P12I (MICROBIAL INFECTION). RX PubMed=11390610; DOI=10.1128/JVI.75.13.6086-6094.2001; RA Johnson J.M., Nicot C., Fullen J., Ciminale V., Casareto L., RA Mulloy J.C., Jacobson S., Franchini G.; RT "Free major histocompatibility complex class I heavy chain is RT preferentially targeted for degradation by human T-cell RT leukemia/lymphotropic virus type 1 p12(I) protein."; RL J. Virol. 75:6086-6094(2001). RN [40] RP INTERACTION WITH HUMAN HERPESVIRUS 8 MIR1 PROTEIN (MICROBIAL RP INFECTION), AND UBIQUITINATION. RX PubMed=12006494; DOI=10.1093/emboj/21.10.2418; RA Hewitt E.W., Duncan L., Mufti D., Baker J., Stevenson P.G., RA Lehner P.J.; RT "Ubiquitylation of MHC class I by the K3 viral protein signals RT internalization and TSG101-dependent degradation."; RL EMBO J. 21:2418-2429(2002). RN [41] RP X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 25-300 OF HLA-A/B2M RP HETERODIMER IN COMPLEX WITH TRAC AND TRBC1, AND DISULFIDE BONDS. RX PubMed=12796775; DOI=10.1038/ni942; RA Stewart-Jones G.B.E., McMichael A.J., Bell J.I., Stuart D.I., RA Jones E.Y.; RT "A structural basis for immunodominant human T cell receptor RT recognition."; RL Nat. Immunol. 4:657-663(2003). RN [42] RP X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF A*02:01. RX PubMed=2038058; DOI=10.1016/0022-2836(91)90567-P; RA Saper M.A., Bjorkman P.J., Wiley D.C.; RT "Refined structure of the human histocompatibility antigen HLA-A2 at RT 2.6-A resolution."; RL J. Mol. Biol. 219:277-319(1991). RN [43] RP VARIANT [LARGE SCALE ANALYSIS] GLU-176, VARIANT [LARGE SCALE ANALYSIS] RP TRP-180, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [44] RP VARIANT [LARGE SCALE ANALYSIS] GLU-176, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [45] RP VARIANT GLY-89. RX PubMed=26566883; DOI=10.1136/jmedgenet-2015-103179; RA Rafiullah R., Aslamkhan M., Paramasivam N., Thiel C., Mustafa G., RA Wiemann S., Schlesner M., Wade R.C., Rappold G.A., Berkel S.; RT "Homozygous missense mutation in the LMAN2L gene segregates with RT intellectual disability in a large consanguineous Pakistani family."; RL J. Med. Genet. 53:138-144(2016). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000269|PubMed:12796775}. CC -!- SUBUNIT: (Microbial infection) Interacts with human herpesvirus 8 CC MIR1 protein. {ECO:0000269|PubMed:12006494}. CC -!- SUBUNIT: (Microbial infection) Interacts with HTLV-1 accessory CC protein p12I. {ECO:0000269|PubMed:11390610}. CC -!- INTERACTION: CC P61769:B2M; NbExp=19; IntAct=EBI-2839473, EBI-714718; CC O15533:TAPBP; NbExp=10; IntAct=EBI-2839473, EBI-874801; CC Q9BX59:TAPBPL; NbExp=17; IntAct=EBI-2839473, EBI-12017416; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment through CC interaction with human herpesvirus 8 MIR1 protein. This targets CC the protein for rapid degradation via the ubiquitin system. CC {ECO:0000269|PubMed:12006494}. CC -!- POLYMORPHISM: The following alleles of A-2 are known: A*02:01, CC A*02:02, A*02:03, A*02:04, A*02:05, A*02:06 (A2.4A), A*02:07, CC A*02:08, A*02:09, A*02:10, A*02:11 (A2.5), A*02:12, A*02:13 CC (A*02SLU), A*02:16, A*02:17, A*02:18 (A2K), A*02:19, A*02:20, CC A*02:21, A*02:31, A*02:34 (A*AAT), A*02:35, A*02:36 and A*02:37. CC The sequence shown is that of A*02:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=CAA41022.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown extensively.; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; K02883; AAA98727.1; -; Genomic_DNA. DR EMBL; M84379; AAA59606.1; -; mRNA. DR EMBL; X02457; CAA26297.1; -; mRNA. DR EMBL; M11887; AAA52656.1; -; mRNA. DR EMBL; M19670; AAA03683.2; -; Genomic_DNA. DR EMBL; AH003586; AAB02120.1; -; Genomic_DNA. DR EMBL; U03863; AAA03604.1; -; mRNA. DR EMBL; M86404; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; X57954; CAA41022.1; ALT_SEQ; mRNA. DR EMBL; U02935; AAA76608.2; -; Genomic_DNA. DR EMBL; AJ555412; CAD87771.1; -; Genomic_DNA. DR EMBL; U03862; AAA03603.1; -; mRNA. DR EMBL; M24042; AAA59653.1; -; mRNA. DR EMBL; Z23071; CAA80612.1; -; mRNA. DR EMBL; M84377; AAA59603.1; -; mRNA. DR EMBL; X60764; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; M84378; AAA59604.1; -; mRNA. DR EMBL; Z27120; CAA81644.1; -; mRNA. DR EMBL; Z46633; CAA86602.1; -; mRNA. DR EMBL; U18930; AAA87076.1; -; mRNA. DR EMBL; D83515; BAA11935.1; -; mRNA. DR EMBL; X96724; CAA65501.1; -; mRNA. DR EMBL; U56825; AAB17465.1; -; mRNA. DR EMBL; AH007560; AAD23437.1; -; Genomic_DNA. DR EMBL; AH007704; AAD30272.1; -; Genomic_DNA. DR EMBL; AH008013; AAD45690.1; -; Genomic_DNA. DR EMBL; AH008012; AAD45689.1; -; Genomic_DNA. DR EMBL; AH008007; AAD45324.1; -; Genomic_DNA. DR PIR; B24512; HLHU10. DR PIR; I37470; I37470. DR PIR; I37542; I37542. DR PIR; I38418; I38418. DR PIR; I38442; I38442. DR PIR; I38443; I38443. DR PIR; I55948; HLHUA2. DR PIR; I61857; I61857. DR PIR; I61902; I61902. DR PIR; I84448; I84448. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR PDB; 1AKJ; X-ray; 2.65 A; A=25-300. DR PDB; 1AO7; X-ray; 2.60 A; A=25-299. DR PDB; 1AQD; X-ray; 2.45 A; C/F/I/L=127-141. DR PDB; 1B0G; X-ray; 2.50 A; A/D=25-299. DR PDB; 1B0R; X-ray; 2.90 A; A=25-299. DR PDB; 1BD2; X-ray; 2.50 A; A=25-299. DR PDB; 1DUY; X-ray; 2.15 A; A/D=25-299. DR PDB; 1DUZ; X-ray; 1.80 A; A/D=25-299. DR PDB; 1EEY; X-ray; 2.25 A; A/D=25-299. DR PDB; 1EEZ; X-ray; 2.30 A; A/D=25-299. DR PDB; 1HHG; X-ray; 2.60 A; A/D=25-299. DR PDB; 1HHH; X-ray; 3.00 A; A=25-299. DR PDB; 1HHI; X-ray; 2.50 A; A/D=25-299. DR PDB; 1HHJ; X-ray; 2.50 A; A/D=25-299. DR PDB; 1HHK; X-ray; 2.50 A; A/D=25-299. DR PDB; 1HLA; X-ray; 3.50 A; A=25-294. DR PDB; 1I1F; X-ray; 2.80 A; A/D=25-299. DR PDB; 1I1Y; X-ray; 2.20 A; A/D=25-299. DR PDB; 1I4F; X-ray; 1.40 A; A=25-299. DR PDB; 1I7R; X-ray; 2.20 A; A/D=25-299. DR PDB; 1I7T; X-ray; 2.80 A; A/D=25-299. DR PDB; 1I7U; X-ray; 1.80 A; A/D=25-299. DR PDB; 1IM3; X-ray; 2.20 A; A/E/I/M=25-299. DR PDB; 1JF1; X-ray; 1.85 A; A=25-299. DR PDB; 1JHT; X-ray; 2.15 A; A=25-299. DR PDB; 1LP9; X-ray; 2.00 A; A/H=25-299. DR PDB; 1OGA; X-ray; 1.40 A; A=25-300. DR PDB; 1P7Q; X-ray; 3.40 A; A=25-300. DR PDB; 1QEW; X-ray; 2.20 A; A=25-299. DR PDB; 1QR1; X-ray; 2.40 A; A/D=25-299. DR PDB; 1QRN; X-ray; 2.80 A; A=25-298. DR PDB; 1QSE; X-ray; 2.80 A; A=25-298. DR PDB; 1QSF; X-ray; 2.80 A; A=25-298. DR PDB; 1S8D; X-ray; 2.20 A; A=25-299. DR PDB; 1S9W; X-ray; 2.20 A; A=25-298. DR PDB; 1S9X; X-ray; 2.50 A; A=25-298. DR PDB; 1S9Y; X-ray; 2.30 A; A=25-298. DR PDB; 1T1W; X-ray; 2.20 A; A=25-299. DR PDB; 1T1X; X-ray; 2.20 A; A=25-299. DR PDB; 1T1Y; X-ray; 2.00 A; A=25-299. DR PDB; 1T1Z; X-ray; 1.90 A; A=25-299. DR PDB; 1T20; X-ray; 2.20 A; A=25-299. DR PDB; 1T21; X-ray; 2.19 A; A=25-299. DR PDB; 1T22; X-ray; 2.20 A; A=25-299. DR PDB; 1TVB; X-ray; 1.80 A; A/D=25-299. DR PDB; 1TVH; X-ray; 1.80 A; A/D=25-299. DR PDB; 1UR7; Model; -; A=25-299. DR PDB; 2AV1; X-ray; 1.95 A; A/D=25-299. DR PDB; 2AV7; X-ray; 2.05 A; A/D=25-299. DR PDB; 2BNQ; X-ray; 1.70 A; A=25-300. DR PDB; 2BNR; X-ray; 1.90 A; A=25-300. DR PDB; 2C7U; X-ray; 2.38 A; A/D=25-300. DR PDB; 2CLR; X-ray; 2.00 A; A/D=25-299. DR PDB; 2F53; X-ray; 2.10 A; A=25-299. DR PDB; 2F54; X-ray; 2.70 A; A/F=25-298. DR PDB; 2GIT; X-ray; 1.70 A; A/D=25-299. DR PDB; 2GJ6; X-ray; 2.56 A; A=25-299. DR PDB; 2GT9; X-ray; 1.75 A; A/D=25-299. DR PDB; 2GTW; X-ray; 1.55 A; A/D=25-299. DR PDB; 2GTZ; X-ray; 1.70 A; A/D=25-299. DR PDB; 2GUO; X-ray; 1.90 A; A/D=25-299. DR PDB; 2J8U; X-ray; 2.88 A; A/H=25-299. DR PDB; 2JCC; X-ray; 2.50 A; A/H=25-299. DR PDB; 2P5E; X-ray; 1.89 A; A=25-300. DR PDB; 2P5W; X-ray; 2.20 A; A=25-300. DR PDB; 2PYE; X-ray; 2.30 A; A=25-300. DR PDB; 2UWE; X-ray; 2.40 A; A/H=25-299. DR PDB; 2V2W; X-ray; 1.60 A; A/D=25-300. DR PDB; 2V2X; X-ray; 1.60 A; A/D=25-300. DR PDB; 2VLJ; X-ray; 2.40 A; A=25-300. DR PDB; 2VLK; X-ray; 2.50 A; A=25-300. DR PDB; 2VLL; X-ray; 1.60 A; A/D=25-300. DR PDB; 2VLR; X-ray; 2.30 A; A/F=25-300. DR PDB; 2X4N; X-ray; 2.34 A; A/D=25-299. DR PDB; 2X4O; X-ray; 2.30 A; A/D=25-299. DR PDB; 2X4P; X-ray; 2.30 A; A/D=25-299. DR PDB; 2X4Q; X-ray; 1.90 A; A/D=25-299. DR PDB; 2X4R; X-ray; 2.30 A; A/D=25-299. DR PDB; 2X4S; X-ray; 2.55 A; A/D=25-299. DR PDB; 2X4T; X-ray; 2.30 A; A/D=25-299. DR PDB; 2X4U; X-ray; 2.10 A; A/D=25-299. DR PDB; 2X70; X-ray; 2.00 A; A/D=25-299. DR PDB; 3BGM; X-ray; 1.60 A; A=25-298. DR PDB; 3BH8; X-ray; 1.65 A; A=25-298. DR PDB; 3BH9; X-ray; 1.70 A; A=25-299. DR PDB; 3BHB; X-ray; 2.20 A; A=25-298. DR PDB; 3D25; X-ray; 1.30 A; A=25-298. DR PDB; 3D39; X-ray; 2.81 A; A=25-299. DR PDB; 3D3V; X-ray; 2.80 A; A=25-299. DR PDB; 3FQN; X-ray; 1.65 A; A=25-299. DR PDB; 3FQR; X-ray; 1.70 A; A=25-299. DR PDB; 3FQT; X-ray; 1.80 A; A=25-299. DR PDB; 3FQU; X-ray; 1.80 A; A=25-299. DR PDB; 3FQW; X-ray; 1.93 A; A=25-299. DR PDB; 3FQX; X-ray; 1.70 A; A=25-299. DR PDB; 3FT2; X-ray; 1.80 A; A=25-299. DR PDB; 3FT3; X-ray; 1.95 A; A=25-299. DR PDB; 3FT4; X-ray; 1.90 A; A=25-299. DR PDB; 3GIV; X-ray; 2.00 A; A/D=25-299. DR PDB; 3GJF; X-ray; 1.90 A; A/D=25-300. DR PDB; 3GSN; X-ray; 2.80 A; H=25-298. DR PDB; 3GSO; X-ray; 1.60 A; A=25-298. DR PDB; 3GSQ; X-ray; 2.12 A; A=25-298. DR PDB; 3GSR; X-ray; 1.95 A; A=25-298. DR PDB; 3GSU; X-ray; 1.80 A; A=25-299. DR PDB; 3GSV; X-ray; 1.90 A; A=25-299. DR PDB; 3GSW; X-ray; 1.81 A; A=25-298. DR PDB; 3GSX; X-ray; 2.10 A; A=25-298. DR PDB; 3H7B; X-ray; 1.88 A; A/D=25-299. DR PDB; 3H9H; X-ray; 2.00 A; A/D=25-299. DR PDB; 3H9S; X-ray; 2.70 A; A=25-299. DR PDB; 3HAE; X-ray; 2.90 A; A/D/J/P=25-300. DR PDB; 3HLA; X-ray; 2.60 A; A=25-294. DR PDB; 3HPJ; X-ray; 2.00 A; A/D=25-299. DR PDB; 3I6G; X-ray; 2.20 A; A/D=25-299. DR PDB; 3I6K; X-ray; 2.80 A; A/E=25-299. DR PDB; 3IXA; X-ray; 2.10 A; A/D=25-299. DR PDB; 3KLA; X-ray; 1.65 A; A/D=25-299. DR PDB; 3MGO; X-ray; 2.30 A; A/D/G/J=25-299. DR PDB; 3MGT; X-ray; 2.20 A; A/D/G/J=25-299. DR PDB; 3MR9; X-ray; 1.93 A; A=25-300. DR PDB; 3MRB; X-ray; 1.40 A; A=25-300. DR PDB; 3MRC; X-ray; 1.80 A; A=25-300. DR PDB; 3MRD; X-ray; 1.70 A; A=25-300. DR PDB; 3MRE; X-ray; 1.10 A; A=25-300. DR PDB; 3MRF; X-ray; 2.30 A; A=25-300. DR PDB; 3MRG; X-ray; 1.30 A; A=25-300. DR PDB; 3MRH; X-ray; 2.40 A; A=25-300. DR PDB; 3MRI; X-ray; 2.10 A; A=25-300. DR PDB; 3MRJ; X-ray; 1.87 A; A=25-300. DR PDB; 3MRK; X-ray; 1.40 A; A=25-300. DR PDB; 3MRL; X-ray; 2.41 A; A=25-300. DR PDB; 3MRM; X-ray; 1.90 A; A=25-300. DR PDB; 3MRN; X-ray; 2.30 A; A=25-300. DR PDB; 3MRO; X-ray; 2.35 A; A=25-300. DR PDB; 3MRP; X-ray; 2.10 A; A=25-300. DR PDB; 3MRQ; X-ray; 2.20 A; A=25-300. DR PDB; 3MRR; X-ray; 1.60 A; A=25-300. DR PDB; 3MYJ; X-ray; 1.89 A; A/D=25-299. DR PDB; 3O3A; X-ray; 1.80 A; A/D=25-299. DR PDB; 3O3B; X-ray; 1.90 A; A/D=25-299. DR PDB; 3O3D; X-ray; 1.70 A; A/D=25-299. DR PDB; 3O3E; X-ray; 1.85 A; A/D=25-299. DR PDB; 3O4L; X-ray; 2.54 A; A=25-300. DR PDB; 3PWJ; X-ray; 1.70 A; A/D=25-299. DR PDB; 3PWL; X-ray; 1.65 A; A/D=25-299. DR PDB; 3PWN; X-ray; 1.60 A; A/D=25-299. DR PDB; 3PWP; X-ray; 2.69 A; A=25-299. DR PDB; 3QDG; X-ray; 2.69 A; A=25-299. DR PDB; 3QDJ; X-ray; 2.30 A; A=25-299. DR PDB; 3QDM; X-ray; 2.80 A; A=25-299. DR PDB; 3QEQ; X-ray; 2.59 A; A=25-299. DR PDB; 3QFD; X-ray; 1.68 A; A/D=25-299. DR PDB; 3QFJ; X-ray; 2.29 A; A=25-299. DR PDB; 3REW; X-ray; 1.90 A; A/D=25-299. DR PDB; 3TO2; X-ray; 2.60 A; A=25-299. DR PDB; 3UTQ; X-ray; 1.67 A; A=25-300. DR PDB; 3UTS; X-ray; 2.71 A; A/F=25-300. DR PDB; 3UTT; X-ray; 2.60 A; A/F=25-299. DR PDB; 3V5D; X-ray; 2.00 A; A/D=25-299. DR PDB; 3V5H; X-ray; 1.63 A; A/D=25-299. DR PDB; 3V5K; X-ray; 2.31 A; A/D=25-299. DR PDB; 4E5X; X-ray; 1.95 A; A/D=25-299. DR PDB; 4EMZ; X-ray; 2.90 A; D/E=338-365. DR PDB; 4EN2; X-ray; 2.58 A; D/E=338-365. DR PDB; 4EUP; X-ray; 2.88 A; A/D=25-299. DR PDB; 4FTV; X-ray; 2.74 A; A=25-299. DR PDB; 4GKN; X-ray; 2.75 A; A/D=25-300. DR PDB; 4GKS; X-ray; 2.35 A; A/D=25-300. DR PDB; 4I4W; X-ray; 1.77 A; A=25-300. DR PDB; 4JFD; X-ray; 2.46 A; A=25-300. DR PDB; 4JFE; X-ray; 2.70 A; A=25-300. DR PDB; 4JFF; X-ray; 2.43 A; A=25-300. DR PDB; 4JFO; X-ray; 2.11 A; A/D=25-299. DR PDB; 4JFP; X-ray; 1.91 A; A/D=25-300. DR PDB; 4JFQ; X-ray; 1.90 A; A/D=25-300. DR PDB; 4K7F; X-ray; 2.00 A; A/D=25-299. DR PDB; 4L29; X-ray; 3.09 A; A/C/E/G/I/K/M/O/Q/S/U/W/Y/a=25-300. DR PDB; 4L3C; X-ray; 2.64 A; A/C/E/G/I/K/M/O/Q/S/U/W/Y/a=25-300. DR PDB; 4L3E; X-ray; 2.56 A; A=25-299. DR PDB; 4MNQ; X-ray; 2.74 A; A=25-300. DR PDB; 4NNX; X-ray; 2.10 A; A=25-298. DR PDB; 4NNY; X-ray; 1.90 A; A=25-298. DR PDB; 4NO0; X-ray; 2.70 A; A=25-300. DR PDB; 4NO2; X-ray; 2.00 A; A=25-298. DR PDB; 4NO3; X-ray; 1.70 A; A=25-298. DR PDB; 4NO5; X-ray; 2.10 A; A=25-299. DR PDB; 4OV5; X-ray; 2.20 A; C/F/I/L/O/R=128-141. DR PDB; 4QOK; X-ray; 3.00 A; A=25-300. DR PDB; 4U6X; X-ray; 1.68 A; A=25-300. DR PDB; 4U6Y; X-ray; 1.47 A; A=25-300. DR PDB; 4UQ3; X-ray; 2.10 A; A/C=25-299. DR PDB; 4WJ5; X-ray; 1.65 A; A/D=25-299. DR PDB; 4WUU; X-ray; 3.05 A; A=25-300. DR PDB; 5C07; X-ray; 2.11 A; A/F=25-300. DR PDB; 5C08; X-ray; 2.33 A; A/F=25-300. DR PDB; 5C09; X-ray; 2.48 A; A/F=25-300. DR PDB; 5C0A; X-ray; 2.46 A; A/F=25-300. DR PDB; 5C0B; X-ray; 2.03 A; A/F=25-299. DR PDB; 5C0C; X-ray; 1.97 A; A/F=25-300. DR PDB; 5C0D; X-ray; 1.68 A; A=25-300. DR PDB; 5C0E; X-ray; 1.49 A; A=25-300. DR PDB; 5C0F; X-ray; 1.46 A; A=25-300. DR PDB; 5C0G; X-ray; 1.37 A; A=25-300. DR PDB; 5C0I; X-ray; 1.53 A; A=25-300. DR PDB; 5C0J; X-ray; 1.64 A; A=25-300. DR PDB; 5D2L; X-ray; 3.51 A; A/C/G/M=25-299. DR PDB; 5D2N; X-ray; 2.10 A; A/H=25-299. DR PDB; 5D9S; X-ray; 1.87 A; A=25-298. DR PDB; 5DDH; X-ray; 1.50 A; A=25-298. DR PDB; 5E00; X-ray; 1.70 A; A=25-299. DR PDB; 5E6I; X-ray; 4.00 A; C/I/M/R=25-299. DR PDB; 5E9D; X-ray; 2.51 A; A/F=25-299. DR PDB; 5ENW; X-ray; 1.85 A; A=25-298. DR PDB; 5EOT; X-ray; 2.10 A; A=26-298. DR PDB; 5EU3; X-ray; 1.97 A; A=25-300. DR PDB; 5EU4; X-ray; 2.12 A; A/D=25-300. DR PDB; 5EU5; X-ray; 1.54 A; A=25-300. DR PDB; 5EU6; X-ray; 2.02 A; A=25-300. DR PDB; 5EUO; X-ray; 2.10 A; A/C=25-299. DR PDB; 5F7D; X-ray; 2.30 A; A=26-298. DR PDB; 5F9J; X-ray; 2.51 A; A=25-298. DR PDB; 5FA3; X-ray; 1.86 A; A=26-298. DR PDB; 5FA4; X-ray; 2.40 A; A=25-298. DR PDB; 5FDW; X-ray; 2.70 A; A=25-298. DR PDB; 5HHM; X-ray; 2.50 A; A/F=25-300. DR PDB; 5HHN; X-ray; 2.03 A; A=25-298. DR PDB; 5HHO; X-ray; 2.95 A; A=25-300. DR PDB; 5HHP; X-ray; 1.90 A; A=25-298. DR PDB; 5HHQ; X-ray; 2.10 A; A=25-298. DR PDB; 5HYJ; X-ray; 3.06 A; A/F=25-300. DR PDB; 5IRO; X-ray; 2.64 A; A/E/I/M/Q/U=25-299. DR PDB; 5ISZ; X-ray; 2.06 A; A=25-299. DR PDB; 5JHD; X-ray; 2.46 A; A/F=25-299. DR PDB; 5JZI; X-ray; 2.50 A; A/F=25-299. DR PDB; 5MEN; X-ray; 2.81 A; A=25-300. DR PDB; 5MEO; X-ray; 1.77 A; A=25-300. DR PDB; 5MEP; X-ray; 2.71 A; A/D=25-300. DR PDB; 5MEQ; X-ray; 2.27 A; A=25-300. DR PDB; 5MER; X-ray; 1.88 A; A/D=25-300. DR PDB; 5N1Y; X-ray; 1.39 A; A=25-300. DR PDB; 5N6B; X-ray; 1.71 A; A/D=25-300. DR PDB; 5NHT; X-ray; 3.20 A; H=25-300. DR PDB; 5NME; X-ray; 2.94 A; A/F=25-300. DR PDB; 5NMF; X-ray; 2.89 A; A/F=25-300. DR PDB; 5NMG; X-ray; 2.75 A; A/F=25-300. DR PDB; 5NMH; X-ray; 1.55 A; A=25-300. DR PDB; 5NMK; X-ray; 1.66 A; A=25-300. DR PDB; 5NQK; X-ray; 3.25 A; H=25-300. DR PDB; 5SWQ; X-ray; 2.00 A; A=25-300. DR PDB; 5TEZ; X-ray; 1.70 A; A=25-299. DR PDB; 5W1W; X-ray; 3.10 A; C/H/M/R=3-11. DR PDB; 5WSH; X-ray; 2.00 A; A=25-299. DR PDBsum; 1AKJ; -. DR PDBsum; 1AO7; -. DR PDBsum; 1AQD; -. DR PDBsum; 1B0G; -. DR PDBsum; 1B0R; -. DR PDBsum; 1BD2; -. DR PDBsum; 1DUY; -. DR PDBsum; 1DUZ; -. DR PDBsum; 1EEY; -. DR PDBsum; 1EEZ; -. DR PDBsum; 1HHG; -. DR PDBsum; 1HHH; -. DR PDBsum; 1HHI; -. DR PDBsum; 1HHJ; -. DR PDBsum; 1HHK; -. DR PDBsum; 1HLA; -. DR PDBsum; 1I1F; -. DR PDBsum; 1I1Y; -. DR PDBsum; 1I4F; -. DR PDBsum; 1I7R; -. DR PDBsum; 1I7T; -. DR PDBsum; 1I7U; -. DR PDBsum; 1IM3; -. DR PDBsum; 1JF1; -. DR PDBsum; 1JHT; -. DR PDBsum; 1LP9; -. DR PDBsum; 1OGA; -. DR PDBsum; 1P7Q; -. DR PDBsum; 1QEW; -. DR PDBsum; 1QR1; -. DR PDBsum; 1QRN; -. DR PDBsum; 1QSE; -. DR PDBsum; 1QSF; -. DR PDBsum; 1S8D; -. DR PDBsum; 1S9W; -. DR PDBsum; 1S9X; -. DR PDBsum; 1S9Y; -. DR PDBsum; 1T1W; -. DR PDBsum; 1T1X; -. DR PDBsum; 1T1Y; -. DR PDBsum; 1T1Z; -. DR PDBsum; 1T20; -. DR PDBsum; 1T21; -. DR PDBsum; 1T22; -. DR PDBsum; 1TVB; -. DR PDBsum; 1TVH; -. DR PDBsum; 1UR7; -. DR PDBsum; 2AV1; -. DR PDBsum; 2AV7; -. DR PDBsum; 2BNQ; -. DR PDBsum; 2BNR; -. DR PDBsum; 2C7U; -. DR PDBsum; 2CLR; -. DR PDBsum; 2F53; -. DR PDBsum; 2F54; -. DR PDBsum; 2GIT; -. DR PDBsum; 2GJ6; -. DR PDBsum; 2GT9; -. DR PDBsum; 2GTW; -. DR PDBsum; 2GTZ; -. DR PDBsum; 2GUO; -. DR PDBsum; 2J8U; -. DR PDBsum; 2JCC; -. DR PDBsum; 2P5E; -. DR PDBsum; 2P5W; -. DR PDBsum; 2PYE; -. DR PDBsum; 2UWE; -. DR PDBsum; 2V2W; -. DR PDBsum; 2V2X; -. DR PDBsum; 2VLJ; -. DR PDBsum; 2VLK; -. DR PDBsum; 2VLL; -. DR PDBsum; 2VLR; -. DR PDBsum; 2X4N; -. DR PDBsum; 2X4O; -. DR PDBsum; 2X4P; -. DR PDBsum; 2X4Q; -. DR PDBsum; 2X4R; -. DR PDBsum; 2X4S; -. DR PDBsum; 2X4T; -. DR PDBsum; 2X4U; -. DR PDBsum; 2X70; -. DR PDBsum; 3BGM; -. DR PDBsum; 3BH8; -. DR PDBsum; 3BH9; -. DR PDBsum; 3BHB; -. DR PDBsum; 3D25; -. DR PDBsum; 3D39; -. DR PDBsum; 3D3V; -. DR PDBsum; 3FQN; -. DR PDBsum; 3FQR; -. DR PDBsum; 3FQT; -. DR PDBsum; 3FQU; -. DR PDBsum; 3FQW; -. DR PDBsum; 3FQX; -. DR PDBsum; 3FT2; -. DR PDBsum; 3FT3; -. DR PDBsum; 3FT4; -. DR PDBsum; 3GIV; -. DR PDBsum; 3GJF; -. DR PDBsum; 3GSN; -. DR PDBsum; 3GSO; -. DR PDBsum; 3GSQ; -. DR PDBsum; 3GSR; -. DR PDBsum; 3GSU; -. DR PDBsum; 3GSV; -. DR PDBsum; 3GSW; -. DR PDBsum; 3GSX; -. DR PDBsum; 3H7B; -. DR PDBsum; 3H9H; -. DR PDBsum; 3H9S; -. DR PDBsum; 3HAE; -. DR PDBsum; 3HLA; -. DR PDBsum; 3HPJ; -. DR PDBsum; 3I6G; -. DR PDBsum; 3I6K; -. DR PDBsum; 3IXA; -. DR PDBsum; 3KLA; -. DR PDBsum; 3MGO; -. DR PDBsum; 3MGT; -. DR PDBsum; 3MR9; -. DR PDBsum; 3MRB; -. DR PDBsum; 3MRC; -. DR PDBsum; 3MRD; -. DR PDBsum; 3MRE; -. DR PDBsum; 3MRF; -. DR PDBsum; 3MRG; -. DR PDBsum; 3MRH; -. DR PDBsum; 3MRI; -. DR PDBsum; 3MRJ; -. DR PDBsum; 3MRK; -. DR PDBsum; 3MRL; -. DR PDBsum; 3MRM; -. DR PDBsum; 3MRN; -. DR PDBsum; 3MRO; -. DR PDBsum; 3MRP; -. DR PDBsum; 3MRQ; -. DR PDBsum; 3MRR; -. DR PDBsum; 3MYJ; -. DR PDBsum; 3O3A; -. DR PDBsum; 3O3B; -. DR PDBsum; 3O3D; -. DR PDBsum; 3O3E; -. DR PDBsum; 3O4L; -. DR PDBsum; 3PWJ; -. DR PDBsum; 3PWL; -. DR PDBsum; 3PWN; -. DR PDBsum; 3PWP; -. DR PDBsum; 3QDG; -. DR PDBsum; 3QDJ; -. DR PDBsum; 3QDM; -. DR PDBsum; 3QEQ; -. DR PDBsum; 3QFD; -. DR PDBsum; 3QFJ; -. DR PDBsum; 3REW; -. DR PDBsum; 3TO2; -. DR PDBsum; 3UTQ; -. DR PDBsum; 3UTS; -. DR PDBsum; 3UTT; -. DR PDBsum; 3V5D; -. DR PDBsum; 3V5H; -. DR PDBsum; 3V5K; -. DR PDBsum; 4E5X; -. DR PDBsum; 4EMZ; -. DR PDBsum; 4EN2; -. DR PDBsum; 4EUP; -. DR PDBsum; 4FTV; -. DR PDBsum; 4GKN; -. DR PDBsum; 4GKS; -. DR PDBsum; 4I4W; -. DR PDBsum; 4JFD; -. DR PDBsum; 4JFE; -. DR PDBsum; 4JFF; -. DR PDBsum; 4JFO; -. DR PDBsum; 4JFP; -. DR PDBsum; 4JFQ; -. DR PDBsum; 4K7F; -. DR PDBsum; 4L29; -. DR PDBsum; 4L3C; -. DR PDBsum; 4L3E; -. DR PDBsum; 4MNQ; -. DR PDBsum; 4NNX; -. DR PDBsum; 4NNY; -. DR PDBsum; 4NO0; -. DR PDBsum; 4NO2; -. DR PDBsum; 4NO3; -. DR PDBsum; 4NO5; -. DR PDBsum; 4OV5; -. DR PDBsum; 4QOK; -. DR PDBsum; 4U6X; -. DR PDBsum; 4U6Y; -. DR PDBsum; 4UQ3; -. DR PDBsum; 4WJ5; -. DR PDBsum; 4WUU; -. DR PDBsum; 5C07; -. DR PDBsum; 5C08; -. DR PDBsum; 5C09; -. DR PDBsum; 5C0A; -. DR PDBsum; 5C0B; -. DR PDBsum; 5C0C; -. DR PDBsum; 5C0D; -. DR PDBsum; 5C0E; -. DR PDBsum; 5C0F; -. DR PDBsum; 5C0G; -. DR PDBsum; 5C0I; -. DR PDBsum; 5C0J; -. DR PDBsum; 5D2L; -. DR PDBsum; 5D2N; -. DR PDBsum; 5D9S; -. DR PDBsum; 5DDH; -. DR PDBsum; 5E00; -. DR PDBsum; 5E6I; -. DR PDBsum; 5E9D; -. DR PDBsum; 5ENW; -. DR PDBsum; 5EOT; -. DR PDBsum; 5EU3; -. DR PDBsum; 5EU4; -. DR PDBsum; 5EU5; -. DR PDBsum; 5EU6; -. DR PDBsum; 5EUO; -. DR PDBsum; 5F7D; -. DR PDBsum; 5F9J; -. DR PDBsum; 5FA3; -. DR PDBsum; 5FA4; -. DR PDBsum; 5FDW; -. DR PDBsum; 5HHM; -. DR PDBsum; 5HHN; -. DR PDBsum; 5HHO; -. DR PDBsum; 5HHP; -. DR PDBsum; 5HHQ; -. DR PDBsum; 5HYJ; -. DR PDBsum; 5IRO; -. DR PDBsum; 5ISZ; -. DR PDBsum; 5JHD; -. DR PDBsum; 5JZI; -. DR PDBsum; 5MEN; -. DR PDBsum; 5MEO; -. DR PDBsum; 5MEP; -. DR PDBsum; 5MEQ; -. DR PDBsum; 5MER; -. DR PDBsum; 5N1Y; -. DR PDBsum; 5N6B; -. DR PDBsum; 5NHT; -. DR PDBsum; 5NME; -. DR PDBsum; 5NMF; -. DR PDBsum; 5NMG; -. DR PDBsum; 5NMH; -. DR PDBsum; 5NMK; -. DR PDBsum; 5NQK; -. DR PDBsum; 5SWQ; -. DR PDBsum; 5TEZ; -. DR PDBsum; 5W1W; -. DR PDBsum; 5WSH; -. DR ProteinModelPortal; P01892; -. DR SMR; P01892; -. DR BioGrid; 109350; 90. DR IntAct; P01892; 31. DR MINT; P01892; -. DR DrugBank; DB02740; 3-Indolebutyric Acid. DR iPTMnet; P01892; -. DR PhosphoSitePlus; P01892; -. DR SwissPalm; P01892; -. DR DMDM; 122138; -. DR EPD; P01892; -. DR PeptideAtlas; P01892; -. DR PRIDE; P01892; -. DR Ensembl; ENST00000457879; ENSP00000403575; ENSG00000235657. DR Ensembl; ENST00000547271; ENSP00000447962; ENSG00000235657. DR Ensembl; ENST00000547522; ENSP00000448077; ENSG00000227715. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P01892; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-164940; Nef mediated downregulation of MHC class I complex cell surface expression. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-8866654; E3 ubiquitin ligases ubiquitinate target proteins. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR SIGNOR; P01892; -. DR ChiTaRS; HLA-A; human. DR EvolutionaryTrace; P01892; -. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; IDA:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB. DR GO; GO:0070971; C:endoplasmic reticulum exit site; IDA:UniProtKB. DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB. DR GO; GO:0005797; C:Golgi medial cisterna; IDA:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; IDA:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; IDA:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; IDA:UniProtKB. DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB. DR GO; GO:0005102; F:signaling receptor binding; IPI:BHF-UCL. DR GO; GO:0042608; F:T cell receptor binding; IDA:UniProtKB. DR GO; GO:0046977; F:TAP binding; IDA:UniProtKB. DR GO; GO:0019731; P:antibacterial humoral response; IDA:UniProtKB. DR GO; GO:0019885; P:antigen processing and presentation of endogenous peptide antigen via MHC class I; IDA:BHF-UCL. DR GO; GO:0002486; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:2001187; P:positive regulation of CD8-positive, alpha-beta T cell activation; IDA:BHF-UCL. DR GO; GO:2000566; P:positive regulation of CD8-positive, alpha-beta T cell proliferation; IDA:UniProtKB. DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IDA:UniProtKB. DR GO; GO:2000568; P:positive regulation of memory T cell activation; IDA:UniProtKB. DR GO; GO:0002726; P:positive regulation of T cell cytokine production; IDA:BHF-UCL. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0051290; P:protein heterotetramerization; IDA:CAFA. DR GO; GO:0016567; P:protein ubiquitination; TAS:Reactome. DR GO; GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Direct protein sequencing; KW Disulfide bond; Glycoprotein; Host-virus interaction; Immunity; KW Membrane; MHC I; Phosphoprotein; Polymorphism; Reference proteome; KW Signal; Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 {ECO:0000269|PubMed:92029}. FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-2 alpha chain. FT /FTId=PRO_0000018814. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:18088087, FT ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:19159218}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:12796775}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:12796775}. FT VARIANT 33 33 F -> Y (in allele A*02:05, allele FT A*02:06, allele A*02:08, allele A*02:10 FT and allele A*02:21; dbSNP:rs2075684). FT /FTId=VAR_004334. FT VARIANT 54 54 D -> N (in allele A*02:21; FT dbSNP:rs41549215). FT /FTId=VAR_004335. FT VARIANT 65 65 A -> G (in allele A*02:31; FT dbSNP:rs41557613). FT /FTId=VAR_016726. FT VARIANT 67 67 Q -> R (in allele A*02:02, allele A*02:05 FT and allele A*02:08; dbSNP:rs41559117). FT /FTId=VAR_004336. FT VARIANT 89 89 R -> G (polymorphism; dbSNP:rs199474430). FT {ECO:0000269|PubMed:26566883}. FT /FTId=VAR_076446. FT VARIANT 90 90 K -> N (in allele A*02:08 and allele FT A*02:20; dbSNP:rs199474436). FT /FTId=VAR_004337. FT VARIANT 94 94 H -> Q (in allele A*02:34 and allele FT A*02:35; dbSNP:rs78306866). FT /FTId=VAR_016727. FT VARIANT 97 97 T -> I (in allele A*02:11; FT dbSNP:rs199474457). FT /FTId=VAR_004338. FT VARIANT 98 98 H -> D (in allele A*02:11 and allele FT A*02:35; dbSNP:rs1136683). FT /FTId=VAR_016728. FT VARIANT 119 119 V -> L (in allele A*02:02, allele FT A*02:05, allele A*02:08 and allele FT A*02:17; dbSNP:rs1071743). FT /FTId=VAR_004339. FT VARIANT 121 121 R -> M (in allele A*02:04 and allele FT A*02:17; dbSNP:rs199474485). FT /FTId=VAR_004340. FT VARIANT 123 123 Y -> C (in allele A*02:07 and allele FT A*02:18; dbSNP:rs1136697). FT /FTId=VAR_004341. FT VARIANT 123 123 Y -> F (in allele A*02:10 and allele FT A*02:17; dbSNP:rs1136697). FT /FTId=VAR_004342. FT VARIANT 131 131 W -> G (in allele A*02:10; FT dbSNP:rs1136702). FT /FTId=VAR_004343. FT VARIANT 162 162 M -> K (in allele A*02:18; FT dbSNP:rs41549316). FT /FTId=VAR_004344. FT VARIANT 173 173 A -> T (in allele A*02:03; FT dbSNP:rs1059526). FT /FTId=VAR_004345. FT VARIANT 176 176 V -> E (in allele A*02:03 and allele FT A*02:13; dbSNP:rs9256983). FT {ECO:0000244|PubMed:21269460, FT ECO:0000244|PubMed:25944712}. FT /FTId=VAR_004346. FT VARIANT 180 180 L -> Q (in allele A*02:12, allele A*02:13 FT and allele A*02:37). FT /FTId=VAR_004348. FT VARIANT 180 180 L -> W (in allele A*02:02, allele FT A*02:03, allele A*02:05 and allele FT A*02:08; dbSNP:rs9260156). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_004347. FT VARIANT 187 187 T -> E (in allele A*02:16; requires 2 FT nucleotide substitutions). FT /FTId=VAR_004349. FT VARIANT 190 190 E -> D (in allele A*02:36 and allele FT A*02:37; dbSNP:rs879577815). FT /FTId=VAR_016729. FT VARIANT 191 191 W -> G (in allele A*02:36 and allele FT A*02:37; dbSNP:rs3098019). FT /FTId=VAR_016730. FT VARIANT 260 260 A -> E (in allele A*02:09; FT dbSNP:rs41540417). FT /FTId=VAR_004350. FT CONFLICT 115 115 G -> V (in Ref. 4; AAA52656). FT {ECO:0000305}. FT CONFLICT 140 140 Y -> V (in Ref. 4; AAA52656). FT {ECO:0000305}. FT CONFLICT 277 277 Q -> E (in Ref. 4; AAA52656). FT {ECO:0000305}. FT CONFLICT 318 318 F -> L (in Ref. 4; AAA52656). FT {ECO:0000305}. FT STRAND 27 36 {ECO:0000244|PDB:3D25}. FT STRAND 41 43 {ECO:0000244|PDB:5C0G}. FT STRAND 45 52 {ECO:0000244|PDB:3D25}. FT STRAND 55 61 {ECO:0000244|PDB:3D25}. FT STRAND 64 66 {ECO:0000244|PDB:3D25}. FT STRAND 70 73 {ECO:0000244|PDB:4E5X}. FT HELIX 74 78 {ECO:0000244|PDB:3D25}. FT HELIX 81 108 {ECO:0000244|PDB:3D25}. FT STRAND 113 115 {ECO:0000244|PDB:3D25}. FT STRAND 118 127 {ECO:0000244|PDB:3D25}. FT STRAND 129 131 {ECO:0000244|PDB:1B0R}. FT STRAND 133 142 {ECO:0000244|PDB:3D25}. FT STRAND 145 150 {ECO:0000244|PDB:3D25}. FT STRAND 152 155 {ECO:0000244|PDB:5IRO}. FT STRAND 157 159 {ECO:0000244|PDB:3D25}. FT HELIX 162 173 {ECO:0000244|PDB:3D25}. FT HELIX 176 185 {ECO:0000244|PDB:3D25}. FT HELIX 187 198 {ECO:0000244|PDB:3D25}. FT HELIX 200 203 {ECO:0000244|PDB:3D25}. FT STRAND 210 235 {ECO:0000244|PDB:3D25}. FT STRAND 238 243 {ECO:0000244|PDB:3D25}. FT STRAND 246 248 {ECO:0000244|PDB:3D25}. FT HELIX 249 251 {ECO:0000244|PDB:2GTW}. FT STRAND 252 254 {ECO:0000244|PDB:3D25}. FT STRAND 261 263 {ECO:0000244|PDB:3D25}. FT STRAND 265 274 {ECO:0000244|PDB:3D25}. FT STRAND 275 277 {ECO:0000244|PDB:4JFD}. FT HELIX 278 280 {ECO:0000244|PDB:3D25}. FT STRAND 281 286 {ECO:0000244|PDB:3D25}. FT STRAND 290 292 {ECO:0000244|PDB:2V2X}. FT STRAND 294 296 {ECO:0000244|PDB:3D25}. FT STRAND 348 350 {ECO:0000244|PDB:4EN2}. SQ SEQUENCE 365 AA; 40922 MW; B54A97B24B337C08 CRC64; MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDGETRK VKAHSQTHRV DLGTLRGYYN QSEAGSHTVQ RMYGCDVGSD WRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQTTKHK WEAAHVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDVSL TACKV // ID 1A02_PANTR Reviewed; 362 AA. AC P16210; DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1990, sequence version 1. DT 12-SEP-2018, entry version 125. DE RecName: Full=Patr class I histocompatibility antigen, A-5 alpha chain; DE AltName: Full=ChLa class I histocompatibility antigen, A-5 alpha chain; DE Flags: Precursor; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1690682; DOI=10.1111/j.1600-065X.1990.tb00040.x; RA Lawlor D.A., Warren E., Ward F.E., Parham P.; RT "Comparison of class I MHC alleles in humans and apes."; RL Immunol. Rev. 113:147-185(1990). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M30679; AAA87971.1; -; mRNA. DR PIR; I36962; I36962. DR UniGene; Ptr.1473; -. DR ProteinModelPortal; P16210; -. DR SMR; P16210; -. DR STRING; 9598.ENSPTRP00000061016; -. DR PaxDb; P16210; -. DR PRIDE; P16210; -. DR Ensembl; ENSPTRT00000072427; ENSPTRP00000061016; ENSPTRG00000041261. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR InParanoid; P16210; -. DR OMA; TESWIAP; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002277; Chromosome 6. DR Bgee; ENSPTRG00000038986; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 362 Patr class I histocompatibility antigen, FT A-5 alpha chain. FT /FTId=PRO_0000018911. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 362 AA; 40487 MW; 9B5A674445037056 CRC64; MQVTAPRTVL LLLSAALALT ETWAGSHSMK YFYTAVSRPG RGEPRFISVG YVDDTQFVWF DSDAASPREE PRAPWIEQEG PEYWDRETQI SKTNAQTYRE SLRNLRGYYN QSEAGSHIIQ RMYGCDMGPD GRLLRGYEQY AYDGKDYIAL NQDLSSWTAA DTAAQITQRK WEAARWAEQL RAYLEGTCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1A03_GORGO Reviewed; 365 AA. AC P30377; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 28-FEB-2018, entry version 95. DE RecName: Full=Class I histocompatibility antigen, Gogo-A*0401 alpha chain; DE Flags: Precursor; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1744581; DOI=10.1084/jem.174.6.1491; RA Lawlor D.A., Warren E., Taylor P., Parham P.; RT "Gorilla class I major histocompatibility complex alleles: comparison RT to human and chimpanzee class I."; RL J. Exp. Med. 174:1491-1509(1991). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X60257; CAA42809.1; -; mRNA. DR PIR; JH0536; JH0536. DR ProteinModelPortal; P30377; -. DR SMR; P30377; -. DR PRIDE; P30377; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000001519; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 365 Class I histocompatibility antigen, Gogo- FT A*0401 alpha chain. FT /FTId=PRO_0000018899. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000250|UniProtKB:P04439}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000250|UniProtKB:P04439}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000250|UniProtKB:P04439}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 365 AA; 40934 MW; 9207ABBDF9B406C9 CRC64; MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEE PEYWDGETRN MKARSQTDRV DLGTLRGYYN QSEDGSHTIQ RMYGCDVGSD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAAHEAEQL RAYLEGTCVE WLRRYLENGK ETLQLTDAPK THMTHHPVSD HEAILRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDVSL TACKV // ID 1A03_HUMAN Reviewed; 365 AA. AC P04439; O19546; O19756; Q65A82; Q9GJE6; Q9GJE7; Q9GJE8; Q9MYE6; AC Q9MYG4; Q9TPR8; DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot. DT 22-AUG-2003, sequence version 2. DT 12-SEP-2018, entry version 180. DE RecName: Full=HLA class I histocompatibility antigen, A-3 alpha chain; DE AltName: Full=MHC class I antigen A*3; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE A*03:01). RX PubMed=6609814; RA Strachan T., Sodoyer R., Damotte M., Jordan B.R.; RT "Complete nucleotide sequence of a functional class I HLA gene, HLA- RT A3: implications for the evolution of HLA genes."; RL EMBO J. 3:887-894(1984). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE A*03:01). RA Ellexson M.E., Hildebrand W.H.; RL Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE A*03:01). RA Shiina S., Tamiya G., Oka A., Inoko H.; RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE (ALLELE A*03:02). RX PubMed=2993417; RA Cowan E.P., Jordan B.E., Coligan J.E.; RT "Molecular cloning and DNA sequence analysis of genes encoding RT cytotoxic T lymphocyte-defined HLA-A3 subtypes: the E1 subtype."; RL J. Immunol. 135:2835-2841(1985). RN [5] RP NUCLEOTIDE SEQUENCE (ALLELE A*03:02). RA Bettinotti M.P., Hadzikadic L., Adams S., Marincola F.M.; RT "Complete coding sequence of HLA-A*0302."; RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Mayor N.P.; RT "Full length sequence of an HLA-A*0301 intron 2 variant."; RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-341 (ALLELE A*03:04). RX PubMed=10079303; DOI=10.1007/s002510050506; RA Santos S., Balas A., Garcia-Sanchez F., Lillo R., Merino J.L., RA Vicario J.L.; RT "Complete cDNA coding sequence of a new HLA-A3 subtype (A*0304) with a RT new HLA polymorphism at exon 3."; RL Immunogenetics 49:360-361(1999). RN [9] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*03:05). RA Becher M.P., Wu J., Williams T.; RT "Novel human HLA-A alleles identified in potential bone marrow RT donors."; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE OF 26-298 (ALLELE A*03:05). RC TISSUE=Blood; RA Poli F., Frison S., Crespiatico L., Longhi E.; RT "Identification of a HLA-A*03 new variant."; RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases. RN [11] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE A*03:06). RX PubMed=12135434; DOI=10.1034/j.1399-0039.2002.590413.x; RA Bradshaw D., Gans C.P., Jones P., Rizzuto G., Steiner N., Mitton W., RA Ng J., Koester R., Hartzman R.J., Hurley C.K.; RT "Novel HLA-A locus alleles including A*01012, A*0306, A*0308, A*2616, RT A*2617, A*3009, A*3206, A*3403, A*3602 and A*6604."; RL Tissue Antigens 59:325-327(2002). RN [12] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352; SER-356 AND RP SER-359, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [13] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [14] RP X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 25-298 (ALLELE A*03:01) IN RP COMPLEX WITH PLP1 ANTIGENIC PEPTIDE, AND DISULFIDE BONDS. RX PubMed=21543847; DOI=10.1107/S0907444911007888; RA McMahon R.M., Friis L., Siebold C., Friese M.A., Fugger L., RA Jones E.Y.; RT "Structure of HLA-A*0301 in complex with a peptide of proteolipid RT protein: insights into the role of HLA-A alleles in susceptibility to RT multiple sclerosis."; RL Acta Crystallogr. D 67:447-454(2011). RN [15] RP VARIANT [LARGE SCALE ANALYSIS] THR-166, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of A-3 are known: A*03:01 (A- CC 3.1), A*03:02, A*03:04, A*03:05 and A*03:06. The sequence shown is CC that of A*03:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X00492; CAA25162.1; ALT_SEQ; Genomic_DNA. DR EMBL; U32184; AAB63980.1; -; mRNA. DR EMBL; BA000025; BAB63400.1; -; Genomic_DNA. DR EMBL; AF217561; AAF28734.1; -; mRNA. DR EMBL; AF015930; AAB66582.1; -; mRNA. DR EMBL; AH008295; AAF03243.1; -; Genomic_DNA. DR EMBL; AJ401085; CAC06086.1; -; Genomic_DNA. DR EMBL; AJ401086; CAC06087.1; -; Genomic_DNA. DR EMBL; AJ401087; CAC06088.1; -; Genomic_DNA. DR EMBL; AJ748743; CAG38621.1; -; Genomic_DNA. DR EMBL; AL671277; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AH009116; AAF29557.1; -; Genomic_DNA. DR CCDS; CCDS34373.1; -. DR PIR; A02192; HLHUA3. DR RefSeq; NP_002107.3; NM_002116.7. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR PDB; 2XPG; X-ray; 2.60 A; A=25-298. DR PDB; 3RL1; X-ray; 2.00 A; A=25-298. DR PDB; 3RL2; X-ray; 2.39 A; A=25-298. DR PDB; 6ENY; EM; 5.80 A; F=25-365. DR PDBsum; 2XPG; -. DR PDBsum; 3RL1; -. DR PDBsum; 3RL2; -. DR PDBsum; 6ENY; -. DR ProteinModelPortal; P04439; -. DR SMR; P04439; -. DR BioGrid; 109350; 90. DR IntAct; P04439; 14. DR STRING; 9606.ENSP00000366005; -. DR BindingDB; P04439; -. DR ChEMBL; CHEMBL2632; -. DR iPTMnet; P04439; -. DR SwissPalm; P04439; -. DR BioMuta; PIKFYVE; -. DR DMDM; 34223717; -. DR EPD; P04439; -. DR MaxQB; P04439; -. DR PaxDb; P04439; -. DR PeptideAtlas; P04439; -. DR PRIDE; P04439; -. DR DNASU; 3105; -. DR Ensembl; ENST00000376809; ENSP00000366005; ENSG00000206503. DR Ensembl; ENST00000396634; ENSP00000379873; ENSG00000206503. DR GeneID; 3105; -. DR CTD; 3105; -. DR DisGeNET; 3105; -. DR EuPathDB; HostDB:ENSG00000206503.11; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR HPA; CAB078470; -. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P04439; -. DR OpenTargets; ENSG00000206503; -. DR PharmGKB; PA35055; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR PhylomeDB; P04439; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-8866654; E3 ubiquitin ligases ubiquitinate target proteins. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR GeneWiki; HLA-A; -. DR GenomeRNAi; 3105; -. DR PMAP-CutDB; P04439; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000206503; Expressed in 239 organ(s), highest expression level in mononuclear cell. DR CleanEx; HS_HLA-A; -. DR ExpressionAtlas; P04439; baseline and differential. DR Genevisible; P04439; HS. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB. DR GO; GO:0016020; C:membrane; HDA:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0046977; F:TAP binding; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0016567; P:protein ubiquitination; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Phosphoprotein; Polymorphism; KW Reference proteome; Signal; Transmembrane; Transmembrane helix; KW Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-3 alpha chain. FT /FTId=PRO_0000018815. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:21543847}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:21543847}. FT VARIANT 89 89 R -> G (in dbSNP:rs199474430). FT /FTId=VAR_050310. FT VARIANT 94 94 Q -> H (in dbSNP:rs78306866). FT /FTId=VAR_050311. FT VARIANT 101 101 D -> N (in dbSNP:rs1136688). FT /FTId=VAR_050312. FT VARIANT 121 121 I -> M (in dbSNP:rs1136695). FT /FTId=VAR_050313. FT VARIANT 129 129 S -> P (in dbSNP:rs1136700). FT /FTId=VAR_050314. FT VARIANT 131 131 G -> W (in dbSNP:rs1136702). FT /FTId=VAR_050315. FT VARIANT 133 133 F -> L (in dbSNP:rs1059488). FT /FTId=VAR_050316. FT VARIANT 151 151 N -> K (in dbSNP:rs1059509). FT /FTId=VAR_050317. FT VARIANT 166 166 I -> T (in dbSNP:rs1059516). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_050318. FT VARIANT 169 169 R -> H (in dbSNP:rs1059520). FT /FTId=VAR_050319. FT VARIANT 176 176 E -> V (in allele A*03:02; FT dbSNP:rs9256983). FT /FTId=VAR_004351. FT VARIANT 180 180 L -> Q (in allele A*03:02). FT /FTId=VAR_004352. FT VARIANT 185 185 D -> E (in allele A*03:05; FT dbSNP:rs1059542). FT /FTId=VAR_016604. FT VARIANT 186 186 G -> A (in allele A*03:06; FT dbSNP:rs41545519). FT /FTId=VAR_033149. FT VARIANT 199 199 G -> R (in allele A*03:04; FT dbSNP:rs41559916). FT /FTId=VAR_016605. FT VARIANT 205 205 R -> H (in dbSNP:rs17185861). FT /FTId=VAR_050320. FT CONFLICT 319 319 G -> A (in Ref. 8; AAB66582). FT {ECO:0000305}. FT STRAND 27 36 {ECO:0000244|PDB:3RL1}. FT STRAND 41 43 {ECO:0000244|PDB:3RL1}. FT STRAND 45 52 {ECO:0000244|PDB:3RL1}. FT STRAND 55 61 {ECO:0000244|PDB:3RL1}. FT STRAND 64 66 {ECO:0000244|PDB:3RL1}. FT HELIX 74 76 {ECO:0000244|PDB:3RL1}. FT HELIX 81 108 {ECO:0000244|PDB:3RL1}. FT STRAND 113 115 {ECO:0000244|PDB:3RL1}. FT STRAND 118 127 {ECO:0000244|PDB:3RL1}. FT STRAND 133 142 {ECO:0000244|PDB:3RL1}. FT STRAND 145 150 {ECO:0000244|PDB:3RL1}. FT STRAND 157 161 {ECO:0000244|PDB:3RL1}. FT HELIX 162 173 {ECO:0000244|PDB:3RL1}. FT HELIX 176 184 {ECO:0000244|PDB:3RL1}. FT HELIX 187 198 {ECO:0000244|PDB:3RL1}. FT HELIX 200 203 {ECO:0000244|PDB:3RL1}. FT STRAND 210 217 {ECO:0000244|PDB:3RL1}. FT STRAND 219 235 {ECO:0000244|PDB:3RL1}. FT STRAND 238 243 {ECO:0000244|PDB:3RL1}. FT STRAND 251 254 {ECO:0000244|PDB:3RL1}. FT STRAND 261 263 {ECO:0000244|PDB:3RL1}. FT STRAND 265 274 {ECO:0000244|PDB:3RL1}. FT HELIX 278 280 {ECO:0000244|PDB:3RL1}. FT STRAND 281 286 {ECO:0000244|PDB:3RL1}. FT STRAND 290 292 {ECO:0000244|PDB:3RL2}. FT STRAND 294 297 {ECO:0000244|PDB:3RL1}. SQ SEQUENCE 365 AA; 40841 MW; DEDFCEC4450E0580 CRC64; MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV DLGTLRGYYN QSEAGSHTIQ IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAAHEAEQL RAYLDGTCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL TACKV // ID 1A03_PANTR Reviewed; 365 AA. AC P13748; Q547D5; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 2. DT 20-JUN-2018, entry version 118. DE RecName: Full=Patr class I histocompatibility antigen, A-108 alpha chain; DE AltName: Full=ChLa class I histocompatibility antigen, A-108 alpha chain; DE AltName: Full=MHC class I antigen Patr-A*0301; DE Flags: Precursor; GN Name=Patr-A; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=12021342; DOI=10.1128/JVI.76.12.6093-6103.2002; RA Mizukoshi E., Nascimbeni M., Blaustein J.B., Mihalik K., Rice C.M., RA Liang T.J., Feinstone S.M., Rehermann B.; RT "Molecular and immunological significance of chimpanzee major RT histocompatibility complex haplotypes for hepatitis C virus immune RT response and vaccination studies."; RL J. Virol. 76:6093-6103(2002). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 2-365. RX PubMed=2460344; RA Mayer W.E., Jonker M., Klein D., Ivanyi P., van Seventer G., Klein J.; RT "Nucleotide sequences of chimpanzee MHC class I alleles: evidence for RT trans-species mode of evolution."; RL EMBO J. 7:2765-2774(1988). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AF500288; AAM49754.1; -; mRNA. DR EMBL; X13113; CAA31505.1; -; mRNA. DR PIR; S03535; S03535. DR RefSeq; NP_001009058.3; NM_001009058.3. DR UniGene; Ptr.2590; -. DR ProteinModelPortal; P13748; -. DR SMR; P13748; -. DR STRING; 9598.ENSPTRP00000055208; -. DR PaxDb; P13748; -. DR PRIDE; P13748; -. DR GeneID; 750725; -. DR CTD; 750725; -. DR HOVERGEN; HBG016709; -. DR InParanoid; P13748; -. DR Proteomes; UP000002277; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 365 Patr class I histocompatibility antigen, FT A-108 alpha chain. FT /FTId=PRO_0000018912. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000250|UniProtKB:P04439}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000250|UniProtKB:P04439}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000250|UniProtKB:P04439}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 365 AA; 40823 MW; 48CC757055221FC3 CRC64; MAVMPPRTLL LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN MKASAQTDRV DLGTLRGYYN QSEDGSHTIQ IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA AMAAQITKRK WEAAHAAEQL RAYLEGRCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAVITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL TACKV // ID 1A04_GORGO Reviewed; 365 AA. AC P30378; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 28-FEB-2018, entry version 99. DE RecName: Full=Class I histocompatibility antigen, Gogo-A*0501 alpha chain; DE Flags: Precursor; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1744581; DOI=10.1084/jem.174.6.1491; RA Lawlor D.A., Warren E., Taylor P., Parham P.; RT "Gorilla class I major histocompatibility complex alleles: comparison RT to human and chimpanzee class I."; RL J. Exp. Med. 174:1491-1509(1991). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X60256; CAA42808.1; -; mRNA. DR PIR; JH0537; JH0537. DR RefSeq; NP_001266480.1; NM_001279551.1. DR ProteinModelPortal; P30378; -. DR SMR; P30378; -. DR STRING; 9593.ENSGGOP00000005655; -. DR PRIDE; P30378; -. DR GeneID; 101141279; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000001519; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 365 Class I histocompatibility antigen, Gogo- FT A*0501 alpha chain. FT /FTId=PRO_0000018900. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P10314}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P10314}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000250|UniProtKB:P10314}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P10314}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000250|UniProtKB:P10314}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000250|UniProtKB:P10314}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000250|UniProtKB:P10314}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 365 AA; 40896 MW; 340DAD21F9B3B8AB CRC64; MAVVAPRTLL LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWMEQEE PEYWDRQTQI SKTNAQIELE SLRIALRYYN QSEDGSHTIQ RMYGCDVGSD GRFLRGYQQD AYDGKDYIAS NEDLRSWTAA DMAAEITKRK WEAAHFAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THTTHQAVSD HEATLKCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDVSL TACKV // ID 1A04_PANTR Reviewed; 365 AA. AC P13749; Q7JJU4; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 28-FEB-2018, entry version 109. DE RecName: Full=Patr class I histocompatibility antigen, A-126 alpha chain; DE AltName: Full=ChLa class I histocompatibility antigen, A-126 alpha chain; DE AltName: Full=MHC class I antigen Patr-A*0401; DE Flags: Precursor; GN Name=Patr-A; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2460344; RA Mayer W.E., Jonker M., Klein D., Ivanyi P., van Seventer G., Klein J.; RT "Nucleotide sequences of chimpanzee MHC class I alleles: evidence for RT trans-species mode of evolution."; RL EMBO J. 7:2765-2774(1988). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Blood; RX PubMed=10866106; DOI=10.1007/s002510050638; RA de Groot N.G., Otting N., Arguello R., Watkins D.I., Doxiadis G.G., RA Madrigal J.A., Bontrop R.E.; RT "Major histocompatibility complex class I diversity in a West African RT chimpanzee population: implications for HIV research."; RL Immunogenetics 51:398-409(2000). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12799463; DOI=10.1073/pnas.1230533100; RA Anzai T., Shiina T., Kimura N., Yanagiya K., Kohara S., Shigenari A., RA Yamagata T., Kulski J.K., Naruse T.K., Fujimori Y., Fukuzumi Y., RA Yamazaki M., Tashiro H., Iwamoto C., Umehara Y., Imanishi T., RA Meyer A., Ikeo K., Gojobori T., Bahram S., Inoko H.; RT "Comparative sequencing of human and chimpanzee MHC class I regions RT unveils insertions/deletions as the major path to genomic RT divergence."; RL Proc. Natl. Acad. Sci. U.S.A. 100:7708-7713(2003). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X13114; CAA31506.1; -; mRNA. DR EMBL; AF168401; AAF72782.1; -; mRNA. DR EMBL; BA000041; BAC78189.1; -; Genomic_DNA. DR PIR; S01171; S01171. DR UniGene; Ptr.2590; -. DR ProteinModelPortal; P13749; -. DR SMR; P13749; -. DR STRING; 9598.ENSPTRP00000056399; -. DR PaxDb; P13749; -. DR PRIDE; P13749; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000002277; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 365 Patr class I histocompatibility antigen, FT A-126 alpha chain. FT /FTId=PRO_0000018913. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P10314}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P10314}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000250|UniProtKB:P10314}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P10314}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000250|UniProtKB:P10314}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000250|UniProtKB:P10314}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000250|UniProtKB:P10314}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 365 AA; 40656 MW; D3C9A810B22A768F CRC64; MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDEETRS VKASAQTDRV DLGTLRGYYN QSEDGSHTIQ LMFGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAAHAAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD REATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDVSL TACKV // ID 1A11_HUMAN Reviewed; 365 AA. AC P13746; O19605; O19606; Q29747; Q29835; Q5S3G1; Q9BCN0; Q9MYI5; AC Q9TQE9; Q9TQP6; Q9TQP7; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 12-SEP-2018, entry version 163. DE RecName: Full=HLA class I histocompatibility antigen, A-11 alpha chain; DE AltName: Full=MHC class I antigen A*11; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES A*11:01 AND A*11:02). RX PubMed=2460344; RA Mayer W.E., Jonker M., Klein D., Ivanyi P., van Seventer G., Klein J.; RT "Nucleotide sequences of chimpanzee MHC class I alleles: evidence for RT trans-species mode of evolution."; RL EMBO J. 7:2765-2774(1988). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES A*11:01 AND A*11:02). RX PubMed=8016845; DOI=10.1111/j.1399-0039.1994.tb02304.x; RA Lin L., Tokunaga K., Ishikawa Y., Bannai M., Kashiwase K., Kuwata S., RA Akaza T., Tadokoro K., Shibata Y., Juji T.; RT "Sequence analysis of serological HLA-A11 split antigens, A11.1 and RT A11.2."; RL Tissue Antigens 43:78-82(1994). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*11:05). RX PubMed=10395112; DOI=10.1034/j.1399-0039.1999.530612.x; RA Morrell G., Whalley J., Stewart A., Day S., Lewis L., Makar Y., RA Ross J., Dunn P.P.; RT "Identification of an HLA-A11 serological variant and its RT characterization by sequencing based typing."; RL Tissue Antigens 53:591-594(1999). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*11:03). RC TISSUE=Blood; RX PubMed=10703613; DOI=10.1034/j.1399-0039.2000.550113.x; RA Tijssen H.J., Sistermans E.A., van den Beucken M.J.G., Krausa P., RA Joosten I.; RT "Complete sequence analysis of the A*1103 allele."; RL Tissue Antigens 55:68-70(2000). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*11:03). RC TISSUE=Blood; RX PubMed=10885562; DOI=10.1034/j.1399-0039.2000.550504.x; RA Tijssen H.J., Sistermans E.A., Joosten I.; RT "A unique second donor splice site in the intron 5 sequence of the RT HLA-A*11 alleles results in a class I transcript encoding a molecule RT with an elongated cytoplasmic domain."; RL Tissue Antigens 55:422-428(2000). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE A*11:05). RX PubMed=10852390; DOI=10.1034/j.1399-0039.2000.550412.x; RA Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R., RA Ng J., Hartzman R.J., Hurley C.K.; RT "Seventeen more novel HLA-A locus alleles."; RL Tissue Antigens 55:369-373(2000). RN [7] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*11:07). RX PubMed=11703829; DOI=10.1034/j.1399-0039.2001.580309.x; RA Pyo C.W., Choi H.B., Han H., Hong Y.S., Kim T.G.; RT "Identification of HLA-A*11 variant (A*1107) in the Korean RT population."; RL Tissue Antigens 58:190-192(2001). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*11:04) (ISOFORM 2). RX PubMed=17092262; DOI=10.1111/j.1399-0039.2006.00687.x; RA Sun Y., Liu S., Luo Y., Liang F., Xi Y.; RT "Identification and frequency of a novel HLA-A allele, A*110104."; RL Tissue Antigens 68:453-454(2006). RN [9] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*11:04) (ISOFORM 2). RA Xu L.-H., Chi X.-Y., Jia Q.-T., Li F.-Y., Zha Q.-B., He X.-H.; RT "Cloning of high frequency HLA-B alleles from Chinese population."; RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*11:04). RA Bettinotti M.P.; RL Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases. RN [11] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-365 (ALLELE A*11:01). RX PubMed=2437024; DOI=10.1007/BF00404694; RA Cowan E.P., Jelachich M.L., Biddison W.E., Coligan J.E.; RT "DNA sequence of HLA-A11: remarkable homology with HLA-A3 allows RT identification of residues involved in epitopes recognized by RT antibodies and T cells."; RL Immunogenetics 25:241-250(1987). RN [12] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE A*11:04). RA Chandanayingyong D., Sirikong M., Luangtrakool K., Srinak D., RA Rungroung E., Bejchandra S.; RT "A11 alleles (A*11O4)."; RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases. RN [13] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, VARIANT [LARGE RP SCALE ANALYSIS] SER-345, AND IDENTIFICATION BY MASS SPECTROMETRY RP [LARGE SCALE ANALYSIS]. RC TISSUE=Platelet; RX PubMed=18088087; DOI=10.1021/pr0704130; RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., RA Schuetz C., Walter U., Gambaryan S., Sickmann A.; RT "Phosphoproteome of resting human platelets."; RL J. Proteome Res. 7:526-534(2008). RN [14] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356 AND SER-359, VARIANT RP [LARGE SCALE ANALYSIS] SER-345, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [15] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350; SER-352; SER-356 RP AND SER-359, VARIANT [LARGE SCALE ANALYSIS] SER-345, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [16] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [17] RP X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 25-299 (ALLELE A*11:01) IN RP COMPLEX WITH SARS NUCLEOCAPSID PEPTIDE, AND DISULFIDE BONDS. RX PubMed=16041067; DOI=10.1107/S0907444905013090; RA Blicher T., Kastrup J.S., Buus S., Gajhede M.; RT "High-resolution structure of HLA-A*1101 in complex with SARS RT nucleocapsid peptide."; RL Acta Crystallogr. D 61:1031-1040(2005). RN [18] RP VARIANT [LARGE SCALE ANALYSIS] SER-345, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., RA Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in RT a refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [19] RP VARIANT [LARGE SCALE ANALYSIS] THR-166, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=P13746-1; Sequence=Displayed; CC Name=2; Synonyms=Long; CC IsoId=P13746-2; Sequence=VSP_008099; CC Note=Only produced by allele A*1103.; CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of A-11 are known: A*11:01 (A- CC 11E), A*11:02 (A-11K), A*11:03, A*11:04, A*11:05 and A*11:07. The CC sequence shown is that of A*11:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X13111; CAA31503.1; -; mRNA. DR EMBL; X13112; CAA31504.1; -; mRNA. DR EMBL; D16841; BAA04117.1; -; mRNA. DR EMBL; D16842; BAA04118.1; -; mRNA. DR EMBL; AJ306733; CAC37336.1; -; Genomic_DNA. DR EMBL; X91399; CAA62745.1; -; mRNA. DR EMBL; Y17224; CAB38056.1; -; mRNA. DR EMBL; Y17224; CAB38057.1; -; mRNA. DR EMBL; AH007763; AAD33991.1; -; Genomic_DNA. DR EMBL; AF165065; AAF25781.1; -; mRNA. DR EMBL; DQ336694; ABC59611.1; -; mRNA. DR EMBL; AY786586; AAV53344.1; -; mRNA. DR EMBL; AY786587; AAV53345.1; -; mRNA. DR EMBL; U50574; AAB60406.1; -; mRNA. DR EMBL; AH003070; AAA65449.1; -; Genomic_DNA. DR EMBL; AH005647; AAB87052.1; -; Genomic_DNA. DR EMBL; AH005646; AAB87051.1; -; Genomic_DNA. DR PIR; I83063; I83063. DR PIR; S03536; A47636. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR PDB; 1Q94; X-ray; 2.40 A; A/D=25-299. DR PDB; 1QVO; X-ray; 2.22 A; A/D=25-299. DR PDB; 1X7Q; X-ray; 1.45 A; A=25-299. DR PDB; 2HN7; X-ray; 1.60 A; A=25-299. DR PDB; 4MJ5; X-ray; 2.40 A; A=25-298. DR PDB; 4MJ6; X-ray; 2.57 A; A=25-298. DR PDB; 4N8V; X-ray; 2.50 A; A/D=25-298. DR PDB; 4UQ2; X-ray; 2.43 A; A/C=25-299. DR PDB; 5GRD; X-ray; 1.80 A; A=25-299. DR PDB; 5GRG; X-ray; 1.94 A; A=25-299. DR PDB; 5GSD; X-ray; 2.30 A; A=25-299. DR PDB; 5WJL; X-ray; 3.15 A; A/D/G=25-298. DR PDB; 5WJN; X-ray; 2.85 A; A/D/G=25-298. DR PDB; 5WKF; X-ray; 2.95 A; A/F=25-298. DR PDB; 5WKH; X-ray; 3.20 A; A/F=25-298. DR PDBsum; 1Q94; -. DR PDBsum; 1QVO; -. DR PDBsum; 1X7Q; -. DR PDBsum; 2HN7; -. DR PDBsum; 4MJ5; -. DR PDBsum; 4MJ6; -. DR PDBsum; 4N8V; -. DR PDBsum; 4UQ2; -. DR PDBsum; 5GRD; -. DR PDBsum; 5GRG; -. DR PDBsum; 5GSD; -. DR PDBsum; 5WJL; -. DR PDBsum; 5WJN; -. DR PDBsum; 5WKF; -. DR PDBsum; 5WKH; -. DR ProteinModelPortal; P13746; -. DR SMR; P13746; -. DR IntAct; P13746; 7. DR iPTMnet; P13746; -. DR PhosphoSitePlus; P13746; -. DR SwissPalm; P13746; -. DR DMDM; 122157; -. DR EPD; P13746; -. DR MaxQB; P13746; -. DR PeptideAtlas; P13746; -. DR PRIDE; P13746; -. DR Ensembl; ENST00000376809; ENSP00000366005; ENSG00000206503. DR Ensembl; ENST00000396634; ENSP00000379873; ENSG00000206503. DR DisGeNET; 3105; -. DR EuPathDB; HostDB:ENSG00000206503.11; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR HPA; CAB078470; -. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P13746; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR EvolutionaryTrace; P13746; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000206503; Expressed in 239 organ(s), highest expression level in mononuclear cell. DR CleanEx; HS_HLA-A; -. DR ExpressionAtlas; P13746; baseline and differential. DR Genevisible; P13746; HS. DR GO; GO:0009986; C:cell surface; IDA:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; IDA:UniProtKB. DR GO; GO:0046977; F:TAP binding; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0042270; P:protection from natural killer cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Complete proteome; Disulfide bond; KW Glycoprotein; Immunity; Membrane; MHC I; Phosphoprotein; Polymorphism; KW Reference proteome; Signal; Transmembrane; Transmembrane helix; KW Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-11 alpha chain. FT /FTId=PRO_0000018816. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:18088087, FT ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:16041067}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:16041067}. FT VAR_SEQ 337 337 S -> SGGEGVK (in isoform 2). FT {ECO:0000303|PubMed:17092262, FT ECO:0000303|Ref.9}. FT /FTId=VSP_008099. FT VARIANT 43 43 E -> K (in allele A*11:02). FT /FTId=VAR_004353. FT VARIANT 89 89 R -> G (in dbSNP:rs199474430). FT /FTId=VAR_056254. FT VARIANT 94 94 Q -> H (in dbSNP:rs78306866). FT /FTId=VAR_056255. FT VARIANT 101 101 D -> N (in dbSNP:rs1136688). FT /FTId=VAR_056256. FT VARIANT 131 131 G -> W (in dbSNP:rs1136702). FT /FTId=VAR_056257. FT VARIANT 133 133 F -> L (in allele A*11:07; FT dbSNP:rs1059488). FT /FTId=VAR_016731. FT VARIANT 151 151 N -> K (in dbSNP:rs1059509). FT /FTId=VAR_056258. FT VARIANT 166 166 I -> T (in dbSNP:rs1059516). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056259. FT VARIANT 168 168 K -> E (in allele A*11:05). FT /FTId=VAR_016732. FT VARIANT 169 169 R -> H (in dbSNP:rs1059520). FT /FTId=VAR_056260. FT VARIANT 175 175 H -> R (in allele A*11:03). FT /FTId=VAR_016733. FT VARIANT 176 176 A -> E (in allele A*11:03). FT /FTId=VAR_016734. FT VARIANT 187 187 R -> T (in allele A*11:04). FT /FTId=VAR_016735. FT VARIANT 205 205 R -> H (in dbSNP:rs17185861). FT /FTId=VAR_056261. FT VARIANT 345 345 T -> S (in allele A*11:05). FT {ECO:0000244|PubMed:18088087, FT ECO:0000244|PubMed:19413330, FT ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569}. FT /FTId=VAR_016736. FT STRAND 27 36 {ECO:0000244|PDB:1X7Q}. FT STRAND 41 43 {ECO:0000244|PDB:1X7Q}. FT STRAND 45 52 {ECO:0000244|PDB:1X7Q}. FT STRAND 55 61 {ECO:0000244|PDB:1X7Q}. FT STRAND 64 66 {ECO:0000244|PDB:1X7Q}. FT HELIX 74 76 {ECO:0000244|PDB:1X7Q}. FT HELIX 81 108 {ECO:0000244|PDB:1X7Q}. FT STRAND 113 115 {ECO:0000244|PDB:1X7Q}. FT STRAND 118 127 {ECO:0000244|PDB:1X7Q}. FT STRAND 133 142 {ECO:0000244|PDB:1X7Q}. FT STRAND 145 150 {ECO:0000244|PDB:1X7Q}. FT STRAND 157 159 {ECO:0000244|PDB:1X7Q}. FT HELIX 162 173 {ECO:0000244|PDB:1X7Q}. FT HELIX 176 185 {ECO:0000244|PDB:1X7Q}. FT HELIX 187 198 {ECO:0000244|PDB:1X7Q}. FT HELIX 200 203 {ECO:0000244|PDB:1X7Q}. FT STRAND 210 217 {ECO:0000244|PDB:1X7Q}. FT STRAND 219 235 {ECO:0000244|PDB:1X7Q}. FT STRAND 238 243 {ECO:0000244|PDB:1X7Q}. FT STRAND 246 248 {ECO:0000244|PDB:2HN7}. FT HELIX 249 251 {ECO:0000244|PDB:5GRD}. FT STRAND 252 254 {ECO:0000244|PDB:1X7Q}. FT STRAND 261 263 {ECO:0000244|PDB:1X7Q}. FT STRAND 265 274 {ECO:0000244|PDB:1X7Q}. FT HELIX 278 280 {ECO:0000244|PDB:1X7Q}. FT STRAND 281 286 {ECO:0000244|PDB:1X7Q}. FT STRAND 288 292 {ECO:0000244|PDB:1QVO}. FT STRAND 294 297 {ECO:0000244|PDB:1X7Q}. SQ SEQUENCE 365 AA; 40937 MW; FE449CE2D4BF6CC5 CRC64; MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV DLGTLRGYYN QSEDGSHTIQ IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAAHAAEQQ RAYLEGRCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL TACKV // ID 1A23_HUMAN Reviewed; 365 AA. AC P30447; Q9TQF1; Q9TQF8; Q9TQG5; Q9TQM6; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 147. DE RecName: Full=HLA class I histocompatibility antigen, A-23 alpha chain; DE AltName: Full=HLA class I histocompatibility antigen, A-9 alpha chain; DE AltName: Full=MHC class I antigen A*23; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE A*23:01). RX PubMed=1729171; DOI=10.1007/BF00216625; RA Little A.-M., Madrigal J.A., Parham P.; RT "Molecular definition of an elusive third HLA-A9 molecule: HLA-A9.3."; RL Immunogenetics 35:41-45(1992). RN [2] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*23:02 AND A*23:03). RX PubMed=10852390; DOI=10.1034/j.1399-0039.2000.550412.x; RA Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R., RA Ng J., Hartzman R.J., Hurley C.K.; RT "Seventeen more novel HLA-A locus alleles."; RL Tissue Antigens 55:369-373(2000). RN [3] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*23:04 AND A*23:05). RX PubMed=11169246; DOI=10.1034/j.1399-0039.2000.560610.x; RA Steiner N.K., Edson S.M., Mitton W., Ng J., Hartzman R.J., RA Hurley C.K.; RT "Seven novel HLA-A alleles carry previously observed polymorphisms."; RL Tissue Antigens 56:551-552(2000). RN [4] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Platelet; RX PubMed=18088087; DOI=10.1021/pr0704130; RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., RA Schuetz C., Walter U., Gambaryan S., Sickmann A.; RT "Phosphoproteome of resting human platelets."; RL J. Proteome Res. 7:526-534(2008). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., RA Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in RT a refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356 AND SER-359, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [8] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350; SER-352; SER-356 RP AND SER-359, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of A-23 are known: A*23:01, CC A*23:02, A*23:03, A*23:04 and A*23:05. The sequence shown is that CC of A*23:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M64742; AAA03662.1; -; mRNA. DR EMBL; AH007754; AAD33736.1; -; Genomic_DNA. DR EMBL; AH007619; AAD28171.1; -; Genomic_DNA. DR EMBL; AH007540; AAD22272.1; -; Genomic_DNA. DR EMBL; AH007726; AAD31878.1; -; Genomic_DNA. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR ProteinModelPortal; P30447; -. DR SMR; P30447; -. DR IntAct; P30447; 3. DR iPTMnet; P30447; -. DR SwissPalm; P30447; -. DR DMDM; 231359; -. DR EPD; P30447; -. DR MaxQB; P30447; -. DR PeptideAtlas; P30447; -. DR PRIDE; P30447; -. DR Ensembl; ENST00000454091; ENSP00000410645; ENSG00000223980. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P30447; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0042270; P:protection from natural killer cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-23 alpha chain. FT /FTId=PRO_0000018817. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:18088087, FT ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 31 31 Y -> C (in allele A*23:05). FT /FTId=VAR_016606. FT VARIANT 151 151 K -> N (in allele A*23:03). FT /FTId=VAR_016607. FT VARIANT 180 180 L -> W (in allele A*23:02). FT /FTId=VAR_016608. FT VARIANT 190 191 DG -> EW (in allele A*23:04). FT /FTId=VAR_016609. FT VARIANT 205 205 R -> H (in dbSNP:rs17185861). FT /FTId=VAR_056262. SQ SEQUENCE 365 AA; 40733 MW; C372DE503BF393D0 CRC64; MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDEETGK VKAHSQTDRE NLRIALRYYN QSEAGSHTLQ MMFGCDVGSD GRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQITQRK WEAARVAEQL RAYLEGTCVD GLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQPTVHIVG IIAGLVLLGA VITGAVVAAV MWRRNSSDRK GGSYSQAASS DSAQGSDVSL TACKV // ID 1A24_HUMAN Reviewed; 365 AA. AC P05534; P30448; P30449; Q29908; Q29909; Q29910; Q95355; DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot. DT 27-JUN-2003, sequence version 2. DT 12-SEP-2018, entry version 178. DE RecName: Full=HLA class I histocompatibility antigen, A-24 alpha chain; DE AltName: Full=Aw-24; DE AltName: Full=HLA class I histocompatibility antigen, A-9 alpha chain; DE AltName: Full=MHC class I antigen A*24; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*24:01). RX PubMed=2987115; DOI=10.1007/BF00430931; RA N'Guyen C., Sodoyer R., Trucy J., Strachan T., Jordan B.R.; RT "The HLA-AW24 gene: sequence, surroundings and comparison with the RT HLA-A2 and HLA-A3 genes."; RL Immunogenetics 21:479-489(1985). RN [2] RP SEQUENCE REVISION. RA Jordan B.R.; RL Submitted (JUL-1988) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ALLELES A*24:02 AND RP A*24:03). RX PubMed=1729171; DOI=10.1007/BF00216625; RA Little A.-M., Madrigal J.A., Parham P.; RT "Molecular definition of an elusive third HLA-A9 molecule: HLA-A9.3."; RL Immunogenetics 35:41-45(1992). RN [4] RP NUCLEOTIDE SEQUENCE (ALLELE A*24:02). RX PubMed=1317015; DOI=10.1038/357326a0; RA Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J., RA Williams R.C., Luz R., Petzl-Erler M.L., Parham P.; RT "Unusual HLA-B alleles in two tribes of Brazilian Indians."; RL Nature 357:326-329(1992). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*24:02). RX PubMed=9349616; DOI=10.1111/j.1399-0039.1997.tb02884.x; RA Laforet M., Froelich N., Parissiadis A., Bausinger H., Pfeiffer B., RA Tongio M.M.; RT "An intronic mutation responsible for a low level of expression of an RT HLA-A*24 allele."; RL Tissue Antigens 50:340-346(1997). RN [6] RP NUCLEOTIDE SEQUENCE (ALLELE A*24:08). RC TISSUE=Blood; RA Kashiwase K., Tokunaga K., Ishikawa Y., Qiu L., Furuya M., RA Sawanaka K., Akaza T., Tadokoro K., Juji T.; RT "Sequence analysis of a serological subtype, HLA-A9HH, observed in RT Japanese and the confirmatory sequence of A*2408."; RL MHC 3:9-14(1996). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-337 (ALLELE A*24:29). RA Dunn P.; RT "Confirmation of the sequence of HLA-A*2429 allele found in a RT potential bone marrow donor."; RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE A*24:10). RC TISSUE=Blood; RX PubMed=9008316; DOI=10.1111/j.1399-0039.1996.tb02697.x; RA Gao X., Matheson B.; RT "A novel HLA-A*24 (A*2410) identified in a Javanese population."; RL Tissue Antigens 48:711-713(1996). RN [9] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES A*24:06; A*24:13 RP AND A*24:14). RC TISSUE=Blood; RX PubMed=9271829; DOI=10.1111/j.1399-0039.1997.tb02858.x; RA Gao X., Lester S., Matheson B., Boettcher B., McCluskey J.; RT "Three newly identified A*24 alleles: A*2406, A*2413 and A*2414."; RL Tissue Antigens 50:192-196(1997). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Platelet; RX PubMed=18088087; DOI=10.1021/pr0704130; RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., RA Schuetz C., Walter U., Gambaryan S., Sickmann A.; RT "Phosphoproteome of resting human platelets."; RL J. Proteome Res. 7:526-534(2008). RN [11] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., RA Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in RT a refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [12] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110. RC TISSUE=Liver; RX PubMed=19159218; DOI=10.1021/pr8008012; RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; RT "Glycoproteomics analysis of human liver tissue by combination of RT multiple enzyme digestion and hydrazide chemistry."; RL J. Proteome Res. 8:651-661(2009). RN [13] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356 AND SER-359, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [14] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350; SER-352; SER-356 RP AND SER-359, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [15] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [16] RP X-RAY CRYSTALLOGRAPHY (2.39 ANGSTROMS) OF 25-298 (ALLELE A*24:02) IN RP COMPLEX WITH B2M AND CD8, AND DISULFIDE BONDS. RX PubMed=21645925; DOI=10.1016/j.molimm.2011.05.009; RA Shi Y., Qi J., Iwamoto A., Gao G.F.; RT "Plasticity of human CD8alphaalpha binding to peptide-HLA-A*2402."; RL Mol. Immunol. 48:2198-2202(2011). RN [17] RP VARIANT [LARGE SCALE ANALYSIS] TRP-180, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of A-24 are known: A*24:01, CC A*24:02, A*24:03, A*24:06, A*24:08 (A9HH), A*24:10 (A*24JV), CC A*24:13 (A*24YM), A*24:14 (A*24SA) and A*24:29. Allele A*24:02 is CC represented in all major racial groups. Allele A*24:06 and allele CC A*24:13 are found in the Australian Aboriginal population. Allele CC A*24:14 is found in individuals of South American descent. The CC sequence shown is that of A*24:02. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M15497; AAA59611.1; -; Genomic_DNA. DR EMBL; M64740; AAA59600.1; -; mRNA. DR EMBL; M64741; AAA59601.1; -; Genomic_DNA. DR EMBL; Z72422; CAA96532.1; -; Genomic_DNA. DR EMBL; D83516; BAA11936.1; -; mRNA. DR EMBL; U37111; AAA83264.1; -; Genomic_DNA. DR EMBL; U37110; AAA83264.1; JOINED; Genomic_DNA. DR EMBL; U37113; AAA83265.1; -; Genomic_DNA. DR EMBL; U37112; AAA83265.1; JOINED; Genomic_DNA. DR EMBL; AH004915; AAB40048.1; -; Genomic_DNA. DR EMBL; AH005378; AAB60651.1; -; Genomic_DNA. DR PIR; I54416; I54416. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR PDB; 2BCK; X-ray; 2.80 A; A/D=25-300. DR PDB; 3I6L; X-ray; 2.40 A; D=25-298. DR PDB; 3NFN; X-ray; 2.39 A; A=25-298. DR PDB; 3QZW; X-ray; 2.80 A; A/D=25-298. DR PDB; 3VXM; X-ray; 2.50 A; A=25-298. DR PDB; 3VXN; X-ray; 1.95 A; A=25-298. DR PDB; 3VXO; X-ray; 2.61 A; A/D=25-298. DR PDB; 3VXP; X-ray; 2.50 A; A/D=25-298. DR PDB; 3VXR; X-ray; 2.40 A; A=25-298. DR PDB; 3VXS; X-ray; 1.80 A; A=25-298. DR PDB; 3VXU; X-ray; 2.70 A; A/F=25-298. DR PDB; 3W0W; X-ray; 2.60 A; A=25-298. DR PDB; 3WL9; X-ray; 1.66 A; A=25-298. DR PDB; 3WLB; X-ray; 2.00 A; A=25-298. DR PDB; 4F7M; X-ray; 2.40 A; A/D=25-298. DR PDB; 4F7P; X-ray; 1.90 A; A=25-298. DR PDB; 4F7T; X-ray; 1.70 A; A/D=25-298. DR PDB; 4WU5; X-ray; 2.40 A; A/D=25-298. DR PDB; 4WU7; X-ray; 2.30 A; A/D=25-298. DR PDB; 5HGA; X-ray; 2.20 A; A/D=25-298. DR PDB; 5HGB; X-ray; 2.40 A; A/D/G/J=25-298. DR PDB; 5HGD; X-ray; 2.07 A; A/D=25-298. DR PDB; 5HGH; X-ray; 2.39 A; A=25-298. DR PDB; 5WWI; X-ray; 3.19 A; A=25-298. DR PDB; 5WWJ; X-ray; 2.29 A; A/C=25-298. DR PDB; 5WWU; X-ray; 2.79 A; A=25-298. DR PDB; 5WXC; X-ray; 2.29 A; A/C=25-298. DR PDB; 5WXD; X-ray; 3.29 A; A=25-298. DR PDB; 5XOV; X-ray; 2.68 A; A/D=25-298. DR PDBsum; 2BCK; -. DR PDBsum; 3I6L; -. DR PDBsum; 3NFN; -. DR PDBsum; 3QZW; -. DR PDBsum; 3VXM; -. DR PDBsum; 3VXN; -. DR PDBsum; 3VXO; -. DR PDBsum; 3VXP; -. DR PDBsum; 3VXR; -. DR PDBsum; 3VXS; -. DR PDBsum; 3VXU; -. DR PDBsum; 3W0W; -. DR PDBsum; 3WL9; -. DR PDBsum; 3WLB; -. DR PDBsum; 4F7M; -. DR PDBsum; 4F7P; -. DR PDBsum; 4F7T; -. DR PDBsum; 4WU5; -. DR PDBsum; 4WU7; -. DR PDBsum; 5HGA; -. DR PDBsum; 5HGB; -. DR PDBsum; 5HGD; -. DR PDBsum; 5HGH; -. DR PDBsum; 5WWI; -. DR PDBsum; 5WWJ; -. DR PDBsum; 5WWU; -. DR PDBsum; 5WXC; -. DR PDBsum; 5WXD; -. DR PDBsum; 5XOV; -. DR ProteinModelPortal; P05534; -. DR SMR; P05534; -. DR IntAct; P05534; 5. DR iPTMnet; P05534; -. DR SwissPalm; P05534; -. DR DMDM; 32363482; -. DR EPD; P05534; -. DR MaxQB; P05534; -. DR PeptideAtlas; P05534; -. DR PRIDE; P05534; -. DR Ensembl; ENST00000431930; ENSP00000406366; ENSG00000229215. DR Ensembl; ENST00000443552; ENSP00000404678; ENSG00000224320. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR H-InvDB; HIX0165910; -. DR H-InvDB; HIX0165954; -. DR H-InvDB; HIX0166079; -. DR H-InvDB; HIX0166152; -. DR H-InvDB; HIX0166432; -. DR H-InvDB; HIX0166685; -. DR H-InvDB; HIX0166954; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P05534; -. DR HOVERGEN; HBG016709; -. DR PhylomeDB; P05534; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR EvolutionaryTrace; P05534; -. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0046977; F:TAP binding; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0042270; P:protection from natural killer cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Phosphoprotein; Polymorphism; KW Reference proteome; Signal; Transmembrane; Transmembrane helix; KW Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-24 alpha chain. FT /FTId=PRO_0000018818. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:18088087, FT ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:19159218}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:21645925}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:21645925}. FT VARIANT 5 5 A -> G (in allele A*24:01). FT {ECO:0000269|PubMed:2987115}. FT /FTId=VAR_004354. FT VARIANT 27 27 H -> Q (in allele A*24:08; FT dbSNP:rs41541319). {ECO:0000269|Ref.6}. FT /FTId=VAR_004355. FT VARIANT 86 86 E -> G (in allele A*24:08). FT {ECO:0000269|Ref.6}. FT /FTId=VAR_004356. FT VARIANT 89 89 G -> R (in allele A*24:08 and allele FT A*24:29). {ECO:0000269|Ref.6, FT ECO:0000269|Ref.7}. FT /FTId=VAR_004357. FT VARIANT 119 119 L -> V (in allele A*24:14). FT {ECO:0000269|PubMed:9271829}. FT /FTId=VAR_015765. FT VARIANT 121 121 M -> R (in allele A*24:14). FT {ECO:0000269|PubMed:9271829}. FT /FTId=VAR_015766. FT VARIANT 123 123 F -> Y (in allele A*24:14). FT {ECO:0000269|PubMed:9271829}. FT /FTId=VAR_015767. FT VARIANT 131 131 G -> W (in allele A*24:14). FT {ECO:0000269|PubMed:9271829}. FT /FTId=VAR_015768. FT VARIANT 180 180 Q -> L (in allele A*24:13). FT {ECO:0000269|PubMed:9271829}. FT /FTId=VAR_015769. FT VARIANT 180 180 Q -> W (in allele A*24:06; requires 2 FT nucleotide substitutions). FT {ECO:0000244|PubMed:21269460, FT ECO:0000269|PubMed:9271829}. FT /FTId=VAR_004358. FT VARIANT 187 187 T -> R (in allele A*24:10). FT {ECO:0000269|PubMed:9008316}. FT /FTId=VAR_015770. FT VARIANT 190 191 DG -> EW (in allele A*24:03 and allele FT A*24:10). {ECO:0000269|PubMed:1729171, FT ECO:0000269|PubMed:9008316}. FT /FTId=VAR_004359. FT VARIANT 205 205 R -> H (in dbSNP:rs17185861). FT /FTId=VAR_056263. FT VARIANT 206 206 T -> A (in allele A*24:01). FT {ECO:0000269|PubMed:2987115}. FT /FTId=VAR_004360. FT STRAND 27 36 {ECO:0000244|PDB:3WL9}. FT STRAND 41 43 {ECO:0000244|PDB:3WL9}. FT STRAND 45 52 {ECO:0000244|PDB:3WL9}. FT STRAND 55 61 {ECO:0000244|PDB:3WL9}. FT STRAND 64 66 {ECO:0000244|PDB:3WL9}. FT STRAND 70 73 {ECO:0000244|PDB:4F7T}. FT HELIX 74 76 {ECO:0000244|PDB:3WL9}. FT HELIX 81 109 {ECO:0000244|PDB:3WL9}. FT STRAND 113 115 {ECO:0000244|PDB:3VXS}. FT STRAND 118 127 {ECO:0000244|PDB:3WL9}. FT STRAND 133 142 {ECO:0000244|PDB:3WL9}. FT STRAND 145 150 {ECO:0000244|PDB:3WL9}. FT STRAND 157 159 {ECO:0000244|PDB:3WL9}. FT HELIX 162 173 {ECO:0000244|PDB:3WL9}. FT HELIX 176 185 {ECO:0000244|PDB:3WL9}. FT HELIX 187 198 {ECO:0000244|PDB:3WL9}. FT HELIX 200 203 {ECO:0000244|PDB:3WL9}. FT STRAND 210 235 {ECO:0000244|PDB:3WL9}. FT STRAND 238 243 {ECO:0000244|PDB:3WL9}. FT STRAND 246 248 {ECO:0000244|PDB:3WLB}. FT HELIX 249 251 {ECO:0000244|PDB:3WL9}. FT STRAND 252 254 {ECO:0000244|PDB:4F7T}. FT STRAND 261 263 {ECO:0000244|PDB:3WL9}. FT STRAND 265 274 {ECO:0000244|PDB:3WL9}. FT HELIX 278 280 {ECO:0000244|PDB:3WL9}. FT STRAND 281 286 {ECO:0000244|PDB:3WL9}. FT STRAND 290 292 {ECO:0000244|PDB:5WXC}. FT STRAND 294 297 {ECO:0000244|PDB:3WL9}. FT STRAND 298 300 {ECO:0000244|PDB:2BCK}. SQ SEQUENCE 365 AA; 40689 MW; D33684D126F98EC3 CRC64; MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDEETGK VKAHSQTDRE NLRIALRYYN QSEAGSHTLQ MMFGCDVGSD GRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQITKRK WEAAHVAEQQ RAYLEGTCVD GLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQPTVPIVG IIAGLVLLGA VITGAVVAAV MWRRNSSDRK GGSYSQAASS DSAQGSDVSL TACKV // ID 1A25_HUMAN Reviewed; 365 AA. AC P18462; Q95362; Q9TQE8; Q9TQG0; Q9UQU3; DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1990, sequence version 1. DT 12-SEP-2018, entry version 153. DE RecName: Full=HLA class I histocompatibility antigen, A-25 alpha chain; DE AltName: Full=HLA class I histocompatibility antigen, A-10 alpha chain; DE AltName: Full=MHC class I antigen A*25; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*25:01). RX PubMed=2320591; DOI=10.1073/pnas.87.7.2833; RA Ennis P.D., Zemmour J., Salter R.D., Parham P.; RT "Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: RT frequency and nature of errors produced in amplification."; RL Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE A*25:01). RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*25:02). RC TISSUE=Hematopoietic; RX PubMed=8881046; DOI=10.1007/s002510050175; RA Krausa P., Young D.M., Gotch F.; RT "Identification of a new HLA-A allele (A*2502) by PCR-SSP."; RL Immunogenetics 45:84-85(1996). RN [4] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*25:02). RA Guttridge M.G.; RT "Sequence confirmation of HLA-A*2502."; RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*25:03). RX PubMed=10852390; DOI=10.1034/j.1399-0039.2000.550412.x; RA Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R., RA Ng J., Hartzman R.J., Hurley C.K.; RT "Seventeen more novel HLA-A locus alleles."; RL Tissue Antigens 55:369-373(2000). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343; TYR-344; SER-345; RP SER-349; SER-352; SER-356 AND SER-359, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of A-25 are known: A*25:01 CC A*25:02 and A*25:03. The sequence shown is that of A*25:01. CC {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M32321; AAA36234.1; -; mRNA. DR EMBL; BC008611; AAH08611.1; -; mRNA. DR EMBL; X97802; CAA66389.1; -; mRNA. DR EMBL; AJ238524; CAB41888.1; -; Genomic_DNA. DR EMBL; AH007755; AAD33737.1; -; Genomic_DNA. DR EMBL; AH007764; AAD34010.1; -; Genomic_DNA. DR PIR; A35997; A35997. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR ProteinModelPortal; P18462; -. DR SMR; P18462; -. DR iPTMnet; P18462; -. DR SwissPalm; P18462; -. DR DMDM; 122158; -. DR MaxQB; P18462; -. DR PeptideAtlas; P18462; -. DR PRIDE; P18462; -. DR Ensembl; ENST00000383605; ENSP00000373100; ENSG00000206505. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P18462; -. DR HOVERGEN; HBG016709; -. DR PhylomeDB; P18462; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-25 alpha chain. FT /FTId=PRO_0000018819. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 33 33 Y -> F (in allele A*25:03; FT dbSNP:rs2075684). FT {ECO:0000269|PubMed:10852390}. FT /FTId=VAR_016737. FT VARIANT 94 94 H -> Q (in allele A*25:02). FT {ECO:0000269|PubMed:8881046, FT ECO:0000269|Ref.4}. FT /FTId=VAR_004361. FT VARIANT 151 151 N -> K (in dbSNP:rs1059509). FT /FTId=VAR_056264. FT VARIANT 166 166 I -> T (in dbSNP:rs1059516). FT /FTId=VAR_056265. SQ SEQUENCE 365 AA; 41218 MW; 00F71BD2F97C3620 CRC64; MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAHSQTDRE SLRIALRYYN QSEDGSHTIQ RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WETAHEAEQW RAYLEGRCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV // ID 1A26_HUMAN Reviewed; 365 AA. AC P30450; O02963; O78073; P79563; Q30208; Q31623; Q95377; Q9BD15; AC Q9BD19; Q9MW42; Q9TQK5; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1995, sequence version 2. DT 12-SEP-2018, entry version 165. DE RecName: Full=HLA class I histocompatibility antigen, A-26 alpha chain; DE AltName: Full=MHC class I antigen A*26; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELES A*26:01 AND A*26:02). RX PubMed=8475492; DOI=10.1111/j.1399-0039.1993.tb01982.x; RA Madrigal J.A., Hildebrand W.H., Belich M.P., Benjamin R.J., RA Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., RA du Toit E.D., Parham P.; RT "Structural diversity in the HLA-A10 family of alleles: correlations RT with serology."; RL Tissue Antigens 41:72-80(1993). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE A*26:01). RX PubMed=1692821; DOI=10.1016/0198-8859(90)90047-S; RA Zinzsner H., Masset M., Bourge J.-F., Colombani J., Cohen D., RA Degos L., Paul P.; RT "Nucleotide sequence of the HLA-A26 class I gene: identification of RT specific residues and molecular mapping of public HLA class I RT epitopes."; RL Hum. Immunol. 27:155-166(1990). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES A*26:01; A*26:02; A*26:03 AND RP A*26:04). RC TISSUE=Blood; RX PubMed=8026990; DOI=10.1016/0198-8859(94)90263-1; RA Ishikawa Y., Tokunaga K., Lin L., Imanishi T., Saitou S., RA Kashiwase K., Akaza T., Tadokoro K., Juji T.; RT "Sequences of four splits of HLA-A10 group. Implications for serologic RT cross-reactivities and their evolution."; RL Hum. Immunol. 39:220-224(1994). RN [4] RP NUCLEOTIDE SEQUENCE (ALLELE A*26:01). RC TISSUE=Lymphocyte; RA Miyashita H., Fujiyoshi T., Yashiki S., Kuwayama M., Fujiyama C., RA Sonoda S.; RL Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*26:03). RC TISSUE=Lymphocyte; RX PubMed=8838351; DOI=10.1111/j.1399-0039.1995.tb03134.x; RA Miyashita H., Fujiyoshi T., Yashiki S., Kuwayama M., Fujiyama C., RA Sonoda S.; RT "Cloning of HLA-A26 cDNA from Japanese donors possessing 'ATL- RT associated HLA haplotypes'."; RL Tissue Antigens 46:398-400(1995). RN [6] RP NUCLEOTIDE SEQUENCE (ALLELE A*26:05). RC TISSUE=Blood; RA Maruya E., Ishikawa Y., Lin L., Tokunaga K., Kimura A., Saitou S., RA Nita H., Juji T., Saji H.; RT "A novel A26 sequence found in Japanese, and identification of four RT major HLA-A26 subtypes."; RL Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*26:07). RX PubMed=8795143; DOI=10.1111/j.1399-0039.1996.tb02578.x; RA Arnett K.L., Moses J.H., Williams F., Marsh S.G.E., Bodmer J.G., RA Parham P., Middleton D.; RT "HLA-A *2607: sequence of a novel A*26 subtype predicted by DNA typing RT which shares the MA2.1 epitope with A*02, B*57 and B*58."; RL Tissue Antigens 47:422-425(1996). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*26:08). RX PubMed=8896181; DOI=10.1111/j.1399-0039.1996.tb02631.x; RA Szmania S., Baxter-Lowe L.A.; RT "Nucleotide sequence for HLA-A*2608 which encodes glutamine at codon RT 156."; RL Tissue Antigens 48:210-212(1996). RN [9] RP NUCLEOTIDE SEQUENCE (ALLELE A*26:08). RA Ellexson M.E., Hildebrand W.H.; RL Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*26:12). RX PubMed=11098929; DOI=10.1034/j.1399-0039.2000.560401.x; RA Ellis J.M., Mack S.J., Leke R.F.G., Quakyi I., Johnson A.H., RA Hurley C.K.; RT "Diversity is demonstrated in class I HLA-A and HLA-B alleles in RT Cameroon, Africa: description of HLA-A*03012, *2612, *3006 and HLA- RT B*1403, *4016, *4703."; RL Tissue Antigens 56:291-302(2000). RN [11] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*26:12). RX PubMed=11260503; DOI=10.1034/j.1399-0039.2001.057002095.x; RA Hickman H.D., Cavett J.W., Ellexson-Turner M.E., Sparkman J.N., RA Bennett T.T., Turner S., Sidebottom D.A., Trachtenberg E.A., RA Confer D.L., Hildebrand W.H.; RT "Non-conservative substitutions distinguish previously uncharacterized RT HLA-A molecules."; RL Tissue Antigens 57:95-102(2001). RN [12] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*26:15). RA Voorter C.E., Gervais T., van den Berg-Loonene E.M.; RT "New HLA-A alleles detected by sequence-based typing."; RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases. RN [13] RP NUCLEOTIDE SEQUENCE OF 26-298 (ALLELE A*26:07). RA Moine A.; RT "A new variant form of a HLA A*2607 allele."; RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases. RN [14] RP NUCLEOTIDE SEQUENCE [MRNA] OF 27-365 (ALLELE A*26:01). RX PubMed=2914713; DOI=10.1007/BF00395855; RA Cianetti L., Testa U., Scotto L., la Valle R., Simeone A., Boccoli G., RA Giannella G., Peschle C., Boncinelli E.; RT "Three new class I HLA alleles: structure of mRNAs and alternative RT mechanisms of processing."; RL Immunogenetics 29:80-91(1989). RN [15] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343; TYR-344; SER-345; RP SER-349; SER-352; SER-356 AND SER-359, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [16] RP VARIANT [LARGE SCALE ANALYSIS] 98-ASP--ASN-101 DELINS HIS-ARG-VAL-ASP, RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [17] RP VARIANT [LARGE SCALE ANALYSIS] 98-ASP--ASN-101 DELINS HIS-ARG-VAL-ASP, RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of A-26 are known: A*26:01, CC A*26:02, A*26:03, A*26:04 (A-10SA), A*26:05, A*26:07, A*26:08, CC A*26:12 and A*26:15. The sequence shown is that of A*26:01. CC {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; U03697; AAA03720.1; -; mRNA. DR EMBL; M98453; AAA35991.1; -; mRNA. DR EMBL; D14350; BAA03279.1; -; mRNA. DR EMBL; D14351; BAA03280.1; -; mRNA. DR EMBL; D14354; BAA03282.1; -; mRNA. DR EMBL; D16843; BAA04119.1; -; mRNA. DR EMBL; D32130; BAA06856.1; -; mRNA. DR EMBL; D32131; BAA06857.1; -; mRNA. DR EMBL; D32129; BAA06855.1; -; mRNA. DR EMBL; D50068; BAA08783.1; -; mRNA. DR EMBL; L48341; AAF25960.1; -; Genomic_DNA. DR EMBL; U52429; AAB08574.1; -; mRNA. DR EMBL; U45480; AAB38491.1; -; mRNA. DR EMBL; AH006114; AAC17438.1; -; Genomic_DNA. DR EMBL; AH007202; AAD02210.1; -; Genomic_DNA. DR EMBL; AJ291695; CAC27239.1; -; Genomic_DNA. DR EMBL; AJ291696; CAC27239.1; JOINED; Genomic_DNA. DR EMBL; AJ290394; CAC27416.2; -; mRNA. DR EMBL; M24095; AAA59655.1; -; mRNA. DR PIR; A37028; A37028. DR PIR; I38436; I38436. DR PIR; I84487; I84487. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR ProteinModelPortal; P30450; -. DR SMR; P30450; -. DR BioGrid; 109350; 90. DR iPTMnet; P30450; -. DR SwissPalm; P30450; -. DR PeptideAtlas; P30450; -. DR PRIDE; P30450; -. DR Ensembl; ENST00000383605; ENSP00000373100; ENSG00000206505. DR Ensembl; ENST00000549224; ENSP00000447990; ENSG00000206505. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P30450; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-26 alpha chain. FT /FTId=PRO_0000018820. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 60 60 F -> L (in allele A*26:15; FT dbSNP:rs3173429). {ECO:0000269|Ref.12}. FT /FTId=VAR_016341. FT VARIANT 86 87 RN -> GE (in allele A*26:07). FT {ECO:0000269|PubMed:8795143, FT ECO:0000269|Ref.13}. FT /FTId=VAR_016342. FT VARIANT 89 89 R -> G (in dbSNP:rs199474430). FT /FTId=VAR_050321. FT VARIANT 90 90 N -> K (in allele A*26:07; FT dbSNP:rs199474436). FT {ECO:0000269|PubMed:8795143, FT ECO:0000269|Ref.13}. FT /FTId=VAR_016343. FT VARIANT 94 94 H -> Q (in dbSNP:rs78306866). FT /FTId=VAR_050322. FT VARIANT 98 101 DRAN -> HRVD (in allele A*26:03). FT {ECO:0000244|PubMed:21269460, FT ECO:0000244|PubMed:25944712, FT ECO:0000269|PubMed:8026990, FT ECO:0000269|PubMed:8838351}. FT /FTId=VAR_004362. FT VARIANT 100 100 A -> E (in allele A*26:05; FT dbSNP:rs1071742). {ECO:0000269|Ref.6}. FT /FTId=VAR_016344. FT VARIANT 101 101 N -> D (in dbSNP:rs1136688). FT /FTId=VAR_050323. FT VARIANT 129 129 P -> S (in dbSNP:rs1136700). FT /FTId=VAR_050324. FT VARIANT 131 131 G -> W (in dbSNP:rs1136702). FT /FTId=VAR_050325. FT VARIANT 133 133 F -> L (in dbSNP:rs1059488). FT /FTId=VAR_050326. FT VARIANT 140 140 D -> N (in allele A*26:02; FT dbSNP:rs3173419). FT {ECO:0000269|PubMed:8026990, FT ECO:0000269|PubMed:8475492}. FT /FTId=VAR_004364. FT VARIANT 151 151 N -> K (in dbSNP:rs1059509). FT /FTId=VAR_050327. FT VARIANT 166 166 I -> T (in dbSNP:rs1059516). FT /FTId=VAR_050328. FT VARIANT 169 169 R -> H (in dbSNP:rs1059520). FT /FTId=VAR_050329. FT VARIANT 176 176 E -> V (in allele A*26:12; FT dbSNP:rs9256983). FT {ECO:0000269|PubMed:11098929, FT ECO:0000269|PubMed:11260503}. FT /FTId=VAR_016345. FT VARIANT 180 180 W -> Q (in allele A*26:08; requires 2 FT nucleotide substitutions). FT {ECO:0000269|PubMed:8896181, FT ECO:0000269|Ref.9}. FT /FTId=VAR_016346. FT VARIANT 180 180 W -> R (in dbSNP:rs9260155). FT /FTId=VAR_050330. FT VARIANT 185 185 E -> D (in dbSNP:rs1059542). FT /FTId=VAR_050331. FT VARIANT 187 187 R -> L (in allele A*26:04; FT dbSNP:rs3129017). FT {ECO:0000269|PubMed:8026990}. FT /FTId=VAR_004363. FT VARIANT 306 306 I -> V (in dbSNP:rs1136949). FT /FTId=VAR_014603. FT CONFLICT 153 153 D -> H (in Ref. 14; AAA59655). FT {ECO:0000305}. FT CONFLICT 160 160 A -> G (in Ref. 14; AAA59655). FT {ECO:0000305}. SQ SEQUENCE 365 AA; 41062 MW; 44B54DD363B46EDA CRC64; MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WETAHEAEQW RAYLEGRCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV // ID 1A29_HUMAN Reviewed; 365 AA. AC P30512; O02955; O19687; O98011; P30451; P79562; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1998, sequence version 2. DT 12-SEP-2018, entry version 151. DE RecName: Full=HLA class I histocompatibility antigen, A-29 alpha chain; DE AltName: Full=Aw-19; DE AltName: Full=MHC class I antigen A*29; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*29:01). RX PubMed=2461903; DOI=10.1007/BF02341610; RA Trapani J.A., Mizuno S., Kang S.H., Yang S.Y., Dupont B.; RT "Molecular mapping of a new public HLA class I epitope shared by all RT HLA-B and HLA-C antigens and defined by a monoclonal antibody."; RL Immunogenetics 29:25-32(1989). RN [2] RP SEQUENCE REVISION TO 345. RA Yang S.Y.; RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE A*29:01). RA Szmania S., Baxter-Lowe L.A.; RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*29:02). RX PubMed=1782566; RA Tabary T., Prochnicka-Chalufour A., Cornillet P., Lehoang P., RA Betuel H., Cohen H.M.; RT "HLA-A29 sub-types and 'Birdshot' choroido-retinopathy susceptibility: RT a possible 'resistance motif' in the HLA-A29.1 molecule."; RL C. R. Acad. Sci. III, Sci. Vie 313:599-605(1991). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ALLELE A*29:03). RX PubMed=9459513; DOI=10.1111/j.1399-0039.1998.tb02956.x; RA Prokupek B., Dunn P., Ross J., Jordan F., Holman R., Madrigal J.A., RA Little A.-M.; RT "HLA-A*2903 expresses an epitope shared with HLA-A*8001."; RL Tissue Antigens 51:115-118(1998). RN [6] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*29:04). RX PubMed=11260503; DOI=10.1034/j.1399-0039.2001.057002095.x; RA Hickman H.D., Cavett J.W., Ellexson-Turner M.E., Sparkman J.N., RA Bennett T.T., Turner S., Sidebottom D.A., Trachtenberg E.A., RA Confer D.L., Hildebrand W.H.; RT "Non-conservative substitutions distinguish previously uncharacterized RT HLA-A molecules."; RL Tissue Antigens 57:95-102(2001). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [8] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343; TYR-344; SER-345; RP SER-349; SER-352; SER-356 AND SER-359, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of A-29 are known: A*29:01 CC (A29.1), A*29:02 (A29.2), A*29:03 and A*29:04. The sequence shown CC is that of A*29:01. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M23739; AAB47873.1; -; mRNA. DR EMBL; U83415; AAB53373.1; -; mRNA. DR EMBL; X60108; CAA42702.1; -; mRNA. DR EMBL; AJ000661; CAA04209.1; -; mRNA. DR EMBL; Y09218; CAA70419.1; -; Genomic_DNA. DR EMBL; AH007203; AAD02224.1; -; Genomic_DNA. DR PIR; A45847; A45847. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR ProteinModelPortal; P30512; -. DR SMR; P30512; -. DR IntAct; P30512; 7. DR iPTMnet; P30512; -. DR SwissPalm; P30512; -. DR DMDM; 2851401; -. DR MaxQB; P30512; -. DR PeptideAtlas; P30512; -. DR PRIDE; P30512; -. DR Ensembl; ENST00000456012; ENSP00000408986; ENSG00000231834. DR UCSC; uc021zos.2; human. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P30512; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-29 alpha chain. FT /FTId=PRO_0000018821. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 90 90 N -> H (in allele A*29:04). FT {ECO:0000269|PubMed:11260503}. FT /FTId=VAR_016347. FT VARIANT 126 126 H -> D (in allele A*29:02, allele A*29:03 FT and allele A*29:04). FT {ECO:0000269|PubMed:11260503, FT ECO:0000269|PubMed:1782566, FT ECO:0000269|PubMed:9459513}. FT /FTId=VAR_004365. FT VARIANT 129 129 S -> P (in dbSNP:rs1136700). FT /FTId=VAR_056266. FT VARIANT 131 131 G -> W (in dbSNP:rs1136702). FT /FTId=VAR_056267. FT VARIANT 133 133 F -> L (in dbSNP:rs1059488). FT /FTId=VAR_056268. FT VARIANT 151 151 N -> K (in dbSNP:rs1059509). FT /FTId=VAR_056269. FT VARIANT 166 166 I -> T (in dbSNP:rs1059516). FT /FTId=VAR_056270. FT VARIANT 190 191 EW -> DG (in allele A*29:03). FT {ECO:0000269|PubMed:9459513}. FT /FTId=VAR_010372. SQ SEQUENCE 365 AA; 40863 MW; 56E4B9039B3C783C CRC64; MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDLQTRN VKAQSQTDRA NLGTLRGYYN QSEAGSHTIQ MMYGCHVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV // ID 1A30_HUMAN Reviewed; 365 AA. AC P16188; O19598; O62921; P30452; Q9UIP7; DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 2. DT 12-SEP-2018, entry version 155. DE RecName: Full=HLA class I histocompatibility antigen, A-30 alpha chain; DE AltName: Full=MHC class I antigen A*30; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE A*30:01). RX PubMed=2478623; RA Kato K., Trapani J.A., Allopenna J., Dupont B., Yang S.Y.; RT "Molecular analysis of the serologically defined HLA-Aw19 antigens. A RT genetically distinct family of HLA-A antigens comprising A29, A31, RT A32, and Aw33, but probably not A30."; RL J. Immunol. 143:3371-3378(1989). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*30:01). RX PubMed=7871528; DOI=10.1111/j.1399-0039.1994.tb02393.x; RA Olerup O., Daniels T.J., Baxter-Lowe L.; RT "Correct sequence of the A*3001 allele obtained by PCR-SSP typing and RT automated nucleotide sequencing."; RL Tissue Antigens 44:265-267(1994). RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE A*30:02). RX PubMed=1431115; RA Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J., RA Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., RA Martell R.W., du Toit E.D., Parham P.; RT "Distinctive HLA-A,B antigens of black populations formed by RT interallelic conversion."; RL J. Immunol. 149:3411-3415(1992). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-279 (ALLELE A*30:03). RX PubMed=8458735; DOI=10.1016/0198-8859(93)90004-K; RA Choo S.Y., Starling G.C., Anasetti C., Hansen J.A.; RT "Selection of an unrelated donor for marrow transplantation RT facilitated by the molecular characterization of a novel HLA-A RT allele."; RL Hum. Immunol. 36:20-26(1993). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*30:04). RX PubMed=8522453; DOI=10.1016/0198-8859(95)00046-7; RA Krausa P., Carcassi C., Orru S., Bodmer J.G., Browning M.J., Contu L.; RT "Defining the allelic variants of HLA-A30 in the Sardinian population RT using amplification refractory mutation system -- polymerase chain RT reaction."; RL Hum. Immunol. 44:35-42(1995). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 26-206 (ALLELE A*30:04). RX PubMed=8838350; DOI=10.1111/j.1399-0039.1995.tb03133.x; RA Lienert K., Russ G., Bennett G., Gao X., McCluskey J.; RT "HLA-A*3004: a new A30 allele identified in an Australian Caucasoid RT population."; RL Tissue Antigens 46:394-397(1995). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-205 (ALLELE A*30:04). RX PubMed=8560452; DOI=10.1111/j.1399-0039.1995.tb02500.x; RA Blasczyk R., Wehling J., Paessler M., Hahn U., Huhn D., Salama A.; RT "A novel HLA-A30 allele (A*3004) identified by single-strand RT conformation polymorphism analysis and confirmed by solid-phase RT sequencing."; RL Tissue Antigens 46:322-326(1995). RN [8] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*30:06). RX PubMed=11098929; DOI=10.1034/j.1399-0039.2000.560401.x; RA Ellis J.M., Mack S.J., Leke R.F.G., Quakyi I., Johnson A.H., RA Hurley C.K.; RT "Diversity is demonstrated in class I HLA-A and HLA-B alleles in RT Cameroon, Africa: description of HLA-A*03012, *2612, *3006 and HLA- RT B*1403, *4016, *4703."; RL Tissue Antigens 56:291-302(2000). RN [9] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*30:07). RX PubMed=10852390; DOI=10.1034/j.1399-0039.2000.550412.x; RA Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R., RA Ng J., Hartzman R.J., Hurley C.K.; RT "Seventeen more novel HLA-A locus alleles."; RL Tissue Antigens 55:369-373(2000). RN [10] RP NUCLEOTIDE SEQUENCE (ALLELE A*30:08). RX PubMed=11169261; DOI=10.1034/j.1399-0039.2001.057001070.x; RA Cox S.T., Mcwhinnie A.J., Koester R.P., Heine U., Holman R., RA Madrigal A.J., Little A.-M.; RT "Further diversity at HLA-A and -B loci identified in Afro-Caribbean RT potential bone marrow donors."; RL Tissue Antigens 57:70-72(2001). RN [11] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352; SER-356 AND RP SER-359, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [12] RP VARIANT [LARGE SCALE ANALYSIS] GLY-80, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [13] RP VARIANT [LARGE SCALE ANALYSIS] GLY-80, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of A-30 are known: A*30:01 CC (A30.3), A*30:02, A*30:03, A*30:04 (A30W7), A*30:06, A*30:07 and CC A*30:08. The sequence shown is that of A*30:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M30576; AAA59612.1; -; Genomic_DNA. DR EMBL; U07234; AAA70162.1; -; mRNA. DR EMBL; X61702; CAA43871.1; -; mRNA. DR EMBL; M93657; AAA58650.1; -; Genomic_DNA. DR EMBL; Z34921; CAA84401.1; -; Genomic_DNA. DR EMBL; AH005195; AAB53658.1; -; Genomic_DNA. DR EMBL; U24261; AAB50434.1; -; mRNA. DR EMBL; X83770; CAA58723.1; -; Genomic_DNA. DR EMBL; X83771; CAA58724.1; -; Genomic_DNA. DR EMBL; AH006045; AAC14191.1; -; Genomic_DNA. DR EMBL; AH006148; AAC18600.1; -; Genomic_DNA. DR EMBL; AJ249308; CAB57306.1; -; Genomic_DNA. DR EMBL; AJ249309; CAB57306.1; JOINED; Genomic_DNA. DR EMBL; AJ249310; CAB57306.1; JOINED; Genomic_DNA. DR EMBL; AJ249311; CAB57306.1; JOINED; Genomic_DNA. DR EMBL; AJ249312; CAB57306.1; JOINED; Genomic_DNA. DR EMBL; AJ249313; CAB57306.1; JOINED; Genomic_DNA. DR EMBL; AJ249314; CAB57306.1; JOINED; Genomic_DNA. DR EMBL; AJ249315; CAB57306.1; JOINED; Genomic_DNA. DR PIR; I38519; I38519. DR PIR; I54307; I54307. DR PIR; I56039; I56039. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR ProteinModelPortal; P16188; -. DR SMR; P16188; -. DR IntAct; P16188; 1. DR iPTMnet; P16188; -. DR SwissPalm; P16188; -. DR DMDM; 1345596; -. DR EPD; P16188; -. DR MaxQB; P16188; -. DR PeptideAtlas; P16188; -. DR PRIDE; P16188; -. DR Ensembl; ENST00000376809; ENSP00000366005; ENSG00000206503. DR Ensembl; ENST00000396634; ENSP00000379873; ENSG00000206503. DR UCSC; uc003nol.3; human. DR DisGeNET; 3105; -. DR EuPathDB; HostDB:ENSG00000206503.11; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR HPA; CAB078470; -. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P16188; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR TreeFam; TF336617; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000206503; Expressed in 239 organ(s), highest expression level in mononuclear cell. DR CleanEx; HS_HLA-A; -. DR ExpressionAtlas; P16188; baseline and differential. DR Genevisible; P16188; HS. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0046977; F:TAP binding; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-30 alpha chain. FT /FTId=PRO_0000018822. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 21 21 H -> Q (in allele A*30:02, allele A*30:04 FT and allele A*30:08). FT /FTId=VAR_004366. FT VARIANT 33 33 S -> Y (in allele A*30:08). FT /FTId=VAR_010284. FT VARIANT 55 55 T -> A (in allele A*30:06). FT /FTId=VAR_016653. FT VARIANT 80 80 R -> G (in allele A*30:03). FT {ECO:0000244|PubMed:21269460, FT ECO:0000244|PubMed:25944712}. FT /FTId=VAR_004367. FT VARIANT 86 86 Q -> E (in allele A*30:07). FT /FTId=VAR_016738. FT VARIANT 89 90 RN -> GK (in allele A*30:07). FT /FTId=VAR_016739. FT VARIANT 89 89 R -> G (in dbSNP:rs199474430). FT /FTId=VAR_056271. FT VARIANT 94 94 Q -> H (in allele A*30:02, allele FT A*30:03, allele A*30:04, allele A*30:06 FT and allele A*30:07; dbSNP:rs78306866). FT /FTId=VAR_004368. FT VARIANT 100 101 VD -> EN (in allele A*30:02, allele FT A*30:03, allele A*30:04, allele A*30:06 FT and allele A*30:07). FT /FTId=VAR_004369. FT VARIANT 101 101 D -> N (in dbSNP:rs1136688). FT /FTId=VAR_056272. FT VARIANT 121 121 I -> M (in dbSNP:rs1136695). FT /FTId=VAR_056273. FT VARIANT 129 129 S -> P (in dbSNP:rs1136700). FT /FTId=VAR_056274. FT VARIANT 131 131 G -> W (in dbSNP:rs1136702). FT /FTId=VAR_056275. FT VARIANT 133 133 F -> L (in dbSNP:rs1059488). FT /FTId=VAR_056276. FT VARIANT 151 151 N -> K (in dbSNP:rs1059509). FT /FTId=VAR_056277. FT VARIANT 166 166 I -> T (in dbSNP:rs1059516). FT /FTId=VAR_056278. FT VARIANT 175 176 RW -> HV (in allele A*30:04 and allele FT A*30:06). FT /FTId=VAR_004370. FT VARIANT 176 176 W -> R (in allele A*30:02, allele A*30:03 FT and allele A*30:07). FT /FTId=VAR_004371. FT VARIANT 180 180 L -> W (in allele A*30:04 and allele FT A*30:06). FT /FTId=VAR_004372. FT VARIANT 205 205 R -> H (in dbSNP:rs17185861). FT /FTId=VAR_056279. FT CONFLICT 33 33 S -> F (in Ref. 1; AAA59612). FT {ECO:0000305}. SQ SEQUENCE 365 AA; 40905 MW; 521166D95FB1DC28 CRC64; MAVMAPRTLL LLLSGALALT HTWAGSHSMR YFSTSVSRPG SGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQER PEYWDQETRN VKAQSQTDRV DLGTLRGYYN QSEAGSHTIQ IMYGCDVGSD GRFLRGYEQH AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARWAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL TACKV // ID 1A31_HUMAN Reviewed; 365 AA. AC P16189; O62924; O98009; O98137; Q8MHM1; Q9TPQ3; Q9TQ24; Q9UQU6; AC Q9UQU7; DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 2. DT 12-SEP-2018, entry version 151. DE RecName: Full=HLA class I histocompatibility antigen, A-31 alpha chain; DE AltName: Full=MHC class I antigen A*31; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE A*31:01). RX PubMed=2478623; RA Kato K., Trapani J.A., Allopenna J., Dupont B., Yang S.Y.; RT "Molecular analysis of the serologically defined HLA-Aw19 antigens. A RT genetically distinct family of HLA-A antigens comprising A29, A31, RT A32, and Aw33, but probably not A30."; RL J. Immunol. 143:3371-3378(1989). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE A*31:01). RX PubMed=1317015; DOI=10.1038/357326a0; RA Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J., RA Williams R.C., Luz R., Petzl-Erler M.L., Parham P.; RT "Unusual HLA-B alleles in two tribes of Brazilian Indians."; RL Nature 357:326-329(1992). RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE A*31:01). RX PubMed=8795145; DOI=10.1111/j.1399-0039.1996.tb02580.x; RA Arnett K.L., Adams E.J., Parham P.; RT "On the sequence of A*3101."; RL Tissue Antigens 47:428-430(1996). RN [4] RP NUCLEOTIDE SEQUENCE OF 9-365 (ALLELE A*31:01). RX PubMed=1589035; DOI=10.1038/357329a0; RA Watkins D.I., McAdam S.N., Liu X., Stang C.R., Milford E.L., RA Levine C.G., Garber T.L., Dogon A.L., Lord C.I., Ghim S.H., RA Troup G.M., Hughes A.L., Letvin N.L.; RT "New recombinant HLA-B alleles in a tribe of South American RT Amerindians indicate rapid evolution of MHC class I loci."; RL Nature 357:329-333(1992). RN [5] RP NUCLEOTIDE SEQUENCE (ALLELE A*31:04). RA Bettinotti M.P., Dhillon G., Hackett J., Simonis T.B., Marincola F.M.; RT "A new HLA-A*31 allele."; RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*31:03). RA Bunce M., Dunn P., Ross J.; RT "Characterization of two new HLA-A alleles identified by PCR-SSP."; RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*31:04). RA Mitsuishi Y.; RT "New HLA-A31 allele identified in African American population."; RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*31:02). RA Dunn P.P.; RT "Characterization of an HLA-A*31 variant."; RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*31:05). RA Juji T., Akesaka T., Kashiwase K., Ishikawa Y.; RT "HLA-A31012V1."; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*31:02). RX PubMed=11260503; DOI=10.1034/j.1399-0039.2001.057002095.x; RA Hickman H.D., Cavett J.W., Ellexson-Turner M.E., Sparkman J.N., RA Bennett T.T., Turner S., Sidebottom D.A., Trachtenberg E.A., RA Confer D.L., Hildebrand W.H.; RT "Non-conservative substitutions distinguish previously uncharacterized RT HLA-A molecules."; RL Tissue Antigens 57:95-102(2001). RN [11] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*31:06). RC TISSUE=Blood; RA Anholts J.D.H.; RT "Four new HLA alleles found, and confirmation of DRB1*0322, DRB1*1433 RT and A*3106."; RL Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases. RN [12] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [13] RP ASSOCIATION OF ALLELE A*31:01 WITH CARBAMAZEPINE-INDUCED RP HYPERSENSITIVITY REACTIONS. RX PubMed=21428769; DOI=10.1056/NEJMoa1013297; RA McCormack M., Alfirevic A., Bourgeois S., Farrell J.J., RA Kasperaviciute D., Carrington M., Sills G.J., Marson T., Jia X., RA de Bakker P.I., Chinthapalli K., Molokhia M., Johnson M.R., RA O'Connor G.D., Chaila E., Alhusaini S., Shianna K.V., Radtke R.A., RA Heinzen E.L., Walley N., Pandolfo M., Pichler W., Park B.K., RA Depondt C., Sisodiya S.M., Goldstein D.B., Deloukas P., Delanty N., RA Cavalleri G.L., Pirmohamed M.; RT "HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in RT Europeans."; RL N. Engl. J. Med. 364:1134-1143(2011). RN [14] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343; TYR-344; SER-345; RP SER-349; SER-352; SER-356 AND SER-359, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [15] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of A-31 are known: A*31:01, CC A*31:02, A*31:03, A*31:04, A*31:05 (A3101v1) and A*31:06. The CC sequence shown is that of A*31:01. Allele A*31:01 is associated CC with carbamazepine-induced hypersensitivity reactions among CC subjects of Northern European ancestry [MIM:608579]. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M30578; AAA59613.1; -; Genomic_DNA. DR EMBL; M84375; AAA59599.1; -; mRNA. DR EMBL; L78918; AAB05976.1; -; Genomic_DNA. DR EMBL; AF148863; AAD39981.1; -; Genomic_DNA. DR EMBL; AH006155; AAC18859.1; -; Genomic_DNA. DR EMBL; AH007022; AAC79721.1; -; Genomic_DNA. DR EMBL; AJ239045; CAB43109.1; -; Genomic_DNA. DR EMBL; AJ239046; CAB43110.1; -; Genomic_DNA. DR EMBL; AB032597; BAA84645.1; -; Genomic_DNA. DR EMBL; AH007200; AAD02207.1; -; Genomic_DNA. DR EMBL; AJ506789; CAD44950.1; -; Genomic_DNA. DR EMBL; AJ506790; CAD44950.1; JOINED; Genomic_DNA. DR PIR; I72170; I72170. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR ProteinModelPortal; P16189; -. DR SMR; P16189; -. DR IntAct; P16189; 1. DR iPTMnet; P16189; -. DR SwissPalm; P16189; -. DR DMDM; 231367; -. DR EPD; P16189; -. DR MaxQB; P16189; -. DR PeptideAtlas; P16189; -. DR PRIDE; P16189; -. DR Ensembl; ENST00000456012; ENSP00000408986; ENSG00000231834. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR MIM; 608579; phenotype. DR neXtProt; NX_P16189; -. DR HOVERGEN; HBG016709; -. DR PhylomeDB; P16189; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0046977; F:TAP binding; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-31 alpha chain. FT /FTId=PRO_0000018823. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 90 90 N -> K (in allele A*31:02). FT /FTId=VAR_016348. FT VARIANT 114 114 A -> D (in allele A*31:03). FT /FTId=VAR_016349. FT VARIANT 121 121 M -> I (in allele A*31:03 and allele FT A*31:04). FT /FTId=VAR_010373. FT VARIANT 138 138 Q -> R (in allele A*31:03, allele A*31:04 FT and allele A*31:06). FT /FTId=VAR_010374. FT VARIANT 151 151 N -> K (in dbSNP:rs1059509). FT /FTId=VAR_056280. FT VARIANT 166 166 I -> T (in dbSNP:rs1059516). FT /FTId=VAR_056281. FT VARIANT 190 191 EW -> DG (in allele A*31:05). FT /FTId=VAR_016350. FT VARIANT 205 205 R -> H (in dbSNP:rs17185861). FT /FTId=VAR_056282. SQ SEQUENCE 365 AA; 41004 MW; 4E760C821A3C553B CRC64; MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQER PEYWDQETRN VKAHSQIDRV DLGTLRGYYN QSEAGSHTIQ MMYGCDVGSD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDPPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV // ID 1A32_HUMAN Reviewed; 365 AA. AC P10314; O77937; Q29838; Q8MHN9; Q9MYE9; Q9MYG5; Q9TQF5; Q9TQF9; DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1995, sequence version 2. DT 12-SEP-2018, entry version 155. DE RecName: Full=HLA class I histocompatibility antigen, A-32 alpha chain; DE AltName: Full=MHC class I antigen A*32; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE A*32:01). RA Domena J.D.; RL Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE OF 25-298 (ALLELE A*32:01). RX PubMed=2431040; RA Wan A.M., Ennis P., Parham P., Holmes N.; RT "The primary structure of HLA-A32 suggests a region involved in RT formation of the Bw4/Bw6 epitopes."; RL J. Immunol. 137:3671-3674(1986). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*32:02). RC TISSUE=Blood; RX PubMed=8881042; DOI=10.1007/s002510050171; RA Zino E., Severini G.M., Mazzi B., Bordignon C., Benazzi E., RA Fleischhauer K.; RT "Sequencing of a new HLA-A*32 subtype (A*3202)."; RL Immunogenetics 45:76-77(1996). RN [4] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*32:03 AND A*32:04). RX PubMed=10852390; DOI=10.1034/j.1399-0039.2000.550412.x; RA Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R., RA Ng J., Hartzman R.J., Hurley C.K.; RT "Seventeen more novel HLA-A locus alleles."; RL Tissue Antigens 55:369-373(2000). RN [5] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*32:03). RA Kanaan C., Hepner J., Thornton A.; RT "Confirmatory exon 2 and 3 sequence for HLA-A*3203."; RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE (ALLELE A*32:05). RA Bettinotti M.P., Hadzikadic L., Adams S., Marincola F.M.; RT "A new HLA A-32 allele."; RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*32:06). RA Jones P.F., Hurley C.K.; RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases. RN [8] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343; TYR-344; SER-345; RP SER-349; SER-352; SER-356 AND SER-359, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [9] RP VARIANT [LARGE SCALE ANALYSIS] ASP-185, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [10] RP VARIANT [LARGE SCALE ANALYSIS] ASP-185, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of A-32 are known: A*32:01, CC A*32:02, A*32:03, A*32:04, A*32:05 and A*32:06. The sequence shown CC is that of A*32:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; U03907; AAA03605.1; -; mRNA. DR EMBL; X97120; CAA65786.1; -; mRNA. DR EMBL; AH006303; AAC26020.1; -; Genomic_DNA. DR EMBL; AH007756; AAD33738.1; -; Genomic_DNA. DR EMBL; AH007758; AAD33849.1; -; Genomic_DNA. DR EMBL; AH011735; AAM78538.1; -; Genomic_DNA. DR EMBL; AF217560; AAF28733.1; -; mRNA. DR EMBL; AH009113; AAF29554.1; -; Genomic_DNA. DR PIR; A26088; HLHU32. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR ProteinModelPortal; P10314; -. DR SMR; P10314; -. DR iPTMnet; P10314; -. DR SwissPalm; P10314; -. DR DMDM; 1168210; -. DR PeptideAtlas; P10314; -. DR PRIDE; P10314; -. DR Ensembl; ENST00000454091; ENSP00000410645; ENSG00000223980. DR Ensembl; ENST00000552493; ENSP00000448992; ENSG00000223980. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P10314; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR PhylomeDB; P10314; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0046977; F:TAP binding; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0042270; P:protection from natural killer cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-32 alpha chain. FT /FTId=PRO_0000018824. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 89 90 RN -> GK (in allele A*32:05). FT /FTId=VAR_016656. FT VARIANT 89 89 R -> G (in dbSNP:rs199474430). FT /FTId=VAR_056283. FT VARIANT 101 101 S -> N (in allele A*32:03; FT dbSNP:rs2231004). FT /FTId=VAR_016657. FT VARIANT 121 121 M -> I (in allele A*32:04; FT dbSNP:rs1136695). FT /FTId=VAR_016831. FT VARIANT 129 129 P -> S (in allele A*32:04; FT dbSNP:rs1136700). FT /FTId=VAR_016832. FT VARIANT 133 133 L -> F (in allele A*32:04; FT dbSNP:rs1059488). FT /FTId=VAR_016833. FT VARIANT 138 138 Q -> R (in allele A*32:04; FT dbSNP:rs3173420). FT /FTId=VAR_016834. FT VARIANT 151 151 N -> K (in dbSNP:rs1059509). FT /FTId=VAR_056284. FT VARIANT 166 166 I -> T (in dbSNP:rs1059516). FT /FTId=VAR_056285. FT VARIANT 168 168 Q -> K (in allele A*32:04; FT dbSNP:rs1059517). FT /FTId=VAR_016835. FT VARIANT 175 175 R -> H (in allele A*32:02, allele A*32:04 FT and allele A*32:06; dbSNP:rs1059536). FT /FTId=VAR_004373. FT VARIANT 176 176 V -> E (in allele A*32:04; FT dbSNP:rs9256983). FT /FTId=VAR_016836. FT VARIANT 180 180 L -> Q (in allele A*32:02). FT /FTId=VAR_004374. FT VARIANT 185 185 E -> D (in allele A*32:04; FT dbSNP:rs1059542). FT {ECO:0000244|PubMed:21269460, FT ECO:0000244|PubMed:25944712}. FT /FTId=VAR_016837. SQ SEQUENCE 365 AA; 41048 MW; BF7AF225329E0319 CRC64; MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAHSQTDRE SLRIALRYYN QSEAGSHTIQ MMYGCDVGPD GRLLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA MFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV // ID 1A33_HUMAN Reviewed; 365 AA. AC P16190; O02939; O02954; DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1998, sequence version 3. DT 12-SEP-2018, entry version 146. DE RecName: Full=HLA class I histocompatibility antigen, A-33 alpha chain; DE AltName: Full=Aw-19; DE AltName: Full=Aw-33; DE AltName: Full=MHC class I antigen A*33; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE A*33:01). RX PubMed=2478623; RA Kato K., Trapani J.A., Allopenna J., Dupont B., Yang S.Y.; RT "Molecular analysis of the serologically defined HLA-Aw19 antigens. A RT genetically distinct family of HLA-A antigens comprising A29, A31, RT A32, and Aw33, but probably not A30."; RL J. Immunol. 143:3371-3378(1989). RN [2] RP SEQUENCE REVISION TO 178-179; 210 AND 345. RA Yang S.Y.; RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE A*33:01). RA Szmania S., Baxter-Lowe L.A.; RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*33:02). RX PubMed=8362415; DOI=10.1111/j.1399-0039.1993.tb02006.x; RA Kato N., Kikuchi A., Kano K., Egawa K., Takiguchi M.; RT "Molecular analysis of a novel HLA-A33 subtype associated with HLA- RT B44."; RL Tissue Antigens 41:211-213(1993). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*33:03). RX PubMed=7725315; DOI=10.1111/j.1399-0039.1995.tb02418.x; RA Balas A., Garcia-Sanchez F., Vicario J.L.; RT "Molecular characterization of a novel HLA-A33 allele (A*3303)."; RL Tissue Antigens 45:73-76(1995). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-99 AND 122-205 (ALLELES RP A*33:01 AND A*33:03). RX PubMed=7652743; DOI=10.1111/j.1399-0039.1995.tb02465.x; RA Blasczyk R., Wehling J., Hahn U., Schwella N., Huhn D., Salama A.; RT "Identification of a novel HLA-A33 subtype (A*3303) and correction of RT the A*3301 sequence."; RL Tissue Antigens 45:348-352(1995). RN [7] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*33:01 AND A*33:03). RA Gao X., Jakobsen I., Serjeantson S.W.; RL Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases. RN [8] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, VARIANT [LARGE RP SCALE ANALYSIS] VAL-358, AND IDENTIFICATION BY MASS SPECTROMETRY RP [LARGE SCALE ANALYSIS]. RC TISSUE=Platelet; RX PubMed=18088087; DOI=10.1021/pr0704130; RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., RA Schuetz C., Walter U., Gambaryan S., Sickmann A.; RT "Phosphoproteome of resting human platelets."; RL J. Proteome Res. 7:526-534(2008). RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356 AND SER-359, VARIANT RP [LARGE SCALE ANALYSIS] VAL-358, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [11] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343; TYR-344; SER-345; RP SER-349; SER-350; SER-352; SER-356 AND SER-359, VARIANT [LARGE SCALE RP ANALYSIS] VAL-358, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE RP SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [12] RP VARIANT [LARGE SCALE ANALYSIS] VAL-358, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., RA Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in RT a refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [13] RP VARIANT [LARGE SCALE ANALYSIS] VAL-358, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of A-33 are known: A*33:01 CC (Aw-33.1), A*33:02 and A*33:03. The sequence shown is that of CC A*33:01. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M30580; AAB47870.1; -; Genomic_DNA. DR EMBL; U83416; AAB53374.1; -; mRNA. DR EMBL; L06440; AAA71914.1; -; mRNA. DR EMBL; U09740; AAA79865.1; -; mRNA. DR EMBL; X83004; CAA58125.1; -; Genomic_DNA. DR EMBL; X83005; CAA58126.1; -; Genomic_DNA. DR EMBL; X83002; CAA58123.1; -; Genomic_DNA. DR EMBL; X83003; CAA58124.1; -; Genomic_DNA. DR EMBL; AH005379; AAB60652.1; -; Genomic_DNA. DR EMBL; AH005380; AAB60653.1; -; Genomic_DNA. DR PIR; I38610; I38610. DR PIR; S51099; S51099. DR PIR; S51100; S51100. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR ProteinModelPortal; P16190; -. DR SMR; P16190; -. DR iPTMnet; P16190; -. DR SwissPalm; P16190; -. DR DMDM; 2851527; -. DR EPD; P16190; -. DR MaxQB; P16190; -. DR PeptideAtlas; P16190; -. DR PRIDE; P16190; -. DR Ensembl; ENST00000456012; ENSP00000408986; ENSG00000231834. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P16190; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-33 alpha chain. FT /FTId=PRO_0000018825. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:18088087, FT ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 41 41 R -> S (in allele A*33:02). FT {ECO:0000269|PubMed:8362415}. FT /FTId=VAR_004375. FT VARIANT 151 151 N -> K (in dbSNP:rs1059509). FT /FTId=VAR_056286. FT VARIANT 166 166 I -> T (in dbSNP:rs1059516). FT /FTId=VAR_056287. FT VARIANT 195 195 H -> Y (in allele A*33:02 and allele FT A*33:03). {ECO:0000269|PubMed:7652743, FT ECO:0000269|PubMed:7725315, FT ECO:0000269|PubMed:8362415, FT ECO:0000269|Ref.7}. FT /FTId=VAR_004376. FT VARIANT 217 218 AV -> PI (in allele A*33:02). FT {ECO:0000269|PubMed:8362415}. FT /FTId=VAR_004377. FT VARIANT 358 358 M -> V (in allele A*33:02). FT {ECO:0000244|PubMed:18088087, FT ECO:0000244|PubMed:19413330, FT ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569, FT ECO:0000244|PubMed:25944712, FT ECO:0000269|PubMed:8362415}. FT /FTId=VAR_004378. FT CONFLICT 210 210 K -> R (in Ref. 3; AAB53374). FT {ECO:0000305}. SQ SEQUENCE 365 AA; 40892 MW; 060AE508EADEB328 CRC64; MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAHSQIDRV DLGTLRGYYN QSEAGSHTIQ MMYGCDVGSD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRHLENGK ETLQRTDPPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV // ID 1A34_HUMAN Reviewed; 365 AA. AC P30453; P30454; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 144. DE RecName: Full=HLA class I histocompatibility antigen, A-34 alpha chain; DE AltName: Full=Aw-34; DE AltName: Full=HLA class I histocompatibility antigen, A-10 alpha chain; DE AltName: Full=MHC class I antigen A*34; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES A*34:01 AND A*34:02). RX PubMed=1431115; RA Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J., RA Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., RA Martell R.W., du Toit E.D., Parham P.; RT "Distinctive HLA-A,B antigens of black populations formed by RT interallelic conversion."; RL J. Immunol. 149:3411-3415(1992). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES A*34:01 AND A*34:02). RX PubMed=8475492; DOI=10.1111/j.1399-0039.1993.tb01982.x; RA Madrigal J.A., Hildebrand W.H., Belich M.P., Benjamin R.J., RA Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., RA du Toit E.D., Parham P.; RT "Structural diversity in the HLA-A10 family of alleles: correlations RT with serology."; RL Tissue Antigens 41:72-80(1993). RN [3] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [4] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343; TYR-344; SER-345; RP SER-349; SER-352; SER-356 AND SER-359, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of A-34 are known: A*34:01 CC (Aw-34.1) and A*34:02 (Aw-34.2). The sequence shown is that of CC A*34:01. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X61704; CAA43873.1; -; mRNA. DR EMBL; X61705; CAA43874.1; -; mRNA. DR PIR; I37477; I37477. DR PIR; I37483; I37483. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR ProteinModelPortal; P30453; -. DR SMR; P30453; -. DR iPTMnet; P30453; -. DR SwissPalm; P30453; -. DR DMDM; 231368; -. DR EPD; P30453; -. DR MaxQB; P30453; -. DR PeptideAtlas; P30453; -. DR PRIDE; P30453; -. DR Ensembl; ENST00000383605; ENSP00000373100; ENSG00000206505. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P30453; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-6798695; Neutrophil degranulation. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030667; C:secretory granule membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-34 alpha chain. FT /FTId=PRO_0000018826. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 3 3 I -> V (in allele A*34:02). FT {ECO:0000269|PubMed:1431115, FT ECO:0000269|PubMed:8475492}. FT /FTId=VAR_004379. FT VARIANT 90 90 K -> N (in allele A*34:02). FT {ECO:0000269|PubMed:1431115, FT ECO:0000269|PubMed:8475492}. FT /FTId=VAR_004380. FT VARIANT 101 101 D -> N (in dbSNP:rs1136688). FT /FTId=VAR_056288. FT VARIANT 121 121 R -> I (in allele A*34:02). FT {ECO:0000269|PubMed:1431115, FT ECO:0000269|PubMed:8475492}. FT /FTId=VAR_004381. FT VARIANT 129 129 P -> S (in allele A*34:02). FT {ECO:0000269|PubMed:1431115, FT ECO:0000269|PubMed:8475492}. FT /FTId=VAR_004382. FT VARIANT 138 138 Q -> R (in allele A*34:02). FT {ECO:0000269|PubMed:1431115, FT ECO:0000269|PubMed:8475492}. FT /FTId=VAR_004383. FT VARIANT 151 151 N -> K (in dbSNP:rs1059509). FT /FTId=VAR_056289. FT VARIANT 166 166 I -> T (in dbSNP:rs1059516). FT /FTId=VAR_056290. FT VARIANT 180 180 W -> L (in allele A*34:02). FT {ECO:0000269|PubMed:1431115, FT ECO:0000269|PubMed:8475492}. FT /FTId=VAR_004384. FT VARIANT 312 312 L -> I (in allele A*34:02). FT {ECO:0000269|PubMed:1431115, FT ECO:0000269|PubMed:8475492}. FT /FTId=VAR_004385. SQ SEQUENCE 365 AA; 41055 MW; 063BF63E6E6E01F6 CRC64; MAIMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDRNTRK VKAQSQTDRV DLGTLRGYYN QSEDGSHTIQ RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WETAHEAEQW RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG ILAGLVLFGA VIAGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV // ID 1A36_HUMAN Reviewed; 365 AA. AC P30455; Q9MY89; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 148. DE RecName: Full=HLA class I histocompatibility antigen, A-36 alpha chain; DE AltName: Full=Aw-36; DE AltName: Full=MHC class I antigen A*36; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*36:01). RX PubMed=1431115; RA Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J., RA Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., RA Martell R.W., du Toit E.D., Parham P.; RT "Distinctive HLA-A,B antigens of black populations formed by RT interallelic conversion."; RL J. Immunol. 149:3411-3415(1992). RN [2] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*36:02). RA Rizzuto G.A., Hurley C.K.; RT "Novel HLA-A Allele."; RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases. RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352; SER-356 AND RP SER-359, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] RP VARIANT [LARGE SCALE ANALYSIS] THR-166, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of A-36 are known: A*36:01 and CC A*36:02. The sequence shown is that of A*36:01. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X61700; CAA43869.1; -; mRNA. DR EMBL; AH009486; AAF78082.1; -; Genomic_DNA. DR PIR; I37478; I37478. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR ProteinModelPortal; P30455; -. DR SMR; P30455; -. DR iPTMnet; P30455; -. DR SwissPalm; P30455; -. DR DMDM; 231370; -. DR EPD; P30455; -. DR MaxQB; P30455; -. DR PeptideAtlas; P30455; -. DR PRIDE; P30455; -. DR Ensembl; ENST00000431930; ENSP00000406366; ENSG00000229215. DR Ensembl; ENST00000443552; ENSP00000404678; ENSG00000224320. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P30455; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-36 alpha chain. FT /FTId=PRO_0000018827. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 89 89 R -> G (in dbSNP:rs199474430). FT /FTId=VAR_056291. FT VARIANT 131 131 G -> W (in dbSNP:rs1136702). FT /FTId=VAR_056292. FT VARIANT 133 133 F -> L (in dbSNP:rs1059488). FT /FTId=VAR_056293. FT VARIANT 151 151 N -> K (in dbSNP:rs1059509). FT /FTId=VAR_056294. FT VARIANT 166 166 I -> T (in dbSNP:rs1059516). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056295. FT VARIANT 169 169 R -> H (in dbSNP:rs1059520). FT /FTId=VAR_056296. FT VARIANT 182 182 V -> A (in allele A*36:02). FT {ECO:0000269|Ref.2}. FT /FTId=VAR_016610. FT VARIANT 185 185 E -> D (in allele A*36:02). FT {ECO:0000269|Ref.2}. FT /FTId=VAR_016611. FT VARIANT 205 205 R -> H (in dbSNP:rs17185861). FT /FTId=VAR_056297. SQ SEQUENCE 365 AA; 40934 MW; BA00A0085989CD3E CRC64; MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQKME PRAPWIEQEG PEYWDQETRN MKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAVHAAEQR RVYLEGTCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL TACKV // ID 1A43_HUMAN Reviewed; 365 AA. AC P30456; O19509; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 138. DE RecName: Full=HLA class I histocompatibility antigen, A-43 alpha chain; DE AltName: Full=Aw-43; DE AltName: Full=MHC class I antigen A*43; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE A*43:01). RX PubMed=1431115; RA Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J., RA Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., RA Martell R.W., du Toit E.D., Parham P.; RT "Distinctive HLA-A,B antigens of black populations formed by RT interallelic conversion."; RL J. Immunol. 149:3411-3415(1992). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE A*43:01). RX PubMed=8475492; DOI=10.1111/j.1399-0039.1993.tb01982.x; RA Madrigal J.A., Hildebrand W.H., Belich M.P., Benjamin R.J., RA Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., RA du Toit E.D., Parham P.; RT "Structural diversity in the HLA-A10 family of alleles: correlations RT with serology."; RL Tissue Antigens 41:72-80(1993). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE A*43:01). RX PubMed=10519370; DOI=10.1034/j.1399-0039.1999.540314.x; RA Bei M., Ng J., Slack R., Ellis J., Hartzman R.J., Hurley C.K.; RT "The relative frequencies of HLA-A*10 alleles in five major United RT States ethnic populations."; RL Tissue Antigens 54:295-299(1999). RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343; TYR-344; SER-345; RP SER-349; SER-352; SER-356 AND SER-359, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The only allele of A-43 known is A*43:01 which is CC shown here. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X61703; CAA43872.1; -; mRNA. DR EMBL; AH005526; AAB65408.1; -; Genomic_DNA. DR PIR; I72171; I72171. DR PIR; S16769; S16769. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR ProteinModelPortal; P30456; -. DR SMR; P30456; -. DR iPTMnet; P30456; -. DR SwissPalm; P30456; -. DR DMDM; 231371; -. DR EPD; P30456; -. DR PeptideAtlas; P30456; -. DR PRIDE; P30456; -. DR Ensembl; ENST00000383605; ENSP00000373100; ENSG00000206505. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P30456; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-43 alpha chain. FT /FTId=PRO_0000018828. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 151 151 N -> K (in dbSNP:rs1059509). FT /FTId=VAR_056298. FT VARIANT 166 166 I -> T (in dbSNP:rs1059516). FT /FTId=VAR_056299. SQ SEQUENCE 365 AA; 41033 MW; 213FC69745FB4B0B CRC64; MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDLQTRN VKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WETAHEAEQW RAYLEGRCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV // ID 1A66_HUMAN Reviewed; 365 AA. AC P30457; P30458; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 152. DE RecName: Full=HLA class I histocompatibility antigen, A-66 alpha chain; DE AltName: Full=Aw-66; DE AltName: Full=HLA class I histocompatibility antigen, A-10 alpha chain; DE AltName: Full=MHC class I antigen A*66; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES A*66:01 AND A*66:02). RX PubMed=1940790; DOI=10.1084/jem.174.5.1085; RA Madrigal J., Belich M.P., Benjamin R.J., Little A.-M., RA Hildebrand W.H., Mann D.L., Parham P.; RT "Molecular definition of a polymorphic antigen (LA45) of free HLA-A RT and -B heavy chains found on the surfaces of activated B and T RT cells."; RL J. Exp. Med. 174:1085-1095(1991). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*66:02). RX PubMed=2139695; DOI=10.1084/jem.171.5.1431; RA Schnabl E., Stockinger H., Majdic O., Gaugitsch H., Lindley I.J.D., RA Maurer D., Hajek-Rosenmayr A., Knapp W.; RT "Activated human T lymphocytes express MHC class I heavy chains not RT associated with beta 2-microglobulin."; RL J. Exp. Med. 171:1431-1442(1990). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-322 (ALLELE A*66:01). RA Hurley C.K., Bei M.; RL Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases. RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343; TYR-344; SER-345; RP SER-349; SER-352; SER-356 AND SER-359, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of A-66 are known: A*66:01 and CC A*66:02 (Aw67). The sequence shown is that of A*66:01. CC {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X61711; CAA43880.1; -; mRNA. DR EMBL; X61712; CAA43881.1; -; mRNA. DR EMBL; X51745; CAA36034.1; -; mRNA. DR EMBL; U17571; AAA56781.1; -; mRNA. DR PIR; JL0135; JL0135. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR ProteinModelPortal; P30457; -. DR SMR; P30457; -. DR iPTMnet; P30457; -. DR SwissPalm; P30457; -. DR DMDM; 231372; -. DR MaxQB; P30457; -. DR PeptideAtlas; P30457; -. DR PRIDE; P30457; -. DR Ensembl; ENST00000383605; ENSP00000373100; ENSG00000206505. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P30457; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-66 alpha chain. FT /FTId=PRO_0000018829. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 28 28 S -> W (in allele A*66:02). FT {ECO:0000269|PubMed:1940790, FT ECO:0000269|PubMed:2139695}. FT /FTId=VAR_004386. FT VARIANT 89 89 R -> G (in dbSNP:rs199474430). FT /FTId=VAR_056300. FT VARIANT 101 101 D -> N (in dbSNP:rs1136688). FT /FTId=VAR_056301. FT VARIANT 114 114 D -> A (in allele A*66:02). FT {ECO:0000269|PubMed:1940790, FT ECO:0000269|PubMed:2139695}. FT /FTId=VAR_004387. FT VARIANT 151 151 N -> K (in dbSNP:rs1059509). FT /FTId=VAR_056302. FT VARIANT 166 166 I -> T (in dbSNP:rs1059516). FT /FTId=VAR_056303. FT VARIANT 187 187 R -> E (in allele A*66:02; requires 2 FT nucleotide substitutions). FT {ECO:0000269|PubMed:1940790, FT ECO:0000269|PubMed:2139695}. FT /FTId=VAR_004388. SQ SEQUENCE 365 AA; 41082 MW; A3272DBE4008328D CRC64; MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAQSQTDRV DLGTLRGYYN QSEDGSHTIQ RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WETAHEAEQW RAYLEGRCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV // ID 1A68_HUMAN Reviewed; 365 AA. AC P01891; O19673; O19695; O19794; O19795; O43907; O77938; O98010; AC P10315; P79505; Q9MYA5; Q9MYC4; Q9TQG7; Q9TQN5; Q9UIN2; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-FEB-2001, sequence version 4. DT 12-SEP-2018, entry version 179. DE RecName: Full=HLA class I histocompatibility antigen, A-68 alpha chain; DE AltName: Full=Aw-68; DE AltName: Full=HLA class I histocompatibility antigen, A-28 alpha chain; DE AltName: Full=MHC class I antigen A*68; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE A*68:02). RX PubMed=3496393; RA Holmes N., Ennis P., Wan A.M., Denney D.W., Parham P.; RT "Multiple genetic mechanisms have contributed to the generation of the RT HLA-A2/A28 family of class I MHC molecules."; RL J. Immunol. 139:936-941(1987). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE A*68:02). RA Domena J.D.; RL Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*68:03). RX PubMed=8881043; DOI=10.1007/s002510050172; RA Ellexson M., Lau M., Terasaki P., Hildebrand W.H.; RT "Molecular characterization of HLA-A*6803."; RL Immunogenetics 45:78-79(1996). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*68:08). RX PubMed=10395114; DOI=10.1034/j.1399-0039.1999.530614.x; RA Cox S.T., Arguello J.R., Marsh S.G.E., Boham E., Lau M., Kwan P.L., RA Madrigal J.A., Little A.-M.; RT "Sequence of HLA-A*6808."; RL Tissue Antigens 53:597-600(1999). RN [5] RP NUCLEOTIDE SEQUENCE (ALLELE A*68:011). RC TISSUE=Blood; RA Cox S.T.; RT "Confirmation of HLA-A*68011."; RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*68:17). RX PubMed=10885567; DOI=10.1034/j.1399-0039.2000.550509.x; RA Ramon D., Scott I., Cox S.T., Pesoa S., Vullo C., Little A.-M., RA Madrigal J.A.; RT "HLA-A*6817, identified in the Kolla Amerindians of north-west RT Argentina possesses a novel nucleotide substitution."; RL Tissue Antigens 55:453-454(2000). RN [7] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*68:06). RA Bei M., Hurley C.K.; RL Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE A*68:03). RC TISSUE=Blood; RX PubMed=9271640; DOI=10.1007/s002510050304; RA Vargas-Alarcon G., Martinez-Laso J., Gomez-Casado E., Perez-Blas M., RA Granados J., Alegre R., Alvarez M., Zuniga J., Arnaiz-Villena A.; RT "Description of HLA-A*6803 and A*68N in Mazatecan Indians from RT Mexico."; RL Immunogenetics 46:446-447(1997). RN [9] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*68:03). RC TISSUE=Blood; RA Blasczyk R.; RL Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*68:02). RA Edson S.M., Hurley C.K.; RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases. RN [11] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*68:09 AND A*68:10). RX PubMed=10852390; DOI=10.1034/j.1399-0039.2000.550412.x; RA Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R., RA Ng J., Hartzman R.J., Hurley C.K.; RT "Seventeen more novel HLA-A locus alleles."; RL Tissue Antigens 55:369-373(2000). RN [12] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-206 (ALLELE A*68:16). RX PubMed=10803837; DOI=10.1007/s002510050618; RA Gomez-Casado E., Martinez-Laso J., Gonzalez-Hevilla M., Longas J., RA Rubio I., Silvera-Redondo C., Garcia-Gomez A., Lowy E., RA Arnaiz-Villena A.; RT "A novel HLA-A*6816 allele possible generated by a point mutation in a RT Chilean from Punta Arenas (Magellan Strait)."; RL Immunogenetics 51:257-260(2000). RN [13] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*68:07 AND A*68:17). RX PubMed=11260503; DOI=10.1034/j.1399-0039.2001.057002095.x; RA Hickman H.D., Cavett J.W., Ellexson-Turner M.E., Sparkman J.N., RA Bennett T.T., Turner S., Sidebottom D.A., Trachtenberg E.A., RA Confer D.L., Hildebrand W.H.; RT "Non-conservative substitutions distinguish previously uncharacterized RT HLA-A molecules."; RL Tissue Antigens 57:95-102(2001). RN [14] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-297 (ALLELE A*68:01). RX PubMed=3877632; RA Holmes N., Parham P.; RT "Exon shuffling in vivo can generate novel HLA class I molecules."; RL EMBO J. 4:2849-2854(1985). RN [15] RP PROTEIN SEQUENCE OF 25-294 (A*68:01). RX PubMed=6179086; DOI=10.1073/pnas.79.12.3813; RA Lopez de Castro J.A., Strominger J.L., Strong D.M., Orr H.T.; RT "Structure of crossreactive human histocompatibility antigens HLA-A28 RT and HLA-A2: possible implications for the generation of HLA RT polymorphism."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3813-3817(1982). RN [16] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Platelet; RX PubMed=18088087; DOI=10.1021/pr0704130; RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., RA Schuetz C., Walter U., Gambaryan S., Sickmann A.; RT "Phosphoproteome of resting human platelets."; RL J. Proteome Res. 7:526-534(2008). RN [17] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., RA Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in RT a refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [18] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110. RC TISSUE=Liver; RX PubMed=19159218; DOI=10.1021/pr8008012; RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; RT "Glycoproteomics analysis of human liver tissue by combination of RT multiple enzyme digestion and hydrazide chemistry."; RL J. Proteome Res. 8:651-661(2009). RN [19] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [20] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356 AND SER-359, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [21] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350; SER-352; SER-356 RP AND SER-359, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [22] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [23] RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 25-294 (A*68:01). RX PubMed=1448153; DOI=10.1038/360364a0; RA Guo H.-C., Jardetzky T.S., Garrett T.P.J., Lane W.S., Strominger J.L., RA Wiley D.C.; RT "Different length peptides bind to HLA-Aw68 similarly at their ends RT but bulge out in the middle."; RL Nature 360:364-366(1992). RN [24] RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 25-294 (A*68:01). RX PubMed=1448154; DOI=10.1038/360367a0; RA Silver M.L., Guo H.-C., Strominger J.L., Wiley D.C.; RT "Atomic structure of a human MHC molecule presenting an influenza RT virus peptide."; RL Nature 360:367-369(1992). RN [25] RP X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 25-199 (A*68:01). RX PubMed=7862664; DOI=10.1073/pnas.92.4.1218; RA Collins E.J., Garboczi D.N., Karpusas M.N., Wiley D.C.; RT "The three-dimensional structure of a class I major histocompatibility RT complex molecule missing the alpha 3 domain of the heavy chain."; RL Proc. Natl. Acad. Sci. U.S.A. 92:1218-1221(1995). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of A-68 are known: A*68:01 CC (Aw68.1), A*68:02, A*68:03. A*68:04, A*68:05, A*68:06, A*68:07, CC A*68:08, A*68:09, A*68:10, A*68:16 and A*68:17. The sequence shown CC is that of A*68:01. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; U03861; AAA03602.1; -; mRNA. DR EMBL; X03070; CAB56605.1; -; Genomic_DNA. DR EMBL; X03071; CAB56606.1; -; Genomic_DNA. DR EMBL; U41057; AAB41292.1; -; mRNA. DR EMBL; AJ315642; CAC44382.1; -; Genomic_DNA. DR EMBL; AF144013; AAF74211.1; -; Genomic_DNA. DR EMBL; AJ245567; CAB59722.1; -; Genomic_DNA. DR EMBL; AH005127; AAB50567.1; -; Genomic_DNA. DR EMBL; U89946; AAB82079.1; -; Genomic_DNA. DR EMBL; U89947; AAB82080.1; -; Genomic_DNA. DR EMBL; AJ001274; CAA04647.1; -; mRNA. DR EMBL; AH006296; AAC25782.1; -; Genomic_DNA. DR EMBL; AH007538; AAD22270.1; -; Genomic_DNA. DR EMBL; AH007605; AAD27539.1; -; Genomic_DNA. DR EMBL; AJ223972; CAA11708.1; -; Genomic_DNA. DR EMBL; AH007201; AAD02208.1; -; Genomic_DNA. DR EMBL; AH009406; AAF73477.1; -; Genomic_DNA. DR PIR; A02187; HLHU28. DR PIR; A24671; HLHUAW. DR PIR; I38441; I38441. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR PDB; 1HSB; X-ray; 1.90 A; A=25-294. DR PDB; 1TMC; X-ray; 2.30 A; A=25-199. DR PDB; 2HLA; X-ray; 2.60 A; A=25-294. DR PDB; 4HWZ; X-ray; 2.40 A; A=25-298. DR PDB; 4HX1; X-ray; 1.80 A; A=25-296. DR PDB; 4I48; X-ray; 2.80 A; A=25-296. DR PDB; 6EI2; X-ray; 1.61 A; A=25-299. DR PDBsum; 1HSB; -. DR PDBsum; 1TMC; -. DR PDBsum; 2HLA; -. DR PDBsum; 4HWZ; -. DR PDBsum; 4HX1; -. DR PDBsum; 4I48; -. DR PDBsum; 6EI2; -. DR ProteinModelPortal; P01891; -. DR SMR; P01891; -. DR IntAct; P01891; 7. DR MINT; P01891; -. DR iPTMnet; P01891; -. DR SwissPalm; P01891; -. DR DMDM; 13124681; -. DR EPD; P01891; -. DR MaxQB; P01891; -. DR PeptideAtlas; P01891; -. DR PRIDE; P01891; -. DR Ensembl; ENST00000457879; ENSP00000403575; ENSG00000235657. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P01891; -. DR HOVERGEN; HBG016709; -. DR InParanoid; P01891; -. DR PhylomeDB; P01891; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR EvolutionaryTrace; P01891; -. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; IMP:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; IMP:UniProtKB. DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Direct protein sequencing; KW Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I; KW Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 {ECO:0000269|PubMed:6179086}. FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-68 alpha chain. FT /FTId=PRO_0000018830. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:18088087, FT ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:19159218}. FT DISULFID 125 188 FT DISULFID 227 283 FT VARIANT 36 36 V -> M (in allele A*68:02). FT {ECO:0000269|PubMed:3496393, FT ECO:0000269|Ref.10, ECO:0000269|Ref.2}. FT /FTId=VAR_004389. FT VARIANT 86 87 RN -> EE (in allele A*68:10). FT {ECO:0000269|PubMed:10852390}. FT /FTId=VAR_010362. FT VARIANT 89 89 R -> G (in dbSNP:rs199474430). FT /FTId=VAR_056304. FT VARIANT 94 94 Q -> H (in allele A*68:03, allele A*68:04 FT and allele A*68:05; dbSNP:rs78306866). FT {ECO:0000269|PubMed:8881043, FT ECO:0000269|PubMed:9271640, FT ECO:0000269|Ref.9}. FT /FTId=VAR_010363. FT VARIANT 97 97 T -> I (in allele A*68:04). FT /FTId=VAR_010364. FT VARIANT 98 98 D -> H (in allele A*68:05). FT /FTId=VAR_010365. FT VARIANT 101 101 D -> N (in dbSNP:rs1136688). FT /FTId=VAR_056305. FT VARIANT 121 121 M -> R (in allele A*68:02). FT {ECO:0000269|PubMed:3496393, FT ECO:0000269|Ref.10, ECO:0000269|Ref.2}. FT /FTId=VAR_004390. FT VARIANT 129 129 S -> P (in allele A*68:02; FT dbSNP:rs1136700). FT {ECO:0000269|PubMed:3496393, FT ECO:0000269|Ref.10, ECO:0000269|Ref.2}. FT /FTId=VAR_004391. FT VARIANT 133 133 F -> L (in dbSNP:rs1059488). FT /FTId=VAR_056306. FT VARIANT 138 138 R -> E (in allele A*68:06; requires 2 FT nucleotide substitutions). FT {ECO:0000269|PubMed:10852390}. FT /FTId=VAR_010366. FT VARIANT 138 138 R -> H (in allele A*68:02). FT {ECO:0000269|PubMed:3496393, FT ECO:0000269|Ref.10, ECO:0000269|Ref.2}. FT /FTId=VAR_004392. FT VARIANT 140 140 D -> H (in allele A*68:06 and allele FT A*68:07). {ECO:0000269|PubMed:10885567}. FT /FTId=VAR_010367. FT VARIANT 140 140 D -> V (in allele A*68:17). FT {ECO:0000269|PubMed:10885567, FT ECO:0000269|PubMed:11260503}. FT /FTId=VAR_010368. FT VARIANT 140 140 D -> Y (in allele A*68:02). FT {ECO:0000269|PubMed:3496393, FT ECO:0000269|Ref.10, ECO:0000269|Ref.2}. FT /FTId=VAR_004393. FT VARIANT 175 175 H -> L (in allele A*68:16). FT {ECO:0000269|PubMed:10803837}. FT /FTId=VAR_010369. FT VARIANT 180 180 W -> L (in allele A*68:08). FT {ECO:0000269|PubMed:10395114}. FT /FTId=VAR_010370. FT VARIANT 180 180 W -> Q (in allele A*68:09; requires 2 FT nucleotide substitutions). FT /FTId=VAR_010371. FT CONFLICT 206 206 T -> A (in Ref. 12; AAF74211). FT {ECO:0000305}. FT CONFLICT 231 231 S -> G (in Ref. 15; AA sequence). FT {ECO:0000305}. FT STRAND 27 36 {ECO:0000244|PDB:6EI2}. FT STRAND 41 43 {ECO:0000244|PDB:4HX1}. FT STRAND 45 52 {ECO:0000244|PDB:6EI2}. FT STRAND 55 61 {ECO:0000244|PDB:6EI2}. FT STRAND 64 66 {ECO:0000244|PDB:6EI2}. FT HELIX 74 76 {ECO:0000244|PDB:6EI2}. FT HELIX 81 108 {ECO:0000244|PDB:6EI2}. FT STRAND 113 115 {ECO:0000244|PDB:1TMC}. FT STRAND 118 127 {ECO:0000244|PDB:6EI2}. FT STRAND 133 142 {ECO:0000244|PDB:6EI2}. FT STRAND 145 150 {ECO:0000244|PDB:6EI2}. FT STRAND 157 159 {ECO:0000244|PDB:6EI2}. FT HELIX 162 173 {ECO:0000244|PDB:6EI2}. FT HELIX 176 185 {ECO:0000244|PDB:6EI2}. FT HELIX 187 198 {ECO:0000244|PDB:6EI2}. FT HELIX 200 203 {ECO:0000244|PDB:6EI2}. FT STRAND 210 235 {ECO:0000244|PDB:6EI2}. FT STRAND 238 243 {ECO:0000244|PDB:6EI2}. FT STRAND 246 248 {ECO:0000244|PDB:6EI2}. FT STRAND 252 254 {ECO:0000244|PDB:6EI2}. FT STRAND 261 263 {ECO:0000244|PDB:6EI2}. FT STRAND 265 274 {ECO:0000244|PDB:6EI2}. FT HELIX 278 280 {ECO:0000244|PDB:6EI2}. FT STRAND 281 286 {ECO:0000244|PDB:6EI2}. FT STRAND 290 292 {ECO:0000244|PDB:1HSB}. FT STRAND 294 296 {ECO:0000244|PDB:6EI2}. SQ SEQUENCE 365 AA; 40909 MW; 78539C59DB8B1DFC CRC64; MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAQSQTDRV DLGTLRGYYN QSEAGSHTIQ MMYGCDVGSD GRFLRGYRQD AYDGKDYIAL KEDLRSWTAA DMAAQTTKHK WEAAHVAEQW RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWVA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDVSL TACKV // ID 1A69_HUMAN Reviewed; 365 AA. AC P10316; B1PKZ3; DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot. DT 03-OCT-2006, sequence version 2. DT 12-SEP-2018, entry version 154. DE RecName: Full=HLA class I histocompatibility antigen, A-69 alpha chain; DE AltName: Full=Aw-69; DE AltName: Full=HLA class I histocompatibility antigen, A-28 alpha chain; DE AltName: Full=MHC class I antigen A*69; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*69:01). RA Yan L., Zhu F., He Y.; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-298 (ALLELE A*69:01). RX PubMed=3877632; RA Holmes N., Parham P.; RT "Exon shuffling in vivo can generate novel HLA class I molecules."; RL EMBO J. 4:2849-2854(1985). RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Platelet; RX PubMed=18088087; DOI=10.1021/pr0704130; RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., RA Schuetz C., Walter U., Gambaryan S., Sickmann A.; RT "Phosphoproteome of resting human platelets."; RL J. Proteome Res. 7:526-534(2008). RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., RA Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in RT a refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356 AND SER-359, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350; SER-352; SER-356 RP AND SER-359, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The only allele of A-69 known is A*69:01 which is CC shown here. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; EU445484; ACA35004.1; -; Genomic_DNA. DR EMBL; X03158; CAB56607.1; -; Genomic_DNA. DR EMBL; X03159; CAB56608.1; -; Genomic_DNA. DR PIR; B24671; HLHU69. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR ProteinModelPortal; P10316; -. DR SMR; P10316; -. DR IntAct; P10316; 1. DR iPTMnet; P10316; -. DR SwissPalm; P10316; -. DR DMDM; 115502347; -. DR EPD; P10316; -. DR MaxQB; P10316; -. DR PeptideAtlas; P10316; -. DR PRIDE; P10316; -. DR Ensembl; ENST00000457879; ENSP00000403575; ENSG00000235657. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P10316; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT CHAIN 1 365 HLA class I histocompatibility antigen, FT A-69 alpha chain. FT /FTId=PRO_0000080740. FT SIGNAL 1 24 {ECO:0000255}. FT TOPO_DOM 25 307 Extracellular. {ECO:0000255}. FT TRANSMEM 308 328 Helical. {ECO:0000255}. FT TOPO_DOM 329 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:18088087, FT ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 89 89 R -> G (in dbSNP:rs199474430). FT /FTId=VAR_056307. FT VARIANT 94 94 Q -> H (in dbSNP:rs78306866). FT /FTId=VAR_056308. FT VARIANT 101 101 D -> N (in dbSNP:rs1136688). FT /FTId=VAR_056309. SQ SEQUENCE 365 AA; 40977 MW; 050F1B01157EFDF6 CRC64; MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAQSQTDRV DLGTLRGYYN QSEAGSHTVQ RMYGCDVGSD WRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQTTKHK WEAAHVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDVSL TACKV // ID 1A74_HUMAN Reviewed; 365 AA. AC P30459; O19647; O43906; O46874; Q95IZ5; Q9UIN1; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 145. DE RecName: Full=HLA class I histocompatibility antigen, A-74 alpha chain; DE AltName: Full=Aw-19; DE AltName: Full=Aw-74; DE AltName: Full=MHC class I antigen A*74; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*74:01). RX PubMed=1431115; RA Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J., RA Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., RA Martell R.W., du Toit E.D., Parham P.; RT "Distinctive HLA-A,B antigens of black populations formed by RT interallelic conversion."; RL J. Immunol. 149:3411-3415(1992). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE A*74:01). RA Hurley C.K.; RL Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-206 (ALLELES A*74:02 AND A*74:03). RC TISSUE=Blood; RX PubMed=8896180; DOI=10.1111/j.1399-0039.1996.tb02630.x; RA Blasczyk R., Wehling J., Onaldi-Mohr D., Rebmann V., RA Chandanayingyong D., Grosse-Wilde H.; RT "Structural definition of the A*74 group: implications for matching in RT bone marrow transplantation with alternative donors."; RL Tissue Antigens 48:205-209(1996). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-206 (ALLELE A*74:04). RX PubMed=11169261; DOI=10.1034/j.1399-0039.2001.057001070.x; RA Cox S.T., Mcwhinnie A.J., Koester R.P., Heine U., Holman R., RA Madrigal A.J., Little A.-M.; RT "Further diversity at HLA-A and -B loci identified in Afro-Caribbean RT potential bone marrow donors."; RL Tissue Antigens 57:70-72(2001). RN [5] RP NUCLEOTIDE SEQUENCE OF 25-206 (ALLELE A*74:05). RX PubMed=11260503; DOI=10.1034/j.1399-0039.2001.057002095.x; RA Hickman H.D., Cavett J.W., Ellexson-Turner M.E., Sparkman J.N., RA Bennett T.T., Turner S., Sidebottom D.A., Trachtenberg E.A., RA Confer D.L., Hildebrand W.H.; RT "Non-conservative substitutions distinguish previously uncharacterized RT HLA-A molecules."; RL Tissue Antigens 57:95-102(2001). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343; TYR-344; SER-345; RP SER-349; SER-352; SER-356 AND SER-359, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of A-74 are known: A*74:01 CC A*74:02, A*74:03, A*74:04 and A*74:05. The sequence shown is that CC of A*74:01. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X61701; CAA43870.1; -; mRNA. DR EMBL; U17569; AAA56779.1; -; mRNA. DR EMBL; U17570; AAA56780.1; -; mRNA. DR EMBL; AJ223060; CAA11063.1; -; mRNA. DR EMBL; AJ002678; CAA05681.1; -; mRNA. DR EMBL; AJ249370; CAB58124.1; -; Genomic_DNA. DR EMBL; AH010693; AAK49188.1; -; Genomic_DNA. DR PIR; I37482; I37482. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR ProteinModelPortal; P30459; -. DR SMR; P30459; -. DR IntAct; P30459; 1. DR iPTMnet; P30459; -. DR SwissPalm; P30459; -. DR DMDM; 231375; -. DR EPD; P30459; -. DR MaxQB; P30459; -. DR PeptideAtlas; P30459; -. DR PRIDE; P30459; -. DR Ensembl; ENST00000454091; ENSP00000410645; ENSG00000223980. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_P30459; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-6798695; Neutrophil degranulation. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030667; C:secretory granule membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-74 alpha chain. FT /FTId=PRO_0000018831. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01892}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 23 23 R -> W (in allele A*74:02; FT dbSNP:rs41564012). FT {ECO:0000269|PubMed:8896180}. FT /FTId=VAR_010375. FT VARIANT 86 86 Q -> G (in allele A*74:04; requires 2 FT nucleotide substitutions). FT {ECO:0000269|PubMed:11169261}. FT /FTId=VAR_016612. FT VARIANT 89 89 R -> G (in dbSNP:rs199474430). FT /FTId=VAR_056310. FT VARIANT 90 90 N -> K (in allele A*74:04). FT {ECO:0000269|PubMed:11169261}. FT /FTId=VAR_016613. FT VARIANT 97 97 T -> A (in allele A*74:05). FT {ECO:0000269|PubMed:11260503}. FT /FTId=VAR_016614. FT VARIANT 103 103 G -> A (in allele A*74:03). FT {ECO:0000269|PubMed:8896180}. FT /FTId=VAR_016615. FT VARIANT 151 151 N -> K (in dbSNP:rs1059509). FT /FTId=VAR_056311. FT VARIANT 166 166 I -> T (in dbSNP:rs1059516). FT /FTId=VAR_056312. SQ SEQUENCE 365 AA; 40891 MW; C94BF2569A852371 CRC64; MAVMAPRTLL LLLLGALALT QTRAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAHSQTDRV DLGTLRGYYN QSEAGSHTIQ MMYGCDVGPD GRLLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA MFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV // ID 1A80_HUMAN Reviewed; 365 AA. AC Q09160; DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1995, sequence version 1. DT 12-SEP-2018, entry version 138. DE RecName: Full=HLA class I histocompatibility antigen, A-80 alpha chain; DE AltName: Full=Aw-80; DE AltName: Full=HLA class I histocompatibility antigen, A-1 alpha chain; DE AltName: Full=MHC class I antigen A*80; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*80:01). RX PubMed=8188325; DOI=10.1007/BF00176169; RA Balas A., Garcia-Sanchez F., Gomez-Reino F., Vicario J.L.; RT "Characterization of a new and highly distinguishable HLA-A allele in RT a Spanish family."; RL Immunogenetics 39:452-452(1994). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*80:01). RX PubMed=8284791; DOI=10.1111/j.1399-0039.1993.tb02186.x; RA Domena J.D., Hildebrand W.H., Bias W.B., Parham P.; RT "A sixth family of HLA-A alleles defined by HLA-A*8001."; RL Tissue Antigens 42:156-159(1993). RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Platelet; RX PubMed=18088087; DOI=10.1021/pr0704130; RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., RA Schuetz C., Walter U., Gambaryan S., Sickmann A.; RT "Phosphoproteome of resting human platelets."; RL J. Proteome Res. 7:526-534(2008). RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., RA Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in RT a refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356 AND SER-359, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350; SER-352; SER-356 RP AND SER-359, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [8] RP VARIANT [LARGE SCALE ANALYSIS] THR-166, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The only allele of A-80 known is A*80:01 which is CC shown here. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; U03754; AAC04322.1; -; mRNA. DR EMBL; L18898; AAA17012.1; -; mRNA. DR PIR; I59638; I38439. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR ProteinModelPortal; Q09160; -. DR SMR; Q09160; -. DR iPTMnet; Q09160; -. DR SwissPalm; Q09160; -. DR DMDM; 1168212; -. DR EPD; Q09160; -. DR MaxQB; Q09160; -. DR PeptideAtlas; Q09160; -. DR PRIDE; Q09160; -. DR Ensembl; ENST00000431930; ENSP00000406366; ENSG00000229215. DR Ensembl; ENST00000443552; ENSP00000404678; ENSG00000224320. DR DisGeNET; 3105; -. DR GeneCards; HLA-A; -. DR HGNC; HGNC:4931; HLA-A. DR MalaCards; HLA-A; -. DR MIM; 142800; gene. DR neXtProt; NX_Q09160; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-A; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-80 alpha chain. FT /FTId=PRO_0000018832. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 343 343 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 344 344 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 345 345 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 349 349 Phosphoserine. FT {ECO:0000250|UniProtKB:P18462}. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 352 352 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:18088087, FT ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:23186163, FT ECO:0000244|PubMed:24275569}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 121 121 I -> M (in dbSNP:rs1136695). FT /FTId=VAR_056313. FT VARIANT 129 129 S -> P (in dbSNP:rs1136700). FT /FTId=VAR_056314. FT VARIANT 131 131 G -> W (in dbSNP:rs1136702). FT /FTId=VAR_056315. FT VARIANT 133 133 F -> L (in dbSNP:rs1059488). FT /FTId=VAR_056316. FT VARIANT 151 151 N -> K (in dbSNP:rs1059509). FT /FTId=VAR_056317. FT VARIANT 166 166 I -> T (in dbSNP:rs1059516). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056318. FT VARIANT 169 169 R -> H (in dbSNP:rs1059520). FT /FTId=VAR_056319. FT VARIANT 205 205 R -> H (in dbSNP:rs17185861). FT /FTId=VAR_056320. SQ SEQUENCE 365 AA; 40792 MW; CE1BC1CD60CA8FA8 CRC64; MAVMPPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDSQFVQF DSDAASQRME PRAPWIEQEE PEYWDEETRN VKAHSQTNRA NLGTLRGYYN QSEDGSHTIQ IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAARRAEQL RAYLEGECVD GLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGKEKR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IIAGLVLLGA VIAGAVVAAV MWRKKSSVRK GGSYSQAASS DSAQGSDVSL TACKV // ID 1B01_GORGO Reviewed; 362 AA. AC P30379; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 28-FEB-2018, entry version 88. DE RecName: Full=Class I histocompatibility antigen, Gogo-B*0101 alpha chain; DE Flags: Precursor; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1744581; DOI=10.1084/jem.174.6.1491; RA Lawlor D.A., Warren E., Taylor P., Parham P.; RT "Gorilla class I major histocompatibility complex alleles: comparison RT to human and chimpanzee class I."; RL J. Exp. Med. 174:1491-1509(1991). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X60255; CAA42807.1; -; mRNA. DR PIR; JH0539; JH0539. DR ProteinModelPortal; P30379; -. DR SMR; P30379; -. DR PRIDE; P30379; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000001519; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 362 Class I histocompatibility antigen, Gogo- FT B*0101 alpha chain. FT /FTId=PRO_0000018901. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 362 AA; 40171 MW; 419EEE29817165A4 CRC64; MRVTAPRTLL LLLSAALALT ETWAGSHSMR YFDTAVSRPG RGEPRFITVG YVDDTQFVRF DSDAASPRME PRAPWIEQEG PEYWDRETQT SKAQAQTDRE NLRIALRYYN QSEAGSHTIQ RMFGCDVGPD GRLLRGYSQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQL RAYLEGTCVE WLRRYLENGR ETLQRADTPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEER YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVTAV ICRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B01_PANTR Reviewed; 359 AA. AC P13750; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 25-OCT-2017, entry version 100. DE RecName: Full=Patr class I histocompatibility antigen, B-1 alpha chain; DE AltName: Full=ChLa class I histocompatibility antigen, B-1 alpha chain; DE Flags: Precursor; Fragment; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2460344; RA Mayer W.E., Jonker M., Klein D., Ivanyi P., van Seventer G., Klein J.; RT "Nucleotide sequences of chimpanzee MHC class I alleles: evidence for RT trans-species mode of evolution."; RL EMBO J. 7:2765-2774(1988). RN [2] RP SEQUENCE REVISION. RA Mayer W.; RL Submitted (FEB-1989) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X13115; CAA31507.1; -; mRNA. DR UniGene; Ptr.1473; -. DR ProteinModelPortal; P13750; -. DR SMR; P13750; -. DR PRIDE; P13750; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000002277; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL <1 20 {ECO:0000250}. FT CHAIN 21 359 Patr class I histocompatibility antigen, FT B-1 alpha chain. FT /FTId=PRO_0000018916. FT TOPO_DOM 21 305 Extracellular. {ECO:0000255}. FT TRANSMEM 306 329 Helical. {ECO:0000255}. FT TOPO_DOM 330 359 Cytoplasmic. {ECO:0000255}. FT DOMAIN 205 291 Ig-like C1-type. FT REGION 21 110 Alpha-1. FT REGION 111 202 Alpha-2. FT REGION 203 294 Alpha-3. FT REGION 295 305 Connecting peptide. FT MOD_RES 353 353 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT CARBOHYD 106 106 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 121 184 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 223 279 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT NON_TER 1 1 SQ SEQUENCE 359 AA; 40174 MW; 858ACBAF74D6829D CRC64; APRTVLLLLS AALALTETWA GSHSMRYFYT SVSRPGRGEP RFITVGYVDD TQFVRFDSDA ASPRMEPRAP WIEQEGPEYW DRETRNMKAS AQTDRENLRI ALRYYNQSEA GSHTWQTMYG CDMGPDGRLL RGYGQYAYDG KDYIALNEDL SSWTAADTAA QITQRKWEAA REAEQRRAYL EGTCVEWLRR YLENGKETLQ RADPPKTHVT HHPISDHEAT LRCWALGFYP AEITLTWQRD GEDQTQDTEL VETRPEGDRT FQKWAAVVVP SGEEQRYTCH VQHEGLPKPL TLRWEPSSQS TIPIVGIVAG LAVLVVTVAV VAVVAAVMCR RKSSGGKGGS YSQAASSDSA QGSDVSLTA // ID 1B02_GORGO Reviewed; 362 AA. AC P30380; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 23-MAY-2018, entry version 88. DE RecName: Full=Class I histocompatibility antigen, Gogo-B*0102 alpha chain; DE Flags: Precursor; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1744581; DOI=10.1084/jem.174.6.1491; RA Lawlor D.A., Warren E., Taylor P., Parham P.; RT "Gorilla class I major histocompatibility complex alleles: comparison RT to human and chimpanzee class I."; RL J. Exp. Med. 174:1491-1509(1991). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X60693; CAA43101.1; -; mRNA. DR PIR; JH0540; JH0540. DR ProteinModelPortal; P30380; -. DR SMR; P30380; -. DR PRIDE; P30380; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000001519; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 362 Class I histocompatibility antigen, Gogo- FT B*0102 alpha chain. FT /FTId=PRO_0000018902. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 362 AA; 40205 MW; E19EEE2B7CC7BECD CRC64; MRVTAPRTLL LLLSAALALT ETWAGSHSMR YFDTAVSRPG RGEPRFITVG YVDDTQFVRF DSDAASPRME PRAPWIEQEG PEYWDRETQT SKAQAQTDRE NLRIALRYYN QSEAGSHTFQ RMFGCDVGPD GRLLRGYSQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQL RAYLEGTCVE WLRRYLENGR ETLQRADTPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEER YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVTAV ICRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B02_PANTR Reviewed; 362 AA. AC P13751; Q9MXK0; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 23-MAY-2018, entry version 109. DE RecName: Full=Patr class I histocompatibility antigen, B-2 alpha chain; DE AltName: Full=ChLa class I histocompatibility antigen, B-2 alpha chain; DE Flags: Precursor; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2460344; RA Mayer W.E., Jonker M., Klein D., Ivanyi P., van Seventer G., Klein J.; RT "Nucleotide sequences of chimpanzee MHC class I alleles: evidence for RT trans-species mode of evolution."; RL EMBO J. 7:2765-2774(1988). RN [2] RP SEQUENCE REVISION. RA Mayer W.; RL Submitted (FEB-1989) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Blood; RX PubMed=10866106; DOI=10.1007/s002510050638; RA de Groot N.G., Otting N., Arguello R., Watkins D.I., Doxiadis G.G., RA Madrigal J.A., Bontrop R.E.; RT "Major histocompatibility complex class I diversity in a West African RT chimpanzee population: implications for HIV research."; RL Immunogenetics 51:398-409(2000). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X13116; CAA31508.1; -; mRNA. DR EMBL; AF168411; AAF72792.2; -; mRNA. DR PIR; S03538; S03538. DR RefSeq; NP_001009081.1; NM_001009081.1. DR UniGene; Ptr.1473; -. DR ProteinModelPortal; P13751; -. DR SMR; P13751; -. DR GeneID; 450202; -. DR KEGG; ptr:450202; -. DR CTD; 450202; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR Proteomes; UP000002277; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 362 Patr class I histocompatibility antigen, FT B-2 alpha chain. FT /FTId=PRO_0000018917. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 362 AA; 40488 MW; FFDB2991044DAA83 CRC64; MQVTAPRTVL LLLSAALALT ETWAGSHSMK YFYTAVSRPG RGEPRFISVG YVDDTQFVWF DSDAASPREE PRAPWIEQEG PEYWDRETQI SKTNAQTYRE SLRNLRGYYN QSEAGSHIIQ RMYGCDMGPD GRLLRGYEQY AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARWAEQL RAYLEGTCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B03_GORGO Reviewed; 362 AA. AC P30381; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 23-MAY-2018, entry version 90. DE RecName: Full=Class I histocompatibility antigen, Gogo-B*0103 alpha chain; DE Flags: Precursor; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1744581; DOI=10.1084/jem.174.6.1491; RA Lawlor D.A., Warren E., Taylor P., Parham P.; RT "Gorilla class I major histocompatibility complex alleles: comparison RT to human and chimpanzee class I."; RL J. Exp. Med. 174:1491-1509(1991). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X60254; CAA42806.1; -; mRNA. DR PIR; JH0541; JH0541. DR ProteinModelPortal; P30381; -. DR SMR; P30381; -. DR STRING; 9593.ENSGGOP00000023616; -. DR PRIDE; P30381; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000001519; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 362 Class I histocompatibility antigen, Gogo- FT B*0103 alpha chain. FT /FTId=PRO_0000018903. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 362 AA; 40249 MW; 3DEE82572BD81469 CRC64; MRVTAPRTLL LLLSAALALT ETWAGSHSMR YFDTAVSRPG RGEPRFITVG YVDDTQFVRF DSDAASPRME PRAPWIEQEG PEYWDRETQT SKAQAQTDRE NLRIALRYYN QSEAGSHTIQ WMYGCDMGPD GRLLRGYSQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQL RAYLEGTCVE WLRRYLENGR ETLQRADTPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEER YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVTAV ICRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B04_GORGO Reviewed; 363 AA. AC P30382; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 28-FEB-2018, entry version 92. DE RecName: Full=Class I histocompatibility antigen, Gogo-B*0201 alpha chain; DE Flags: Precursor; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1744581; DOI=10.1084/jem.174.6.1491; RA Lawlor D.A., Warren E., Taylor P., Parham P.; RT "Gorilla class I major histocompatibility complex alleles: comparison RT to human and chimpanzee class I."; RL J. Exp. Med. 174:1491-1509(1991). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X60253; CAA42805.1; -; mRNA. DR PIR; JH0542; JH0542. DR ProteinModelPortal; P30382; -. DR SMR; P30382; -. DR PRIDE; P30382; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000001519; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 363 Class I histocompatibility antigen, Gogo- FT B*0201 alpha chain. FT /FTId=PRO_0000018904. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 363 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 363 AA; 40439 MW; A8CA366ED9A2B264 CRC64; MQVTAPRTLL LLLSAALALT ETWAGSHSMR YFHTAMSRPG RGEPRFITVG YVDDTQFVWF DSDAASPRKE PRTPWIEQEG PEYWDRETQI SKTNTQTYRV GLGTLRGYYN QSEDGSHTIQ RMYGCDMGPD GRLLRGYSQL AYDGKDYLAL NEDLSSWTAA DTAAQITQRK WEAARAAEQE RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCRVQHEGL PEPLTLRWEP SSQSTIPIVG IVAGLAVLVV TVAVVAVVAA VMCRRKSSGG KGGSYSQAAS SDSAQGSDVS LTA // ID 1B07_HUMAN Reviewed; 362 AA. AC P01889; Q29638; Q29681; Q29854; Q29861; Q31613; Q5SRJ2; Q9GIX1; AC Q9TP95; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1991, sequence version 3. DT 12-SEP-2018, entry version 190. DE RecName: Full=HLA class I histocompatibility antigen, B-7 alpha chain; DE AltName: Full=MHC class I antigen B*7; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:02). RX PubMed=2320591; DOI=10.1073/pnas.87.7.2833; RA Ennis P.D., Zemmour J., Salter R.D., Parham P.; RT "Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: RT frequency and nature of errors produced in amplification."; RL Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE B*07:02). RX PubMed=2700944; RA Parham P., Benjamin R.J., Chen B.P., Clayberger C., Ennis P.D., RA Krensky A.M., Lawlor D.A., Littman D.R., Norment A.M., Orr H.T., RA Salter R.D., Zemmour J.; RT "Diversity of class I HLA molecules: functional and evolutionary RT interactions with T cells."; RL Cold Spring Harb. Symp. Quant. Biol. 54:529-543(1989). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:02). RX PubMed=2993161; DOI=10.1007/BF00563508; RA Sood A.K., Pan J., Biro P.A., Pereira D., Srivastava R., Reddy V.B., RA Duceman B.W., Weissman S.M.; RT "Structure and polymorphism of class I MHC antigen mRNA."; RL Immunogenetics 22:101-121(1985). RN [4] RP NUCLEOTIDE SEQUENCE (ALLELE B*07:02). RA Ellexson M.E., Zhang L., Hildebrand W.H.; RL Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:03). RX PubMed=8106270; DOI=10.1016/0198-8859(93)90533-7; RA Bergmans A., Tijssen H., Lardy J., Reekers P.; RT "Complete nucleotide sequence of HLA-B*0703, a B7-variant (BPOT)."; RL Hum. Immunol. 38:159-162(1993). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:04). RX PubMed=7652739; DOI=10.1111/j.1399-0039.1995.tb02461.x; RA Kubens B.S., Arnett K.L., Adams E.J., Parham P., Grosse-Wilde H.; RT "Definition of a new HLA-B7 subtype (B*0704) by isoelectric focusing, RT family studies and DNA sequence analysis."; RL Tissue Antigens 45:322-327(1995). RN [7] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:05). RX PubMed=7878658; DOI=10.1111/j.1399-0039.1994.tb02402.x; RA Arnett K.L., Adams E.J., Domena J.D., Parham P.; RT "Structure of a novel subtype of B7 (B*0705) isolated from a Chinese RT individual."; RL Tissue Antigens 44:318-321(1994). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*07:03 AND B*07:05). RX PubMed=8537119; RA Smith K.D., Epperson D.F., Lutz C.T.; RT "Alloreactive cytotoxic T-lymphocyte-defined HLA-B7 subtypes differ in RT peptide antigen presentation."; RL Immunogenetics 43:27-37(1996). RN [9] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:06). RX PubMed=8773323; DOI=10.1111/j.1399-0039.1996.tb02561.x; RA Sanz L., Vilches C., de Pablo R., Bunce M., Moreno M.E., Kreisler M.; RT "Haplotypic association of two new HLA class I alleles: Cw*15052 and RT B*0706: evolutionary relationships of HLA-Cw*15 alleles."; RL Tissue Antigens 47:329-332(1996). RN [10] RP NUCLEOTIDE SEQUENCE (ALLELE B*07:18). RA Bettinotti M.P., Hadzikadic L., Dhillon G., Barracchini K., RA Marincola F.M.; RT "A new HLA-B allele."; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. RN [11] RP NUCLEOTIDE SEQUENCE (ALLELE B*07:02). RA Marsh S.G.E.; RT "Intron sequences of HLA class I."; RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. RN [12] RP NUCLEOTIDE SEQUENCE (ALLELE B*07:02). RC TISSUE=Blood; RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [13] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Subthalamic nucleus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [14] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [15] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*07:24). RC TISSUE=Peripheral blood; RX PubMed=11556973; DOI=10.1034/j.1399-0039.2001.057005471.x; RA Middleton D., Curran M.D., Anholts J.D., Reilly E.R., Schreuder G.M.; RT "Characterisation of a new HLA-B allele, HLA-B*0724."; RL Tissue Antigens 57:471-473(2001). RN [16] RP PROTEIN SEQUENCE OF 25-295 (B*07:02). RX PubMed=518865; DOI=10.1021/bi00592a030; RA Orr H.T., Lopez de Castro J.A., Lancet D., Strominger J.L.; RT "Complete amino acid sequence of a papain-solubilized human RT histocompatibility antigen, HLA-B7. 2. Sequence determination and RT search for homologies."; RL Biochemistry 18:5711-5720(1979). RN [17] RP INTERACTION WITH HTLV-1 ACCESSORY PROTEIN P12I (MICROBIAL INFECTION). RX PubMed=11390610; DOI=10.1128/JVI.75.13.6086-6094.2001; RA Johnson J.M., Nicot C., Fullen J., Ciminale V., Casareto L., RA Mulloy J.C., Jacobson S., Franchini G.; RT "Free major histocompatibility complex class I heavy chain is RT preferentially targeted for degradation by human T-cell RT leukemia/lymphotropic virus type 1 p12(I) protein."; RL J. Virol. 75:6086-6094(2001). RN [18] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110. RC TISSUE=Liver; RX PubMed=19159218; DOI=10.1021/pr8008012; RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; RT "Glycoproteomics analysis of human liver tissue by combination of RT multiple enzyme digestion and hydrazide chemistry."; RL J. Proteome Res. 8:651-661(2009). RN [19] RP VARIANT [LARGE SCALE ANALYSIS] THR-65, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [20] RP VARIANT [LARGE SCALE ANALYSIS] ASN-138, VARIANT [LARGE SCALE ANALYSIS] RP SER-155, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBUNIT: (Microbial infection) Interacts with HTLV-1 accessory CC protein p12I. {ECO:0000269|PubMed:11390610}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-7 are known: B*07:02 CC (B7.2), B*07:03 (BPOT), B*07:04, B*07:05, B*07:06 (B7_L79), CC B*07:18 and B*07:24. The sequence shown is B*07:02. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M32317; AAA36230.1; -; mRNA. DR EMBL; M16102; AAA59622.1; ALT_SEQ; mRNA. DR EMBL; U29057; AAA91229.1; -; mRNA. DR EMBL; X64454; CAA45785.1; -; mRNA. DR EMBL; U04245; AAA87398.1; -; mRNA. DR EMBL; L33922; AAA65639.1; -; mRNA. DR EMBL; U21052; AAA92563.1; -; mRNA. DR EMBL; U21053; AAA92564.1; -; mRNA. DR EMBL; X91749; CAA62864.1; -; mRNA. DR EMBL; AF189017; AAF01052.1; -; mRNA. DR EMBL; AJ309047; CAC35468.1; -; Genomic_DNA. DR EMBL; AJ292075; CAC33440.1; -; Genomic_DNA. DR EMBL; AL671883; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AK313911; BAG36634.1; -; mRNA. DR EMBL; AJ401222; CAC10402.1; -; Genomic_DNA. DR CCDS; CCDS34394.1; -. DR PIR; B35997; HLHUB7. DR PIR; I54418; I54418. DR PIR; I59651; I59651. DR PIR; S60601; S60601. DR RefSeq; NP_005505.2; NM_005514.7. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 3VCL; X-ray; 1.70 A; A=25-299. DR PDB; 4U1H; X-ray; 1.59 A; A=25-300. DR PDB; 4U1K; X-ray; 2.09 A; A/D=25-300. DR PDB; 5EO0; X-ray; 1.70 A; A=25-299. DR PDB; 5EO1; X-ray; 1.85 A; A=25-299. DR PDB; 5WMN; X-ray; 1.82 A; A/C=25-300. DR PDB; 5WMO; X-ray; 1.62 A; A=25-300. DR PDB; 5WMP; X-ray; 1.60 A; A=25-300. DR PDB; 6AT5; X-ray; 1.50 A; A=1-362. DR PDB; 6AVF; X-ray; 2.03 A; H=1-362. DR PDB; 6AVG; X-ray; 2.60 A; F/G=1-362. DR PDBsum; 3VCL; -. DR PDBsum; 4U1H; -. DR PDBsum; 4U1K; -. DR PDBsum; 5EO0; -. DR PDBsum; 5EO1; -. DR PDBsum; 5WMN; -. DR PDBsum; 5WMO; -. DR PDBsum; 5WMP; -. DR PDBsum; 6AT5; -. DR PDBsum; 6AVF; -. DR PDBsum; 6AVG; -. DR ProteinModelPortal; P01889; -. DR SMR; P01889; -. DR BioGrid; 109351; 108. DR IntAct; P01889; 17. DR STRING; 9606.ENSP00000399168; -. DR iPTMnet; P01889; -. DR SwissPalm; P01889; -. DR BioMuta; ZCCHC6; -. DR DMDM; 122162; -. DR EPD; P01889; -. DR MaxQB; P01889; -. DR PaxDb; P01889; -. DR PeptideAtlas; P01889; -. DR PRIDE; P01889; -. DR Ensembl; ENST00000412585; ENSP00000399168; ENSG00000234745. DR GeneID; 3106; -. DR KEGG; hsa:3106; -. DR CTD; 3106; -. DR DisGeNET; 3106; -. DR EuPathDB; HostDB:ENSG00000234745.9; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR HPA; CAB015418; -. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P01889; -. DR OpenTargets; ENSG00000234745; -. DR PharmGKB; PA35056; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; VPGYYNQ; -. DR OrthoDB; EOG091G09OH; -. DR PhylomeDB; P01889; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-6798695; Neutrophil degranulation. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR SIGNOR; P01889; -. DR ChiTaRS; HLA-B; human. DR GeneWiki; HLA-B; -. DR GenomeRNAi; 3106; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000234745; Expressed in 92 organ(s), highest expression level in blood. DR CleanEx; HS_HLA-B; -. DR ExpressionAtlas; P01889; baseline and differential. DR Genevisible; P01889; HS. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB. DR GO; GO:0016020; C:membrane; HDA:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030667; C:secretory granule membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0005102; F:signaling receptor binding; IPI:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome. DR GO; GO:0042270; P:protection from natural killer cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:2001198; P:regulation of dendritic cell differentiation; IMP:BHF-UCL. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0032655; P:regulation of interleukin-12 production; IMP:BHF-UCL. DR GO; GO:0032675; P:regulation of interleukin-6 production; IMP:BHF-UCL. DR GO; GO:0002667; P:regulation of T cell anergy; IMP:BHF-UCL. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR GO; GO:0016032; P:viral process; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Direct protein sequencing; KW Disulfide bond; Glycoprotein; Host-virus interaction; Immunity; KW Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 {ECO:0000269|PubMed:518865}. FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-7 alpha chain. FT /FTId=PRO_0000018833. FT TOPO_DOM 25 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:19159218}. FT DISULFID 125 188 FT DISULFID 227 283 FT VARIANT 4 4 M -> T (in dbSNP:rs1050458). FT /FTId=VAR_050332. FT VARIANT 9 9 V -> L (in dbSNP:rs1050462). FT /FTId=VAR_050333. FT VARIANT 17 17 L -> V (in dbSNP:rs1131165). FT /FTId=VAR_050334. FT VARIANT 35 35 S -> A (in dbSNP:rs1131170). FT /FTId=VAR_050335. FT VARIANT 36 36 V -> M (in dbSNP:rs1050486). FT /FTId=VAR_050336. FT VARIANT 48 48 S -> A (in dbSNP:rs713031). FT /FTId=VAR_061386. FT VARIANT 48 48 S -> P (in dbSNP:rs713031). FT /FTId=VAR_061387. FT VARIANT 48 48 S -> T (in dbSNP:rs713031). FT /FTId=VAR_061388. FT VARIANT 65 65 A -> T (in dbSNP:rs1050529). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_050337. FT VARIANT 87 87 N -> D (in dbSNP:rs1050570). FT /FTId=VAR_050338. FT VARIANT 87 87 N -> K (in dbSNP:rs1065386). FT /FTId=VAR_059467. FT VARIANT 93 95 AQA -> TNT (in allele B*07:03). FT /FTId=VAR_016351. FT VARIANT 97 97 T -> A (in dbSNP:rs1050393). FT /FTId=VAR_050339. FT VARIANT 98 98 D -> Y (in dbSNP:rs1131215). FT /FTId=VAR_059468. FT VARIANT 101 101 S -> N (in dbSNP:rs1050388). FT /FTId=VAR_050340. FT VARIANT 118 119 TL -> II (in allele B*07:18; FT dbSNP:rs796332753). FT /FTId=VAR_016352. FT VARIANT 121 121 S -> R (in allele B*07:18; FT dbSNP:rs1140412). FT /FTId=VAR_016353. FT VARIANT 137 137 H -> Y (in dbSNP:rs1050379). FT /FTId=VAR_050341. FT VARIANT 138 138 D -> H (in dbSNP:rs709055). FT /FTId=VAR_061389. FT VARIANT 138 138 D -> N (in allele B*07:05 and allele FT B*07:06; dbSNP:rs709055). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_016354. FT VARIANT 155 155 R -> S (in dbSNP:rs1050654). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_050342. FT VARIANT 180 180 R -> D (in allele B*07:04; requires 2 FT nucleotide substitutions). FT /FTId=VAR_016355. FT VARIANT 187 187 E -> A (in dbSNP:rs2308466). FT /FTId=VAR_059469. FT VARIANT 187 187 E -> G (in dbSNP:rs2308466). FT /FTId=VAR_059470. FT VARIANT 187 187 E -> K (in dbSNP:rs2523600). FT /FTId=VAR_059471. FT VARIANT 187 187 E -> L (in allele B*07:24; requires 2 FT nucleotide substitutions). FT /FTId=VAR_016616. FT VARIANT 187 187 E -> Q (in dbSNP:rs2523600). FT /FTId=VAR_059472. FT VARIANT 187 187 E -> V (in dbSNP:rs2308466). FT /FTId=VAR_059473. FT VARIANT 195 195 Y -> H (in dbSNP:rs1050696). FT /FTId=VAR_050343. FT VARIANT 306 306 V -> I (in allele B*07:05; FT dbSNP:rs1131500). FT /FTId=VAR_016356. FT VARIANT 329 329 A -> T (in dbSNP:rs1051488). FT /FTId=VAR_050344. FT VARIANT 349 349 C -> S (in dbSNP:rs2308655). FT /FTId=VAR_061390. FT VARIANT 349 349 C -> Y (in dbSNP:rs2308655). FT /FTId=VAR_061391. FT CONFLICT 15 18 AALA -> GPW (in Ref. 3; AAA59622). FT {ECO:0000305}. FT CONFLICT 266 266 Q -> E (in Ref. 16; AA sequence). FT {ECO:0000305}. FT CONFLICT 268 268 W -> S (in Ref. 3; AAA59622). FT {ECO:0000305}. FT CONFLICT 297 297 R -> G (in Ref. 3; AAA59622). FT {ECO:0000305}. FT CONFLICT 314 315 GL -> RP (in Ref. 3; AAA59622). FT {ECO:0000305}. FT STRAND 27 36 {ECO:0000244|PDB:6AT5}. FT STRAND 41 43 {ECO:0000244|PDB:5WMN}. FT STRAND 45 52 {ECO:0000244|PDB:6AT5}. FT STRAND 55 61 {ECO:0000244|PDB:6AT5}. FT STRAND 64 66 {ECO:0000244|PDB:6AT5}. FT STRAND 70 73 {ECO:0000244|PDB:4U1K}. FT HELIX 74 76 {ECO:0000244|PDB:6AT5}. FT HELIX 81 108 {ECO:0000244|PDB:6AT5}. FT STRAND 113 115 {ECO:0000244|PDB:6AT5}. FT STRAND 118 127 {ECO:0000244|PDB:6AT5}. FT STRAND 133 142 {ECO:0000244|PDB:6AT5}. FT STRAND 145 150 {ECO:0000244|PDB:6AT5}. FT STRAND 157 161 {ECO:0000244|PDB:6AT5}. FT HELIX 162 173 {ECO:0000244|PDB:6AT5}. FT HELIX 176 185 {ECO:0000244|PDB:6AT5}. FT HELIX 187 198 {ECO:0000244|PDB:6AT5}. FT HELIX 200 203 {ECO:0000244|PDB:6AT5}. FT STRAND 210 219 {ECO:0000244|PDB:6AT5}. FT STRAND 222 235 {ECO:0000244|PDB:6AT5}. FT STRAND 238 243 {ECO:0000244|PDB:6AT5}. FT TURN 249 251 {ECO:0000244|PDB:6AT5}. FT STRAND 252 254 {ECO:0000244|PDB:6AT5}. FT STRAND 261 263 {ECO:0000244|PDB:6AT5}. FT STRAND 265 274 {ECO:0000244|PDB:6AT5}. FT HELIX 278 280 {ECO:0000244|PDB:6AT5}. FT STRAND 281 286 {ECO:0000244|PDB:6AT5}. FT STRAND 290 292 {ECO:0000244|PDB:3VCL}. FT STRAND 294 296 {ECO:0000244|PDB:6AT5}. SQ SEQUENCE 362 AA; 40460 MW; 5E5A7BDE031403D6 CRC64; MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHDQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQR RAYLEGECVE WLRRYLENGK DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA // ID 1B08_HUMAN Reviewed; 362 AA. AC P30460; O62901; O95730; O98140; P79542; Q95369; Q95J00; Q9GJ20; AC Q9MY78; Q9MYF4; Q9TQH6; Q9TQM2; Q9UQT0; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 182. DE RecName: Full=HLA class I histocompatibility antigen, B-8 alpha chain; DE AltName: Full=MHC class I antigen B*8; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*08:01). RX PubMed=2715640; RA Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.; RT "Diversity and diversification of HLA-A,B,C alleles."; RL J. Immunol. 142:3937-3950(1989). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*08:01). RC TISSUE=Blood; RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE B*08:01). RA Shiina S., Tamiya G., Oka A., Inoko H.; RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*08:04). RX PubMed=9331954; DOI=10.1111/j.1399-0039.1997.tb02875.x; RA Hoyer R.J., Bratlie A., Schreuder G.M., Hurley C.K.; RT "Characterization of a novel HLA-B allele, B*0804, in a Norwegian RT family."; RL Tissue Antigens 50:308-310(1997). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 33-257 (ALLELE B*08:04). RA Eberle M., Lorentzen D., Iwanaga K.K., Watkins D.I.; RT "Identification of a new HLA-B*08 variant, B*08NEW."; RL Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*08:07). RA Marcos C.Y., Lazaro A.M., Noreen H., Stastny P.; RT "New HLA-B locus allele."; RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES B*08:07 AND RP B*08:09). RX PubMed=10777103; DOI=10.1034/j.1399-0039.2000.550311.x; RA Kennedy C.T., Dodd R., Le T., Wallace R., Ng G., Greville W.D., RA Kennedy A., Taverniti A., Moses J.H., Clow N., Watson N., Dunckley H.; RT "Routine HLA-B genotyping with PCR-sequence-specific oligonucleotides RT (PCR-SSO) detects eight new alleles: B*0807, B*0809, B*1551, B*3529, RT B*3532, B*4025, B*5304 and B*5508."; RL Tissue Antigens 55:266-270(2000). RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 116-206 (ALLELE B*08:09). RX PubMed=10703615; DOI=10.1034/j.1399-0039.2000.550115.x; RA Elsner H.-A., Blasczyk R.; RT "Identification of the novel allele HLA-B*0809 in a Caucasian RT individual: estimation of allogeneic potential between B*08 RT variants."; RL Tissue Antigens 55:74-77(2000). RN [9] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES B*08:09; B*08:12; RP B*08:13 AND B*08:14). RX PubMed=11380951; DOI=10.1034/j.1399-0039.2001.057004373.x; RA Steiner N.K., Gans C.P., Kosman C., Baldassarre L.A., Edson S., RA Jones P.F., Rizzuto G., Pimtanothai N., Koester R., Mitton W., Ng J., RA Hartzman R.J., Hurley C.K.; RT "Novel HLA-B alleles associated with antigens in the 8C CREG."; RL Tissue Antigens 57:373-375(2001). RN [10] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*08:10). RA Day S.; RT "A new B*08 variant allele."; RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases. RN [11] RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 25-300. RX PubMed=8976183; DOI=10.1084/jem.184.6.2279; RA Reid S.W., McAdam S., Smith K.J., Klenerman P., O'Callaghan C.A., RA Harlos K., Jakobsen B.K., McMichael A.J., Bell J.I., Stuart D.I., RA Jones E.Y.; RT "Antagonist HIV-1 Gag peptides induce structural changes in HLA B8."; RL J. Exp. Med. 184:2279-2286(1996). RN [12] RP VARIANT [LARGE SCALE ANALYSIS] ASP-138, VARIANT [LARGE SCALE ANALYSIS] RP THR-65, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [13] RP VARIANT [LARGE SCALE ANALYSIS] SER-155, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- INTERACTION: CC Q9BX59:TAPBPL; NbExp=3; IntAct=EBI-1046513, EBI-12017416; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-8 are known: B*08:01, CC B*08:04, B*08:06, B*08:07 (B*NV), B*08:09 (B*HM; B*08HO), B*08:10, CC B*08:12, B*08:13 and B*08:14. The sequence shown is B*08:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M24036; AAA52662.1; -; Genomic_DNA. DR EMBL; AJ295294; CAC18876.1; -; Genomic_DNA. DR EMBL; BA000025; BAB63309.1; -; Genomic_DNA. DR EMBL; AH003648; AAB07726.1; -; Genomic_DNA. DR EMBL; U74386; AAB41720.1; -; mRNA. DR EMBL; AF056483; AAC14124.2; -; Genomic_DNA. DR EMBL; AF105226; AAD05244.1; -; Genomic_DNA. DR EMBL; AH007717; AAD31431.1; -; Genomic_DNA. DR EMBL; AJ131853; CAA10522.1; -; Genomic_DNA. DR EMBL; AH007613; AAD28165.1; -; Genomic_DNA. DR EMBL; AH009151; AAF36681.1; -; Genomic_DNA. DR EMBL; AH009590; AAF81604.1; -; Genomic_DNA. DR EMBL; AH009937; AAG27470.1; -; Genomic_DNA. DR EMBL; AH010664; AAK38401.1; -; Genomic_DNA. DR EMBL; AJ133101; CAB38945.1; -; Genomic_DNA. DR EMBL; AJ133102; CAB38945.1; JOINED; Genomic_DNA. DR PIR; I84431; I84431. DR UniGene; Hs.130838; -. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 1AGB; X-ray; 2.20 A; A=25-300. DR PDB; 1AGC; X-ray; 2.10 A; A=25-300. DR PDB; 1AGD; X-ray; 2.05 A; A=25-300. DR PDB; 1AGE; X-ray; 2.30 A; A=25-300. DR PDB; 1AGF; X-ray; 2.20 A; A=25-300. DR PDB; 1M05; X-ray; 1.90 A; A/C=25-301. DR PDB; 1MI5; X-ray; 2.50 A; A=25-301. DR PDB; 3FFC; X-ray; 2.80 A; A/F=25-301. DR PDB; 3SJV; X-ray; 3.10 A; A/F/K/P=25-301. DR PDB; 3SKM; X-ray; 1.80 A; A=25-300. DR PDB; 3SKO; X-ray; 1.60 A; A=25-301. DR PDB; 3SPV; X-ray; 1.30 A; A=25-300. DR PDB; 3X13; X-ray; 1.80 A; A=25-300. DR PDB; 3X14; X-ray; 2.00 A; A=25-300. DR PDB; 4QRP; X-ray; 2.90 A; A/F=25-300. DR PDB; 4QRQ; X-ray; 1.70 A; A=25-300. DR PDB; 4QRS; X-ray; 1.40 A; A=25-300. DR PDB; 4QRT; X-ray; 1.40 A; A=25-300. DR PDB; 4QRU; X-ray; 1.60 A; A=25-300. DR PDB; 5WMQ; X-ray; 1.40 A; A=25-300. DR PDB; 5WMR; X-ray; 1.58 A; A=25-300. DR PDBsum; 1AGB; -. DR PDBsum; 1AGC; -. DR PDBsum; 1AGD; -. DR PDBsum; 1AGE; -. DR PDBsum; 1AGF; -. DR PDBsum; 1M05; -. DR PDBsum; 1MI5; -. DR PDBsum; 3FFC; -. DR PDBsum; 3SJV; -. DR PDBsum; 3SKM; -. DR PDBsum; 3SKO; -. DR PDBsum; 3SPV; -. DR PDBsum; 3X13; -. DR PDBsum; 3X14; -. DR PDBsum; 4QRP; -. DR PDBsum; 4QRQ; -. DR PDBsum; 4QRS; -. DR PDBsum; 4QRT; -. DR PDBsum; 4QRU; -. DR PDBsum; 5WMQ; -. DR PDBsum; 5WMR; -. DR ProteinModelPortal; P30460; -. DR SMR; P30460; -. DR IntAct; P30460; 6. DR iPTMnet; P30460; -. DR SwissPalm; P30460; -. DR DMDM; 231381; -. DR PeptideAtlas; P30460; -. DR PRIDE; P30460; -. DR Ensembl; ENST00000425848; ENSP00000400842; ENSG00000223532. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30460; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR PhylomeDB; P30460; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR EvolutionaryTrace; P30460; -. DR GenomeRNAi; 3106; -. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB. DR GO; GO:0016020; C:membrane; HDA:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0051087; F:chaperone binding; IPI:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0046977; F:TAP binding; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-8 alpha chain. FT /FTId=PRO_0000018834. FT TOPO_DOM 25 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 4 4 M -> T (in dbSNP:rs1050458). FT /FTId=VAR_056321. FT VARIANT 9 9 V -> L (in dbSNP:rs1050462). FT /FTId=VAR_056322. FT VARIANT 17 17 L -> V (in dbSNP:rs1131165). FT /FTId=VAR_056323. FT VARIANT 48 48 S -> A (in dbSNP:rs713031). FT /FTId=VAR_061392. FT VARIANT 48 48 S -> P (in dbSNP:rs713031). FT /FTId=VAR_061393. FT VARIANT 48 48 S -> T (in dbSNP:rs713031). FT /FTId=VAR_061394. FT VARIANT 65 65 A -> T (in dbSNP:rs1050529). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056324. FT VARIANT 87 87 N -> D (in allele B*08:10; FT dbSNP:rs1050570). FT /FTId=VAR_016502. FT VARIANT 87 87 N -> K (in dbSNP:rs1065386). FT /FTId=VAR_059474. FT VARIANT 91 91 F -> S (in allele B*08:04; FT dbSNP:rs1071816). FT /FTId=VAR_016503. FT VARIANT 97 97 T -> A (in dbSNP:rs1050393). FT /FTId=VAR_056325. FT VARIANT 98 98 D -> Y (in dbSNP:rs1131215). FT /FTId=VAR_059475. FT VARIANT 101 101 S -> N (in allele B*08:06; FT dbSNP:rs1050388). FT /FTId=VAR_016504. FT VARIANT 119 119 L -> W (in allele B*08:09). FT /FTId=VAR_016505. FT VARIANT 121 121 S -> R (in allele B*08:12; FT dbSNP:rs1140412). FT /FTId=VAR_016506. FT VARIANT 121 121 S -> T (in allele B*08:09; FT dbSNP:rs1071652). FT /FTId=VAR_016507. FT VARIANT 137 138 HN -> YH (in allele B*08:14). FT /FTId=VAR_016519. FT VARIANT 137 137 H -> Y (in dbSNP:rs1050379). FT /FTId=VAR_056326. FT VARIANT 138 138 N -> D (in allele B*08:07; FT dbSNP:rs709055). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_016508. FT VARIANT 140 140 Y -> D (in allele B*08:14; FT dbSNP:rs9266150). FT /FTId=VAR_016520. FT VARIANT 155 155 R -> S (in dbSNP:rs1050654). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_056327. FT VARIANT 176 176 V -> E (in allele B*08:06; FT dbSNP:rs151341293). FT /FTId=VAR_016509. FT VARIANT 180 180 D -> L (in allele B*08:13; requires 2 FT nucleotide substitutions). FT /FTId=VAR_016510. FT VARIANT 180 180 D -> R (in allele B*08:06; requires 2 FT nucleotide substitutions; FT dbSNP:rs376871308). FT /FTId=VAR_016511. FT VARIANT 306 306 V -> I (in dbSNP:rs1131500). FT /FTId=VAR_056328. FT VARIANT 329 329 A -> T (in dbSNP:rs1051488). FT /FTId=VAR_056329. FT VARIANT 349 349 C -> S (in dbSNP:rs2308655). FT /FTId=VAR_061395. FT VARIANT 349 349 C -> Y (in dbSNP:rs2308655). FT /FTId=VAR_061396. FT STRAND 27 36 {ECO:0000244|PDB:3SPV}. FT STRAND 41 43 {ECO:0000244|PDB:3SPV}. FT STRAND 45 52 {ECO:0000244|PDB:3SPV}. FT STRAND 55 61 {ECO:0000244|PDB:3SPV}. FT STRAND 65 70 {ECO:0000244|PDB:3SPV}. FT HELIX 74 77 {ECO:0000244|PDB:3SPV}. FT HELIX 81 108 {ECO:0000244|PDB:3SPV}. FT STRAND 113 115 {ECO:0000244|PDB:4QRS}. FT STRAND 118 127 {ECO:0000244|PDB:3SPV}. FT STRAND 129 131 {ECO:0000244|PDB:4QRP}. FT STRAND 133 142 {ECO:0000244|PDB:3SPV}. FT STRAND 145 150 {ECO:0000244|PDB:3SPV}. FT STRAND 157 161 {ECO:0000244|PDB:3SPV}. FT HELIX 162 173 {ECO:0000244|PDB:3SPV}. FT HELIX 176 185 {ECO:0000244|PDB:3SPV}. FT HELIX 187 198 {ECO:0000244|PDB:3SPV}. FT HELIX 200 203 {ECO:0000244|PDB:3SPV}. FT STRAND 210 217 {ECO:0000244|PDB:3SPV}. FT STRAND 219 235 {ECO:0000244|PDB:3SPV}. FT STRAND 238 243 {ECO:0000244|PDB:3SPV}. FT HELIX 249 251 {ECO:0000244|PDB:3SPV}. FT STRAND 252 254 {ECO:0000244|PDB:4QRU}. FT STRAND 261 263 {ECO:0000244|PDB:3SPV}. FT STRAND 265 274 {ECO:0000244|PDB:3SPV}. FT STRAND 275 277 {ECO:0000244|PDB:3SJV}. FT HELIX 278 280 {ECO:0000244|PDB:3SPV}. FT STRAND 281 286 {ECO:0000244|PDB:3SPV}. FT STRAND 290 292 {ECO:0000244|PDB:3SKO}. FT STRAND 294 296 {ECO:0000244|PDB:3SPV}. SQ SEQUENCE 362 AA; 40331 MW; 9B2A9760021680DF CRC64; MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFDTAMSRPG RGEPRFISVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI FKTNTQTDRE SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARVAEQD RAYLEGTCVE WLRRYLENGK DTLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA // ID 1B13_HUMAN Reviewed; 362 AA. AC P30461; O02956; O78180; Q29661; Q29933; Q9GIY5; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 146. DE RecName: Full=HLA class I histocompatibility antigen, B-13 alpha chain; DE AltName: Full=MHC class I antigen B*13; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE B*13:02). RX PubMed=2715640; RA Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.; RT "Diversity and diversification of HLA-A,B,C alleles."; RL J. Immunol. 142:3937-3950(1989). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*13:02). RX PubMed=3257938; DOI=10.1007/BF00376123; RA Zemmour J., Ennis P.D., Parham P., Dupont B.; RT "Comparison of the structure of HLA-Bw47 to HLA-B13 and its RT relationship to 21-hydroxylase deficiency."; RL Immunogenetics 27:281-287(1988). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*13:01). RX PubMed=2914710; DOI=10.1007/BF00395860; RA Kato K., Dupont B., Yang S.Y.; RT "Localization of nucleotide sequence which determines Mongoloid RT subtype of HLA-B13."; RL Immunogenetics 29:117-120(1989). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*13:01 AND B*13:02). RC TISSUE=Blood; RX PubMed=7558929; DOI=10.1016/0198-8859(94)00120-F; RA Lin L., Tokunaga K., Nakajima F., Ishikawa Y., Kashiwase K., RA Tanaka H., Kuwata S., Sideltseva E., Akaza T., Tadokoro K., RA Shibata Y., Chandanayingyong D., Juji T.; RT "Both HLA-B*1301 and B*1302 exist in Asian populations and are RT associated with different haplotypes."; RL Hum. Immunol. 43:51-56(1995). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*13:03). RC TISSUE=Blood; RX PubMed=8655357; DOI=10.1016/0198-8859(95)00143-3; RA Balas A., Garcia-Sanchez F., Vicario J.L.; RT "HLA-B*1303: a new example of poor correlation between serology and RT structure."; RL Hum. Immunol. 45:32-36(1996). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*13:04). RX PubMed=9328792; DOI=10.1016/S0198-8859(97)00055-4; RA Ellexson M., Lai-Kwan P., Lau M., Muto K., Terasaki P., Cole J., RA Thompson C., Hildebrand W.H.; RT "Polymorphism at codons 114, 116, 145, and 163 muddle the typing of RT HLA-B1304."; RL Hum. Immunol. 55:66-73(1997). RN [7] RP NUCLEOTIDE SEQUENCE (ALLELE B*13:08). RA Carter V., Dunn P.P.; RT "Identification of a HLA-B*13 null allele."; RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases. RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [10] RP VARIANT [LARGE SCALE ANALYSIS] ARG-169, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-13 are known: B*13:01 CC (B13.1), B*13:02 (B13.2), B*13:04 and B*13:08. The sequence shown CC is that of B*13:02. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M24041; AAA59660.1; -; Genomic_DNA. DR EMBL; M19757; AAA52657.1; -; Genomic_DNA. DR EMBL; M24075; AAA59627.1; -; Genomic_DNA. DR EMBL; D50290; BAA08821.1; -; mRNA. DR EMBL; D50291; BAA08822.1; -; mRNA. DR EMBL; U14943; AAB06829.1; -; mRNA. DR EMBL; U75533; AAC31793.1; -; mRNA. DR EMBL; AJ295279; CAC17137.1; -; Genomic_DNA. DR PIR; A45850; A45850. DR PIR; I54442; I54442. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; P30461; -. DR SMR; P30461; -. DR IntAct; P30461; 1. DR MINT; P30461; -. DR SwissPalm; P30461; -. DR DMDM; 231382; -. DR MaxQB; P30461; -. DR PeptideAtlas; P30461; -. DR PRIDE; P30461; -. DR Ensembl; ENST00000435618; ENSP00000405178; ENSG00000224608. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30461; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-13 alpha chain. FT /FTId=PRO_0000018835. FT TOPO_DOM 25 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 118 119 TW -> II (in allele B*13:01). FT /FTId=VAR_016357. FT VARIANT 121 121 T -> R (in allele B*13:01). FT /FTId=VAR_016358. FT VARIANT 138 138 N -> D (in allele B*13:04). FT /FTId=VAR_016360. FT VARIANT 140 140 L -> S (in allele B*13:04). FT /FTId=VAR_016361. FT VARIANT 169 169 L -> R (in allele B*13:03 and allele FT B*13:04; requires 2 nucleotide FT substitutions). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_016362. FT VARIANT 183 183 Y -> C (in allele B*13:08). FT /FTId=VAR_016359. FT VARIANT 187 187 E -> L (in allele B*13:03 and allele FT B*13:04; requires 2 nucleotide FT substitutions). FT /FTId=VAR_016363. FT VARIANT 306 306 V -> I (in dbSNP:rs1131500). FT /FTId=VAR_056330. FT VARIANT 329 329 A -> T (in dbSNP:rs1051488). FT /FTId=VAR_056331. FT VARIANT 349 349 C -> S (in dbSNP:rs2308655). FT /FTId=VAR_061397. FT VARIANT 349 349 C -> Y (in dbSNP:rs2308655). FT /FTId=VAR_061398. SQ SEQUENCE 362 AA; 40474 MW; 28FF66B20961C75C CRC64; MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFITVG YVDDTQFVRF DSDATSPRMA PRAPWIEQEG PEYWDRETQI SKTNTQTYRE NLRTALRYYN QSEAGSHTWQ TMYGCDLGPD GRLLRGHNQL AYDGKDYIAL NEDLSSWTAA DTAAQITQLK WEAARVAEQL RAYLEGECVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA // ID 1B14_HUMAN Reviewed; 362 AA. AC P30462; O02862; P30463; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 143. DE RecName: Full=HLA class I histocompatibility antigen, B-14 alpha chain; DE AltName: Full=MHC class I antigen B*14; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES B*14:01 AND B*14:02). RX PubMed=2715640; RA Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.; RT "Diversity and diversification of HLA-A,B,C alleles."; RL J. Immunol. 142:3937-3950(1989). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*14:02). RC TISSUE=Blood; RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*14:03). RX PubMed=11098929; DOI=10.1034/j.1399-0039.2000.560401.x; RA Ellis J.M., Mack S.J., Leke R.F.G., Quakyi I., Johnson A.H., RA Hurley C.K.; RT "Diversity is demonstrated in class I HLA-A and HLA-B alleles in RT Cameroon, Africa: description of HLA-A*03012, *2612, *3006 and HLA- RT B*1403, *4016, *4703."; RL Tissue Antigens 56:291-302(2000). RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] RP VARIANT [LARGE SCALE ANALYSIS] THR-65, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-14 are known: B*14:01 CC (Bw-64; B-64), B*14:02 (Bw-65, B-65) and B*14:03. The sequence CC shown is that of B*14:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M24040; AAA59661.1; -; Genomic_DNA. DR EMBL; M24032; AAA59664.1; -; Genomic_DNA. DR EMBL; AJ301657; CAC20461.1; -; Genomic_DNA. DR EMBL; AH005448; AAB61335.1; -; Genomic_DNA. DR PIR; I61859; I61859. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; P30462; -. DR SMR; P30462; -. DR SwissPalm; P30462; -. DR EPD; P30462; -. DR MaxQB; P30462; -. DR PeptideAtlas; P30462; -. DR PRIDE; P30462; -. DR Ensembl; ENST00000425848; ENSP00000400842; ENSG00000223532. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30462; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0046977; F:TAP binding; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-14 alpha chain. FT /FTId=PRO_0000018836. FT TOPO_DOM 25 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 4 4 M -> T (in dbSNP:rs1050458). FT /FTId=VAR_056332. FT VARIANT 9 9 V -> L (in dbSNP:rs1050462). FT /FTId=VAR_056333. FT VARIANT 17 17 L -> V (in dbSNP:rs1131165). FT /FTId=VAR_056334. FT VARIANT 35 35 S -> A (in allele B*14:02 and allele FT B*14:03; dbSNP:rs1131170). FT /FTId=VAR_016364. FT VARIANT 36 36 V -> M (in dbSNP:rs1050486). FT /FTId=VAR_056335. FT VARIANT 48 48 S -> A (in dbSNP:rs713031). FT /FTId=VAR_061399. FT VARIANT 48 48 S -> P (in dbSNP:rs713031). FT /FTId=VAR_061400. FT VARIANT 48 48 S -> T (in dbSNP:rs713031). FT /FTId=VAR_061401. FT VARIANT 65 65 A -> T (in dbSNP:rs1050529). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056336. FT VARIANT 87 87 N -> D (in dbSNP:rs1050570). FT /FTId=VAR_056337. FT VARIANT 87 87 N -> K (in dbSNP:rs1065386). FT /FTId=VAR_059476. FT VARIANT 97 97 T -> A (in dbSNP:rs1050393). FT /FTId=VAR_056338. FT VARIANT 98 98 D -> Y (in dbSNP:rs1131215). FT /FTId=VAR_059477. FT VARIANT 180 180 L -> R (in allele B*14:03). FT /FTId=VAR_016654. FT VARIANT 306 306 V -> I (in dbSNP:rs1131500). FT /FTId=VAR_056339. FT VARIANT 329 329 A -> T (in dbSNP:rs1051488). FT /FTId=VAR_056340. SQ SEQUENCE 362 AA; 40358 MW; 9039122CC400337F CRC64; MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI CKTNTQTDRE SLRNLRGYYN QSEAGSHTLQ WMYGCDVGPD GRLLRGYNQF AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQL RAYLEGTCVE WLRRHLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B15_HUMAN Reviewed; 362 AA. AC P30464; B0V0B8; P30465; P30513; Q29633; Q29636; Q29829; Q29953; AC Q29982; Q95343; Q95344; Q9BD06; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 22-AUG-2003, sequence version 2. DT 12-SEP-2018, entry version 164. DE RecName: Full=HLA class I histocompatibility antigen, B-15 alpha chain; DE AltName: Full=MHC class I antigen B*15; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*15:02). RX PubMed=1801311; DOI=10.1111/j.1399-0039.1991.tb01895.x; RA Little A.-M., Parham P.; RT "The HLA-Bw75 subtype of B15: molecular characterization and RT comparison with crossreacting antigens."; RL Tissue Antigens 38:186-190(1991). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*15:01; B*15:11 AND B*15:19). RX PubMed=7521976; DOI=10.1111/j.1399-0039.1994.tb02327.x; RA Hildebrand W.H., Domena J.D., Shen S.Y., Lau M., Terasaki P.I., RA Bunce M., Marsh S.G.E., Guttridge M.G., Bias W.B., Parham P.; RT "HLA-B15: a widespread and diverse family of HLA-B alleles."; RL Tissue Antigens 43:209-218(1994). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*15:01; B*15:02 AND B*15:11). RC TISSUE=Blood; RX PubMed=8773315; DOI=10.1111/j.1399-0039.1996.tb02553.x; RA Lin L., Tokunaga K., Tanaka H., Nakajima F., Imanishi T., RA Kashiwase K., Bannai M., Mizuno S., Akaza T., Tadokoro K., Shibata Y., RA Juji T.; RT "Further molecular diversity in the HLA-B15 group."; RL Tissue Antigens 47:265-274(1996). RN [4] RP NUCLEOTIDE SEQUENCE (ALLELE B*15:03). RX PubMed=1431115; RA Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J., RA Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., RA Martell R.W., du Toit E.D., Parham P.; RT "Distinctive HLA-A,B antigens of black populations formed by RT interallelic conversion."; RL J. Immunol. 149:3411-3415(1992). RN [5] RP NUCLEOTIDE SEQUENCE (ALLELE B*15:04). RX PubMed=1589035; DOI=10.1038/357329a0; RA Watkins D.I., McAdam S.N., Liu X., Stang C.R., Milford E.L., RA Levine C.G., Garber T.L., Dogon A.L., Lord C.I., Ghim S.H., RA Troup G.M., Hughes A.L., Letvin N.L.; RT "New recombinant HLA-B alleles in a tribe of South American RT Amerindians indicate rapid evolution of MHC class I loci."; RL Nature 357:329-333(1992). RN [6] RP NUCLEOTIDE SEQUENCE (ALLELE B*15:04). RC TISSUE=Blood; RA Ramos M., Barber D.F., Layrisse Z., de Castro J.A.; RL Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE (ALLELE B*15:01). RC TISSUE=Blood; RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [8] RP NUCLEOTIDE SEQUENCE (ALLELE B*15:66). RX PubMed=12144628; DOI=10.1034/j.1399-0039.2002.590511.x; RA Cox S.T., Prokupek B., Baker F., Holman R., Leung V.T., Wong A.S., RA Madrigal J.A., Little A.-M.; RT "Identification of HLA-B*1566."; RL Tissue Antigens 59:424-425(2002). RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [10] RP NUCLEOTIDE SEQUENCE [MRNA] OF 5-362 (ALLELE B*15:01). RX PubMed=2714852; DOI=10.1007/BF00352839; RA Pohla H., Kuon W., Tabaczewski P., Doerner C., Weiss E.H.; RT "Allelic variation in HLA-B and HLA-C sequences and the evolution of RT the HLA-B alleles."; RL Immunogenetics 29:297-307(1989). RN [11] RP NUCLEOTIDE SEQUENCE [MRNA] OF 25-362 (ALLELE B*15:01). RX PubMed=8423049; DOI=10.1007/BF00216833; RA Choo S.Y., Fan L.A., Hansen J.A.; RT "Allelic variations clustered in the antigen binding sites of HLA-Bw62 RT molecules."; RL Immunogenetics 37:108-113(1993). RN [12] RP ASSOCIATION OF ALLELE B*15:02 WITH STEVENS-JOHNSON SYNDROME. RX PubMed=15057820; DOI=10.1038/428486a; RA Chung W.-H., Hung S.-I., Hong H.-S., Hsih M.-S., Yang L.-C., Ho H.-C., RA Wu J.-Y., Chen Y.-T.; RT "Medical genetics: a marker for Stevens-Johnson syndrome."; RL Nature 428:486-486(2004). RN [13] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [14] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [15] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [16] RP X-RAY CRYSTALLOGRAPHY (1.79 ANGSTROMS) OF 25-300 (ALLELE B*15:01) IN RP COMPLEX WITH EBV NUCLEAR ANTIGEN AND UBE2 PEPTIDES, AND DISULFIDE RP BONDS. RX PubMed=17057332; DOI=10.1107/S0907444906027636; RA Roder G., Blicher T., Justesen S., Johannesen B., Kristensen O., RA Kastrup J., Buus S., Gajhede M.; RT "Crystal structures of two peptide-HLA-B*1501 complexes; structural RT characterization of the HLA-B62 supertype."; RL Acta Crystallogr. D 62:1300-1310(2006). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-15 are known: B*15:01 CC (Bw-62; B-62), B*15:02 (Bw-75, B-75), B*15:03 (Bw-72; B-72; B-70) CC B*15:04, B*15:11, B*15:19 and B*15:66. The sequence shown is that CC of B*15:01. CC -!- DISEASE: Stevens-Johnson syndrome (SJS) [MIM:608579]: A rare CC blistering mucocutaneous disease that share clinical and CC histopathologic features with toxic epidermal necrolysis. Both CC disorders are characterized by high fever, malaise, and a rapidly CC developing blistering exanthema of macules and target-like lesions CC accompanied by mucosal involvement. Stevens-Johnson syndrome is a CC milder disease characterized by destruction and detachment of the CC skin epithelium and mucous membranes involving less than 10% of CC the body surface area. Ocular symptoms include ulcerative CC conjunctivitis, keratitis, iritis, uveitis and sometimes CC blindness. It can be caused by a severe adverse reaction to CC particular types of medication, although Mycoplasma infections may CC induce some cases. Note=Disease susceptibility is associated with CC variations affecting the gene represented in this entry. Increased CC susceptibility to Stevens-Johnson syndrome is conferred by allele CC B*15:02. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M75138; AAA59630.1; -; mRNA. DR EMBL; U03859; AAA03601.1; -; mRNA. DR EMBL; U03027; AAA18902.1; -; mRNA. DR EMBL; L11604; AAA56836.1; -; mRNA. DR EMBL; D50292; BAA08823.1; -; mRNA. DR EMBL; D50293; BAA08824.1; -; mRNA. DR EMBL; D50294; BAA08825.1; -; mRNA. DR EMBL; X61709; CAA43878.1; -; mRNA. DR EMBL; M84382; AAA59632.1; -; mRNA. DR EMBL; U70528; AAB16918.1; -; mRNA. DR EMBL; AJ295140; CAC17462.1; -; Genomic_DNA. DR EMBL; AJ308399; CAC33441.1; -; Genomic_DNA. DR EMBL; CR759828; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; M28203; AAA53258.1; -; mRNA. DR EMBL; M83193; AAA58628.1; -; mRNA. DR PIR; G01230; G01230. DR PIR; I38421; I38421. DR PIR; I62042; I62042. DR PIR; S16789; S16789. DR PIR; S24433; S24433. DR PIR; S77966; S77966. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 1XR8; X-ray; 2.30 A; A=25-300. DR PDB; 1XR9; X-ray; 1.79 A; A=25-300. DR PDB; 3C9N; X-ray; 1.87 A; A=25-300. DR PDB; 5TXS; X-ray; 1.70 A; A=25-304. DR PDB; 5VZ5; X-ray; 2.59 A; A=25-304. DR PDBsum; 1XR8; -. DR PDBsum; 1XR9; -. DR PDBsum; 3C9N; -. DR PDBsum; 5TXS; -. DR PDBsum; 5VZ5; -. DR ProteinModelPortal; P30464; -. DR SMR; P30464; -. DR IntAct; P30464; 2. DR SwissPalm; P30464; -. DR DMDM; 34305703; -. DR EPD; P30464; -. DR MaxQB; P30464; -. DR PeptideAtlas; P30464; -. DR PRIDE; P30464; -. DR Ensembl; ENST00000450871; ENSP00000388208; ENSG00000232126. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR MIM; 608579; phenotype. DR neXtProt; NX_P30464; -. DR Orphanet; 240841; Abacavir toxicity. DR Orphanet; 240845; Allopurinol toxicity. DR Orphanet; 825; Ankylosing spondylitis. DR Orphanet; 117; Behcet disease. DR Orphanet; 240871; Flucloxacilline toxicity. DR Orphanet; 414750; Phenytoin or carbamazepine toxicity. DR Orphanet; 275798; Pulmonary arterial hypertension associated with connective tissue disease. DR Orphanet; 36426; Stevens-Johnson syndrome. DR Orphanet; 3287; Takayasu arteritis. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR PhylomeDB; P30464; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR EvolutionaryTrace; P30464; -. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-15 alpha chain. FT /FTId=PRO_0000018837. FT TOPO_DOM 25 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:17057332}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:17057332}. FT VARIANT 48 48 A -> S (in allele B*15:03; FT dbSNP:rs713031). FT /FTId=VAR_016365. FT VARIANT 69 70 MA -> EE (in allele B*15:03). FT /FTId=VAR_016366. FT VARIANT 87 87 E -> N (in allele B*15:02 and allele FT B*15:11; requires 2 nucleotide FT substitutions). FT /FTId=VAR_016367. FT VARIANT 91 91 S -> C (in allele B*15:66; FT dbSNP:rs1071816). FT /FTId=VAR_016368. FT VARIANT 91 91 S -> Y (in allele B*15:11; FT dbSNP:rs1071816). FT /FTId=VAR_016369. FT VARIANT 118 119 TL -> II (in allele B*15:02; FT dbSNP:rs796332753). FT /FTId=VAR_016370. FT VARIANT 119 119 L -> W (in allele B*15:04; FT dbSNP:rs41556312). FT /FTId=VAR_016371. FT VARIANT 121 121 R -> T (in allele B*15:04; FT dbSNP:rs1071652). FT /FTId=VAR_016372. FT VARIANT 137 137 H -> Y (in allele B*15:02; FT dbSNP:rs1050379). FT /FTId=VAR_016373. FT VARIANT 180 180 W -> L (in allele B*15:02 and allele FT B*15:03; dbSNP:rs697742). FT /FTId=VAR_016374. FT VARIANT 190 191 EW -> DG (in allele B*15:19). FT /FTId=VAR_016375. FT VARIANT 274 274 P -> L (in allele B*15:19; FT dbSNP:rs41545517). FT /FTId=VAR_016376. FT STRAND 27 36 {ECO:0000244|PDB:5TXS}. FT STRAND 41 43 {ECO:0000244|PDB:5TXS}. FT STRAND 45 52 {ECO:0000244|PDB:5TXS}. FT STRAND 55 61 {ECO:0000244|PDB:5TXS}. FT STRAND 64 66 {ECO:0000244|PDB:5TXS}. FT HELIX 74 76 {ECO:0000244|PDB:5TXS}. FT HELIX 81 108 {ECO:0000244|PDB:5TXS}. FT STRAND 118 127 {ECO:0000244|PDB:5TXS}. FT STRAND 133 142 {ECO:0000244|PDB:5TXS}. FT STRAND 145 150 {ECO:0000244|PDB:5TXS}. FT STRAND 157 161 {ECO:0000244|PDB:5TXS}. FT HELIX 162 173 {ECO:0000244|PDB:5TXS}. FT HELIX 176 185 {ECO:0000244|PDB:5TXS}. FT HELIX 187 198 {ECO:0000244|PDB:5TXS}. FT HELIX 200 203 {ECO:0000244|PDB:5TXS}. FT STRAND 210 217 {ECO:0000244|PDB:5TXS}. FT STRAND 219 235 {ECO:0000244|PDB:5TXS}. FT STRAND 238 243 {ECO:0000244|PDB:5TXS}. FT HELIX 249 251 {ECO:0000244|PDB:5TXS}. FT STRAND 261 263 {ECO:0000244|PDB:5TXS}. FT STRAND 265 274 {ECO:0000244|PDB:5TXS}. FT HELIX 278 280 {ECO:0000244|PDB:5TXS}. FT STRAND 281 286 {ECO:0000244|PDB:5TXS}. FT STRAND 290 292 {ECO:0000244|PDB:1XR9}. FT STRAND 294 296 {ECO:0000244|PDB:5TXS}. SQ SEQUENCE 362 AA; 40388 MW; 86E938087372EBE0 CRC64; MRVTAPRTVL LLLSGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRMA PRAPWIEQEG PEYWDRETQI SKTNTQTYRE SLRNLRGYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHDQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQW RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B18_HUMAN Reviewed; 362 AA. AC P30466; O62897; Q29845; Q5JP37; Q9BCM6; Q9GJ23; Q9MY84; Q9MYC7; AC Q9TP37; Q9TQH7; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 156. DE RecName: Full=HLA class I histocompatibility antigen, B-18 alpha chain; DE AltName: Full=MHC class I antigen B*18; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE B*18:01). RX PubMed=2715640; RA Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.; RT "Diversity and diversification of HLA-A,B,C alleles."; RL J. Immunol. 142:3937-3950(1989). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*18:02). RC TISSUE=Blood; RX PubMed=7751157; DOI=10.1016/0198-8859(94)00073-Y; RA Lin L., Tokunaga K., Ishikawa Y., Kashiwase K., Nakajima F., RA Nishimura M., Kuwata S., Akaza T., Tadokoro K., Shibata Y., Juji T.; RT "A new B18 sequence (B*1802) from Asian individuals."; RL Hum. Immunol. 42:23-26(1995). RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE B*18:01). RC TISSUE=Blood; RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [4] RP NUCLEOTIDE SEQUENCE (ALLELE B*18:03). RA Dunn P.P.J.; RT "Complete nucleotide sequencing of HLA class I genes."; RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [6] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*18:07). RA Kennedy C.T., Dodd R., Le T., Wallace R., Ng G., Hersee J., RA Taverniti A., Kennedy A., Moses J., Trejaut J., Dunckley H.; RT "HLA-B typing with sequence specific oligonucleotides reveals a new RT allele, B*MF."; RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES B*18:07; B*18:10; RP B*18:11; B*18:12 AND B*18:13). RX PubMed=11556976; DOI=10.1034/j.1399-0039.2001.057005481.x; RA Steiner N.K., Kosman C., Jones P.F., Gans C.P., Rodriguez-Marino S.G., RA Rizzuto G., Baldassarre L.A., Edson S., Koester R., Sese D., RA Mitton W., Ng J., Hartzman R.J., Hurley C.K.; RT "Twenty-nine new HLA-B alleles associated with antigens in the 5C RT CREG."; RL Tissue Antigens 57:481-485(2001). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [10] RP VARIANT [LARGE SCALE ANALYSIS] GLU-87, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-18 are known: B*18:01 CC B*18:02, B*18:03, B*18:07 (B*MF), B*18:10, B*18:11, B*18:12 and CC B*18:13. The sequence shown is that of B*18:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M24039; AAA59662.1; -; Genomic_DNA. DR EMBL; D25275; BAA04965.1; -; mRNA. DR EMBL; AJ310507; CAC34572.1; -; Genomic_DNA. DR EMBL; AJ309979; CAC34305.1; -; Genomic_DNA. DR EMBL; AL845443; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AH007328; AAD13298.1; -; Genomic_DNA. DR EMBL; AF054010; AAC32821.1; -; Genomic_DNA. DR EMBL; AF054009; AAC32821.1; JOINED; Genomic_DNA. DR EMBL; AH008878; AAF20813.1; -; Genomic_DNA. DR EMBL; AH009390; AAF73066.1; -; Genomic_DNA. DR EMBL; AH009624; AAF85974.1; -; Genomic_DNA. DR EMBL; AF310139; AAG27466.1; -; Genomic_DNA. DR EMBL; AF310138; AAG27466.1; JOINED; Genomic_DNA. DR PIR; I61860; I61860. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 4JQV; X-ray; 1.50 A; A=25-302. DR PDB; 4XXC; X-ray; 1.43 A; A=25-303. DR PDBsum; 4JQV; -. DR PDBsum; 4XXC; -. DR ProteinModelPortal; P30466; -. DR SMR; P30466; -. DR BioGrid; 109351; 108. DR iPTMnet; P30466; -. DR SwissPalm; P30466; -. DR DMDM; 231388; -. DR PeptideAtlas; P30466; -. DR PRIDE; P30466; -. DR Ensembl; ENST00000359635; ENSP00000352656; ENSG00000206450. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30466; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR PhylomeDB; P30466; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0016020; C:membrane; HDA:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-18 alpha chain. FT /FTId=PRO_0000018838. FT TOPO_DOM 25 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 87 87 N -> E (in allele B*18:12; requires 2 FT nucleotide substitutions). FT {ECO:0000244|PubMed:24275569}. FT /FTId=VAR_016661. FT VARIANT 91 91 S -> F (in allele B*18:07; FT dbSNP:rs1071816). FT /FTId=VAR_016662. FT VARIANT 98 98 Y -> D (in allele B*18:03; FT dbSNP:rs1131215). FT /FTId=VAR_016377. FT VARIANT 121 121 R -> N (in allele B*18:02; requires 2 FT nucleotide substitutions). FT /FTId=VAR_016378. FT VARIANT 180 180 L -> R (in allele B*18:13; FT dbSNP:rs697742). FT /FTId=VAR_016663. FT VARIANT 187 187 T -> E (in allele B*18:10; requires 2 FT nucleotide substitutions; FT dbSNP:rs796093434). FT /FTId=VAR_016664. FT VARIANT 195 195 H -> Y (in allele B*18:10 and allele FT B*18:11; dbSNP:rs1050696). FT /FTId=VAR_016665. FT STRAND 27 36 {ECO:0000244|PDB:4XXC}. FT STRAND 45 52 {ECO:0000244|PDB:4XXC}. FT STRAND 55 61 {ECO:0000244|PDB:4XXC}. FT STRAND 64 66 {ECO:0000244|PDB:4XXC}. FT HELIX 74 76 {ECO:0000244|PDB:4XXC}. FT HELIX 81 108 {ECO:0000244|PDB:4XXC}. FT STRAND 118 127 {ECO:0000244|PDB:4XXC}. FT STRAND 133 142 {ECO:0000244|PDB:4XXC}. FT STRAND 145 150 {ECO:0000244|PDB:4XXC}. FT STRAND 157 161 {ECO:0000244|PDB:4XXC}. FT HELIX 162 173 {ECO:0000244|PDB:4XXC}. FT HELIX 176 185 {ECO:0000244|PDB:4XXC}. FT HELIX 187 198 {ECO:0000244|PDB:4XXC}. FT HELIX 200 203 {ECO:0000244|PDB:4XXC}. FT STRAND 210 235 {ECO:0000244|PDB:4XXC}. FT STRAND 238 243 {ECO:0000244|PDB:4XXC}. FT TURN 249 251 {ECO:0000244|PDB:4XXC}. FT STRAND 261 263 {ECO:0000244|PDB:4XXC}. FT STRAND 265 274 {ECO:0000244|PDB:4XXC}. FT HELIX 278 280 {ECO:0000244|PDB:4XXC}. FT STRAND 281 286 {ECO:0000244|PDB:4XXC}. FT STRAND 290 292 {ECO:0000244|PDB:4JQV}. FT STRAND 294 296 {ECO:0000244|PDB:4XXC}. SQ SEQUENCE 362 AA; 40275 MW; 106552F4A0F28E17 CRC64; MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFHTSVSRPG RGEPRFISVG YVDGTQFVRF DSDAASPRTE PRAPWIEQEG PEYWDRNTQI SKTNTQTYRE SLRNLRGYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHDQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRHLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B27_HUMAN Reviewed; 362 AA. AC P03989; O19692; P10317; P10318; P19373; P30467; Q08136; Q29693; AC Q29846; Q29961; DT 23-OCT-1986, integrated into UniProtKB/Swiss-Prot. DT 13-AUG-1987, sequence version 2. DT 12-SEP-2018, entry version 186. DE RecName: Full=HLA class I histocompatibility antigen, B-27 alpha chain; DE AltName: Full=MHC class I antigen B*27; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*27:01). RX PubMed=3912316; RA Weiss E.H., Kuon W., Doerner C., Lang M., Riethmueller G.; RT "Organization, sequence and expression of the HLA-B27 gene: a RT molecular approach to analyze HLA and disease associations."; RL Immunobiology 170:367-380(1985). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 25-361 (ALLELE B*27:01). RX PubMed=3485286; DOI=10.1073/pnas.83.5.1428; RA Szoets H., Riethmueller G., Weiss E., Meo T.; RT "Complete sequence of HLA-B27 cDNA identified through the RT characterization of structural markers unique to the HLA-A, -B, and -C RT allelic series."; RL Proc. Natl. Acad. Sci. U.S.A. 83:1428-1432(1986). RN [3] RP PROTEIN SEQUENCE OF 25-295 (B*27:01). RX PubMed=2408663; DOI=10.1021/bi00328a025; RA Ezquerra A., Bragado R., Vega M.A., Strominger J.L., Woody J., RA Lopez de Castro J.A.; RT "Primary structure of papain-solubilized human histocompatibility RT antigen HLA-B27."; RL Biochemistry 24:1733-1741(1985). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES B*27:01 AND B*27:02). RX PubMed=3011411; RA Seemann G.H.A., Rein R.S., Brown C.S., Ploegh H.L.; RT "Gene conversion-like mechanisms may generate polymorphism in human RT class I genes."; RL EMBO J. 5:547-552(1986). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*27:02). RX PubMed=7482496; DOI=10.1111/j.1399-0039.1995.tb02475.x; RA Moses J.H., Marsh S.G.E., Arnett K.L., Adams E.J., Bodmer J.G., RA Parham P.; RT "On the nucleotide sequences of B*2702 and B*2705."; RL Tissue Antigens 46:50-53(1995). RN [6] RP PROTEIN SEQUENCE OF 86-107 AND 171-181 (B*27:02). RX PubMed=2414775; DOI=10.1073/pnas.82.21.7394; RA Vega M.A., Ezquerra A., Rojo S., Aparicio P., Bragado R., RA Lopez de Castro J.A.; RT "Structural analysis of an HLA-B27 functional variant: identification RT of residues that contribute to the specificity of recognition by RT cytolytic T lymphocytes."; RL Proc. Natl. Acad. Sci. U.S.A. 82:7394-7398(1985). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*27:03). RX PubMed=3286582; DOI=10.1016/0198-8859(88)90072-9; RA Choo S.Y., St John T., Orr H.T., Hansen J.A.; RT "Molecular analysis of the variant alloantigen HLA-B27d (HLA-B*2703) RT identifies a unique single amino acid substitution."; RL Hum. Immunol. 21:209-219(1988). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*27:04 AND B*27:06). RX PubMed=8550101; DOI=10.1007/BF00176678; RA Rudwaleit M., Bowness P., Wordsworth P.; RT "The nucleotide sequence of HLA-B*2704 reveals a new amino acid RT substitution in exon 4 which is also present in HLA-B*2706."; RL Immunogenetics 43:160-162(1996). RN [9] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-298 (ALLELE B*27:05). RX PubMed=3489755; RA Coppin H.L., McDevitt H.O.; RT "Absence of polymorphism between HLA-B27 genomic exon sequences RT isolated from normal donors and ankylosing spondylitis patients."; RL J. Immunol. 137:2168-2172(1986). RN [10] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*27:06). RX PubMed=8276469; DOI=10.1007/BF00241265; RA Vilches C., de Pablo R., Kreisler M.; RT "Nucleotide sequence of HLA-B*2706."; RL Immunogenetics 39:219-219(1994). RN [11] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*27:07). RX PubMed=1711072; RA Choo Y.S., Fan L.A., Hansen J.A.; RT "A novel HLA-B27 allele maps B27 allospecificity to the region around RT position 70 in the alpha 1 domain."; RL J. Immunol. 147:174-180(1991). RN [12] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*27:08). RX PubMed=7974468; DOI=10.1111/j.1399-0039.1994.tb02356.x; RA Hildebrand W.H., Domena J.D., Shen S.Y., Marsh S.G.E., Bunce M., RA Guttridge M.G., Darke C., Parham P.; RT "The HLA-B7Qui antigen is encoded by a new subtype of HLA-B27 RT (B*2708)."; RL Tissue Antigens 44:47-51(1994). RN [13] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*27:09). RC TISSUE=Blood; RX PubMed=8089488; RA Del Porto P., D'Amato M., Fiorillo M.T., Tuosto L., Piccolella E., RA Sorrentino R.; RT "Identification of a novel HLA-B27 subtype by restriction analysis of RT a cytotoxic gamma/delta T cell clone."; RL J. Immunol. 153:3093-3100(1994). RN [14] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110. RC TISSUE=Liver; RX PubMed=19159218; DOI=10.1021/pr8008012; RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; RT "Glycoproteomics analysis of human liver tissue by combination of RT multiple enzyme digestion and hydrazide chemistry."; RL J. Proteome Res. 8:651-661(2009). RN [15] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [16] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [17] RP X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 25-300. RX PubMed=1525820; DOI=10.1016/0092-8674(92)90252-8; RA Madden D.R., Gorga J.C., Strominger J.L., Wiley D.C.; RT "The three-dimensional structure of HLA-B27 at 2.1-A resolution RT suggests a general mechanism for tight peptide binding to MHC."; RL Cell 70:1035-1048(1992). RN [18] RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 25-300. RX PubMed=1922337; DOI=10.1038/353321a0; RA Madden D.R., Gorga J.C., Strominger J.L., Wiley D.C.; RT "The structure of HLA-B27 reveals nonamer self-peptides bound in an RT extended conformation."; RL Nature 353:321-325(1991). RN [19] RP X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 25-300. RX PubMed=12244049; DOI=10.1074/jbc.M206392200; RA Hulsmeyer M., Hillig R.C., Volz A., Ruhl M., Schroder W., Saenger W., RA Ziegler A., Uchanska-Ziegler B.; RT "HLA-B27 subtypes differentially associated with disease exhibit RT subtle structural alterations."; RL J. Biol. Chem. 277:47844-47853(2002). RN [20] RP 3D-STRUCTURE MODELING OF 115-206. RX PubMed=7846047; DOI=10.1073/pnas.92.3.753; RA Rognan D., Scapozza L., Folkers G., Daser A.; RT "Rational design of nonnatural peptides as high-affinity ligands for RT the HLA-B*2705 human leukocyte antigen."; RL Proc. Natl. Acad. Sci. U.S.A. 92:753-757(1995). RN [21] RP DISEASE, AND POSSIBLE PROTECTIVE ROLE OF ALLELE B*27:07. RX PubMed=15603872; DOI=10.1016/j.humimm.2004.08.177; RA Varnavidou-Nicolaidou A., Karpasitou K., Georgiou D., Stylianou G., RA Kokkofitou A., Michalis C., Constantina C., Gregoriadou C., RA Kyriakides G.; RT "HLA-B27 in the Greek Cypriot population: distribution of subtypes in RT patients with ankylosing spondylitis and other HLA-B27-related RT diseases. The possible protective role of B*2707."; RL Hum. Immunol. 65:1451-1454(2004). RN [22] RP VARIANT [LARGE SCALE ANALYSIS] THR-65, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- INTERACTION: CC P43629:KIR3DL1; NbExp=2; IntAct=EBI-8532782, EBI-3910993; CC Q8N423:LILRB2; NbExp=2; IntAct=EBI-8532782, EBI-2816428; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-27 are known: CC B*27:01=B*27:05, B*27:02 (B27.2; B-27k; B27e), B*27:03 (B27d), CC B*27:04, B*27:06, B*27:07, B*27:08 (B7Qui) and B*27:09 (B27-ci). CC The sequence shown is that of B*27:01. CC -!- DISEASE: Spondyloarthropathy 1 (SPDA1) [MIM:106300]: A chronic CC rheumatic disease with multifactorial inheritance. It includes a CC spectrum of related disorders comprising ankylosing spondylitis, a CC subset of psoriatic arthritis, reactive arthritis (e.g. Reiter CC syndrome), arthritis associated with inflammatory bowel disease CC and undifferentiated spondyloarthropathy. These disorders may CC occur simultaneously or sequentially in the same patient, probably CC representing various phenotypic expressions of the same disease. CC Ankylosing spondylitis is the form of rheumatoid arthritis CC affecting the spine and is considered the prototype of CC seronegative spondyloarthropathies. It produces pain and stiffness CC as a result of inflammation of the sacroiliac, intervertebral, and CC costovertebral joints. Note=Disease susceptibility is associated CC with variations affecting the gene represented in this entry. A CC restricted number of HLA-B27 subtypes can be associated with CC ankylosing spondylitis and other B27-related diseases, and an CC elevated frequency of the B*2702 allele in ankylosing spondylitis CC patients is identified. The allele B*2707 seems to have a CC protective role some populations because it was found only in the CC healthy controls. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X03945; CAA27578.1; ALT_SEQ; Genomic_DNA. DR EMBL; X03664; CAA27301.1; -; Genomic_DNA. DR EMBL; X03667; CAA27301.1; JOINED; Genomic_DNA. DR EMBL; L38504; AAA69724.1; -; mRNA. DR EMBL; M54883; AAA59616.1; -; Genomic_DNA. DR EMBL; X03665; CAA27302.1; -; Genomic_DNA. DR EMBL; X03666; CAA27302.1; JOINED; Genomic_DNA. DR EMBL; M12967; AAA36221.1; -; Genomic_DNA. DR EMBL; U27608; AAC50444.1; -; mRNA. DR EMBL; U35734; AAC50447.1; -; mRNA. DR EMBL; M14013; AAA59643.1; -; Genomic_DNA. DR EMBL; X73578; CAA51980.1; -; mRNA. DR EMBL; M62852; AAA59647.1; -; mRNA. DR EMBL; L19923; AAA59658.1; -; mRNA. DR EMBL; Z33453; CAA83876.1; -; mRNA. DR PIR; I37515; I37515. DR PIR; I56116; I56116. DR PIR; S07441; HLHUB2. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 1HSA; X-ray; 2.10 A; A/D=25-300. DR PDB; 1JGD; X-ray; 1.90 A; A=25-300. DR PDB; 1JGE; X-ray; 2.10 A; A=25-300. DR PDB; 1K5N; X-ray; 1.09 A; A=25-300. DR PDB; 1OF2; X-ray; 2.20 A; A=25-300. DR PDB; 1OGT; X-ray; 1.47 A; A=25-300. DR PDB; 1ROG; Model; -; A=25-206. DR PDB; 1ROH; Model; -; A=25-206. DR PDB; 1ROI; Model; -; A=25-206. DR PDB; 1ROJ; Model; -; A=25-206. DR PDB; 1ROK; Model; -; A=25-206. DR PDB; 1ROL; Model; -; A=25-206. DR PDB; 1UXS; X-ray; 1.55 A; A=25-300. DR PDB; 1UXW; X-ray; 1.71 A; A=25-300. DR PDB; 1W0V; X-ray; 2.27 A; A=25-300. DR PDB; 1W0W; X-ray; 2.10 A; A=25-300. DR PDB; 2A83; X-ray; 1.40 A; A=25-300. DR PDB; 2BSR; X-ray; 2.30 A; A=25-300. DR PDB; 2BSS; X-ray; 2.00 A; A=25-300. DR PDB; 2BST; X-ray; 2.10 A; A=25-300. DR PDB; 3B3I; X-ray; 1.86 A; A=25-300. DR PDB; 3B6S; X-ray; 1.80 A; A=25-300. DR PDB; 3BP4; X-ray; 1.85 A; A=25-300. DR PDB; 3BP7; X-ray; 1.80 A; A=25-300. DR PDB; 3CZF; X-ray; 1.20 A; A=25-300. DR PDB; 3D18; X-ray; 1.74 A; A=25-300. DR PDB; 3DTX; X-ray; 2.10 A; A=25-300. DR PDB; 3HCV; X-ray; 1.95 A; A=25-300. DR PDB; 3LV3; X-ray; 1.94 A; A=25-300. DR PDB; 4G8G; X-ray; 2.40 A; A=25-300. DR PDB; 4G8I; X-ray; 1.60 A; A=25-300. DR PDB; 4G9D; X-ray; 1.60 A; A=25-300. DR PDB; 4G9F; X-ray; 1.90 A; A=25-300. DR PDB; 5DEF; X-ray; 1.60 A; A=25-300. DR PDB; 5DEG; X-ray; 1.83 A; A=25-300. DR PDB; 5IB1; X-ray; 1.91 A; A=25-300. DR PDB; 5IB2; X-ray; 1.44 A; A=25-300. DR PDB; 5IB3; X-ray; 1.91 A; A=25-300. DR PDB; 5IB4; X-ray; 1.95 A; A=25-300. DR PDB; 5IB5; X-ray; 2.49 A; A/D=25-300. DR PDBsum; 1HSA; -. DR PDBsum; 1JGD; -. DR PDBsum; 1JGE; -. DR PDBsum; 1K5N; -. DR PDBsum; 1OF2; -. DR PDBsum; 1OGT; -. DR PDBsum; 1ROG; -. DR PDBsum; 1ROH; -. DR PDBsum; 1ROI; -. DR PDBsum; 1ROJ; -. DR PDBsum; 1ROK; -. DR PDBsum; 1ROL; -. DR PDBsum; 1UXS; -. DR PDBsum; 1UXW; -. DR PDBsum; 1W0V; -. DR PDBsum; 1W0W; -. DR PDBsum; 2A83; -. DR PDBsum; 2BSR; -. DR PDBsum; 2BSS; -. DR PDBsum; 2BST; -. DR PDBsum; 3B3I; -. DR PDBsum; 3B6S; -. DR PDBsum; 3BP4; -. DR PDBsum; 3BP7; -. DR PDBsum; 3CZF; -. DR PDBsum; 3D18; -. DR PDBsum; 3DTX; -. DR PDBsum; 3HCV; -. DR PDBsum; 3LV3; -. DR PDBsum; 4G8G; -. DR PDBsum; 4G8I; -. DR PDBsum; 4G9D; -. DR PDBsum; 4G9F; -. DR PDBsum; 5DEF; -. DR PDBsum; 5DEG; -. DR PDBsum; 5IB1; -. DR PDBsum; 5IB2; -. DR PDBsum; 5IB3; -. DR PDBsum; 5IB4; -. DR PDBsum; 5IB5; -. DR ProteinModelPortal; P03989; -. DR SMR; P03989; -. DR DIP; DIP-6188N; -. DR IntAct; P03989; 6. DR MINT; P03989; -. DR DrugBank; DB04464; N-Formylmethionine. DR iPTMnet; P03989; -. DR SwissPalm; P03989; -. DR DMDM; 34305677; -. DR PeptideAtlas; P03989; -. DR PRIDE; P03989; -. DR Ensembl; ENST00000435618; ENSP00000405178; ENSG00000224608. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 106300; phenotype. DR MIM; 142830; gene. DR neXtProt; NX_P03989; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR PhylomeDB; P03989; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR EvolutionaryTrace; P03989; -. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; IDA:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0016020; C:membrane; TAS:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; IDA:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; IDA:UniProtKB. DR GO; GO:0002486; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0006952; P:defense response; TAS:UniProtKB. DR GO; GO:0016045; P:detection of bacterium; IMP:UniProtKB. DR GO; GO:0006955; P:immune response; IMP:UniProtKB. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Direct protein sequencing; KW Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I; Polymorphism; KW Reference proteome; Signal; Transmembrane; Transmembrane helix; KW Ubl conjugation. FT SIGNAL 1 24 {ECO:0000269|PubMed:2408663}. FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-27 alpha chain. FT /FTId=PRO_0000018839. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:19159218}. FT DISULFID 125 188 FT DISULFID 227 283 FT VARIANT 65 65 A -> T (in dbSNP:rs1050529). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056341. FT VARIANT 83 83 Y -> H (in allele B*27:03). FT /FTId=VAR_016379. FT VARIANT 101 101 D -> N (in allele B*27:02). FT /FTId=VAR_016380. FT VARIANT 101 101 D -> S (in allele B*27:04, allele B*27:06 FT and allele B*27:08; requires 2 nucleotide FT substitutions). FT /FTId=VAR_016381. FT VARIANT 104 105 TL -> IA (in allele B*27:02). FT /FTId=VAR_016382. FT VARIANT 104 104 T -> N (in allele B*27:08). FT /FTId=VAR_016383. FT VARIANT 106 107 LR -> RG (in allele B*27:08). FT /FTId=VAR_016384. FT VARIANT 121 121 N -> S (in allele B*27:07). FT /FTId=VAR_016385. FT VARIANT 137 138 YH -> HN (in allele B*27:07). FT /FTId=VAR_016386. FT VARIANT 138 138 H -> D (in allele B*27:06). FT /FTId=VAR_016387. FT VARIANT 140 140 D -> H (in allele B*27:09). FT /FTId=VAR_016388. FT VARIANT 140 140 D -> Y (in allele B*27:06 and allele FT B*27:07). FT /FTId=VAR_016389. FT VARIANT 155 155 S -> R (in allele B*27:07). FT /FTId=VAR_016390. FT VARIANT 176 176 V -> E (in allele B*27:04 and allele FT B*27:06). FT /FTId=VAR_016391. FT VARIANT 235 235 A -> G (in allele B*27:04 and allele FT B*27:06). FT /FTId=VAR_016392. FT VARIANT 306 306 V -> I (in dbSNP:rs1131500). FT /FTId=VAR_056342. FT VARIANT 329 329 A -> T (in dbSNP:rs1051488). FT /FTId=VAR_056343. FT VARIANT 349 349 C -> S (in dbSNP:rs2308655). FT /FTId=VAR_061402. FT VARIANT 349 349 C -> Y (in dbSNP:rs2308655). FT /FTId=VAR_061403. FT CONFLICT 206 206 A -> V (in Ref. 2). {ECO:0000305}. FT CONFLICT 266 266 Q -> E (in Ref. 3; AA sequence). FT {ECO:0000305}. FT STRAND 27 36 {ECO:0000244|PDB:1K5N}. FT STRAND 41 43 {ECO:0000244|PDB:1K5N}. FT STRAND 45 52 {ECO:0000244|PDB:1K5N}. FT STRAND 55 61 {ECO:0000244|PDB:1K5N}. FT STRAND 64 66 {ECO:0000244|PDB:1K5N}. FT HELIX 74 76 {ECO:0000244|PDB:1K5N}. FT HELIX 81 108 {ECO:0000244|PDB:1K5N}. FT STRAND 113 115 {ECO:0000244|PDB:1K5N}. FT STRAND 118 127 {ECO:0000244|PDB:1K5N}. FT STRAND 133 142 {ECO:0000244|PDB:1K5N}. FT STRAND 145 150 {ECO:0000244|PDB:1K5N}. FT STRAND 157 161 {ECO:0000244|PDB:1K5N}. FT HELIX 162 173 {ECO:0000244|PDB:1K5N}. FT HELIX 176 185 {ECO:0000244|PDB:1K5N}. FT HELIX 187 198 {ECO:0000244|PDB:1K5N}. FT TURN 199 204 {ECO:0000244|PDB:1K5N}. FT STRAND 210 219 {ECO:0000244|PDB:1K5N}. FT STRAND 222 235 {ECO:0000244|PDB:1K5N}. FT STRAND 238 243 {ECO:0000244|PDB:1K5N}. FT HELIX 249 251 {ECO:0000244|PDB:1K5N}. FT STRAND 252 254 {ECO:0000244|PDB:5DEF}. FT STRAND 261 263 {ECO:0000244|PDB:1K5N}. FT STRAND 265 274 {ECO:0000244|PDB:1K5N}. FT HELIX 278 280 {ECO:0000244|PDB:1K5N}. FT STRAND 281 286 {ECO:0000244|PDB:1K5N}. FT STRAND 290 292 {ECO:0000244|PDB:3CZF}. FT STRAND 294 296 {ECO:0000244|PDB:1K5N}. SQ SEQUENCE 362 AA; 40428 MW; C8D2F154E3292031 CRC64; MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFHTSVSRPG RGEPRFITVG YVDDTLFVRF DSDAASPREE PRAPWIEQEG PEYWDRETQI CKAKAQTDRE DLRTLLRYYN QSEAGSHTLQ NMYGCDVGPD GRLLRGYHQD AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGECVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA // ID 1B35_HUMAN Reviewed; 362 AA. AC P30685; O62919; P30468; P30469; P30470; P30471; P30472; P30473; AC P30474; Q9GJM7; Q9TPV2; Q9TQH3; Q9TQH9; Q9TQN4; Q9TQN6; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 167. DE RecName: Full=HLA class I histocompatibility antigen, B-35 alpha chain; DE AltName: Full=MHC class I antigen B*35; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*35:01). RX PubMed=2788131; DOI=10.1007/BF02421534; RA Ooba T., Hayashi H., Karaki S., Tanabe M., Kano K., Takiguchi M.; RT "The structure of HLA-B35 suggests that it is derived from HLA-Bw58 by RT two genetic mechanisms."; RL Immunogenetics 30:76-80(1989). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*35:02). RX PubMed=1890016; DOI=10.1016/0198-8859(91)90020-A; RA Chertkoff L.P., Herrera M., Fainboim L., Satz M.L.; RT "Complete nucleotide sequence of a genomic clone encoding HLA-B35 RT isolated from a Caucasian individual of Hispanic origin. RT Identification of a new variant of HLA-B35."; RL Hum. Immunol. 31:153-158(1991). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*35:03). RX PubMed=1541831; RA Zemmour J., Little A.-M., Schendel D.J., Parham P.; RT "The HLA-A,B 'negative' mutant cell line C1R expresses a novel HLA-B35 RT allele, which also has a point mutation in the translation initiation RT codon."; RL J. Immunol. 148:1941-1948(1992). RN [4] RP NUCLEOTIDE SEQUENCE (ALLELE B*35:03). RC TISSUE=Blood; RX PubMed=7759996; DOI=10.1084/jem.181.6.2037; RA Beck Y., Satz L., Takamiya Y., Nakayama S., Ling L., Ishikawa Y., RA Nagao T., Uchida H., Tokunaga K., Mueller C., Juji T., Takiguchi M.; RT "Polymorphism of human minor histocompatibility antigens: T cell RT recognition of human minor histocompatibility peptides presented by RT HLA-B35 subtype molecules."; RL J. Exp. Med. 181:2037-2048(1995). RN [5] RP NUCLEOTIDE SEQUENCE (ALLELES B*35:05 AND B*35:06). RX PubMed=1317015; DOI=10.1038/357326a0; RA Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J., RA Williams R.C., Luz R., Petzl-Erler M.L., Parham P.; RT "Unusual HLA-B alleles in two tribes of Brazilian Indians."; RL Nature 357:326-329(1992). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*35:07 AND B*35:08). RX PubMed=8316945; DOI=10.1111/j.1399-0039.1993.tb01993.x; RA Theiler G., Pando M., Delfino J.M., Takiguchi M., Satz M.L.; RT "Isolation and characterization of two new functional subtypes of HLA- RT B35."; RL Tissue Antigens 41:143-147(1993). RN [7] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*35:08). RX PubMed=8138421; DOI=10.1016/0198-8859(93)90553-D; RA Steinle A., Reinhardt C., Noessner E., Uchanska-Ziegler B., RA Ziegler A., Schendel D.J.; RT "Microheterogeneity in HLA-B35 alleles influences peptide-dependent RT allorecognition by cytotoxic T cells but not binding of a peptide- RT restricted monoclonal antibody."; RL Hum. Immunol. 38:261-269(1993). RN [8] RP NUCLEOTIDE SEQUENCE OF 9-362 (ALLELE B*35:04). RX PubMed=1589035; DOI=10.1038/357329a0; RA Watkins D.I., McAdam S.N., Liu X., Stang C.R., Milford E.L., RA Levine C.G., Garber T.L., Dogon A.L., Lord C.I., Ghim S.H., RA Troup G.M., Hughes A.L., Letvin N.L.; RT "New recombinant HLA-B alleles in a tribe of South American RT Amerindians indicate rapid evolution of MHC class I loci."; RL Nature 357:329-333(1992). RN [9] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES B*35:29 AND RP B*35:32). RX PubMed=10777103; DOI=10.1034/j.1399-0039.2000.550311.x; RA Kennedy C.T., Dodd R., Le T., Wallace R., Ng G., Greville W.D., RA Kennedy A., Taverniti A., Moses J.H., Clow N., Watson N., Dunckley H.; RT "Routine HLA-B genotyping with PCR-sequence-specific oligonucleotides RT (PCR-SSO) detects eight new alleles: B*0807, B*0809, B*1551, B*3529, RT B*3532, B*4025, B*5304 and B*5508."; RL Tissue Antigens 55:266-270(2000). RN [10] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES B*35:25; B*35:28; B*35:29; RP B*35:30 AND B*35:36). RX PubMed=11556976; DOI=10.1034/j.1399-0039.2001.057005481.x; RA Steiner N.K., Kosman C., Jones P.F., Gans C.P., Rodriguez-Marino S.G., RA Rizzuto G., Baldassarre L.A., Edson S., Koester R., Sese D., RA Mitton W., Ng J., Hartzman R.J., Hurley C.K.; RT "Twenty-nine new HLA-B alleles associated with antigens in the 5C RT CREG."; RL Tissue Antigens 57:481-485(2001). RN [11] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [12] RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 25-300. RX PubMed=8624811; DOI=10.1016/S1074-7613(00)80429-X; RA Smith K.J., Reid S.W., Stuart D.I., McMichael A.J., Jones E.Y., RA Bell J.I.; RT "An altered position of the alpha 2 helix of MHC class I is revealed RT by the crystal structure of HLA-B*3501."; RL Immunity 4:203-214(1996). RN [13] RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS). RX PubMed=9878435; DOI=10.1006/jmbi.1998.2363; RA Menssen R., Orth P., Ziegler A., Saenger W.; RT "Decamer-like conformation of a nona-peptide bound to HLA-B*3501 due RT to non-standard positioning of the C-terminus."; RL J. Mol. Biol. 285:645-653(1999). RN [14] RP VARIANT [LARGE SCALE ANALYSIS] TYR-140, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [15] RP VARIANT [LARGE SCALE ANALYSIS] GLU-87, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-35 are known: B*35:01, CC B*35:02, B*35:03, B*35:04, B*35:05 (B35-G), B*35:06 (B35-K), CC B*35:07, B*35:08, B*35:25, B*35:28, B*35:29 (B*KG), B*35:30, CC B*35:32 (B*TMUL) and B*35:36. The sequence shown is that of CC B*35:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M28115; AAA59617.1; -; Genomic_DNA. DR EMBL; M28109; AAA59617.1; JOINED; Genomic_DNA. DR EMBL; M28110; AAA59617.1; JOINED; Genomic_DNA. DR EMBL; M28111; AAA59617.1; JOINED; Genomic_DNA. DR EMBL; M28112; AAA59617.1; JOINED; Genomic_DNA. DR EMBL; M28113; AAA59617.1; JOINED; Genomic_DNA. DR EMBL; M28114; AAA59617.1; JOINED; Genomic_DNA. DR EMBL; M63454; AAA59682.1; -; Genomic_DNA. DR EMBL; M81798; AAA59684.1; -; mRNA. DR EMBL; D50299; BAA08828.1; -; mRNA. DR EMBL; M84385; AAA59635.1; -; mRNA. DR EMBL; M84381; AAA59631.1; -; mRNA. DR EMBL; L04695; AAA59694.1; -; mRNA. DR EMBL; L04696; AAA52674.1; -; mRNA. DR EMBL; Z22651; CAA80366.1; -; mRNA. DR EMBL; M86403; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AH007565; AAD23460.1; -; Genomic_DNA. DR EMBL; AH007706; AAD30277.1; -; Genomic_DNA. DR EMBL; AH006372; AAC32570.1; -; Genomic_DNA. DR EMBL; AH007604; AAD27538.1; -; Genomic_DNA. DR EMBL; AH008126; AAD51745.1; -; Genomic_DNA. DR EMBL; AH007584; AAD26151.1; -; Genomic_DNA. DR EMBL; AH009759; AAG01819.1; -; Genomic_DNA. DR PIR; A45880; A45880. DR PIR; I54298; I54298. DR PIR; I56133; I56133. DR PIR; I61904; I61904. DR PIR; I61907; I61907. DR PIR; I81233; I81233. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 1A1N; X-ray; 2.00 A; A=25-300. DR PDB; 1A9B; X-ray; 3.20 A; A/D=25-301. DR PDB; 1A9E; X-ray; 2.50 A; A=25-301. DR PDB; 1CG9; X-ray; 2.70 A; A=25-301. DR PDB; 1XH3; X-ray; 1.48 A; A=25-300. DR PDB; 1ZHK; X-ray; 1.60 A; A=25-300. DR PDB; 1ZHL; X-ray; 1.50 A; A=25-300. DR PDB; 1ZSD; X-ray; 1.70 A; A=25-300. DR PDB; 2AK4; X-ray; 2.50 A; A/F/K/Q=25-300. DR PDB; 2AXF; X-ray; 1.80 A; A=25-300. DR PDB; 2AXG; X-ray; 2.00 A; A=25-300. DR PDB; 2CIK; X-ray; 1.75 A; A=25-300. DR PDB; 2FYY; X-ray; 1.50 A; A=25-300. DR PDB; 2FZ3; X-ray; 1.90 A; A=25-300. DR PDB; 2H6P; X-ray; 1.90 A; A=25-300. DR PDB; 2NW3; X-ray; 1.70 A; A=25-300. DR PDB; 2NX5; X-ray; 2.70 A; A/F/K/Q=25-300. DR PDB; 3BW9; X-ray; 1.75 A; A=25-300. DR PDB; 3BWA; X-ray; 1.30 A; A=25-300. DR PDB; 3KWW; X-ray; 2.18 A; A=25-300. DR PDB; 3KXF; X-ray; 3.10 A; A/C/I/K=25-300. DR PDB; 3LKN; X-ray; 2.00 A; A=25-300. DR PDB; 3LKO; X-ray; 1.80 A; A=25-300. DR PDB; 3LKP; X-ray; 1.80 A; A=25-300. DR PDB; 3LKQ; X-ray; 1.80 A; A=25-300. DR PDB; 3LKR; X-ray; 2.00 A; A=25-300. DR PDB; 3LKS; X-ray; 1.90 A; A=25-300. DR PDB; 3MV7; X-ray; 2.00 A; A=25-300. DR PDB; 3MV8; X-ray; 2.10 A; A=25-300. DR PDB; 3MV9; X-ray; 2.70 A; A=25-300. DR PDB; 3VFS; X-ray; 1.85 A; A=25-300. DR PDB; 3VFT; X-ray; 1.95 A; A=25-300. DR PDB; 3VFU; X-ray; 1.65 A; A=25-300. DR PDB; 3VFV; X-ray; 1.55 A; A=25-300. DR PDB; 3VFW; X-ray; 2.30 A; A=25-300. DR PDB; 4LNR; X-ray; 2.00 A; A=25-300. DR PDB; 4PR5; X-ray; 1.80 A; A=25-300. DR PDB; 4PRN; X-ray; 1.65 A; A=25-300. DR PDB; 4QRR; X-ray; 3.00 A; A=25-300. DR PDB; 5XOS; X-ray; 1.70 A; A=25-300. DR PDB; 5XOT; X-ray; 2.79 A; A=25-300. DR PDBsum; 1A1N; -. DR PDBsum; 1A9B; -. DR PDBsum; 1A9E; -. DR PDBsum; 1CG9; -. DR PDBsum; 1XH3; -. DR PDBsum; 1ZHK; -. DR PDBsum; 1ZHL; -. DR PDBsum; 1ZSD; -. DR PDBsum; 2AK4; -. DR PDBsum; 2AXF; -. DR PDBsum; 2AXG; -. DR PDBsum; 2CIK; -. DR PDBsum; 2FYY; -. DR PDBsum; 2FZ3; -. DR PDBsum; 2H6P; -. DR PDBsum; 2NW3; -. DR PDBsum; 2NX5; -. DR PDBsum; 3BW9; -. DR PDBsum; 3BWA; -. DR PDBsum; 3KWW; -. DR PDBsum; 3KXF; -. DR PDBsum; 3LKN; -. DR PDBsum; 3LKO; -. DR PDBsum; 3LKP; -. DR PDBsum; 3LKQ; -. DR PDBsum; 3LKR; -. DR PDBsum; 3LKS; -. DR PDBsum; 3MV7; -. DR PDBsum; 3MV8; -. DR PDBsum; 3MV9; -. DR PDBsum; 3VFS; -. DR PDBsum; 3VFT; -. DR PDBsum; 3VFU; -. DR PDBsum; 3VFV; -. DR PDBsum; 3VFW; -. DR PDBsum; 4LNR; -. DR PDBsum; 4PR5; -. DR PDBsum; 4PRN; -. DR PDBsum; 4QRR; -. DR PDBsum; 5XOS; -. DR PDBsum; 5XOT; -. DR ProteinModelPortal; P30685; -. DR SMR; P30685; -. DR IntAct; P30685; 6. DR MINT; P30685; -. DR SwissPalm; P30685; -. DR DMDM; 231390; -. DR EPD; P30685; -. DR PeptideAtlas; P30685; -. DR PRIDE; P30685; -. DR Ensembl; ENST00000359635; ENSP00000352656; ENSG00000206450. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR H-InvDB; HIX0167180; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30685; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR EvolutionaryTrace; P30685; -. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-35 alpha chain. FT /FTId=PRO_0000018840. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 FT DISULFID 227 283 FT VARIANT 40 40 G -> V (in allele B*35:07). FT /FTId=VAR_016393. FT VARIANT 48 48 A -> S (in allele B*35:25). FT /FTId=VAR_016394. FT VARIANT 69 69 T -> E (in allele B*35:25; requires 2 FT nucleotide substitutions). FT /FTId=VAR_016395. FT VARIANT 87 87 N -> E (in allele B*35:28; requires 2 FT nucleotide substitutions). FT {ECO:0000244|PubMed:24275569}. FT /FTId=VAR_016396. FT VARIANT 91 91 F -> S (in allele B*35:28). FT /FTId=VAR_016397. FT VARIANT 98 98 Y -> D (in allele B*35:29). FT /FTId=VAR_016398. FT VARIANT 107 107 G -> D (in allele B*35:36). FT /FTId=VAR_016399. FT VARIANT 118 119 II -> TL (in allele B*35:05 and allele FT B*35:32). FT /FTId=VAR_016400. FT VARIANT 121 121 R -> S (in allele B*35:05 and allele FT B*35:30). FT /FTId=VAR_016401. FT VARIANT 127 127 L -> V (in allele B*35:32). FT /FTId=VAR_016402. FT VARIANT 133 133 L -> F (in allele B*35:02). FT /FTId=VAR_016403. FT VARIANT 138 138 D -> N (in allele B*35:02, allele B*35:04 FT and allele B*35:06). FT /FTId=VAR_016404. FT VARIANT 140 140 S -> F (in allele B*35:06 and allele FT B*35:36). FT /FTId=VAR_016405. FT VARIANT 140 140 S -> Y (in allele B*35:02, allele B*35:03 FT and allele B*35:04). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_016406. FT VARIANT 180 180 L -> R (in allele B*35:08). FT /FTId=VAR_016407. FT STRAND 27 36 {ECO:0000244|PDB:3BWA}. FT STRAND 41 43 {ECO:0000244|PDB:3BWA}. FT STRAND 45 52 {ECO:0000244|PDB:3BWA}. FT STRAND 55 61 {ECO:0000244|PDB:3BWA}. FT STRAND 64 66 {ECO:0000244|PDB:3BWA}. FT STRAND 70 73 {ECO:0000244|PDB:5XOT}. FT HELIX 74 76 {ECO:0000244|PDB:3BWA}. FT HELIX 81 108 {ECO:0000244|PDB:3BWA}. FT STRAND 113 115 {ECO:0000244|PDB:3BW9}. FT STRAND 118 127 {ECO:0000244|PDB:3BWA}. FT STRAND 133 142 {ECO:0000244|PDB:3BWA}. FT STRAND 145 150 {ECO:0000244|PDB:3BWA}. FT STRAND 157 161 {ECO:0000244|PDB:3BWA}. FT HELIX 162 173 {ECO:0000244|PDB:3BWA}. FT HELIX 176 185 {ECO:0000244|PDB:3BWA}. FT HELIX 187 198 {ECO:0000244|PDB:3BWA}. FT HELIX 200 203 {ECO:0000244|PDB:3BWA}. FT STRAND 210 217 {ECO:0000244|PDB:3BWA}. FT STRAND 219 235 {ECO:0000244|PDB:3BWA}. FT STRAND 238 243 {ECO:0000244|PDB:3BWA}. FT HELIX 249 251 {ECO:0000244|PDB:3BWA}. FT STRAND 252 254 {ECO:0000244|PDB:1ZHL}. FT STRAND 261 263 {ECO:0000244|PDB:3BWA}. FT STRAND 265 274 {ECO:0000244|PDB:3BWA}. FT HELIX 278 280 {ECO:0000244|PDB:3BWA}. FT STRAND 281 286 {ECO:0000244|PDB:3BWA}. FT STRAND 290 292 {ECO:0000244|PDB:1ZHK}. FT STRAND 294 296 {ECO:0000244|PDB:3BWA}. SQ SEQUENCE 362 AA; 40455 MW; 52906854FC43E7A6 CRC64; MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRTE PRAPWIEQEG PEYWDRNTQI FKTNTQTYRE SLRNLRGYYN QSEAGSHIIQ RMYGCDLGPD GRLLRGHDQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B37_HUMAN Reviewed; 362 AA. AC P18463; O19627; Q546L8; Q95HA3; Q95HA8; Q95HM9; Q9GJ31; DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1990, sequence version 1. DT 12-SEP-2018, entry version 148. DE RecName: Full=HLA class I histocompatibility antigen, B-37 alpha chain; DE AltName: Full=MHC class I antigen B*37; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*37:01). RX PubMed=2320591; DOI=10.1073/pnas.87.7.2833; RA Ennis P.D., Zemmour J., Salter R.D., Parham P.; RT "Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: RT frequency and nature of errors produced in amplification."; RL Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*37:01). RC TISSUE=Blood; RA Cox S.T.; RT "Confirmation of B*3701."; RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE B*37:04). RC TISSUE=Peripheral blood; RX PubMed=12028544; DOI=10.1034/j.1399-0039.2002.590213.x; RA Estefania E., Gomez-Lozano N., de Pablo R., Moreno M.E., Vilches C.; RT "Complementary DNA sequence of the novel HLA-B*3704 allele."; RL Tissue Antigens 59:142-144(2002). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*37:05). RX PubMed=12135437; DOI=10.1034/j.1399-0039.2002.590416.x; RA Pyo C.-W., Han H., Kim T.G.; RT "Identification of a new HLA-B allele, B*3705 containing a Bw6 RT sequence motif."; RL Tissue Antigens 59:335-337(2002). RN [5] RP NUCLEOTIDE SEQUENCE OF 1-322 (ALLELE B*37:01). RA Hurley C.K., Bei M., Rodriguez S., Johnson A.; RL Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*37:04). RA Gans C.P., Hurley C.K.; RT "Novel HLA-B allele."; RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [9] RP VARIANT [LARGE SCALE ANALYSIS] THR-65, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-37 are known: B*37:01, CC B*37:04 and B*37:05. The sequence shown is that of B*37:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M32320; AAA36233.1; -; mRNA. DR EMBL; AJ310358; CAC38763.1; -; Genomic_DNA. DR EMBL; AF389378; AAL26324.1; -; mRNA. DR EMBL; AF418978; AAL07502.1; -; mRNA. DR EMBL; AH010966; AAK82990.1; -; Genomic_DNA. DR EMBL; U11267; AAA19927.1; -; mRNA. DR EMBL; AH009869; AAG21400.1; -; Genomic_DNA. DR PIR; C35997; C35997. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; P18463; -. DR SMR; P18463; -. DR SwissPalm; P18463; -. DR DMDM; 122160; -. DR EPD; P18463; -. DR MaxQB; P18463; -. DR PeptideAtlas; P18463; -. DR PRIDE; P18463; -. DR Ensembl; ENST00000359635; ENSP00000352656; ENSG00000206450. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P18463; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR PhylomeDB; P18463; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-37 alpha chain. FT /FTId=PRO_0000018841. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 35 35 S -> A (in dbSNP:rs1131170). FT /FTId=VAR_056344. FT VARIANT 36 36 V -> M (in dbSNP:rs1050486). FT /FTId=VAR_056345. FT VARIANT 48 48 S -> A (in dbSNP:rs713031). FT /FTId=VAR_061404. FT VARIANT 48 48 S -> P (in dbSNP:rs713031). FT /FTId=VAR_061405. FT VARIANT 48 48 S -> T (in dbSNP:rs713031). FT /FTId=VAR_061406. FT VARIANT 65 65 A -> T (in dbSNP:rs1050529). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056346. FT VARIANT 104 104 T -> N (in allele B*37:05). FT /FTId=VAR_016408. FT VARIANT 106 107 LR -> RG (in allele B*37:05). FT /FTId=VAR_016409. FT VARIANT 195 195 Y -> H (in allele B*37:04). FT /FTId=VAR_016410. SQ SEQUENCE 362 AA; 40456 MW; FAB4375F05474725 CRC64; MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFHTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRTE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE DLRTLLRYYN QSEAGSHTIQ RMSGCDVGPD GRLLRGYNQF AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQD RAYLEGTCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B38_HUMAN Reviewed; 362 AA. AC Q95365; O19779; O77959; O78160; Q29935; Q29936; Q95IB8; Q95IH5; AC Q9BCM8; Q9MY92; Q9MYG1; Q9TPT2; DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 12-SEP-2018, entry version 139. DE RecName: Full=HLA class I histocompatibility antigen, B-38 alpha chain; DE AltName: Full=Bw-4; DE AltName: Full=MHC class I antigen B*38; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*38:01). RX PubMed=7725307; DOI=10.1111/j.1399-0039.1995.tb02410.x; RA Adams E.J., Martinez-Naves E., Arnett K.L., Little A.-M., Tyan D.B., RA Parham P.; RT "HLA-B16 antigens: sequence of the ST-16 antigen, further definition RT of two B38 subtypes and evidence for convergent evolution of B*3902."; RL Tissue Antigens 45:18-26(1995). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE B*38:01). RA Morlighem G.; RL Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE B*38:02). RA Little A.-M., Domena J.D., Hildebrand W.H., Parham P.; RL Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE (ALLELE B*38:02). RC TISSUE=Blood; RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [5] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:02). RX PubMed=9455497; DOI=10.1016/S0198-8859(97)00112-2; RA Steiner N.K., Ng J., Bush J., Hartzman R.J., Johnston-Dow L., RA Hurley C.K.; RT "HLA-B alleles associated with the B15 serologically defined RT antigens."; RL Hum. Immunol. 56:84-93(1997). RN [6] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:02). RA Guttridge M.G., Hammond L., Darke C.; RT "Confirmatory sequence and serology of HLA-B*38021."; RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 26-206 (ALLELE B*38:03). RX PubMed=10323342; DOI=10.1034/j.1399-0039.1999.530408.x; RA Balas A., Santos S., Garcia-Sanchez F., Lillo R., Merino J.L., RA Vicario J.L.; RT "Characterization of a new HLA-B*38 allele (B*3803) in a Spanish RT Caucasian individual which is closely related to the Oriental B*38021 RT and B*39021 alleles."; RL Tissue Antigens 53:374-377(1999). RN [8] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES B*38:04 AND B*38:06). RX PubMed=11380951; DOI=10.1034/j.1399-0039.2001.057004373.x; RA Steiner N.K., Gans C.P., Kosman C., Baldassarre L.A., Edson S., RA Jones P.F., Rizzuto G., Pimtanothai N., Koester R., Mitton W., Ng J., RA Hartzman R.J., Hurley C.K.; RT "Novel HLA-B alleles associated with antigens in the 8C CREG."; RL Tissue Antigens 57:373-375(2001). RN [9] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-298 (ALLELE B*38:05). RX PubMed=11972879; DOI=10.1034/j.1399-0039.2002.590109.x; RA Garcia-Sanchez F., Fernandez-De-Velasco J., Lillo R., RA Alvarez-Doval A., Rodriguez M.A., Aviles M.J., Balas A., Vicario J.L.; RT "Two new HLA class I alleles recognised by PCR sequence-specific RT primer and sequencing based typing: B*3805 and Cw*0408."; RL Tissue Antigens 59:47-48(2002). RN [10] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:07). RA Cavett J.W., Hildebrand W.H., Bennett T.T., Sparkman J.N.; RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases. RN [11] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:08). RA Chapman G., Dodd R., Greville W.D., Dunckley H.; RT "Novel HLA-B allele Identified by PCR SSO."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [12] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-298 (ALLELE B*38:01). RX PubMed=2777338; DOI=10.1007/BF02421207; RA Mueller C.A., Engler-Blum G., Gekeler V., Steiert I., Weiss E., RA Schmidt H.; RT "Genetic and serological heterogeneity of the supertypic HLA-B locus RT specificities Bw4 and Bw6."; RL Immunogenetics 30:200-207(1989). RN [13] RP VARIANT [LARGE SCALE ANALYSIS] THR-65, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [14] RP VARIANT [LARGE SCALE ANALYSIS] GLU-87, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [15] RP VARIANT [LARGE SCALE ANALYSIS] THR-69, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-38 are known: B*38:01, CC B*38:02, B*38:03, B*38:04, B*38:05, B*38:06, B*38:07 and B*38:08. CC The sequence shown is that of B*38:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; L36591; AAA73509.1; -; mRNA. DR EMBL; U40498; AAD00010.1; -; mRNA. DR EMBL; L22028; AAA59618.1; -; mRNA. DR EMBL; AJ297317; CAC29063.1; -; Genomic_DNA. DR EMBL; AH005604; AAB82305.1; -; Genomic_DNA. DR EMBL; AJ308991; CAC34965.1; -; Genomic_DNA. DR EMBL; AJ308992; CAC34965.1; JOINED; Genomic_DNA. DR EMBL; AF081275; AAC32198.1; -; mRNA. DR EMBL; AF081276; AAC32199.1; -; Genomic_DNA. DR EMBL; AH008211; AAD56222.1; -; Genomic_DNA. DR EMBL; AH009484; AAF78055.1; -; Genomic_DNA. DR EMBL; AH009277; AAF67340.1; -; Genomic_DNA. DR EMBL; AH010893; AAK69506.1; -; Genomic_DNA. DR EMBL; AH011066; AAL04500.1; -; Genomic_DNA. DR EMBL; M29864; AAA36222.1; -; Genomic_DNA. DR PIR; A59028; A59028. DR PIR; I54463; I54463. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; Q95365; -. DR SMR; Q95365; -. DR SwissPalm; Q95365; -. DR DMDM; 34305608; -. DR MaxQB; Q95365; -. DR PeptideAtlas; Q95365; -. DR PRIDE; Q95365; -. DR Ensembl; ENST00000425848; ENSP00000400842; ENSG00000223532. DR UCSC; uc011fcq.2; human. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_Q95365; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-2172127; DAP12 interactions. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0045087; P:innate immune response; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-38 alpha chain. FT /FTId=PRO_0000018842. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 4 4 M -> T (in dbSNP:rs1050458). FT /FTId=VAR_056347. FT VARIANT 9 9 V -> L (in dbSNP:rs1050462). FT /FTId=VAR_056348. FT VARIANT 17 17 L -> V (in dbSNP:rs1131165). FT /FTId=VAR_056349. FT VARIANT 35 35 S -> A (in allele B*38:05; FT dbSNP:rs1131170). FT /FTId=VAR_016411. FT VARIANT 36 36 V -> M (in dbSNP:rs1050486). FT /FTId=VAR_056350. FT VARIANT 48 48 S -> A (in dbSNP:rs713031). FT /FTId=VAR_061407. FT VARIANT 48 48 S -> P (in dbSNP:rs713031). FT /FTId=VAR_061408. FT VARIANT 48 48 S -> T (in dbSNP:rs713031). FT /FTId=VAR_061409. FT VARIANT 65 65 A -> T (in dbSNP:rs1050529). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056351. FT VARIANT 69 69 E -> T (in allele B*38:06 and allele FT B*38:07; requires 2 nucleotide FT substitutions). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_016412. FT VARIANT 82 82 E -> G (in allele B*38:07). FT /FTId=VAR_016413. FT VARIANT 87 87 N -> D (in dbSNP:rs1050570). FT /FTId=VAR_056352. FT VARIANT 87 87 N -> E (in allele B*38:03 and allele FT B*38:04; requires 2 nucleotide FT substitutions). FT {ECO:0000244|PubMed:24275569}. FT /FTId=VAR_016414. FT VARIANT 87 87 N -> K (in dbSNP:rs1065386). FT /FTId=VAR_059478. FT VARIANT 91 91 C -> F (in allele B*38:06 and allele FT B*38:07). FT /FTId=VAR_016415. FT VARIANT 91 91 C -> S (in allele B*38:03). FT /FTId=VAR_016416. FT VARIANT 98 98 Y -> D (in allele B*38:03). FT /FTId=VAR_016417. FT VARIANT 101 101 N -> S (in allele B*38:03). FT /FTId=VAR_016418. FT VARIANT 104 104 I -> T (in allele B*38:02, allele FT B*38:03, allele B*38:04 and allele FT B*38:08). FT /FTId=VAR_016419. FT VARIANT 187 187 T -> M (in allele B*38:08). FT /FTId=VAR_016420. FT VARIANT 306 306 V -> I (in dbSNP:rs1131500). FT /FTId=VAR_056353. FT VARIANT 329 329 A -> T (in dbSNP:rs1051488). FT /FTId=VAR_056354. FT CONFLICT 130 131 DG -> ER (in Ref. 12; AAA36222). FT {ECO:0000305}. FT CONFLICT 191 192 WL -> CV (in Ref. 12; AAA36222). FT {ECO:0000305}. SQ SEQUENCE 362 AA; 40416 MW; 41F49A1A19DF21C7 CRC64; MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI CKTNTQTYRE NLRIALRYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHNQF AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RTYLEGTCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B39_HUMAN Reviewed; 362 AA. AC P30475; O02960; O78217; P30476; P79504; Q29665; Q29697; Q29749; AC Q29847; Q29852; Q29858; Q8HWF0; Q9TPQ7; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 151. DE RecName: Full=HLA class I histocompatibility antigen, B-39 alpha chain; DE AltName: Full=MHC class I antigen B*39; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES B*39:01 AND B*39:02). RX PubMed=8420828; DOI=10.1007/BF00191887; RA Kato N., Karaki S., Kashiwase K., Mueller C., Akaza T., Juji T., RA Kano K., Takiguchi M.; RT "Molecular analysis of HLA-B39 subtypes."; RL Immunogenetics 37:212-216(1993). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*39:02 AND B*39:05). RX PubMed=7725307; DOI=10.1111/j.1399-0039.1995.tb02410.x; RA Adams E.J., Martinez-Naves E., Arnett K.L., Little A.-M., Tyan D.B., RA Parham P.; RT "HLA-B16 antigens: sequence of the ST-16 antigen, further definition RT of two B38 subtypes and evidence for convergent evolution of B*3902."; RL Tissue Antigens 45:18-26(1995). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*39:04). RC TISSUE=Peripheral blood; RX PubMed=7533753; DOI=10.1016/0198-8859(94)90042-6; RA Ogawa A., Tokunaga K., Nakajima F., Kikuchi A., Karaki S., RA Kashiwase K., Ge J., Hannestad K., Juji T., Takiguchi M.; RT "Identification of the gene encoding a novel HLA-B39 subtype. Two RT amino acid substitutions on the beta-sheet out of the peptide-binding RT floor form a novel serological epitope."; RL Hum. Immunol. 41:241-247(1994). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*39:09). RC TISSUE=Blood; RX PubMed=8838352; DOI=10.1111/j.1399-0039.1995.tb03135.x; RA Ramos M., Postigo J.M., Vilches C., Layrisse Z., Lopez de Castro J.A.; RT "Primary structure of a novel HLA-B39 allele (B*3909) from the Warao RT Indians of Venezuela. Further evidence for local HLA-B diversification RT in South America."; RL Tissue Antigens 46:401-404(1995). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*39:06). RX PubMed=8795147; DOI=10.1111/j.1399-0039.1996.tb02582.x; RA Zhao W., Fernandez-Vina M.A., Lazaro A.M., Araujo H.A., Miller S., RA Stastny P.; RT "Full cDNA of a novel HLA-B39 subtype, B*39061."; RL Tissue Antigens 47:435-437(1996). RN [6] RP NUCLEOTIDE SEQUENCE (ALLELE B*39:06). RA Zhang L., Ellexson M.E., Hildebrand W.H.; RL Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*39:10). RX PubMed=8988545; DOI=10.1111/j.1399-0039.1996.tb02676.x; RA Wells R.S., Parham P.; RT "A novel recombinant HLA-B*39 allele (B*3910) in a South African RT Zulu."; RL Tissue Antigens 48:595-597(1996). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*39:10). RX PubMed=9234488; DOI=10.1111/j.1399-0039.1997.tb02814.x; RA Vilches C., Bunce M., de Pablo R., Moreno M.E., Puente S., Sanz L., RA Kreisler M.; RT "The novel HLA-Cw*1802 allele is associated with B*5703 in the Bubi RT population from Equatorial Guinea."; RL Tissue Antigens 49:644-648(1997). RN [9] RP NUCLEOTIDE SEQUENCE (ALLELE B*39:01). RA Kashiwase K.; RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*39:24). RC TISSUE=Peripheral blood; RX PubMed=12558815; DOI=10.1046/j.1365-2370.2003.00362.x; RA Estefania E., Gomez-Lozano N., de Pablo R., Moreno M.E., Vilches C.; RT "Complementary DNA sequence of the HLA-B*3924 allele."; RL Eur. J. Immunogenet. 30:11-12(2003). RN [11] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-362 (ALLELE B*39:08). RX PubMed=8838356; DOI=10.1111/j.1399-0039.1995.tb03139.x; RA Adams E.J., Little A.-M., Arnett K.L., McAuley J.E., Williams R.C., RA Parham P.; RT "Three new HLA-B alleles found in Mexican-Americans."; RL Tissue Antigens 46:414-416(1995). RN [12] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*39:12). RX PubMed=10372543; DOI=10.1034/j.1399-0039.1999.530504.x; RA Marcos C.Y., Fernandez-Vina M.A., Lazaro A.M., Moraes M.E., RA Moraes J.R., Stastny P.; RT "Novel HLA-A and HLA-B alleles in South American Indians."; RL Tissue Antigens 53:476-485(1999). RN [13] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*39:12). RX PubMed=10600013; DOI=10.1016/S0198-8859(99)00092-0; RA Lazaro A.M., Moraes M.E., Marcos C.Y., Moraes J.R., RA Fernandez-Vina M.A., Stastny P.; RT "Evolution of HLA-class I compared to HLA-class II polymorphism in RT Terena, a South-American Indian tribe."; RL Hum. Immunol. 60:1138-1149(1999). RN [14] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*39:23). RX PubMed=11260515; DOI=10.1034/j.1399-0039.2001.057002169.x; RA Akesaka T., Kashiwase K., Ishikawa Y., Tanaka H., Shimizu M., RA Kawai S., Akaza T., Takahashi T., Juji T.; RT "Allele frequency of HLA-B39 in the Japanese population and RT identification of a novel B39 allele, B*3923."; RL Tissue Antigens 57:169-172(2001). RN [15] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-196 (ALLELE B*39:07). RX PubMed=7797264; DOI=10.1007/BF00164983; RA Garber T.L., Butler L.M., Trachtenberg E.A., Erlich H.A., Rickards O., RA De Stefano G., Watkins D.I.; RT "HLA-B alleles of the Cayapa of Ecuador: new B39 and B15 alleles."; RL Immunogenetics 42:19-27(1995). RN [16] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [17] RP VARIANT [LARGE SCALE ANALYSIS] THR-65, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [18] RP VARIANT [LARGE SCALE ANALYSIS] GLU-87, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-39 are known: B*39:01 CC (B39.1), B*39:02 (B9.2), B*39:03, B*39:04 (B39N), B*39:05 (ST-16), CC B*39:06 (B39G), B*39:07 (B39uw3), B*39:09, B*39:10, B*39:12 CC (B3901v), B*39:23 (B39022v1) and B*39:24. The sequence shown is CC that of B*39:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M94052; AAA52658.1; -; Genomic_DNA. DR EMBL; M94051; AAA52660.1; -; Genomic_DNA. DR EMBL; M94053; AAA52659.1; -; Genomic_DNA. DR EMBL; U04243; AAA87396.1; -; mRNA. DR EMBL; L36318; AAA73942.1; -; mRNA. DR EMBL; L22649; AAA69861.1; -; Genomic_DNA. DR EMBL; U29480; AAC50392.1; -; mRNA. DR EMBL; L42024; AAB59484.1; -; mRNA. DR EMBL; U29083; AAC32741.1; -; mRNA. DR EMBL; U56246; AAB01985.1; -; Genomic_DNA. DR EMBL; Y09058; CAA70261.1; -; mRNA. DR EMBL; AB091216; BAC11810.1; -; Genomic_DNA. DR EMBL; AB091218; BAC11811.1; -; Genomic_DNA. DR EMBL; AF428252; AAN63555.1; -; mRNA. DR EMBL; L42280; AAB51452.1; -; Genomic_DNA. DR EMBL; AH004887; AAB39108.1; -; Genomic_DNA. DR EMBL; AB032097; BAA84116.1; -; Genomic_DNA. DR EMBL; U15640; AAA74047.1; -; Genomic_DNA. DR PIR; I38876; I38876. DR PIR; I54314; I54314. DR PIR; I54505; I54505. DR PIR; I68850; I68850. DR PIR; I84488; I84488. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 4O2C; X-ray; 1.80 A; A=25-298. DR PDB; 4O2E; X-ray; 1.98 A; A/D=25-298. DR PDB; 4O2F; X-ray; 1.90 A; A/D=25-298. DR PDBsum; 4O2C; -. DR PDBsum; 4O2E; -. DR PDBsum; 4O2F; -. DR ProteinModelPortal; P30475; -. DR SMR; P30475; -. DR SwissPalm; P30475; -. DR DMDM; 231398; -. DR MaxQB; P30475; -. DR PeptideAtlas; P30475; -. DR PRIDE; P30475; -. DR Ensembl; ENST00000425848; ENSP00000400842; ENSG00000223532. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30475; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-39 alpha chain. FT /FTId=PRO_0000018843. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 4 4 M -> T (in dbSNP:rs1050458). FT /FTId=VAR_056355. FT VARIANT 9 9 V -> L (in dbSNP:rs1050462). FT /FTId=VAR_056356. FT VARIANT 17 17 L -> V (in dbSNP:rs1131165). FT /FTId=VAR_056357. FT VARIANT 33 33 Y -> D (in allele B*39:12). FT /FTId=VAR_016659. FT VARIANT 35 35 S -> A (in allele B*39:04 and allele FT B*39:12; dbSNP:rs1131170). FT /FTId=VAR_016421. FT VARIANT 36 36 V -> M (in allele B*39:04; FT dbSNP:rs1050486). FT /FTId=VAR_016660. FT VARIANT 48 48 S -> A (in dbSNP:rs713031). FT /FTId=VAR_061410. FT VARIANT 48 48 S -> P (in dbSNP:rs713031). FT /FTId=VAR_061411. FT VARIANT 48 48 S -> T (in dbSNP:rs713031). FT /FTId=VAR_061412. FT VARIANT 65 65 A -> T (in dbSNP:rs1050529). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056358. FT VARIANT 87 87 N -> D (in dbSNP:rs1050570). FT /FTId=VAR_056359. FT VARIANT 87 87 N -> E (in allele B*39:02, allele B*39:08 FT and allele B*39:23; requires 2 nucleotide FT substitutions). FT {ECO:0000244|PubMed:24275569}. FT /FTId=VAR_016422. FT VARIANT 87 87 N -> K (in dbSNP:rs1065386). FT /FTId=VAR_059479. FT VARIANT 91 91 C -> S (in allele B*39:02, allele B*39:08 FT and allele B*39:23). FT /FTId=VAR_016423. FT VARIANT 91 91 C -> Y (in allele B*39:10). FT /FTId=VAR_016424. FT VARIANT 97 97 T -> A (in dbSNP:rs1050393). FT /FTId=VAR_056360. FT VARIANT 98 98 D -> Y (in allele B*39:05, allele B*39:07 FT and allele B*39:08; dbSNP:rs1131215). FT /FTId=VAR_016425. FT VARIANT 119 119 L -> W (in allele B*39:06). FT /FTId=VAR_016426. FT VARIANT 121 121 R -> S (in allele B*39:03 and allele FT B*39:24). FT /FTId=VAR_016427. FT VARIANT 121 121 R -> T (in allele B*39:06). FT /FTId=VAR_016428. FT VARIANT 122 122 M -> T (in allele B*39:24). FT /FTId=VAR_016429. FT VARIANT 123 123 Y -> S (in allele B*39:09). FT /FTId=VAR_016430. FT VARIANT 138 138 N -> D (in allele B*39:07). FT /FTId=VAR_016431. FT VARIANT 140 140 F -> S (in allele B*39:07). FT /FTId=VAR_016432. FT VARIANT 168 168 Q -> R (in allele B*39:23). FT /FTId=VAR_016433. FT VARIANT 180 180 L -> R (in allele B*39:08). FT /FTId=VAR_016434. FT VARIANT 306 306 V -> I (in dbSNP:rs1131500). FT /FTId=VAR_056361. FT VARIANT 329 329 A -> T (in dbSNP:rs1051488). FT /FTId=VAR_056362. FT STRAND 27 36 {ECO:0000244|PDB:4O2C}. FT STRAND 41 43 {ECO:0000244|PDB:4O2C}. FT STRAND 45 52 {ECO:0000244|PDB:4O2C}. FT STRAND 55 61 {ECO:0000244|PDB:4O2C}. FT STRAND 64 66 {ECO:0000244|PDB:4O2C}. FT HELIX 74 76 {ECO:0000244|PDB:4O2C}. FT HELIX 81 108 {ECO:0000244|PDB:4O2C}. FT STRAND 113 115 {ECO:0000244|PDB:4O2F}. FT STRAND 118 127 {ECO:0000244|PDB:4O2C}. FT STRAND 133 142 {ECO:0000244|PDB:4O2C}. FT STRAND 145 150 {ECO:0000244|PDB:4O2C}. FT STRAND 157 161 {ECO:0000244|PDB:4O2C}. FT HELIX 162 173 {ECO:0000244|PDB:4O2C}. FT HELIX 176 185 {ECO:0000244|PDB:4O2C}. FT HELIX 187 198 {ECO:0000244|PDB:4O2C}. FT HELIX 200 203 {ECO:0000244|PDB:4O2C}. FT STRAND 210 217 {ECO:0000244|PDB:4O2C}. FT STRAND 219 235 {ECO:0000244|PDB:4O2C}. FT STRAND 238 243 {ECO:0000244|PDB:4O2C}. FT HELIX 249 251 {ECO:0000244|PDB:4O2C}. FT STRAND 252 254 {ECO:0000244|PDB:4O2E}. FT STRAND 261 263 {ECO:0000244|PDB:4O2C}. FT STRAND 265 274 {ECO:0000244|PDB:4O2C}. FT HELIX 278 280 {ECO:0000244|PDB:4O2C}. FT STRAND 281 286 {ECO:0000244|PDB:4O2C}. FT STRAND 290 292 {ECO:0000244|PDB:4O2F}. FT STRAND 294 296 {ECO:0000244|PDB:4O2C}. SQ SEQUENCE 362 AA; 40328 MW; 422698063DEAB039 CRC64; MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI CKTNTQTDRE SLRNLRGYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHNQF AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RTYLEGTCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B40_HUMAN Reviewed; 362 AA. AC Q04826; O19556; O19651; P01890; P30477; P30478; Q29762; Q29842; AC Q29855; Q30173; Q31603; Q9TPT6; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1993, sequence version 1. DT 12-SEP-2018, entry version 150. DE RecName: Full=HLA class I histocompatibility antigen, B-40 alpha chain; DE AltName: Full=Bw-60; DE AltName: Full=MHC class I antigen B*40; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE B*40:01). RX PubMed=2437025; DOI=10.1007/BF00404425; RA Ways J.W., Lawlor D.A., Wan A.M., Parham P.; RT "A transposable epitope of HLA-B7, B40 molecules."; RL Immunogenetics 25:323-328(1987). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*40:01). RX PubMed=7517584; DOI=10.1111/j.1399-0039.1994.tb02294.x; RA Little A.-M., Domena J.D., Hildebrand W.H., Shen S.Y., Barber L.D., RA Marsh S.G.E., Bias W.B., Parham P.; RT "HLA-B67: a member of the HLA-B16 family that expresses the ME1 RT epitope."; RL Tissue Antigens 43:38-43(1994). RN [3] RP PROTEIN SEQUENCE OF 25-295 (B*40:01). RX PubMed=6193808; DOI=10.1021/bi00285a036; RA Lopez de Castro J.A., Bragado R., Strong D.M., Strominger J.L.; RT "Primary structure of papain-solubilized human histocompatibility RT antigen HLA-B40 (-Bw60). An outline of alloantigenic determinants."; RL Biochemistry 22:3961-3969(1983). RN [4] RP NUCLEOTIDE SEQUENCE (ALLELE B*40:02). RX PubMed=1362296; DOI=10.1111/j.1399-0039.1992.tb02053.x; RA Domena J.D., Johnston-Dow L., Parham P.; RT "The B*4002 allele encodes the B61 antigen: B40* is identical to RT B61."; RL Tissue Antigens 40:254-256(1992). RN [5] RP NUCLEOTIDE SEQUENCE OF 13-318 (ALLELE B*40:02). RC TISSUE=Blood; RX PubMed=1481202; DOI=10.1111/j.1399-0039.1992.tb02054.x; RA Lin L., Watanabe Y., Tokunaga K., Kuwata S., Kohsaka T., Akaza T.; RT "A common Japanese haplotype HLA-A26-Cw3-B61-DR9-DQ3 carries HLA- RT B*4002."; RL Tissue Antigens 40:257-260(1992). RN [6] RP NUCLEOTIDE SEQUENCE (ALLELES B*40:03 AND B*40:04). RX PubMed=1317015; DOI=10.1038/357326a0; RA Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J., RA Williams R.C., Luz R., Petzl-Erler M.L., Parham P.; RT "Unusual HLA-B alleles in two tribes of Brazilian Indians."; RL Nature 357:326-329(1992). RN [7] RP NUCLEOTIDE SEQUENCE (ALLELE B*40:05). RX PubMed=1385528; RA Hildebrand W.H., Madrigal J.A., Belich M.P., Zemmour J., Ward F.E., RA Williams R.C., Parham P.; RT "Serologic cross-reactivities poorly reflect allelic relationships in RT the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 RT helix."; RL J. Immunol. 149:3563-3568(1992). RN [8] RP NUCLEOTIDE SEQUENCE (ALLELE B*40:06). RA Herrero M.J.; RL Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE (ALLELE B*40:06). RC TISSUE=Blood; RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [10] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*40:08). RX PubMed=8525480; DOI=10.1111/j.1399-0039.1995.tb03120.x; RA Adams E.J., Little A.-M., Arnett K.L., Leushner J., Parham P.; RT "Identification of a novel HLA-B40 allele (B*4008) in a patient with RT leukemia."; RL Tissue Antigens 46:204-205(1995). RN [11] RP NUCLEOTIDE SEQUENCE [MRNA] OF 26-206 (ALLELE B*40:09). RX PubMed=10372543; DOI=10.1034/j.1399-0039.1999.530504.x; RA Marcos C.Y., Fernandez-Vina M.A., Lazaro A.M., Moraes M.E., RA Moraes J.R., Stastny P.; RT "Novel HLA-A and HLA-B alleles in South American Indians."; RL Tissue Antigens 53:476-485(1999). RN [12] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*40:16). RX PubMed=11098929; DOI=10.1034/j.1399-0039.2000.560401.x; RA Ellis J.M., Mack S.J., Leke R.F.G., Quakyi I., Johnson A.H., RA Hurley C.K.; RT "Diversity is demonstrated in class I HLA-A and HLA-B alleles in RT Cameroon, Africa: description of HLA-A*03012, *2612, *3006 and HLA- RT B*1403, *4016, *4703."; RL Tissue Antigens 56:291-302(2000). RN [13] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*40:27). RA Pimtanothai N., Hurley C.K.; RT "Novel HLA-B allele."; RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases. RN [14] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [15] RP VARIANT [LARGE SCALE ANALYSIS] ASP-138, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [16] RP VARIANT [LARGE SCALE ANALYSIS] SER-155, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-40 are known: B*40:01, CC B*40:02, B*40:03 (B40-G1), B*40:04 (B40-G2), B*40:05 (BN21), CC B*40:06, B*40:08, B*40:09, B*40:16 and B*40:27. The sequence shown CC is that of B*40:02. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; U03698; AAA03719.1; -; mRNA. DR EMBL; L41628; AAA65040.1; -; Genomic_DNA. DR EMBL; L09736; AAA36224.1; -; mRNA. DR EMBL; D14343; BAA03277.1; -; mRNA. DR EMBL; M84383; AAA59633.1; -; mRNA. DR EMBL; M84384; AAA59634.1; -; mRNA. DR EMBL; M84694; AAA03661.1; -; mRNA. DR EMBL; X84725; CAA59215.1; -; mRNA. DR EMBL; AJ300180; CAC15501.1; -; Genomic_DNA. DR EMBL; AJ292253; CAC29021.1; -; Genomic_DNA. DR EMBL; L41353; AAC41923.1; -; Genomic_DNA. DR EMBL; L76934; AAA96270.1; -; mRNA. DR EMBL; AH005563; AAB70252.1; -; Genomic_DNA. DR EMBL; AH008232; AAD56943.1; -; Genomic_DNA. DR PIR; I38437; HLHU40. DR PIR; I56149; I56149. DR PIR; I59655; I59655. DR PIR; I61905; I61905. DR PIR; I61906; I61906. DR PIR; S52486; S52486. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 5IEH; X-ray; 1.50 A; A=25-300. DR PDB; 5IEK; X-ray; 1.80 A; A=25-300. DR PDBsum; 5IEH; -. DR PDBsum; 5IEK; -. DR ProteinModelPortal; Q04826; -. DR SMR; Q04826; -. DR SwissPalm; Q04826; -. DR DMDM; 416557; -. DR EPD; Q04826; -. DR MaxQB; Q04826; -. DR PeptideAtlas; Q04826; -. DR PRIDE; Q04826; -. DR Ensembl; ENST00000359635; ENSP00000352656; ENSG00000206450. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_Q04826; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Direct protein sequencing; KW Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I; Polymorphism; KW Reference proteome; Signal; Transmembrane; Transmembrane helix; KW Ubl conjugation. FT SIGNAL 1 24 {ECO:0000269|PubMed:6193808}. FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-40 alpha chain. FT /FTId=PRO_0000018844. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT DISULFID 125 188 FT DISULFID 227 283 FT VARIANT 9 9 L -> V (in allele B*40:01). FT /FTId=VAR_016435. FT VARIANT 14 15 WG -> SA (in allele B*40:01). FT /FTId=VAR_016436. FT VARIANT 17 17 V -> L (in allele B*40:01). FT /FTId=VAR_016437. FT VARIANT 35 36 SV -> AM (in allele B*40:01 and allele FT B*40:16). FT /FTId=VAR_016438. FT VARIANT 87 87 E -> N (in allele B*40:08; requires 2 FT nucleotide substitutions). FT /FTId=VAR_016439. FT VARIANT 91 91 S -> F (in allele B*40:08). FT /FTId=VAR_016440. FT VARIANT 101 101 S -> N (in dbSNP:rs1050388). FT /FTId=VAR_056363. FT VARIANT 118 119 TL -> II (in allele B*40:03). FT /FTId=VAR_016441. FT VARIANT 119 119 L -> W (in allele B*40:06). FT /FTId=VAR_016442. FT VARIANT 121 121 S -> R (in allele B*40:01 and allele FT B*40:03). FT /FTId=VAR_016443. FT VARIANT 121 121 S -> T (in allele B*40:06). FT /FTId=VAR_016444. FT VARIANT 127 127 V -> L (in allele B*40:03). FT /FTId=VAR_016445. FT VARIANT 137 137 H -> Y (in allele B*40:09; FT dbSNP:rs1050379). FT /FTId=VAR_016658. FT VARIANT 138 138 N -> D (in allele B*40:04 and allele FT B*40:09). {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_016446. FT VARIANT 140 140 Y -> N (in allele B*40:27). FT /FTId=VAR_016447. FT VARIANT 140 140 Y -> S (in allele B*40:04). FT /FTId=VAR_016448. FT VARIANT 155 155 R -> S (in dbSNP:rs1050654). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_056364. FT VARIANT 167 167 T -> S (in allele B*40:01). FT /FTId=VAR_016449. FT VARIANT 171 171 W -> L (in allele B*40:01). FT /FTId=VAR_016450. FT VARIANT 176 176 V -> E (in allele B*40:05 and allele FT B*40:16). FT /FTId=VAR_016451. FT VARIANT 180 180 L -> R (in allele B*40:16). FT /FTId=VAR_016655. FT VARIANT 187 187 E -> L (in allele B*40:05; requires 2 FT nucleotide substitutions). FT /FTId=VAR_016452. FT VARIANT 201 202 ET -> DK (in allele B*40:01 and allele FT B*40:16). FT /FTId=VAR_016453. FT VARIANT 204 204 Q -> E (in allele B*40:01 and allele FT B*40:16). FT /FTId=VAR_016454. FT VARIANT 306 306 V -> I (in dbSNP:rs1131500). FT /FTId=VAR_056365. FT VARIANT 329 329 A -> T (in dbSNP:rs1051488). FT /FTId=VAR_056366. FT VARIANT 349 349 C -> S (in dbSNP:rs2308655). FT /FTId=VAR_061413. FT VARIANT 349 349 C -> Y (in dbSNP:rs2308655). FT /FTId=VAR_061414. FT CONFLICT 167 167 Missing (in Ref. 3; AA sequence). FT {ECO:0000305}. FT STRAND 27 36 {ECO:0000244|PDB:5IEH}. FT STRAND 41 43 {ECO:0000244|PDB:5IEK}. FT STRAND 45 52 {ECO:0000244|PDB:5IEH}. FT STRAND 55 61 {ECO:0000244|PDB:5IEH}. FT STRAND 64 66 {ECO:0000244|PDB:5IEH}. FT HELIX 74 76 {ECO:0000244|PDB:5IEH}. FT HELIX 81 108 {ECO:0000244|PDB:5IEH}. FT STRAND 118 127 {ECO:0000244|PDB:5IEH}. FT STRAND 133 142 {ECO:0000244|PDB:5IEH}. FT STRAND 145 150 {ECO:0000244|PDB:5IEH}. FT STRAND 157 161 {ECO:0000244|PDB:5IEH}. FT HELIX 162 173 {ECO:0000244|PDB:5IEH}. FT HELIX 176 185 {ECO:0000244|PDB:5IEH}. FT HELIX 187 198 {ECO:0000244|PDB:5IEH}. FT HELIX 200 203 {ECO:0000244|PDB:5IEH}. FT STRAND 210 217 {ECO:0000244|PDB:5IEH}. FT STRAND 219 235 {ECO:0000244|PDB:5IEH}. FT STRAND 238 243 {ECO:0000244|PDB:5IEH}. FT HELIX 249 251 {ECO:0000244|PDB:5IEH}. FT STRAND 261 263 {ECO:0000244|PDB:5IEH}. FT STRAND 265 274 {ECO:0000244|PDB:5IEH}. FT HELIX 278 280 {ECO:0000244|PDB:5IEH}. FT STRAND 281 286 {ECO:0000244|PDB:5IEH}. FT STRAND 294 296 {ECO:0000244|PDB:5IEH}. SQ SEQUENCE 362 AA; 40505 MW; 7D66503ACD865152 CRC64; MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFHTSVSRPG RGEPRFITVG YVDDTLFVRF DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARVAEQL RAYLEGECVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA // ID 1B41_HUMAN Reviewed; 362 AA. AC P30479; O19595; Q29848; Q5TK77; Q9MY79; Q9MY94; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 148. DE RecName: Full=HLA class I histocompatibility antigen, B-41 alpha chain; DE AltName: Full=Bw-41; DE AltName: Full=MHC class I antigen B*41; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE B*41:01). RX PubMed=2715640; RA Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.; RT "Diversity and diversification of HLA-A,B,C alleles."; RL J. Immunol. 142:3937-3950(1989). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Blood; RA Cox S.T.; RT "Confirmation of B*4101."; RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*41:02). RX PubMed=7721359; DOI=10.1007/BF00172162; RA Rufer N., Roosnek E., Kressig R., Jeannet M., Tiercy J.-M.; RT "Sequencing of a new HLA-B41 subtype (B*4102) that occurs with a high RT frequency in the Caucasoid population."; RL Immunogenetics 41:333-333(1995). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*41:03). RX PubMed=9714480; DOI=10.1111/j.1399-0039.1998.tb03029.x; RA Hurley C.K., Steiner N.K., Kosman C., Mitton W., Koester R., Bei M., RA Bush J., McCormack J., Hahn A., Henson V., Hoyer R., Wade J.A., RA Hartzman R.J., Ng J.; RT "Novel HLA-A and HLA-B alleles."; RL Tissue Antigens 52:84-87(1998). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*41:04). RX PubMed=11169265; DOI=10.1034/j.1399-0039.2001.057001083.x; RA Turner D.M., Vlachos G., Cavanna S.L., Brown J., Brown C., RA Navarrete C.V.; RT "A novel HLA allele, B*4104, identified in a cord blood donor."; RL Tissue Antigens 57:83-84(2001). RN [6] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*41:05). RA Gans C.P., Hurley C.K.; RT "Novel HLA-B allele."; RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases. RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [8] RP X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 25-298, AND DISULFIDE BONDS. RX PubMed=20934997; DOI=10.3324/haematol.2010.030924; RA Bade-Doding C., Theodossis A., Gras S., Kjer-Nielsen L., RA Eiz-Vesper B., Seltsam A., Huyton T., Rossjohn J., McCluskey J., RA Blasczyk R.; RT "The impact of human leukocyte antigen (HLA) micropolymorphism on RT ligand specificity within the HLA-B*41 allotypic family."; RL Haematologica 96:110-118(2011). RN [9] RP VARIANT [LARGE SCALE ANALYSIS] ASP-138, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [10] RP VARIANT [LARGE SCALE ANALYSIS] SER-155, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-41 are known: B*41:01, CC B*41:02 (B41.2), B*41:03, B*41:04 and B*41:05. The sequence shown CC is that of B*41:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M24035; AAA59666.1; -; Genomic_DNA. DR EMBL; AJ309193; CAC38392.1; -; Genomic_DNA. DR EMBL; X81363; CAA57128.1; -; mRNA. DR EMBL; AH006381; AAC33187.1; -; Genomic_DNA. DR EMBL; AF258782; AAF76144.1; -; Genomic_DNA. DR EMBL; AH009589; AAF81603.1; -; Genomic_DNA. DR PIR; I37492; I37492. DR PIR; I61864; I61864. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 3LN4; X-ray; 1.30 A; A=25-298. DR PDB; 3LN5; X-ray; 1.90 A; A=25-298. DR PDBsum; 3LN4; -. DR PDBsum; 3LN5; -. DR ProteinModelPortal; P30479; -. DR SMR; P30479; -. DR SwissPalm; P30479; -. DR DMDM; 231402; -. DR EPD; P30479; -. DR MaxQB; P30479; -. DR PeptideAtlas; P30479; -. DR PRIDE; P30479; -. DR Ensembl; ENST00000425848; ENSP00000400842; ENSG00000223532. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30479; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR EvolutionaryTrace; P30479; -. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-41 alpha chain. FT /FTId=PRO_0000018845. FT TOPO_DOM 25 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:20934997}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:20934997}. FT VARIANT 9 9 V -> L (in dbSNP:rs1050462). FT /FTId=VAR_056367. FT VARIANT 17 17 L -> V (in dbSNP:rs1131165). FT /FTId=VAR_056368. FT VARIANT 104 104 N -> K (in allele B*41:05). FT /FTId=VAR_016459. FT VARIANT 119 119 W -> L (in allele B*41:02, allele B*41:03 FT and allele B*41:04). FT /FTId=VAR_016455. FT VARIANT 121 121 R -> S (in allele B*41:02 and allele FT B*41:04). FT /FTId=VAR_016456. FT VARIANT 127 127 V -> L (in allele B*41:04). FT /FTId=VAR_016457. FT VARIANT 138 138 N -> D (in allele B*41:04). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_016458. FT VARIANT 155 155 R -> S (in dbSNP:rs1050654). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_056369. FT VARIANT 306 306 V -> I (in dbSNP:rs1131500). FT /FTId=VAR_056370. FT VARIANT 329 329 A -> T (in dbSNP:rs1051488). FT /FTId=VAR_056371. FT VARIANT 349 349 C -> S (in dbSNP:rs2308655). FT /FTId=VAR_061415. FT VARIANT 349 349 C -> Y (in dbSNP:rs2308655). FT /FTId=VAR_061416. FT STRAND 27 36 {ECO:0000244|PDB:3LN4}. FT STRAND 45 52 {ECO:0000244|PDB:3LN4}. FT STRAND 55 61 {ECO:0000244|PDB:3LN4}. FT STRAND 64 66 {ECO:0000244|PDB:3LN4}. FT HELIX 74 76 {ECO:0000244|PDB:3LN4}. FT HELIX 81 108 {ECO:0000244|PDB:3LN4}. FT STRAND 113 115 {ECO:0000244|PDB:3LN5}. FT STRAND 118 127 {ECO:0000244|PDB:3LN4}. FT STRAND 133 142 {ECO:0000244|PDB:3LN4}. FT STRAND 145 150 {ECO:0000244|PDB:3LN4}. FT STRAND 157 161 {ECO:0000244|PDB:3LN4}. FT HELIX 162 173 {ECO:0000244|PDB:3LN4}. FT HELIX 176 185 {ECO:0000244|PDB:3LN4}. FT HELIX 187 198 {ECO:0000244|PDB:3LN4}. FT HELIX 200 203 {ECO:0000244|PDB:3LN4}. FT STRAND 210 235 {ECO:0000244|PDB:3LN4}. FT STRAND 238 243 {ECO:0000244|PDB:3LN4}. FT TURN 249 251 {ECO:0000244|PDB:3LN4}. FT STRAND 261 263 {ECO:0000244|PDB:3LN4}. FT STRAND 265 274 {ECO:0000244|PDB:3LN4}. FT HELIX 278 280 {ECO:0000244|PDB:3LN4}. FT STRAND 281 286 {ECO:0000244|PDB:3LN4}. FT STRAND 294 296 {ECO:0000244|PDB:3LN4}. SQ SEQUENCE 362 AA; 40539 MW; 7443DC40CF7A38F5 CRC64; MRVTAPRTVL LLLSAALALT ETWAGSHSMR YFHTAMSRPG RGEPRFITVG YVDDTLFVRF DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE SLRNLRGYYN QSEAGSHTWQ RMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARVAEQD RAYLEGTCVE WLRRYLENGK DTLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA // ID 1B42_HUMAN Reviewed; 362 AA. AC P30480; P79555; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 155. DE RecName: Full=HLA class I histocompatibility antigen, B-42 alpha chain; DE AltName: Full=MHC class I antigen B*42; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE B*42:01). RX PubMed=2715640; RA Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.; RT "Diversity and diversification of HLA-A,B,C alleles."; RL J. Immunol. 142:3937-3950(1989). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*42:02). RX PubMed=9243763; DOI=10.1111/j.1399-0039.1997.tb02841.x; RA Lardy N.M., Otting N., van de Weerd M.J., van de Horst A.R., RA Waal L.P., Bontrop R.E.; RT "Full-length cDNA nucleotide sequence of the HLA-B*4202 allele."; RL Tissue Antigens 50:83-84(1997). RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE B*42:01). RC TISSUE=Blood; RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [4] RP VARIANT [LARGE SCALE ANALYSIS] THR-65, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] RP VARIANT [LARGE SCALE ANALYSIS] SER-155, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-42 are known: B*42:01 CC (Bw-42) and B*42:02. The sequence shown is that of B*42:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M24034; AAA59667.1; -; Genomic_DNA. DR EMBL; U88407; AAC16437.1; -; mRNA. DR EMBL; AJ309194; CAC38393.1; -; Genomic_DNA. DR PIR; I61865; I61865. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 4U1J; X-ray; 1.38 A; A=25-301. DR PDB; 4U1M; X-ray; 1.18 A; A=25-301. DR PDB; 4U1N; X-ray; 1.77 A; A=25-301. DR PDBsum; 4U1J; -. DR PDBsum; 4U1M; -. DR PDBsum; 4U1N; -. DR ProteinModelPortal; P30480; -. DR SMR; P30480; -. DR IntAct; P30480; 26. DR SwissPalm; P30480; -. DR DMDM; 231403; -. DR EPD; P30480; -. DR PeptideAtlas; P30480; -. DR PRIDE; P30480; -. DR Ensembl; ENST00000412585; ENSP00000399168; ENSG00000234745. DR DisGeNET; 3106; -. DR EuPathDB; HostDB:ENSG00000234745.9; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR HPA; CAB015418; -. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30480; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000234745; Expressed in 92 organ(s), highest expression level in blood. DR CleanEx; HS_HLA-B; -. DR ExpressionAtlas; P30480; baseline and differential. DR Genevisible; P30480; HS. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-42 alpha chain. FT /FTId=PRO_0000018846. FT TOPO_DOM 25 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 4 4 M -> T (in dbSNP:rs1050458). FT /FTId=VAR_056372. FT VARIANT 9 9 V -> L (in dbSNP:rs1050462). FT /FTId=VAR_056373. FT VARIANT 17 17 L -> V (in dbSNP:rs1131165). FT /FTId=VAR_056374. FT VARIANT 33 33 Y -> H (in allele B*42:02). FT /FTId=VAR_016460. FT VARIANT 35 35 S -> A (in dbSNP:rs1131170). FT /FTId=VAR_056375. FT VARIANT 36 36 V -> M (in dbSNP:rs1050486). FT /FTId=VAR_056376. FT VARIANT 48 48 S -> A (in dbSNP:rs713031). FT /FTId=VAR_061417. FT VARIANT 48 48 S -> P (in dbSNP:rs713031). FT /FTId=VAR_061418. FT VARIANT 48 48 S -> T (in dbSNP:rs713031). FT /FTId=VAR_061419. FT VARIANT 65 65 A -> T (in dbSNP:rs1050529). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056377. FT VARIANT 87 87 N -> D (in dbSNP:rs1050570). FT /FTId=VAR_056378. FT VARIANT 87 87 N -> K (in dbSNP:rs1065386). FT /FTId=VAR_059480. FT VARIANT 97 97 T -> A (in dbSNP:rs1050393). FT /FTId=VAR_056379. FT VARIANT 98 98 D -> Y (in dbSNP:rs1131215). FT /FTId=VAR_059481. FT VARIANT 101 101 S -> N (in dbSNP:rs1050388). FT /FTId=VAR_056380. FT VARIANT 137 137 H -> Y (in dbSNP:rs1050379). FT /FTId=VAR_056381. FT VARIANT 155 155 R -> S (in dbSNP:rs1050654). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_056382. FT VARIANT 306 306 V -> I (in dbSNP:rs1131500). FT /FTId=VAR_056383. FT VARIANT 329 329 A -> T (in dbSNP:rs1051488). FT /FTId=VAR_056384. FT VARIANT 349 349 C -> S (in dbSNP:rs2308655). FT /FTId=VAR_061420. FT VARIANT 349 349 C -> Y (in dbSNP:rs2308655). FT /FTId=VAR_061421. FT STRAND 27 36 {ECO:0000244|PDB:4U1M}. FT STRAND 41 43 {ECO:0000244|PDB:4U1M}. FT STRAND 45 52 {ECO:0000244|PDB:4U1M}. FT STRAND 55 61 {ECO:0000244|PDB:4U1M}. FT STRAND 64 66 {ECO:0000244|PDB:4U1M}. FT HELIX 74 76 {ECO:0000244|PDB:4U1M}. FT HELIX 81 108 {ECO:0000244|PDB:4U1M}. FT STRAND 118 127 {ECO:0000244|PDB:4U1M}. FT STRAND 133 142 {ECO:0000244|PDB:4U1M}. FT STRAND 145 150 {ECO:0000244|PDB:4U1M}. FT STRAND 157 161 {ECO:0000244|PDB:4U1M}. FT HELIX 162 173 {ECO:0000244|PDB:4U1M}. FT HELIX 176 185 {ECO:0000244|PDB:4U1M}. FT HELIX 187 198 {ECO:0000244|PDB:4U1M}. FT HELIX 200 203 {ECO:0000244|PDB:4U1M}. FT STRAND 210 217 {ECO:0000244|PDB:4U1M}. FT STRAND 219 235 {ECO:0000244|PDB:4U1M}. FT STRAND 238 243 {ECO:0000244|PDB:4U1M}. FT HELIX 249 251 {ECO:0000244|PDB:4U1M}. FT STRAND 252 254 {ECO:0000244|PDB:4U1M}. FT STRAND 261 263 {ECO:0000244|PDB:4U1M}. FT STRAND 265 274 {ECO:0000244|PDB:4U1M}. FT HELIX 278 280 {ECO:0000244|PDB:4U1M}. FT STRAND 281 286 {ECO:0000244|PDB:4U1M}. FT STRAND 294 296 {ECO:0000244|PDB:4U1M}. SQ SEQUENCE 362 AA; 40333 MW; C9155AB015DEA1BE CRC64; MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARVAEQD RAYLEGTCVE WLRRYLENGK DTLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA // ID 1B44_HUMAN Reviewed; 362 AA. AC P30481; P10320; P30482; P79524; Q29850; Q5RIP1; Q860I4; Q861B5; AC Q9BCM7; Q9MYC3; Q9UQS8; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 162. DE RecName: Full=HLA class I histocompatibility antigen, B-44 alpha chain; DE AltName: Full=Bw-44; DE AltName: Full=MHC class I antigen B*44; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE B*44:02). RX PubMed=2715640; RA Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.; RT "Diversity and diversification of HLA-A,B,C alleles."; RL J. Immunol. 142:3937-3950(1989). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*44:03). RX PubMed=1871765; DOI=10.1111/j.1399-0039.1991.tb01859.x; RA Fleischhauer K., Kernan N.A., Dupont B., Yang S.Y.; RT "The two major subtypes of HLA-B44 differ for a single amino acid in RT codon 156."; RL Tissue Antigens 37:133-137(1991). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*44:03). RX PubMed=8838356; DOI=10.1111/j.1399-0039.1995.tb03139.x; RA Adams E.J., Little A.-M., Arnett K.L., McAuley J.E., Williams R.C., RA Parham P.; RT "Three new HLA-B alleles found in Mexican-Americans."; RL Tissue Antigens 46:414-416(1995). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*44:07). RX PubMed=8851728; DOI=10.1111/j.1399-0039.1996.tb02527.x; RA Vilches C., Sanz L., de Pablo R., Moreno M.E., Puente S., Kreisler M.; RT "Molecular characterization of the new alleles HLA-B*8101 and RT B*4407."; RL Tissue Antigens 47:139-142(1996). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*44:08). RX PubMed=9243752; DOI=10.1111/j.1399-0039.1997.tb02830.x; RA Darke C., Street J., Fussell H., Thomas M., Guttridge M., RA Goldberg T.E., Arnett K.L., Parham P.; RT "A new HLA-B44 variant (B44BO [B*4408]) identified by serology."; RL Tissue Antigens 50:32-37(1997). RN [6] RP NUCLEOTIDE SEQUENCE (ALLELE B*44:12). RA Cox S.T., McWhinnie A.J., Prokupek B., Madrigal A., Little A.-M.; RT "Further diversity within the HLA-B44 group: two novel alleles RT identified in UK Caucasoid potential bone marrow donors."; RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*44:13). RX PubMed=10746795; DOI=10.1034/j.1399-0039.2000.550215.x; RA Cox S.T., McWhinnie A.J., Prokupek B., Madrigal A., Little A.-M.; RT "HLA-B*4413 identified in a UK Caucasoid potential bone marrow RT donor."; RL Tissue Antigens 55:185-187(2000). RN [8] RP NUCLEOTIDE SEQUENCE (ALLELES B*44:02 AND B*44:09). RA Dunn P.P.J.; RT "Complete nucleotide sequencing of HLA class I genes."; RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE (ALLELE B*44:05). RA Vilches C., Sepulveda S.; RT "Complete cDNA sequence of HLA-B*4405."; RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE (ALLELE B*44:04). RC TISSUE=Blood; RA Cox S.T.; RT "Confirmation of HLA-B*4404."; RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases. RN [11] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [12] RP NUCLEOTIDE SEQUENCE [MRNA] OF 4-362 (ALLELE B*44:02). RX PubMed=3459708; DOI=10.1007/BF00372673; RA Kottmann A.H., Seemann G.H.A., Guessow H.D., Roos M.H.; RT "DNA sequence of the coding region of the HLA-B44 gene."; RL Immunogenetics 23:396-400(1986). RN [13] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [14] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [15] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [16] RP X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 25-300, AND DISULFIDE BONDS. RX PubMed=12939341; DOI=10.1084/jem.20030066; RA Macdonald W.A., Purcell A.W., Mifsud N.A., Ely L.K., Williams D.S., RA Chang L., Gorman J.J., Clements C.S., Kjer-Nielsen L., Koelle D.M., RA Burrows S.R., Tait B.D., Holdsworth R., Brooks A.G., Lovrecz G.O., RA Lu L., Rossjohn J., McCluskey J.; RT "A naturally selected dimorphism within the HLA-B44 supertype alters RT class I structure, peptide repertoire, and T cell recognition."; RL J. Exp. Med. 198:679-691(2003). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-44 are known: B*44:02 (B- CC 12; B44.2), B*44:04, B*44:05, B*44:07, B*44:08 (B44BO), B*44:09, CC B*44:12 and B*44:13. The sequence shown is that of B*44:02. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M24038; AAA59663.1; -; Genomic_DNA. DR EMBL; X64366; CAA45718.1; -; mRNA. DR EMBL; L42282; AAB51454.1; -; Genomic_DNA. DR EMBL; L42283; AAB51455.1; -; Genomic_DNA. DR EMBL; X90391; CAA62036.1; -; mRNA. DR EMBL; U64801; AAB40632.1; -; mRNA. DR EMBL; AJ133267; CAB38071.2; -; Genomic_DNA. DR EMBL; AJ131118; CAB37868.1; -; mRNA. DR EMBL; AJ309936; CAC33891.1; -; Genomic_DNA. DR EMBL; AJ309937; CAC33892.1; -; Genomic_DNA. DR EMBL; AJ535113; CAD59381.1; -; mRNA. DR EMBL; AJ550735; CAD79566.1; -; Genomic_DNA. DR EMBL; BX248310; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; M15470; AAA59619.1; -; mRNA. DR PIR; A25295; HLHUB4. DR PIR; I61861; I61861. DR PIR; S25415; S25415. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 1M6O; X-ray; 1.60 A; A=25-300. DR PDB; 1N2R; X-ray; 1.70 A; A=25-300. DR PDB; 1SYS; X-ray; 2.40 A; A=25-300. DR PDB; 1SYV; X-ray; 1.70 A; A=25-300. DR PDB; 3DX6; X-ray; 1.70 A; A=25-300. DR PDB; 3DX7; X-ray; 1.60 A; A=25-300. DR PDB; 3DX8; X-ray; 2.10 A; A=25-300. DR PDB; 3DXA; X-ray; 3.50 A; A/F/K=25-300. DR PDB; 3KPL; X-ray; 1.96 A; A=25-300. DR PDB; 3KPM; X-ray; 1.60 A; A=25-300. DR PDB; 3KPN; X-ray; 2.00 A; A=25-300. DR PDB; 3KPO; X-ray; 2.30 A; A=25-300. DR PDB; 3KPP; X-ray; 1.90 A; A=25-300. DR PDB; 3KPQ; X-ray; 1.84 A; A=25-300. DR PDB; 3KPR; X-ray; 2.60 A; A/F=25-300. DR PDB; 3KPS; X-ray; 2.70 A; A=25-300. DR PDB; 3L3D; X-ray; 1.80 A; A=25-300. DR PDB; 3L3G; X-ray; 2.10 A; A=25-300. DR PDB; 3L3I; X-ray; 1.70 A; A=25-300. DR PDB; 3L3J; X-ray; 2.40 A; A=25-300. DR PDB; 3L3K; X-ray; 2.60 A; A=25-300. DR PDB; 4JQX; X-ray; 1.90 A; A=25-302. DR PDBsum; 1M6O; -. DR PDBsum; 1N2R; -. DR PDBsum; 1SYS; -. DR PDBsum; 1SYV; -. DR PDBsum; 3DX6; -. DR PDBsum; 3DX7; -. DR PDBsum; 3DX8; -. DR PDBsum; 3DXA; -. DR PDBsum; 3KPL; -. DR PDBsum; 3KPM; -. DR PDBsum; 3KPN; -. DR PDBsum; 3KPO; -. DR PDBsum; 3KPP; -. DR PDBsum; 3KPQ; -. DR PDBsum; 3KPR; -. DR PDBsum; 3KPS; -. DR PDBsum; 3L3D; -. DR PDBsum; 3L3G; -. DR PDBsum; 3L3I; -. DR PDBsum; 3L3J; -. DR PDBsum; 3L3K; -. DR PDBsum; 4JQX; -. DR ProteinModelPortal; P30481; -. DR SMR; P30481; -. DR IntAct; P30481; 1. DR iPTMnet; P30481; -. DR SwissPalm; P30481; -. DR DMDM; 231404; -. DR EPD; P30481; -. DR MaxQB; P30481; -. DR PeptideAtlas; P30481; -. DR PRIDE; P30481; -. DR Ensembl; ENST00000421349; ENSP00000405365; ENSG00000228964. DR UCSC; uc011jij.3; human. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR H-InvDB; HIX0167415; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30481; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR PhylomeDB; P30481; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR EvolutionaryTrace; P30481; -. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-44 alpha chain. FT /FTId=PRO_0000018847. FT TOPO_DOM 25 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:12939341}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:12939341}. FT VARIANT 65 65 T -> A (in allele B*44:07 and allele FT B*44:08; dbSNP:rs1050529). FT /FTId=VAR_016461. FT VARIANT 69 70 KE -> MA (in allele B*44:08). FT /FTId=VAR_016462. FT VARIANT 85 85 D -> E (in allele B*44:13; FT dbSNP:rs151341165). FT /FTId=VAR_016463. FT VARIANT 87 87 E -> N (in allele B*44:12; requires 2 FT nucleotide substitutions). FT /FTId=VAR_016464. FT VARIANT 101 101 N -> S (in allele B*44:09; FT dbSNP:rs1050388). FT /FTId=VAR_016465. FT VARIANT 104 107 TALR -> NLRG (in allele B*44:09). FT /FTId=VAR_016466. FT VARIANT 140 140 D -> Y (in allele B*44:05; FT dbSNP:rs9266150). FT /FTId=VAR_016467. FT VARIANT 180 180 D -> L (in allele B*44:03, allele B*44:07 FT and allele B*44:13; requires 2 nucleotide FT substitutions). FT /FTId=VAR_016468. FT VARIANT 180 180 D -> R (in allele B*44:04; requires 2 FT nucleotide substitutions; FT dbSNP:rs376871308). FT /FTId=VAR_016469. FT VARIANT 187 187 L -> T (in allele B*44:04; requires 2 FT nucleotide substitutions; FT dbSNP:rs796093434). FT /FTId=VAR_016470. FT VARIANT 306 306 V -> I (in dbSNP:rs1131500). FT /FTId=VAR_056385. FT VARIANT 329 329 A -> T (in dbSNP:rs1051488). FT /FTId=VAR_056386. FT VARIANT 349 349 C -> S (in dbSNP:rs2308655). FT /FTId=VAR_061422. FT CONFLICT 106 106 L -> A (in Ref. 12; AAA59619). FT {ECO:0000305}. FT CONFLICT 223 223 V -> A (in Ref. 12; AAA59619). FT {ECO:0000305}. FT CONFLICT 229 229 A -> S (in Ref. 12; AAA59619). FT {ECO:0000305}. FT STRAND 27 36 {ECO:0000244|PDB:1M6O}. FT STRAND 41 43 {ECO:0000244|PDB:1M6O}. FT STRAND 45 52 {ECO:0000244|PDB:1M6O}. FT STRAND 55 61 {ECO:0000244|PDB:1M6O}. FT STRAND 64 66 {ECO:0000244|PDB:1M6O}. FT HELIX 74 76 {ECO:0000244|PDB:1M6O}. FT HELIX 81 108 {ECO:0000244|PDB:1M6O}. FT STRAND 113 115 {ECO:0000244|PDB:1N2R}. FT STRAND 118 127 {ECO:0000244|PDB:1M6O}. FT STRAND 129 132 {ECO:0000244|PDB:3DXA}. FT STRAND 133 142 {ECO:0000244|PDB:1M6O}. FT STRAND 145 150 {ECO:0000244|PDB:1M6O}. FT STRAND 157 161 {ECO:0000244|PDB:1M6O}. FT HELIX 162 173 {ECO:0000244|PDB:1M6O}. FT HELIX 176 185 {ECO:0000244|PDB:1M6O}. FT HELIX 187 198 {ECO:0000244|PDB:1M6O}. FT HELIX 200 203 {ECO:0000244|PDB:1M6O}. FT STRAND 210 219 {ECO:0000244|PDB:1M6O}. FT STRAND 222 235 {ECO:0000244|PDB:1M6O}. FT STRAND 238 243 {ECO:0000244|PDB:1M6O}. FT HELIX 249 251 {ECO:0000244|PDB:1M6O}. FT STRAND 252 254 {ECO:0000244|PDB:3KPM}. FT STRAND 261 263 {ECO:0000244|PDB:1M6O}. FT STRAND 265 274 {ECO:0000244|PDB:1M6O}. FT HELIX 278 280 {ECO:0000244|PDB:1M6O}. FT STRAND 281 286 {ECO:0000244|PDB:1M6O}. FT STRAND 290 292 {ECO:0000244|PDB:1M6O}. FT STRAND 294 296 {ECO:0000244|PDB:1M6O}. SQ SEQUENCE 362 AA; 40481 MW; E45C71FDEFC628AD CRC64; MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFITVG YVDDTLFVRF DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE NLRTALRYYN QSEAGSHIIQ RMYGCDVGPD GRLLRGYDQD AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQD RAYLEGLCVE SLRRYLENGK ETLQRADPPK THVTHHPISD HEVTLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA // ID 1B45_HUMAN Reviewed; 362 AA. AC P30483; Q9GIZ0; Q9MX21; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 144. DE RecName: Full=HLA class I histocompatibility antigen, B-45 alpha chain; DE AltName: Full=Bw-45; DE AltName: Full=MHC class I antigen B*45; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE B*45:01). RX PubMed=1431115; RA Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J., RA Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., RA Martell R.W., du Toit E.D., Parham P.; RT "Distinctive HLA-A,B antigens of black populations formed by RT interallelic conversion."; RL J. Immunol. 149:3411-3415(1992). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE B*45:04). RA Carey K., Green A., Dunn P.P.; RT "The complete nucleotide sequence of a variant HLA-B*4501 allele."; RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE B*45:01). RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*45:03). RX PubMed=11169261; DOI=10.1034/j.1399-0039.2001.057001070.x; RA Cox S.T., Mcwhinnie A.J., Koester R.P., Heine U., Holman R., RA Madrigal A.J., Little A.-M.; RT "Further diversity at HLA-A and -B loci identified in Afro-Caribbean RT potential bone marrow donors."; RL Tissue Antigens 57:70-72(2001). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-45 are known: B*45:01 (B- CC 12), B*45:03 and B*45:04. The sequence shown is that of B*45:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X61710; CAA43879.1; -; mRNA. DR EMBL; AJ278944; CAC07211.1; -; Genomic_DNA. DR EMBL; AJ458992; CAD30340.1; -; Genomic_DNA. DR EMBL; AJ275937; CAB83041.1; -; Genomic_DNA. DR PIR; I37519; I37519. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; P30483; -. DR SMR; P30483; -. DR IntAct; P30483; 3. DR SwissPalm; P30483; -. DR DMDM; 231406; -. DR PeptideAtlas; P30483; -. DR PRIDE; P30483; -. DR Ensembl; ENST00000450871; ENSP00000388208; ENSG00000232126. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30483; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-45 alpha chain. FT /FTId=PRO_0000018848. FT TOPO_DOM 25 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 9 9 V -> L (in dbSNP:rs1050462). FT /FTId=VAR_056387. FT VARIANT 17 17 L -> V (in dbSNP:rs1131165). FT /FTId=VAR_056388. FT VARIANT 139 139 Q -> R (in allele B*45:03). FT /FTId=VAR_016471. FT VARIANT 191 191 S -> W (in allele B*45:04). FT /FTId=VAR_016472. SQ SEQUENCE 362 AA; 40414 MW; A6C843121D613695 CRC64; MRVTAPRTVL LLLSAALALT ETWAGSHSMR YFHTAMSRPG RGEPRFITVG YVDDTLFVRF DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE SLRNLRGYYN QSEAGSHTWQ RMYGCDLGPD GRLLRGYNQL AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQD RAYLEGLCVE SLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B46_HUMAN Reviewed; 362 AA. AC P30484; Q9TPR2; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 144. DE RecName: Full=HLA class I histocompatibility antigen, B-46 alpha chain; DE AltName: Full=Bw-46; DE AltName: Full=MHC class I antigen B*46; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE B*46:01). RX PubMed=2715640; RA Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.; RT "Diversity and diversification of HLA-A,B,C alleles."; RL J. Immunol. 142:3937-3950(1989). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE B*46:01). RC TISSUE=Blood; RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*46:02). RX PubMed=10885569; DOI=10.1034/j.1399-0039.2000.550511.x; RA Akesaka T., Kashiwase K., Shimamura M., Ishikawa Y., Tanaka H., RA Fujii M., Akaza T., Honda K., Yuasa S., Takahashi T., Juji T.; RT "Identification of a novel HLA-B46 allele, B*4602, in Japanese."; RL Tissue Antigens 55:460-462(2000). RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- INTERACTION: CC P43628:KIR2DL3; NbExp=2; IntAct=EBI-6163582, EBI-8632435; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-46 are known: B*46:01 and CC B*46:02. The sequence shown is that of B*46:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M24033; AAA59665.1; -; mRNA. DR EMBL; AJ310508; CAC34573.1; -; Genomic_DNA. DR EMBL; AB032091; BAA84111.1; -; Genomic_DNA. DR PIR; I61863; I61863. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 4LCY; X-ray; 1.60 A; A/F=25-298. DR PDBsum; 4LCY; -. DR ProteinModelPortal; P30484; -. DR SMR; P30484; -. DR IntAct; P30484; 5. DR SwissPalm; P30484; -. DR DMDM; 231407; -. DR EPD; P30484; -. DR MaxQB; P30484; -. DR PeptideAtlas; P30484; -. DR PRIDE; P30484; -. DR Ensembl; ENST00000450871; ENSP00000388208; ENSG00000232126. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30484; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-46 alpha chain. FT /FTId=PRO_0000018849. FT TOPO_DOM 25 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 98 98 D -> G (in allele B*46:02). FT /FTId=VAR_016473. FT STRAND 27 36 {ECO:0000244|PDB:4LCY}. FT TURN 39 41 {ECO:0000244|PDB:4LCY}. FT STRAND 45 52 {ECO:0000244|PDB:4LCY}. FT STRAND 55 61 {ECO:0000244|PDB:4LCY}. FT STRAND 68 71 {ECO:0000244|PDB:4LCY}. FT HELIX 74 76 {ECO:0000244|PDB:4LCY}. FT HELIX 81 108 {ECO:0000244|PDB:4LCY}. FT STRAND 113 115 {ECO:0000244|PDB:4LCY}. FT STRAND 118 127 {ECO:0000244|PDB:4LCY}. FT STRAND 133 142 {ECO:0000244|PDB:4LCY}. FT STRAND 145 150 {ECO:0000244|PDB:4LCY}. FT STRAND 157 161 {ECO:0000244|PDB:4LCY}. FT HELIX 164 173 {ECO:0000244|PDB:4LCY}. FT HELIX 176 185 {ECO:0000244|PDB:4LCY}. FT HELIX 187 198 {ECO:0000244|PDB:4LCY}. FT HELIX 200 203 {ECO:0000244|PDB:4LCY}. FT STRAND 210 235 {ECO:0000244|PDB:4LCY}. FT STRAND 238 243 {ECO:0000244|PDB:4LCY}. FT HELIX 249 251 {ECO:0000244|PDB:4LCY}. FT STRAND 261 263 {ECO:0000244|PDB:4LCY}. FT STRAND 265 274 {ECO:0000244|PDB:4LCY}. FT HELIX 278 280 {ECO:0000244|PDB:4LCY}. FT STRAND 281 286 {ECO:0000244|PDB:4LCY}. FT STRAND 294 296 {ECO:0000244|PDB:4LCY}. SQ SEQUENCE 362 AA; 40440 MW; 481B4C6876CB0E85 CRC64; MRVTAPRTVL LLLSGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRMA PRAPWIEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHDQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQW RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B47_HUMAN Reviewed; 362 AA. AC P30485; O19555; O77933; Q95392; Q9GIL3; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 138. DE RecName: Full=HLA class I histocompatibility antigen, B-47 alpha chain; DE AltName: Full=Bw-47; DE AltName: Full=MHC class I antigen B*47; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*47:01). RX PubMed=3257938; DOI=10.1007/BF00376123; RA Zemmour J., Ennis P.D., Parham P., Dupont B.; RT "Comparison of the structure of HLA-Bw47 to HLA-B13 and its RT relationship to 21-hydroxylase deficiency."; RL Immunogenetics 27:281-287(1988). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE B*47:01). RC TISSUE=Blood; RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-302 (ALLELE B*47:02). RC TISSUE=Peripheral blood; RX PubMed=9174155; DOI=10.1111/j.1399-0039.1997.tb02797.x; RA Fischer G.F., Broer E., Fae I., Leitner D., Mayr W.R.; RT "Nucleotide sequence analysis of an HLA-B47 variant (HLA-B*4702)."; RL Tissue Antigens 49:540-542(1997). RN [4] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*47:03). RX PubMed=11098929; DOI=10.1034/j.1399-0039.2000.560401.x; RA Ellis J.M., Mack S.J., Leke R.F.G., Quakyi I., Johnson A.H., RA Hurley C.K.; RT "Diversity is demonstrated in class I HLA-A and HLA-B alleles in RT Cameroon, Africa: description of HLA-A*03012, *2612, *3006 and HLA- RT B*1403, *4016, *4703."; RL Tissue Antigens 56:291-302(2000). RN [5] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*47:03). RA Kosman C.A., Hurley C.K.; RT "Novel HLA class I B locus alleles."; RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases. RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-47 are known: B*47:01, CC B*47:02 and B*47:03. The sequence shown is that of B*47:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M19756; AAA52664.1; -; Genomic_DNA. DR EMBL; AJ308398; CAC33087.2; -; Genomic_DNA. DR EMBL; AJ295141; CAC17463.2; -; Genomic_DNA. DR EMBL; Y09118; CAA70335.1; -; mRNA. DR EMBL; AH005564; AAB70513.1; -; Genomic_DNA. DR EMBL; AH006183; AAC23752.1; -; Genomic_DNA. DR PIR; I68724; I68724. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; P30485; -. DR SMR; P30485; -. DR SwissPalm; P30485; -. DR DMDM; 231408; -. DR EPD; P30485; -. DR MaxQB; P30485; -. DR PeptideAtlas; P30485; -. DR PRIDE; P30485; -. DR Ensembl; ENST00000435618; ENSP00000405178; ENSG00000224608. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30485; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-47 alpha chain. FT /FTId=PRO_0000018850. FT TOPO_DOM 25 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 101 101 D -> S (in allele B*47:02 and allele FT B*47:03; requires 2 nucleotide FT substitutions). FT /FTId=VAR_016474. FT VARIANT 104 104 T -> N (in allele B*47:02 and allele FT B*47:03). FT /FTId=VAR_016475. FT VARIANT 106 107 LR -> RG (in allele B*47:02). FT /FTId=VAR_016476. FT VARIANT 306 306 V -> I (in dbSNP:rs1131500). FT /FTId=VAR_056389. FT VARIANT 329 329 A -> T (in dbSNP:rs1051488). FT /FTId=VAR_056390. FT VARIANT 349 349 C -> S (in dbSNP:rs2308655). FT /FTId=VAR_061424. FT VARIANT 349 349 C -> Y (in dbSNP:rs2308655). FT /FTId=VAR_061425. SQ SEQUENCE 362 AA; 40571 MW; E3D3E4CBF8C15EAE CRC64; MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFITVG YVDDTLFVRF DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE DLRTLLRYYN QSEAGSHTLQ RMFGCDVGPD GRLLRGYHQD AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGECVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV VCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA // ID 1B48_HUMAN Reviewed; 362 AA. AC P30486; Q29764; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 144. DE RecName: Full=HLA class I histocompatibility antigen, B-48 alpha chain; DE AltName: Full=Bw-48; DE AltName: Full=MHC class I antigen B*48; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE B*48:01). RX PubMed=1317015; DOI=10.1038/357326a0; RA Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J., RA Williams R.C., Luz R., Petzl-Erler M.L., Parham P.; RT "Unusual HLA-B alleles in two tribes of Brazilian Indians."; RL Nature 357:326-329(1992). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE B*48:01). RC TISSUE=Blood; RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] OF 26-206 (ALLELE B*48:03). RX PubMed=10372543; DOI=10.1034/j.1399-0039.1999.530504.x; RA Marcos C.Y., Fernandez-Vina M.A., Lazaro A.M., Moraes M.E., RA Moraes J.R., Stastny P.; RT "Novel HLA-A and HLA-B alleles in South American Indians."; RL Tissue Antigens 53:476-485(1999). RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [6] RP VARIANT [LARGE SCALE ANALYSIS] THR-65, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-48 are known: B*48:01 and CC B*48:03. The sequence shown is that of B*48:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M84380; AAA59629.1; -; mRNA. DR EMBL; AJ309139; CAC38066.1; -; Genomic_DNA. DR EMBL; L76931; AAB59617.1; -; mRNA. DR PIR; I61903; I61903. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; P30486; -. DR SMR; P30486; -. DR SwissPalm; P30486; -. DR EPD; P30486; -. DR MaxQB; P30486; -. DR PeptideAtlas; P30486; -. DR PRIDE; P30486; -. DR Ensembl; ENST00000412585; ENSP00000399168; ENSG00000234745. DR DisGeNET; 3106; -. DR EuPathDB; HostDB:ENSG00000234745.9; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR HPA; CAB015418; -. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30486; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000234745; Expressed in 92 organ(s), highest expression level in blood. DR CleanEx; HS_HLA-B; -. DR ExpressionAtlas; P30486; baseline and differential. DR Genevisible; P30486; HS. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-48 alpha chain. FT /FTId=PRO_0000018851. FT TOPO_DOM 25 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 4 4 M -> T (in dbSNP:rs1050458). FT /FTId=VAR_056391. FT VARIANT 9 9 V -> L (in dbSNP:rs1050462). FT /FTId=VAR_056392. FT VARIANT 17 17 L -> V (in dbSNP:rs1131165). FT /FTId=VAR_056393. FT VARIANT 35 35 S -> A (in dbSNP:rs1131170). FT /FTId=VAR_056394. FT VARIANT 36 36 V -> M (in dbSNP:rs1050486). FT /FTId=VAR_056395. FT VARIANT 48 48 S -> A (in dbSNP:rs713031). FT /FTId=VAR_061426. FT VARIANT 48 48 S -> P (in dbSNP:rs713031). FT /FTId=VAR_061427. FT VARIANT 48 48 S -> T (in dbSNP:rs713031). FT /FTId=VAR_061428. FT VARIANT 65 65 A -> T (in dbSNP:rs1050529). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056396. FT VARIANT 101 101 S -> N (in dbSNP:rs1050388). FT /FTId=VAR_056397. FT VARIANT 121 121 S -> R (in allele B*48:03). FT /FTId=VAR_016477. FT VARIANT 137 137 H -> Y (in dbSNP:rs1050379). FT /FTId=VAR_056398. FT VARIANT 155 155 R -> S (in dbSNP:rs1050654). FT /FTId=VAR_056399. FT VARIANT 187 187 E -> A (in dbSNP:rs2308466). FT /FTId=VAR_059482. FT VARIANT 187 187 E -> G (in dbSNP:rs2308466). FT /FTId=VAR_059483. FT VARIANT 187 187 E -> K (in dbSNP:rs2523600). FT /FTId=VAR_059484. FT VARIANT 187 187 E -> Q (in dbSNP:rs2523600). FT /FTId=VAR_059485. FT VARIANT 187 187 E -> V (in dbSNP:rs2308466). FT /FTId=VAR_059486. FT VARIANT 195 195 Y -> H (in dbSNP:rs1050696). FT /FTId=VAR_056400. FT VARIANT 306 306 V -> I (in dbSNP:rs1131500). FT /FTId=VAR_056401. FT VARIANT 329 329 A -> T (in dbSNP:rs1051488). FT /FTId=VAR_056402. FT VARIANT 349 349 C -> S (in dbSNP:rs2308655). FT /FTId=VAR_061429. FT VARIANT 349 349 C -> Y (in dbSNP:rs2308655). FT /FTId=VAR_061430. SQ SEQUENCE 362 AA; 40362 MW; 8FADC7B64EBD5C8D CRC64; MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQISQRK LEAARVAEQL RAYLEGECVE WLRRYLENGK DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWTA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA // ID 1B49_HUMAN Reviewed; 362 AA. AC P30487; O19625; Q9MY37; Q9MY93; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 2. DT 12-SEP-2018, entry version 141. DE RecName: Full=HLA class I histocompatibility antigen, B-49 alpha chain; DE AltName: Full=HLA class I histocompatibility antigen, B-21 alpha chain; DE AltName: Full=MHC class I antigen B*49; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE B*49:01). RX PubMed=2715640; RA Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.; RT "Diversity and diversification of HLA-A,B,C alleles."; RL J. Immunol. 142:3937-3950(1989). RN [2] RP SEQUENCE REVISION TO 78. RX PubMed=1385528; RA Hildebrand W.H., Madrigal J.A., Belich M.P., Zemmour J., Ward F.E., RA Williams R.C., Parham P.; RT "Serologic cross-reactivities poorly reflect allelic relationships in RT the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 RT helix."; RL J. Immunol. 149:3563-3568(1992). RN [3] RP NUCLEOTIDE SEQUENCE OF 1-322 (ALLELE B*49:01). RA Hurley C.K., Bei M., Rodriguez S., Johnson A.; RL Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*49:02). RA Gans C.P., Hurley C.K.; RT "Novel HLA-B Allele."; RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*49:03). RX PubMed=11556975; DOI=10.1034/j.1399-0039.2001.057005478.x; RA Darke C., Street J., Guttridge M.G.; RT "Sequence, genetics and serology of a new HLA-B allele: B*4903."; RL Tissue Antigens 57:478-480(2001). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-49 are known: B*49:01, CC B*49:02 and B*49:03 (B*RA). The sequence shown is that of B*49:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M24037; AAA02950.1; -; mRNA. DR EMBL; U11263; AAA19923.1; -; mRNA. DR EMBL; AH009483; AAF78054.1; -; Genomic_DNA. DR EMBL; AJ288980; CAB88084.1; -; Genomic_DNA. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; P30487; -. DR SMR; P30487; -. DR SwissPalm; P30487; -. DR DMDM; 1345599; -. DR MaxQB; P30487; -. DR PeptideAtlas; P30487; -. DR PRIDE; P30487; -. DR Ensembl; ENST00000435618; ENSP00000405178; ENSG00000224608. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR H-InvDB; HIX0166654; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30487; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-49 alpha chain. FT /FTId=PRO_0000018852. FT TOPO_DOM 25 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 9 9 V -> L (in dbSNP:rs1050462). FT /FTId=VAR_056403. FT VARIANT 17 17 L -> V (in dbSNP:rs1131165). FT /FTId=VAR_056404. FT VARIANT 48 48 T -> A (in allele B*49:03). FT /FTId=VAR_016512. FT VARIANT 56 56 L -> Q (in allele B*49:03). FT /FTId=VAR_016513. FT VARIANT 65 65 T -> A (in allele B*49:03). FT /FTId=VAR_016514. FT VARIANT 69 69 K -> T (in allele B*49:03). FT /FTId=VAR_016515. FT VARIANT 104 104 I -> T (in allele B*49:02). FT /FTId=VAR_016516. SQ SEQUENCE 362 AA; 40581 MW; 77B1C82AD3DAEB4A CRC64; MRVTAPRTVL LLLSAALALT ETWAGSHSMR YFHTAMSRPG RGEPRFITVG YVDDTLFVRF DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE NLRIALRYYN QSEAGSHTWQ RMYGCDLGPD GRLLRGYNQL AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQL RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B50_HUMAN Reviewed; 362 AA. AC P30488; O19615; O19624; O19641; O19783; O46702; O78172; Q9TQG1; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 138. DE RecName: Full=HLA class I histocompatibility antigen, B-50 alpha chain; DE AltName: Full=Bw-50; DE AltName: Full=HLA class I histocompatibility antigen, B-21 alpha chain; DE AltName: Full=MHC class I antigen B*50; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE B*50:01). RX PubMed=1431115; RA Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J., RA Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., RA Martell R.W., du Toit E.D., Parham P.; RT "Distinctive HLA-A,B antigens of black populations formed by RT interallelic conversion."; RL J. Immunol. 149:3411-3415(1992). RN [2] RP NUCLEOTIDE SEQUENCE OF 1-322 (ALLELE B*50:01). RA Hurley C.K., Bei M., Rodriguez S., Johnson A.; RT "HLA-B71."; RL Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*50:01). RA Ando H., Mizuki N., Ohno S., Inoko H.; RT "Identification of new HLA-B alleles among Greek population."; RL Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*50:02). RX PubMed=9243753; DOI=10.1111/j.1399-0039.1997.tb02831.x; RA Vilches C., Bunce M., de Pablo R., Murray A.K., McIntyre C.A., RA Kreisler M.; RT "Complete coding regions of two novel HLA-B alleles detected by RT phototyping (PCR-SSP) in the British Caucasoid population: B*5108 and RT B*5002."; RL Tissue Antigens 50:38-41(1997). RN [5] RP NUCLEOTIDE SEQUENCE (ALLELE B*50:02). RA Balas A., Santos S., Vicario J.L.; RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*50:02). RC TISSUE=Blood; RX PubMed=9694362; DOI=10.1111/j.1399-0039.1998.tb03012.x; RA Darke C., Guttridge M.G., Thompson J., Street J., Thomas M.; RT "Molecular, serological and population studies on a novel HLA-B allele RT -- HLA-B*5002."; RL Tissue Antigens 51:666-670(1998). RN [7] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*50:02). RC TISSUE=Blood; RA Gao X., Matheson B.; RT "A novel hla-b50 variant found in an Australian Caucasoid donor."; RL Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*50:02). RA Steiner N.K., Hurley C.K.; RT "Novel HLA-B alleles."; RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*50:04). RX PubMed=11556976; DOI=10.1034/j.1399-0039.2001.057005481.x; RA Steiner N.K., Kosman C., Jones P.F., Gans C.P., Rodriguez-Marino S.G., RA Rizzuto G., Baldassarre L.A., Edson S., Koester R., Sese D., RA Mitton W., Ng J., Hartzman R.J., Hurley C.K.; RT "Twenty-nine new HLA-B alleles associated with antigens in the 5C RT CREG."; RL Tissue Antigens 57:481-485(2001). RN [10] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [11] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [12] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-50 are known: B*50:01, CC B*50:02 (B*45ZJ; B50IM) and B*50:04. The sequence shown is that of CC B*50:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X61706; CAA43875.1; -; mRNA. DR EMBL; U11261; AAA19921.1; -; mRNA. DR EMBL; D50693; BAA23588.1; -; Genomic_DNA. DR EMBL; Y08995; CAA70199.1; -; mRNA. DR EMBL; AF006634; AAD01274.1; -; mRNA. DR EMBL; Y14205; CAA74596.1; -; Genomic_DNA. DR EMBL; AH005672; AAB87724.1; -; Genomic_DNA. DR EMBL; AH005462; AAB63511.1; -; Genomic_DNA. DR EMBL; AH007772; AAD34474.1; -; Genomic_DNA. DR PIR; I37520; I37520. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; P30488; -. DR SMR; P30488; -. DR SwissPalm; P30488; -. DR DMDM; 231411; -. DR PeptideAtlas; P30488; -. DR PRIDE; P30488; -. DR Ensembl; ENST00000450871; ENSP00000388208; ENSG00000232126. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30488; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-50 alpha chain. FT /FTId=PRO_0000018853. FT TOPO_DOM 25 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 9 9 V -> L (in dbSNP:rs1050462). FT /FTId=VAR_056405. FT VARIANT 17 17 L -> V (in dbSNP:rs1131165). FT /FTId=VAR_056406. FT VARIANT 127 127 L -> V (in allele B*50:04). FT /FTId=VAR_016517. FT VARIANT 191 191 W -> S (in allele B*50:02). FT /FTId=VAR_016518. SQ SEQUENCE 362 AA; 40541 MW; 729B0736F81C4AB4 CRC64; MRVTAPRTVL LLLSAALALT ETWAGSHSMR YFHTAMSRPG RGEPRFITVG YVDDTLFVRF DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE SLRNLRGYYN QSEAGSHTWQ RMYGCDLGPD GRLLRGYNQL AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQL RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B51_HUMAN Reviewed; 362 AA. AC P18464; O19675; O78173; P30489; Q29851; Q29857; Q96IT9; Q9MY43; DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1990, sequence version 1. DT 12-SEP-2018, entry version 162. DE RecName: Full=HLA class I histocompatibility antigen, B-51 alpha chain; DE AltName: Full=MHC class I antigen B*51; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*51:01). RX PubMed=2320591; DOI=10.1073/pnas.87.7.2833; RA Ennis P.D., Zemmour J., Salter R.D., Parham P.; RT "Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: RT frequency and nature of errors produced in amplification."; RL Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*51:01). RX PubMed=2909619; RA Hayashi H., Ennis P.D., Ariga H., Salter R.D., Parham P., Kano K., RA Takiguchi M.; RT "HLA-B51 and HLA-Bw52 differ by only two amino acids which are in the RT helical region of the alpha 1 domain."; RL J. Immunol. 142:306-311(1989). RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE B*51:01). RX PubMed=2714852; DOI=10.1007/BF00352839; RA Pohla H., Kuon W., Tabaczewski P., Doerner C., Weiss E.H.; RT "Allelic variation in HLA-B and HLA-C sequences and the evolution of RT the HLA-B alleles."; RL Immunogenetics 29:297-307(1989). RN [4] RP NUCLEOTIDE SEQUENCE (ALLELE B*51:04). RX PubMed=1317015; DOI=10.1038/357326a0; RA Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J., RA Williams R.C., Luz R., Petzl-Erler M.L., Parham P.; RT "Unusual HLA-B alleles in two tribes of Brazilian Indians."; RL Nature 357:326-329(1992). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*51:03). RC TISSUE=Peripheral blood; RX PubMed=8248893; DOI=10.1111/j.1399-0039.1993.tb02164.x; RA Kawaguchi G., Nakayama S., Nagao T., Takiguchi M.; RT "A single amino acid substitution at residue 167 forms a novel HLA-B51 RT subtype."; RL Tissue Antigens 42:39-41(1993). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*51:02). RX PubMed=8929712; DOI=10.1111/j.1399-0039.1996.tb02513.x; RA Prilliman K., Steiner N.K., Ellexson M., Stewart D., Lau M., RA Terasaki P., Hurley C.K., Hildebrand W.H.; RT "Novel alleles HLA-B*7802 and B*51022: evidence for convergency in the RT HLA-B5 family."; RL Tissue Antigens 47:49-57(1996). RN [7] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*51:08). RX PubMed=9243753; DOI=10.1111/j.1399-0039.1997.tb02831.x; RA Vilches C., Bunce M., de Pablo R., Murray A.K., McIntyre C.A., RA Kreisler M.; RT "Complete coding regions of two novel HLA-B alleles detected by RT phototyping (PCR-SSP) in the British Caucasoid population: B*5108 and RT B*5002."; RL Tissue Antigens 50:38-41(1997). RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*51:01). RX PubMed=11696219; DOI=10.1034/j.1399-0039.2001.580202.x; RA Sano K., Yabuki K., Imagawa Y., Shiina T., Mizuki N., Ohno S., RA Kulski J.K., Inoko H.; RT "The absence of disease-specific polymorphisms within the HLA-B51 gene RT that is the susceptible locus for Behcet's disease."; RL Tissue Antigens 58:77-82(2001). RN [9] RP NUCLEOTIDE SEQUENCE (ALLELE B*51:01). RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [10] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-206 (ALLELE B*51:01). RX PubMed=7871529; DOI=10.1111/j.1399-0039.1994.tb02394.x; RA Steinle A., Schendel D.J.; RT "HLA class I alleles of LCL 721 and 174 x CEM.T2 (T2)."; RL Tissue Antigens 44:268-270(1994). RN [11] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-362 (ALLELE B*51:01). RC TISSUE=Lymph; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [12] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*51:24). RC TISSUE=Peripheral blood; RX PubMed=11580855; DOI=10.1034/j.1399-0039.2001.580107.x; RA Anholts J.D.H., Kemps-Mols B., Verduijn W., Oudshoorn M., RA Schreuder G.M.T.; RT "Three newly identified HLA-B alleles: B*5124, B*5306, B*5307 and RT confirmation of B*0809 and B*5606."; RL Tissue Antigens 58:38-41(2001). RN [13] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [14] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [15] RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 25-300 (B*51:01). RX PubMed=10975842; DOI=10.4049/jimmunol.165.6.3260; RA Maenaka K., Maenaka T., Tomiyama H., Takiguchi M., Stuart D.I., RA Jones E.Y.; RT "Nonstandard peptide binding revealed by crystal structures of HLA- RT B*5101 complexed with HIV immunodominant epitopes."; RL J. Immunol. 165:3260-3267(2000). RN [16] RP INVOLVEMENT IN BEHCET DISEASE. RX PubMed=15063364; DOI=10.1016/j.coph.2003.10.009; RA Arayssi T., Hamdan A.; RT "New insights into the pathogenesis and therapy of Behcet's disease."; RL Curr. Opin. Pharmacol. 4:183-188(2004). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-51 are known: B*51:01, CC B*51:03, B*51:04, B*51:08 and B*51:24. The sequence shown is that CC of B*51:01. CC -!- MISCELLANEOUS: There is evidence that HLA-B51 is associated with CC susceptibility to Behcet disease. However, it is not certain CC whether HLA-B51 itself or a closely linked gene is responsible for CC susceptibility. The world distribution of HLA-B51 in healthy CC people corresponds to the global distribution of Behcet disease; CC in Southern hemisphere countries (Africa, South Pacific, etc.) and CC in some parts of Europe, the prevalence of HLA-B51 in healthy CC people is low or null, corresponding to a low prevalence of Behcet CC disease. The wide variation that exists in the relative risk of CC HLA-B51 would support other nongenetic risk factors. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M32319; AAA36232.1; -; mRNA. DR EMBL; M22792; AAA59620.1; ALT_SEQ; Genomic_DNA. DR EMBL; M22786; AAA59620.1; JOINED; Genomic_DNA. DR EMBL; M22787; AAA59620.1; JOINED; Genomic_DNA. DR EMBL; M22788; AAA59620.1; JOINED; Genomic_DNA. DR EMBL; M22789; AAA59620.1; JOINED; Genomic_DNA. DR EMBL; M22790; AAA59620.1; JOINED; Genomic_DNA. DR EMBL; M22791; AAA59620.1; JOINED; Genomic_DNA. DR EMBL; L41087; AAA64513.1; -; Genomic_DNA. DR EMBL; L41086; AAA64513.1; JOINED; Genomic_DNA. DR EMBL; Z15143; CAA78849.1; -; mRNA. DR EMBL; M80670; AAA52661.1; -; Genomic_DNA. DR EMBL; L41925; AAC41979.1; -; mRNA. DR EMBL; Y08994; CAA70198.1; -; mRNA. DR EMBL; AB056860; BAB64902.1; -; Genomic_DNA. DR EMBL; AB056862; BAB64904.1; -; Genomic_DNA. DR EMBL; AB056863; BAB64905.1; -; Genomic_DNA. DR EMBL; AB056864; BAB64906.1; -; Genomic_DNA. DR EMBL; AB056865; BAB64907.1; -; Genomic_DNA. DR EMBL; AJ278903; CAC05371.1; -; Genomic_DNA. DR EMBL; BC007243; AAH07243.1; -; mRNA. DR EMBL; AJ276995; CAB86196.1; -; Genomic_DNA. DR EMBL; Z46808; CAA86838.1; -; mRNA. DR PIR; A30345; A30345. DR PIR; I37120; I37120. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 1E27; X-ray; 2.20 A; A=25-300. DR PDB; 1E28; X-ray; 3.00 A; A=25-300. DR PDB; 4MJI; X-ray; 2.99 A; A/F=25-300. DR PDBsum; 1E27; -. DR PDBsum; 1E28; -. DR PDBsum; 4MJI; -. DR ProteinModelPortal; P18464; -. DR SMR; P18464; -. DR DIP; DIP-6150N; -. DR MINT; P18464; -. DR SwissPalm; P18464; -. DR DMDM; 122172; -. DR MaxQB; P18464; -. DR PeptideAtlas; P18464; -. DR PRIDE; P18464; -. DR Ensembl; ENST00000359635; ENSP00000352656; ENSG00000206450. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR H-InvDB; HIX0005715; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P18464; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR EvolutionaryTrace; P18464; -. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; IDA:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; IDA:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; IDA:UniProtKB. DR GO; GO:0002486; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-51 alpha chain. FT /FTId=PRO_0000018854. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 118 121 TWQT -> IIQR (in allele B*51:04). FT /FTId=VAR_016478. FT VARIANT 155 155 S -> R (in allele B*51:24). FT /FTId=VAR_017442. FT VARIANT 176 176 E -> V (in allele B*51:08). FT /FTId=VAR_016479. FT VARIANT 180 180 L -> D (in allele B*51:08; requires 2 FT nucleotide substitutions). FT /FTId=VAR_016480. FT VARIANT 191 191 W -> G (in allele B*51:03). FT /FTId=VAR_016481. FT VARIANT 195 195 H -> Y (in allele B*51:02). FT /FTId=VAR_016482. FT STRAND 27 36 {ECO:0000244|PDB:1E27}. FT TURN 39 41 {ECO:0000244|PDB:4MJI}. FT STRAND 45 52 {ECO:0000244|PDB:1E27}. FT STRAND 55 61 {ECO:0000244|PDB:1E27}. FT STRAND 64 66 {ECO:0000244|PDB:1E27}. FT HELIX 74 78 {ECO:0000244|PDB:1E27}. FT HELIX 81 108 {ECO:0000244|PDB:1E27}. FT STRAND 118 127 {ECO:0000244|PDB:1E27}. FT STRAND 133 142 {ECO:0000244|PDB:1E27}. FT STRAND 145 150 {ECO:0000244|PDB:1E27}. FT STRAND 157 161 {ECO:0000244|PDB:1E27}. FT HELIX 162 173 {ECO:0000244|PDB:1E27}. FT HELIX 176 185 {ECO:0000244|PDB:1E27}. FT HELIX 187 198 {ECO:0000244|PDB:1E27}. FT HELIX 200 203 {ECO:0000244|PDB:1E27}. FT STRAND 210 217 {ECO:0000244|PDB:1E27}. FT STRAND 219 235 {ECO:0000244|PDB:1E27}. FT STRAND 238 243 {ECO:0000244|PDB:1E27}. FT HELIX 249 251 {ECO:0000244|PDB:1E27}. FT STRAND 252 254 {ECO:0000244|PDB:1E27}. FT STRAND 261 263 {ECO:0000244|PDB:1E27}. FT STRAND 265 274 {ECO:0000244|PDB:1E27}. FT HELIX 278 280 {ECO:0000244|PDB:1E27}. FT STRAND 281 286 {ECO:0000244|PDB:1E27}. FT STRAND 290 292 {ECO:0000244|PDB:1E27}. FT STRAND 294 296 {ECO:0000244|PDB:1E27}. SQ SEQUENCE 362 AA; 40566 MW; D104163B4CC71F92 CRC64; MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRTE PRAPWIEQEG PEYWDRNTQI FKTNTQTYRE NLRIALRYYN QSEAGSHTWQ TMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQL RAYLEGLCVE WLRRHLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B52_HUMAN Reviewed; 362 AA. AC P30490; Q9MY75; Q9TPT4; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 141. DE RecName: Full=HLA class I histocompatibility antigen, B-52 alpha chain; DE AltName: Full=Bw-52; DE AltName: Full=HLA class I histocompatibility antigen, B-5 alpha chain; DE AltName: Full=MHC class I antigen B*52; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*52:01). RX PubMed=2909619; RA Hayashi H., Ennis P.D., Ariga H., Salter R.D., Parham P., Kano K., RA Takiguchi M.; RT "HLA-B51 and HLA-Bw52 differ by only two amino acids which are in the RT helical region of the alpha 1 domain."; RL J. Immunol. 142:306-311(1989). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*52:02). RA Jones P.F., Hurley C.K.; RT "Novel HLA-B allele."; RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*52:03). RA Gans C.P., Hurley C.K.; RT "Novel HLA-B allele."; RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases. RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-52 are known: B*52:01, CC B*52:02 (B*52012V) and B*52:03. The sequence shown is that of CC B*52:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M22799; AAA59645.1; ALT_SEQ; Genomic_DNA. DR EMBL; M22793; AAA59645.1; JOINED; Genomic_DNA. DR EMBL; M22794; AAA59645.1; JOINED; Genomic_DNA. DR EMBL; M22795; AAA59645.1; JOINED; Genomic_DNA. DR EMBL; M22796; AAA59645.1; JOINED; Genomic_DNA. DR EMBL; M22797; AAA59645.1; JOINED; Genomic_DNA. DR EMBL; M22798; AAA59645.1; JOINED; Genomic_DNA. DR EMBL; AH008246; AAF00933.1; -; Genomic_DNA. DR EMBL; AH009592; AAF81610.1; -; Genomic_DNA. DR PIR; B30345; B30345. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 3W39; X-ray; 3.10 A; A/D=25-300. DR PDBsum; 3W39; -. DR ProteinModelPortal; P30490; -. DR SMR; P30490; -. DR SwissPalm; P30490; -. DR EPD; P30490; -. DR MaxQB; P30490; -. DR PeptideAtlas; P30490; -. DR PRIDE; P30490; -. DR Ensembl; ENST00000450871; ENSP00000388208; ENSG00000232126. DR UCSC; uc011hpp.3; human. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30490; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-52 alpha chain. FT /FTId=PRO_0000018855. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 69 70 TE -> MA (in allele B*52:02). FT /FTId=VAR_016521. FT VARIANT 176 176 E -> V (in allele B*52:03). FT /FTId=VAR_016522. FT VARIANT 195 195 H -> Y (in allele B*52:03). FT /FTId=VAR_016523. FT STRAND 27 36 {ECO:0000244|PDB:3W39}. FT STRAND 39 41 {ECO:0000244|PDB:3W39}. FT STRAND 45 52 {ECO:0000244|PDB:3W39}. FT STRAND 55 61 {ECO:0000244|PDB:3W39}. FT STRAND 64 66 {ECO:0000244|PDB:3W39}. FT TURN 75 78 {ECO:0000244|PDB:3W39}. FT HELIX 81 109 {ECO:0000244|PDB:3W39}. FT STRAND 118 127 {ECO:0000244|PDB:3W39}. FT STRAND 133 142 {ECO:0000244|PDB:3W39}. FT STRAND 145 150 {ECO:0000244|PDB:3W39}. FT HELIX 162 172 {ECO:0000244|PDB:3W39}. FT TURN 173 175 {ECO:0000244|PDB:3W39}. FT HELIX 176 185 {ECO:0000244|PDB:3W39}. FT HELIX 187 198 {ECO:0000244|PDB:3W39}. FT HELIX 200 203 {ECO:0000244|PDB:3W39}. FT STRAND 212 217 {ECO:0000244|PDB:3W39}. FT STRAND 219 221 {ECO:0000244|PDB:3W39}. FT STRAND 223 235 {ECO:0000244|PDB:3W39}. FT STRAND 238 247 {ECO:0000244|PDB:3W39}. FT HELIX 249 251 {ECO:0000244|PDB:3W39}. FT STRAND 252 254 {ECO:0000244|PDB:3W39}. FT STRAND 261 263 {ECO:0000244|PDB:3W39}. FT STRAND 265 273 {ECO:0000244|PDB:3W39}. FT HELIX 277 280 {ECO:0000244|PDB:3W39}. FT STRAND 281 286 {ECO:0000244|PDB:3W39}. SQ SEQUENCE 362 AA; 40521 MW; A32E36370FD84F91 CRC64; MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRTE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE NLRIALRYYN QSEAGSHTWQ TMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQL RAYLEGLCVE WLRRHLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B53_HUMAN Reviewed; 362 AA. AC P30491; O78053; O78138; Q30198; Q5TK76; Q9BD43; Q9GJF0; Q9MY42; AC Q9TP36; Q9TQH8; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 156. DE RecName: Full=HLA class I histocompatibility antigen, B-53 alpha chain; DE AltName: Full=Bw-53; DE AltName: Full=MHC class I antigen B*53; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*53:01). RX PubMed=1699887; DOI=10.1007/BF02114973; RA Hayashi H., Ooba T., Nakayama S., Sekimata M., Kano K., Takiguchi M.; RT "Allospecificities between HLA-Bw53 and HLA-B35 are generated by RT substitution of the residues associated with HLA-Bw4/Bw6 public RT epitopes."; RL Immunogenetics 32:195-199(1990). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-206 (ALLELE B*53:01). RC TISSUE=Blood; RX PubMed=9321426; DOI=10.1007/s002510050307; RA Gomez-Casado E., Vargas-Alarcon G., Martinez-Laso J., Perez-Blas M., RA Granados J., Layrisse Z., Montoya F., Varela P., Arnaiz-Villena A.; RT "Generation of the HLA-B35, -B5, -B16, and B15 groups of alleles RT studied by intron 1 and 2 sequence analysis."; RL Immunogenetics 46:469-476(1997). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Blood; RA Cox S.T.; RT "Confirmation of HLA-B*5301."; RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*53:02). RA Hurley C.K., Hoyer R.J.; RT "Human MHC class I antigen HLA-B*5302."; RL Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES B*53:03 AND RP B*53:05). RX PubMed=11556976; DOI=10.1034/j.1399-0039.2001.057005481.x; RA Steiner N.K., Kosman C., Jones P.F., Gans C.P., Rodriguez-Marino S.G., RA Rizzuto G., Baldassarre L.A., Edson S., Koester R., Sese D., RA Mitton W., Ng J., Hartzman R.J., Hurley C.K.; RT "Twenty-nine new HLA-B alleles associated with antigens in the 5C RT CREG."; RL Tissue Antigens 57:481-485(2001). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*53:04). RX PubMed=10777103; DOI=10.1034/j.1399-0039.2000.550311.x; RA Kennedy C.T., Dodd R., Le T., Wallace R., Ng G., Greville W.D., RA Kennedy A., Taverniti A., Moses J.H., Clow N., Watson N., Dunckley H.; RT "Routine HLA-B genotyping with PCR-sequence-specific oligonucleotides RT (PCR-SSO) detects eight new alleles: B*0807, B*0809, B*1551, B*3529, RT B*3532, B*4025, B*5304 and B*5508."; RL Tissue Antigens 55:266-270(2000). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*53:05). RA Tait B., Holdsworth R., Cantwell L., Boyle A., Diviney M.; RT "Confirmatory B*5305 sequence."; RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES B*53:06 AND RP B*53:07). RC TISSUE=Peripheral blood; RX PubMed=11580855; DOI=10.1034/j.1399-0039.2001.580107.x; RA Anholts J.D.H., Kemps-Mols B., Verduijn W., Oudshoorn M., RA Schreuder G.M.T.; RT "Three newly identified HLA-B alleles: B*5124, B*5306, B*5307 and RT confirmation of B*0809 and B*5606."; RL Tissue Antigens 58:38-41(2001). RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [10] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [11] RP X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 25-302. RX PubMed=8624812; DOI=10.1016/S1074-7613(00)80430-6; RA Smith K.J., Reid S.W., Harlos K., McMichael A.J., Stuart D.I., RA Bell J.I., Jones E.Y.; RT "Bound water structure and polymorphic amino acids act together to RT allow the binding of different peptides to MHC class I HLA-B53."; RL Immunity 4:215-228(1996). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-53 are known: B*53:01, CC B*53:02, B*53:03, B*53:04, B*53:05, B*53:06 and B*53:07. The CC sequence shown is that of B*53:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M58636; AAA36228.1; -; Genomic_DNA. DR EMBL; U90566; AAB96793.1; -; Genomic_DNA. DR EMBL; AJ311599; CAC35317.1; -; Genomic_DNA. DR EMBL; AH003636; AAB05926.1; -; Genomic_DNA. DR EMBL; AH006439; AAC35939.1; -; Genomic_DNA. DR EMBL; AH008879; AAF20814.1; -; Genomic_DNA. DR EMBL; AH007566; AAD23461.1; -; Genomic_DNA. DR EMBL; AH010237; AAG53942.1; -; Genomic_DNA. DR EMBL; AJ276996; CAB86197.1; -; Genomic_DNA. DR EMBL; AJ293856; CAC05305.1; -; Genomic_DNA. DR EMBL; AJ293857; CAC05305.1; JOINED; Genomic_DNA. DR PIR; A45834; A45834. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 1A1M; X-ray; 2.30 A; A=25-300. DR PDB; 1A1O; X-ray; 2.30 A; A=25-300. DR PDBsum; 1A1M; -. DR PDBsum; 1A1O; -. DR ProteinModelPortal; P30491; -. DR SMR; P30491; -. DR DIP; DIP-6054N; -. DR IntAct; P30491; 1. DR MINT; P30491; -. DR SwissPalm; P30491; -. DR DMDM; 231414; -. DR EPD; P30491; -. DR MaxQB; P30491; -. DR PeptideAtlas; P30491; -. DR PRIDE; P30491; -. DR Ensembl; ENST00000359635; ENSP00000352656; ENSG00000206450. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30491; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR EvolutionaryTrace; P30491; -. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-53 alpha chain. FT /FTId=PRO_0000018856. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 FT DISULFID 227 283 FT VARIANT 101 101 N -> D (in allele B*53:03). FT /FTId=VAR_016524. FT VARIANT 101 101 N -> S (in allele B*53:05). FT /FTId=VAR_016525. FT VARIANT 104 105 IA -> TL (in allele B*53:03). FT /FTId=VAR_016526. FT VARIANT 118 118 I -> T (in allele B*53:07). FT /FTId=VAR_016527. FT VARIANT 123 123 Y -> S (in allele B*53:07). FT /FTId=VAR_016528. FT VARIANT 127 127 L -> V (in allele B*53:07). FT /FTId=VAR_016529. FT VARIANT 137 138 HD -> YN (in allele B*53:07). FT /FTId=VAR_016530. FT VARIANT 140 140 S -> F (in allele B*53:04 and allele FT B*53:07). FT /FTId=VAR_016531. FT VARIANT 176 176 V -> E (in allele B*53:06). FT /FTId=VAR_016532. FT VARIANT 195 195 Y -> H (in allele B*53:02 and allele FT B*53:06). FT /FTId=VAR_016533. FT STRAND 27 36 {ECO:0000244|PDB:1A1M}. FT STRAND 41 43 {ECO:0000244|PDB:1A1M}. FT STRAND 45 52 {ECO:0000244|PDB:1A1M}. FT STRAND 55 61 {ECO:0000244|PDB:1A1M}. FT STRAND 64 66 {ECO:0000244|PDB:1A1M}. FT HELIX 74 76 {ECO:0000244|PDB:1A1M}. FT HELIX 81 108 {ECO:0000244|PDB:1A1M}. FT STRAND 118 127 {ECO:0000244|PDB:1A1M}. FT STRAND 131 142 {ECO:0000244|PDB:1A1M}. FT STRAND 145 150 {ECO:0000244|PDB:1A1M}. FT STRAND 157 161 {ECO:0000244|PDB:1A1M}. FT HELIX 162 172 {ECO:0000244|PDB:1A1M}. FT TURN 173 175 {ECO:0000244|PDB:1A1M}. FT HELIX 176 185 {ECO:0000244|PDB:1A1M}. FT HELIX 187 198 {ECO:0000244|PDB:1A1M}. FT HELIX 200 203 {ECO:0000244|PDB:1A1M}. FT STRAND 210 217 {ECO:0000244|PDB:1A1M}. FT STRAND 219 235 {ECO:0000244|PDB:1A1M}. FT STRAND 238 243 {ECO:0000244|PDB:1A1M}. FT TURN 249 251 {ECO:0000244|PDB:1A1M}. FT STRAND 261 263 {ECO:0000244|PDB:1A1M}. FT STRAND 265 274 {ECO:0000244|PDB:1A1M}. FT HELIX 278 280 {ECO:0000244|PDB:1A1M}. FT STRAND 281 286 {ECO:0000244|PDB:1A1M}. FT STRAND 290 292 {ECO:0000244|PDB:1A1M}. FT STRAND 294 296 {ECO:0000244|PDB:1A1M}. SQ SEQUENCE 362 AA; 40495 MW; 57BAA748D7854658 CRC64; MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRTE PRAPWIEQEG PEYWDRNTQI FKTNTQTYRE NLRIALRYYN QSEAGSHIIQ RMYGCDLGPD GRLLRGHDQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B54_HUMAN Reviewed; 362 AA. AC P30492; Q9TPQ9; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 139. DE RecName: Full=HLA class I histocompatibility antigen, B-54 alpha chain; DE AltName: Full=Bw-22; DE AltName: Full=Bw-54; DE AltName: Full=MHC class I antigen B*54; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*54:01). RX PubMed=1737933; RA Hildebrand W.H., Madrigal J.A., Little A.-M., Parham P.; RT "HLA-Bw22: a family of molecules with identity to HLA-B7 in the alpha RT 1-helix."; RL J. Immunol. 148:1155-1162(1992). RN [2] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*54:02). RA Juji T., Akesaka T., Kashiwase K., Ishikawa Y.; RT "HLA-B5401V1."; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. RN [3] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-54 are known: B*54:01 and CC B*54:02 (B5401V). The sequence shown is that of B*54:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M77774; AAA03686.1; -; mRNA. DR EMBL; AB032095; BAA84114.1; -; Genomic_DNA. DR PIR; I56130; I56130. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; P30492; -. DR SMR; P30492; -. DR IntAct; P30492; 1. DR SwissPalm; P30492; -. DR DMDM; 231415; -. DR EPD; P30492; -. DR MaxQB; P30492; -. DR PeptideAtlas; P30492; -. DR PRIDE; P30492; -. DR Ensembl; ENST00000359635; ENSP00000352656; ENSG00000206450. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30492; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-54 alpha chain. FT /FTId=PRO_0000018857. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 33 33 Y -> H (in allele B*54:02). FT /FTId=VAR_016534. FT VARIANT 35 36 AM -> SV (in allele B*54:02). FT /FTId=VAR_016535. FT VARIANT 87 87 N -> D (in dbSNP:rs1050570). FT /FTId=VAR_056407. FT VARIANT 87 87 N -> K (in dbSNP:rs1065386). FT /FTId=VAR_059487. FT VARIANT 97 97 T -> A (in dbSNP:rs1050393). FT /FTId=VAR_056408. FT VARIANT 98 98 D -> Y (in dbSNP:rs1131215). FT /FTId=VAR_059488. FT VARIANT 101 101 S -> N (in dbSNP:rs1050388). FT /FTId=VAR_056409. SQ SEQUENCE 362 AA; 40380 MW; 111730024578515D CRC64; MRVTAPRTLL LLLWGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTWQ TMYGCDLGPD GRLLRGHNQL AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B55_HUMAN Reviewed; 362 AA. AC P30493; O78163; P30494; P79489; P79523; Q8MGQ3; Q9GIZ9; Q9GJ00; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 143. DE RecName: Full=HLA class I histocompatibility antigen, B-55 alpha chain; DE AltName: Full=Bw-55; DE AltName: Full=HLA class I histocompatibility antigen, B-12 alpha chain; DE AltName: Full=MHC class I antigen B*55; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; ORFNames=CDABP0067; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*55:01 AND B*55:02). RX PubMed=1737933; RA Hildebrand W.H., Madrigal J.A., Little A.-M., Parham P.; RT "HLA-Bw22: a family of molecules with identity to HLA-B7 in the alpha RT 1-helix."; RL J. Immunol. 148:1155-1162(1992). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE B*55:01). RC TISSUE=Leukemia; RA Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., RA Margolin J.F.; RT "Pediatric leukemia cDNA sequencing project."; RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE (ALLELES B*55:01 AND B*55:12). RC TISSUE=Blood; RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*55:04). RC TISSUE=Blood; RX PubMed=9151389; DOI=10.1111/j.1399-0039.1997.tb02765.x; RA Bannai M., Tokunaga K., Tanaka H., Lin L., Kashiwase K., Tokunaga K., RA Juji T.; RT "Five HLA-B22 group alleles in Japanese."; RL Tissue Antigens 49:376-382(1997). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*55:05). RX PubMed=9174154; DOI=10.1111/j.1399-0039.1997.tb02796.x; RA Szmania S., Seurynck K., Baxter-Lowe L.A.; RT "Nucleotide sequence of HLA-B*5505, which expresses a unique HLA class RT I polymorphism."; RL Tissue Antigens 49:537-539(1997). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*55:08). RX PubMed=10777103; DOI=10.1034/j.1399-0039.2000.550311.x; RA Kennedy C.T., Dodd R., Le T., Wallace R., Ng G., Greville W.D., RA Kennedy A., Taverniti A., Moses J.H., Clow N., Watson N., Dunckley H.; RT "Routine HLA-B genotyping with PCR-sequence-specific oligonucleotides RT (PCR-SSO) detects eight new alleles: B*0807, B*0809, B*1551, B*3529, RT B*3532, B*4025, B*5304 and B*5508."; RL Tissue Antigens 55:266-270(2000). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*55:09). RX PubMed=11580856; DOI=10.1034/j.1399-0039.2001.580108.x; RA Voorter C.E., Hepkema B.G., Mulkers E.M.T., Lems S.P.M., RA van den Berg-Loonen E.M.; RT "Identification of two new HLA-B22 variants, HLA-B*5509 and B*5606."; RL Tissue Antigens 58:42-46(2001). RN [8] RP VARIANT [LARGE SCALE ANALYSIS] THR-65, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [9] RP VARIANT [LARGE SCALE ANALYSIS] TYR-140, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-55 are known: B*55:01, CC B*55:02, B*55:04 (B55.2), B*55:05, B*55:08 (B*ER), B*55:09 and CC B*55:12. The sequence shown is that of B*55:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M77777; AAA03688.1; -; mRNA. DR EMBL; M77778; AAA03687.1; -; mRNA. DR EMBL; AY007140; AAG02001.1; -; mRNA. DR EMBL; AJ310509; CAC34574.1; -; Genomic_DNA. DR EMBL; AJ420106; CAD12250.1; -; Genomic_DNA. DR EMBL; AJ420333; CAD12454.1; -; Genomic_DNA. DR EMBL; D85761; BAA12868.1; -; mRNA. DR EMBL; U63653; AAB40126.1; -; mRNA. DR EMBL; AH006888; AAC61281.1; -; Genomic_DNA. DR EMBL; AJ250628; CAC12872.1; -; Genomic_DNA. DR EMBL; AJ250629; CAC12873.1; -; Genomic_DNA. DR PIR; I72752; I72752. DR PIR; I72753; I72753. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; P30493; -. DR SMR; P30493; -. DR IntAct; P30493; 2. DR SwissPalm; P30493; -. DR DMDM; 231416; -. DR EPD; P30493; -. DR MaxQB; P30493; -. DR PeptideAtlas; P30493; -. DR PRIDE; P30493; -. DR Ensembl; ENST00000359635; ENSP00000352656; ENSG00000206450. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30493; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-55 alpha chain. FT /FTId=PRO_0000018858. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 65 65 A -> T (in dbSNP:rs1050529). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056410. FT VARIANT 82 82 E -> A (in allele B*55:05). FT /FTId=VAR_016483. FT VARIANT 87 87 N -> D (in dbSNP:rs1050570). FT /FTId=VAR_056411. FT VARIANT 87 87 N -> K (in dbSNP:rs1065386). FT /FTId=VAR_059489. FT VARIANT 97 97 T -> A (in dbSNP:rs1050393). FT /FTId=VAR_056412. FT VARIANT 98 98 D -> Y (in dbSNP:rs1131215). FT /FTId=VAR_059490. FT VARIANT 101 101 S -> N (in allele B*55:12; FT dbSNP:rs1050388). FT /FTId=VAR_016484. FT VARIANT 119 119 W -> L (in allele B*55:04 and allele FT B*55:08; requires 2 nucleotide FT substitutions). FT /FTId=VAR_016698. FT VARIANT 121 121 T -> R (in allele B*55:08). FT /FTId=VAR_016699. FT VARIANT 121 121 T -> S (in allele B*55:04). FT /FTId=VAR_016700. FT VARIANT 127 127 L -> V (in allele B*55:04 and allele FT B*55:08). FT /FTId=VAR_016701. FT VARIANT 140 140 L -> Y (in allele B*55:04 and allele FT B*55:08; requires 2 nucleotide FT substitutions). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_016702. FT VARIANT 155 155 S -> R (in allele B*55:04 and allele FT B*55:08). FT /FTId=VAR_016703. FT VARIANT 176 176 E -> V (in allele B*55:02, allele FT B*55:04, allele B*55:08 and allele FT B*55:12). FT /FTId=VAR_016485. FT VARIANT 180 180 L -> R (in allele B*55:09). FT /FTId=VAR_016704. FT VARIANT 187 187 T -> E (in allele B*55:09; requires 2 FT nucleotide substitutions). FT /FTId=VAR_016705. FT VARIANT 187 187 T -> L (in allele B*55:08; requires 2 FT nucleotide substitutions). FT /FTId=VAR_016706. SQ SEQUENCE 362 AA; 40496 MW; 8F3C1F6D245257C4 CRC64; MRVTAPRTLL LLLWGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTWQ TMYGCDLGPD GRLLRGHNQL AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQL RAYLEGTCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B56_HUMAN Reviewed; 362 AA. AC P30495; O19758; P30496; P79490; Q9GIM3; Q9GJ17; Q9TPR4; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 136. DE RecName: Full=HLA class I histocompatibility antigen, B-56 alpha chain; DE AltName: Full=Bw-22; DE AltName: Full=Bw-56; DE AltName: Full=MHC class I antigen B*56; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*56:01 AND B*56:02). RX PubMed=1737933; RA Hildebrand W.H., Madrigal J.A., Little A.-M., Parham P.; RT "HLA-Bw22: a family of molecules with identity to HLA-B7 in the alpha RT 1-helix."; RL J. Immunol. 148:1155-1162(1992). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*56:03). RC TISSUE=Blood; RX PubMed=9151389; DOI=10.1111/j.1399-0039.1997.tb02765.x; RA Bannai M., Tokunaga K., Tanaka H., Lin L., Kashiwase K., Tokunaga K., RA Juji T.; RT "Five HLA-B22 group alleles in Japanese."; RL Tissue Antigens 49:376-382(1997). RN [3] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*56:04). RA Steiner N.K., Lee K.W., Hurley C.K.; RT "Novel HLA-B alleles."; RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*56:05). RA Juji T., Akesaka T., Kashiwase K.; RT "HLA-B56V1(B*5605)."; RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*56:06). RX PubMed=11580856; DOI=10.1034/j.1399-0039.2001.580108.x; RA Voorter C.E., Hepkema B.G., Mulkers E.M.T., Lems S.P.M., RA van den Berg-Loonen E.M.; RT "Identification of two new HLA-B22 variants, HLA-B*5509 and B*5606."; RL Tissue Antigens 58:42-46(2001). RN [6] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*56:07). RX PubMed=11098937; DOI=10.1034/j.1399-0039.2000.560409.x; RA Voorter C.E., van der Vlies S., Kik M., van den Berg-Loonen E.M.; RT "Unexpected Bw4 and Bw6 reactivity patterns in new alleles."; RL Tissue Antigens 56:363-370(2000). RN [7] RP VARIANT [LARGE SCALE ANALYSIS] THR-65, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [8] RP VARIANT [LARGE SCALE ANALYSIS] THR-69, VARIANT [LARGE SCALE ANALYSIS] RP TYR-140, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-56 are known: B*56:01, CC B*56:02, B*56:03 (B22N), B*56:04, B*56:05 (B56V1), B*56:06 and CC B*56:07. The sequence shown is that of B*56:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M77775; AAA03690.1; -; mRNA. DR EMBL; M77776; AAA03689.1; -; mRNA. DR EMBL; D85762; BAA12869.1; -; mRNA. DR EMBL; AH005456; AAB62223.1; -; Genomic_DNA. DR EMBL; AB030574; BAA82677.1; -; Genomic_DNA. DR EMBL; Y18542; CAC12884.1; -; Genomic_DNA. DR EMBL; Y18543; CAC12884.1; JOINED; Genomic_DNA. DR EMBL; Y18544; CAC12896.1; -; Genomic_DNA. DR EMBL; Y18545; CAC12896.1; JOINED; Genomic_DNA. DR PIR; I72754; I72754. DR PIR; I72755; I72755. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; P30495; -. DR SMR; P30495; -. DR IntAct; P30495; 1. DR SwissPalm; P30495; -. DR DMDM; 231418; -. DR MaxQB; P30495; -. DR PeptideAtlas; P30495; -. DR PRIDE; P30495; -. DR Ensembl; ENST00000359635; ENSP00000352656; ENSG00000206450. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30495; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-56 alpha chain. FT /FTId=PRO_0000018859. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 65 65 A -> T (in dbSNP:rs1050529). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056413. FT VARIANT 69 69 E -> T (in allele B*56:06; requires 2 FT nucleotide substitutions). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_016486. FT VARIANT 87 87 N -> D (in dbSNP:rs1050570). FT /FTId=VAR_056414. FT VARIANT 87 87 N -> K (in dbSNP:rs1065386). FT /FTId=VAR_059491. FT VARIANT 97 97 T -> A (in dbSNP:rs1050393). FT /FTId=VAR_056415. FT VARIANT 98 98 D -> Y (in dbSNP:rs1131215). FT /FTId=VAR_059492. FT VARIANT 101 101 S -> N (in allele B*56:07; FT dbSNP:rs1050388). FT /FTId=VAR_016487. FT VARIANT 104 107 NLRG -> TALR (in allele B*56:07). FT /FTId=VAR_016488. FT VARIANT 119 119 W -> L (in allele B*56:02, allele B*56:03 FT and allele B*56:04). FT /FTId=VAR_016489. FT VARIANT 121 121 T -> R (in allele B*56:02, allele B*56:03 FT and allele B*56:04). FT /FTId=VAR_016490. FT VARIANT 127 127 L -> V (in allele B*56:03, allele FT B*56:04, allele B*56:05 and allele FT B*56:06). FT /FTId=VAR_016491. FT VARIANT 138 138 N -> D (in allele B*56:03). FT /FTId=VAR_016707. FT VARIANT 140 140 L -> S (in allele B*56:03). FT /FTId=VAR_016708. FT VARIANT 140 140 L -> Y (in allele B*56:05 and allele FT B*56:06; requires 2 nucleotide FT substitutions). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_016492. FT VARIANT 176 176 V -> E (in allele B*56:03, allele B*56:05 FT and allele B*56:06). FT /FTId=VAR_016493. FT VARIANT 180 180 L -> W (in allele B*56:03). FT /FTId=VAR_016709. FT VARIANT 195 195 Y -> H (in allele B*56:05 and allele FT B*56:06). FT /FTId=VAR_016494. SQ SEQUENCE 362 AA; 40478 MW; D442225B8A09D667 CRC64; MRVTAPRTLL LLLWGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTWQ TMYGCDLGPD GRLLRGHNQL AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B57_HUMAN Reviewed; 362 AA. AC P18465; O62917; P30497; P79496; Q29679; Q5QT24; DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1990, sequence version 1. DT 12-SEP-2018, entry version 159. DE RecName: Full=HLA class I histocompatibility antigen, B-57 alpha chain; DE AltName: Full=Bw-57; DE AltName: Full=MHC class I antigen B*57; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*57:01). RX PubMed=2320591; DOI=10.1073/pnas.87.7.2833; RA Ennis P.D., Zemmour J., Salter R.D., Parham P.; RT "Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: RT frequency and nature of errors produced in amplification."; RL Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*57:01). RX PubMed=2251138; DOI=10.1093/nar/18.22.6702; RA Isamat M., Girdlestone J., Milstein C.; RT "Nucleotide sequence of an HLA-Bw57 gene."; RL Nucleic Acids Res. 18:6702-6702(1990). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Cox S.T.; RT "Confirmation of B*5701."; RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*57:02). RX PubMed=1431115; RA Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J., RA Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., RA Martell R.W., du Toit E.D., Parham P.; RT "Distinctive HLA-A,B antigens of black populations formed by RT interallelic conversion."; RL J. Immunol. 149:3411-3415(1992). RN [5] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*57:03). RC TISSUE=Blood; RA Petersdorf E.; RT "Molecular diversity of HLA-B."; RL Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*57:03). RX PubMed=9234488; DOI=10.1111/j.1399-0039.1997.tb02814.x; RA Vilches C., Bunce M., de Pablo R., Moreno M.E., Puente S., Sanz L., RA Kreisler M.; RT "The novel HLA-Cw*1802 allele is associated with B*5703 in the Bubi RT population from Equatorial Guinea."; RL Tissue Antigens 49:644-648(1997). RN [7] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*57:05). RX PubMed=11556976; DOI=10.1034/j.1399-0039.2001.057005481.x; RA Steiner N.K., Kosman C., Jones P.F., Gans C.P., Rodriguez-Marino S.G., RA Rizzuto G., Baldassarre L.A., Edson S., Koester R., Sese D., RA Mitton W., Ng J., Hartzman R.J., Hurley C.K.; RT "Twenty-nine new HLA-B alleles associated with antigens in the 5C RT CREG."; RL Tissue Antigens 57:481-485(2001). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [9] RP X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 25-300 (ALLELE B*57:03) IN RP COMPLEX WITH HIV-1 PEPTIDES, AND DISULFIDE BONDS. RX PubMed=16081817; DOI=10.4049/jimmunol.175.4.2459; RA Stewart-Jones G.B., Gillespie G., Overton I.M., Kaul R., Roche P., RA McMichael A.J., Rowland-Jones S., Jones E.Y.; RT "Structures of three HIV-1 HLA-B*5703-peptide complexes and RT identification of related HLAs potentially associated with long-term RT nonprogression."; RL J. Immunol. 175:2459-2468(2005). RN [10] RP VARIANT [LARGE SCALE ANALYSIS] TYR-140, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- INTERACTION: CC Q14943:KIR3DS1; NbExp=7; IntAct=EBI-6163561, EBI-15316524; CC Q8N423:LILRB2; NbExp=2; IntAct=EBI-6163561, EBI-2816428; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-57 are known: B*57:01, CC B*57:02 (Bw57.2), B*57:03 (B-57SAU) and B*57:05. The sequence CC shown is that of B*57:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M32318; AAA36231.1; -; mRNA. DR EMBL; X55711; CAA39244.1; -; Genomic_DNA. DR EMBL; AJ458991; CAD30339.1; -; Genomic_DNA. DR EMBL; X61707; CAA43876.1; -; mRNA. DR EMBL; U18790; AAB60361.1; -; mRNA. DR EMBL; Y09157; CAA70355.1; -; mRNA. DR EMBL; AH006370; AAC32568.1; -; Genomic_DNA. DR PIR; D35997; D35997. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 2BVO; X-ray; 1.65 A; A=25-300. DR PDB; 2BVP; X-ray; 1.35 A; A=25-300. DR PDB; 2BVQ; X-ray; 2.00 A; A=25-300. DR PDB; 2HJL; X-ray; 1.50 A; A=25-298. DR PDB; 2RFX; X-ray; 2.50 A; A=25-299. DR PDB; 2YPK; X-ray; 1.95 A; A=25-298. DR PDB; 2YPL; X-ray; 2.40 A; A=25-298. DR PDB; 3UPR; X-ray; 2.00 A; A/C=25-300. DR PDB; 3VH8; X-ray; 1.80 A; A/D=25-299. DR PDB; 3VRI; X-ray; 1.60 A; A=25-300. DR PDB; 3VRJ; X-ray; 1.90 A; A=25-300. DR PDB; 3WUW; X-ray; 2.00 A; A=25-299. DR PDB; 3X11; X-ray; 2.15 A; A=25-300. DR PDB; 3X12; X-ray; 1.80 A; A=25-300. DR PDB; 5B38; X-ray; 2.30 A; A=25-300. DR PDB; 5B39; X-ray; 2.50 A; A=25-300. DR PDB; 5T6W; X-ray; 1.90 A; A=25-300. DR PDB; 5T6X; X-ray; 1.69 A; A=25-300. DR PDB; 5T6Y; X-ray; 1.76 A; A=25-300. DR PDB; 5T6Z; X-ray; 2.00 A; A=25-300. DR PDB; 5T70; X-ray; 2.10 A; A=25-300. DR PDB; 5U98; X-ray; 2.00 A; A/D=25-300. DR PDB; 5V5M; X-ray; 2.88 A; A/C=25-300. DR PDB; 6BXP; X-ray; 1.45 A; A=25-300. DR PDB; 6BXQ; X-ray; 1.58 A; B=25-300. DR PDBsum; 2BVO; -. DR PDBsum; 2BVP; -. DR PDBsum; 2BVQ; -. DR PDBsum; 2HJL; -. DR PDBsum; 2RFX; -. DR PDBsum; 2YPK; -. DR PDBsum; 2YPL; -. DR PDBsum; 3UPR; -. DR PDBsum; 3VH8; -. DR PDBsum; 3VRI; -. DR PDBsum; 3VRJ; -. DR PDBsum; 3WUW; -. DR PDBsum; 3X11; -. DR PDBsum; 3X12; -. DR PDBsum; 5B38; -. DR PDBsum; 5B39; -. DR PDBsum; 5T6W; -. DR PDBsum; 5T6X; -. DR PDBsum; 5T6Y; -. DR PDBsum; 5T6Z; -. DR PDBsum; 5T70; -. DR PDBsum; 5U98; -. DR PDBsum; 5V5M; -. DR PDBsum; 6BXP; -. DR PDBsum; 6BXQ; -. DR ProteinModelPortal; P18465; -. DR SMR; P18465; -. DR IntAct; P18465; 10. DR SwissPalm; P18465; -. DR DMDM; 122174; -. DR MaxQB; P18465; -. DR PeptideAtlas; P18465; -. DR PRIDE; P18465; -. DR Ensembl; ENST00000435618; ENSP00000405178; ENSG00000224608. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P18465; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR EvolutionaryTrace; P18465; -. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0042270; P:protection from natural killer cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-57 alpha chain. FT /FTId=PRO_0000018860. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:16081817}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:16081817}. FT VARIANT 121 121 V -> R (in allele B*57:05; requires 2 FT nucleotide substitutions). FT /FTId=VAR_016669. FT VARIANT 127 127 V -> L (in allele B*57:05). FT /FTId=VAR_016670. FT VARIANT 137 137 H -> Y (in allele B*57:05). FT /FTId=VAR_016671. FT VARIANT 138 138 D -> N (in allele B*57:02, allele B*57:03 FT and allele B*57:05). FT /FTId=VAR_016495. FT VARIANT 140 140 S -> Y (in allele B*57:02, allele B*57:03 FT and allele B*57:05). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_016496. FT VARIANT 180 180 L -> R (in allele B*57:02 and allele FT B*57:05). FT /FTId=VAR_016497. FT VARIANT 306 306 V -> I (in dbSNP:rs1131500). FT /FTId=VAR_056416. FT VARIANT 329 329 A -> T (in dbSNP:rs1051488). FT /FTId=VAR_056417. FT VARIANT 349 349 C -> S (in dbSNP:rs2308655). FT /FTId=VAR_061431. FT VARIANT 349 349 C -> Y (in dbSNP:rs2308655). FT /FTId=VAR_061432. FT STRAND 27 36 {ECO:0000244|PDB:2BVP}. FT STRAND 41 43 {ECO:0000244|PDB:2BVP}. FT STRAND 45 52 {ECO:0000244|PDB:2BVP}. FT STRAND 55 61 {ECO:0000244|PDB:2BVP}. FT STRAND 64 66 {ECO:0000244|PDB:2BVP}. FT HELIX 74 76 {ECO:0000244|PDB:2BVP}. FT HELIX 81 108 {ECO:0000244|PDB:2BVP}. FT STRAND 113 115 {ECO:0000244|PDB:5T6X}. FT STRAND 118 127 {ECO:0000244|PDB:2BVP}. FT STRAND 129 131 {ECO:0000244|PDB:5T70}. FT STRAND 133 142 {ECO:0000244|PDB:2BVP}. FT STRAND 145 150 {ECO:0000244|PDB:2BVP}. FT STRAND 157 161 {ECO:0000244|PDB:2BVP}. FT HELIX 162 173 {ECO:0000244|PDB:2BVP}. FT HELIX 176 185 {ECO:0000244|PDB:2BVP}. FT HELIX 187 198 {ECO:0000244|PDB:2BVP}. FT HELIX 200 203 {ECO:0000244|PDB:2BVP}. FT STRAND 210 219 {ECO:0000244|PDB:2BVP}. FT STRAND 222 235 {ECO:0000244|PDB:2BVP}. FT STRAND 238 243 {ECO:0000244|PDB:2BVP}. FT HELIX 249 251 {ECO:0000244|PDB:2BVP}. FT STRAND 252 254 {ECO:0000244|PDB:5B39}. FT STRAND 261 263 {ECO:0000244|PDB:2BVP}. FT STRAND 265 274 {ECO:0000244|PDB:2BVP}. FT HELIX 278 280 {ECO:0000244|PDB:2BVP}. FT STRAND 281 286 {ECO:0000244|PDB:2BVP}. FT STRAND 290 292 {ECO:0000244|PDB:2BVP}. FT STRAND 294 296 {ECO:0000244|PDB:2BVP}. SQ SEQUENCE 362 AA; 40224 MW; C1EFCF089096AFF9 CRC64; MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRMA PRAPWIEQEG PEYWDGETRN MKASAQTYRE NLRIALRYYN QSEAGSHIIQ VMYGCDVGPD GRLLRGHDQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA // ID 1B58_HUMAN Reviewed; 362 AA. AC P10319; Q29925; Q9TP35; Q9TPS6; DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1989, sequence version 1. DT 12-SEP-2018, entry version 152. DE RecName: Full=HLA class I histocompatibility antigen, B-58 alpha chain; DE AltName: Full=Bw-58; DE AltName: Full=MHC class I antigen B*58; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*58:01). RX PubMed=2995352; RA Ways J.P., Coppin H.L., Parham P.; RT "The complete primary structure of HLA-Bw58."; RL J. Biol. Chem. 260:11924-11933(1985). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE B*58:01). RC TISSUE=Blood; RA Inoue T., Ogawa A.; RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*58:02). RX PubMed=7761977; DOI=10.1111/j.1399-0039.1995.tb02437.x; RA Browning M.J., Madrigal J.A., Krausa P., Kowalski H., Allsopp C.E., RA Little A.-M., Turner S., Adams E.J., Arnett K.L., Bodmer W.F., RA Parham P.; RT "The HLA-A,B,C genotype of the class I negative cell line Daudi RT reveals novel HLA-A and -B alleles."; RL Tissue Antigens 45:177-187(1995). RN [4] RP NUCLEOTIDE SEQUENCE OF 1-206 (ALLELE B*58:04). RX PubMed=12392514; DOI=10.1034/j.1399-0039.2002.600210.x; RA Williams T.M., Wu J., Bassinger S., Feldman D., Birkos S., Kearns J., RA Kamoun M.; RT "New HLA-B alleles identified and sequences extended in potential bone RT marrow donors: B*5804, B*4418, B*1558, and B*4805."; RL Tissue Antigens 60:186-188(2002). RN [5] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*58:05). RX PubMed=11556976; DOI=10.1034/j.1399-0039.2001.057005481.x; RA Steiner N.K., Kosman C., Jones P.F., Gans C.P., Rodriguez-Marino S.G., RA Rizzuto G., Baldassarre L.A., Edson S., Koester R., Sese D., RA Mitton W., Ng J., Hartzman R.J., Hurley C.K.; RT "Twenty-nine new HLA-B alleles associated with antigens in the 5C RT CREG."; RL Tissue Antigens 57:481-485(2001). RN [6] RP ASSOCIATION OF ALLELE B*58:01 WITH SEVERE CUTANEOUS ADVERSE REACTIONS RP TO ALLOPURINOL. RX PubMed=15743917; DOI=10.1073/pnas.0409500102; RA Hung S.I., Chung W.H., Liou L.B., Chu C.C., Lin M., Huang H.P., RA Lin Y.L., Lan J.L., Yang L.C., Hong H.S., Chen M.J., Lai P.C., RA Wu M.S., Chu C.Y., Wang K.H., Chen C.H., Fann C.S., Wu J.Y., RA Chen Y.T.; RT "HLA-B*5801 allele as a genetic marker for severe cutaneous adverse RT reactions caused by allopurinol."; RL Proc. Natl. Acad. Sci. U.S.A. 102:4134-4139(2005). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-58 are known: B*58:01, CC B*58:02, B*58:04 and B*58:05. The sequence shown is that of CC B*58:01. Allele B*58:01 is an important genetic risk factor for CC severe cutaneous adverse reactions to allopurinol in the Han CC Chinese population [MIM:608579]. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M11799; AAA59628.1; -; Genomic_DNA. DR EMBL; AB008102; BAA22916.1; -; mRNA. DR EMBL; L33923; AAA74406.1; -; mRNA. DR EMBL; AH008324; AAF04579.1; -; Genomic_DNA. DR EMBL; AH008968; AAF21438.1; -; Genomic_DNA. DR PIR; A23895; HLHUB8. DR PIR; I84490; I84490. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 5IM7; X-ray; 2.50 A; A/C=25-300. DR PDB; 5INC; X-ray; 2.88 A; A/C=25-300. DR PDB; 5IND; X-ray; 2.13 A; A/C=25-300. DR PDB; 5V5L; X-ray; 2.00 A; A/C=25-300. DR PDBsum; 5IM7; -. DR PDBsum; 5INC; -. DR PDBsum; 5IND; -. DR PDBsum; 5V5L; -. DR ProteinModelPortal; P10319; -. DR SMR; P10319; -. DR IntAct; P10319; 1. DR SwissPalm; P10319; -. DR DMDM; 122168; -. DR MaxQB; P10319; -. DR PeptideAtlas; P10319; -. DR PRIDE; P10319; -. DR Ensembl; ENST00000435618; ENSP00000405178; ENSG00000224608. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR MIM; 608579; phenotype. DR neXtProt; NX_P10319; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-58 alpha chain. FT /FTId=PRO_0000018861. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 86 86 G -> E (in allele B*58:04). FT /FTId=VAR_016498. FT VARIANT 118 119 II -> TL (in allele B*58:02). FT /FTId=VAR_016499. FT VARIANT 121 121 R -> W (in allele B*58:02). FT /FTId=VAR_016500. FT VARIANT 171 171 W -> L (in allele B*58:05). FT /FTId=VAR_016666. FT VARIANT 176 176 V -> A (in allele B*58:05). FT /FTId=VAR_016667. FT VARIANT 187 187 L -> T (in allele B*58:05; requires 2 FT nucleotide substitutions). FT /FTId=VAR_016668. FT STRAND 27 36 {ECO:0000244|PDB:5V5L}. FT TURN 39 41 {ECO:0000244|PDB:5V5L}. FT STRAND 45 52 {ECO:0000244|PDB:5V5L}. FT STRAND 55 61 {ECO:0000244|PDB:5V5L}. FT STRAND 64 66 {ECO:0000244|PDB:5V5L}. FT STRAND 69 71 {ECO:0000244|PDB:5INC}. FT HELIX 74 76 {ECO:0000244|PDB:5V5L}. FT HELIX 81 109 {ECO:0000244|PDB:5V5L}. FT STRAND 113 115 {ECO:0000244|PDB:5IM7}. FT STRAND 118 127 {ECO:0000244|PDB:5V5L}. FT STRAND 131 142 {ECO:0000244|PDB:5V5L}. FT STRAND 145 150 {ECO:0000244|PDB:5V5L}. FT STRAND 157 161 {ECO:0000244|PDB:5V5L}. FT HELIX 162 173 {ECO:0000244|PDB:5V5L}. FT HELIX 176 185 {ECO:0000244|PDB:5V5L}. FT HELIX 187 198 {ECO:0000244|PDB:5V5L}. FT HELIX 200 203 {ECO:0000244|PDB:5V5L}. FT STRAND 210 235 {ECO:0000244|PDB:5V5L}. FT STRAND 238 243 {ECO:0000244|PDB:5V5L}. FT HELIX 249 251 {ECO:0000244|PDB:5V5L}. FT STRAND 252 254 {ECO:0000244|PDB:5IND}. FT STRAND 261 263 {ECO:0000244|PDB:5V5L}. FT STRAND 265 274 {ECO:0000244|PDB:5V5L}. FT HELIX 278 280 {ECO:0000244|PDB:5V5L}. FT STRAND 281 286 {ECO:0000244|PDB:5V5L}. FT STRAND 290 292 {ECO:0000244|PDB:5IND}. FT STRAND 294 296 {ECO:0000244|PDB:5V5L}. SQ SEQUENCE 362 AA; 40337 MW; 2056116240BB9AC0 CRC64; MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRTE PRAPWIEQEG PEYWDGETRN MKASAQTYRE NLRIALRYYN QSEAGSHIIQ RMYGCDLGPD GRLLRGHDQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B59_HUMAN Reviewed; 362 AA. AC Q29940; O02957; DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 12-SEP-2018, entry version 130. DE RecName: Full=HLA class I histocompatibility antigen, B-59 alpha chain; DE AltName: Full=MHC class I antigen B*59; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*59:01). RX PubMed=8362411; DOI=10.1111/j.1399-0039.1993.tb02001.x; RA Hildebrand W.H., Domena J.D., Parham P.; RT "Primary structure shows HLA-B59 to be a hybrid of HLA-B55 and HLA- RT B51, and not a subtype of HLA-B8."; RL Tissue Antigens 41:190-195(1993). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*59:01). RC TISSUE=Blood; RA Lin L., Tokunaga K.; RL Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases. RN [3] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [4] RP VARIANT [LARGE SCALE ANALYSIS] THR-65, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; L07743; AAA59621.1; -; mRNA. DR EMBL; D50300; BAA08829.1; -; mRNA. DR PIR; I59633; I59633. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; Q29940; -. DR SMR; Q29940; -. DR IntAct; Q29940; 1. DR SwissPalm; Q29940; -. DR DMDM; 34305704; -. DR EPD; Q29940; -. DR MaxQB; Q29940; -. DR PeptideAtlas; Q29940; -. DR PRIDE; Q29940; -. DR Ensembl; ENST00000359635; ENSP00000352656; ENSG00000206450. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_Q29940; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-59 alpha chain. FT /FTId=PRO_0000018862. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 65 65 A -> T (in dbSNP:rs1050529). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056418. FT VARIANT 87 87 N -> D (in dbSNP:rs1050570). FT /FTId=VAR_056419. FT VARIANT 87 87 N -> K (in dbSNP:rs1065386). FT /FTId=VAR_059493. SQ SEQUENCE 362 AA; 40584 MW; F07B384BC182A3B1 CRC64; MRVTAPRTLL LLLWGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI FKTNTQTYRE NLRIALRYYN QSEAGSHTWQ TMYGCDLGPD GRLLRGHNQL AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B67_HUMAN Reviewed; 362 AA. AC Q29836; Q29678; Q8SNC5; Q95IA6; Q9BD38; DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 12-SEP-2018, entry version 144. DE RecName: Full=HLA class I histocompatibility antigen, B-67 alpha chain; DE AltName: Full=MHC class I antigen B*67; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*67:01). RX PubMed=7517584; DOI=10.1111/j.1399-0039.1994.tb02294.x; RA Little A.-M., Domena J.D., Hildebrand W.H., Shen S.Y., Barber L.D., RA Marsh S.G.E., Bias W.B., Parham P.; RT "HLA-B67: a member of the HLA-B16 family that expresses the ME1 RT epitope."; RL Tissue Antigens 43:38-43(1994). RN [2] RP NUCLEOTIDE SEQUENCE OF 26-205 (ALLELE B*67:01). RC TISSUE=Blood; RA Petersdorf E.; RT "Molecular diversity of HLA-B."; RL Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE B*67:02). RA Iglehart B.A., Leffell M.S.; RT "HLA-B*6702 (Promoter-3'UTR)."; RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*67:02). RA Baldassarre L.A., Hurley C.K.; RT "Novel HLA-B allele (HLA-B*67012 variant)."; RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases. RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [6] RP VARIANT [LARGE SCALE ANALYSIS] THR-65, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [7] RP VARIANT [LARGE SCALE ANALYSIS] GLU-87, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-67 are known: B*67:01 (B- CC 67LAV) and B*67:02. The sequence shown is that of B*67:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; L17005; AAC37548.1; -; mRNA. DR EMBL; U18789; AAB60360.1; -; mRNA. DR EMBL; AF487379; AAL93257.1; -; Genomic_DNA. DR EMBL; AH010386; AAK09378.1; -; Genomic_DNA. DR EMBL; AH011166; AAL18235.1; -; Genomic_DNA. DR PIR; I59645; I59645. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; Q29836; -. DR SMR; Q29836; -. DR SwissPalm; Q29836; -. DR DMDM; 34222510; -. DR MaxQB; Q29836; -. DR PeptideAtlas; Q29836; -. DR PRIDE; Q29836; -. DR Ensembl; ENST00000412585; ENSP00000399168; ENSG00000234745. DR DisGeNET; 3106; -. DR EuPathDB; HostDB:ENSG00000234745.9; -. DR GeneCards; HLA-B; -. DR H-InvDB; HIX0164788; -. DR HGNC; HGNC:4932; HLA-B. DR HPA; CAB015418; -. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_Q29836; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000234745; Expressed in 92 organ(s), highest expression level in blood. DR CleanEx; HS_HLA-B; -. DR ExpressionAtlas; Q29836; baseline and differential. DR Genevisible; Q29836; HS. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-67 alpha chain. FT /FTId=PRO_0000018863. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 4 4 M -> T (in dbSNP:rs1050458). FT /FTId=VAR_056420. FT VARIANT 9 9 V -> L (in dbSNP:rs1050462). FT /FTId=VAR_056421. FT VARIANT 17 17 L -> V (in dbSNP:rs1131165). FT /FTId=VAR_056422. FT VARIANT 35 35 S -> A (in dbSNP:rs1131170). FT /FTId=VAR_056423. FT VARIANT 36 36 V -> M (in dbSNP:rs1050486). FT /FTId=VAR_056424. FT VARIANT 48 48 S -> A (in dbSNP:rs713031). FT /FTId=VAR_061433. FT VARIANT 48 48 S -> P (in dbSNP:rs713031). FT /FTId=VAR_061434. FT VARIANT 48 48 S -> T (in dbSNP:rs713031). FT /FTId=VAR_061435. FT VARIANT 65 65 A -> T (in dbSNP:rs1050529). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056425. FT VARIANT 69 69 E -> G (in allele B*67:02). FT /FTId=VAR_016536. FT VARIANT 76 76 I -> V (in allele B*67:02). FT /FTId=VAR_016537. FT VARIANT 87 87 N -> D (in dbSNP:rs1050570). FT /FTId=VAR_056426. FT VARIANT 87 87 N -> E (in allele B*67:02; requires 2 FT nucleotide substitutions). FT {ECO:0000244|PubMed:24275569}. FT /FTId=VAR_016538. FT VARIANT 87 87 N -> K (in dbSNP:rs1065386). FT /FTId=VAR_059494. FT VARIANT 90 90 I -> K (in allele B*67:02). FT /FTId=VAR_016539. FT VARIANT 93 93 A -> R (in allele B*67:02; requires 2 FT nucleotide substitutions). FT /FTId=VAR_016540. FT VARIANT 97 97 T -> A (in allele B*67:02; FT dbSNP:rs1050393). FT /FTId=VAR_016541. FT VARIANT 98 98 D -> Y (in dbSNP:rs1131215). FT /FTId=VAR_059495. FT VARIANT 100 100 E -> V (in allele B*67:02). FT /FTId=VAR_016542. FT VARIANT 101 101 S -> N (in dbSNP:rs1050388). FT /FTId=VAR_056427. FT VARIANT 306 306 V -> I (in dbSNP:rs1131500). FT /FTId=VAR_056428. FT VARIANT 329 329 A -> T (in dbSNP:rs1051488). FT /FTId=VAR_056429. SQ SEQUENCE 362 AA; 40342 MW; 3F6A17FC10230F70 CRC64; MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHNQF AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RTYLEGTCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B73_HUMAN Reviewed; 363 AA. AC Q31612; G3GN01; DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 12-SEP-2018, entry version 143. DE RecName: Full=HLA class I histocompatibility antigen, B-73 alpha chain; DE AltName: Full=MHC class I antigen B*73; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*73:01). RX PubMed=7524186; DOI=10.1111/j.1399-0039.1994.tb02344.x; RA Parham P., Arnett K.L., Adams E.J., Barber L.D., Domena J.D., RA Stewart D., Hildebrand W.H., Little A.-M.; RT "The HLA-B73 antigen has a most unusual structure that defines a RT second lineage of HLA-B alleles."; RL Tissue Antigens 43:302-313(1994). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*73:01). RX PubMed=7517915; DOI=10.1007/BF00188185; RA Vilches C., de Pablo R., Herrero M.J., Moreno M.E., Kreisler M.; RT "HLA-B73: an atypical HLA-B molecule carrying a Bw6-epitope motif RT variant and a B pocket identical to HLA-B27."; RL Immunogenetics 40:166-166(1994). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*73:01). RX PubMed=8547229; DOI=10.1111/j.1744-313X.1995.tb00237.x; RA Hoffmann H.J., Kristensen T.J., Jensen T.G., Graugaard B., Lamm L.U.; RT "Antigenic characteristics and cDNA sequences of HLA-B73."; RL Eur. J. Immunogenet. 22:231-240(1995). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*73:01). RC TISSUE=Blood; RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*73:01). RX PubMed=21868630; DOI=10.1126/science.1209202; RA Abi-Rached L., Jobin M.J., Kulkarni S., McWhinnie A., Dalva K., RA Gragert L., Babrzadeh F., Gharizadeh B., Luo M., Plummer F.A., RA Kimani J., Carrington M., Middleton D., Rajalingam R., Beksac M., RA Marsh S.G., Maiers M., Guethlein L.A., Tavoularis S., Little A.M., RA Green R.E., Norman P.J., Parham P.; RT "The shaping of modern human immune systems by multiregional admixture RT with archaic humans."; RL Science 334:89-94(2011). RN [6] RP VARIANT [LARGE SCALE ANALYSIS] THR-65, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [7] RP VARIANT [LARGE SCALE ANALYSIS] SER-155, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- INTERACTION: CC P43628:KIR2DL3; NbExp=2; IntAct=EBI-9978548, EBI-8632435; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; U04787; AAA53175.1; -; mRNA. DR EMBL; X77658; CAA54739.1; -; mRNA. DR EMBL; L24373; AAA96733.1; -; mRNA. DR EMBL; AJ311601; CAC35319.2; -; Genomic_DNA. DR EMBL; JF974053; AEN79482.1; -; Genomic_DNA. DR PIR; I37512; S42102. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; Q31612; -. DR SMR; Q31612; -. DR IntAct; Q31612; 6. DR iPTMnet; Q31612; -. DR PhosphoSitePlus; Q31612; -. DR SwissPalm; Q31612; -. DR DMDM; 34222512; -. DR PeptideAtlas; Q31612; -. DR PRIDE; Q31612; -. DR Ensembl; ENST00000412585; ENSP00000399168; ENSG00000234745. DR UCSC; uc003nth.3; human. DR DisGeNET; 3106; -. DR EuPathDB; HostDB:ENSG00000234745.9; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR HPA; CAB015418; -. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_Q31612; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; Q31612; -. DR OrthoDB; EOG091G09OH; -. DR PhylomeDB; Q31612; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000234745; Expressed in 92 organ(s), highest expression level in blood. DR CleanEx; HS_HLA-B; -. DR ExpressionAtlas; Q31612; baseline and differential. DR Genevisible; Q31612; HS. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 363 HLA class I histocompatibility antigen, FT B-73 alpha chain. FT /FTId=PRO_0000018864. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 363 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 4 4 M -> T (in dbSNP:rs1050458). FT /FTId=VAR_056430. FT VARIANT 9 9 V -> L (in dbSNP:rs1050462). FT /FTId=VAR_056431. FT VARIANT 17 17 L -> V (in dbSNP:rs1131165). FT /FTId=VAR_056432. FT VARIANT 65 65 A -> T (in dbSNP:rs1050529). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056433. FT VARIANT 87 87 N -> D (in dbSNP:rs1050570). FT /FTId=VAR_056434. FT VARIANT 87 87 N -> K (in dbSNP:rs1065386). FT /FTId=VAR_059496. FT VARIANT 155 155 R -> S (in dbSNP:rs1050654). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_056435. FT CONFLICT 338 339 SG -> C (in Ref. 4; CAC35319). FT {ECO:0000305}. SQ SEQUENCE 363 AA; 40435 MW; 04522E97C1E11C40 CRC64; MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFHTSVSRPG RGEPRFITVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI CKAKAQTDRV GLRNLRGYYN QSEDGSHTWQ TMYGCDMGPD GRLLRGYNQF AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARVAEQL RAYLEGECVE WLRRHLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL QEPCTLRWKP SSQSTIPIVG IVAGLAVLVV TVAVVAVVAA VMCRRKSSGG KGGSYSQAAS SDSAQGSDVS LTA // ID 1B78_HUMAN Reviewed; 362 AA. AC P30498; O62915; Q29924; Q546M4; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 139. DE RecName: Full=HLA class I histocompatibility antigen, B-78 alpha chain; DE AltName: Full=MHC class I antigen B*78; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE B*78:01). RX PubMed=1431115; RA Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J., RA Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., RA Martell R.W., du Toit E.D., Parham P.; RT "Distinctive HLA-A,B antigens of black populations formed by RT interallelic conversion."; RL J. Immunol. 149:3411-3415(1992). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*78:01). RX PubMed=1691230; RA Sekimata M., Hiraiwa M., Andrien M., Dupont E., Karaki S., RA Yamamoto J., Kano K., Takiguchi M.; RT "Allodeterminants and evolution of a novel HLA-B5 CREG antigen, HLA-B RT SNA."; RL J. Immunol. 144:3228-3233(1990). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*78:02). RX PubMed=8929712; DOI=10.1111/j.1399-0039.1996.tb02513.x; RA Prilliman K., Steiner N.K., Ellexson M., Stewart D., Lau M., RA Terasaki P., Hurley C.K., Hildebrand W.H.; RT "Novel alleles HLA-B*7802 and B*51022: evidence for convergency in the RT HLA-B5 family."; RL Tissue Antigens 47:49-57(1996). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*78:01). RC TISSUE=Blood; RA Cox S.T.; RT "Confirmation of B*7801."; RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*78:03). RX PubMed=11556976; DOI=10.1034/j.1399-0039.2001.057005481.x; RA Steiner N.K., Kosman C., Jones P.F., Gans C.P., Rodriguez-Marino S.G., RA Rizzuto G., Baldassarre L.A., Edson S., Koester R., Sese D., RA Mitton W., Ng J., Hartzman R.J., Hurley C.K.; RT "Twenty-nine new HLA-B alleles associated with antigens in the 5C RT CREG."; RL Tissue Antigens 57:481-485(2001). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-78 are known: B*78:01 (B CC SNA), B*78:02 and B*78:03. The sequence shown is that of B*78:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X61708; CAA43877.1; -; mRNA. DR EMBL; M33573; AAA59644.1; -; Genomic_DNA. DR EMBL; L41214; AAC41980.1; -; mRNA. DR EMBL; AJ309192; CAC38391.1; -; Genomic_DNA. DR EMBL; AH006368; AAC32566.1; -; Genomic_DNA. DR PIR; I37522; I37522. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; P30498; -. DR SMR; P30498; -. DR SwissPalm; P30498; -. DR DMDM; 231421; -. DR MaxQB; P30498; -. DR PeptideAtlas; P30498; -. DR PRIDE; P30498; -. DR Ensembl; ENST00000359635; ENSP00000352656; ENSG00000206450. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_P30498; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-78 alpha chain. FT /FTId=PRO_0000018865. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 91 91 F -> C (in allele B*78:03). FT /FTId=VAR_016672. FT VARIANT 97 97 T -> A (in dbSNP:rs1050393). FT /FTId=VAR_056436. FT VARIANT 98 98 D -> Y (in allele B*78:02). FT /FTId=VAR_016501. SQ SEQUENCE 362 AA; 40478 MW; D2D6142768F28E6C CRC64; MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRTE PRAPWIEQEG PEYWDRNTQI FKTNTQTDRE SLRNLRGYYN QSEAGSHTWQ TMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQL RAYLEGLCVE WLRRHLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1B81_HUMAN Reviewed; 362 AA. AC Q31610; DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 12-SEP-2018, entry version 142. DE RecName: Full=HLA class I histocompatibility antigen, B-81 alpha chain; DE AltName: Full=B'DT; DE AltName: Full=MHC class I antigen B*81; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*81:01). RX PubMed=8847228; DOI=10.1016/0198-8859(95)00082-F; RA Ellexson M.E., Zhang G., Stewart D., Lau M., Teresi G., Terasaki P., RA Roe B.A., Hildebrand W.H.; RT "Nucleotide sequence analysis of HLA-B*1523 and B*8101. Dominant RT alpha-helical motifs produce complex serologic recognition patterns RT for the HLA-B''DT'' and HLA-B''NM5'' antigens."; RL Hum. Immunol. 44:103-110(1995). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*81:01). RX PubMed=8851728; DOI=10.1111/j.1399-0039.1996.tb02527.x; RA Vilches C., Sanz L., de Pablo R., Moreno M.E., Puente S., Kreisler M.; RT "Molecular characterization of the new alleles HLA-B*8101 and RT B*4407."; RL Tissue Antigens 47:139-142(1996). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*81:01). RA Hildebrand W.H., Ellexson M.E.; RT "HLA-B'DT', a class I allele most homologous with HLA-B-4801."; RL Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases. RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] RP VARIANT [LARGE SCALE ANALYSIS] THR-65, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; L37880; AAC41941.1; -; mRNA. DR EMBL; X90390; CAA62035.1; -; mRNA. DR EMBL; U09912; AAF70855.1; -; mRNA. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR PDB; 4U1I; X-ray; 1.92 A; A=25-301. DR PDB; 4U1L; X-ray; 2.06 A; A/D=25-300. DR PDB; 4U1S; X-ray; 1.76 A; A=25-301. DR PDBsum; 4U1I; -. DR PDBsum; 4U1L; -. DR PDBsum; 4U1S; -. DR ProteinModelPortal; Q31610; -. DR SMR; Q31610; -. DR SwissPalm; Q31610; -. DR MaxQB; Q31610; -. DR PeptideAtlas; Q31610; -. DR PRIDE; Q31610; -. DR Ensembl; ENST00000412585; ENSP00000399168; ENSG00000234745. DR DisGeNET; 3106; -. DR EuPathDB; HostDB:ENSG00000234745.9; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR HPA; CAB015418; -. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_Q31610; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000234745; Expressed in 92 organ(s), highest expression level in blood. DR CleanEx; HS_HLA-B; -. DR ExpressionAtlas; Q31610; baseline and differential. DR Genevisible; Q31610; HS. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-81 alpha chain. FT /FTId=PRO_0000018866. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 4 4 M -> T (in dbSNP:rs1050458). FT /FTId=VAR_056437. FT VARIANT 9 9 V -> L (in dbSNP:rs1050462). FT /FTId=VAR_056438. FT VARIANT 35 35 S -> A (in dbSNP:rs1131170). FT /FTId=VAR_056439. FT VARIANT 36 36 V -> M (in dbSNP:rs1050486). FT /FTId=VAR_056440. FT VARIANT 48 48 S -> A (in dbSNP:rs713031). FT /FTId=VAR_061436. FT VARIANT 48 48 S -> P (in dbSNP:rs713031). FT /FTId=VAR_061437. FT VARIANT 48 48 S -> T (in dbSNP:rs713031). FT /FTId=VAR_061438. FT VARIANT 65 65 A -> T (in dbSNP:rs1050529). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056441. FT VARIANT 87 87 N -> D (in dbSNP:rs1050570). FT /FTId=VAR_056442. FT VARIANT 87 87 N -> K (in dbSNP:rs1065386). FT /FTId=VAR_059497. FT VARIANT 97 97 T -> A (in dbSNP:rs1050393). FT /FTId=VAR_056443. FT VARIANT 98 98 D -> Y (in dbSNP:rs1131215). FT /FTId=VAR_059498. FT VARIANT 101 101 S -> N (in dbSNP:rs1050388). FT /FTId=VAR_056444. FT VARIANT 137 137 H -> Y (in dbSNP:rs1050379). FT /FTId=VAR_056445. FT VARIANT 155 155 R -> S (in dbSNP:rs1050654). FT /FTId=VAR_056446. FT VARIANT 187 187 E -> A (in dbSNP:rs2308466). FT /FTId=VAR_059499. FT VARIANT 187 187 E -> G (in dbSNP:rs2308466). FT /FTId=VAR_059500. FT VARIANT 187 187 E -> K (in dbSNP:rs2523600). FT /FTId=VAR_059501. FT VARIANT 187 187 E -> Q (in dbSNP:rs2523600). FT /FTId=VAR_059502. FT VARIANT 187 187 E -> V (in dbSNP:rs2308466). FT /FTId=VAR_059503. FT VARIANT 195 195 Y -> H (in dbSNP:rs1050696). FT /FTId=VAR_056447. FT VARIANT 306 306 V -> I (in dbSNP:rs1131500). FT /FTId=VAR_056448. FT VARIANT 329 329 A -> T (in dbSNP:rs1051488). FT /FTId=VAR_056449. FT VARIANT 349 349 C -> S (in dbSNP:rs2308655). FT /FTId=VAR_061439. FT VARIANT 349 349 C -> Y (in dbSNP:rs2308655). FT /FTId=VAR_061440. FT STRAND 27 36 {ECO:0000244|PDB:4U1S}. FT STRAND 41 43 {ECO:0000244|PDB:4U1L}. FT STRAND 45 52 {ECO:0000244|PDB:4U1S}. FT STRAND 55 61 {ECO:0000244|PDB:4U1S}. FT STRAND 64 66 {ECO:0000244|PDB:4U1S}. FT HELIX 74 76 {ECO:0000244|PDB:4U1S}. FT HELIX 81 108 {ECO:0000244|PDB:4U1S}. FT STRAND 113 115 {ECO:0000244|PDB:4U1L}. FT STRAND 118 127 {ECO:0000244|PDB:4U1S}. FT STRAND 133 142 {ECO:0000244|PDB:4U1S}. FT STRAND 145 150 {ECO:0000244|PDB:4U1S}. FT STRAND 157 161 {ECO:0000244|PDB:4U1S}. FT HELIX 162 173 {ECO:0000244|PDB:4U1S}. FT HELIX 176 185 {ECO:0000244|PDB:4U1S}. FT HELIX 187 197 {ECO:0000244|PDB:4U1S}. FT HELIX 200 203 {ECO:0000244|PDB:4U1S}. FT STRAND 210 217 {ECO:0000244|PDB:4U1S}. FT STRAND 219 235 {ECO:0000244|PDB:4U1S}. FT STRAND 238 243 {ECO:0000244|PDB:4U1S}. FT STRAND 246 248 {ECO:0000244|PDB:4U1S}. FT STRAND 252 254 {ECO:0000244|PDB:4U1S}. FT STRAND 261 263 {ECO:0000244|PDB:4U1S}. FT STRAND 265 274 {ECO:0000244|PDB:4U1S}. FT TURN 275 277 {ECO:0000244|PDB:4U1L}. FT HELIX 278 280 {ECO:0000244|PDB:4U1S}. FT STRAND 281 286 {ECO:0000244|PDB:4U1S}. FT STRAND 294 296 {ECO:0000244|PDB:4U1S}. SQ SEQUENCE 362 AA; 40400 MW; CB2660A583C8A0D8 CRC64; MLVMAPRTVL LLLWGAVALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQISQRK LEAARVAEQL RAYLEGECVE WLRRYLENGK DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWTA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA // ID 1B82_HUMAN Reviewed; 362 AA. AC Q29718; Q29695; Q29742; Q8MHN4; Q9MY61; Q9MYB8; DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 12-SEP-2018, entry version 136. DE RecName: Full=HLA class I histocompatibility antigen, B-82 alpha chain; DE AltName: Full=MHC class I antigen B*82; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ALLELE B*82:01). RX PubMed=8740766; DOI=10.1111/j.1399-0039.1996.tb02538.x; RA Hurley C.K., Steiner N.K., Hoyer R.J., Menchaca E., Mitton W., RA Simonis T., Hartzman R.J., Johnson A.H., Ng J.; RT "Novel HLA-B alleles, B*8201, B*3515 and B*5106, add to the complexity RT of serologic identification of HLA types."; RL Tissue Antigens 47:179-187(1996). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE B*82:01). RA Ellexson M.E., Hildebrand W.H.; RL Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE OF 1-24 (ALLELE B*82:01). RA Blasczyk R.; RT "Exon 1 sequence of HLA-B*8201."; RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*82:01). RA Chopek M., Nielsen J., Zhang H.; RL Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*82:02). RX PubMed=11019925; DOI=10.1034/j.1399-0039.2000.560216.x; RA Cox S.T., Hossain E., McWhinnie A., Prokupek B.M., Madrigal J.A., RA Little A.-M.; RT "HLA-B*8202 identified in a Caucasoid potential bone marrow donor."; RL Tissue Antigens 56:188-191(2000). RN [6] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*82:02). RA Diviney M., Hepner J., Cantwell L., Boyle A., Kanaan C., RA Holdsworth R., Tait B.; RT "Confirmation of HLA-B*8202."; RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases. RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [8] RP VARIANT [LARGE SCALE ANALYSIS] THR-65, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of B-82 are known: B*82:01 and CC B*82:02. The sequence shown is that of B*82:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; U36492; AAB18369.1; -; mRNA. DR EMBL; U29241; AAC50691.1; -; Genomic_DNA. DR EMBL; U38800; AAC99997.1; -; mRNA. DR EMBL; AJ278748; CAC00634.1; -; Genomic_DNA. DR EMBL; U43337; AAA87573.1; -; mRNA. DR EMBL; AJ251755; CAB75360.1; -; Genomic_DNA. DR EMBL; AH011750; AAM83101.1; -; Genomic_DNA. DR UniGene; Hs.654404; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; Q29718; -. DR SMR; Q29718; -. DR SwissPalm; Q29718; -. DR DMDM; 34222509; -. DR MaxQB; Q29718; -. DR PeptideAtlas; Q29718; -. DR PRIDE; Q29718; -. DR Ensembl; ENST00000359635; ENSP00000352656; ENSG00000206450. DR DisGeNET; 3106; -. DR GeneCards; HLA-B; -. DR HGNC; HGNC:4932; HLA-B. DR MalaCards; HLA-B; -. DR MIM; 142830; gene. DR neXtProt; NX_Q29718; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-B; -. DR GO; GO:0009986; C:cell surface; HDA:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-82 alpha chain. FT /FTId=PRO_0000018867. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 48 48 S -> A (in dbSNP:rs713031). FT /FTId=VAR_061441. FT VARIANT 48 48 S -> P (in dbSNP:rs713031). FT /FTId=VAR_061442. FT VARIANT 48 48 S -> T (in dbSNP:rs713031). FT /FTId=VAR_061443. FT VARIANT 65 65 A -> T (in dbSNP:rs1050529). FT {ECO:0000244|PubMed:21269460}. FT /FTId=VAR_056450. FT VARIANT 87 87 N -> D (in dbSNP:rs1050570). FT /FTId=VAR_056451. FT VARIANT 87 87 N -> K (in dbSNP:rs1065386). FT /FTId=VAR_059504. FT VARIANT 97 97 T -> A (in dbSNP:rs1050393). FT /FTId=VAR_056452. FT VARIANT 98 98 D -> Y (in dbSNP:rs1131215). FT /FTId=VAR_059505. FT VARIANT 101 101 S -> N (in dbSNP:rs1050388). FT /FTId=VAR_056453. FT VARIANT 186 186 D -> G (in allele B*82:02). FT /FTId=VAR_016543. SQ SEQUENCE 362 AA; 40421 MW; 273D957D582B3673 CRC64; MRVTAPRTLL LLLWGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFISVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ RMFGCDLGPD GRLLRGHNQL AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQD RAYLEDLCVE SLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID 1C01_GORGO Reviewed; 365 AA. AC P30383; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 25-OCT-2017, entry version 89. DE RecName: Full=Class I histocompatibility antigen, Gogo-C*0101/C*0102 alpha chain; DE Flags: Precursor; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1744581; DOI=10.1084/jem.174.6.1491; RA Lawlor D.A., Warren E., Taylor P., Parham P.; RT "Gorilla class I major histocompatibility complex alleles: comparison RT to human and chimpanzee class I."; RL J. Exp. Med. 174:1491-1509(1991). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X60252; CAA42804.1; -; mRNA. DR EMBL; X60250; CAA42802.1; -; mRNA. DR PIR; JH0544; JH0544. DR ProteinModelPortal; P30383; -. DR SMR; P30383; -. DR PRIDE; P30383; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000001519; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 365 Class I histocompatibility antigen, Gogo- FT C*0101/C*0102 alpha chain. FT /FTId=PRO_0000018905. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 365 AA; 40938 MW; 0DAC1859620B778F CRC64; MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFFTAVAPPG RGEPRFIAVG YVDDTQFVRF DSDAANTRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRKLRGYYN QSEDGSHTFQ RMYGCDVGPD GRLQRGYDQL AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARWAERQ RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEEQTQ DIELVETRPA GDGTFQKWAA MVVPSGEEQR YTCHVQHKGL LEPLTLRWEP SSQPTIPIVG IVAGLAVLAV VFTGTVVAAV MCRRKSSGGK GGSCSQAACS NSAQGSDESL IACKA // ID 1C01_HUMAN Reviewed; 366 AA. AC P30499; O02865; O19676; P30500; Q29986; Q9UQS9; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 143. DE RecName: Full=HLA class I histocompatibility antigen, Cw-1 alpha chain; DE AltName: Full=MHC class I antigen Cw*1; DE Flags: Precursor; GN Name=HLA-C; Synonyms=HLAC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*01:01). RX PubMed=2708822; RA Ellis S.A., Strachan T., Palmer M.S., McMichael A.J.; RT "Complete nucleotide sequence of a unique HLA class I C locus product RT expressed on the human choriocarcinoma cell line BeWo."; RL J. Immunol. 142:3281-3285(1989). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE CW*01:02). RX PubMed=3032784; DOI=10.1007/BF00404424; RA Gussow D., Rein R.S., Meijer I., de Hoog W., Seemann G.H., RA Hochstenbach F.M., Ploegh H.L.; RT "Isolation, expression, and the primary structure of HLA-Cw1 and HLA- RT Cw2 genes: evolutionary aspects."; RL Immunogenetics 25:313-322(1987). RN [3] RP ERRATUM. RA Gussow D., Rein R.S., Meijer I., de Hoog W., Seemann G.H., RA Hochstenbach F.M., Ploegh H.L.; RL Immunogenetics 27:158-158(1988). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*01:02). RX PubMed=1384166; DOI=10.1111/j.1399-0039.1992.tb01943.x; RA Zemmour J., Gumperz J.E., Hildebrand W.H., Ward F.E., Marsh S.G.E., RA Williams R.C., Parham P.; RT "The molecular basis for reactivity of anti-Cw1 and anti-Cw3 RT alloantisera with HLA-B46 haplotypes."; RL Tissue Antigens 39:249-257(1992). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-206 (ALLELE CW*01:02). RX PubMed=7871529; DOI=10.1111/j.1399-0039.1994.tb02394.x; RA Steinle A., Schendel D.J.; RT "HLA class I alleles of LCL 721 and 174 x CEM.T2 (T2)."; RL Tissue Antigens 44:268-270(1994). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*01:03). RC TISSUE=Peripheral blood; RX PubMed=9672159; DOI=10.1111/j.1399-0039.1998.tb02995.x; RA Wang H., Nakajima F., Tokunaga K., Kashiwase K., Ishikawa Y., Juji T.; RT "Cw*0103, a new allele encoding for a novel HLA-Cw1 split in the RT Japanese population."; RL Tissue Antigens 51:571-573(1998). RN [7] RP NUCLEOTIDE SEQUENCE (ALLELE CW*01:04). RA Day S.; RT "Full length sequencing of a new Cw*01 variant allele."; RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases. RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- INTERACTION: CC P43628:KIR2DL3; NbExp=2; IntAct=EBI-13916865, EBI-8632435; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of Cw-1 are known: Cw*01:01 CC (Cw1.1), Cw*01:02 (Cw1.2), Cw*01:03 and Cw*01:04. The sequence CC shown is that of Cw*01:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M26429; AAA59701.1; -; mRNA. DR EMBL; M16272; AAA59700.1; -; Genomic_DNA. DR EMBL; M84171; AAA59685.1; -; mRNA. DR EMBL; Z46809; CAA86839.1; -; mRNA. DR EMBL; D64145; BAA19531.1; -; mRNA. DR EMBL; AJ133100; CAB38942.1; -; Genomic_DNA. DR PIR; I37528; I37528. DR PIR; I54430; I54430. DR PIR; I59622; I59622. DR UniGene; Hs.656020; -. DR UniGene; Hs.743218; -. DR ProteinModelPortal; P30499; -. DR SMR; P30499; -. DR IntAct; P30499; 5. DR iPTMnet; P30499; -. DR SwissPalm; P30499; -. DR DMDM; 231423; -. DR EPD; P30499; -. DR MaxQB; P30499; -. DR PeptideAtlas; P30499; -. DR PRIDE; P30499; -. DR Ensembl; ENST00000438171; ENSP00000393374; ENSG00000237022. DR DisGeNET; 3107; -. DR GeneCards; HLA-C; -. DR HGNC; HGNC:4933; HLA-C. DR HPA; HPA031454; -. DR MalaCards; HLA-C; -. DR MIM; 142840; gene. DR neXtProt; NX_P30499; -. DR HOVERGEN; HBG016709; -. DR PhylomeDB; P30499; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-C; -. DR GO; GO:0009986; C:cell surface; IDA:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; IDA:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; IDA:UniProtKB. DR GO; GO:0046977; F:TAP binding; IDA:UniProtKB. DR GO; GO:0002486; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 366 HLA class I histocompatibility antigen, FT Cw-1 alpha chain. FT /FTId=PRO_0000018868. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 357 357 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 360 360 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 5 5 E -> A (in allele Cw*01:02, allele FT Cw*01:03 and allele Cw*01:04). FT /FTId=VAR_016544. FT VARIANT 43 43 E -> K (in dbSNP:rs1050438). FT /FTId=VAR_056454. FT VARIANT 48 48 S -> A (in dbSNP:rs707911). FT /FTId=VAR_061444. FT VARIANT 48 48 S -> P (in dbSNP:rs707911). FT /FTId=VAR_061445. FT VARIANT 48 48 S -> T (in dbSNP:rs707911). FT /FTId=VAR_061446. FT VARIANT 73 73 A -> E (in dbSNP:rs1050409). FT /FTId=VAR_056455. FT VARIANT 76 76 V -> M (in dbSNP:rs1065382). FT /FTId=VAR_056456. FT VARIANT 90 90 K -> N (in dbSNP:rs28626310). FT /FTId=VAR_056457. FT VARIANT 92 92 N -> K (in allele Cw*01:02, allele FT Cw*01:03 and allele Cw*01:04). FT /FTId=VAR_016545. FT VARIANT 138 138 D -> N (in allele Cw*01:03). FT /FTId=VAR_016546. FT VARIANT 140 140 Y -> F (in allele Cw*01:03). FT /FTId=VAR_016547. FT VARIANT 140 140 Y -> S (in allele Cw*01:04). FT /FTId=VAR_016548. FT VARIANT 179 179 E -> Q (in allele Cw*01:02, allele FT Cw*01:03 and allele Cw*01:04). FT /FTId=VAR_016549. FT VARIANT 180 180 R -> W (in allele Cw*01:04). FT /FTId=VAR_016550. FT VARIANT 201 201 E -> K (in dbSNP:rs1131103). FT /FTId=VAR_056458. FT VARIANT 202 202 S -> T (in allele Cw*01:02, allele FT Cw*01:03 and allele Cw*01:04). FT /FTId=VAR_016551. FT VARIANT 243 243 W -> R (in allele Cw*01:04). FT /FTId=VAR_016552. FT VARIANT 272 272 M -> V (in allele Cw*01:04). FT /FTId=VAR_016553. FT VARIANT 328 328 V -> M (in allele Cw*01:04). FT /FTId=VAR_016554. FT VARIANT 364 364 S -> C (in allele Cw*01:02, allele FT Cw*01:03 and allele Cw*01:04). FT /FTId=VAR_016555. SQ SEQUENCE 366 AA; 40965 MW; 285CCFCB92788744 CRC64; MRVMEPRTLI LLLSGALALT ETWACSHSMK YFFTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YNRQAQTDRV SLRNLRGYYN QSEAGSHTLQ WMCGCDLGPD GRLLRGYDQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEER RAYLEGTCVE WLRRYLENGK ESLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ DTELVETRPA GDGTFQKWAA VMVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIASKA // ID 1C01_PANTR Reviewed; 366 AA. AC P30686; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 28-FEB-2018, entry version 96. DE RecName: Full=Patr class I histocompatibility antigen, C alpha chain; DE AltName: Full=ChLa class I histocompatibility antigen, C alpha chain; DE Flags: Precursor; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1381540; DOI=10.1016/0042-6822(92)90925-F; RA Kato T., Esumi M., Yamashita S., Abe K., Shikata T.; RT "Interferon-inducible gene expression in chimpanzee liver infected RT with hepatitis C virus."; RL Virology 190:856-860(1992). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAA01979.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; D11383; BAA01979.1; ALT_INIT; mRNA. DR UniGene; Ptr.2993; -. DR ProteinModelPortal; P30686; -. DR SMR; P30686; -. DR PRIDE; P30686; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000002277; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 366 Patr class I histocompatibility antigen, FT C alpha chain. FT /FTId=PRO_0000018914. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 357 357 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 360 360 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 192 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 366 AA; 40843 MW; 58B25703B3D82C4D CRC64; MRVTAPRTLL LLLSGGLALT ETWAGSHSLR YFDTAVSRPG RREPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ WMYGCDLGPD GRLLRGYGQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQL RAYLEGKRVE SCRRYLENGK ETLQRTECPK THMTHHPVSD HEATLRCWAL AFYPAEITLT WQRDGEDQIQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PEPLTLRWKP TSQPTIPIVG IVAGLAVLAV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC SNSAQGSDES LIACKA // ID 1C02_GORGO Reviewed; 366 AA. AC P30385; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 28-FEB-2018, entry version 92. DE RecName: Full=Class I histocompatibility antigen, Gogo-C*0201 alpha chain; DE Flags: Precursor; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1744581; DOI=10.1084/jem.174.6.1491; RA Lawlor D.A., Warren E., Taylor P., Parham P.; RT "Gorilla class I major histocompatibility complex alleles: comparison RT to human and chimpanzee class I."; RL J. Exp. Med. 174:1491-1509(1991). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X60251; CAA42803.1; -; mRNA. DR PIR; JH0545; JH0545. DR ProteinModelPortal; P30385; -. DR SMR; P30385; -. DR PRIDE; P30385; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000001519; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 366 Class I histocompatibility antigen, Gogo- FT C*0201 alpha chain. FT /FTId=PRO_0000018906. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 366 AA; 40954 MW; 05E159364C769FC5 CRC64; MRVMAPRTLI LPLSGALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV NLRKLRGYYN QSEDGSHTLQ SMYGCDLGPD GRLLRGYSQF AYDGKDYIAL NEDLRSWTAA DTAAQVTQRK WEAARVAEQE RAYLEGLCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL PEPLTLRWEP SSQPTIPIVG IVVGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC SNSAQGSDES LITCKA // ID 1C02_HUMAN Reviewed; 366 AA. AC P30501; P30502; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 146. DE RecName: Full=HLA class I histocompatibility antigen, Cw-2 alpha chain; DE AltName: Full=MHC class I antigen Cw*2; DE Flags: Precursor; GN Name=HLA-C; Synonyms=HLAC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*02:01). RX PubMed=2708822; RA Ellis S.A., Strachan T., Palmer M.S., McMichael A.J.; RT "Complete nucleotide sequence of a unique HLA class I C locus product RT expressed on the human choriocarcinoma cell line BeWo."; RL J. Immunol. 142:3281-3285(1989). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE CW*02:02). RX PubMed=2715640; RA Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.; RT "Diversity and diversification of HLA-A,B,C alleles."; RL J. Immunol. 142:3937-3950(1989). RN [3] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110. RC TISSUE=Liver; RX PubMed=19159218; DOI=10.1021/pr8008012; RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; RT "Glycoproteomics analysis of human liver tissue by combination of RT multiple enzyme digestion and hydrazide chemistry."; RL J. Proteome Res. 8:651-661(2009). RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [5] RP VARIANT [LARGE SCALE ANALYSIS] 73-GLY-ARG-74 DELINS ALA-PRO, VARIANT RP [LARGE SCALE ANALYSIS] MET-272, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- INTERACTION: CC P43626:KIR2DL1; NbExp=3; IntAct=EBI-9978392, EBI-8684277; CC P43628:KIR2DL3; NbExp=2; IntAct=EBI-9978392, EBI-8632435; CC Q14953:KIR2DS5; NbExp=6; IntAct=EBI-9978392, EBI-16823921; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of Cw-2 are known: Cw*02:01 CC (Cw2.1) and Cw*02:02 (Cw2.2). The sequence shown is that of CC Cw*02:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M26430; AAA59703.1; -; mRNA. DR EMBL; M24030; AAA59671.1; -; Genomic_DNA. DR PIR; I61866; I61866. DR UniGene; Hs.656020; -. DR UniGene; Hs.743218; -. DR ProteinModelPortal; P30501; -. DR SMR; P30501; -. DR IntAct; P30501; 7. DR iPTMnet; P30501; -. DR PhosphoSitePlus; P30501; -. DR SwissPalm; P30501; -. DR EPD; P30501; -. DR MaxQB; P30501; -. DR PeptideAtlas; P30501; -. DR PRIDE; P30501; -. DR Ensembl; ENST00000420206; ENSP00000410214; ENSG00000228299. DR DisGeNET; 3107; -. DR GeneCards; HLA-C; -. DR H-InvDB; HIX0166423; -. DR HGNC; HGNC:4933; HLA-C. DR MalaCards; HLA-C; -. DR MIM; 142840; gene. DR neXtProt; NX_P30501; -. DR HOVERGEN; HBG016709; -. DR PhylomeDB; P30501; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-C; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0046977; F:TAP binding; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 366 HLA class I histocompatibility antigen, FT Cw-2 alpha chain. FT /FTId=PRO_0000018869. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:19159218}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 5 5 E -> A (in allele Cw*02:02). FT /FTId=VAR_016556. FT VARIANT 10 10 I -> L (in allele Cw*02:02). FT /FTId=VAR_016557. FT VARIANT 73 74 GR -> AP (in allele Cw*02:02). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_016558. FT VARIANT 92 92 N -> K (in allele Cw*02:02). FT /FTId=VAR_016559. FT VARIANT 137 137 Y -> H (in dbSNP:rs2308574). FT /FTId=VAR_056459. FT VARIANT 179 179 E -> Q (in allele Cw*02:02). FT /FTId=VAR_016560. FT VARIANT 202 202 K -> T (in allele Cw*02:02). FT /FTId=VAR_016561. FT VARIANT 272 272 V -> M (in dbSNP:rs1050276). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_056460. FT VARIANT 364 364 S -> C (in allele Cw*02:02). FT /FTId=VAR_016562. SQ SEQUENCE 366 AA; 41095 MW; AD8025DEB7DA8CE6 CRC64; MRVMEPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPS RGEPHFIAVG YVDDTQFVRF DSDAASPRGE PRGRWVEQEG PEYWDRETQK YNRQAQTDRV NLRKLRGYYN QSEAGSHTLQ RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEEW RAYLEGECVE WLRRYLENGK EKLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPTEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIASKA // ID 1C03_GORGO Reviewed; 366 AA. AC P30386; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 23-MAY-2018, entry version 89. DE RecName: Full=Class I histocompatibility antigen, Gogo-C*0202 alpha chain; DE Flags: Precursor; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1744581; DOI=10.1084/jem.174.6.1491; RA Lawlor D.A., Warren E., Taylor P., Parham P.; RT "Gorilla class I major histocompatibility complex alleles: comparison RT to human and chimpanzee class I."; RL J. Exp. Med. 174:1491-1509(1991). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X60249; CAA42801.1; -; mRNA. DR PIR; JH0546; JH0546. DR ProteinModelPortal; P30386; -. DR SMR; P30386; -. DR PRIDE; P30386; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000001519; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 366 Class I histocompatibility antigen, Gogo- FT C*0202 alpha chain. FT /FTId=PRO_0000018907. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 366 AA; 40783 MW; 11CCAD1F6091831B CRC64; MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV NLRKLRGYYN QSEDGSHTLQ SMYGCDLGPD GRLLRGYSQF AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQQ RAYLEGLCVE SLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL PEPLTLRWEP SSQPTIPIVG IVVGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC SNSAQGSDES LITCKA // ID 1C03_HUMAN Reviewed; 366 AA. AC P04222; O62883; O78060; O78068; O78069; P30503; Q29743; Q29992; AC Q29993; Q9GIK8; Q9TQB4; DT 20-MAR-1987, integrated into UniProtKB/Swiss-Prot. DT 22-AUG-2003, sequence version 2. DT 12-SEP-2018, entry version 159. DE RecName: Full=HLA class I histocompatibility antigen, Cw-3 alpha chain; DE AltName: Full=MHC class I antigen Cw*3; DE Flags: Precursor; GN Name=HLA-C; Synonyms=HLAC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE CW*03:04). RX PubMed=6609813; RA Sodoyer R., Damotte M., Delovitch T.L., Trucy J., Jordan B.R., RA Strachan T.; RT "Complete nucleotide sequence of a gene encoding a functional human RT class I histocompatibility antigen (HLA-CW3)."; RL EMBO J. 3:879-885(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*03:02). RX PubMed=1384166; DOI=10.1111/j.1399-0039.1992.tb01943.x; RA Zemmour J., Gumperz J.E., Hildebrand W.H., Ward F.E., Marsh S.G.E., RA Williams R.C., Parham P.; RT "The molecular basis for reactivity of anti-Cw1 and anti-Cw3 RT alloantisera with HLA-B46 haplotypes."; RL Tissue Antigens 39:249-257(1992). RN [3] RP NUCLEOTIDE SEQUENCE (ALLELES CW*03:03 AND CW*03:04). RA Domena J.D.; RL Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE (ALLELE CW*03:03). RC TISSUE=Peripheral blood; RA Wang H., Tokunaga K., Kuwata S.; RT "DNA typing of HLA-C locus alleles in Japanese."; RL Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-206 (ALLELE CW*03:04). RX PubMed=8613148; DOI=10.1007/BF02602662; RA Zarling A.L., Smith K.D., Lutz C.T., Lee D.R.; RT "Correction of the HLA-Cw3 genomic sequence tentatively identifies it RT as HLA-Cw*0304."; RL Immunogenetics 44:82-83(1996). RN [6] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE CW*03:07). RX PubMed=11580854; DOI=10.1034/j.1399-0039.2001.580106.x; RA Santos S., Vicario J.L., Garcia-Sanchez F., Aviles M.J., Balas A.; RT "Sequencing based typing for HLA-C. Identification of three new RT alleles: Cw*0307, Cw*0502 and Cw*0504."; RL Tissue Antigens 58:34-37(2001). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES CW*03:05; RP CW*03:06; CW*03:08 AND CW*03:09). RX PubMed=9686604; RA Turner S., Ellexson M.E., Hickman H.D., Sidebottom D.A., RA Fernandez-Vina M., Confer D.L., Hildebrand W.H.; RT "Sequence-based typing provides a new look at HLA-C diversity."; RL J. Immunol. 161:1406-1413(1998). RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE CW*03:13). RX PubMed=11972880; DOI=10.1034/j.1399-0039.2002.590110.x; RA Cox S.T., Ogilvie H., Bohan E.M., Holman R., Prentice H.G., Potter M., RA Madrigal J.A., Little A.-M.; RT "Sequence of two new HLA-Cw alleles: HLA-Cw*0313 and HLA-Cw*1208."; RL Tissue Antigens 59:49-51(2002). RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [10] RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 25-302 IN COMPLEX WITH RP KIR2DL2, AND DISULFIDE BONDS. RX PubMed=10850706; DOI=10.1038/35014520; RA Boyington J.C., Motyka S.A., Schuck P., Brooks A.G., Sun P.D.; RT "Crystal structure of an NK cell immunoglobulin-like receptor in RT complex with its class I MHC ligand."; RL Nature 405:537-543(2000). RN [11] RP VARIANT [LARGE SCALE ANALYSIS] MET-272, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- INTERACTION: CC P43628:KIR2DL3; NbExp=3; IntAct=EBI-13917186, EBI-8632435; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of Cw-3 are known: Cw*03:02 CC (Cw3.2), Cw*03:03, Cw*03:04 (Cw3.1), Cw*03:05, Cw*03:06, Cw*03:07, CC Cw*03:08, Cw*03:09 and Cw*03:13. The sequence shown is that of CC Cw*03:04. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X00495; CAA25190.1; -; Genomic_DNA. DR EMBL; M84172; AAA59686.1; -; mRNA. DR EMBL; M99389; AAA88088.1; -; mRNA. DR EMBL; M99390; AAA88089.1; -; mRNA. DR EMBL; D50853; BAA32610.1; -; mRNA. DR EMBL; U44064; AAB02773.1; -; Genomic_DNA. DR EMBL; AF039198; AAD37816.1; -; Genomic_DNA. DR EMBL; AH006125; AAC17715.1; -; Genomic_DNA. DR EMBL; AH006126; AAC17716.1; -; Genomic_DNA. DR EMBL; AH006127; AAC17717.1; -; Genomic_DNA. DR EMBL; AH006128; AAC17718.1; -; Genomic_DNA. DR EMBL; AJ298116; CAC18746.1; -; Genomic_DNA. DR PIR; A02190; HLHUW3. DR PIR; I81231; I81231. DR UniGene; Hs.656020; -. DR UniGene; Hs.743218; -. DR PDB; 1EFX; X-ray; 3.00 A; A=25-302. DR PDBsum; 1EFX; -. DR ProteinModelPortal; P04222; -. DR SMR; P04222; -. DR IntAct; P04222; 8. DR iPTMnet; P04222; -. DR SwissPalm; P04222; -. DR DMDM; 34223716; -. DR EPD; P04222; -. DR PeptideAtlas; P04222; -. DR PRIDE; P04222; -. DR Ensembl; ENST00000457903; ENSP00000390851; ENSG00000225691. DR DisGeNET; 3107; -. DR GeneCards; HLA-C; -. DR HGNC; HGNC:4933; HLA-C. DR MalaCards; HLA-C; -. DR MIM; 142840; gene. DR neXtProt; NX_P04222; -. DR Orphanet; 99860; Precursor B-cell acute lymphoblastic leukemia. DR HOVERGEN; HBG016709; -. DR PhylomeDB; P04222; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-2172127; DAP12 interactions. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR SIGNOR; P04222; -. DR ChiTaRS; HLA-C; human. DR EvolutionaryTrace; P04222; -. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-C; -. DR GO; GO:0009986; C:cell surface; IDA:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0046977; F:TAP binding; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0045087; P:innate immune response; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 366 HLA class I histocompatibility antigen, FT Cw-3 alpha chain. FT /FTId=PRO_0000018870. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:10850706}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:10850706}. FT VARIANT 73 73 A -> E (in dbSNP:rs1050409). FT /FTId=VAR_056461. FT VARIANT 76 76 V -> M (in dbSNP:rs1065382). FT /FTId=VAR_056462. FT VARIANT 90 90 K -> N (in allele Cw*03:08; FT dbSNP:rs28626310). FT /FTId=VAR_016569. FT VARIANT 101 101 S -> N (in allele Cw*03:07; FT dbSNP:rs2308557). FT /FTId=VAR_016565. FT VARIANT 104 104 N -> K (in allele Cw*03:07; FT dbSNP:rs17408553). FT /FTId=VAR_016566. FT VARIANT 115 115 G -> R (in allele Cw*03:03 and allele FT Cw*03:13; dbSNP:rs1131122). FT /FTId=VAR_016563. FT VARIANT 118 118 I -> T (in allele Cw*03:05 and allele FT Cw*03:13; dbSNP:rs1131119). FT /FTId=VAR_016564. FT VARIANT 119 119 I -> L (in allele Cw*03:02, allele FT Cw*03:05 and allele Cw*03:13; FT dbSNP:rs1071649). FT /FTId=VAR_016567. FT VARIANT 121 121 R -> S (in allele Cw*03:05; FT dbSNP:rs41556316). FT /FTId=VAR_016617. FT VARIANT 127 127 V -> L (in allele Cw*03:09; FT dbSNP:rs34592426). FT /FTId=VAR_016618. FT VARIANT 138 138 D -> V (in allele Cw*03:06; FT dbSNP:rs41542424). FT /FTId=VAR_016619. FT VARIANT 140 140 Y -> S (in allele Cw*03:02; FT dbSNP:rs713032). FT /FTId=VAR_016568. FT VARIANT 272 272 V -> M (in dbSNP:rs1050276). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_056463. FT CONFLICT 33 33 Y -> C (in Ref. 1; CAA25190). FT {ECO:0000305}. FT CONFLICT 64 65 AA -> DE (in Ref. 1; CAA25190). FT {ECO:0000305}. FT CONFLICT 78 79 QE -> RK (in Ref. 1; CAA25190). FT {ECO:0000305}. FT CONFLICT 93 93 R -> P (in Ref. 1; CAA25190). FT {ECO:0000305}. FT CONFLICT 140 140 Y -> H (in Ref. 1; CAA25190). FT {ECO:0000305}. FT CONFLICT 161 161 D -> N (in Ref. 1; CAA25190). FT {ECO:0000305}. FT CONFLICT 205 205 R -> G (in Ref. 1; CAA25190). FT {ECO:0000305}. FT STRAND 28 36 {ECO:0000244|PDB:1EFX}. FT TURN 39 41 {ECO:0000244|PDB:1EFX}. FT STRAND 45 52 {ECO:0000244|PDB:1EFX}. FT STRAND 55 61 {ECO:0000244|PDB:1EFX}. FT STRAND 64 66 {ECO:0000244|PDB:1EFX}. FT STRAND 69 71 {ECO:0000244|PDB:1EFX}. FT HELIX 74 77 {ECO:0000244|PDB:1EFX}. FT HELIX 81 108 {ECO:0000244|PDB:1EFX}. FT STRAND 118 128 {ECO:0000244|PDB:1EFX}. FT STRAND 131 150 {ECO:0000244|PDB:1EFX}. FT STRAND 157 161 {ECO:0000244|PDB:1EFX}. FT HELIX 162 173 {ECO:0000244|PDB:1EFX}. FT HELIX 176 185 {ECO:0000244|PDB:1EFX}. FT HELIX 187 198 {ECO:0000244|PDB:1EFX}. FT HELIX 200 203 {ECO:0000244|PDB:1EFX}. FT STRAND 210 216 {ECO:0000244|PDB:1EFX}. FT STRAND 222 235 {ECO:0000244|PDB:1EFX}. FT STRAND 238 243 {ECO:0000244|PDB:1EFX}. FT TURN 249 251 {ECO:0000244|PDB:1EFX}. FT STRAND 261 263 {ECO:0000244|PDB:1EFX}. FT STRAND 268 274 {ECO:0000244|PDB:1EFX}. FT HELIX 277 280 {ECO:0000244|PDB:1EFX}. FT STRAND 281 286 {ECO:0000244|PDB:1EFX}. FT STRAND 294 296 {ECO:0000244|PDB:1EFX}. SQ SEQUENCE 366 AA; 40861 MW; 47E55680EA1F6D97 CRC64; MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTAVSRPG RGEPHFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEAGSHIIQ RMYGCDVGPD GRLLRGYDQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQL RAYLEGLCVE WLRRYLKNGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA // ID 1C04_GORGO Reviewed; 366 AA. AC P30387; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 23-MAY-2018, entry version 91. DE RecName: Full=Class I histocompatibility antigen, Gogo-C*0203 alpha chain; DE Flags: Precursor; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1744581; DOI=10.1084/jem.174.6.1491; RA Lawlor D.A., Warren E., Taylor P., Parham P.; RT "Gorilla class I major histocompatibility complex alleles: comparison RT to human and chimpanzee class I."; RL J. Exp. Med. 174:1491-1509(1991). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X60248; CAA42800.1; -; mRNA. DR PIR; JH0547; JH0547. DR ProteinModelPortal; P30387; -. DR SMR; P30387; -. DR PRIDE; P30387; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000001519; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 366 Class I histocompatibility antigen, Gogo- FT C*0203 alpha chain. FT /FTId=PRO_0000018908. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 366 AA; 40970 MW; EE962C8189CAC001 CRC64; MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV NLRKLRGYYN QSEDGSHTLQ SMYGCDLGPD GRLLRGYSQF AYDGKDYIAL NEDLRSWTAA DTAAQVTQRK WEAARVAEQE RAYLEGLCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL PEPLTLRWEP SSQPTIPIVG IVVGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC SNSAQGSDES LITCKA // ID 1C04_HUMAN Reviewed; 366 AA. AC P30504; O78067; O78072; O78090; O78149; Q29921; Q9UM42; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 157. DE RecName: Full=HLA class I histocompatibility antigen, Cw-4 alpha chain; DE AltName: Full=MHC class I antigen Cw*4; DE Flags: Precursor; GN Name=HLA-C; Synonyms=HLAC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE CW*04:01). RX PubMed=1317015; DOI=10.1038/357326a0; RA Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J., RA Williams R.C., Luz R., Petzl-Erler M.L., Parham P.; RT "Unusual HLA-B alleles in two tribes of Brazilian Indians."; RL Nature 357:326-329(1992). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*04:01). RX PubMed=1711567; DOI=10.1084/jem.174.1.53; RA Grassi F., Meneveri R., Gullberg M., Lopalco L., Rossi G.B., Lanza P., RA de Santis C., Brattsand G., Butto S., Ginelli E., Beretta A., RA Siccardi A.G.; RT "Human immunodeficiency virus type 1 gp120 mimics a hidden monomorphic RT epitope borne by class I major histocompatibility complex heavy RT chains."; RL J. Exp. Med. 174:53-62(1991). RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE CW*04:01). RC TISSUE=Blood; RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [4] RP NUCLEOTIDE SEQUENCE OF 1-365 (ALLELE CW*04:01). RA Dunn P.P., van Dam M., Crosby I., Carter V.; RT "A sequencing strategy for the rapid sequencing of HLA class I genes RT using random in vitro DNA transposition."; RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE (ALLELE CW*04:03). RC TISSUE=B-cell; RX PubMed=8883300; DOI=10.1111/j.1399-0039.1996.tb02615.x; RA Little A.-M., Mason A., Marsh S.G.E., Parham P.; RT "HLA-C typing of eleven Papua New Guineans: identification of an HLA- RT Cw4/Cw2 hybrid allele."; RL Tissue Antigens 48:113-117(1996). RN [6] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES CW*04:04 AND CW*04:05). RX PubMed=9686604; RA Turner S., Ellexson M.E., Hickman H.D., Sidebottom D.A., RA Fernandez-Vina M., Confer D.L., Hildebrand W.H.; RT "Sequence-based typing provides a new look at HLA-C diversity."; RL J. Immunol. 161:1406-1413(1998). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE CW*04:06). RX PubMed=10090622; DOI=10.1034/j.1399-0039.1999.530212.x; RA Ren E.C., Haniff F., Loh M.T., Chan S.H., Petersdorf E., Hansen J.; RT "Identification of a novel HLA-C allele, Cw*0406, in a Singapore RT Malay."; RL Tissue Antigens 53:198-200(1999). RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE CW*04:06). RX PubMed=10395115; DOI=10.1034/j.1399-0039.1999.530615.x; RA Carbonnelle E., Poirier J.C., Fortier C., Marzais F., Visser C.J.T., RA Borie C., Toubert A., Raffoux C., Charron D., Tamouza R.; RT "Characterization of a novel HLA-Cw*04 variant in a Laotian family: RT HLA-Cw*0406."; RL Tissue Antigens 53:601-603(1999). RN [9] RP INTERACTION WITH HTLV-1 ACCESSORY PROTEIN P12I (MICROBIAL INFECTION). RX PubMed=11390610; DOI=10.1128/JVI.75.13.6086-6094.2001; RA Johnson J.M., Nicot C., Fullen J., Ciminale V., Casareto L., RA Mulloy J.C., Jacobson S., Franchini G.; RT "Free major histocompatibility complex class I heavy chain is RT preferentially targeted for degradation by human T-cell RT leukemia/lymphotropic virus type 1 p12(I) protein."; RL J. Virol. 75:6086-6094(2001). RN [10] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [11] RP VARIANT [LARGE SCALE ANALYSIS] ALA-73, VARIANT [LARGE SCALE ANALYSIS] RP MET-272, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBUNIT: (Microbial infection) Interacts with HTLV-1 p12I CC accessory protein. {ECO:0000269|PubMed:11390610}. CC -!- INTERACTION: CC P43626:KIR2DL1; NbExp=3; IntAct=EBI-1051396, EBI-8684277; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of Cw-4 are known: Cw*04:01 CC Cw*04:03, Cw*04:04, Cw*04:05 and Cw*04:06. The sequence shown is CC that of Cw*04:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M84386; AAA59705.1; -; mRNA. DR EMBL; X58536; CAA41427.1; -; mRNA. DR EMBL; AJ278494; CAB95011.1; -; Genomic_DNA. DR EMBL; AJ238694; CAB41889.2; -; Genomic_DNA. DR EMBL; L54059; AAB04639.1; -; Genomic_DNA. DR EMBL; AH006129; AAC17719.1; -; Genomic_DNA. DR EMBL; AH006130; AAC17720.1; -; Genomic_DNA. DR EMBL; AF076476; AAC27626.1; -; Genomic_DNA. DR EMBL; AH006107; AAC16245.1; -; Genomic_DNA. DR PIR; A59028; A59028. DR PIR; JH0526; JH0526. DR UniGene; Hs.656020; -. DR UniGene; Hs.743218; -. DR PDB; 1IM9; X-ray; 2.80 A; A/E=25-299. DR PDB; 1QQD; X-ray; 2.70 A; A=26-298. DR PDBsum; 1IM9; -. DR PDBsum; 1QQD; -. DR ProteinModelPortal; P30504; -. DR SMR; P30504; -. DR DIP; DIP-40945N; -. DR IntAct; P30504; 19. DR MINT; P30504; -. DR SwissPalm; P30504; -. DR DMDM; 231433; -. DR EPD; P30504; -. DR MaxQB; P30504; -. DR PeptideAtlas; P30504; -. DR PRIDE; P30504; -. DR Ensembl; ENST00000400341; ENSP00000383195; ENSG00000206435. DR Ensembl; ENST00000400394; ENSP00000383244; ENSG00000206452. DR DisGeNET; 3107; -. DR GeneCards; HLA-C; -. DR HGNC; HGNC:4933; HLA-C. DR MalaCards; HLA-C; -. DR MIM; 142840; gene. DR neXtProt; NX_P30504; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-2172127; DAP12 interactions. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-C; human. DR EvolutionaryTrace; P30504; -. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-C; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0046977; F:TAP binding; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0045087; P:innate immune response; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR GO; GO:0016032; P:viral process; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Host-virus interaction; Immunity; Membrane; MHC I; Polymorphism; KW Reference proteome; Signal; Transmembrane; Transmembrane helix; KW Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 366 HLA class I histocompatibility antigen, FT Cw-4 alpha chain. FT /FTId=PRO_0000018871. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 33 33 S -> Y (in allele Cw*04:03 and allele FT Cw*04:06). FT /FTId=VAR_016571. FT VARIANT 35 35 S -> A (in allele Cw*04:03 and allele FT Cw*04:06). FT /FTId=VAR_016572. FT VARIANT 38 38 W -> R (in allele Cw*04:03 and allele FT Cw*04:06). FT /FTId=VAR_016573. FT VARIANT 40 40 G -> S (in allele Cw*04:03 and allele FT Cw*04:06). FT /FTId=VAR_016574. FT VARIANT 45 45 R -> H (in allele Cw*04:03 and allele FT Cw*04:06). FT /FTId=VAR_016575. FT VARIANT 52 52 V -> L (in allele Cw*04:05). FT /FTId=VAR_016576. FT VARIANT 73 73 E -> A (in allele Cw*04:03 and allele FT Cw*04:06). {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_016577. FT VARIANT 76 76 V -> M (in dbSNP:rs1065382). FT /FTId=VAR_056464. FT VARIANT 90 90 K -> N (in dbSNP:rs28626310). FT /FTId=VAR_056465. FT VARIANT 97 97 A -> T (in dbSNP:rs41543814). FT /FTId=VAR_056466. FT VARIANT 180 180 R -> L (in allele Cw*04:04 and allele FT Cw*04:06). FT /FTId=VAR_016578. FT VARIANT 201 201 E -> K (in dbSNP:rs1131103). FT /FTId=VAR_056468. FT VARIANT 272 272 V -> M (in dbSNP:rs1050276). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_056469. FT VARIANT 327 327 M -> V (in allele Cw*04:03 and allele FT Cw*04:06). FT /FTId=VAR_016579. FT STRAND 27 37 {ECO:0000244|PDB:1QQD}. FT STRAND 45 52 {ECO:0000244|PDB:1QQD}. FT STRAND 55 66 {ECO:0000244|PDB:1QQD}. FT STRAND 70 73 {ECO:0000244|PDB:1QQD}. FT HELIX 74 77 {ECO:0000244|PDB:1QQD}. FT HELIX 81 108 {ECO:0000244|PDB:1QQD}. FT STRAND 113 115 {ECO:0000244|PDB:1QQD}. FT STRAND 117 127 {ECO:0000244|PDB:1QQD}. FT STRAND 129 142 {ECO:0000244|PDB:1QQD}. FT STRAND 145 150 {ECO:0000244|PDB:1QQD}. FT STRAND 157 161 {ECO:0000244|PDB:1QQD}. FT HELIX 162 173 {ECO:0000244|PDB:1QQD}. FT HELIX 176 185 {ECO:0000244|PDB:1QQD}. FT HELIX 187 198 {ECO:0000244|PDB:1QQD}. FT HELIX 200 203 {ECO:0000244|PDB:1QQD}. FT STRAND 210 217 {ECO:0000244|PDB:1QQD}. FT STRAND 219 221 {ECO:0000244|PDB:1QQD}. FT STRAND 223 235 {ECO:0000244|PDB:1QQD}. FT STRAND 238 243 {ECO:0000244|PDB:1QQD}. FT HELIX 249 251 {ECO:0000244|PDB:1QQD}. FT STRAND 252 254 {ECO:0000244|PDB:1IM9}. FT STRAND 261 263 {ECO:0000244|PDB:1QQD}. FT STRAND 265 273 {ECO:0000244|PDB:1QQD}. FT HELIX 278 280 {ECO:0000244|PDB:1QQD}. FT STRAND 281 286 {ECO:0000244|PDB:1QQD}. FT STRAND 290 292 {ECO:0000244|PDB:1IM9}. FT STRAND 294 296 {ECO:0000244|PDB:1QQD}. SQ SEQUENCE 366 AA; 40995 MW; E883EB3968658DCB CRC64; MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFSTSVSWPG RGEPRFIAVG YVDDTQFVRF DSDAASPRGE PREPWVEQEG PEYWDRETQK YKRQAQADRV NLRKLRGYYN QSEDGSHTLQ RMFGCDLGPD GRLLRGYNQF AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQR RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWKP SSQPTIPIVG IVAGLAVLAV LAVLGAMVAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA // ID 1C05_HUMAN Reviewed; 366 AA. AC Q9TNN7; O02866; O62888; Q9TPV8; Q9TPX2; DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 12-SEP-2018, entry version 135. DE RecName: Full=HLA class I histocompatibility antigen, Cw-5 alpha chain; DE AltName: Full=MHC class I antigen Cw*5; DE Flags: Precursor; GN Name=HLA-C; Synonyms=HLAC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE CW*05:01). RA Baurain J.-F., Coulie P.G.; RT "New HLA-C alleles, on the basis of their transmembrane or cytoplasmic RT regions."; RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE CW*05:01). RA Ellexson M.E., Zhang W., Hildebrand W.H.; RT "Cw*0501new."; RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE OF 1-298 (ALLELE CW*05:01). RC TISSUE=Peripheral blood; RA Wang H., Tokunaga K.; RT "HLA-C locus polymorphisms in Japanese."; RL Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE CW*05:02). RA Santos S., Vicario J.L., Balas A.; RT "Novel HLA-C allele."; RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*05:03). RX PubMed=10885573; DOI=10.1034/j.1399-0039.2000.550515.x; RA Huang L.Q., Boon T., Van Pel A.; RT "Identification of a novel HLA-Cw*05 allele, Cw*0503."; RL Tissue Antigens 55:473-474(2000). RN [6] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE CW*05:04). RA Santos S., Balas A., Vicario J.L.; RT "New HLA-Cw5 antigen."; RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases. RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [8] RP VARIANT [LARGE SCALE ANALYSIS] MET-272, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- INTERACTION: CC P43626:KIR2DL1; NbExp=3; IntAct=EBI-13916949, EBI-8684277; CC Q14953:KIR2DS5; NbExp=6; IntAct=EBI-13916949, EBI-16823921; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of Cw-5 are known: Cw*05:01 CC Cw*0502, Cw*05:03 and Cw*05:04. The sequence shown is that of CC Cw*05:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AJ010748; CAA09340.1; -; mRNA. DR EMBL; U57028; AAD11469.1; -; mRNA. DR EMBL; D64148; BAA19534.1; -; mRNA. DR EMBL; AH005907; AAC05205.2; -; Genomic_DNA. DR EMBL; AF168611; AAD50823.1; -; mRNA. DR EMBL; AH008115; AAD51331.1; -; Genomic_DNA. DR PIR; A59028; A59028. DR UniGene; Hs.654404; -. DR UniGene; Hs.656020; -. DR UniGene; Hs.726974; -. DR UniGene; Hs.743218; -. DR UniGene; Hs.77961; -. DR PDB; 5VGD; X-ray; 2.32 A; A=26-302. DR PDBsum; 5VGD; -. DR ProteinModelPortal; Q9TNN7; -. DR SMR; Q9TNN7; -. DR IntAct; Q9TNN7; 6. DR iPTMnet; Q9TNN7; -. DR SwissPalm; Q9TNN7; -. DR DMDM; 34305707; -. DR EPD; Q9TNN7; -. DR MaxQB; Q9TNN7; -. DR PeptideAtlas; Q9TNN7; -. DR PRIDE; Q9TNN7; -. DR Ensembl; ENST00000400341; ENSP00000383195; ENSG00000206435. DR Ensembl; ENST00000400394; ENSP00000383244; ENSG00000206452. DR UCSC; uc063yse.1; human. DR DisGeNET; 3107; -. DR GeneCards; HLA-C; -. DR HGNC; HGNC:4933; HLA-C. DR MalaCards; HLA-C; -. DR MIM; 142840; gene. DR neXtProt; NX_Q9TNN7; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-C; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0016020; C:membrane; HDA:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 366 HLA class I histocompatibility antigen, FT Cw-5 alpha chain. FT /FTId=PRO_0000018872. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 73 73 A -> E (in dbSNP:rs1050409). FT /FTId=VAR_056470. FT VARIANT 76 76 V -> M (in dbSNP:rs1065382). FT /FTId=VAR_056471. FT VARIANT 90 90 K -> N (in dbSNP:rs28626310). FT /FTId=VAR_056472. FT VARIANT 138 138 N -> D (in allele Cw*05:04; FT dbSNP:rs2308575). FT /FTId=VAR_016580. FT VARIANT 140 140 F -> S (in allele Cw*05:04; FT dbSNP:rs713032). FT /FTId=VAR_016581. FT VARIANT 201 201 K -> E (in allele Cw*0502; FT dbSNP:rs1131103). FT /FTId=VAR_016582. FT VARIANT 207 208 EH -> DP (in allele Cw*05:03). FT /FTId=VAR_016583. FT VARIANT 218 218 V -> I (in allele Cw*05:03; FT dbSNP:rs1050716). FT /FTId=VAR_016584. FT VARIANT 223 223 A -> V (in allele Cw*05:03; FT dbSNP:rs41545014). FT /FTId=VAR_016585. FT VARIANT 272 272 V -> M (in dbSNP:rs1050276). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_056473. FT STRAND 28 36 {ECO:0000244|PDB:5VGD}. FT STRAND 39 42 {ECO:0000244|PDB:5VGD}. FT STRAND 45 52 {ECO:0000244|PDB:5VGD}. FT STRAND 55 62 {ECO:0000244|PDB:5VGD}. FT STRAND 64 66 {ECO:0000244|PDB:5VGD}. FT HELIX 74 76 {ECO:0000244|PDB:5VGD}. FT STRAND 77 79 {ECO:0000244|PDB:5VGD}. FT HELIX 81 108 {ECO:0000244|PDB:5VGD}. FT STRAND 113 115 {ECO:0000244|PDB:5VGD}. FT STRAND 118 127 {ECO:0000244|PDB:5VGD}. FT STRAND 129 142 {ECO:0000244|PDB:5VGD}. FT STRAND 145 150 {ECO:0000244|PDB:5VGD}. FT STRAND 157 159 {ECO:0000244|PDB:5VGD}. FT HELIX 162 174 {ECO:0000244|PDB:5VGD}. FT HELIX 176 185 {ECO:0000244|PDB:5VGD}. FT HELIX 187 198 {ECO:0000244|PDB:5VGD}. FT TURN 199 204 {ECO:0000244|PDB:5VGD}. FT STRAND 212 217 {ECO:0000244|PDB:5VGD}. FT STRAND 219 235 {ECO:0000244|PDB:5VGD}. FT STRAND 239 243 {ECO:0000244|PDB:5VGD}. FT TURN 249 251 {ECO:0000244|PDB:5VGD}. FT STRAND 261 263 {ECO:0000244|PDB:5VGD}. FT STRAND 265 274 {ECO:0000244|PDB:5VGD}. FT HELIX 278 280 {ECO:0000244|PDB:5VGD}. FT STRAND 281 285 {ECO:0000244|PDB:5VGD}. FT STRAND 294 296 {ECO:0000244|PDB:5VGD}. SQ SEQUENCE 366 AA; 40912 MW; 26454A7EE68151DA CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVQF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV NLRKLRGYYN QSEAGSHTLQ RMYGCDLGPD GRLLRGYNQF AYDGKDYIAL NEDLRSWTAA DKAAQITQRK WEAAREAEQR RAYLEGTCVE WLRRYLENGK KTLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWGP SSQPTIPIVG IVAGLAVLAV LAVLGAVMAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA // ID 1C06_HUMAN Reviewed; 366 AA. AC Q29963; O19505; O78063; Q29989; DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 22-AUG-2003, sequence version 2. DT 12-SEP-2018, entry version 151. DE RecName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain; DE AltName: Full=MHC class I antigen Cw*6; DE Flags: Precursor; GN Name=HLA-C; Synonyms=HLAC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*06:02). RX PubMed=2714853; DOI=10.1007/BF00352842; RA Mizuno S., Kang S.H., Lee H.W., Trapani J.A., Dupont B., Yang S.Y.; RT "Isolation and expression of a cDNA clone encoding HLA-CW6: unique RT characteristics of HLA-C encoded gene products."; RL Immunogenetics 29:323-330(1989). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE CW*06:02). RX PubMed=1598685; DOI=10.1111/j.1399-0039.1992.tb01923.x; RA Steinle A., Noessner E., Schendel D.J.; RT "Isolation and characterization of a genomic HLA-Cw6 clone."; RL Tissue Antigens 39:134-137(1992). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] OF 22-366 (ALLELE CW*06:02). RX PubMed=2714852; DOI=10.1007/BF00352839; RA Pohla H., Kuon W., Tabaczewski P., Doerner C., Weiss E.H.; RT "Allelic variation in HLA-B and HLA-C sequences and the evolution of RT the HLA-B alleles."; RL Immunogenetics 29:297-307(1989). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE CW*06:03). RX PubMed=9686604; RA Turner S., Ellexson M.E., Hickman H.D., Sidebottom D.A., RA Fernandez-Vina M., Confer D.L., Hildebrand W.H.; RT "Sequence-based typing provides a new look at HLA-C diversity."; RL J. Immunol. 161:1406-1413(1998). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE CW*06:04). RC TISSUE=Blood; RX PubMed=10395103; DOI=10.1034/j.1399-0039.1999.530603.x; RA Inoue T., Ogawa A., Tokunaga K., Ishikawa Y., Kashiwase K., Tanaka H., RA Park M.H., Jia G.J., Chimge N.-O., Sideltseva E.W., Akaza T., RA Tadokoro K., Takahashi T., Juji T.; RT "Diversity of HLA-B17 alleles and haplotypes in East Asians and a RT novel Cw6 allele (Cw*0604) associated with B*5701."; RL Tissue Antigens 53:534-544(1999). RN [6] RP ASSOCIATION OF ALLELE CW*06:02 WITH PSORIASIS. RX PubMed=11122018; DOI=10.1046/j.1365-2133.2000.03885.x; RA Mallon E., Bunce M., Savoie H., Rowe A., Newson R., Gotch F., RA Bunker C.B.; RT "HLA-C and guttate psoriasis."; RL Br. J. Dermatol. 143:1177-1182(2000). RN [7] RP ASSOCIATION OF ALLELE CW*06:02 WITH PSORIASIS. RX PubMed=16235096; DOI=10.1007/s00439-005-0048-2; RA Helms C., Saccone N.L., Cao L., Daw J.A.W., Cao K., Hsu T.M., RA Taillon-Miller P., Duan S., Gordon D., Pierce B., Ott J., Rice J., RA Fernandez-Vina M.A., Kwok P.-Y., Menter A., Bowcock A.M.; RT "Localization of PSORS1 to a haplotype block harboring HLA-C and RT distinct from corneodesmosin and HCR."; RL Hum. Genet. 118:466-476(2005). RN [8] RP INVOLVEMENT IN PSORS1. RX PubMed=16642438; DOI=10.1086/503821; RA Nair R.P., Stuart P.E., Nistor I., Hiremagalore R., Chia N.V.C., RA Jenisch S., Weichenthal M., Abecasis G.R., Lim H.W., Christophers E., RA Voorhees J.J., Elder J.T.; RT "Sequence and haplotype analysis supports HLA-C as the psoriasis RT susceptibility 1 gene."; RL Am. J. Hum. Genet. 78:827-851(2006). RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [10] RP VARIANT [LARGE SCALE ANALYSIS] MET-272, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- INTERACTION: CC P43626:KIR2DL1; NbExp=3; IntAct=EBI-4400689, EBI-8684277; CC Q14954:KIR2DS1; NbExp=4; IntAct=EBI-4400689, EBI-2865976; CC Q14953:KIR2DS5; NbExp=6; IntAct=EBI-4400689, EBI-16823921; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of Cw-6 are known: Cw*06:02 CC Cw*06:03 and Cw*06:04. Allele Cw*062 is a risk factor that confers CC susceptibility to psoriasis. The sequence shown is that of CC Cw*06:02. CC -!- DISEASE: Psoriasis 1 (PSORS1) [MIM:177900]: A common, chronic CC inflammatory disease of the skin with multifactorial etiology. It CC is characterized by red, scaly plaques usually found on the scalp, CC elbows and knees. These lesions are caused by abnormal CC keratinocyte proliferation and infiltration of inflammatory cells CC into the dermis and epidermis. {ECO:0000269|PubMed:16642438}. CC Note=Disease susceptibility is associated with variations CC affecting the gene represented in this entry. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M28160; AAA36235.1; -; mRNA. DR EMBL; Z22752; CAA80437.1; -; Genomic_DNA. DR EMBL; Z22753; CAA80437.1; JOINED; Genomic_DNA. DR EMBL; Z22754; CAA80437.1; JOINED; Genomic_DNA. DR EMBL; M28206; AAA57258.1; -; mRNA. DR EMBL; AF019568; AAC17721.1; -; Genomic_DNA. DR EMBL; AF019567; AAC17721.1; JOINED; Genomic_DNA. DR EMBL; AB008136; BAA22919.1; -; Genomic_DNA. DR PIR; I68749; I68749. DR UniGene; Hs.656020; -. DR UniGene; Hs.743218; -. DR PDB; 5W67; X-ray; 2.30 A; A=25-300. DR PDB; 5W69; X-ray; 2.80 A; A/C/E/G=25-300. DR PDB; 5W6A; X-ray; 1.74 A; A/C=25-300. DR PDBsum; 5W67; -. DR PDBsum; 5W69; -. DR PDBsum; 5W6A; -. DR ProteinModelPortal; Q29963; -. DR SMR; Q29963; -. DR IntAct; Q29963; 8. DR SwissPalm; Q29963; -. DR DMDM; 34305706; -. DR EPD; Q29963; -. DR PeptideAtlas; Q29963; -. DR PRIDE; Q29963; -. DR Ensembl; ENST00000420206; ENSP00000410214; ENSG00000228299. DR DisGeNET; 3107; -. DR GeneCards; HLA-C; -. DR HGNC; HGNC:4933; HLA-C. DR HPA; HPA031454; -. DR MalaCards; HLA-C; -. DR MIM; 142840; gene. DR MIM; 177900; phenotype. DR neXtProt; NX_Q29963; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-C; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 366 HLA class I histocompatibility antigen, FT Cw-6 alpha chain. FT /FTId=PRO_0000018873. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 33 33 D -> Y (in allele Cw*06:03; FT dbSNP:rs9264668). FT /FTId=VAR_016620. FT VARIANT 43 43 E -> K (in dbSNP:rs1050438). FT /FTId=VAR_056474. FT VARIANT 48 48 S -> A (in dbSNP:rs707911). FT /FTId=VAR_061447. FT VARIANT 48 48 S -> P (in dbSNP:rs707911). FT /FTId=VAR_061448. FT VARIANT 48 48 S -> T (in dbSNP:rs707911). FT /FTId=VAR_061449. FT VARIANT 73 73 A -> E (in dbSNP:rs1050409). FT /FTId=VAR_056475. FT VARIANT 76 76 V -> M (in dbSNP:rs1065382). FT /FTId=VAR_056476. FT VARIANT 90 90 K -> N (in dbSNP:rs28626310). FT /FTId=VAR_056477. FT VARIANT 97 97 A -> T (in dbSNP:rs41543814). FT /FTId=VAR_056478. FT VARIANT 137 137 Y -> H (in dbSNP:rs2308574). FT /FTId=VAR_056479. FT VARIANT 180 180 W -> L (in allele Cw*06:04; FT dbSNP:rs796925732). FT /FTId=VAR_016621. FT VARIANT 201 201 E -> K (in dbSNP:rs1131103). FT /FTId=VAR_056481. FT VARIANT 272 272 V -> M (in dbSNP:rs1050276). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_056482. FT CONFLICT 33 33 D -> C (in Ref. 3; AAA57258). FT {ECO:0000305}. FT CONFLICT 202 202 T -> S (in Ref. 1; AAA36235). FT {ECO:0000305}. FT STRAND 28 36 {ECO:0000244|PDB:5W6A}. FT STRAND 41 43 {ECO:0000244|PDB:5W6A}. FT STRAND 45 52 {ECO:0000244|PDB:5W6A}. FT STRAND 55 61 {ECO:0000244|PDB:5W6A}. FT STRAND 64 66 {ECO:0000244|PDB:5W6A}. FT HELIX 74 77 {ECO:0000244|PDB:5W6A}. FT HELIX 81 109 {ECO:0000244|PDB:5W6A}. FT STRAND 118 127 {ECO:0000244|PDB:5W6A}. FT STRAND 131 142 {ECO:0000244|PDB:5W6A}. FT STRAND 145 150 {ECO:0000244|PDB:5W6A}. FT STRAND 157 159 {ECO:0000244|PDB:5W6A}. FT HELIX 162 173 {ECO:0000244|PDB:5W6A}. FT HELIX 176 185 {ECO:0000244|PDB:5W6A}. FT HELIX 187 198 {ECO:0000244|PDB:5W6A}. FT HELIX 200 203 {ECO:0000244|PDB:5W6A}. FT STRAND 210 219 {ECO:0000244|PDB:5W6A}. FT STRAND 222 235 {ECO:0000244|PDB:5W6A}. FT STRAND 238 243 {ECO:0000244|PDB:5W6A}. FT HELIX 249 251 {ECO:0000244|PDB:5W6A}. FT STRAND 252 254 {ECO:0000244|PDB:5W67}. FT STRAND 261 263 {ECO:0000244|PDB:5W6A}. FT STRAND 265 274 {ECO:0000244|PDB:5W6A}. FT HELIX 278 280 {ECO:0000244|PDB:5W6A}. FT STRAND 281 286 {ECO:0000244|PDB:5W6A}. FT STRAND 294 296 {ECO:0000244|PDB:5W6A}. SQ SEQUENCE 366 AA; 40969 MW; 45876CB22256DE80 CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV NLRKLRGYYN QSEDGSHTLQ WMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQW RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVMAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA // ID 1C07_HUMAN Reviewed; 366 AA. AC P10321; O78061; O78083; Q29631; Q29652; Q29867; Q29990; Q95463; AC Q95603; Q9MY31; Q9TQP9; DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot. DT 20-DEC-2005, sequence version 3. DT 12-SEP-2018, entry version 177. DE RecName: Full=HLA class I histocompatibility antigen, Cw-7 alpha chain; DE AltName: Full=MHC class I antigen Cw*7; DE Flags: Precursor; GN Name=HLA-C; Synonyms=HLAC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*07:04). RX PubMed=7482492; DOI=10.1111/j.1399-0039.1995.tb02471.x; RA Vilches C., Bunce M., de Pablo R., Herrero M.J., Kreisler M.; RT "Anchored PCR cloning of the novel HLA-Cw*0704 allele detected by PCR- RT SSP."; RL Tissue Antigens 46:19-23(1995). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES CW*07:02 AND CW*07:04). RC TISSUE=Blood; RX PubMed=8655361; DOI=10.1016/0198-8859(95)00150-6; RA Wang H., Tokunaga K., Ishikawa Y., Asahina A., Kuwata S., Akaza T., RA Tadokoro K., Shibata Y., Takiguchi M., Juji T.; RT "Identification and DNA typing of two Cw7 alleles (Cw*0702 and RT Cw*0704) in Japanese, with the corrected sequence of Cw*0702."; RL Hum. Immunol. 45:52-58(1996). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*07:06). RX PubMed=9008313; DOI=10.1111/j.1399-0039.1996.tb02694.x; RA Vilches C., Bunce M., Sanz L., de Pablo R., Puente S., Kreisler M.; RT "Molecular cloning of two new HLA-C alleles: Cw*1801 and Cw*0706."; RL Tissue Antigens 48:698-702(1996). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE CW*07:02). RX PubMed=9435339; DOI=10.1007/s002510050350; RA Cooper S.L., Adams E.J., Wells R.S., Walker C.M., Parham P.; RT "A major histocompatibility complex class I allele shared by two RT species of chimpanzee."; RL Immunogenetics 47:212-217(1998). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*07:11). RX PubMed=10372547; DOI=10.1034/j.1399-0039.1999.530508.x; RA Baurain J.-F., Coulie P.G.; RT "Correction of HLA-Cw*0501 and identification of HLA-Cw*0711."; RL Tissue Antigens 53:510-512(1999). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES CW*07:02 AND CW*07:04). RC TISSUE=Blood; RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [7] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*07:04). RC TISSUE=Melanoma; RA Coulie P.G.; RT "Identification of a new HLA-Cw7 allele."; RL Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [9] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-206 (ALLELE CW*07:01). RX PubMed=7871529; DOI=10.1111/j.1399-0039.1994.tb02394.x; RA Steinle A., Schendel D.J.; RT "HLA class I alleles of LCL 721 and 174 x CEM.T2 (T2)."; RL Tissue Antigens 44:268-270(1994). RN [10] RP NUCLEOTIDE SEQUENCE [MRNA] OF 25-366 (ALLELE CW*07:03). RX PubMed=3863816; RA Davidson W.F., Kress M., Khoury G., Jay G.; RT "Comparison of HLA class I gene sequences. Derivation of locus- RT specific oligonucleotide probes specific for HLA-A, HLA-B, and HLA-C RT genes."; RL J. Biol. Chem. 260:13414-13423(1985). RN [11] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE CW*07:09). RX PubMed=9686604; RA Turner S., Ellexson M.E., Hickman H.D., Sidebottom D.A., RA Fernandez-Vina M., Confer D.L., Hildebrand W.H.; RT "Sequence-based typing provides a new look at HLA-C diversity."; RL J. Immunol. 161:1406-1413(1998). RN [12] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-338 (ALLELE CW*07:01). RX PubMed=10488744; DOI=10.1034/j.1399-0039.1999.540208.x; RA van der Vlies S.A., Voorter C.E., van den Berg-Loonen E.M.; RT "There is more to HLA -C than exons 2 and 3: sequencing exons 1, 4 and RT 5."; RL Tissue Antigens 54:169-177(1999). RN [13] RP NUCLEOTIDE SEQUENCE [MRNA] OF 77-309 (ALLELE CW*07:01). RX PubMed=2714852; DOI=10.1007/BF00352839; RA Pohla H., Kuon W., Tabaczewski P., Doerner C., Weiss E.H.; RT "Allelic variation in HLA-B and HLA-C sequences and the evolution of RT the HLA-B alleles."; RL Immunogenetics 29:297-307(1989). RN [14] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [15] RP VARIANT [LARGE SCALE ANALYSIS] SER-350, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- INTERACTION: CC P43628:KIR2DL3; NbExp=2; IntAct=EBI-9978491, EBI-8632435; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of Cw-7 are known: Cw*07:01, CC Cw*07:02, Cw*07:03, Cw*07:04, Cw*07:06, Cw*07:09 and Cw*07:11. The CC sequence shown is that of Cw*07:02. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X83394; CAA58313.1; -; mRNA. DR EMBL; D38526; BAA07531.1; -; mRNA. DR EMBL; D49819; BAA08625.1; -; mRNA. DR EMBL; D49552; BAA08500.1; -; mRNA. DR EMBL; X97321; CAA65986.1; -; mRNA. DR EMBL; AJ001977; CAA05125.1; ALT_SEQ; Genomic_DNA. DR EMBL; AJ010749; CAA09341.1; -; mRNA. DR EMBL; AJ293016; CAC04321.1; -; Genomic_DNA. DR EMBL; AJ293017; CAC04322.1; -; Genomic_DNA. DR EMBL; AJ291815; CAC19191.1; -; Genomic_DNA. DR EMBL; U09853; AAA50217.1; -; mRNA. DR EMBL; AL671883; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; Z46810; CAA86840.1; -; mRNA. DR EMBL; M11886; AAA52665.1; -; mRNA. DR EMBL; AH006132; AAC17722.1; -; Genomic_DNA. DR EMBL; Y18533; CAB71800.1; -; Genomic_DNA. DR EMBL; Y18534; CAB71800.1; JOINED; Genomic_DNA. DR EMBL; Y18535; CAB71800.1; JOINED; Genomic_DNA. DR EMBL; Y18536; CAB71800.1; JOINED; Genomic_DNA. DR EMBL; M28207; AAA53259.1; -; mRNA. DR CCDS; CCDS34393.1; -. DR PIR; A24512; HLHUC4. DR PIR; I37078; I37078. DR PIR; I37529; I37529. DR PIR; I68750; I68750. DR RefSeq; NP_002108.4; NM_002117.5. DR UniGene; Hs.656020; -. DR UniGene; Hs.743218; -. DR PDB; 3BZF; X-ray; 2.50 A; P/Q=3-11. DR PDB; 5VGE; X-ray; 2.60 A; A=26-300. DR PDBsum; 3BZF; -. DR PDBsum; 5VGE; -. DR ProteinModelPortal; P10321; -. DR SMR; P10321; -. DR BioGrid; 109352; 112. DR IntAct; P10321; 10. DR STRING; 9606.ENSP00000365402; -. DR iPTMnet; P10321; -. DR SwissPalm; P10321; -. DR BioMuta; TET2; -. DR DMDM; 84028168; -. DR EPD; P10321; -. DR PaxDb; P10321; -. DR PeptideAtlas; P10321; -. DR PRIDE; P10321; -. DR DNASU; 3107; -. DR Ensembl; ENST00000376228; ENSP00000365402; ENSG00000204525. DR GeneID; 3107; -. DR KEGG; hsa:3107; -. DR CTD; 3107; -. DR DisGeNET; 3107; -. DR EuPathDB; HostDB:ENSG00000204525.15; -. DR GeneCards; HLA-C; -. DR HGNC; HGNC:4933; HLA-C. DR MalaCards; HLA-C; -. DR MIM; 142840; gene. DR neXtProt; NX_P10321; -. DR OpenTargets; ENSG00000204525; -. DR PharmGKB; PA35057; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR PhylomeDB; P10321; -. DR TreeFam; TF336617; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-6798695; Neutrophil degranulation. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-C; human. DR EvolutionaryTrace; P10321; -. DR GeneWiki; HLA-C; -. DR GenomeRNAi; 3107; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204525; Expressed in 234 organ(s), highest expression level in mononuclear cell. DR CleanEx; HS_HLA-C; -. DR ExpressionAtlas; P10321; baseline and differential. DR Genevisible; P10321; HS. DR GO; GO:0009986; C:cell surface; IDA:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030667; C:secretory granule membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 366 HLA class I histocompatibility antigen, FT Cw-7 alpha chain. FT /FTId=PRO_0000018874. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 10 10 L -> I (in dbSNP:rs2308527). FT /FTId=VAR_059506. FT VARIANT 43 43 E -> K (in dbSNP:rs1050438). FT /FTId=VAR_050345. FT VARIANT 48 48 S -> A (in dbSNP:rs707911). FT /FTId=VAR_061450. FT VARIANT 48 48 S -> P (in dbSNP:rs707911). FT /FTId=VAR_061451. FT VARIANT 48 48 S -> T (in dbSNP:rs707911). FT /FTId=VAR_061452. FT VARIANT 73 73 A -> E (in dbSNP:rs1050409). FT /FTId=VAR_050346. FT VARIANT 76 76 V -> M (in dbSNP:rs1065382). FT /FTId=VAR_050347. FT VARIANT 90 90 K -> N (in allele Cw*07:01; FT dbSNP:rs28626310). FT /FTId=VAR_016590. FT VARIANT 97 97 A -> T (in dbSNP:rs41543814). FT /FTId=VAR_050348. FT VARIANT 101 101 S -> N (in allele Cw*07:09; FT dbSNP:rs2308557). FT /FTId=VAR_016591. FT VARIANT 104 104 N -> K (in allele Cw*07:09; FT dbSNP:rs17408553). FT /FTId=VAR_016592. FT VARIANT 119 119 L -> F (in allele Cw*07:04 and allele FT Cw*07:11; dbSNP:rs1071649). FT /FTId=VAR_016593. FT VARIANT 123 123 S -> C (in dbSNP:rs1131115). FT /FTId=VAR_059507. FT VARIANT 123 123 S -> F (in dbSNP:rs1131115). FT /FTId=VAR_059508. FT VARIANT 123 123 S -> Y (in allele Cw*07:01; FT dbSNP:rs1131115). FT /FTId=VAR_016594. FT VARIANT 137 137 Y -> H (in dbSNP:rs2308574). FT /FTId=VAR_050349. FT VARIANT 140 140 S -> F (in allele Cw*07:04 and allele FT Cw*07:11; dbSNP:rs713032). FT /FTId=VAR_016595. FT VARIANT 171 171 L -> W (in allele Cw*07:03; FT dbSNP:rs1050366). FT /FTId=VAR_016646. FT VARIANT 180 180 L -> D (in allele Cw*07:04 and allele FT Cw*07:11; requires 2 nucleotide FT substitutions). FT /FTId=VAR_016596. FT VARIANT 187 187 T -> L (in allele Cw*07:03; requires 2 FT nucleotide substitutions). FT /FTId=VAR_016647. FT VARIANT 201 201 E -> K (in allele Cw*07:04 and allele FT Cw0711; dbSNP:rs1131103). FT /FTId=VAR_016597. FT VARIANT 208 208 P -> H (in dbSNP:rs1131096). FT /FTId=VAR_061453. FT VARIANT 208 208 P -> R (in dbSNP:rs1131096). FT /FTId=VAR_061454. FT VARIANT 272 272 V -> M (in dbSNP:rs1050276). FT /FTId=VAR_050351. FT VARIANT 328 328 V -> I (in dbSNP:rs1050118). FT /FTId=VAR_050352. FT VARIANT 330 330 A -> V (in dbSNP:rs1050105). FT /FTId=VAR_050353. FT VARIANT 331 331 M -> K (in allele Cw*07:06; FT dbSNP:rs41542414). FT /FTId=VAR_016598. FT VARIANT 331 331 M -> V (in dbSNP:rs1130935). FT /FTId=VAR_050354. FT VARIANT 348 348 A -> V (in allele Cw*07:06; FT dbSNP:rs41559915). FT /FTId=VAR_016599. FT VARIANT 350 350 C -> S (in dbSNP:rs35708511). FT {ECO:0000244|PubMed:24275569}. FT /FTId=VAR_061455. FT VARIANT 363 363 T -> A (in allele Cw*07:11; FT dbSNP:rs1130838). FT /FTId=VAR_016600. FT CONFLICT 15 16 GG -> AA (in Ref. 7; AAA50217). FT {ECO:0000305}. FT CONFLICT 41 41 R -> A (in Ref. 10; AAA52665). FT {ECO:0000305}. FT CONFLICT 309 309 M -> V (in Ref. 13; AAA53259). FT {ECO:0000305}. FT STRAND 28 36 {ECO:0000244|PDB:5VGE}. FT TURN 39 41 {ECO:0000244|PDB:5VGE}. FT STRAND 45 52 {ECO:0000244|PDB:5VGE}. FT STRAND 55 61 {ECO:0000244|PDB:5VGE}. FT STRAND 64 66 {ECO:0000244|PDB:5VGE}. FT TURN 74 78 {ECO:0000244|PDB:5VGE}. FT HELIX 81 108 {ECO:0000244|PDB:5VGE}. FT STRAND 118 127 {ECO:0000244|PDB:5VGE}. FT STRAND 129 131 {ECO:0000244|PDB:5VGE}. FT STRAND 133 142 {ECO:0000244|PDB:5VGE}. FT STRAND 145 150 {ECO:0000244|PDB:5VGE}. FT STRAND 157 161 {ECO:0000244|PDB:5VGE}. FT HELIX 163 174 {ECO:0000244|PDB:5VGE}. FT HELIX 176 185 {ECO:0000244|PDB:5VGE}. FT HELIX 187 198 {ECO:0000244|PDB:5VGE}. FT HELIX 200 203 {ECO:0000244|PDB:5VGE}. FT STRAND 210 235 {ECO:0000244|PDB:5VGE}. FT STRAND 237 243 {ECO:0000244|PDB:5VGE}. FT TURN 249 251 {ECO:0000244|PDB:5VGE}. FT STRAND 261 263 {ECO:0000244|PDB:5VGE}. FT STRAND 265 274 {ECO:0000244|PDB:5VGE}. FT HELIX 278 280 {ECO:0000244|PDB:5VGE}. FT STRAND 281 287 {ECO:0000244|PDB:5VGE}. FT STRAND 294 296 {ECO:0000244|PDB:5VGE}. SQ SEQUENCE 366 AA; 40649 MW; 59C23D95FD1D0BC8 CRC64; MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ RMSGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC SNSAQGSDES LITCKA // ID 1C08_HUMAN Reviewed; 366 AA. AC P30505; P30506; P30507; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 12-SEP-2018, entry version 141. DE RecName: Full=HLA class I histocompatibility antigen, Cw-8 alpha chain; DE AltName: Full=MHC class I antigen Cw*8; DE Flags: Precursor; GN Name=HLA-C; Synonyms=HLAC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES CW*08:01 AND CW*08:02). RX PubMed=1384166; DOI=10.1111/j.1399-0039.1992.tb01943.x; RA Zemmour J., Gumperz J.E., Hildebrand W.H., Ward F.E., Marsh S.G.E., RA Williams R.C., Parham P.; RT "The molecular basis for reactivity of anti-Cw1 and anti-Cw3 RT alloantisera with HLA-B46 haplotypes."; RL Tissue Antigens 39:249-257(1992). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*08:03). RX PubMed=1317015; DOI=10.1038/357326a0; RA Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J., RA Williams R.C., Luz R., Petzl-Erler M.L., Parham P.; RT "Unusual HLA-B alleles in two tribes of Brazilian Indians."; RL Nature 357:326-329(1992). RN [3] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] RP VARIANT [LARGE SCALE ANALYSIS] MET-272, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- INTERACTION: CC P43628:KIR2DL3; NbExp=2; IntAct=EBI-6163567, EBI-8632435; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of Cw-8 are known: Cw*08:01 CC (Cw8.1), Cw*08:02 (Cw8.2) and Cw*08:03. The sequence shown is that CC of Cw*08:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M84173; AAA59687.1; -; mRNA. DR EMBL; M84174; AAA59688.1; -; mRNA. DR EMBL; Z15144; CAA78850.1; -; mRNA. DR PIR; I37135; I37135. DR PIR; I81232; I81232. DR UniGene; Hs.656020; -. DR UniGene; Hs.743218; -. DR PDB; 4NT6; X-ray; 1.84 A; A=26-298. DR PDBsum; 4NT6; -. DR ProteinModelPortal; P30505; -. DR SMR; P30505; -. DR IntAct; P30505; 7. DR SwissPalm; P30505; -. DR DMDM; 231434; -. DR MaxQB; P30505; -. DR PeptideAtlas; P30505; -. DR PRIDE; P30505; -. DR Ensembl; ENST00000400341; ENSP00000383195; ENSG00000206435. DR Ensembl; ENST00000400394; ENSP00000383244; ENSG00000206452. DR DisGeNET; 3107; -. DR GeneCards; HLA-C; -. DR HGNC; HGNC:4933; HLA-C. DR MalaCards; HLA-C; -. DR MIM; 142840; gene. DR neXtProt; NX_P30505; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-C; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 366 HLA class I histocompatibility antigen, FT Cw-8 alpha chain. FT /FTId=PRO_0000018875. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 73 73 A -> E (in dbSNP:rs1050409). FT /FTId=VAR_056483. FT VARIANT 76 76 V -> M (in dbSNP:rs1065382). FT /FTId=VAR_056484. FT VARIANT 90 90 K -> N (in dbSNP:rs28626310). FT /FTId=VAR_056485. FT VARIANT 162 162 T -> K (in allele Cw*08:02). FT /FTId=VAR_016586. FT VARIANT 176 176 T -> E (in allele Cw*08:02; requires 2 FT nucleotide substitutions). FT /FTId=VAR_016587. FT VARIANT 180 180 L -> R (in allele Cw*08:02). FT /FTId=VAR_016588. FT VARIANT 199 199 G -> R (in allele Cw*08:03). FT /FTId=VAR_016589. FT VARIANT 272 272 V -> M (in dbSNP:rs1050276). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_056486. FT STRAND 27 36 {ECO:0000244|PDB:4NT6}. FT STRAND 41 43 {ECO:0000244|PDB:4NT6}. FT STRAND 45 52 {ECO:0000244|PDB:4NT6}. FT STRAND 55 61 {ECO:0000244|PDB:4NT6}. FT STRAND 64 66 {ECO:0000244|PDB:4NT6}. FT HELIX 74 77 {ECO:0000244|PDB:4NT6}. FT HELIX 81 108 {ECO:0000244|PDB:4NT6}. FT STRAND 118 127 {ECO:0000244|PDB:4NT6}. FT STRAND 133 142 {ECO:0000244|PDB:4NT6}. FT STRAND 145 150 {ECO:0000244|PDB:4NT6}. FT STRAND 157 161 {ECO:0000244|PDB:4NT6}. FT HELIX 162 174 {ECO:0000244|PDB:4NT6}. FT HELIX 176 185 {ECO:0000244|PDB:4NT6}. FT HELIX 187 198 {ECO:0000244|PDB:4NT6}. FT HELIX 200 203 {ECO:0000244|PDB:4NT6}. FT STRAND 210 217 {ECO:0000244|PDB:4NT6}. FT STRAND 219 235 {ECO:0000244|PDB:4NT6}. FT STRAND 238 243 {ECO:0000244|PDB:4NT6}. FT HELIX 249 251 {ECO:0000244|PDB:4NT6}. FT STRAND 252 254 {ECO:0000244|PDB:4NT6}. FT STRAND 261 263 {ECO:0000244|PDB:4NT6}. FT STRAND 265 274 {ECO:0000244|PDB:4NT6}. FT HELIX 278 280 {ECO:0000244|PDB:4NT6}. FT STRAND 281 286 {ECO:0000244|PDB:4NT6}. FT STRAND 294 296 {ECO:0000244|PDB:4NT6}. SQ SEQUENCE 366 AA; 40773 MW; 2A84D41389A0486A CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVQF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEAGSHTLQ RMYGCDLGPD GRLLRGYNQF AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARTAEQL RAYLEGTCVE WLRRYLENGK KTLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWGP SSQPTIPIVG IVAGLAVLAV LAVLGAVMAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA // ID 1C12_HUMAN Reviewed; 366 AA. AC P30508; O02863; O19652; O62882; O78062; O78166; O78211; O78214; AC P30509; Q29768; Q31627; Q860R1; Q860R2; Q99528; Q9GIK4; Q9TPS4; AC Q9UM32; Q9UM33; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 22-AUG-2003, sequence version 2. DT 12-SEP-2018, entry version 153. DE RecName: Full=HLA class I histocompatibility antigen, Cw-12 alpha chain; DE AltName: Full=MHC class I antigen Cw*12; DE Flags: Precursor; GN Name=HLA-C; Synonyms=HLAC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*12:02). RX PubMed=2843461; DOI=10.1007/BF00345504; RA Takata H., Inoko H., Ando A., Haranaka M., Watanabe B., Tsuji K., RA Iri H.; RT "Cloning and analysis of HLA class I cDNA encoding a new HLA-C RT specificity Cx52."; RL Immunogenetics 28:265-270(1988). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE CW*12:02). RX PubMed=2787363; RA Takiguchi M., Nishimura I., Hayashi H., Karaki S., Kariyone A., RA Kano K.; RT "The structure and expression of genes encoding serologically RT undetected HLA-C locus antigens."; RL J. Immunol. 143:1372-1378(1989). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*12:02). RX PubMed=7905471; DOI=10.1016/0198-8859(93)90509-Y; RA Vilches C., de Pablo R., Herrero M.J., Moreno M.E., Kreisler M.; RT "Molecular cloning and polymerase chain reaction-sequence-specific RT oligonucleotide detection of the allele encoding the novel RT allospecificity HLA-Cw6.2 (Cw*1502) in Spanish gypsies."; RL Hum. Immunol. 37:259-263(1993). RN [4] RP NUCLEOTIDE SEQUENCE OF 1-298 (ALLELE CW*12:02). RC TISSUE=Peripheral blood; RA Wang H., Tokunaga K.; RT "HLA-C alleles in Japanese and a novel allele from a non-Japanese RT individual."; RL Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE CW*12:02). RA Greville W.D., Ng G., Kennedy A., Kennedy C.T., Le T., Dodd R., RA Wallace R., Dunckley H.; RT "An HLA-Cw allele detected by PCR-SSO."; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*12:03). RC TISSUE=Blood; RX PubMed=7839353; DOI=10.1111/j.1399-0039.1994.tb02379.x; RA Cereb N., Choi J.W., Lee S., Maye P., Kong Y., Yang S.Y.; RT "Identification of two new HLA-C alleles, Cw*1203 and Cw*1402, from RT the sequence analysis of seven HLA homozygous cell lines carrying HLA- RT C blank."; RL Tissue Antigens 44:193-195(1994). RN [7] RP NUCLEOTIDE SEQUENCE (ALLELE CW*12:03). RA Pablo R.; RL Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE (ALLELE CW*12:03). RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [9] RP NUCLEOTIDE SEQUENCE OF 1-298 (ALLELE CW*12:03). RC TISSUE=Peripheral blood; RA Wang H., Tokunaga K.; RT "HLA-C locus polymorphisms in Japanese."; RL Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*12:04). RX PubMed=9459510; DOI=10.1111/j.1399-0039.1998.tb02953.x; RA Vilches C., Bunce M., van Dam M., de Pablo R.; RT "A new pair of HLA-C alleles, Cw*12042 and Cw*1203, differing at the RT KIR-related dimorphism of codons 77-80."; RL Tissue Antigens 51:101-105(1998). RN [11] RP NUCLEOTIDE SEQUENCE OF 1-227 (ALLELE CW*12:04). RA Tatari Z.; RL Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases. RN [12] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES CW*12:04 AND RP CW*12:06). RX PubMed=9686604; RA Turner S., Ellexson M.E., Hickman H.D., Sidebottom D.A., RA Fernandez-Vina M., Confer D.L., Hildebrand W.H.; RT "Sequence-based typing provides a new look at HLA-C diversity."; RL J. Immunol. 161:1406-1413(1998). RN [13] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ALLELE CW*12:05). RX PubMed=9459506; DOI=10.1111/j.1399-0039.1998.tb02949.x; RA Grundschober C., Labonne M., Javaux F., Steiner Q.G., Gebuhrer L., RA Tiercy J.-M.; RT "Sequence of four new HLA-Cw alleles: a possible role of interallelic RT recombination."; RL Tissue Antigens 51:72-79(1998). RN [14] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE CW*12:07). RA Davey S., Dunn P.P.; RT "Nucleotide sequence of an HLA-Cw*1203 variant allele with a new RT polymorphic position in exon 2."; RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases. RN [15] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE CW*12:08). RX PubMed=11972880; DOI=10.1034/j.1399-0039.2002.590110.x; RA Cox S.T., Ogilvie H., Bohan E.M., Holman R., Prentice H.G., Potter M., RA Madrigal J.A., Little A.-M.; RT "Sequence of two new HLA-Cw alleles: HLA-Cw*0313 and HLA-Cw*1208."; RL Tissue Antigens 59:49-51(2002). RN [16] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE CW*12:09). RA Day S., Carter V.; RT "Identification of confirmatory sequence of Cw*1209."; RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases. RN [17] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [18] RP VARIANTS [LARGE SCALE ANALYSIS] PRO-208 AND THR-363. RX PubMed=18987736; DOI=10.1038/nature07485; RA Ley T.J., Mardis E.R., Ding L., Fulton B., McLellan M.D., Chen K., RA Dooling D., Dunford-Shore B.H., McGrath S., Hickenbotham M., Cook L., RA Abbott R., Larson D.E., Koboldt D.C., Pohl C., Smith S., Hawkins A., RA Abbott S., Locke D., Hillier L.W., Miner T., Fulton L., Magrini V., RA Wylie T., Glasscock J., Conyers J., Sander N., Shi X., Osborne J.R., RA Minx P., Gordon D., Chinwalla A., Zhao Y., Ries R.E., Payton J.E., RA Westervelt P., Tomasson M.H., Watson M., Baty J., Ivanovich J., RA Heath S., Shannon W.D., Nagarajan R., Walter M.J., Link D.C., RA Graubert T.A., DiPersio J.F., Wilson R.K.; RT "DNA sequencing of a cytogenetically normal acute myeloid leukaemia RT genome."; RL Nature 456:66-72(2008). RN [19] RP VARIANT [LARGE SCALE ANALYSIS] MET-272, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of Cw-12 are known: Cw*12:02, CC Cw*12:03, Cw*12:04, Cw*12:05, Cw*12:06, Cw*12:07, Cw*12:08 and CC Cw*12:09. The sequence shown is that of Cw*12:02. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M21963; AAA59847.1; -; mRNA. DR EMBL; M28172; AAA59670.1; -; Genomic_DNA. DR EMBL; X70856; CAA50209.1; -; mRNA. DR EMBL; X70857; CAA50210.1; -; mRNA. DR EMBL; D64152; BAA19537.1; -; mRNA. DR EMBL; D83741; BAA32615.1; -; mRNA. DR EMBL; AH008326; AAF04581.1; -; Genomic_DNA. DR EMBL; U06695; AAA92995.1; -; mRNA. DR EMBL; U06696; AAA92996.1; -; mRNA. DR EMBL; X82122; CAA57634.1; -; mRNA. DR EMBL; AJ420248; CAD12433.1; -; Genomic_DNA. DR EMBL; D64146; BAA19532.1; -; mRNA. DR EMBL; Y11843; CAA72592.1; -; mRNA. DR EMBL; X99704; CAA68035.1; -; mRNA. DR EMBL; AH006134; AAC17724.1; -; Genomic_DNA. DR EMBL; AH006135; AAC17725.1; -; Genomic_DNA. DR EMBL; Z83247; CAB05845.1; -; mRNA. DR EMBL; Z80228; CAB02409.1; -; Genomic_DNA. DR EMBL; AJ249163; CAB53538.1; -; Genomic_DNA. DR EMBL; AJ249164; CAB53539.1; -; Genomic_DNA. DR EMBL; AJ304496; CAC19018.1; -; Genomic_DNA. DR EMBL; AJ550622; CAD79471.1; -; Genomic_DNA. DR EMBL; AJ550623; CAD79472.1; -; Genomic_DNA. DR PIR; A59028; A59028. DR PIR; I37526; I37526. DR PIR; I38507; I38507. DR PIR; I54449; I54449. DR PIR; I72113; I72113. DR UniGene; Hs.656020; -. DR UniGene; Hs.743218; -. DR ProteinModelPortal; P30508; -. DR SMR; P30508; -. DR IntAct; P30508; 18. DR SwissPalm; P30508; -. DR DMDM; 34223723; -. DR EPD; P30508; -. DR MaxQB; P30508; -. DR PeptideAtlas; P30508; -. DR PRIDE; P30508; -. DR Ensembl; ENST00000420206; ENSP00000410214; ENSG00000228299. DR DisGeNET; 3107; -. DR GeneCards; HLA-C; -. DR HGNC; HGNC:4933; HLA-C. DR MalaCards; HLA-C; -. DR MIM; 142840; gene. DR neXtProt; NX_P30508; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-C; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 366 HLA class I histocompatibility antigen, FT Cw-12 alpha chain. FT /FTId=PRO_0000018876. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 73 73 A -> E (in dbSNP:rs1050409). FT /FTId=VAR_056487. FT VARIANT 76 76 V -> M (in dbSNP:rs1065382). FT /FTId=VAR_056488. FT VARIANT 90 90 K -> N (in allele Cw*12:08; FT dbSNP:rs28626310). FT /FTId=VAR_016622. FT VARIANT 97 97 A -> T (in allele Cw*12:05 and allele FT Cw*12:09; dbSNP:rs41543814). FT /FTId=VAR_016623. FT VARIANT 101 101 S -> G (in allele Cw*12:07). FT /FTId=VAR_016624. FT VARIANT 101 101 S -> N (in allele Cw*12:04, allele FT Cw*12:05 and allele Cw*12:09; FT dbSNP:rs2308557). FT /FTId=VAR_016625. FT VARIANT 104 104 N -> K (in allele Cw*12:04, allele FT Cw*12:05 and allele Cw*12:09; FT dbSNP:rs17408553). FT /FTId=VAR_016626. FT VARIANT 121 121 R -> W (in allele Cw*12:03, allele FT Cw*12:04, allele Cw*12:05, allele FT Cw*12:06, allele Cw*12:07 and allele FT Cw*12:09). FT /FTId=VAR_016627. FT VARIANT 137 137 Y -> H (in dbSNP:rs2308574). FT /FTId=VAR_056489. FT VARIANT 144 144 G -> V (in allele Cw*12:06). FT /FTId=VAR_016628. FT VARIANT 180 180 W -> R (in allele Cw*12:09). FT /FTId=VAR_016629. FT VARIANT 201 201 E -> K (in dbSNP:rs1131103). FT /FTId=VAR_056491. FT VARIANT 208 208 H -> P. {ECO:0000269|PubMed:18987736}. FT /FTId=VAR_054155. FT VARIANT 272 272 V -> M (in dbSNP:rs1050276). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_056492. FT VARIANT 363 363 A -> T. {ECO:0000269|PubMed:18987736}. FT /FTId=VAR_054156. FT CONFLICT 25 25 C -> G (in Ref. 1). {ECO:0000305}. FT CONFLICT 140 140 S -> V (in Ref. 1; AAA59847). FT {ECO:0000305}. SQ SEQUENCE 366 AA; 40886 MW; 598C8795CD033FB7 CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV SLRNLRGYYN QSEAGSHTLQ RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQW RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVMAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA // ID 1C14_HUMAN Reviewed; 366 AA. AC P30510; O62879; O78178; Q29641; Q30192; Q9MY35; Q9TQJ5; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 29-AUG-2003, sequence version 2. DT 12-SEP-2018, entry version 142. DE RecName: Full=HLA class I histocompatibility antigen, Cw-14 alpha chain; DE AltName: Full=MHC class I antigen Cw*14; DE Flags: Precursor; GN Name=HLA-C; Synonyms=HLAC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE CW*14:02), AND VARIANT RP MET-272. RX PubMed=2787363; RA Takiguchi M., Nishimura I., Hayashi H., Karaki S., Kariyone A., RA Kano K.; RT "The structure and expression of genes encoding serologically RT undetected HLA-C locus antigens."; RL J. Immunol. 143:1372-1378(1989). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*14:02). RC TISSUE=Blood; RX PubMed=7839353; DOI=10.1111/j.1399-0039.1994.tb02379.x; RA Cereb N., Choi J.W., Lee S., Maye P., Kong Y., Yang S.Y.; RT "Identification of two new HLA-C alleles, Cw*1203 and Cw*1402, from RT the sequence analysis of seven HLA homozygous cell lines carrying HLA- RT C blank."; RL Tissue Antigens 44:193-195(1994). RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE CW*14:02). RA Zhang L., Ellexson M.E., Hildebrand W.H.; RL Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] OF 26-298 (ALLELE CW*14:02). RC TISSUE=Blood; RX PubMed=8795149; DOI=10.1111/j.1399-0039.1996.tb02584.x; RA Wang H., Tokunaga K., Ogawa A., Akaza T., Tadokoro K., Takiguchi M., RA Shibata Y., Juji T.; RT "DNA typing of Cw*14 alleles in Japanese and the corrected sequence of RT Cw*1402."; RL Tissue Antigens 47:442-446(1996). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE CW*14:02). RX PubMed=9686604; RA Turner S., Ellexson M.E., Hickman H.D., Sidebottom D.A., RA Fernandez-Vina M., Confer D.L., Hildebrand W.H.; RT "Sequence-based typing provides a new look at HLA-C diversity."; RL J. Immunol. 161:1406-1413(1998). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*14:03). RC TISSUE=Blood; RX PubMed=7499177; DOI=10.1016/0198-8859(95)00041-2; RA Wang H., Tokunaga K., Ishikawa Y., Lin L., Kashiwase K., Nakajima F., RA Ogawa A., Kuwata S., Akaza T., Tadokoro K., Shibata Y., Yoshikura H., RA Juji T.; RT "A new HLA-C allele, Cw*1403, associated with HLA-B44 in Japanese."; RL Hum. Immunol. 43:295-300(1995). RN [7] RP NUCLEOTIDE SEQUENCE (ALLELE CW*14:03). RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE CW*14:04). RX PubMed=10912513; DOI=10.1007/s002510000178; RA Santos S., Vicario J.L., Aviles M.J., Garcia-Sanchez F., Balas A.; RT "HLA-Cw*1404: a new HLA-C allele with a hybrid 77Asn-80Asn NK motif."; RL Immunogenetics 51:610-612(2000). RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [10] RP VARIANT [LARGE SCALE ANALYSIS] MET-272, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of Cw-14 are known: Cw*14:02 CC (CB-1), Cw*14:03 (CX44) and Cw*14:04. The sequence shown is that CC of Cw*14:02. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M28171; AAA59669.1; -; Genomic_DNA. DR EMBL; U06487; AAA92994.1; -; mRNA. DR EMBL; U41386; AAC32743.1; -; mRNA. DR EMBL; D49820; BAA89793.1; -; mRNA. DR EMBL; AH006136; AAC17726.1; -; Genomic_DNA. DR EMBL; D31817; BAA06604.1; -; mRNA. DR EMBL; AJ420249; CAD12434.1; -; Genomic_DNA. DR EMBL; AH007516; AAD21014.1; -; Genomic_DNA. DR PIR; I56034; I56034. DR UniGene; Hs.656020; -. DR UniGene; Hs.743218; -. DR ProteinModelPortal; P30510; -. DR SMR; P30510; -. DR IntAct; P30510; 4. DR SwissPalm; P30510; -. DR MaxQB; P30510; -. DR PeptideAtlas; P30510; -. DR PRIDE; P30510; -. DR Ensembl; ENST00000438171; ENSP00000393374; ENSG00000237022. DR DisGeNET; 3107; -. DR GeneCards; HLA-C; -. DR HGNC; HGNC:4933; HLA-C. DR MalaCards; HLA-C; -. DR MIM; 142840; gene. DR neXtProt; NX_P30510; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-C; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 366 HLA class I histocompatibility antigen, FT Cw-14 alpha chain. FT /FTId=PRO_0000018877. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 45 45 R -> H (in allele Cw*14:03). FT /FTId=VAR_016636. FT VARIANT 73 73 A -> E (in dbSNP:rs1050409). FT /FTId=VAR_056493. FT VARIANT 76 76 V -> M (in dbSNP:rs1065382). FT /FTId=VAR_056494. FT VARIANT 90 90 K -> N (in dbSNP:rs28626310). FT /FTId=VAR_056495. FT VARIANT 97 97 T -> A (in allele Cw*14:04). FT /FTId=VAR_016637. FT VARIANT 101 101 S -> N (in allele Cw*14:03). FT /FTId=VAR_016638. FT VARIANT 137 137 Y -> H (in dbSNP:rs2308574). FT /FTId=VAR_056496. FT VARIANT 201 201 E -> K (in dbSNP:rs1131103). FT /FTId=VAR_056498. FT VARIANT 272 272 V -> M (in dbSNP:rs1050276). FT {ECO:0000244|PubMed:25944712, FT ECO:0000269|PubMed:2787363}. FT /FTId=VAR_056499. FT CONFLICT 16 16 A -> T (in Ref. 2; AAA92994). FT {ECO:0000305}. FT CONFLICT 43 43 E -> G (in Ref. 2; AAA92994). FT {ECO:0000305}. FT CONFLICT 202 202 T -> S (in Ref. 1; AAA59669). FT {ECO:0000305}. SQ SEQUENCE 366 AA; 40838 MW; 792D335D12D6547E CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEAGSHTLQ WMFGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQR RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA // ID 1C15_HUMAN Reviewed; 366 AA. AC Q07000; O78165; Q29864; Q29991; Q31605; Q9BD28; Q9GJ33; Q9MY49; DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1994, sequence version 1. DT 12-SEP-2018, entry version 142. DE RecName: Full=HLA class I histocompatibility antigen, Cw-15 alpha chain; DE AltName: Full=MHC class I antigen Cw*15; DE Flags: Precursor; GN Name=HLA-C; Synonyms=HLAC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*15:02). RX PubMed=7905471; DOI=10.1016/0198-8859(93)90509-Y; RA Vilches C., de Pablo R., Herrero M.J., Moreno M.E., Kreisler M.; RT "Molecular cloning and polymerase chain reaction-sequence-specific RT oligonucleotide detection of the allele encoding the novel RT allospecificity HLA-Cw6.2 (Cw*1502) in Spanish gypsies."; RL Hum. Immunol. 37:259-263(1993). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*15:02). RC TISSUE=Peripheral blood; RA Wang H., Tokunaga K.; RT "HLA-C locus polymorphisms in Japanese."; RL Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE CW*15:02). RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [4] RP NUCLEOTIDE SEQUENCE OF 1-275 (ALLELE CW*15:02). RA Witter K., Zahn R., Scholz S., Albert E.; RT "Group specific amplification and sequencing of HLA-C locus."; RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE (ALLELE CW*15:03). RA Domena J.D.; RL Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*15:04). RX PubMed=8225443; DOI=10.1007/BF00171805; RA Pablo R., Vilches C., Moreno M.E., Kreisler M.; RT "A novel HLA-C allele (Cw*1504) related to the Cw6.2 phenotype."; RL Immunogenetics 39:79-79(1994). RN [7] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*15:05). RX PubMed=8082899; DOI=10.1007/BF00189983; RA Vilches C., de Pablo R., Herrero M.J., Moreno M.E., Kreisler M.; RT "Cw*1505: a novel HLA-C allele isolated from a B*7301 haplotype."; RL Immunogenetics 40:313-313(1994). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*15:05). RX PubMed=8773323; DOI=10.1111/j.1399-0039.1996.tb02561.x; RA Sanz L., Vilches C., de Pablo R., Bunce M., Moreno M.E., Kreisler M.; RT "Haplotypic association of two new HLA class I alleles: Cw*15052 and RT B*0706: evolutionary relationships of HLA-Cw*15 alleles."; RL Tissue Antigens 47:329-332(1996). RN [9] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE CW*15:10). RA Tamouza R., Schaeffer V., Marzais F., Poirier J.C., Fortier C., RA Charron D.; RT "New HLA-Cw*15 sequence."; RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE CW*15:11). RA Greville W.D., Chapman G., Le T., Dodd R., Taverniti A., Dunckley H.; RT "Novel HLA-Cw allele detected by PCR-SSO."; RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases. RN [11] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110. RC TISSUE=Leukemic T-cell; RX PubMed=19349973; DOI=10.1038/nbt.1532; RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., RA Schiess R., Aebersold R., Watts J.D.; RT "Mass-spectrometric identification and relative quantification of N- RT linked cell surface glycoproteins."; RL Nat. Biotechnol. 27:378-386(2009). RN [12] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [13] RP VARIANT [LARGE SCALE ANALYSIS] LYS-90, VARIANT [LARGE SCALE ANALYSIS] RP MET-272, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- INTERACTION: CC P43626:KIR2DL1; NbExp=2; IntAct=EBI-1058803, EBI-8684277; CC Q14953:KIR2DS5; NbExp=6; IntAct=EBI-1058803, EBI-16823921; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of Cw-15 are known: Cw*15:02, CC Cw*15:03, Cw*15:04, Cw*15:05, Cw*15:10 and Cw*15:11. The sequence CC shown is that of Cw*15:02. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X67818; CAA48029.1; -; mRNA. DR EMBL; D83031; BAA32614.1; -; mRNA. DR EMBL; AJ420250; CAD12435.1; -; Genomic_DNA. DR EMBL; AJ272049; CAB75584.1; -; Genomic_DNA. DR EMBL; M99388; AAA88087.1; -; mRNA. DR EMBL; X73518; CAA51917.1; -; mRNA. DR EMBL; X78343; CAA55138.1; -; mRNA. DR EMBL; X87841; CAA61110.1; -; mRNA. DR EMBL; AF302134; AAG33823.1; -; Genomic_DNA. DR EMBL; AF302133; AAG33823.1; JOINED; Genomic_DNA. DR EMBL; AH010335; AAK07656.1; -; Genomic_DNA. DR PIR; I37523; I37523. DR PIR; I37527; I37527. DR PIR; I37544; I37544. DR UniGene; Hs.656020; -. DR UniGene; Hs.743218; -. DR ProteinModelPortal; Q07000; -. DR SMR; Q07000; -. DR IntAct; Q07000; 6. DR iPTMnet; Q07000; -. DR SwissPalm; Q07000; -. DR DMDM; 543713; -. DR EPD; Q07000; -. DR MaxQB; Q07000; -. DR PeptideAtlas; Q07000; -. DR PRIDE; Q07000; -. DR Ensembl; ENST00000400341; ENSP00000383195; ENSG00000206435. DR Ensembl; ENST00000400394; ENSP00000383244; ENSG00000206452. DR DisGeNET; 3107; -. DR GeneCards; HLA-C; -. DR H-InvDB; HIX0167430; -. DR HGNC; HGNC:4933; HLA-C. DR MalaCards; HLA-C; -. DR MIM; 142840; gene. DR neXtProt; NX_Q07000; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-C; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 366 HLA class I histocompatibility antigen, FT Cw-15 alpha chain. FT /FTId=PRO_0000018878. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:19349973}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 40 40 G -> S (in allele Cw*15:11). FT /FTId=VAR_016639. FT VARIANT 45 45 H -> R (in allele Cw*15:10). FT /FTId=VAR_016640. FT VARIANT 73 73 A -> E (in dbSNP:rs1050409). FT /FTId=VAR_056500. FT VARIANT 76 76 V -> M (in dbSNP:rs1065382). FT /FTId=VAR_056501. FT VARIANT 90 90 N -> K (in allele Cw*15:11). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_016641. FT VARIANT 97 97 T -> A (in allele Cw*15:03). FT /FTId=VAR_016642. FT VARIANT 137 137 H -> Y (in allele Cw*15:04). FT /FTId=VAR_016643. FT VARIANT 140 140 L -> F (in allele Cw*15:05). FT /FTId=VAR_016644. FT VARIANT 140 140 L -> S (in allele Cw*15:04). FT /FTId=VAR_016645. FT VARIANT 201 201 E -> K (in dbSNP:rs1131103). FT /FTId=VAR_056503. FT VARIANT 272 272 V -> M (in dbSNP:rs1050276). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_056504. FT CONFLICT 5 5 A -> T (in Ref. 2; BAA32614). FT {ECO:0000305}. SQ SEQUENCE 366 AA; 40863 MW; FDF703B7AFB05FDD CRC64; MRVMAPRTLL LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPHFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQTDRV NLRKLRGYYN QSEAGSHIIQ RMYGCDLGPD GRLLRGHDQL AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQL RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVMAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA // ID 1C16_HUMAN Reviewed; 366 AA. AC Q29960; O78091; O78202; Q29862; Q29959; Q9MY74; Q9MYI3; Q9TNZ8; DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 12-SEP-2018, entry version 139. DE RecName: Full=HLA class I histocompatibility antigen, Cw-16 alpha chain; DE AltName: Full=MHC class I antigen Cw*16; DE Flags: Precursor; GN Name=HLA-C; Synonyms=HLAC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*16:01), AND ALTERNATIVE RP SPLICING. RX PubMed=2914713; DOI=10.1007/BF00395855; RA Cianetti L., Testa U., Scotto L., la Valle R., Simeone A., Boccoli G., RA Giannella G., Peschle C., Boncinelli E.; RT "Three new class I HLA alleles: structure of mRNAs and alternative RT mechanisms of processing."; RL Immunogenetics 29:80-91(1989). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*16:02). RX PubMed=7860363; DOI=10.1016/0198-8859(94)90011-6; RA Vilches C., Herrero M.J., de Pablo R., Moreno M.E., Bunce M., RA Kreisler M.; RT "Molecular characterization of a novel, serologically detectable, HLA- RT C allele: Cw*1602."; RL Hum. Immunol. 41:167-170(1994). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-338 (ALLELE CW*16:04). RX PubMed=10488744; DOI=10.1034/j.1399-0039.1999.540208.x; RA van der Vlies S.A., Voorter C.E., van den Berg-Loonen E.M.; RT "There is more to HLA -C than exons 2 and 3: sequencing exons 1, 4 and RT 5."; RL Tissue Antigens 54:169-177(1999). RN [4] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE CW*16:04). RX PubMed=9686604; RA Turner S., Ellexson M.E., Hickman H.D., Sidebottom D.A., RA Fernandez-Vina M., Confer D.L., Hildebrand W.H.; RT "Sequence-based typing provides a new look at HLA-C diversity."; RL J. Immunol. 161:1406-1413(1998). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE CW*16:04). RX PubMed=9459506; DOI=10.1111/j.1399-0039.1998.tb02949.x; RA Grundschober C., Labonne M., Javaux F., Steiner Q.G., Gebuhrer L., RA Tiercy J.-M.; RT "Sequence of four new HLA-Cw alleles: a possible role of interallelic RT recombination."; RL Tissue Antigens 51:72-79(1998). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [7] RP VARIANT [LARGE SCALE ANALYSIS] MET-272, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000250}. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- INTERACTION: CC P43628:KIR2DL3; NbExp=2; IntAct=EBI-6163576, EBI-8632435; CC -!- SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I CC membrane protein. CC -!- SUBCELLULAR LOCATION: Isoform 2: Secreted. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q29960-1; Sequence=Displayed; CC Name=2; CC IsoId=Q29960-2; Sequence=VSP_008096; CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of Cw-16 are known: Cw*16:01, CC Cw*16:02 (CW*CL10V) and Cw*16:04. The sequence shown is that of CC Cw*16:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M24097; AAA59656.1; -; mRNA. DR EMBL; M24097; AAA59657.1; -; mRNA. DR EMBL; X76189; CAA53783.1; -; mRNA. DR EMBL; AJ011883; CAB65547.1; -; Genomic_DNA. DR EMBL; Y18657; CAB72095.1; -; Genomic_DNA. DR EMBL; Y18658; CAB72095.1; JOINED; Genomic_DNA. DR EMBL; Y18659; CAB72095.1; JOINED; Genomic_DNA. DR EMBL; Y18139; CAB71932.1; -; Genomic_DNA. DR EMBL; AH006138; AAC17728.1; -; Genomic_DNA. DR EMBL; Z75172; CAA99487.1; -; Genomic_DNA. DR PIR; A59028; A59028. DR PIR; S42823; S42823. DR UniGene; Hs.656020; -. DR UniGene; Hs.743218; -. DR ProteinModelPortal; Q29960; -. DR SMR; Q29960; -. DR IntAct; Q29960; 6. DR SwissPalm; Q29960; -. DR DMDM; 34305705; -. DR MaxQB; Q29960; -. DR PeptideAtlas; Q29960; -. DR PRIDE; Q29960; -. DR Ensembl; ENST00000438171; ENSP00000393374; ENSG00000237022. DR UCSC; uc063wnd.1; human. [Q29960-1] DR DisGeNET; 3107; -. DR GeneCards; HLA-C; -. DR H-InvDB; HIX0078594; -. DR HGNC; HGNC:4933; HLA-C. DR MalaCards; HLA-C; -. DR MIM; 142840; gene. DR neXtProt; NX_Q29960; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-C; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Alternative splicing; Cell membrane; Complete proteome; KW Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I; Polymorphism; KW Reference proteome; Secreted; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 366 HLA class I histocompatibility antigen, FT Cw-16 alpha chain. FT /FTId=PRO_0000018879. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VAR_SEQ 299 338 Missing (in isoform 2). {ECO:0000305}. FT /FTId=VSP_008096. FT VARIANT 73 73 A -> E (in dbSNP:rs1050409). FT /FTId=VAR_056505. FT VARIANT 76 76 V -> M (in dbSNP:rs1065382). FT /FTId=VAR_056506. FT VARIANT 90 90 K -> N (in dbSNP:rs28626310). FT /FTId=VAR_056507. FT VARIANT 101 101 S -> N (in allele Cw*16:02). FT /FTId=VAR_016630. FT VARIANT 104 104 N -> K (in allele Cw*16:02). FT /FTId=VAR_016631. FT VARIANT 137 137 Y -> H (in dbSNP:rs2308574). FT /FTId=VAR_056508. FT VARIANT 153 153 H -> D (in allele Cw*16:02 and allele FT Cw*16:04). FT /FTId=VAR_016632. FT VARIANT 157 157 C -> W (in allele Cw*16:02 and allele FT Cw*16:04). FT /FTId=VAR_016633. FT VARIANT 180 180 Q -> W (in allele Cw*16:04; requires 2 FT nucleotide substitutions). FT /FTId=VAR_016634. FT VARIANT 201 201 E -> K (in dbSNP:rs1131103). FT /FTId=VAR_056510. FT VARIANT 272 272 V -> M (in dbSNP:rs1050276). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_056511. SQ SEQUENCE 366 AA; 40753 MW; 5F8001BB016F1610 CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEAGSHTLQ WMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEHLRSCTAA DTAAQITQRK WEAARAAEQQ RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHLVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA // ID 1C17_HUMAN Reviewed; 372 AA. AC Q95604; O02864; O02958; Q29643; Q9MY30; DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 12-SEP-2018, entry version 141. DE RecName: Full=HLA class I histocompatibility antigen, Cw-17 alpha chain; DE AltName: Full=MHC class I antigen Cw*17; DE Flags: Precursor; GN Name=HLA-C; Synonyms=D6S204, HLA-JY3, HLAC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*17:01). RX PubMed=9211742; DOI=10.1007/s002510050259; RA Wells R.S., Seielstad M.T., Bunce M., Tyan D.B., Bekele E., Parham P.; RT "Cw*1701 defines a divergent african HLA-C allelic lineage."; RL Immunogenetics 46:173-180(1997). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*17:01). RX PubMed=9098935; DOI=10.1111/j.1399-0039.1997.tb02749.x; RA Herrero M.J., Vilches C., de Pablo R., Puente S., Kreisler M.; RT "The complete primary structure of Cw*1701 reveals a highly divergent RT HLA class I molecule."; RL Tissue Antigens 49:267-270(1997). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE CW*17:01). RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-289 (ALLELE CW*17:02). RC TISSUE=Peripheral blood; RA Wang H., Tokunaga K.; RT "HLA-C locus polymorphisms in Japanese."; RL Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-338 (ALLELE CW*17:03). RX PubMed=10488744; DOI=10.1034/j.1399-0039.1999.540208.x; RA van der Vlies S.A., Voorter C.E., van den Berg-Loonen E.M.; RT "There is more to HLA -C than exons 2 and 3: sequencing exons 1, 4 and RT 5."; RL Tissue Antigens 54:169-177(1999). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] OF 26-298 (ALLELE CW*17:01). RC TISSUE=Blood; RA Yang S., Cereb N.; RT "Nucleotide sequence analysis of HLA-Cw blank alleles from seven B RT cell lines."; RL Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases. RN [7] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110. RC TISSUE=Liver; RX PubMed=19159218; DOI=10.1021/pr8008012; RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; RT "Glycoproteomics analysis of human liver tissue by combination of RT multiple enzyme digestion and hydrazide chemistry."; RL J. Proteome Res. 8:651-661(2009). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- INTERACTION: CC P43626:KIR2DL1; NbExp=2; IntAct=EBI-6163558, EBI-8684277; CC Q14953:KIR2DS5; NbExp=6; IntAct=EBI-6163558, EBI-16823921; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC {ECO:0000250}. CC -!- POLYMORPHISM: Cw*17 appears at low frequencies in Caucasoid and CC Mongoloid populations (gene frequency 0.41 % in English CC Caucasoids, 0% in Japanese), but seems to be a common specificity CC in populations of African origin (PubMed:9098935). The following CC alleles of Cw-17 are known: Cw*17:01, Cw*17:02 and Cw*17:03. The CC sequence shown is that of Cw*17:01. {ECO:0000269|PubMed:9098935}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; U62824; AAB67322.1; -; mRNA. DR EMBL; X98742; CAA67294.1; -; mRNA. DR EMBL; Y10520; CAA71531.1; -; mRNA. DR EMBL; AJ420252; CAD12437.1; -; Genomic_DNA. DR EMBL; D64149; BAA20857.1; -; mRNA. DR EMBL; Y18537; CAB71837.1; -; Genomic_DNA. DR EMBL; Y18538; CAB71837.1; JOINED; Genomic_DNA. DR EMBL; Y18539; CAB71837.1; JOINED; Genomic_DNA. DR EMBL; Y18540; CAB71837.1; JOINED; Genomic_DNA. DR EMBL; Y18541; CAB71837.1; JOINED; Genomic_DNA. DR EMBL; U06835; AAA17674.1; -; mRNA. DR PIR; A59028; A59028. DR UniGene; Hs.656020; -. DR UniGene; Hs.743218; -. DR ProteinModelPortal; Q95604; -. DR SMR; Q95604; -. DR IntAct; Q95604; 7. DR iPTMnet; Q95604; -. DR SwissPalm; Q95604; -. DR DMDM; 34395506; -. DR EPD; Q95604; -. DR MaxQB; Q95604; -. DR PeptideAtlas; Q95604; -. DR PRIDE; Q95604; -. DR Ensembl; ENST00000400341; ENSP00000383195; ENSG00000206435. DR Ensembl; ENST00000400394; ENSP00000383244; ENSG00000206452. DR DisGeNET; 3107; -. DR GeneCards; HLA-C; -. DR HGNC; HGNC:4933; HLA-C. DR MalaCards; HLA-C; -. DR MIM; 142840; gene. DR neXtProt; NX_Q95604; -. DR HOVERGEN; HBG016709; -. DR InParanoid; Q95604; -. DR PhylomeDB; Q95604; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-C; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 372 HLA class I histocompatibility antigen, FT Cw-17 alpha chain. FT /FTId=PRO_0000018880. FT TOPO_DOM 25 317 Extracellular. {ECO:0000255}. FT TRANSMEM 318 338 Helical. {ECO:0000255}. FT TOPO_DOM 339 372 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 317 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:19159218}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 7 8 QA -> RT (in allele Cw*17:02). FT /FTId=VAR_016648. FT VARIANT 10 10 L -> I (in allele Cw*17:02). FT /FTId=VAR_016649. FT VARIANT 24 24 A -> T (in allele Cw*17:03). FT /FTId=VAR_016650. FT VARIANT 73 73 A -> E (in dbSNP:rs1050409). FT /FTId=VAR_056512. FT VARIANT 76 76 V -> M (in dbSNP:rs1065382). FT /FTId=VAR_056513. FT VARIANT 90 90 K -> N (in dbSNP:rs28626310). FT /FTId=VAR_056514. FT VARIANT 97 97 A -> T (in dbSNP:rs41543814). FT /FTId=VAR_056515. FT VARIANT 272 272 V -> M (in dbSNP:rs1050276). FT /FTId=VAR_056516. SQ SEQUENCE 372 AA; 41238 MW; D5DDCE6361D93AA2 CRC64; MRVMAPQALL LLLSGALALI ETWAGSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV NLRKLRGYYN QSEAGSHTIQ RMYGCDLGPD GRLLRGYNQF AYDGKDYIAL NEDLRSWTAA DTAAQISQRK LEAAREAEQL RAYLEGECVE WLRGYLENGK ETLQRAERPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL QEPCTLRWKP SSQPTIPNLG IVSGPAVLAV LAVLAVLAVL GAVVAAVIHR RKSSGGKGGS CSQAASSNSA QGSDESLIAC KA // ID 1C18_HUMAN Reviewed; 366 AA. AC Q29865; O78203; P79498; DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 12-SEP-2018, entry version 130. DE RecName: Full=HLA class I histocompatibility antigen, Cw-18 alpha chain; DE AltName: Full=MHC class I antigen Cw*18; DE Flags: Precursor; GN Name=HLA-C; Synonyms=HLAC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*18:01). RX PubMed=9008313; DOI=10.1111/j.1399-0039.1996.tb02694.x; RA Vilches C., Bunce M., Sanz L., de Pablo R., Puente S., Kreisler M.; RT "Molecular cloning of two new HLA-C alleles: Cw*1801 and Cw*0706."; RL Tissue Antigens 48:698-702(1996). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE CW*18:01). RX PubMed=12622774; DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE CW*18:01). RX PubMed=9459506; DOI=10.1111/j.1399-0039.1998.tb02949.x; RA Grundschober C., Labonne M., Javaux F., Steiner Q.G., Gebuhrer L., RA Tiercy J.-M.; RT "Sequence of four new HLA-Cw alleles: a possible role of interallelic RT recombination."; RL Tissue Antigens 51:72-79(1998). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*18:02). RX PubMed=9234488; DOI=10.1111/j.1399-0039.1997.tb02814.x; RA Vilches C., Bunce M., de Pablo R., Moreno M.E., Puente S., Sanz L., RA Kreisler M.; RT "The novel HLA-Cw*1802 allele is associated with B*5703 in the Bubi RT population from Equatorial Guinea."; RL Tissue Antigens 49:644-648(1997). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [6] RP VARIANT [LARGE SCALE ANALYSIS] MET-272, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250|UniProtKB:P01892}. CC -!- INTERACTION: CC P43626:KIR2DL1; NbExp=2; IntAct=EBI-13917304, EBI-8684277; CC Q14953:KIR2DS5; NbExp=6; IntAct=EBI-13917304, EBI-16823921; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment through CC interaction with human herpesvirus 8 MIR1 protein. This targets CC the protein for rapid degradation via the ubiquitin system (By CC similarity). {ECO:0000250}. CC -!- POLYMORPHISM: The following alleles of Cw-18 are known: Cw*18:01 CC (Cw*04GB) and Cw*18:02 (Cw*18GB). The sequence shown is that of CC Cw*18:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X96582; CAA65401.1; -; mRNA. DR EMBL; AJ420253; CAD12438.1; -; Genomic_DNA. DR EMBL; Z80227; CAB02408.1; -; Genomic_DNA. DR EMBL; Y09156; CAA70354.1; -; mRNA. DR UniGene; Hs.656020; -. DR UniGene; Hs.743218; -. DR ProteinModelPortal; Q29865; -. DR SMR; Q29865; -. DR IntAct; Q29865; 6. DR SwissPalm; Q29865; -. DR DMDM; 34304188; -. DR EPD; Q29865; -. DR MaxQB; Q29865; -. DR PeptideAtlas; Q29865; -. DR PRIDE; Q29865; -. DR Ensembl; ENST00000420206; ENSP00000410214; ENSG00000228299. DR DisGeNET; 3107; -. DR GeneCards; HLA-C; -. DR HGNC; HGNC:4933; HLA-C. DR HPA; HPA031454; -. DR MalaCards; HLA-C; -. DR MIM; 142840; gene. DR neXtProt; NX_Q29865; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-C; -. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 366 HLA class I histocompatibility antigen, FT Cw-18 alpha chain. FT /FTId=PRO_0000018881. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 10 10 L -> I (in dbSNP:rs2308527). FT /FTId=VAR_059509. FT VARIANT 43 43 E -> K (in dbSNP:rs1050438). FT /FTId=VAR_056517. FT VARIANT 48 48 S -> A (in dbSNP:rs707911). FT /FTId=VAR_061456. FT VARIANT 48 48 S -> P (in dbSNP:rs707911). FT /FTId=VAR_061457. FT VARIANT 48 48 S -> T (in dbSNP:rs707911). FT /FTId=VAR_061458. FT VARIANT 73 73 A -> E (in dbSNP:rs1050409). FT /FTId=VAR_056518. FT VARIANT 76 76 V -> M (in dbSNP:rs1065382). FT /FTId=VAR_056519. FT VARIANT 90 90 K -> N (in dbSNP:rs28626310). FT /FTId=VAR_056520. FT VARIANT 97 97 A -> T (in dbSNP:rs41543814). FT /FTId=VAR_056521. FT VARIANT 201 201 E -> K (in dbSNP:rs1131103). FT /FTId=VAR_056523. FT VARIANT 272 272 V -> M (in dbSNP:rs1050276). FT {ECO:0000244|PubMed:25944712}. FT /FTId=VAR_056524. FT VARIANT 319 319 V -> A (in allele Cw*18:02). FT /FTId=VAR_016635. SQ SEQUENCE 366 AA; 40933 MW; 67CE7E948E4327D8 CRC64; MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV NLRKLRGYYN QSEDGSHTLQ RMFGCDLGPD GRLLRGYNQF AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQR RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWKP SSQPTIPIVG IVAGLAVLVV LAVLGAVVAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA // ID 1C28_PANTR Reviewed; 346 AA. AC P16215; DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1990, sequence version 1. DT 23-MAY-2018, entry version 108. DE RecName: Full=Patr class I histocompatibility antigen, CH28 alpha chain; DE AltName: Full=ChLa class I histocompatibility antigen, CH28 alpha chain; DE Flags: Precursor; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1690682; DOI=10.1111/j.1600-065X.1990.tb00040.x; RA Lawlor D.A., Warren E., Ward F.E., Parham P.; RT "Comparison of class I MHC alleles in humans and apes."; RL Immunol. Rev. 113:147-185(1990). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=3412487; DOI=10.1038/335268a0; RA Lawlor D.A., Ward F.E., Ennis P.D., Jackson A.P., Parham P.; RT "HLA-A and B polymorphisms predate the divergence of humans and RT chimpanzees."; RL Nature 335:268-271(1988). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M30685; AAA87973.1; -; mRNA. DR PIR; S07114; S07114. DR RefSeq; NP_001122670.1; NM_001129198.1. DR UniGene; Ptr.6324; -. DR ProteinModelPortal; P16215; -. DR SMR; P16215; -. DR GeneID; 100169977; -. DR KEGG; ptr:100169977; -. DR CTD; 100169977; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR Proteomes; UP000002277; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 21 {ECO:0000250}. FT CHAIN 22 346 Patr class I histocompatibility antigen, FT CH28 alpha chain. FT /FTId=PRO_0000018915. FT TOPO_DOM 22 305 Extracellular. {ECO:0000255}. FT TRANSMEM 306 329 Helical. {ECO:0000255}. FT TOPO_DOM 330 346 Cytoplasmic. {ECO:0000255}. FT DOMAIN 206 294 Ig-like C1-type. FT REGION 22 111 Alpha-1. FT REGION 112 203 Alpha-2. FT REGION 204 295 Alpha-3. FT REGION 296 305 Connecting peptide. FT CARBOHYD 107 107 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 122 185 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 224 280 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 346 AA; 39085 MW; F83E882D5C2E0971 CRC64; MAPRSLLLLF SGALALTETW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WERTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL QRADPPKAHI AHHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPAGDG NFQKWAAVVV PSGEEQRYTC HVQHEGLPQP LTLRWEQSPQ PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAV // ID 1OKO_GORGO Reviewed; 362 AA. AC P30388; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 25-OCT-2017, entry version 89. DE RecName: Full=Class I histocompatibility antigen, Gogo-OKO alpha chain; DE Flags: Precursor; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1744581; DOI=10.1084/jem.174.6.1491; RA Lawlor D.A., Warren E., Taylor P., Parham P.; RT "Gorilla class I major histocompatibility complex alleles: comparison RT to human and chimpanzee class I."; RL J. Exp. Med. 174:1491-1509(1991). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X60692; CAA43100.1; -; mRNA. DR PIR; JH0538; JH0538. DR ProteinModelPortal; P30388; -. DR SMR; P30388; -. DR PRIDE; P30388; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000001519; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 362 Class I histocompatibility antigen, Gogo- FT OKO alpha chain. FT /FTId=PRO_0000018909. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 362 AA; 40756 MW; BFE4D9A72C55649D CRC64; MAVVAPRTLL LLLSGTLALT RTWAGSHSMR YFYTTMSRPG RGEPRFISVG YVDDTQFVRF DSDDASPREE PRAPWMEREG PEYWDRNTQI YKAQAQTDRV DLETLRGYYN QSEGGSHTIQ RMYGCEVGPD GRFLRGYLQD AYDGKDYITL NEDLRSWTAA DMAAQITQRK WEAAREAERL RAYMEGTCVE WLRRHLENGK ETLQRTDPPK THMTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPG GDGTFQKWAA VVVPSGKEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLLGA VITGAVVAAM MWRKKSSGRK GGSYSQAASS DSAQGSDVSL TA // ID A0A024RCL3_HUMAN Unreviewed; 235 AA. AC A0A024RCL3; DT 09-JUL-2014, integrated into UniProtKB/TrEMBL. DT 09-JUL-2014, sequence version 1. DT 12-SEP-2018, entry version 37. DE SubName: Full=MHC class I polypeptide-related sequence A, isoform CRA_a {ECO:0000313|EMBL:EAX03394.1}; GN Name=MICA {ECO:0000313|EMBL:EAX03394.1, GN ECO:0000313|Ensembl:ENSP00000480992}; GN ORFNames=hCG_2001511 {ECO:0000313|EMBL:EAX03394.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:EAX03394.1}; RN [1] {ECO:0000313|EMBL:EAX03394.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11181995; DOI=10.1126/science.1058040; RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., RA Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., RA Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G., RA Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., RA Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., RA Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., RA Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., RA Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., RA Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., RA Brandon R., Cargill M., Chandramouliswaran I., Charlab R., RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., RA Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., RA Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., RA Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., RA Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., RA Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., RA Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., RA Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., RA Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., RA Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., RA Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., RA Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., RA Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., RA Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., RA Kline L., Koduru S., Love A., Mann F., May D., McCawley S., RA McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., RA Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., RA Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., RA Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., RA Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., RA Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., RA Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., RA Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., RA Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., RA Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., RA Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., RA Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., RA Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., RA Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., RA McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., RA Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.; RT "The sequence of the human genome."; RL Science 291:1304-1351(2001). RN [2] {ECO:0000313|Ensembl:ENSP00000480992, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [3] {ECO:0000313|EMBL:EAX03394.1} RP NUCLEOTIDE SEQUENCE. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSP00000482382} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. RN [5] {ECO:0000313|Ensembl:ENSP00000480992} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL645933; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL669854; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX005439; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX119958; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471081; EAX03392.1; -; Genomic_DNA. DR EMBL; CH471081; EAX03394.1; -; Genomic_DNA. DR EMBL; CH471081; EAX03395.1; -; Genomic_DNA. DR RefSeq; NP_001276081.1; NM_001289152.1. DR RefSeq; NP_001276082.1; NM_001289153.1. DR UniGene; Hs.130838; -. DR SMR; A0A024RCL3; -. DR PRIDE; A0A024RCL3; -. DR Ensembl; ENST00000614103; ENSP00000480992; ENSG00000233051. DR Ensembl; ENST00000616296; ENSP00000482382; ENSG00000204520. DR Ensembl; ENST00000616968; ENSP00000482763; ENSG00000231225. DR GeneID; 100507436; -. DR UCSC; uc021yuo.3; human. DR CTD; 100507436; -. DR EuPathDB; HostDB:ENSG00000204520.12; -. DR HGNC; HGNC:7090; MICA. DR OpenTargets; ENSG00000204520; -. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR ChiTaRS; MICA; human. DR GenomeRNAi; 100507436; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204520; Expressed in 204 organ(s), highest expression level in ectocervix. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A024RCL3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 110 199 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 235 AA; 27084 MW; 13DC02245C724972 CRC64; MTLAHIKDQK EGLHSLQEIR VCEIHEDNST RSSQHFYYDG ELFLSQNLET EEWTVPQSSR AQTLAMNVRN FLKEDAMKTK THYHAMHADC LQELRRYLES GVVLRRTVPP MVNVTRSEAS EGNITVTCRA SSFYPRNIIL TWRQDGVSLS HDTQQWGDVL PDGNGTYQTW VATRICRGEE QRFTCYMEHS GNHSTHPVPS GKVLVLQSHW QTFHVSAVAA GCCYFCYYYF LCPLL // ID A0A087X7T2_POEFO Unreviewed; 367 AA. AC A0A087X7T2; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 23. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000001835}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000001835, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000001835, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000001835}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000001835} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010094; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_007564358.1; XM_007564296.2. DR Ensembl; ENSPFOT00000001838; ENSPFOP00000001835; ENSPFOG00000001963. DR GeneID; 107832861; -. DR GeneTree; ENSGT00740000114936; -. DR OMA; SALTKTW; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 367 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001832467. FT TRANSMEM 311 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 276 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 367 AA; 41622 MW; 8EB73D4498B8B1C2 CRC64; MTTLILLLLS GIPAALTVTH SLRYFYTASS GVPSFPSYVS VGFVNDVQIS YCDSNINKNI PKQDWMNNVS SEHPNYWEEE TLTCREKQKI FKKNINIAKQ RFNHTGGVHV FQQMYGCDWD DETGEVRGYD QIGYDGEDLI ILDPWTHQWI APKPQADITI QKWDHDGDAL ELEKSYLTQT CAEWLQKYVN YGRSSMMRTD LPSVSFLQKS PSSVVSCLAT GFYPNGAEMF WRKDGEEIHW GVGKGEILPN NDGTFQMSVY IDLSSVPPED WPKYECVFQL SGVNADVIHR PEKTRILTNK SANTGYVKIP VGALATLGVI SVIGLIGLVG IFLYKKYKAK RKLPNEDFEH QYLKAANSAF SQVPRFR // ID A0A087X820_POEFO Unreviewed; 386 AA. AC A0A087X820; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 2. DT 28-MAR-2018, entry version 23. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000001923}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000001923, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000001923, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000001923}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000001923} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010094; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AYCK01010095; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000001927; ENSPFOP00000001923; ENSPFOG00000001994. DR GeneTree; ENSGT00740000114936; -. DR OMA; RITQRFY; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 300 324 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 386 AA; 43287 MW; 38AE0F28DE5D916A CRC64; LNPLHFICLC ELTCSTVTHS LKYFYTASSG IKNFPEFVTV GMVDEVPVSY YDSVIRKEIP KQDWLAKNEG PEYWESNTQI SIGSEQSFKA DIGIIKQRFN QTGGVHVVQV MYGCEWDDET QKVTGYRQFG YDGEDFLTLN TETNTWIAPQ PQAVLTTNKW NNNRALLESD KNYLNQICPE WLKKYVGYGR SSLMRTERPS VSVLQKSSSS PISCFATGFY PNRAEMFWRK DGEEIHDGVE KGEIVPNNDG TFQMSVHIDL SSVPTEDRNK YECVFQLSGD KEDVTNRLEK TRILTNESNI ILIIPVVAAV AVLGLIAVIG FIVYKKKNVS EEKKTSTSSS ETSTSSSETL ASNSETSSLT SEGSDDSKGS SSSDKPLLRR QQNPNK // ID A0A087X890_POEFO Unreviewed; 277 AA. AC A0A087X890; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 2. DT 28-MAR-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000001993}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000001993, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000001993, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000001993}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000001993} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01029465; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AYCK01029482; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000001997; ENSPFOP00000001993; ENSPFOG00000002148. DR Ensembl; ENSPFOT00000005810; ENSPFOP00000005801; ENSPFOG00000005918. DR GeneTree; ENSGT00740000114936; -. DR OMA; THECPEW; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 277 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014013296. FT TRANSMEM 214 239 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 113 199 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 277 AA; 31571 MW; 84B8EA73B2B99652 CRC64; MRNKPNLFSS SFYLCLSGVH VVQVMYGCEW DDETQKVTGY RQFGYDGEDF LTLNTETNTW IAPQPQAVLT TNKWNNNRAL LESDKNYLNQ ICPEWLKKYV GYGRSSLMRT ERPSVSVLQK SSSSPISCFA TGFYPNRAEM FWRKDGEEIH DGVEKGEIVP NNDGTFQMSV HIDLSSVPTE DRNKYECVFQ LSGDKEDVTN RLEKTRILTN ESNISIVIIL VVAAVAVLGL IAVIGFIVYK KMNAKRPPSR KYSPNFLKSP LLEDIQFYSL LKTETQS // ID A0A087X950_POEFO Unreviewed; 371 AA. AC A0A087X950; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 2. DT 28-MAR-2018, entry version 21. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000002303}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000002303, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000002303, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000002303}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000002303} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010094; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AYCK01010095; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000002307; ENSPFOP00000002303; ENSPFOG00000001994. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 371 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001832521. FT TRANSMEM 312 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 203 277 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 371 AA; 42245 MW; E027A5457C16872C CRC64; TDKMLNFVLL LLLGIHSSAA VSHSLKYFYT ASTKVPGFPE FVVVALVDDV QIAYYDSVIK RAEPKQDWMR EITDQEYWER ETGNFLGNQQ IFKANIEILK MRFNQTGGVH IVQHMYGCEW DDETAEVKGY DQFGYDGEDF ITLSLETKSW IAPTRQAVIT KQKWDNNVAF VKNEESYLTQ ICPEWLQKYV NYGRSSLMKT ELPSVSLLQR FSSSPVSCHA TGFYPDTAEM SWRKDGEEIH DGVEKGEILS NHDGTFQMSV NIYLESVPPE DWTKYECVFL LSGVERDVIR LEKTRIRTNE LKSVSTVNRN TTIIPVVVVF LCLIGLIGFF LYKKNKGSQD TKTSPSCPEA SSLTSKSSDD SQGRTSDKSL L // ID A0A087X960_POEFO Unreviewed; 358 AA. AC A0A087X960; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 23. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000002313}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000002313, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000002313, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000002313}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000002313} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010098; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AYCK01010099; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_007564354.1; XM_007564292.2. DR Ensembl; ENSPFOT00000002317; ENSPFOP00000002313; ENSPFOG00000002477. DR GeneID; 103146387; -. DR GeneTree; ENSGT00740000114936; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 358 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001832517. FT TRANSMEM 307 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 279 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 358 AA; 40957 MW; 9616034D88C775A7 CRC64; MAAVRILILL ILLELKETEP VIHSLRYFYS ASSGLPDVPS YMSAGFLDDV QISYCDSRNN RNIPKQDWMN NVSSDNPHYW EEETLTCLAK QETLKENIEI AKLRLNQTGG VHVYQHMYGC DWDNETGEVK GYDQIGYDGE DFIALDLNTS LWIAAKPEAV LTKHKWDKNK YALQYEKFYF LKVCVEWLKK YERSGRRFLM KTVLPSVFLL QKTFSSPVSC LATGFYPNKA EIFWRKGEKQ IHKGVETGEI LPNNDGTFQM SAHIDLSSVG PEDWSKYECV FQLSGVNSII HRLEKTRILT NKSNTNILII PVVVAVTVLG LIAVIGFIVY KKKMNAKRPP SPVVYCQPPE ETQFLPHA // ID A0A087X987_POEFO Unreviewed; 366 AA. AC A0A087X987; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 23. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000002340}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000002340, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000002340, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000002340}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000002340} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010099; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_007564361.1; XM_007564299.2. DR Ensembl; ENSPFOT00000002344; ENSPFOP00000002340; ENSPFOG00000002483. DR GeneID; 103146392; -. DR GeneTree; ENSGT00740000114936; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001832533. FT TRANSMEM 308 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 276 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 42327 MW; F3893EDBDFFE9739 CRC64; MLVFVFLFLL DLRNVVGVTH SLRYFYTASS GIPNFPSYVS VGFVDDVQIS YCDSRKNDNI PKQEWMNDLR SEYPNYWEEE TKTCRAKQRT FKKNLEIAKQ RYNQSRGVPI FQQMYGCEWD DETGKVKGYD QFGYDGEDFI ALDLEGQSWI APKPQAFNTK QNWENNRVVQ ELEKIYLTHT CVEWLMTYVS YGRSSLTKTD LPSVSFLQKN SSSPVCCHAT GFYPNRAEMF WRKDGKEIHD GVVKEEILPN NDGTFQMSIY VNLSFVPSDD WAKYECVFQF SGFKENVVIR LERRKIRTME VNSTTSPIAV IVAVMIVALV IAVTAFLCQR KKNVTQYSTT ETSSSTSQDS HPSICCFRLR PGDMTY // ID A0A087XDS4_POEFO Unreviewed; 340 AA. AC A0A087XDS4; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 2. DT 28-MAR-2018, entry version 22. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000003927}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000003927, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000003927, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000003927}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000003927} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01012830; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AYCK01012831; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000003935; ENSPFOP00000003927; ENSPFOG00000004058. DR GeneTree; ENSGT00740000114936; -. DR OMA; SCEVIHE; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 340 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001832748. FT TRANSMEM 320 339 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 303 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 39176 MW; 879CDEB51F4A9C32 CRC64; MSLLAVLVLL GTGITVDSEK HSLTYIYTAF SKPVNLPGLH EFTAMGLLDN NMIDYYDSEH QVKVPKQDWM EKHLEPEYWE KGTQSRKSKQ QWFKVNIDIL MKRMRQNDND THILQWMHGC EGETQPDGSL KFVRGMDMYN YDGSDFLSFD DNHQVWVAPI HAAEETKRKW DEVQVLKEYT KGYLEKECME WMSKFRGFGK EKIEKASPPE VYLFTRKVNI EQNIILTCLA TGFYPGEIIL NIKRNGRVLT KEDGLVTSGY RPNHDHTFQR RDHVEILKSD VSAYICEVEH LASKSSVFQN KWSGHDFENP FVEDKGNTNV IIAASASIVI VVVAVAVTLV // ID A0A087XEG3_POEFO Unreviewed; 351 AA. AC A0A087XEG3; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 2. DT 28-MAR-2018, entry version 22. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000004166}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000004166, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000004166, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000004166}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000004166} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01012831; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000004174; ENSPFOP00000004166; ENSPFOG00000004282. DR GeneTree; ENSGT00740000114936; -. DR OMA; GYCQEAY; -. DR OrthoDB; EOG091G0BBK; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 351 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001832785. FT TRANSMEM 326 348 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 213 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 351 AA; 40641 MW; 6EE96339A46EEA08 CRC64; LVTFVLVTQY IVLLNLEFFC LTEKHSLTYI YTAFSKPVNL PGLHEFTAMG LLDNNMIDYY DSEHQVKVPK QDWMAKHLEP EYWDKGTQSR KSKQQWFKVN IDILMKRMRQ NNTDTHILQW MHGCEGETQP DGTMKFVRGM DMYNYDGSDF LSFDDNHQVW VAPIHAAEET KRKWDEVQVL KEYTKGYLEK ECMEWMAKFR DFGKDQLLKA SPPTVHLFTR KAKSETNTIL TCLATGFLPK DITMNIKRNG RVLTLEDGLV TTGVRPNNDN TFQKRDHVEI LKSDVSVYTC EVNHRASKMH VEEKWGYKQN VCTKLTKLRD NGNMPIIIGG AVAILIVIAA IGGTLIFLKK K // ID A0A087XEL9_POEFO Unreviewed; 349 AA. AC A0A087XEL9; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 20. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000004222}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000004222, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000004222, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000004222}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000004222} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01012831; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000004230; ENSPFOP00000004222; ENSPFOG00000004327. DR GeneTree; ENSGT00740000114936; -. DR OMA; RMFGCEI; -. DR OrthoDB; EOG091G0BBK; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 321 344 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 216 305 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 349 AA; 40839 MW; A546BDE7470537A7 CRC64; YSSAHKAAAF AVLSFYKLFP TYLRTEKHSL TYIYTAFSKP VNLPGLHEFT AMGLLDNRMI DYYDSENQVK VPKEDWMEKH LEPEYWEKGT QSRKSKQQWF KVNIDILMKR MRQNNNDTHI LQWMHGCEGE TQPDGSLKFV RGMDMYNYDG SDFLSFDDNH QVWVAPIHAA EETKRKWDEV QVLKEYTKGY LEKECMEWMT KFRGFGEEQL LNAKRPEVHL FTRKAKADTN TILTCLATGF YPKDIILQIK RNGRILTKED GIQTSGVLPN EDDTFQRKDH VEILKSDAAA YTCEVIHPAS HMKVEKKWDH NCNEDEQRPN IIIFVAVSML LFVVGGVLVF LFGYKKMRC // ID A0A087XK79_POEFO Unreviewed; 364 AA. AC A0A087XK79; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 20. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000006182}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000006182, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000006182, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000006182}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000006182} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010109; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000006192; ENSPFOP00000006182; ENSPFOG00000006289. DR GeneTree; ENSGT00740000114936; -. DR OMA; TWITANQ; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001833050. FT TRANSMEM 314 339 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 274 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 41599 MW; A145A895792D3D18 CRC64; MNMLFLLLLC ASSSPEKHSL TVLVTASSGL PHFPDFIITT QVDKLPTSYC DSNKNIRANP KYGQKLMNIE SQIADWYIEQ CFEIMSDYLK VKMRILKDLN QSEAVHILQV IIGCEWEEKT KETTSFLQFG YNGADFIKFD PNKLTWIPQT PQAVSIKPKW EADESAYHLK HKDFLNHICP DWLKKYMGDN QVPLQSTVLP SVFLLQTSPD SPVSCFATGF YPNKAAMFWR KDGEEIQDGV DKTEILCNQD NTFQMRTDIN VSSVHPEDWE RHECVFHLVD VRDDVVSRLE KEKIQTNWGK RQRHNDEGNP EKPIGLIVSI TAAVVFLVII VAAVGFAVIK NRKGKETSTP INSIELSERL NQET // ID A0A087XK82_POEFO Unreviewed; 359 AA. AC A0A087XK82; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 22. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000006185}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000006185, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000006185, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000006185}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000006185} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010109; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_016533027.1; XM_016677541.1. DR Ensembl; ENSPFOT00000006195; ENSPFOP00000006185; ENSPFOG00000006305. DR GeneID; 103146412; -. DR GeneTree; ENSGT00740000114936; -. DR OMA; NASHFND; -. DR OrthoDB; EOG091G0BS4; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 359 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001833060. FT TRANSMEM 306 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 175 277 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 40436 MW; F97D3E866B563D84 CRC64; MRLYTNKIVI LLLLCQASSS VKNSLTFSGT ILTGIKDLPN MFTTVIDDIQ VDYYDGNGVR KQSSILWKNI SDFYPNMAFS EEALSSLDNL LTSYLNKTAN LNPTEAVHVL QCMTGCKLDK TSAEVVIFQQ CGYNGEDFMK ADFNNLTWVA QSPLAENLTQ GLNIYRRPFL SLTCPKMLNE FVNRSALQRE DLTSVALLQK NSSSLVRCFA TGFYPNSAEM FWRRDGVEIQ NDEKPSEILP NHDDTYQMSV DLNVSAIASE DWKRYDCVFK LGNKTIATRL KKEINITEDA SDPVSPSSSS KFPLDLAIGL VVGLILLCFC ITGLFLWKNS INASHFNDRP SYPNYPTTIR NCQHHCDLE // ID A0A087XK86_POEFO Unreviewed; 344 AA. AC A0A087XK86; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000006189}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000006189, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000006189, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000006189}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000006189} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010109; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_007564381.1; XM_007564319.2. DR Ensembl; ENSPFOT00000006199; ENSPFOP00000006189; ENSPFOG00000006308. DR GeneID; 103146410; -. DR GeneTree; ENSGT00740000114936; -. DR OMA; DWARYDC; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 15 {ECO:0000256|SAM:SignalP}. FT CHAIN 16 344 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013311607. FT TRANSMEM 305 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 273 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 344 AA; 39820 MW; 58F3AE53EFFBB350 CRC64; MKIVILLMFC HTTAAVMHVM KIDFTGSSGL TEFPAFEAIT EVDDIQVVYC NAKIVEANQD WMQEIFTDHP DQFQWAKDHC YVNSPPFFRY NVDLIMNHFN QSEGIHIFQS SSGCELNMET KELTGFMKYG YDGEDFLEFD LKGRKWIALR KEALFLKQRW DLDILNINLF VDLLTNQCYL WLSESLIAGN RTLFRTDYPS VSLLQKTPSS PVRCHATGFY PKSFLMFWRK DGEEIHEGVH PGDILNNEDS TFQYRVDLDI SSVPPEDWAR YDCVFQFIGA EDKILIKLDK EVIETNQDES SQIRIIIIAV ISVVIAIIII ALAFTAYKRR NERPLTPDSE NMSL // ID A0A087XK88_POEFO Unreviewed; 361 AA. AC A0A087XK88; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 20. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000006191}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000006191, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000006191, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000006191}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000006191} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010109; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000006201; ENSPFOP00000006191; ENSPFOG00000006309. DR GeneTree; ENSGT00740000114936; -. DR OMA; NCQHNFE; -. DR OrthoDB; EOG091G0BU8; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 361 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001833077. FT TRANSMEM 308 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 182 283 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 361 AA; 40732 MW; 062C99C557195436 CRC64; MCLYTNKIVI LLLLCQASSS VKNSLTIFAI ISTGIRDLPN LFTTVIDDIQ VDYYDGNGIR KQSSILWKNI SDSYHSTIFS KEVLTYVDLG FTVYLNKLGT LNPDEAVHVL QCMSSCELDE TSVGVVTFQQ CGYNGDNFMK LDSKNMTWVA QHPLAESLKP LWDSAQEQLN NITLFLTFIC PPMLKEFVTL SALQREDFTS VALLQKTPSS PVRCFVTGFY PNTAEMFWRR DGEKIQNDEE PSEILPNHND TYQMSVDLNV SSIASEDWKR YDCVFKLGNK TITTRLEKAA ISTNWDPVSS SSEFPLDLAI GLVVGLILLC FCITGLFLWK NVNNASKYPD TSSYPTYPGI IQNCQHNFEI Q // ID A0A087XKE9_POEFO Unreviewed; 346 AA. AC A0A087XKE9; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 2. DT 28-MAR-2018, entry version 23. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000006252}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000006252, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000006252, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000006252}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000006252} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010111; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000006262; ENSPFOP00000006252; ENSPFOG00000006312. DR GeneTree; ENSGT00740000114936; -. DR OMA; NTENPEY; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 308 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 346 AA; 39616 MW; FF14555C91687A7E CRC64; LKSLMSLFSK MTGKNNISKI THSYQYKFTA AYGVQDFPEF VGAATVDDVQ VGYCDSNIKT VKPKQDWMKK LFERNPEHLE WYSQKCLGNQ HVFRANIDIL KRRLNLTEEG PHILQRMNGC EWDDETGEVI GFNQYGFNGE DFLALDLKTL TWIAPKSQAV LTKLLWDDEK ARLEHNKHYC IYKCPDWLKN YIRHGKSFLQ RTKNPSISLL QRTPSSVVSC HATGFFPGRA EMFWTKDGEE IHEDVEKGEI LFNNDGTFQM SVEFNVSSVP PDGWRRYDCV FQLSGVGDDI KITLDKSVIR TNSYPPEFPA ALVAGIAGGF LLLLVIAVIV LWLKKRTGFR HVDGED // ID A0A087XKF3_POEFO Unreviewed; 340 AA. AC A0A087XKF3; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000006256}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000006256, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000006256, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000006256}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000006256} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010111; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AYCK01010112; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_007564458.1; XM_007564396.2. DR Ensembl; ENSPFOT00000006266; ENSPFOP00000006256; ENSPFOG00000006366. DR GeneID; 103146462; -. DR GeneTree; ENSGT00740000114936; -. DR OMA; NETEKTH; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 15 {ECO:0000256|SAM:SignalP}. FT CHAIN 16 340 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013062512. FT TRANSMEM 303 325 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 197 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 38728 MW; 82DB4C684C8F6730 CRC64; MKIFALFFIC HVVSPAQHLI SSIIFAISGA PDVPEFVTVG ILDDIPVGYC DSNKIQLEPR TTWMKNVFRD YPNHQSWLSE KCKKNNIEFI STVRSLMERF NQSEGVHIFQ RTIGCSWDDN SETISAFVQF GYDGEDLISF DLGTLTWIAP IPHTVITKLN WDTNGQEKFF WTNTFKDDCR HLFNLYLGYG NSSLQTPVLP SLFLLQKTPT SPVSCHATGF YPNKAVIFWS RDGEKIHENV DPFESLPNND GTFQMTVNLN ILSLTSEDWS RINCIFQFSN FQENISFALD KAIIKTNYVS AGGFLGIFVV PATGASFLLL AVCVFQTKIR KWLYERQQTT // ID A0A087XLF6_POEFO Unreviewed; 357 AA. AC A0A087XLF6; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 2. DT 28-MAR-2018, entry version 21. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000006609}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000006609, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000006609, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000006609}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000006609} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010112; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000006621; ENSPFOP00000006609; ENSPFOG00000006404. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 357 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001833138. FT TRANSMEM 310 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 204 278 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 357 AA; 40948 MW; 059202E641601CCC CRC64; QIAIMNCFGL LLLFHVASSV KHSLRYFLTA THGVHDFPEF FGAATVDEVQ VGYCDSNIKT AKPKQDWMMK LIERNPEHLE WYSQKCLGSQ HVFRANIDIL KQRLNLTKGP HILQRMNGCE WDDETGEVIG FNQYGYNGED FLALDLKTLT WTAPKSQAVL TKLIWDGEKA RLEHNKNYYI YKCPDWLKNY IRHGKSFLQR TVHPSVSLLQ KTPSSVVTCH ATGFYPERAT MFWRKDGQEL HEGVEKGEIL PNNDGTFQMS VDLNISSVTA EDWRRYDCIF LFAGLKDSIT TRLDRTMIRT NQDESSQIRI VIAVISVVIA IIIIAVAFTA YKKRNGKSTL KLDSSSNLIK YKLNKIN // ID A0A087YR83_POEFO Unreviewed; 57 AA. AC A0A087YR83; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 15. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000020536}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000020536, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000020536, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000020536}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000020536} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010100; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000020560; ENSPFOP00000020536; ENSPFOG00000020410. DR GeneTree; ENSGT00910000145114; -. DR OMA; QITHYDS; -. DR OrthoDB; EOG091G1TC5; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}. FT DOMAIN 1 55 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 57 AA; 6612 MW; A34E34C5A42C7096 CRC64; VGYVDGVQIT HYDSNTGKTV PKQDWMRDNT DQQYWERQTG IGQGHQQTFK NNIEVAK // ID A0A091CPP3_FUKDA Unreviewed; 739 AA. AC A0A091CPP3; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 22. DE SubName: Full=Spliceosome RNA helicase DDX39B {ECO:0000313|EMBL:KFO21034.1}; GN ORFNames=H920_17538 {ECO:0000313|EMBL:KFO21034.1}; OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Fukomys. OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO21034.1, ECO:0000313|Proteomes:UP000028990}; RN [1] {ECO:0000313|EMBL:KFO21034.1, ECO:0000313|Proteomes:UP000028990} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC TISSUE=Liver {ECO:0000313|EMBL:KFO21034.1}; RA Gladyshev V.N., Fang X.; RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of RT African mole rats."; RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KN124473; KFO21034.1; -; Genomic_DNA. DR Proteomes; UP000028990; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW. DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro. DR CDD; cd00079; HELICc; 1. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom. DR InterPro; IPR014001; Helicase_ATP-bd. DR InterPro; IPR001650; Helicase_C. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00270; DEAD; 1. DR Pfam; PF00271; Helicase_C; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00487; DEXDc; 1. DR SMART; SM00490; HELICc; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1. DR PROSITE; PS51194; HELICASE_CTER; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. DR PROSITE; PS51195; Q_MOTIF; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000313|EMBL:KFO21034.1}; KW Complete proteome {ECO:0000313|Proteomes:UP000028990}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Helicase {ECO:0000313|EMBL:KFO21034.1}; KW Hydrolase {ECO:0000313|EMBL:KFO21034.1}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000313|EMBL:KFO21034.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000028990}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 698 720 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 45 73 Q_MOTIF. {ECO:0000259|PROSITE:PS51195}. FT DOMAIN 76 249 Helicase ATP-binding. FT {ECO:0000259|PROSITE:PS51192}. FT DOMAIN 261 422 Helicase C-terminal. FT {ECO:0000259|PROSITE:PS51194}. FT DOMAIN 595 683 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT MOTIF 45 73 Q motif. {ECO:0000256|PROSITE- FT ProRule:PRU00552}. SQ SEQUENCE 739 AA; 84134 MW; F423BA69C6BE5DBD CRC64; MAENDVDNEL LDYEDDEVET AAGGDGAEAP AKKDVKGSYV SIHSSGFRDF LLKPELLRAI VDCGFEHPSE VQHECIPQAI LGMDVLCQAK SGMGKTAVFV LATLQQLEPV TGQVSVLVMC HTRELAFQIS KEYERFSKYM PNVKVAVFFG GLSIKKDEEV LKKNCPHIVV GTPGRILALA RNKSLNLKHI KHFILDECDK MLEQLDMRRD VQEIFRMTPH EKQVMMFSAT LGKEIRPVCR KFMQDPMEIF VDDETKLTLH GLQQYYVKLK DNEKNRKLFD LLDVLEFNQV VIFVKSVQRC IALAQLLVEQ NFPAIAIHRG MPQEERLSRY QQFKDFQRRI LVATNLFGRG MDIERVNIAF NYDMPEDSDT YLHRVARAGR FGTKGLAITF VSDENDAKIL NDVQDRFEVN ISELPDEIDI SSYSSYSLRY FHIAVSRPGR GEPRFMTLGY VDDTQFMRFD SDALDPREEP RAVWMEEDQA YWDRSTQIHK DTAQIYRVSL RNLRGYYNQT EDVGSDGRLL RGYEQHAYDG ADYISLAEDL SSWVAADTAA LITQRKWVEA GAAESTRAYL EGTCVEWLRR HLENGNETLQ RADPPETHVT RHPVSKEEVT LRCWALGFYP AEISLTWQRG GQDLTQDMEL VETRPAGDGT FQKWVAVAVP SGEEQHYTCR VQHEGLPEPR TLTWERPLPP TISRGVEVVV VIAALLGVLV IVAAVAVVMW RRKRAGSDRA QGSDSSLMT // ID A0A091CSZ9_FUKDA Unreviewed; 459 AA. AC A0A091CSZ9; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 20-JUN-2018, entry version 20. DE SubName: Full=Patr class I histocompatibility antigen, A-126 alpha chain {ECO:0000313|EMBL:KFO21033.1}; GN ORFNames=H920_17537 {ECO:0000313|EMBL:KFO21033.1}; OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Fukomys. OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO21033.1, ECO:0000313|Proteomes:UP000028990}; RN [1] {ECO:0000313|EMBL:KFO21033.1, ECO:0000313|Proteomes:UP000028990} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC TISSUE=Liver {ECO:0000313|EMBL:KFO21033.1}; RA Gladyshev V.N., Fang X.; RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of RT African mole rats."; RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KN124473; KFO21033.1; -; Genomic_DNA. DR Ensembl; ENSFDAT00000013847; ENSFDAP00000018131; ENSFDAG00000010062. DR Proteomes; UP000028990; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 2. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS00290; IG_MHC; 2. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028990}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028990}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 459 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001872506. FT TRANSMEM 300 322 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 432 452 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 197 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 330 418 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 459 AA; 51683 MW; 256B18C3402F1509 CRC64; MGVMAPRTLL LLLSGTLVLP ETWAGSHSLR YFDIAVSRPG RGEPRFMIVG YVDDTQFVRF DSDALDPRVE PRAAWMEKVD QAYWDRNTQI AKNTAQNYRV NLRTLRGYYN QTEDVGSDGR LLRGYSQWGY DGADYISLAE DLSSWVAADT AALITQRKWV EAEYAERLRA YLEGTCVEWL RRHLENGKET LQRAEPPETH VSHHPVSKEE VTLRCWALGF YPAEISLTWQ RGGQDLTQDM ELVETRPAGD GTFQKWAAVA VPSGEEQHYT CRVQHEGLPE PRTLMWERPL PPTISRGVEV VVVIAALLGV LVIVAAVAVV MWRRKRAASP ATHVTHHPVS KEEVTLRCWA LGFYPAEISL TWQRGGQDLT QDMELVETRP AGDGTFQKWA AVAVPSGEEQ HYTCRVQHEG LPEPHTLTWE PPPHPTIPNK GAITASILLV AVVTGAVIVV IWRRRVGKR // ID A0A091D3H6_FUKDA Unreviewed; 551 AA. AC A0A091D3H6; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 20-JUN-2018, entry version 20. DE SubName: Full=Patr class I histocompatibility antigen, A-126 alpha chain {ECO:0000313|EMBL:KFO25073.1}; GN ORFNames=H920_13525 {ECO:0000313|EMBL:KFO25073.1}; OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Fukomys. OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO25073.1, ECO:0000313|Proteomes:UP000028990}; RN [1] {ECO:0000313|EMBL:KFO25073.1, ECO:0000313|Proteomes:UP000028990} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC TISSUE=Liver {ECO:0000313|EMBL:KFO25073.1}; RA Gladyshev V.N., Fang X.; RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of RT African mole rats."; RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KN123415; KFO25073.1; -; Genomic_DNA. DR Ensembl; ENSFDAT00000015529; ENSFDAP00000001593; ENSFDAG00000011515. DR Proteomes; UP000028990; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 2. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028990}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028990}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 551 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001871664. FT TRANSMEM 309 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 551 AA; 61847 MW; 0FCDBB2C54195227 CRC64; MAPRTLLLLL SGALVLPETW AGSHSLRYFD IAVSRPGRGE PRFMSVGYVD DTQFVRFDSD ALDPRVEPRA AWMEKVDQAY WDRETKRAED TAEAFRVNLR TLRGYYNQSE DGSHTLQWTS GCEMGSNGHL LRGYAQFAYD GEDYLYLNED LNSWTAMDTA AQISRTKSEA AGETEEQRAY VEGECMEWLG RYLEAGKETL QRSEPPETHV TRHPVSKEEV TLRCWALGFY PAEISLTWQR GGQDLTQDTE LVETRPAGDG TFQKWAAVAV PSGEEQHYMC RVQHEGLPEP RTLMWERPLP PTISRGVEVV VVIAALLGVL VIVAAVAVVM WRRKRADHRS APPLGCPAVC AIGRFGGTWP FQLEAKQHHL ENETSAVHLH CPECMAPLNA LHGSAFALGE EEPEAEAGGL LTPLTLSSPR SRVRNPADLG TTADRLAYAP RLSGLVPENP LSDQGHLFGG RRRGALLWLL LSFAQTAHPR SRPLQYFYWT VSEPGHTVPR FTASGFVDNQ PFIRYDSEVV EAKPLVPWLK EDKSYFDNET KIFASRMKVF Q // ID A0A091D4D3_FUKDA Unreviewed; 261 AA. AC A0A091D4D3; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-FEB-2018, entry version 15. DE SubName: Full=Patr class I histocompatibility antigen, A-2 alpha chain {ECO:0000313|EMBL:KFO25095.1}; GN ORFNames=H920_13547 {ECO:0000313|EMBL:KFO25095.1}; OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Fukomys. OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO25095.1, ECO:0000313|Proteomes:UP000028990}; RN [1] {ECO:0000313|EMBL:KFO25095.1, ECO:0000313|Proteomes:UP000028990} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC TISSUE=Liver {ECO:0000313|EMBL:KFO25095.1}; RA Gladyshev V.N., Fang X.; RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of RT African mole rats."; RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KN123415; KFO25095.1; -; Genomic_DNA. DR Proteomes; UP000028990; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028990}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028990}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 261 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001871685. FT TRANSMEM 220 242 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 117 205 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 261 AA; 29447 MW; 094B7E9CFF1CF601 CRC64; MGVMAPRTLL LLLSGTLVLP ETWAGSHSLR YFDIGVSRPG HGEPRFMIVG YVDDTQFVRF DSDALDPRME PRAAWMEKVD QAYWDRETQN AKNTAQIYRV DLRNLRGYYN QTEDEPPETH VSHHPVSKEE VTLRCWALGF YPAEISLTWQ RGGQDLTQDM ELVETRPAGD GTFQKWAAVA VPSGEEQHYT CRVQHEGLPE PRTLMWERPL PPTISRGVEV VVVIAALLGV LVIVAAVAVV MWRRKRAGRD CAQGSDSSLM T // ID A0A091D7L5_FUKDA Unreviewed; 604 AA. AC A0A091D7L5; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 22-NOV-2017, entry version 22. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFO26210.1}; GN ORFNames=H920_12367 {ECO:0000313|EMBL:KFO26210.1}; OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Fukomys. OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO26210.1, ECO:0000313|Proteomes:UP000028990}; RN [1] {ECO:0000313|EMBL:KFO26210.1, ECO:0000313|Proteomes:UP000028990} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC TISSUE=Liver {ECO:0000313|EMBL:KFO26210.1}; RA Gladyshev V.N., Fang X.; RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of RT African mole rats."; RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KN123228; KFO26210.1; -; Genomic_DNA. DR Proteomes; UP000028990; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR018247; EF_Hand_1_Ca_BS. DR InterPro; IPR002048; EF_hand_dom. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF13202; EF-hand_5; 2. DR Pfam; PF13833; EF-hand_8; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00054; EFh; 3. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF47473; SSF47473; 2. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS00018; EF_HAND_1; 4. DR PROSITE; PS50222; EF_HAND_2; 6. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Calcium {ECO:0000256|PROSITE-ProRule:PRU00448}; KW Complete proteome {ECO:0000313|Proteomes:UP000028990}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000028990}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT DOMAIN 214 301 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 351 388 EF-hand. {ECO:0000259|PROSITE:PS50222}. FT DOMAIN 389 424 EF-hand. {ECO:0000259|PROSITE:PS50222}. FT DOMAIN 439 474 EF-hand. {ECO:0000259|PROSITE:PS50222}. FT DOMAIN 476 511 EF-hand. {ECO:0000259|PROSITE:PS50222}. FT DOMAIN 530 552 EF-hand. {ECO:0000259|PROSITE:PS50222}. FT DOMAIN 553 588 EF-hand. {ECO:0000259|PROSITE:PS50222}. FT CA_BIND 402 413 {ECO:0000256|PROSITE-ProRule:PRU00448}. FT CA_BIND 489 500 {ECO:0000256|PROSITE-ProRule:PRU00448}. FT CA_BIND 530 541 {ECO:0000256|PROSITE-ProRule:PRU00448}. FT CA_BIND 566 577 {ECO:0000256|PROSITE-ProRule:PRU00448}. SQ SEQUENCE 604 AA; 68599 MW; A962E8E8196A8281 CRC64; MVSRRRQGEQ VPLLTPFTLC LVPLAEPRVP KALTETESHL SLLYHLTAVS SPASGSPAFW VSGWLGPQQY LSYSSLRKEA EPCGAWVWEN QVSWYWEKET TDLRNKERLF LDALRALEGE GPYTLQGLLG CELSPDNASV PTALFALNGE DFMQFHPRNG SWTGDWPEAL TISTQWQQQA EAVARERTFL LSSCPQRLLD HLERGRMNLE WKEPPSMRLK ARPGIAGFSE LTCSAFSFYP PELQLRFLRN GLAAGSGRGG FGPNGDGSFH AWSSLMVQRG DEHHYRCLVR HAGLPQPLLV ELGPHGQARV HQAAPLSDAA HDDAHGNFQY DHEAFLGREV AKEFDQLTPE ESQARLGRIV DRMDRAGDGD GWVSLAELRA WITHTQQRHI RDSVSAAWDT YDTDRDGRVG WEELRNATYG HYAPGEEFHD VEDAETYKKM LARDERRFRV ADQDGDSMAT REELTAFLHP EEFPHMRDIV IAETLEDLDK DKDGYVQVEE YIADLYSAEP GEEEPAWVQT ERQQFRDFRD LNKDGRLDGS EVGYWVLPPS QDQPLVEANH LLRESDQDKD GRLSKAEILG NWNMFVGSQA TNYGEDLTRH HDEL // ID A0A091DJQ5_FUKDA Unreviewed; 1550 AA. AC A0A091DJQ5; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 20. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFO30693.1}; GN ORFNames=H920_07933 {ECO:0000313|EMBL:KFO30693.1}; OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Fukomys. OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO30693.1, ECO:0000313|Proteomes:UP000028990}; RN [1] {ECO:0000313|EMBL:KFO30693.1, ECO:0000313|Proteomes:UP000028990} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC TISSUE=Liver {ECO:0000313|EMBL:KFO30693.1}; RA Gladyshev V.N., Fang X.; RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of RT African mole rats."; RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KN122390; KFO30693.1; -; Genomic_DNA. DR Proteomes; UP000028990; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR Gene3D; 1.10.150.40; -; 1. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR004122; BAF_prot. DR InterPro; IPR036617; BAF_sf. DR InterPro; IPR032756; DUF4685. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR001478; PDZ. DR InterPro; IPR036034; PDZ_sf. DR Pfam; PF02961; BAF; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF15737; DUF4685; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF00595; PDZ; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM01023; BAF; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF47798; SSF47798; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF50156; SSF50156; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. DR PROSITE; PS50106; PDZ; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028990}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028990}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 1494 1520 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1131 1201 PDZ. {ECO:0000259|PROSITE:PS50106}. FT DOMAIN 1400 1479 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 1550 AA; 169507 MW; 23BC3B633D6CAA89 CRC64; MTTSQKHRDF VAETMGEKPV RSLAGVGKVL GDLFLLLKYS TLPIQVLSRK PKTGSRTTSP MPVTSVEERN DPEPQPDNGL FSRPWPFPPP KPPRLYRMQL HGPSVLESKV RALKEKMTAG KQGVSPTTHE QSSPKKSTCQ RVKPGRDRIS EDSSLSESVV VPYVQNLPGG HLGSSVNKEE PMRNGGSRPL SSAPELECRN GQSPLPPEVV WLVPGRERDL PPGPDSSAES PSHGVSPGCP AEPGPCKIAC IPSLKKGRPD SLQDGLVTVG DLDSTSLIPE KAFVPRTAPL GTLWKARDLG TLGIGGNALS LTDQVERNRL LLQEMLKVSE QSSPKVAPPA WAPSWDRTAP ERPAGDVGWE SGIFLQDSEQ NRTFGPKPEA VLSTRHEEAK HLLQHSRMKA RTRPLRASHD IVPTIAPGSR DGRRSPALGP RTTFACGDSL QSGSPTAPSS GESSSGQWPK RGLSPSHVRF EDEPAYEAEF RHLKRLQQYQ HQVLSTVLQA AGQGPLRSKP DLADYMNQKV AMGTFHRLRE SQDRRGHAPL PPSGASERKF QACSHCPESQ RPDPGVLEEL QAACGVEGTL CVSHSSRGLS SPFQLLLAEP GLHTERLRET HAGETTTSPE EGDSALDSTD TSDGCRTDRE EAGTSLPNRA GRQTRGSNPR QRDSRPQGGL RWSRKAKTEL LCGLQAWRHS LGVDDMEVGD EVKEVAGHRP VGTQFLKEDA VPKPPPLESE MAFLGSQRQP GPGLGNNQAY PVDFRAPCKP PSSTTSSMKL APSRSGRADQ VTESHEYLET VHTSSLQQNH AHPTASNPTL QPATSPPPEG WISLRATSPV SHRNAGMAGP CRPGEQEEPV GIPLPLSPPR TVVLRTCGLS PPQTQPSIPQ VRHPLLGLSS NNRNSCIPVG QQEPWEMAVH RGREERDPCD QEPDPPLESS RDGGHQGPLG LADVATFNSV GITLTLTSEE PESCQEAEED LQRAESSSGR HMLSGQKKRS SIASTLGLKK LFSALGQTSR PKLGKSRSRS VEHLQPDAPG SASHTSAPKV KRAPSLQSFH LVSSSRQHQK AASFQNLHSL LSGRGNRSSL YLVEGPEYPS APGRLAKAPP RRALSVEDVG VPSLARTVGR VVAVFPDGTS LLQLQRSPAG TFGFRVGSGK GRRDSGLYVQ EMADLDTAKL YSGLLGVGDE ILEVNGAKVA GLGLAHIKEL LAHSESLKGQ ASRSSSHTAG THSLRYFRLG LSDPSHGVPE FVSVGYVDSY PITSYDSVTR RKEPRAPWMV ENLTPDHWDR YTQLLRGWQQ RFKEELRHLQ RHYNHSGFHT YQRMIGCELL EDGSTTGFLQ YAYDGQDFIV FNKDTLSWVA VDNVAHITKR AWEANQHELQ YQKNWLEKEC IAWLKRFLEY GKDTLQRTEP PLVRTNLQET LPGITTLFCR AHGFYPPEIS MMWMKNGEEI VQEVDYGDIL PSGDGTYQTW VSLELDPQSS DIYSCQVEHC GLQMVIQAPQ EWKIILLVTR VVPVAIGLAI VLAGVGILAW RRRRGDQNPV GVQASKNPPA RLMLCFTIPS // ID A0A091DUB3_FUKDA Unreviewed; 371 AA. AC A0A091DUB3; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 23. DE SubName: Full=Hereditary hemochromatosis protein like protein {ECO:0000313|EMBL:KFO33870.1}; GN ORFNames=H920_04864 {ECO:0000313|EMBL:KFO33870.1}; OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Fukomys. OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO33870.1, ECO:0000313|Proteomes:UP000028990}; RN [1] {ECO:0000313|EMBL:KFO33870.1, ECO:0000313|Proteomes:UP000028990} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC TISSUE=Liver {ECO:0000313|EMBL:KFO33870.1}; RA Gladyshev V.N., Fang X.; RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of RT African mole rats."; RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KN122054; KFO33870.1; -; Genomic_DNA. DR Proteomes; UP000028990; Unassembled WGS sequence. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028990}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028990}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 327 349 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 231 319 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 371 AA; 41831 MW; 8667FD4E9835E91C CRC64; MFSVCDKASG LFVGHGVVVP SPVSLPLCYC IEFVEGPGRP GLGPQRVPGS HTLHYLFMCA SEPDIGLPLF EALGYVDDQL FVSYNRESRR AEARAPWIGS RTSSRLWLQL SQSLKGWEHM FIVDFWTIMD NHNHNKEPHT LQVILGCKVQ EDNSTRGFWK YGYDGQDHLD FCPETLDWRA AEPAAHATKL EWEEHKIREK QIKAYLEKDC PEQLQRFLEL GRGVLDQSVP PSVKVTHHVA PAATMLQCQA LNFYPQNITM RWLKDKQPLD VKESGWKDVL PNGDGTYQGW VALSVPLGEE QRYTCQVEHA GLDQPLTATW EPSPSNALVI GITSGTTVCV IIFFTGILFR TLRKKQASRG AMRDYVLAGC E // ID A0A091E6X1_FUKDA Unreviewed; 115 AA. AC A0A091E6X1; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=Class I histocompatibility antigen, Gogo-C*0203 alpha chain {ECO:0000313|EMBL:KFO38518.1}; GN ORFNames=H920_00077 {ECO:0000313|EMBL:KFO38518.1}; OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Fukomys. OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO38518.1, ECO:0000313|Proteomes:UP000028990}; RN [1] {ECO:0000313|EMBL:KFO38518.1, ECO:0000313|Proteomes:UP000028990} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC TISSUE=Liver {ECO:0000313|EMBL:KFO38518.1}; RA Gladyshev V.N., Fang X.; RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of RT African mole rats."; RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KN113806; KFO38518.1; -; Genomic_DNA. DR RefSeq; XP_010636481.1; XM_010638179.2. DR GeneID; 104871993; -. DR Proteomes; UP000028990; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028990}; KW Reference proteome {ECO:0000313|Proteomes:UP000028990}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 115 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001873991. FT DOMAIN 25 114 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 115 AA; 13293 MW; 157F516746A8FEA5 CRC64; MGVMAPRTLL LLLSGTLVLP ENWAGSHSLR YFNIAVSRPG RGEPRFMSVG YVDDTQFVRF DSDALDPREE PRAAWMEEDQ AYWDRNTQIH KDTAQINRVN LRTLRGYYNQ TEDGE // ID A0A091EMJ7_FUKDA Unreviewed; 363 AA. AC A0A091EMJ7; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 20-DEC-2017, entry version 21. DE SubName: Full=Zinc-alpha-2-glycoprotein {ECO:0000313|EMBL:KFO36836.1}; GN ORFNames=H920_01718 {ECO:0000313|EMBL:KFO36836.1}; OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Fukomys. OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO36836.1, ECO:0000313|Proteomes:UP000028990}; RN [1] {ECO:0000313|EMBL:KFO36836.1, ECO:0000313|Proteomes:UP000028990} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC TISSUE=Liver {ECO:0000313|EMBL:KFO36836.1}; RA Gladyshev V.N., Fang X.; RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of RT African mole rats."; RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KN121214; KFO36836.1; -; Genomic_DNA. DR Proteomes; UP000028990; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000028990}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000028990}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT DOMAIN 258 345 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 216 236 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 363 AA; 41808 MW; 03D4F29073E06461 CRC64; MIWRHLATTF AILPAAVDPN SQTSVLFYME AAVAARSNPN YGHTCLQTVV QSQVTSMENV RRKCKPSPHS QTVSTEGPYS LTFLYIGLSR PSTALPRFQA TAFLNDQAFF RYNSDSRRAE PLGPWRQIKV MEDWEKESQL QKAREEIFLE ALKDIMDYYK DREGSHTFQG MFGCEIRNNR SSRTIWRYAY DGQDFIEFNK EIPAWVPLHP AAQKTKQKWE AEKAYLQRAK AYLEEECPRM LQRYLNYSKA HLDRQDSPSV SITGYSVPRG NKTLKCLAYD FYPQEIGLRW IQASKKQESE SRIHVLPSGN GTYQAWVVVE ISPEDRGPHY CLVEHSGLAQ SLTVPWEEKQ KVGVEGNVKT QSQ // ID A0A091F234_CORBR Unreviewed; 98 AA. AC A0A091F234; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain {ECO:0000313|EMBL:KFO62589.1}; DE Flags: Fragment; GN ORFNames=N302_04333 {ECO:0000313|EMBL:KFO62589.1}; OS Corvus brachyrhynchos (American crow). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae; OC Corvus. OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO62589.1, ECO:0000313|Proteomes:UP000052976}; RN [1] {ECO:0000313|EMBL:KFO62589.1, ECO:0000313|Proteomes:UP000052976} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO62589.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KK719298; KFO62589.1; -; Genomic_DNA. DR Proteomes; UP000052976; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052976}; KW Reference proteome {ECO:0000313|Proteomes:UP000052976}. FT DOMAIN 1 95 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFO62589.1}. FT NON_TER 98 98 {ECO:0000313|EMBL:KFO62589.1}. SQ SEQUENCE 98 AA; 11188 MW; 2EC0B0C98BF2D162 CRC64; RYNQSRGLHT VQRVYGCDLL SDGSSPGFFQ EGYDGRDFIS FEPGSQSFVV ADGAAQVTRR LQNSDGFPVE HWTNYLKHIC PEELREYIGY GREALEHK // ID A0A091FFM3_CORBR Unreviewed; 333 AA. AC A0A091FFM3; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 15. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain {ECO:0000313|EMBL:KFO60355.1}; DE Flags: Fragment; GN ORFNames=N302_15780 {ECO:0000313|EMBL:KFO60355.1}; OS Corvus brachyrhynchos (American crow). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae; OC Corvus. OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO60355.1, ECO:0000313|Proteomes:UP000052976}; RN [1] {ECO:0000313|EMBL:KFO60355.1, ECO:0000313|Proteomes:UP000052976} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO60355.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KK718935; KFO60355.1; -; Genomic_DNA. DR Proteomes; UP000052976; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052976}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000052976}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 279 303 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 183 261 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFO60355.1}. FT NON_TER 333 333 {ECO:0000313|EMBL:KFO60355.1}. SQ SEQUENCE 333 AA; 37385 MW; AF391103A91C584E CRC64; VLHSLRYLSV AVSEPGPGIP QFMSMGFLDG IPFQRYDSER GRDEPLTPWM EEGPKPGYWD SETETSKRSQ QMDAVNLETV RGRYNQSGGL HTLQRDCGCD LLSDGRVRGS YWLGYDGQDF LSFEPRSQSF VAANSAAQVT TRSWNSDGVT VEHWTNYLEH ICTEGLQKYV EYGREALERK EPPDVHVSGK EEFGTLILSC HVYGFYPRPI AVSWMKGDEI RDQETEWGGI VPNSDGTFHT WARIEVQPEE REQYRCRVEH SGMPEPGIFA LEPESGRNLT LVVAVFVIAA IVILILLVGF IVWKLQSGRR QNHGYSPPAG KDMGTNGSSA GTE // ID A0A091G3T6_9AVES Unreviewed; 184 AA. AC A0A091G3T6; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 14. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain {ECO:0000313|EMBL:KFO77225.1}; DE Flags: Fragment; GN ORFNames=N303_06519 {ECO:0000313|EMBL:KFO77225.1}; OS Cuculus canorus (common cuckoo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus. OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO77225.1, ECO:0000313|Proteomes:UP000053760}; RN [1] {ECO:0000313|EMBL:KFO77225.1, ECO:0000313|Proteomes:UP000053760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO77225.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KL447803; KFO77225.1; -; Genomic_DNA. DR Proteomes; UP000053760; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053760}; KW Reference proteome {ECO:0000313|Proteomes:UP000053760}. FT DOMAIN 95 184 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFO77225.1}. FT NON_TER 184 184 {ECO:0000313|EMBL:KFO77225.1}. SQ SEQUENCE 184 AA; 21301 MW; A1503EEFF7D16035 CRC64; GFHTLQRRYG CELLEDGSIS GFYRGAYDGK DFIALDMDTM TFVVWDTVAE VTKRQWEEEG RQAKLWKDFL KNTCIKWLRK YLSYGQAVLE RKELPVVHVS GKEAEGILTL RCHVYGFYPR PIVVSWLKDG EVRDQDTVWS SIAPNSDGTY YVSASIDVHP EEKHKYRCRV EHASLAQPGL FAWD // ID A0A091GAA1_9AVES Unreviewed; 188 AA. AC A0A091GAA1; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 14. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain {ECO:0000313|EMBL:KFO78858.1}; DE Flags: Fragment; GN ORFNames=N303_04700 {ECO:0000313|EMBL:KFO78858.1}; OS Cuculus canorus (common cuckoo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus. OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO78858.1, ECO:0000313|Proteomes:UP000053760}; RN [1] {ECO:0000313|EMBL:KFO78858.1, ECO:0000313|Proteomes:UP000053760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO78858.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KL447953; KFO78858.1; -; Genomic_DNA. DR Proteomes; UP000053760; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053760}; KW Reference proteome {ECO:0000313|Proteomes:UP000053760}. FT DOMAIN 76 174 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFO78858.1}. FT NON_TER 188 188 {ECO:0000313|EMBL:KFO78858.1}. SQ SEQUENCE 188 AA; 21900 MW; FBCD4EA106B317A0 CRC64; GVHTIQVMHG CDLLEDNSTK GYYQVAYDGK DFISLDMEKK KFIAADVGAI DTKIKWEKDD MVADRRKNYV ENICIPWLKN YVEYGKEVLE RKGESETANG RRRFGRFLTL RCRVYGFYPR LISFNCEKDN EVRDQDTMWS SIAPNSDGTF YTAAAIDIHP EEREKYRCRV DHSSLSEPGL YAWDEPPE // ID A0A091J688_EGRGA Unreviewed; 186 AA. AC A0A091J688; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 22-NOV-2017, entry version 16. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain {ECO:0000313|EMBL:KFP16464.1}; DE Flags: Fragment; GN ORFNames=Z169_14343 {ECO:0000313|EMBL:KFP16464.1}; OS Egretta garzetta (Little egret). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Ardeidae; Egretta. OX NCBI_TaxID=188379 {ECO:0000313|EMBL:KFP16464.1, ECO:0000313|Proteomes:UP000053119}; RN [1] {ECO:0000313|EMBL:KFP16464.1, ECO:0000313|Proteomes:UP000053119} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_Z169 {ECO:0000313|EMBL:KFP16464.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KK501578; KFP16464.1; -; Genomic_DNA. DR Proteomes; UP000053119; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053119}; KW Reference proteome {ECO:0000313|Proteomes:UP000053119}. FT DOMAIN 95 174 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFP16464.1}. FT NON_TER 186 186 {ECO:0000313|EMBL:KFP16464.1}. SQ SEQUENCE 186 AA; 21447 MW; 420084C667488AE1 CRC64; GAHTWQRMVG CDLLEDNSTR GYSQYAYDGR DYIAFDMDTM TFTAADAAAQ ITKRKWEVDG TEAERQKHYL KDTCIEWLRK YVSYGRAVLE RKERPVVRVS GKEAHGTLTL SCRAYGFYPR PIRVSWLKDG EVRDQETERG GIVPNSDGTY YTWASIEARP EEKDKYRCRV EHASLGEPGL FVWGEP // ID A0A091QR73_9GRUI Unreviewed; 174 AA. AC A0A091QR73; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 14. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain {ECO:0000313|EMBL:KFQ29111.1}; DE Flags: Fragment; GN ORFNames=N332_13702 {ECO:0000313|EMBL:KFQ29111.1}; OS Mesitornis unicolor (brown roatelo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Gruiformes; Mesitornithidae; OC Mesitornis. OX NCBI_TaxID=54374 {ECO:0000313|EMBL:KFQ29111.1, ECO:0000313|Proteomes:UP000053369}; RN [1] {ECO:0000313|EMBL:KFQ29111.1, ECO:0000313|Proteomes:UP000053369} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N332 {ECO:0000313|EMBL:KFQ29111.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KK801513; KFQ29111.1; -; Genomic_DNA. DR Proteomes; UP000053369; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053369}; KW Reference proteome {ECO:0000313|Proteomes:UP000053369}. FT DOMAIN 3 88 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFQ29111.1}. FT NON_TER 174 174 {ECO:0000313|EMBL:KFQ29111.1}. SQ SEQUENCE 174 AA; 19604 MW; 1C89BF0E167A60F6 CRC64; GAQMWQYMVG CDLLEDGSTR GFYQHAYDGR DFIALDKDTM TFTAVDTVAQ ITKKEWEEGP EAESQKYCLE NSCIERLRKY LSYGRAVLER KGEGKTGTLG TGCCGTVCRP SLPPPPQSAP RDQQTEWGSI APNSDGTFYT WASIEARPEE KDKYRCRVDH VSLREPSLFA WGEP // ID A0A091USG0_NIPNI Unreviewed; 100 AA. AC A0A091USG0; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain {ECO:0000313|EMBL:KFQ93904.1}; DE Flags: Fragment; GN ORFNames=Y956_12245 {ECO:0000313|EMBL:KFQ93904.1}; OS Nipponia nippon (Crested ibis) (Ibis nippon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae; OC Nipponia. OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ93904.1, ECO:0000313|Proteomes:UP000053283}; RN [1] {ECO:0000313|EMBL:KFQ93904.1, ECO:0000313|Proteomes:UP000053283} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ93904.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KL410070; KFQ93904.1; -; Genomic_DNA. DR Proteomes; UP000053283; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053283}; KW Reference proteome {ECO:0000313|Proteomes:UP000053283}. FT DOMAIN 2 97 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFQ93904.1}. FT NON_TER 100 100 {ECO:0000313|EMBL:KFQ93904.1}. SQ SEQUENCE 100 AA; 11723 MW; 12D4DCC345F2054F CRC64; RARYNQSRGA HTLQRVYGCD LLEDGSTRGY WQMGYDGRDF IAFDMDTMTF TAADAVPQII KQECKEDGTE AERKKHYLQN TCIEWLRKYV SYGRAVLERK // ID A0A091WTK6_OPIHO Unreviewed; 181 AA. AC A0A091WTK6; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 14. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain {ECO:0000313|EMBL:KFR04791.1}; DE Flags: Fragment; GN ORFNames=N306_00251 {ECO:0000313|EMBL:KFR04791.1}; OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae; OC Opisthocomus. OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR04791.1, ECO:0000313|Proteomes:UP000053605}; RN [1] {ECO:0000313|EMBL:KFR04791.1, ECO:0000313|Proteomes:UP000053605} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR04791.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KK734151; KFR04791.1; -; Genomic_DNA. DR PhylomeDB; A0A091WTK6; -. DR Proteomes; UP000053605; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053605}; KW Reference proteome {ECO:0000313|Proteomes:UP000053605}. FT DOMAIN 88 168 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFR04791.1}. FT NON_TER 181 181 {ECO:0000313|EMBL:KFR04791.1}. SQ SEQUENCE 181 AA; 20977 MW; 1547269D13B5E7B6 CRC64; QRMYGCDLLE DGSTRGFYQE AYDGRDFIAL DEDMTGFIAA DAVAQITKRK WEDEDEAKRW KHYLQNDCIE WLKKYMSYGQ KVLERKEPPT VRVSGKEADG ILTLSCRAYG FYPRAISVSW LKDGEVRDQE TEWGSVAPNS DGTYYTWASI DARPEEKDKY RCRVEHASLL EPGLHAWGEP R // ID A0A093BJY6_CHAPE Unreviewed; 183 AA. AC A0A093BJY6; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain {ECO:0000313|EMBL:KFU86657.1}; DE Flags: Fragment; GN ORFNames=M959_14984 {ECO:0000313|EMBL:KFU86657.1}; OS Chaetura pelagica (Chimney swift). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Apodiformes; Apodidae; Chaetura. OX NCBI_TaxID=8897 {ECO:0000313|EMBL:KFU86657.1, ECO:0000313|Proteomes:UP000031515}; RN [1] {ECO:0000313|EMBL:KFU86657.1, ECO:0000313|Proteomes:UP000031515} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=M959 {ECO:0000313|EMBL:KFU86657.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KN126094; KFU86657.1; -; Genomic_DNA. DR Proteomes; UP000031515; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000031515}; KW Reference proteome {ECO:0000313|Proteomes:UP000031515}. FT DOMAIN 94 174 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFU86657.1}. FT NON_TER 183 183 {ECO:0000313|EMBL:KFU86657.1}. SQ SEQUENCE 183 AA; 21045 MW; 53EB79AF19058B0F CRC64; GAHTVQKMYG CDLLEDGTIR GYRQYAYDGR DFISFDLDTM TFIAADAAAQ ITKRKWEEDE AEAERVKNYL ETICIEWLRR YVSNGRAVLE RKEPPTVRVS GQEAHGVLTL SCRAYGFYPR PISISWLREG EVRDQDTEWG SVAPNSDGTF YSWASIEARP EERDKYQCRV EHASLAQPGL YAW // ID A0A093BYH1_TAUER Unreviewed; 182 AA. AC A0A093BYH1; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 14. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain {ECO:0000313|EMBL:KFV08760.1}; DE Flags: Fragment; GN ORFNames=N340_08506 {ECO:0000313|EMBL:KFV08760.1}; OS Tauraco erythrolophus (Red-crested turaco). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Musophagiformes; Musophagidae; OC Tauraco. OX NCBI_TaxID=121530 {ECO:0000313|EMBL:KFV08760.1, ECO:0000313|Proteomes:UP000053661}; RN [1] {ECO:0000313|EMBL:KFV08760.1, ECO:0000313|Proteomes:UP000053661} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N340 {ECO:0000313|EMBL:KFV08760.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KL455306; KFV08760.1; -; Genomic_DNA. DR Proteomes; UP000053661; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053661}; KW Reference proteome {ECO:0000313|Proteomes:UP000053661}. FT DOMAIN 90 170 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFV08760.1}. FT NON_TER 182 182 {ECO:0000313|EMBL:KFV08760.1}. SQ SEQUENCE 182 AA; 20791 MW; BDDC2D879F1AF9DC CRC64; GAQTLQEMYG CDLLEDGGTK GYYRIAYDRK DVITTMTFTA ADKAAQVTKR NWEKDGAEAE RMKHYLENTC IEWLRKFVSY GRAVLERKEP PTVRVSGKEA DGILTLSCRA YGFYPRRIAV SWLKDGEVRD QETERGSVAP NSDGTFYTWA SIEARPEERS KYRCRVEHAS LPEPGLYAWG EP // ID A0A093I7E1_STRCA Unreviewed; 186 AA. AC A0A093I7E1; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 14. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain {ECO:0000313|EMBL:KFV87790.1}; DE Flags: Fragment; GN ORFNames=N308_13588 {ECO:0000313|EMBL:KFV87790.1}; OS Struthio camelus australis. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae; OC Struthio. OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV87790.1, ECO:0000313|Proteomes:UP000053584}; RN [1] {ECO:0000313|EMBL:KFV87790.1, ECO:0000313|Proteomes:UP000053584} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV87790.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KL206978; KFV87790.1; -; Genomic_DNA. DR Proteomes; UP000053584; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053584}; KW Reference proteome {ECO:0000313|Proteomes:UP000053584}. FT DOMAIN 95 182 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFV87790.1}. FT NON_TER 186 186 {ECO:0000313|EMBL:KFV87790.1}. SQ SEQUENCE 186 AA; 21148 MW; 5D8C61A0B4F97DC3 CRC64; GYHTVQRMFG CDLLEDGRIE GFQQYAYDGK DFISFDKKTL TFTAADLGAQ ITKKKWEGDP SIADRWKHYL EETCIEWLQK YVAHGKATLE RRERPAVRVS GKESHGVLTL SCRAHGFHPR PSTSSWLKKG TVRDQETKRG SITPNSDGTY HTWASIEALP AEKDEYQCRV DHASLPEPGV FSWGEP // ID A0A093PPV2_9PASS Unreviewed; 91 AA. AC A0A093PPV2; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain {ECO:0000313|EMBL:KFW76270.1}; DE Flags: Fragment; GN ORFNames=N305_09624 {ECO:0000313|EMBL:KFW76270.1}; OS Manacus vitellinus (golden-collared manakin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus. OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW76270.1, ECO:0000313|Proteomes:UP000053258}; RN [1] {ECO:0000313|EMBL:KFW76270.1, ECO:0000313|Proteomes:UP000053258} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW76270.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KL669403; KFW76270.1; -; Genomic_DNA. DR Proteomes; UP000053258; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053258}; KW Reference proteome {ECO:0000313|Proteomes:UP000053258}. FT DOMAIN 2 88 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFW76270.1}. FT NON_TER 91 91 {ECO:0000313|EMBL:KFW76270.1}. SQ SEQUENCE 91 AA; 10243 MW; 3722D25F8494C2E8 CRC64; LHTLQRDCGC ELLSNGNVRG SYREGYDGRD FLSFELGSGS FVAADGAAQI IKRHWDSDGI TVDRLTNFLE HTCLEVLQKH VQYGQEVLEK K // ID A0A093QRG7_9PASS Unreviewed; 100 AA. AC A0A093QRG7; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain {ECO:0000313|EMBL:KFW86547.1}; DE Flags: Fragment; GN ORFNames=N305_01704 {ECO:0000313|EMBL:KFW86547.1}; OS Manacus vitellinus (golden-collared manakin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus. OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW86547.1, ECO:0000313|Proteomes:UP000053258}; RN [1] {ECO:0000313|EMBL:KFW86547.1, ECO:0000313|Proteomes:UP000053258} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW86547.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KL672588; KFW86547.1; -; Genomic_DNA. DR Proteomes; UP000053258; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053258}; KW Reference proteome {ECO:0000313|Proteomes:UP000053258}. FT DOMAIN 2 97 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFW86547.1}. FT NON_TER 100 100 {ECO:0000313|EMBL:KFW86547.1}. SQ SEQUENCE 100 AA; 11566 MW; F83B0C97DAA2C021 CRC64; RDRYNWSGGL HTWQRVAGCD LLSDGSVRGF YRYGYDGRDF ISFELGSGSF VAADGAAQIT KRKWEHDGIV AERQTHYLKN ICPEWLRKYV GYGREALERK // ID A0A093QS05_9PASS Unreviewed; 82 AA. AC A0A093QS05; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=H-2 class I histocompatibility antigen, Q7 alpha chain {ECO:0000313|EMBL:KFW86742.1}; DE Flags: Fragment; GN ORFNames=N305_00662 {ECO:0000313|EMBL:KFW86742.1}; OS Manacus vitellinus (golden-collared manakin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus. OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW86742.1, ECO:0000313|Proteomes:UP000053258}; RN [1] {ECO:0000313|EMBL:KFW86742.1, ECO:0000313|Proteomes:UP000053258} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW86742.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KL672674; KFW86742.1; -; Genomic_DNA. DR Proteomes; UP000053258; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053258}; KW Reference proteome {ECO:0000313|Proteomes:UP000053258}. FT DOMAIN 1 78 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFW86742.1}. FT NON_TER 82 82 {ECO:0000313|EMBL:KFW86742.1}. SQ SEQUENCE 82 AA; 9468 MW; DB276CDF3ABD8466 CRC64; CDLLSDRSIR GSCREAYNGR DFISFELGSR SFVAVDGATQ ITERKWEHSG IMVERKTHYL ENICPEALQK FVGYGWEVLE HK // ID A0A096LQF0_POEFO Unreviewed; 201 AA. AC A0A096LQF0; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 20. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000021391}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000021391, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000021391, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000021391}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000021391} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010096; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AYCK01010097; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AYCK01010098; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AYCK01010099; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000023207; ENSPFOP00000021391; ENSPFOG00000022893. DR GeneTree; ENSGT00740000114936; -. DR OMA; YLEGICI; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}. FT DOMAIN 89 163 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 201 AA; 23518 MW; 3AAFABFE59B6DD82 CRC64; MYGCEFDDEY KEVEGWESFG YDGEDFIAFD LKSEEWSAPV HQAFITKNRW DNDKMKVTQT KYYITQTCPD WLKKYLEYGR NSLVRTDVPS VSFLQKSPSS PVSCFATGFY PSRAEMFWRK DEEEIHAGVN KGEILSNNDR TFQISVDLNL SSVPPEDWTK YECVFHLSGF KCDVVNRLEK SKIRINVEGE NKMRSGKRFT K // ID A0A096LQZ6_POEFO Unreviewed; 245 AA. AC A0A096LQZ6; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 15. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000021587}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000021587, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000021587, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000021587}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000021587} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010112; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000024818; ENSPFOP00000021587; ENSPFOG00000021903. DR GeneTree; ENSGT00740000114936; -. DR OMA; FCHAISA; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 245 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001926490. FT DOMAIN 21 193 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 245 AA; 27980 MW; C632F1CE189D68BC CRC64; MKWLVILLMF SQGSSAETHV LKVYFTGSSG LTSFLPFEAV GRLDDIDTSH CNNEAIDAKI GWVKKLLSDN PKIFELLKRF CFIDNPAFFK YIIAELMKNF NQTEGIHTFQ MVGGCQLNIE TKELKGFLKY GYDGEDFVEF DLKGLKWIAL KKEAVFLKQL WDMDTRDLEF HHYALTDLCY EILNTTLVYG QSSLFKTGTV LHRYLLTDLC YGLFNTSLVS GQSSLFKTDT VLQLTECTSI QSAET // ID A0A096LT73_POEFO Unreviewed; 353 AA. AC A0A096LT73; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 21. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000022364}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000022364, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000022364, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000022364}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000022364} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010109; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000025273; ENSPFOP00000022364; ENSPFOG00000023830. DR GeneTree; ENSGT00740000114936; -. DR OMA; HIDLNIS; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 353 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001926562. FT TRANSMEM 308 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 274 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 353 AA; 40635 MW; 2F6F9CF6CA605204 CRC64; MIRLLCLLLL CNIFLAEIHV LNIYYTASSK AKNNTEFELV LDIDGNVLGS CDHEILKTNY DWGKKMLNDY REVHEFYTVQ CFQILPRFFD YKISSVRKDT SQPEGVHIFQ RIDRCNFDED TGEVDSSMRF GYDGEDFLEL DLDKLSWVAL SPQAAQTKRT WETEIVELHF YKELLTYKCP LWLKISLDYG KSVLRRTDLP SVSLLQKTPS SPIRCHATGF YPYRAHLFWR KDGQETHEDV EHGDILPNDD GSFQMMTDLN VSSINIEDWR RFDCVFHLSS AADKVIIKLD KSVIKTNYGR AHQKTAPIVA TVLVFGAVAI AVGIFAVCKI KKKRTDHRTF GILTNSSSQE ASF // ID A0A096LV57_POEFO Unreviewed; 340 AA. AC A0A096LV57; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000023048}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000023048, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000023048, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000023048}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000023048} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010109; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000028057; ENSPFOP00000023048; ENSPFOG00000023830. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 15 {ECO:0000256|SAM:SignalP}. FT CHAIN 16 340 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013085113. FT DOMAIN 202 276 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 39439 MW; CADB0E828B9BDC92 CRC64; MKMLFLLLLC ASSSPVPKEI HVLNIYYTAS SKAKNNTEFE LVLDIDGNVL GSCDHEILKT NYDWGKKMLN DYREVHEFYT VQCFQILPRF FDYKISSVRK DTSQPEGVHI FQRIDRCNFD EDTGEVDSSM RFGYDGEDFL ELDLDKLSWV ALSPQAAQTK RTWETEIVEL HFYKELLTYK CPLWLKISLD YGKSVLRRTD LPSVSLLQKT PSSPIRCHAT GFYPYRAHLF WRKDGQETHE DVEHGDILPN DDGSFQMMTD LNVSSINIED WRRFDCVFHL SSAADKVIIK LDKSVIKTNY DAGTSIILIK IYTAEEAVII IIDFYFISSN VRNQSEMTFC // ID A0A096LWA6_POEFO Unreviewed; 342 AA. AC A0A096LWA6; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000023447}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000023447, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000023447, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000023447}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000023447} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010112; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000024221; ENSPFOP00000023447; ENSPFOG00000006404. DR GeneTree; ENSGT00740000114936; -. DR OMA; HIFQRIH; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 15 {ECO:0000256|SAM:SignalP}. FT CHAIN 16 342 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012655569. FT TRANSMEM 306 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 342 AA; 39133 MW; B51F0C196C283441 CRC64; MNCFGLLLLF HVASSVKHSL RYFLTATHGV HDFPEFFGAA TVDEVQVGYC DSNIKTAKPK QDWMMKLIER NPEHLEWYSQ KCLGSQHVFR ANIDILKQRL NLTKGPHILQ RMNGCEWDDE TGEVIGFNQY GYNGEDFLAL DLKTLTWTAP KSQAVLTKLI WDGEKARLEH NKNYYIYKCP DWLKNYIRHG KSFLQRTENP SISLLQRTPS SVVSCHATGF FPGRAEMFWT KDGEEIHEDV EKGEILFNND GTFQMSVEFN VSSVPPDGWR RYDCVFQFSG VGDNIKTTLD KSVIYTNWAY PPEFPVAPVA GIAGGFLLLL VIAVIVLWLK KRTGFQRVDG ED // ID A0A096LWD4_POEFO Unreviewed; 354 AA. AC A0A096LWD4; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 22. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000023475}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000023475, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000023475, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000023475}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000023475} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010109; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000024656; ENSPFOP00000023475; ENSPFOG00000023255. DR GeneTree; ENSGT00740000114936; -. DR OMA; DETRTVD; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 273 295 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 166 259 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 354 AA; 39636 MW; 97AC39AE049B1329 CRC64; MLMGVGSSGL PNLPTFCANI EIDEIRVAYC DSNRKTLNSA FDSSYSGFCF HLPDNFAHKL NYLKDFQYEA VGILQMITGC EWDDATGDVG IFLKFAYNGE DLFELDVKNL TWIAKNHQAV MVKDKWTNDE DTPLKNSVPL LKNVCPEDLK KYVSHGDHSQ QKKGLPSVSL LQRTPSSPIR CHVTGFYPNS GQLYWRKNGE EIHEYVEHGE ILPNPDGTFQ MSVDFNVSSI PLEDWGKYDC VFQQPGLGNI TTKLDKAVIR TNRVSPTDFP SHVISGVVGG LVLLLALCIS GFIFWKKKNN GFQPANRSDK IEENSELQSF KDETRTVDGD QTSSNEQNHE KANGAEQIPE TGIN // ID A0A096LYG1_POEFO Unreviewed; 235 AA. AC A0A096LYG1; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 19. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000024202}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000024202, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000024202, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000024202}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000024202} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010111; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AYCK01010112; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000022756; ENSPFOP00000024202; ENSPFOG00000022409. DR GeneTree; ENSGT00740000114936; -. DR OMA; LANRIMF; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}. FT DOMAIN 115 201 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 235 AA; 27251 MW; E86C8E5453F6FFD6 CRC64; MSCCFDVISL HPNIFYVFIS GVHIFQRTNG CFWDDETEEF DGFNEYGYDG DDLIRFDLKT LTWISPRHQT VINKHNWDRD GSSLFWKHAL TEDCIHFLKL YLNYGKSSLQ TAVHPSVSLL QKTPSSVVTC HATGFYPERA TMFWRKDGQE LHEGVEKGEI LPNNDGTFQM SVDLNISSVT AEDWRRHDCS FLFASLKDSI TTRLDRTMIR TNQGMIQVEK KGSFPLVFVF HWNNS // ID A0A096M6D1_POEFO Unreviewed; 358 AA. AC A0A096M6D1; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 21. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000026972}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000026972, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000026972, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000026972}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000026972} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010094; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AYCK01010095; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000026198; ENSPFOP00000026972; ENSPFOG00000001994. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 30 {ECO:0000256|SAM:SignalP}. FT CHAIN 31 358 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001927657. FT TRANSMEM 299 319 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 190 264 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 358 AA; 40465 MW; 419A93F362259227 CRC64; MWTTELVRSS MVKMMKFVFL ILLGIHSTAA VTHSLKYFYT ASSGIKNFPE FVTVGMVDEV PVSYYDSVIR KEIPKQDWLA KNEGPEYWES NTQISIGSEQ SFKADIGIIK QRFNQTGGVH VVQVMYGCEW DDETQKVTGY RQFGYDGEDF LTLNTETNTW IAPQPQAICP EWLKKYVGYG RSSLMRTELP SVSLLQRFSS SPVSCHATGF YPDTAEMSWR KDGEEIHDGV EKGEILSNHD GTFQMSVNIY LESVPPEDWT KYECVFLLSG VERDVIRLEK TRIRTNELKS VSTVNRNTTI IPVVVVFLCL IGLIGFFLYK KNKGSQDTKT SPSCPEASSL TSKSSDDSQG RTSDKSLL // ID A0A096M705_POEFO Unreviewed; 265 AA. AC A0A096M705; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 19. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000027196}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000027196, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000027196, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000027196}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000027196} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01029482; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000029212; ENSPFOP00000027196; ENSPFOG00000005918. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 265 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001920094. FT TRANSMEM 214 239 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 113 199 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 265 AA; 29975 MW; 3CB8CBC57155FB48 CRC64; MRNKPNLFSS SFYLCLSGVH VVQVMYGCEW DDETQKVTGY RQFGYDGEDF LTLNTETNTW IAPQPQAVLT TNKWNNNRAL LESDKNYLNQ ICPEWLKKYV GYGRSSLMRT ERPSVSVLQK SSSSPISCFA TGFYPNRAEM FWRKDGEEIH DGVEKGEIVP NNDGTFQMSV HIDLSSVPTE DRNKYECVFQ LSGDKEDVTN RLEKTRILTN ESNISIVIIL VVAAVAVLGL IAVIGFIVYK KMNAKRPPSP VNGPPPEETQ FLPQT // ID A0A096M7B1_POEFO Unreviewed; 397 AA. AC A0A096M7B1; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 19. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000027302}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000027302, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000027302, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000027302}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000027302} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01012830; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AYCK01012831; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000022836; ENSPFOP00000027302; ENSPFOG00000004058. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 270 292 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 165 254 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 397 AA; 45348 MW; DDD71873CDAC065A CRC64; MGLLDNNMID YYDSEHQVKV PKQDWMEKHL EPEYWEKGTQ SRKSKQQWFK VNIDILMKRM RQNDNDTHIL QWMHGCEGET QPDGSLKFVR GMDMYNYDGS DFLSFDDNHQ VWVAPIHAAE ETKRKWDEVQ VLKEYTKGYL EKECMEWMSK FRGFGKEKIE KASPPEVYLF TRKVNIEQNI ILTCLATGFY PGEIILNIKR NGRVLTKEDG LVTSGYRPNH DHTFQRRDHV EILKSDVSAY ICEVEHLASK RHVNQTWENP FVEDKGNTNV IIAASASIVI VVVAVAVTLV CLKLRTSRLD CDEENSPHSS LSSVASSGSD KPVRDKKKPD ENNPLLDTDK PVSDLKKPDE KKPLLDNDGD SMISSESGRA STQSLNSEDS SGSKKTNPSN DSGAERK // ID A0A096MC61_POEFO Unreviewed; 341 AA. AC A0A096MC61; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 23. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000029002}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000029002, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000029002, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000029002}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000029002} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010109; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000027834; ENSPFOP00000029002; ENSPFOG00000022915. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT DOMAIN 182 268 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 289 317 IGc1. {ECO:0000259|Pfam:PF07654}. SQ SEQUENCE 341 AA; 38624 MW; 5D62CFE85BAD7ECD CRC64; MSTQEIKKIN SNSSSIGKLV QEFMHFTQKK LLCSSVSLSD PLLFSVFLCH QLVPVSSALI KILYIPNETK TPQRARPANS SGTKTLQVKL DMEMFLLLLL LHCVSSVKHT LMLMGVGSSG LPNLPTFCAN IEIDEIRVAY CDSNRKTLNS TFDSSYSGFC FHLPDIFANK LNYLKDFQYE AVDILQVIAG CEWDDVTGEA GILLKHAYNG EDLFEWDVKN LTWIAKSHQA VMVKDKWKND EDARLEMNLS LLMKFCPERL KKDVAHGDNS QQKRGLPSVS LLQKTPSSPI RCHVTGFYPN RGQLYWRENG EEIHEYVEHG LGEVRLCLSA AWVRKHHNQT G // ID A0A096MCV4_POEFO Unreviewed; 250 AA. AC A0A096MCV4; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 17. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000029245}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000029245, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000029245, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000029245}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000029245} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010109; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000032040; ENSPFOP00000029245; ENSPFOG00000024841. DR GeneTree; ENSGT00740000114936; -. DR OMA; FLMRTGN; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 15 {ECO:0000256|SAM:SignalP}. FT CHAIN 16 250 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012633203. FT DOMAIN 86 191 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 250 AA; 29633 MW; 94E4AE388BB257C7 CRC64; RWFLLTLIFC LLSSAEKHFL KFYQIGSSGL PHVSQVEIVA EVDGSLVGYC NRTDIRITHD WAKKFLDDDV ELLTLFKMKC FHQLPNIFQT KISDLKQRLK QPEGVYIVQW IDFCSWDTET GELTGSIMNY NGEDFLALDI ERDSWIPLKQ QAIPIKLAWD NDKDRIHHNR IFISQMCPDW LKRSLDYGRN FLMRTGNMTR SSFNLYHRIT LSLCSFTLGS FWVRWIFAQP KHEQTFLTYF LHSEYENIKL // ID A0A096MI76_POEFO Unreviewed; 242 AA. AC A0A096MI76; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 19. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000031117}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000031117, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000031117, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000031117}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000031117} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01029482; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000025830; ENSPFOP00000031117; ENSPFOG00000005918. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 242 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001921397. FT TRANSMEM 191 216 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 90 176 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 242 AA; 27244 MW; 0490B31E69608E54 CRC64; MRNKPNLFSS SFYLCLSGVH VVQVMYGCEW DDETQKVTGY RQFGYDGEDF LTLNTETNTW IAPQPQAICP EWLKKYVGYG RSSLMRTERP SVSVLQKSSS SPISCFATGF YPNRAEMFWR KDGEEIHDGV EKGEIVPNND GTFQMSVHID LSSVPTEDRN KYECVFQLSG DKEDVTNRLE KTRILTNESN ISIVIILVVA AVAVLGLIAV IGFIVYKKMN AKRPPSPVNG PPPEETQFLP QT // ID A0A096MIE6_POEFO Unreviewed; 421 AA. AC A0A096MIE6; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 22. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000031187}; OS Poecilia formosa (Amazon molly) (Limia formosa). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Poecilia. OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000031187, ECO:0000313|Proteomes:UP000028760}; RN [1] {ECO:0000313|Ensembl:ENSPFOP00000031187, ECO:0000313|Proteomes:UP000028760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000031187}; RA Schartl M., Warren W.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPFOP00000031187} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AYCK01010109; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPFOT00000025440; ENSPFOP00000031187; ENSPFOG00000022915. DR GeneTree; ENSGT00740000114936; -. DR OMA; ADIVNIM; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028760}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028760}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 384 406 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 277 370 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 421 AA; 47402 MW; EAE50AFAD26BA195 CRC64; MSTQEIKKIN SNSSSIGKLV QEFMHFTQKK LLCSSVSLSD PLLFSVFLCH QLVPVSSALI KILYIPNETK TPQRARPANS SGTKTLQVKL DMEMFLLLLL LHCVSSVKHT LMLMGVGSSG LPNLPTFCAN IEIDEIRVAY CDSNRKTLNS TFDSSYSGFC FHLPDIFANK LNYLKDFQYE AVDILQVIAG CEWDDVTGEA GILLKHAYNG EDLFEWDVKN LTWIAKSHQA VMVKDKWKND EDARLEMNLS LLMKFCPERL KKDVAHGDNS QQKRGLPSVS LLQKTPSSPI RCHVTGFYPN RGQLYWRENG EEIHEYVEHG EILPNPDGTF QMSVDFNVSS IPLEDWGKYD CVFQQPGLGN ITTKLDKAVI RTNRVSPTDF PSHVISGVVV GLVLLVALFI SGFIFWKKKN NGFQPANNLT K // ID A0A096N132_PAPAN Unreviewed; 385 AA. AC A0A096N132; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 28. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSPANP00000005974}; GN Name=MR1 {ECO:0000313|Ensembl:ENSPANP00000005974}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000005974, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000005974, ECO:0000313|Proteomes:UP000028761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., RA Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., RA Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B., RA Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B., RA Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C., RA Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D., RA Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F., RA Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G., RA Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J., RA Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J., RA Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K., RA Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L., RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L., RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M., RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N., RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O., RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., RA Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., RA Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S., RA Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T., RA Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U., RA Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W., RA Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W., RA Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N., RA Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.; RT "Whole Genome Assembly of Papio anubis."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPANP00000005974} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHZZ02017610; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_009190456.1; XM_009192192.2. DR Ensembl; ENSPANT00000004206; ENSPANP00000005974; ENSPANG00000009258. DR GeneID; 101021550; -. DR GeneTree; ENSGT00740000114936; -. DR OMA; GYVDSHP; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028761; Chromosome 1. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 44 61 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 344 367 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 247 343 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 385 AA; 44675 MW; 459B05E325FB965D CRC64; MTLHIFRCSY WEKALCVTQL LNHPRGSQKG PVSFRFKEPR KRRTIGELMV FLLPLVVVVM VKHSDSRTHS LRYFRLGVSD PGHGVPEFIS VGYVDSQPIT TYDSVTRQKE PRAPWMAENL APDHWERYTQ LLRGWQQTFK VELKRLQRHY NHSGSHTYQR MIGCELLEDG STTGFLQYAY DGQDFLIFNK DSLSWLAVDN VAHTVKRAWE ANQHELRYQK NWLEKECIAW LKRFLEYGND TLQRTEPPLV RVNRKETFPG VTTLFCKAYG FYPPEIYMTW MKNGEEIVQE MDYGDILPSG DGTYQTWASV ELDPKSSNLY SCHVEHCGVH MVLQVPQESE TIPLVMKAVS GSIILVIVLA GVGVLVWRRR PREQNGAMYL PTPDR // ID A0A096N4H5_PAPAN Unreviewed; 388 AA. AC A0A096N4H5; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 23-MAY-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000007293}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000007293, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000007293} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSPANT00000010178; ENSPANP00000007293; ENSPANG00000023606. DR GeneTree; ENSGT00760000118960; -. DR OMA; VPGYYNQ; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000028761; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 388 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014150777. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 388 AA; 43631 MW; 8F3C4C03688F0E9A CRC64; MAPRTLLLLL SGALALTETW AGSHSMKYFY TAVSRPGRWE PHFISVGYVD DTQFVRFDSD AESPRKEPRA PWAEQEGPEY WEEQTRRAKA NAQADRMCLR TVPGYYNQSE AGSHTFQSMY GCDLGPDWRL LRGYYQSAYD GRDYIALNED LLSWTSADVA AQNTQREWEA DRYAEQWRAY LEGECVESLR RYLENGKETL QRADPPKTHV THHPISNHEA TLRCWALGFY PAEITLTWQR DGEDQTQDTE LVETRPAGDG TFQKWGAVVV PSGEEQRYTC HVQHEGLPEP LTLRWEPSSQ STIPIVGIVA GLAVVAVVVT GAVVAAVMWR RKSSGAKGGS YSQAACKWWG WECGGAHPSH NSSCPMSPAG SDHVLFLFYP SQRQCPGL // ID A0A096N809_PAPAN Unreviewed; 370 AA. AC A0A096N809; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 20-JUN-2018, entry version 26. DE SubName: Full=HLA class I histocompatibility antigen, B-27 alpha chain precursor {ECO:0000313|Ensembl:ENSPANP00000008727}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000008727, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000008727} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSPANT00000020466; ENSPANP00000008727; ENSPANG00000030071. DR GeneTree; ENSGT00760000118960; -. DR OMA; TESWIAP; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000028761; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 370 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014142414. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 370 AA; 41392 MW; D3DE6934805A7DC0 CRC64; MRVMAPRTLL LLLSGVLALT ETWAGSHSLR YFYTTVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRME PRAPWMEQEG PEYWEEETRI AKARAQTDRV DLGTLLRYYN QSEGGSHTIQ MMYGCDLGPD GHLLRGYRQD AYDGKDYIAL NEDLRSWTAA DVEAQNTQRK WEAAGDAEQW RAYLEGECPE WLRRYLQNRK ETLQPADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DIEFVETRPG GDGTFQKWGA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQSTIPIVG IVVGLAVLAV VVTGAVVAAV MWRRKSSGHF LPTGGKGGSY SQAASNDSAQ GSDVSLMAKA // ID A0A096N8U6_PAPAN Unreviewed; 298 AA. AC A0A096N8U6; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 23-MAY-2018, entry version 31. DE SubName: Full=Alpha-2-glycoprotein 1, zinc-binding {ECO:0000313|Ensembl:ENSPANP00000009027}; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSPANP00000009027}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000009027, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000009027, ECO:0000313|Proteomes:UP000028761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., RA Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., RA Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B., RA Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B., RA Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C., RA Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D., RA Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F., RA Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G., RA Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J., RA Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J., RA Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K., RA Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L., RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L., RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M., RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N., RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O., RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., RA Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., RA Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S., RA Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T., RA Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U., RA Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W., RA Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W., RA Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N., RA Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.; RT "Whole Genome Assembly of Papio anubis."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPANP00000009027} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHZZ02022050; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_003895810.1; XM_003895761.3. DR RefSeq; XP_017811709.1; XM_017956220.1. DR Ensembl; ENSPANT00000006214; ENSPANP00000009027; ENSPANG00000015855. DR GeneID; 100998476; -. DR CTD; 563; -. DR GeneTree; ENSGT00740000114936; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028761; Chromosome 3. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 298 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001921469. FT DOMAIN 207 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 298 AA; 34358 MW; E6979E7BF09DE38C CRC64; MVRMVPVLLS LLLFLGPAVP QETQDGRYSL TYIYTGLSKL VEDIPQFQAL GSLNDLQFFR YNSKDRKSQP VGLWREVEGM EDWKQDSQLQ KAREDIFMET LNDIVEYYND SNGSHNLHGR FGCEIENNRS SGSFWKYYYD GKDYIEFNKE IPAWVALDPA AQNTKQKWEA EPVYVQRAKA YLEEECPATL RKYLKYSKNI LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT RDGKVQEPEL RGEVLHNENG TYQSWVVVAV PPQDTAPYSC YVQHSSLAQP LVVPGEAR // ID A0A096NLG1_PAPAN Unreviewed; 348 AA. AC A0A096NLG1; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 23-MAY-2018, entry version 33. DE SubName: Full=Hemochromatosis {ECO:0000313|Ensembl:ENSPANP00000013819}; GN Name=HFE {ECO:0000313|Ensembl:ENSPANP00000013819}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000013819, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000013819, ECO:0000313|Proteomes:UP000028761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., RA Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., RA Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B., RA Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B., RA Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C., RA Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D., RA Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F., RA Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G., RA Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J., RA Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J., RA Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K., RA Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L., RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L., RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M., RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N., RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O., RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., RA Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., RA Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S., RA Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T., RA Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U., RA Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W., RA Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W., RA Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N., RA Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.; RT "Whole Genome Assembly of Papio anubis."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPANP00000013819} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHZZ02024302; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_003897211.1; XM_003897162.2. DR SMR; A0A096NLG1; -. DR Ensembl; ENSPANT00000007528; ENSPANP00000013819; ENSPANG00000021735. DR GeneID; 101016763; -. DR CTD; 3077; -. DR GeneTree; ENSGT00740000114936; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000028761; Chromosome 4. DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl. DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:Ensembl. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl. DR GO; GO:0030881; F:beta-2-microglobulin binding; IEA:Ensembl. DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl. DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0071281; P:cellular response to iron ion; IEA:Ensembl. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:Ensembl. DR GO; GO:1904283; P:negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:Ensembl. DR GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; IEA:Ensembl. DR GO; GO:1900121; P:negative regulation of receptor binding; IEA:Ensembl. DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; IEA:Ensembl. DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR GO; GO:1904434; P:positive regulation of ferrous iron binding; IEA:Ensembl. DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl. DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IEA:Ensembl. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; IEA:Ensembl. DR GO; GO:1900390; P:regulation of iron ion import; IEA:Ensembl. DR GO; GO:2000008; P:regulation of protein localization to cell surface; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 348 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001921956. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 348 AA; 40343 MW; 20ABB0A8EB7DF172 CRC64; MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGSSEQ DLGLSLFEAL GYVDDQLFVF YDHESRRVEP RTPWVSGRTS SQMWLQLSQS LKGWDHMFTV DFWTIMENHN HSKESHTLQV ILGCKMQEDN STEGFWKYGY DGQDHLEFCP DTLDWRAAEP RAWPTKLEWE RHKIRARQNR AYLERDCPVQ LQQLLELGRG VFDRPVPPLV KVTHHVTSSV TTLRCRALNY YPQNITMKWL KDRQPMDAKE VEPKDVLPNG DGTYQGWITL TVPPGEEQRY TCQVEHPGLD QPLLAFWEPS PSRTLVIGVI SGIAVFVIIL FIGMLFIILR KRQTSRGVMG HYVLAERE // ID A0A096NLP9_PAPAN Unreviewed; 343 AA. AC A0A096NLP9; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 23-MAY-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000013907}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000013907, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000013907, ECO:0000313|Proteomes:UP000028761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., RA Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., RA Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B., RA Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B., RA Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C., RA Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D., RA Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F., RA Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G., RA Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J., RA Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J., RA Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K., RA Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L., RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L., RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M., RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N., RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O., RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., RA Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., RA Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S., RA Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T., RA Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U., RA Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W., RA Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W., RA Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N., RA Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.; RT "Whole Genome Assembly of Papio anubis."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPANP00000013907} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHZZ02024339; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPANT00000015941; ENSPANP00000013907; ENSPANG00000007406. DR GeneTree; ENSGT00760000118960; -. DR OMA; GYCQEAY; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000028761; Chromosome 4. DR ExpressionAtlas; A0A096NLP9; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 343 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014160532. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 343 AA; 38593 MW; 7D00E543BF2CC5DB CRC64; MAVMAPRTLL LVLSGALALT QTRAGSHSMS YFYTSMSRPG RGEPRFFAVG YVDDTQFVRF DSDAASQRME PRAPWVEQEG PEYWDRSTRI MKTATQNAPV GLRNLRGYYN QSEAGSHTYQ SMYGCDLGPD GRLLRGYYQS AYDGRDYIAL NEDLRSWTAA DMAAQNTQRK WETEGVAEQL SAYLEGECLE WLRRHLENGK EMLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGKEQR YTCHVQHEGL REPLTLRWEP SSQSTIPIVG IIAGVVLLGI VVTGAVIAAV IWRRKSSGEE GDR // ID A0A096NLQ0_PAPAN Unreviewed; 361 AA. AC A0A096NLQ0; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 25-APR-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000013908}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000013908, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000013908, ECO:0000313|Proteomes:UP000028761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., RA Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., RA Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B., RA Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B., RA Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C., RA Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D., RA Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F., RA Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G., RA Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J., RA Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J., RA Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K., RA Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L., RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L., RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M., RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N., RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O., RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., RA Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., RA Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S., RA Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T., RA Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U., RA Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W., RA Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W., RA Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N., RA Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.; RT "Whole Genome Assembly of Papio anubis."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPANP00000013908} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHZZ02024339; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPANT00000015944; ENSPANP00000013908; ENSPANG00000004307. DR GeneTree; ENSGT00760000118960; -. DR OMA; TCVEWLC; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000028761; Chromosome 4. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 361 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014195370. FT TRANSMEM 296 320 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 186 283 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 361 AA; 40227 MW; B57790E52C9451B0 CRC64; MAPRTLLLLL SGTLALTETK AGSHSLRYFS TAVSRPGHGE PRFIAVGYMD DTQFVRFDSD AASPRMELRE WWMEQEGPEY WELQTLGAKA QAQTGSRTLQ EMFGCDVGPD GRLLRWYEQY AFDGKDYIAL NQDLRSWTAA DTAAQITQRK WEAANVAEQR RAYLEGTCVE WLCRHLETGK ETLQVPPRSP VDLLDSPKTH MTHHPVFDYE ATLRCWALGF YTAEITLTWQ WDGEDQTQDM ELLETRPAGD GTFQKWVAVV VPSGEEQRFT CHVQHEGLPK PLTLRWEPSL QPTSPIVVIV AGLVVLVAVI TGAVVAAVLW RKKSSGEEGV TGSQSAQGSH MSVTAYKGET LGGLMCAGCW G // ID A0A096NLS3_PAPAN Unreviewed; 324 AA. AC A0A096NLS3; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 28-MAR-2018, entry version 23. DE SubName: Full=Major histocompatibility complex, class I, E {ECO:0000313|Ensembl:ENSPANP00000013931}; GN Name=HLA-E {ECO:0000313|Ensembl:ENSPANP00000013931}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000013931, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000013931, ECO:0000313|Proteomes:UP000028761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., RA Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., RA Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B., RA Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B., RA Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C., RA Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D., RA Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F., RA Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G., RA Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J., RA Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J., RA Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K., RA Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L., RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L., RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M., RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N., RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O., RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., RA Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., RA Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S., RA Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T., RA Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U., RA Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W., RA Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W., RA Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N., RA Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.; RT "Whole Genome Assembly of Papio anubis."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPANP00000013931} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHZZ02024345; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPANT00000012351; ENSPANP00000013931; ENSPANG00000001215. DR GeneTree; ENSGT00760000118960; -. DR OMA; SALTKTW; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000028761; Chromosome 4. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 324 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014172949. SQ SEQUENCE 324 AA; 36773 MW; C97F9E532212F823 CRC64; MALGTLLLLL SALTKTWAGS HSLKYFHTSV SRPGRGGPRF ISVGYVDDTQ FVRYDSDAAS PRMEPRALWM EQEGPEYWDQ ETRSARDTAQ TFRVNLDTLR GYYNQSEAGS HTLQWMHGCD LGPDGRFLRG YEQFAYDGKD YLTLNEDLRS WSAVDTAAQI SEQKSNDGSE AEHQRAYLED TCVEWLRRYL ENGKETLQRS EPPKTHVTHH PVSDHEATLR CWALGFYPAE ITVTWQRDGE DQTQDTELVE TRPAGDGTFQ KWAAVVVPSG EEQRYTCHVQ HEGLPEPLTL RWGKEGNGRS CLLGKAGLGH WAVVAAVMWR RKSS // ID A0A096NPI4_PAPAN Unreviewed; 319 AA. AC A0A096NPI4; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 25-APR-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000014914}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000014914, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000014914, ECO:0000313|Proteomes:UP000028761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., RA Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., RA Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B., RA Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B., RA Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C., RA Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D., RA Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F., RA Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G., RA Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J., RA Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J., RA Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K., RA Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L., RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L., RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M., RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N., RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O., RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., RA Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., RA Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S., RA Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T., RA Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U., RA Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W., RA Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W., RA Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N., RA Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.; RT "Whole Genome Assembly of Papio anubis."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPANP00000014914} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHZZ02024379; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPANT00000005554; ENSPANP00000014914; ENSPANG00000012698. DR GeneTree; ENSGT00740000114936; -. DR OMA; CVPCCKK; -. DR OrthoDB; EOG091G0ANY; -. DR Proteomes; UP000028761; Chromosome 4. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}. FT DOMAIN 181 277 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 319 AA; 36279 MW; 40B4D08788FDA5CF CRC64; ILRYNVTVLS RDGSVQSGFL AEGHLDSQLF VRYDRQKRRA RPQGQWAEEV LGAKTWDTET GDLTENGKDL RRTLTHIEGQ KGGLHSLQEI KVCEIHEDNS TGGLRHFYYD GELFLSQNLE TQEWTELQSS RAQTLALNIR NFWKEDTMKT KTHYRAVQAD CLKKLQRYLE SGVAVRRTAP PMVNVTHSEA SEGNITVTCR ASSFYPRNIA LTWRQDGVSL NHDAQQWGYV LPDQNGTYQT WVATRIRQGE EQKFACYMEH SGNHSTHPVP SGEAGVTLER VRTLHPVEHL PVSLFSPELV SLRTLDQHPV GTGDHRDAT // ID A0A096NSR1_PAPAN Unreviewed; 339 AA. AC A0A096NSR1; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 23-MAY-2018, entry version 29. DE SubName: Full=MHC class I protein {ECO:0000313|EMBL:SCW24612.1}; GN Name=Paan-AG {ECO:0000313|EMBL:SCW24612.1}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000047270, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|EMBL:SCW24612.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=K22I {ECO:0000313|EMBL:SCW24612.1}; RA Otting N., Van der Wiel M.K.H., Doxiadis G.G.M., Bontrop R.E.; RT "New MHC class I alleles in Papio anubis."; RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPANP00000047270} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2018) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; LT622910; SCW24612.1; -; mRNA. DR UniGene; Pan.102; -. DR UniGene; Pan.18264; -. DR Ensembl; ENSPANT00000031161; ENSPANP00000025032; ENSPANG00000034965. DR Ensembl; ENSPANT00000048968; ENSPANP00000047270; ENSPANG00000034965. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000028761; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 339 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014505999. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 339 AA; 38667 MW; EF1BE6C2760AB7B2 CRC64; MAVMAPRTLL LVLSGVLALT QTRAGSHSMR YFYTAVSRPG RGQPRFIAVG YVDDTQFVRF DSDADSRRME PRAPWVEQEG PEYWDREAQN MKTATQTYRV NLRTLLRYYN QSQGGSHTVQ KMYGCDLGPD GRLLRGYEQY AYDGRDYIAL NEDLRSWTAA DMAAQNTQRK WEAEDVAEQH RIYLEGQCLE WLRRHLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEEHTQ DTELVETRPT GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSESTIPIVG IIAGLVLLGT VVTGAVVAAV MWRRKSSDR // ID A0A096NSR3_PAPAN Unreviewed; 365 AA. AC A0A096NSR3; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 20-JUN-2018, entry version 35. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:ALG03257.1}; DE SubName: Full=MHC class I protein {ECO:0000313|EMBL:SCW24598.1}; DE SubName: Full=Patr class I histocompatibility antigen, A-126 alpha chain-like precursor {ECO:0000313|Ensembl:ENSPANP00000041753}; GN Name=Paan-A {ECO:0000313|EMBL:ALG03257.1}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000041753, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|EMBL:ALG03257.1} RP NUCLEOTIDE SEQUENCE. RA Morgan R.A., Dudley D.D., O'Connor D.H.; RT "MHC class I full-length novel allele discovery in baboons."; RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:SCW24598.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=K93333BA {ECO:0000313|EMBL:SCW24598.1}; RA Otting N., Van der Wiel M.K.H., Doxiadis G.G.M., Bontrop R.E.; RT "New MHC class I alleles in Papio anubis."; RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPANP00000041753} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2018) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KR229932; ALG03257.1; -; mRNA. DR EMBL; LT622896; SCW24598.1; -; mRNA. DR UniGene; Pan.11149; -. DR Ensembl; ENSPANT00000033489; ENSPANP00000041753; ENSPANG00000032510. DR Ensembl; ENSPANT00000041983; ENSPANP00000031165; ENSPANG00000032510. DR GeneTree; ENSGT00760000118960; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000028761; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015031838. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 40885 MW; 53C739A7954DAE3C CRC64; MAVMAPRTLL LVLSGVLALT QTWAGSHSMR YFYTSMSRPG RGQPRFFAVG YVDDTQFVRF DSDAASQRME PRAPWVEQEG PEYWDRETQN MKAQTQNAPV NLRNLRGYYN QSEAGSHTLQ TMHGCDLGPD GRLLRGYYQS AYDGKDYFAL NEDLRSWTAA DLAAQNTQRK WEAADVAEQI RAYLEGRCVE WLRRYLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAV GFYPAEITLT WQRDGEDQTQ DTELMETRPA GDGTFQKWAA VVVPSGKEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IIAGLVLLGA MVIGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDVSL TACKV // ID A0A096NW06_PAPAN Unreviewed; 244 AA. AC A0A096NW06; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 19. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000017231}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000017231, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000017231, ECO:0000313|Proteomes:UP000028761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., RA Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., RA Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B., RA Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B., RA Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C., RA Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D., RA Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F., RA Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G., RA Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J., RA Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J., RA Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K., RA Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L., RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L., RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M., RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N., RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O., RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., RA Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., RA Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S., RA Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T., RA Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U., RA Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W., RA Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W., RA Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N., RA Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.; RT "Whole Genome Assembly of Papio anubis."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPANP00000017231} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHZZ02025576; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_009204163.1; XM_009205899.1. DR Ensembl; ENSPANT00000000142; ENSPANP00000017231; ENSPANG00000024446. DR GeneID; 103883952; -. DR GeneTree; ENSGT00390000003472; -. DR OMA; EANGHTH; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000028761; Chromosome 4. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 244 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001928755. FT TRANSMEM 222 242 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 43 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 244 AA; 27895 MW; 349CDCD2BD44085C CRC64; MAATASTAFL LCLSFLHLLS GWSGAGRAVK HCLSYDFIIT PKFRPEPQWC EVQGLVDERP FLHYDCVNHK AKAFASLGKK VNVTKTWEEQ TETLRDVVDF LKGQLPDIQV ENLMPIEPLI LQARMSCEHE AHGRGRGSWQ FLFNGQTFLL FDSNNRKWTA LHPGAKKMKE KWEKNTEVTM FFQKISMGDC KTWLEEFLMY WEQMLDPTKP PSLAQGTTHP KAMATTLIPW SLLIILLCFI LAGS // ID A0A096NW09_PAPAN Unreviewed; 245 AA. AC A0A096NW09; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 19. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000017234}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000017234, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000017234, ECO:0000313|Proteomes:UP000028761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., RA Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., RA Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B., RA Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B., RA Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C., RA Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D., RA Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F., RA Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G., RA Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J., RA Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J., RA Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K., RA Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L., RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L., RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M., RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N., RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O., RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., RA Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., RA Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S., RA Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T., RA Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U., RA Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W., RA Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W., RA Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N., RA Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.; RT "Whole Genome Assembly of Papio anubis."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPANP00000017234} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHZZ02025577; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_003898092.1; XM_003898043.3. DR Ensembl; ENSPANT00000014393; ENSPANP00000017234; ENSPANG00000023242. DR GeneTree; ENSGT00390000003472; -. DR OMA; CKMWLEE; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000028761; Chromosome 4. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 245 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001922888. FT TRANSMEM 227 244 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 44 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 245 AA; 27978 MW; 3FC316331648B387 CRC64; MAAAASTAFL LCLSFLHLLS GWSRAGRADT HCLCYDFIIT PKFRPEPRWC EVQGLVDERL FLHYDCVNHK AKAFASLGKK VNVTKTWEKQ TETLGDVVDF LKGQLPDIQV ENLMPIESLI LQARMSCEHE AHGRGRGSWQ FLFNGQTFLL FDSNNRKWTA LQPGAKKMKE KWEKNTEVTT FFQKISMGDC KTWLEEFLMY WEQMLDPTKP PTVAQGTTHP KAMATTLIPW SLLLIILLCF ILAGS // ID A0A096NW14_PAPAN Unreviewed; 246 AA. AC A0A096NW14; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 20-JUN-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000017239}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000017239, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000017239, ECO:0000313|Proteomes:UP000028761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., RA Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., RA Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B., RA Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B., RA Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C., RA Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D., RA Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F., RA Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G., RA Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J., RA Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J., RA Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K., RA Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L., RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L., RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M., RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N., RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O., RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., RA Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., RA Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S., RA Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T., RA Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U., RA Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W., RA Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W., RA Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N., RA Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.; RT "Whole Genome Assembly of Papio anubis."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPANP00000017239} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPANP00000047474} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2018) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHZZ02025577; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_009204158.1; XM_009205894.2. DR Ensembl; ENSPANT00000023721; ENSPANP00000017239; ENSPANG00000024481. DR Ensembl; ENSPANT00000044321; ENSPANP00000047474; ENSPANG00000024481. DR GeneID; 101017701; -. DR GeneTree; ENSGT00390000003472; -. DR Proteomes; UP000028761; Chromosome 4. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 246 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015031821. FT TRANSMEM 224 244 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 30 200 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 246 AA; 27493 MW; 1C4B28D346D711F6 CRC64; MAAAATIKIL LCLLLLLLPS LWSRAGRADL HSLCYEITII PKFRPGPRWC AIQGQVDKKT FLHYDCGNKT VTSISPLGKK LSVTKAWKAQ NPVLREVVDV LTEQLLDIQL ENYTPREPLT LQARVSCEQK AEGHSSGSWQ FGFDGQVFLL FDSENRMWTT VHPGARKMKE KWENDKDVTM SFHYISMGDC TRWLGDFLMD MDSTLEPSAG ASLTMSSGTT QLRATATTLI LCCLLIILCC FILAGI // ID A0A096NW15_PAPAN Unreviewed; 335 AA. AC A0A096NW15; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 23-MAY-2018, entry version 22. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000017240}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000017240, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000017240, ECO:0000313|Proteomes:UP000028761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., RA Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., RA Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B., RA Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B., RA Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C., RA Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D., RA Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F., RA Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G., RA Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J., RA Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J., RA Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K., RA Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L., RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L., RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M., RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N., RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O., RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., RA Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., RA Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S., RA Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T., RA Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U., RA Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W., RA Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W., RA Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N., RA Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.; RT "Whole Genome Assembly of Papio anubis."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPANP00000017240} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHZZ02025577; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPANT00000004055; ENSPANP00000017240; ENSPANG00000023895. DR GeneTree; ENSGT00390000003472; -. DR OMA; YEITIIP; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000028761; Chromosome 4. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 335 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014167476. FT DOMAIN 31 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 335 AA; 37228 MW; E1D3EA60A3A33B48 CRC64; MAAAASPAFL LRLPLLFLLS VWCRTGRADP HSLCYGITII PKFRPGPRWC AVEGQVDKKT FLHYDCGNKT VTPVSPLGKK LNVTKAWKAQ NTVLREVVDM LTQQLLDIQL ENYTPREPLT LQARMSCEQK AEGHSSGSWQ FSFDGQVFLL FDSENRMWTT VHPGARKMKE KWENDKDVTM SFRYISMGDC TRWLGDFLTG MDSTLEPSAG APPTMSSGAA QLRATATTLI LCCLLLMCLL MCSRHSPTHS HGHHPQSLEP PPHPPLLHPP WLLRRVLWSD SYQIGKDPLS GGHVTRVTLP IIGDDSHSLP CPLPLYTINN GAARHSGPLP ASASW // ID A0A096NW16_PAPAN Unreviewed; 196 AA. AC A0A096NW16; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 28-MAR-2018, entry version 16. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000017241}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000017241, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000017241, ECO:0000313|Proteomes:UP000028761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., RA Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., RA Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B., RA Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B., RA Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C., RA Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D., RA Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F., RA Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G., RA Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J., RA Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J., RA Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K., RA Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L., RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L., RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M., RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N., RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O., RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., RA Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., RA Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S., RA Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T., RA Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U., RA Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W., RA Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W., RA Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N., RA Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.; RT "Whole Genome Assembly of Papio anubis."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPANP00000017241} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHZZ02025576; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPANT00000016840; ENSPANP00000017241; ENSPANG00000030194. DR GeneTree; ENSGT00390000003472; -. DR OMA; QIAKRPL; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000028761; Chromosome 4. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 196 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014134209. FT DOMAIN 25 167 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 196 AA; 22039 MW; 65BFB6DD126DDB5C CRC64; CDGSQVPMVR GLLSLLLLLS GICDPHSLCY DITIIPKFRP GPQWYAVQDQ VGKKTFLHYD CGNKTVTPVS PLGKKLNVTK AWKAQNPVLR EVVDMLTEQL LDIQLENYIP REPLTLQARM SCEQKAEGHS SGSWQFGFDG QVFLLFDSEN RMWTTVHPGA RKMKENTLEP SAGGNRRKRN GDLKWVSLGE AQKKAI // ID A0A096NWZ2_PAPAN Unreviewed; 249 AA. AC A0A096NWZ2; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 23. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000017582}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000017582, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000017582, ECO:0000313|Proteomes:UP000028761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., RA Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., RA Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B., RA Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B., RA Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C., RA Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D., RA Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F., RA Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G., RA Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J., RA Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J., RA Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K., RA Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L., RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L., RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M., RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N., RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O., RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., RA Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., RA Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S., RA Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T., RA Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U., RA Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W., RA Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W., RA Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N., RA Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.; RT "Whole Genome Assembly of Papio anubis."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPANP00000017582} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHZZ02025576; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_009204153.1; XM_009205889.2. DR Ensembl; ENSPANT00000005794; ENSPANP00000017582; ENSPANG00000006926. DR GeneTree; ENSGT00390000003472; -. DR OMA; WGKQLEM; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000028761; Chromosome 4. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 249 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001922357. FT DOMAIN 42 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 249 AA; 28136 MW; B99C3B84DA99FA48 CRC64; MAVAASPAIL LCLLTLYLLS DWSGTGRADA HSLWYNFNIT HGQQWCEVQG QADEKNFLSY DCGSDKVLSM GHLEEQLDVT DAWGKQLEML KEVGRRLRMK LADNKLEDFT PSGPLTLQAR MSCECEVDGP IRGSWQFSFN GQKFLLFDSN NRKWTVVQAG ARQMKEKWED SELTMFFQKI SMGDCKTWLR DFLMHRKRRL EPTAPPTVAP GTAQTKAMAT SLSPWSLLII LCFTLPGILG ESFRVTGGR // ID Q30869_PAPAN Unreviewed; 365 AA. AC Q30869; A0A096NX00; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 18-JUL-2018, entry version 123. DE SubName: Full=MHC class I A {ECO:0000313|EMBL:AAB04174.1}; DE SubName: Full=MHC class I protein {ECO:0000313|EMBL:SIP56221.1}; GN Name=MHC-A {ECO:0000313|EMBL:SIP56221.1}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|EMBL:AAB04174.1}; RN [1] {ECO:0000313|EMBL:AAB04174.1} RP NUCLEOTIDE SEQUENCE. RA Prilliman K.R., Hildebrand W.H., Lawlor D., Kennedy R., Ellexson M.; RL Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AAB04174.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=8623205; DOI=10.1097/00007890-199604150-00001; RA Prilliman K., Lawlor D., Ellexson M., McElwee N., Confer D., RA Cooper D.K., Kennedy R.C., Hildebrand W.; RT "Characterization of baboon class I major histocompatibility RT molecules. Implications for baboon-to-human xenotransplantation."; RL Transplantation 61:989-996(1996). RN [3] {ECO:0000313|Ensembl:ENSPANP00000017590, ECO:0000313|Proteomes:UP000028761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., RA Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., RA Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B., RA Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B., RA Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C., RA Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D., RA Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F., RA Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G., RA Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J., RA Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J., RA Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K., RA Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L., RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L., RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M., RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N., RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O., RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., RA Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., RA Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S., RA Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T., RA Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U., RA Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W., RA Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W., RA Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N., RA Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.; RT "Whole Genome Assembly of Papio anubis."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSPANP00000017590} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:SIP56221.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BA001 {ECO:0000313|EMBL:SIP56221.1}; RA Jaros S., Januszkiewicz K., Wedrychowicz H.; RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:SIP56221.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BA001 {ECO:0000313|EMBL:SIP56221.1}; RA Bussan H., Wiseman R.; RT "Paan MHC class I sequences."; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHZZ02024339; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; U35625; AAB04174.1; -; mRNA. DR EMBL; LT673797; SIP56221.1; -; mRNA. DR UniGene; Pan.102; -. DR ProteinModelPortal; Q30869; -. DR Ensembl; ENSPANT00000005551; ENSPANP00000017590; ENSPANG00000007406. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR OMA; SHEACKE; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000028761; Chromosome 4. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015297432. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 40608 MW; B0C575AAEADDF240 CRC64; MAVMAPRTLL LVLSGALALT QTRAGSHSMS YFYTSMSRPG RGEPRFFAVG YVDDTQFVRF DSDAASQRME PRAPWVEQEG PEYWDRSTRI MKTATQNAPV GLRNLRGYYN QSEAGSHTYQ SMYGCDLGPD GRLLRGYYQS AYDGRDYIAL NEDLRSWTAA DMAAQNTQRK WETEGVAEQL SAYLEGECLE WLRRHLENGK EMLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGKEQR YTCHVQHEGL REPLTLRWEP SSQSTIPIVG IIAGVVLLGI VVTGAVIAAV IWRRKSSDGK GGSYSQAASS DSAQGSDVSL TACKV // ID A0A096NZZ3_PAPAN Unreviewed; 232 AA. AC A0A096NZZ3; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 25-APR-2018, entry version 18. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000018668}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000018668, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000018668, ECO:0000313|Proteomes:UP000028761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., RA Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., RA Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B., RA Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B., RA Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C., RA Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D., RA Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F., RA Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G., RA Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J., RA Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J., RA Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K., RA Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L., RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L., RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M., RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N., RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O., RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., RA Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., RA Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S., RA Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T., RA Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U., RA Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W., RA Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W., RA Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N., RA Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.; RT "Whole Genome Assembly of Papio anubis."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPANP00000018668} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHZZ02025576; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPANT00000026292; ENSPANP00000018668; ENSPANG00000013265. DR GeneTree; ENSGT00390000003472; -. DR OMA; NISMGDC; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000028761; Chromosome 4. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 232 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014138385. FT DOMAIN 23 192 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 232 AA; 25938 MW; BE582C3762A5F54B CRC64; VVAGASPAFL LCLHLCSCCP PDPHSLCYDI TIIPKFRPGP RWCAVQGQVD KKTFLHYDCG NKTVTPVSTL GKKLNVTKAW KAQNPVLREV VDMLTEQLLD ILLENYTPRE PLTLQTRMSC EQKAEGHSSG SWQFSFDGQV FLLFDSENRM WTTVHPGARK MKEKWQNDKD VTMSFRYISM GDCTRWLGDF LAGMGRTLEP SAGGTAQPTA MATTLSPWSL LLIFPCFILP GC // ID A0A096P596_PAPAN Unreviewed; 299 AA. AC A0A096P596; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 20-JUN-2018, entry version 26. DE SubName: Full=Patr class I histocompatibility antigen, A-126 alpha chain-like precursor {ECO:0000313|Ensembl:ENSPANP00000020521}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000020521, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000020521} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSPANT00000004054; ENSPANP00000020521; ENSPANG00000032510. DR GeneTree; ENSGT00760000118960; -. DR OMA; WDRNTRN; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000028761; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 299 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014136983. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 299 AA; 34265 MW; DF826C9BB03A219B CRC64; MAVMAPRTLL LVLSGVLALT QTWAGSHSMR YFYTSMSRPG RGQPRFFAVG YVDDTQFVRF DSDAASQRME PRAPWVEQEG PEYWDRETQN MKAQTQNAPV NLRNLRGYYN QSEAGSHTLQ TMHGCDLGPD GRLLRGYYQS AYDGKDYFAL NEDLRSWTAA DLAAQNTQRK WEAADVAEQI RAYLEGRCVE WLRRYLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAV GFYPAEITLT WQRDGEDQTQ DTELMETRPA GDGTFQKWAA VVVPSGKEQR YTCHVQHEGL PKPLTLRWV // ID A0A096P5C4_PAPAN Unreviewed; 359 AA. AC A0A096P5C4; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 20-JUN-2018, entry version 35. DE SubName: Full=HLA class I histocompatibility antigen, B-27 alpha chain precursor {ECO:0000313|Ensembl:ENSPANP00000020549}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000020549, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000020549} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSPANT00000004682; ENSPANP00000020549; ENSPANG00000030071. DR GeneTree; ENSGT00760000118960; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000028761; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 359 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014118859. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 40353 MW; B612669DC0182913 CRC64; MAPRTLLLLL SGALALTETW AGSHSLRYFH TAVSRPGRWE PRFISVGYVD DTQFVRFDSD AESPREEPRA PWMEQEGPEY WEEQTRIAKA NAQTHRGNLR TLRGYYNQSE GGSHTLQMMH GCDLGPDGRL LRGYHQQAYD GKDYIALNED LRSWTAADMA AQNTQRKWEG DRYAERFRAY LEGECLEWLR RYLQNGKETL QRADPPKTHV THHPVSDHEA TLRCWALGFY PAEITLTWQR DGEDQTQDIE FVETRPGGDG TFQKWGAVVV PSGEEQRYTC HVQHEGLPEP LTLRWEPSSQ STIPIVGIVV GLAVLAVVVT GAVVAAVMWR RKSSGGKGGS YSQAASNDSA QGSDVSLMA // ID A0A099Z4T2_TINGU Unreviewed; 223 AA. AC A0A099Z4T2; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 07-JAN-2015, sequence version 1. DT 23-MAY-2018, entry version 16. DE SubName: Full=Endothelial protein C receptor {ECO:0000313|EMBL:KGL75810.1}; GN ORFNames=N309_09016 {ECO:0000313|EMBL:KGL75810.1}; OS Tinamus guttatus (White-throated tinamou). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Palaeognathae; Tinamiformes; Tinamidae; Tinamus. OX NCBI_TaxID=94827 {ECO:0000313|EMBL:KGL75810.1, ECO:0000313|Proteomes:UP000053641}; RN [1] {ECO:0000313|EMBL:KGL75810.1, ECO:0000313|Proteomes:UP000053641} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N309 {ECO:0000313|EMBL:KGL75810.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KL888345; KGL75810.1; -; Genomic_DNA. DR RefSeq; XP_010210795.1; XM_010212493.1. DR GeneID; 104565771; -. DR CTD; 10544; -. DR Proteomes; UP000053641; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR015669; Endothetial_C_recpt. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR PANTHER; PTHR15349; PTHR15349; 1. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053641}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KGL75810.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053641}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 223 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001965859. FT TRANSMEM 197 218 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 66 181 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 223 AA; 24738 MW; A7D9E84D482BE181 CRC64; MLVLLLLCAA LACGAEQAAP LAFTMLQVTR VSNGRSSFWG NATLGGRPSH RLEGHSLSQL LPLEPPATWA RRKEDVATYL DYFANMVKLI HMERNIEYTQ ILRCRLGCHL FPNGTARSFY DMTLNSTAFL TFHVPTATWE CRWPRQDAVA TFTHQQLMKY PETTRDLQHF LNTTCVDVLR AQSAETEKQS GRSHTPLVVG LTFGALALVA MAAGIFLCTG GSC // ID A0A0A0A0Z5_CHAVO Unreviewed; 183 AA. AC A0A0A0A0Z5; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 07-JAN-2015, sequence version 1. DT 25-OCT-2017, entry version 14. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain {ECO:0000313|EMBL:KGL87058.1}; DE Flags: Fragment; GN ORFNames=N301_04064 {ECO:0000313|EMBL:KGL87058.1}; OS Charadrius vociferus (Killdeer) (Aegialitis vocifera). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; OC Charadrius. OX NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL87058.1, ECO:0000313|Proteomes:UP000053858}; RN [1] {ECO:0000313|EMBL:KGL87058.1, ECO:0000313|Proteomes:UP000053858} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL87058.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KL870173; KGL87058.1; -; Genomic_DNA. DR Proteomes; UP000053858; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053858}; KW Reference proteome {ECO:0000313|Proteomes:UP000053858}. FT DOMAIN 94 174 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:KGL87058.1}. FT NON_TER 183 183 {ECO:0000313|EMBL:KGL87058.1}. SQ SEQUENCE 183 AA; 21111 MW; BD00F5E5F19B4A6C CRC64; GAQTRQRMSG CDLLEDGSTR GYYQSAYDGR DFIAFDMDTM TFTAADTAAQ ITKRKWEEDG TVAEQLKHYL QITCIEWLRK YVSYGRAVLE RKEPPMVRVS GKEAYGTLTL RCRAYGFYPR PITVSWLKDG EVRDQETEWG SIVPNSDGTY YTWASIDALP EEKDKYRCRV EHASLPEPVL YAW // ID A0A0A0MV07_PAPAN Unreviewed; 365 AA. AC A0A0A0MV07; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 07-JAN-2015, sequence version 1. DT 28-MAR-2018, entry version 27. DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSPANP00000004693}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSPANP00000004693}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000004693, ECO:0000313|Proteomes:UP000028761}; RN [1] {ECO:0000313|Ensembl:ENSPANP00000004693, ECO:0000313|Proteomes:UP000028761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., RA Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., RA Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B., RA Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B., RA Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C., RA Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D., RA Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F., RA Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G., RA Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J., RA Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J., RA Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K., RA Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L., RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L., RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M., RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N., RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O., RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., RA Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., RA Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S., RA Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T., RA Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U., RA Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W., RA Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W., RA Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N., RA Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.; RT "Whole Genome Assembly of Papio anubis."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPANP00000004693} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHZZ02014691; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AHZZ02014692; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AHZZ02014693; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_009193240.2; XM_009194976.2. DR RefSeq; XP_009193241.2; XM_009194977.2. DR RefSeq; XP_009193243.2; XM_009194979.2. DR Ensembl; ENSPANT00000002480; ENSPANP00000004693; ENSPANG00000012030. DR GeneID; 101009991; -. DR CTD; 2217; -. DR GeneTree; ENSGT00740000114936; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR Proteomes; UP000028761; Chromosome 19. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019864; F:IgG binding; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001967197. FT TRANSMEM 298 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 39932 MW; 0734B97C28A899C7 CRC64; MRVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGMPAFWVS GWLGPQQYLS YDSLRGQAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE AFKALGGKGP YTLQGLLGCE LSPDNTSVPT AKFALNGEEF MNFDLKQGTW GGDWPEALAI SQRWQQQDKA ANKELTFLLF SCPHRLREHL ERGRGNLEWK EPPSMRLKAR PGNPGFSVLT CSAFSFYPPE LQLRFLRNGL AAGTGQGDFG PNSDGSFHAS SSLIVKSGDE HHYCCIVQHA GLAQPLRVEL ETPAKSSVLV VGIVIGVLLL TAAAVGGALL WRRMRSGLPA PWISLRGDDT GSLLPTPGEA QDADSKDINV IPTTA // ID A0A0A6YWB2_MOUSE Unreviewed; 89 AA. AC A0A0A6YWB2; DT 04-FEB-2015, integrated into UniProtKB/TrEMBL. DT 04-FEB-2015, sequence version 1. DT 12-SEP-2018, entry version 23. DE SubName: Full=Major histocompatibility complex class I-related gene protein {ECO:0000313|Ensembl:ENSMUSP00000141476}; GN Name=Mr1 {ECO:0000313|Ensembl:ENSMUSP00000141476, GN ECO:0000313|MGI:MGI:1195463}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000141476, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000141476, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000141476, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000141476} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000141476}; RG Ensembl; RL Submitted (DEC-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC140038; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; A0A0A6YWB2; -. DR Ensembl; ENSMUST00000192410; ENSMUSP00000141476; ENSMUSG00000026471. DR MGI; MGI:1195463; Mr1. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000000589; Chromosome 1. DR Bgee; ENSMUSG00000026471; Expressed in 197 organ(s), highest expression level in thymus. DR ExpressionAtlas; A0A0A6YWB2; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|MaxQB:A0A0A6YWB2, KW ECO:0000213|PeptideAtlas:A0A0A6YWB2}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 89 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002034075. FT DOMAIN 20 82 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 89 AA; 10280 MW; 763460097BC6D302 CRC64; MMLLLPLLAV FLVKRSHTRT HSLRYFRLAV SDPGPVVPEF ISVGYVDSHP ITTYDSVTRQ KEPKAPWMAE NLAPDHWERA SHLPENDWL // ID A0A0B4J192_BOVIN Unreviewed; 315 AA. AC A0A0B4J192; DT 04-MAR-2015, integrated into UniProtKB/TrEMBL. DT 04-MAR-2015, sequence version 1. DT 12-SEP-2018, entry version 26. DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSBTAP00000031824}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSBTAP00000031824, GN ECO:0000313|VGNC:VGNC:28934}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000031824, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000031824, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000031824, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000031824} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000031824}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02047478; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005219234.1; XM_005219177.2. DR UniGene; Bt.1035; -. DR Ensembl; ENSBTAT00000031878; ENSBTAP00000031824; ENSBTAG00000013926. DR GeneID; 338062; -. DR CTD; 2217; -. DR VGNC; VGNC:28934; FCGRT. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000009136; Chromosome 18. DR Bgee; ENSBTAG00000013926; Expressed in 9 organ(s), highest expression level in liver. DR ExpressionAtlas; A0A0B4J192; baseline and differential. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 315 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002106969. FT DOMAIN 201 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 315 AA; 35045 MW; 2FB71C4EC0FEC4AE CRC64; MRLPRPQPWG LGLLLVLLPG ALSAENYRSL QYHFTAVSAP AAGTPAFWVS GWLGPQQYLS YNNLRAQAEP YGAWVWESQV SWYWEKETMD LRNQETLFLE ALQALGEGPF TMQGLLGCEL GPDNVSVPVA KFALNGEEFM MFDPKLGIWD GDWPESRTVS IKWTQQPEAV NKEKTFLLYS CPHRLLGHLE RGRGNLEWKE PPSMRLKARP GSPGFSVLTC SAFSFYPPEL KLRFLRNGLA IGSGEIDMGP NGDGSFYAWS SLTVKSGDEH HYRCVVQHAG LAQPLTVELA PWISFRGEDV GALLPTPGLS KDGES // ID A0A0D9R6C0_CHLSB Unreviewed; 300 AA. AC A0A0D9R6C0; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 23-MAY-2018, entry version 23. DE SubName: Full=Hemochromatosis {ECO:0000313|Ensembl:ENSCSAP00000004159}; GN Name=HFE {ECO:0000313|Ensembl:ENSCSAP00000004159}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004159, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004159, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004159} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AQIB01159582; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000005947; ENSCSAP00000004159; ENSCSAG00000007897. DR GeneTree; ENSGT00740000114936; -. DR OMA; ITMKWLK; -. DR Proteomes; UP000029965; Chromosome 17. DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl. DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:Ensembl. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl. DR GO; GO:0030881; F:beta-2-microglobulin binding; IEA:Ensembl. DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl. DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0071281; P:cellular response to iron ion; IEA:Ensembl. DR GO; GO:0042446; P:hormone biosynthetic process; IEA:Ensembl. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:Ensembl. DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IEA:Ensembl. DR GO; GO:1904283; P:negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:Ensembl. DR GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; IEA:Ensembl. DR GO; GO:1900121; P:negative regulation of receptor binding; IEA:Ensembl. DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; IEA:Ensembl. DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR GO; GO:1904434; P:positive regulation of ferrous iron binding; IEA:Ensembl. DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl. DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl. DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IEA:Ensembl. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; IEA:Ensembl. DR GO; GO:1900390; P:regulation of iron ion import; IEA:Ensembl. DR GO; GO:2000008; P:regulation of protein localization to cell surface; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 257 281 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 154 238 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 300 AA; 35005 MW; 5C3DA06084D19646 CRC64; MGSSEQDLGL SLFEALGYVD DQLFVFYDHE SRRVEPRTPW VSGRTSSQMW LQLSQSLKGW DHMFTVDFWT IMENHNHSKE SHTLQVILGC KMQEDNSTEG FWKYGYDGQD HLEFCPDTLD WKAAEPRAWP TKLEWERHKI RARQNRAYLE RDCPVQLQQL LELGRGVFDR PVTTLRCRAL NYYPQNITMK WLKDRQPMDA KEVERKDVLP NGDGTYQGWI TLTVPPGEEQ RYTCQVEHPG LDQPLLAFWE PSPSRTLVIG VISGIAVFVI ILFIGILFII LRKRQTSRGV MGHYVLAERE // ID A0A0D9R6V6_CHLSB Unreviewed; 348 AA. AC A0A0D9R6V6; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 19. DE SubName: Full=Major histocompatibility complex, class I, F {ECO:0000313|Ensembl:ENSCSAP00000004345}; GN Name=HLA-F {ECO:0000313|Ensembl:ENSCSAP00000004345}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004345, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004345, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004345} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC241602; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000006136; ENSCSAP00000004345; ENSCSAG00000008083. DR GeneTree; ENSGT00760000118960; -. DR OMA; RITQRFY; -. DR Proteomes; UP000029965; Chromosome 17. DR GO; GO:0009986; C:cell surface; IEA:Ensembl. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0046978; F:TAP1 binding; IEA:Ensembl. DR GO; GO:0046979; F:TAP2 binding; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 348 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002344666. FT TRANSMEM 307 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 348 AA; 39287 MW; 39E7ABC0F05A8FAB CRC64; MAPRTLLLVL SGALALTETW AGSHSLRYFS TAVSRPGHRE PRYRYIAVEY VDDTQFLRFD SDAAIPRMEP RAPWVEQEGP QYWERTTGYA KANARTDRVA LGKLLLQYNQ SEAGSHTLQG MNGCDMGPDG RLLRGYHQHA YDGKDYISLN EDLRSWTAAD TVARITQRFY EADGYAEEIR TYLEGECLEL LRRYLENGKE TLQRADPPKA HVAHHPISDR EATLRCWALG FYPAEITLTW QRDGEEQTQD TELVETRPAG DGTFQKWAAV VVPSGEEQRY TCYVQHEGLP QLLTLRWESS SQPTIPIVGI VAGLAVLAVV VTGAMVAAVM WRRKSSDRNR GSYSQPAM // ID A0A0D9R6W4_CHLSB Unreviewed; 381 AA. AC A0A0D9R6W4; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 18. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000004353}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004353, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004353, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004353} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC241602; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000006144; ENSCSAP00000004353; ENSCSAG00000008089. DR GeneTree; ENSGT00760000118960; -. DR OMA; QPRFIAV; -. DR Proteomes; UP000029965; Chromosome 17. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 381 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002344670. FT TRANSMEM 322 348 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 225 313 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 381 AA; 42949 MW; 7B15BF8C46E449CF CRC64; MAVMAPRTLL LVLSGVLALT QTRAGSHSMR YFYTSVSRPG RGQPRFIAVG YVDDTQFVRF DSDAVGYVDD TQFVRFDSDA ASQRMEPRAP WVEQEGPEYW DRETQNMKTA TQTYRENLRT LLRYYNQSEA GSHTVQKMYG CDLGPDGRLL RGYEQFAYDG RDYIALNEDL RSWTAADTAA QNTQRKWEAA GVAEQHRTYL EGECLEWLRR YLENGKETLQ RADPPKTHVT HHPVSDYEAT LRCWALGFYP AEIALTWQRD GEEQTQDTEL VETRPTGDGT FQKWAAVVVP AGEEQRYTCH VQHEGLPEPL TLRWEPSFQS TILIVGIIAG LVLLGTVVTG AVVAAVMWRR KSSDRKGGSY SQAASSDSAQ GSDVSLTAYK V // ID A0A0D9R735_CHLSB Unreviewed; 235 AA. AC A0A0D9R735; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 17. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000004424}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004424, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004424, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004424} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC241845; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000006220; ENSCSAP00000004424; ENSCSAG00000008166. DR GeneTree; ENSGT00760000118960; -. DR OMA; SHEACKE; -. DR Proteomes; UP000029965; Chromosome 17. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 181 202 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 84 172 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 235 AA; 26380 MW; AAC397740CFA4686 CRC64; TCRPCAATTT RARPFAYDGK DYLTLNEDLR SWSAVDTVAQ ISERKLNDGS EAEHQRAYLE DTCVEWLRRY LENGKETLQR PDPPKTHVTH YPVSDHEATL RCWALGFYPA EITVTWQRDG EDQTQDTELV ETRPAGDGTF QKWAAVVVPS GEEQRYTCHV QHEGLPEPLT LRWEPPSQHS IPIVAIIAGL VLLGAVVAAV MWRRKSSGRK GWSYSQASCS DSAQGSDESL TAYKT // ID A0A0D9R742_CHLSB Unreviewed; 359 AA. AC A0A0D9R742; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 20-JUN-2018, entry version 21. DE SubName: Full=Major histocompatibility complex, class I, E {ECO:0000313|Ensembl:ENSCSAP00000004431}; GN Name=HLA-E {ECO:0000313|Ensembl:ENSCSAP00000004431}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004431, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004431, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004431} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC241845; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000006224; ENSCSAP00000004431; ENSCSAG00000008172. DR GeneTree; ENSGT00760000118960; -. DR OMA; SALTKTW; -. DR Proteomes; UP000029965; Chromosome 17. DR ExpressionAtlas; A0A0D9R742; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 359 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002345034. FT TRANSMEM 302 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 203 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 40187 MW; E3CB8E784C9B98B0 CRC64; MALGTLLLLL SALTKTWAGS HSLKYFHTSV SRPGRGEPRF ISVGYVDDTQ FVRFDSDAAS PRMQPRAPWV EQEGPEYWDQ ETRSARDTAQ TFRVNLNTLR GYYNQSEAGS HTLQWMHGCD LGPDGRFLRG YEQFAYDGKD YLTLNEDLRS WSAVDTAAQI SEQKSNDGSE AEHQRAYLED TCVEWLRRYL ENGKETLQRS EPPKTHVTHH PVSDHEATLR CWALGFYPAE ITVTWQRDGE DQTQDMELVE TRPAGDGTFQ KWAAVVVPSG EEQRYTCHVQ HEGLPEPLTL RWEPSSQSTI PIVGIISCLF LLGAVVTGAV VAAVMWRRKS SGRKGGSYSQ AECGDSAQGS DVSLTACKA // ID A0A0D9R7U3_CHLSB Unreviewed; 391 AA. AC A0A0D9R7U3; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 17. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000004682}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004682, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004682, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004682} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC241498; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC241509; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000006479; ENSCSAP00000004682; ENSCSAG00000008426. DR GeneTree; ENSGT00760000118960; -. DR OMA; MKNATQT; -. DR Proteomes; UP000029965; Chromosome 17. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 391 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002344573. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 391 AA; 43846 MW; 085CF0633A6F68DE CRC64; MRVMAPRTLL LLLSGALALT ETWAGSHSLR YFTTALSRPG RGEPRFISVG YVDDTQFVRF DSNAESPRME PRARWIEQEG PEYWEEETRR AKGNAQTDLG GLGILRGYYN QSEAGSHTYQ RMSGCDLGPD GRLLRGYYQR AYEGKDYIAL NEDLRSWTAA DMAAQNTQRK WEAARKAERF RAYLEGECVE WLRRYLEYGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPG GDGTFQKWGA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQSTIPIVG IVAGLAVLGA VFTGAVVAAV MWRRKSSGGK GGSYSQAACK WWGWECGGAH PSRNSSCPMS PAGSDQLLFL FYSSQRQCSG L // ID A0A0D9R7V4_CHLSB Unreviewed; 362 AA. AC A0A0D9R7V4; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 17. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000004693}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004693, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004693, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004693} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AQIB01159685; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159686; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159687; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159688; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159689; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159690; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159691; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159692; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159693; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159694; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000006491; ENSCSAP00000004693; ENSCSAG00000008434. DR GeneTree; ENSGT00760000118960; -. DR OMA; HIFQRIH; -. DR Proteomes; UP000029965; Chromosome 17. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002344575. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40638 MW; D8F0E7097E80894B CRC64; MQVMAPRTLL LLLSGTLALT ETWAGSHSLR YFHTAVSRPG RWEPHFISVG YVDDTQFVRF DSDAASPREE PRAPWMEQEG PEYWEEQTRN AEAHAQSHRV SLRNLRGYYN QSEWGSHTLQ KMYGCDLGPD GRLLRGYEQF AYDGRDYIAL NEDLRSWTAT DMAAQNTQRK WEAARAAEKL RAYLEGTCLE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWGA VVVPSGEEQR YTCHVQHKGL LEPLTLRWEP SSQSTIPIVG IVAALAVLAV VVTGAVVAAV MWRKKSSGGK GGSYSQAASN DSAQGSDVSL TA // ID A0A0D9R7W0_CHLSB Unreviewed; 364 AA. AC A0A0D9R7W0; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 17. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000004699}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004699, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004699, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004699} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AQIB01159694; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159695; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159696; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159697; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000006497; ENSCSAP00000004699; ENSCSAG00000008447. DR GeneTree; ENSGT00760000118960; -. DR OMA; RREPWYL; -. DR Proteomes; UP000029965; Chromosome 17. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002344717. FT TRANSMEM 309 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 212 300 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 40967 MW; 09AFC0BA7A080435 CRC64; MHRVRVMMPG TVLLLLSGAL ALTETWAGSH SMRYFSTAVS RPGRREPWYL AVGYVDDTQF VWFDSDAESP RMEPRAPWIE QEEPEYWEEQ TRRAKGNAQA DRGNLRTLLR YYNQSEGGSH TFQWMYGCDL GPDGRLLRGY HQSAYDGKDY IALNEDLRSW TAADMAAGFT QRKWEAARAA ERFRAYLEGE CLEWLRRHLE NGKETLQRAE PPKTHVTHHP ISDHEATLRC WALGFYPAEI TLTWQRDGED QTQDTELVET RPGGDGTFQK WGAVVVPSGE EQRYTCHVQH EGLTEPLTLR WEPSSQSTIP IVGIVAGLAV LAVVFIGAVV AAMMRKKCSG GKGGSYSQAA SKDSSQGSDE SLMA // ID A0A0D9R7Z2_CHLSB Unreviewed; 293 AA. AC A0A0D9R7Z2; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 18. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000004731}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004731, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004731, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004731} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AQIB01159691; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159692; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159693; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159694; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159695; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159696; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159697; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159698; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159699; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159700; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000006528; ENSCSAP00000004731; ENSCSAG00000008475. DR GeneTree; ENSGT00760000118960; -. DR OMA; WDRNTRN; -. DR Proteomes; UP000029965; Chromosome 17. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 238 263 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 141 229 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 293 AA; 32948 MW; F2E8722FE4F677CB CRC64; MEPRAPWMEQ EGPEYWDRNT RNAKVNAETF RGDLRNLLRY YNQSEAGSHT FQWMYGCDLG PDGRLLRGYR QFAYDGKDYI ALNEDLRSWT AADTTAQITQ RKWEAARAAA KLRAYLEGEC LEWLRRYLEN GKETLQHADP PKTHVTHHPV SDHEATLRCW ALGFYPAEIT LTWQRDGEEQ TQDTELVETR PAGDGTYQKW GAVVVPSGEE QRYTCHVQHE GLRQPLTLRW EPSSQSTIPI VGIVAGLAVL AVITGAVVAA VMWRRKNSGG KGGSYSQAAS SDSAQGSDVS LTA // ID A0A0D9R800_CHLSB Unreviewed; 405 AA. AC A0A0D9R800; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 18. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000004739}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004739, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004739, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004739} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC241846; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159731; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159732; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159733; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159734; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159735; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159736; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159737; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159738; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01159739; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000006536; ENSCSAP00000004739; ENSCSAG00000008482. DR GeneTree; ENSGT00760000118960; -. DR OMA; TESWIAP; -. DR Proteomes; UP000029965; Chromosome 17. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 351 375 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 252 340 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 405 AA; 45027 MW; B7DB55DD895E63E4 CRC64; MTRRQCSLPL GVGFREQPIS VATVPGFKVP ADTRRLRVST DAKDGILAPR TLFLLLSGAL ALTETWAGSH SLRYFSTSVS RPGRWEPHFI SVGYVDDTQF VRFDSDAESP REEPRAPWVE QEGPEYWDRN TRIAKGHAQT DRRNLRTLLR YYNQSEWGSH TVQRMYGCDL GPDGRLLRGY DQSAYDGKDY IALNEDLRSW TAADMAAQST QRKWEAAGTA EQLRAYLEGT CVEWLRRYLE NGKETLQRAD PPKTHVTHHP VSDHEATLRC WALGFYPAEI TVTWQRDGEE QTQDTELVET RPGGDGTFQK WGAVVVPSGE EQRYTCHVQH EGLPEPLTLR WEPSSQSTIP IVGIVAGLAV LAVVVTGAVV AAVMWRKKSS GGKGGGYSQA ASSDSAQGSD VSLTA // ID A0A0D9R807_CHLSB Unreviewed; 314 AA. AC A0A0D9R807; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 17. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000004746}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004746, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004746, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004746} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC241846; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000006543; ENSCSAP00000004746; ENSCSAG00000008496. DR GeneTree; ENSGT00740000114936; -. DR OMA; CVPCCKK; -. DR Proteomes; UP000029965; Chromosome 17. DR ExpressionAtlas; A0A0D9R807; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 291 310 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 188 277 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 314 AA; 35737 MW; 569D4DC5BA00B585 CRC64; SSSPELHSLR YNVTVLSRDG SVQSGFLAEG HLDGQPFLLY DRQKRRARPQ GQWAEDVLGA KTWDTETGDL TENGKDLRMT LAHIKGQKGG LHSLQEIKVC EIHEDNSTRG LRHFYYDGEL FLSQNLETQE WTELQSSRAQ TLALNIRNFW KEDTMKTKTH YRAMRADCLK KLQRYLESGV AVRRTAPPMV NVTHGEASEG NITVTCRASG FYPRNIALTW RQDGVSLNHD AQQWGDVLPD QNGTYQTWVA TRIRQGEEQR FSCYMEHSGN HSTHPVPSGK VLVFQSQWLD ISYVLAVAAG CCCYGIYYYL CPLL // ID A0A0D9R812_CHLSB Unreviewed; 383 AA. AC A0A0D9R812; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 17. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000004751}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004751, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004751, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004751} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC241846; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000006547; ENSCSAP00000004751; ENSCSAG00000008496. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000029965; Chromosome 17. DR ExpressionAtlas; A0A0D9R812; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 383 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002344726. FT TRANSMEM 310 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 303 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 383 AA; 42376 MW; 56C2B67973D7C871 CRC64; MGPGRVVLFL ASMFPFARPG AAAELHSLRY NVTVLSRDGS VQSGFLAEGH LDGQPFLLYD RQKRRARPQG QWAEDVLGAK TWDTETGDLT ENGKDLRMTL AHIKGQKGGL HSLQEIKVCE IHEDNSTRGL RHFYYDGELF LSQNLETQEW TELQSSRAQT LALNIRNFWK EDTMKTKTHY RAMRADCLKK LQRYLESGVA VRRTAPPMVN VTHGEASEGN ITVTCRASGF YPRNIALTWR QDGVSLNHDA QQWGDVLPDQ NGTYQTWVAT RIRQGEEQRF SCYMEHSGNH STHPVPSGEP GVTLERVRPA VAAAAAAAAA AIFVIILYVL CCKKKTSAAE GPELVSLQTL DQHPVGTGDH RDATQLGFQP LMSAPGSTGS TEG // ID A0A0D9RJ51_CHLSB Unreviewed; 337 AA. AC A0A0D9RJ51; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 20. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSCSAP00000008640}; GN Name=MR1 {ECO:0000313|Ensembl:ENSCSAP00000008640}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000008640, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000008640, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000008640} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AQIB01113028; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000010547; ENSCSAP00000008640; ENSCSAG00000012455. DR GeneTree; ENSGT00740000114936; -. DR OMA; GYVDSHP; -. DR Proteomes; UP000029965; Chromosome 25. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 337 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002345480. FT TRANSMEM 296 319 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 337 AA; 38986 MW; 2AB5A30C99F4CD60 CRC64; MVFLLPLIVV VMVKHSDSRT HSLRYFRLGI SDPGHGVPEF ISVGYVDSQP ITTYDSVTRQ KEPRAPWMAE NLAPDHWERY TQLLRGWQQM FKVELKRLQR HYNHSGSHTY QRMIGCELLE DGSTTGFLQY AYDGQDFLIF NKDSLSWLAV DNVAHTVKRA WEANQHELRY HKNWLEKECI AWLKRFLEYG NDTLQRTEPP LVRVNRKETF PGVTTLFCKA HGFYPPEIYV TWMKNGEEIV QEMDYGDILP SGDGTYQTWA SVELDPKSSN LYSCHVEHCG VHMVLQVPQE SETIPLVMKA VSGSIILVIV LAGVGVLVWR RRPREQNGAM YLPTPDR // ID A0A0D9RPP3_CHLSB Unreviewed; 215 AA. AC A0A0D9RPP3; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 16. DE SubName: Full=UL16 binding protein 3 {ECO:0000313|Ensembl:ENSCSAP00000010582}; GN Name=ULBP3 {ECO:0000313|Ensembl:ENSCSAP00000010582}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000010582, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000010582, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000010582} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AQIB01071641; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01071642; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01071643; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01071644; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01071645; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01071646; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01071647; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01071648; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01071649; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01071650; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000012549; ENSCSAP00000010582; ENSCSAG00000014456. DR GeneTree; ENSGT00390000003472; -. DR OMA; WGKQLEM; -. DR Proteomes; UP000029965; Chromosome 13. DR GO; GO:0046658; C:anchored component of plasma membrane; IEA:Ensembl. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IEA:Ensembl. DR GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}. FT DOMAIN 32 190 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 77 97 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 215 AA; 24806 MW; 21D260927638BE96 CRC64; MRRSRRNRVL ARAAPGVEDA HSLWYNFNIT RGQQWCEVQG QADQKNFLSY DCGSDKVLSM GHLEEQLDVT DAWGKQLEML KEAGRRLRME LADTELEDFT PSGPLTLQAR MSCECEVNGP IRGSWQFSFN GQKFLLFDSN NRKWTVVQAG ARRMKEKWED SKLTMFFQKV SMGDCKTWLR DFLMHRKKRL ELTAPPTMAP GTSQTKAMAT SLSPW // ID A0A0D9RXE7_CHLSB Unreviewed; 264 AA. AC A0A0D9RXE7; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 16. DE SubName: Full=Retinoic acid early transcript 1E {ECO:0000313|Ensembl:ENSCSAP00000013286}; GN Name=RAET1E {ECO:0000313|Ensembl:ENSCSAP00000013286}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000013286, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000013286, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000013286} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AQIB01120791; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120792; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120793; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120794; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000015342; ENSCSAP00000013286; ENSCSAG00000017250. DR GeneTree; ENSGT00390000003472; -. DR OMA; WQFAING; -. DR Proteomes; UP000029965; Chromosome 13. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IEA:Ensembl. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 32 {ECO:0000256|SAM:SignalP}. FT CHAIN 33 264 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002346245. FT TRANSMEM 226 247 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 30 198 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 264 AA; 30065 MW; 2E627AFCDA1FE689 CRC64; VPRMPLTCSP VSLLSLLLLL LTALEIMVGA HSLCFNFTIK SWSRPGQPWC EAQVFMNKNL FLQYDSDSNM VKPLGLLGKK VNATSTWGEL TQTLGEVSRD LRMLLLDIKP QIKTSGPSTL QVEMFCQREA ERCTGASWQF AINGEKCLFF DAMNMTWTVI NHEASKIKAT WKKDRGLEKY FRKLSVGDCD HWLREFSEQW EAMPEPTVSP VNVSDIHGSS SSLPDIWIIL GAFILFVLMG IFLIIYIRWR KGEWQAGLWP LKVS // ID A0A0D9RXE9_CHLSB Unreviewed; 334 AA. AC A0A0D9RXE9; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 20-JUN-2018, entry version 14. DE SubName: Full=Retinoic acid early transcript 1G {ECO:0000313|Ensembl:ENSCSAP00000013288}; GN Name=RAET1G {ECO:0000313|Ensembl:ENSCSAP00000013288}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000013288, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000013288, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000013288} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AQIB01120808; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120809; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120810; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120811; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120812; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120813; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120814; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120815; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120816; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120817; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000015345; ENSCSAP00000013288; ENSCSAG00000017253. DR GeneTree; ENSGT00390000003472; -. DR OMA; QIAKRPL; -. DR Proteomes; UP000029965; Chromosome 13. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IEA:Ensembl. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:0002729; P:positive regulation of natural killer cell cytokine production; IEA:Ensembl. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 334 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002346384. FT DOMAIN 30 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 334 AA; 37030 MW; ACA7D830ED021FA2 CRC64; MAAAASPAFL LRLLLLFLLS VWCRTGRADP HSLCYDITII PKFRPGPQWC AVQGQVDKKT FLHYDCGNKT VTPVSTLGKK LNVTKAWKAQ NPVLREVVDT LTQQLLDIEL ENYTPREPLT LQARMSCEQK AEGHSSGSWQ IRFDGQIFLL FDSENRMWTT VHPGARKMKE KWENDKDVTM SFHYISMGDC TRWLGDFLTG VDRTLEPSAG APPTMSSGAA QLRATATTLI LCCLLIMCLL MCSRHSPTHS HGHHPQSLEP PPHPPLLHPT WLQKRVLWSD SYQIGKGPLS GGHVTCVTLP IIGDDSHSLP CPLALYTINH GAARHSGPLP VSAS // ID A0A0D9RXF3_CHLSB Unreviewed; 246 AA. AC A0A0D9RXF3; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 13. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000013292}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000013292, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000013292, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000013292} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AQIB01120840; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120841; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120842; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_008004854.1; XM_008006663.1. DR RefSeq; XP_008004855.1; XM_008006664.1. DR Ensembl; ENSCSAT00000015349; ENSCSAP00000013292; ENSCSAG00000017254. DR GeneID; 103240144; -. DR KEGG; csab:103240144; -. DR GeneTree; ENSGT00390000003472; -. DR KO; K07986; -. DR OMA; YEITIIP; -. DR Proteomes; UP000029965; Chromosome 13. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 246 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002345865. FT TRANSMEM 224 244 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 30 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 246 AA; 27491 MW; 00F45B3191EF1AEC CRC64; MAAAATTKIL LCLLLLLLPS LWSRAGRTDP HSLCYEITII PKFRPGPQWC AVQGQVDKKT FLRYDCGNKT VTPISPLGKK LSVTKAWKAQ NPVLREVVDM LTEQLLDIQL ENYTPRDPLT LQAWVSCEQK AEGHSSGSWQ FGFDGQVFLL FDSENRMWTT VHPGARKMKE KWENDKDVTM SFRYISMGDC TRWLGDFLMG MDSTLEPSAG ASLTMSSGTT QLRAMATALI LCCLLIILCC FILAGI // ID A0A0D9RXF4_CHLSB Unreviewed; 244 AA. AC A0A0D9RXF4; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 13. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000013293}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000013293, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000013293, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000013293} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AQIB01120853; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120854; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_008004850.1; XM_008006659.1. DR Ensembl; ENSCSAT00000015351; ENSCSAP00000013293; ENSCSAG00000017258. DR GeneID; 103240141; -. DR KEGG; csab:103240141; -. DR CTD; 80329; -. DR GeneTree; ENSGT00390000003472; -. DR KO; K07986; -. DR OMA; CKMWLEE; -. DR Proteomes; UP000029965; Chromosome 13. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 244 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002345842. FT TRANSMEM 222 242 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 44 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 244 AA; 27726 MW; 6D37F64D196D8613 CRC64; MAAAASTAFL LCLSFLHLLS GWSRAGRADT HCLCYDFIIT PKFRPEPRWC EVQGLVDERP FLHYDCVNHK AKASASLGKK VNVTKTWEKQ TETLGDVVDF LKGQLPDIQV ENLMPIEPLI LQARMSCEHE AHGHGRGSWQ FLFNGQTFLL FDSNNRKWTA LHPGAKKMKE KWEKNTEVTM FFQKISMGDC KTWLEEFLMY WEQMLDPTKP PTVAQGTTQP KAMATTLIPC SLLLILLCFI LAGS // ID A0A0D9RXF6_CHLSB Unreviewed; 244 AA. AC A0A0D9RXF6; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 12. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000013295}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000013295, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000013295, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000013295} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AQIB01120906; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120907; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120908; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120909; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120910; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120911; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120912; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120913; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120914; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120915; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000015353; ENSCSAP00000013295; ENSCSAG00000017261. DR GeneTree; ENSGT00390000003472; -. DR OMA; ISASWEF; -. DR Proteomes; UP000029965; Chromosome 13. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 244 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002346385. FT DOMAIN 44 200 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 244 AA; 27763 MW; 9DB191B52545461E CRC64; MAVVACPAFL PCFPLLLLQS GWSGSGQDDT HCLCYDFNIT LKFRPEPRWC EVQGLVDERP FLHYDCVNHK AKASASLGKK VNVTKTWEKQ TETLGDVVDF LKGQLPDVQV ENLMPVEPLI LQAQMSCEHK AHGHGGGSWQ FLFNGQTFLL FDSNNRKWAV LYPGAKKMKD KWEKNTEVTV FFHKISMGDC KTWLEEFLIY WEKMLDPTKP HSWAPGTTQP KTMATTLSPW SLLLIILCFI LPGI // ID A0A0D9RXF7_CHLSB Unreviewed; 246 AA. AC A0A0D9RXF7; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 11. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000013296}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000013296, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000013296, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000013296} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AQIB01120944; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120945; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120946; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01120947; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000015354; ENSCSAP00000013296; ENSCSAG00000017264. DR GeneTree; ENSGT00390000003472; -. DR OMA; NISMGDC; -. DR Proteomes; UP000029965; Chromosome 13. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 246 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002346036. FT TRANSMEM 224 244 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 30 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 246 AA; 27564 MW; 5A5527AB265620CC CRC64; MAAAAATKIL LCLQLLLLLP RWSQTGRDDL HSLCYDITII PKFRPGPQWC AVQGQADKKT FLHYDCGNKT VTPVSPLGKK LNVTKAWKTQ NPVLRQVVDM LTEQLLDIQL ENYTPKEPLT LQARMSCEQK AEGHSSGSWQ FSFDGQIFLL FDSENRMWTT VHPGARKMKE KWENDKDVTM SFRYISMGDC TRWLGDFLTG MDSTLEPSAG APLTMSSGTT QLRATATTLI LCCLLIILPC FILAGI // ID A0A0D9RZ11_CHLSB Unreviewed; 298 AA. AC A0A0D9RZ11; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 23-MAY-2018, entry version 22. DE SubName: Full=Alpha-2-glycoprotein 1, zinc-binding {ECO:0000313|Ensembl:ENSCSAP00000013850}; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSCSAP00000013850}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000013850, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000013850, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000013850} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AQIB01149797; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01149798; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01149799; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01149800; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_008016796.1; XM_008018605.1. DR Ensembl; ENSCSAT00000015924; ENSCSAP00000013850; ENSCSAG00000017828. DR GeneID; 103246761; -. DR KEGG; csab:103246761; -. DR CTD; 563; -. DR GeneTree; ENSGT00740000114936; -. DR OMA; TYQSWVV; -. DR Proteomes; UP000029965; Chromosome 28. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 298 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002345964. FT DOMAIN 207 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 298 AA; 34336 MW; 94304970E8E93E4C CRC64; MVRMVPVLLS LLLLLDPAVP QETQDGHYSL TYIYTGLSKL VEDIPQFQAL GSLNDLQFFR YNSKDRKSQP VGLWRQVEGM EDWKQDSQLQ KAREDIFMET LNDIVEYYND SNGSHNLHGR FGCEIENNRS SGSFWKYYYD GKDYIEFNKE IPAWVALDPA AQNTKQKWEA EPVYVQRAKA YLEEECPATL RKYLKYSKNI LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT RDGKVQEPEL RGEVLHNENG TYQSWVVVAV PPQDTAPYSC HVQHSSLAQP LVVPGEAR // ID A0A0D9S0C0_CHLSB Unreviewed; 408 AA. AC A0A0D9S0C0; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 23-MAY-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000014309}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000014309, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000014309} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR RefSeq; XP_008017368.1; XM_008019177.1. DR Ensembl; ENSCSAT00000016395; ENSCSAP00000014309; ENSCSAG00000018298. DR GeneID; 103247140; -. DR GeneTree; ENSGT00760000118960; -. DR OMA; GYCQEAY; -. DR Proteomes; UP000029965; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 408 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002346408. FT TRANSMEM 354 375 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 252 340 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 408 AA; 45096 MW; 9B7EFAD04ADD250A CRC64; MAVMAPRTLL LVLSGVLALT QTRAGECGAG REMASAGRSE GTAGGGAGPG EPRGEEGRAG LSLSSPPGSH SMRYFHTSVS RPGRGEPRFF AVGYVDDTQF VRFDSNAASQ RMEPRAPWVE QEGPEYWDRE TRIMKGETQR APMDLRILRG YYNQSEAGSH TYQRMYGCDL GPDGRLLRGY EQLAYDGRDY IALNEDLRSW TAADLAAQNT QRKWEAEGWA EQVRAYLEGR CVEWLRRYLE NGKETLQRAD PPKTHVTHHP VSDYEATLRC WALGFYPAEI TLTWQLDGED QTQDTELVET RPTGDGTFQK WAAVVVPSGK EQRYTCHVQH EGLPEPLTLR WEPSSQSTIP IVDIIVGLVL LGAVVTGTVV TAVMWRRKSS DRKGGSYSQA ASGDSAQGSD VSLTACKV // ID A0A0D9S0C1_CHLSB Unreviewed; 362 AA. AC A0A0D9S0C1; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 23-MAY-2018, entry version 21. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000014310}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000014310, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000014310} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSCSAT00000016398; ENSCSAP00000014310; ENSCSAG00000018299. DR GeneTree; ENSGT00760000118960; -. DR OMA; VPGYYNQ; -. DR Proteomes; UP000029965; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002346533. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40440 MW; 238605118F68AE79 CRC64; MRVVAPRTLL LLLSGTLALT ETWAGSHSLR YFHTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAESPRME PRAPWVEQEG PEFWEEQTRN AQGHAQNHRV CLRTVPGYYN QSEAGSHTFQ RMYGCDLGPD GRLLRGYNQY AYDGKDYIAL NEDLRSWTSA DVAAQNTQRK WEATRYAEQF RAYLEETCVE SLRRHLENGK EILQRADPPK THVTHHPVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWGA VVVPSGEEQR YTCHVQHKGL PEPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVTGAVVAAV MWRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID A0A0D9S3V2_CHLSB Unreviewed; 345 AA. AC A0A0D9S3V2; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 19. DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSCSAP00000015541}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSCSAP00000015541}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000015541, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000015541, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000015541} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AQIB01135602; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01135603; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01135604; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIB01135605; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCSAT00000000520; ENSCSAP00000015541; ENSCSAG00000002513. DR GeneTree; ENSGT00740000114936; -. DR OMA; PWISLRG; -. DR Proteomes; UP000029965; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019864; F:IgG binding; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 278 301 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 182 269 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 345 AA; 37657 MW; C29AD5FEF5AF68C4 CRC64; SLSAESHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLS YDSLRGQAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE AFKALGGKGP YTLQGLLGCE LSPDNTSVPT AKFALNGEEF MNFDHKQGTW GGDWPEALAI SQRWQQQDKA ANKELTFLLF SCPHRLREHL ERGRGNLEWK EPPSMRLKAR PGNPGFSVLT CSAFSFYPPE LQLRFLRNGL AAGTGQGDFG PNSDGSFHAS SSLTVKSGDE HHYCCIVQHA GLAQPLRVEL ETPAKSSVLV VGIVIGVLLL TAAAVGGALL WRRMRSGLPA PWISLRGDDT GSLLPTPGEA QDADSKDINV IPATA // ID A0A0F8ALW3_LARCR Unreviewed; 490 AA. AC A0A0F8ALW3; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 25-OCT-2017, entry version 14. DE SubName: Full=Class I histocompatibility antigen, Gogo-B*0103 alpha chain {ECO:0000313|EMBL:KKF22831.1}; GN ORFNames=EH28_04240 {ECO:0000313|EMBL:KKF22831.1}; OS Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Sciaenidae; Larimichthys. OX NCBI_TaxID=215358 {ECO:0000313|EMBL:KKF22831.1, ECO:0000313|Proteomes:UP000054355}; RN [1] {ECO:0000313|EMBL:KKF22831.1, ECO:0000313|Proteomes:UP000054355} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SSNF {ECO:0000313|EMBL:KKF22831.1}; RC TISSUE=Blood {ECO:0000313|EMBL:KKF22831.1}; RX PubMed=25835551; RA Ao J., Mu Y., Xiang L.X., Fan D., Feng M., Zhang S., Shi Q., Zhu L.Y., RA Li T., Ding Y., Nie L., Li Q., Dong W.R., Jiang L., Sun B., Zhang X., RA Li M., Zhang H.Q., Xie S., Zhu Y., Jiang X., Wang X., Mu P., Chen W., RA Yue Z., Wang Z., Wang J., Shao J.Z., Chen X.; RT "Genome Sequencing of the Perciform Fish Larimichthys crocea Provides RT Insights into Molecular and Genetic Mechanisms of Stress Adaptation."; RL PLoS Genet. 11:E1005118-E1005118(2015). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KQ041794; KKF22831.1; -; Genomic_DNA. DR Proteomes; UP000054355; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054355}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000054355}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 490 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002526885. FT TRANSMEM 362 384 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 256 345 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 490 AA; 55913 MW; 5E186DC4F07A3259 CRC64; MDRPQTWIFL FLPVLGLNLD PAVSEKHSLT YIYTAFSKPV NLPGIHDFTA MGLLDDRMID YYDSDVQKKV PKEDWMKTRM DEDYWKKGTQ SRQSKHQWFK VNMEILMKRM RQNESDVHIL QWMHGCKGEE NPDGSLRFVQ GKDMYNYDGQ DFLSFDDANA VWWMHGCKGE EHPDGSLRFV QGKDMYNYDG QDFLSFDDAN AVWVAPVDAA VETKRKWDDV RVLKEYTKGY LENECIEWLT KFVTYEKAQL RKAKPPKVHL FTKNSRVQTN VILTCLATGF YPKDIELYIK RDGRTLTRQD GVQTFGVRPN EDDTYQRRDY VEILKSDKSK YTCHVIHRAS LVDIEAEWDR RLPDIEGNGS SIIWVVGGIV AVVVLLAVVL GVLFKKGIIG SSRSLKCSSC SSGSSQGSLN SGSSGRSDAN GEKVHLNPDT ESKKSDSSSD SGISRSERNV PAARERTALS DVGTSQRKNE ARSRTRSDEL GPNTLDEKFR // ID A0A0F8AX75_LARCR Unreviewed; 308 AA. AC A0A0F8AX75; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:KKF15518.1}; GN ORFNames=EH28_00490 {ECO:0000313|EMBL:KKF15518.1}; OS Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Sciaenidae; Larimichthys. OX NCBI_TaxID=215358 {ECO:0000313|EMBL:KKF15518.1, ECO:0000313|Proteomes:UP000054355}; RN [1] {ECO:0000313|EMBL:KKF15518.1, ECO:0000313|Proteomes:UP000054355} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SSNF {ECO:0000313|EMBL:KKF15518.1}; RC TISSUE=Blood {ECO:0000313|EMBL:KKF15518.1}; RX PubMed=25835551; RA Ao J., Mu Y., Xiang L.X., Fan D., Feng M., Zhang S., Shi Q., Zhu L.Y., RA Li T., Ding Y., Nie L., Li Q., Dong W.R., Jiang L., Sun B., Zhang X., RA Li M., Zhang H.Q., Xie S., Zhu Y., Jiang X., Wang X., Mu P., Chen W., RA Yue Z., Wang Z., Wang J., Shao J.Z., Chen X.; RT "Genome Sequencing of the Perciform Fish Larimichthys crocea Provides RT Insights into Molecular and Genetic Mechanisms of Stress Adaptation."; RL PLoS Genet. 11:E1005118-E1005118(2015). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KQ042349; KKF15518.1; -; Genomic_DNA. DR Proteomes; UP000054355; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000054355}; KW Reference proteome {ECO:0000313|Proteomes:UP000054355}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 308 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002527170. FT DOMAIN 202 276 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 308 AA; 35595 MW; 625D6A29226F4DD1 CRC64; MKKIFLLLLF CQVSSSVKHS LKYFTTVSSG VTNFPEFVAT VMIDDILLGY CDSNTKKLEL KYDWMKKLAE EDPQQLDYYN IQCFQREPNF FKATISHLKQ RFNQSGGVHI LQRVSGCEWD DETGEVHGFN QFGYDGEDFI SFDLKTSTWI TPKPQVSIIK QRWDADKAGI EFIVNYHTQI YPEWLKKYVV YGSSSVVRTE LPSVSLLQKT PSSPVTCHAT GFYPDRAMMF WRKDGEEFHE DVDHGEILPN HDGTFQMSVD LNLSSVTPED WRRYDCVFHL SGVEDDIVTR LDKAEIRTNW GKTGIRGC // ID A0A0F8B3E2_LARCR Unreviewed; 378 AA. AC A0A0F8B3E2; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=RLA class I histocompatibility antigen, alpha chain 19-1 {ECO:0000313|EMBL:KKF22829.1}; GN ORFNames=EH28_04238 {ECO:0000313|EMBL:KKF22829.1}; OS Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Sciaenidae; Larimichthys. OX NCBI_TaxID=215358 {ECO:0000313|EMBL:KKF22829.1, ECO:0000313|Proteomes:UP000054355}; RN [1] {ECO:0000313|EMBL:KKF22829.1, ECO:0000313|Proteomes:UP000054355} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SSNF {ECO:0000313|EMBL:KKF22829.1}; RC TISSUE=Blood {ECO:0000313|EMBL:KKF22829.1}; RX PubMed=25835551; RA Ao J., Mu Y., Xiang L.X., Fan D., Feng M., Zhang S., Shi Q., Zhu L.Y., RA Li T., Ding Y., Nie L., Li Q., Dong W.R., Jiang L., Sun B., Zhang X., RA Li M., Zhang H.Q., Xie S., Zhu Y., Jiang X., Wang X., Mu P., Chen W., RA Yue Z., Wang Z., Wang J., Shao J.Z., Chen X.; RT "Genome Sequencing of the Perciform Fish Larimichthys crocea Provides RT Insights into Molecular and Genetic Mechanisms of Stress Adaptation."; RL PLoS Genet. 11:E1005118-E1005118(2015). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KQ041794; KKF22829.1; -; Genomic_DNA. DR Proteomes; UP000054355; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000054355}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000054355}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 378 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002527526. FT TRANSMEM 312 337 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 378 AA; 43733 MW; 448109C16114605A CRC64; MYLSVAALLM ASLCRHAVEI HSLTYIYTAF SKPVNLPGIH DFTAMGLLDD RMIDYYDSDV QKKVPKEDWM KTRMDEDYWK KGTQSRQSKH QWFKVNMEIL MKRMRQNESD VHILQWMHGC KGEERPDGFL RFVQGKDMYN YDGQDFLSFD DANAVWVAPV DAAVETKRKW DEVRVLKEYT KGYLENECIE WLTKFITYEK EQLRTAKPPE VHLFTKNSRV QTNVILTCLV SGFYPKDIEL YIKRDGRTLT RQDGVETFGI RPNEDDTYQR RDYVEILKSD KSKYTCQVIH RASGLNVESS WDRRLPDSPK GIGLIIGTVE GALGVLGVLA VVPGVLFKKG KLDSKKSDSS SDSGISHGSA RGQYTQRFVD MDRYRYTS // ID A0A0F8BNJ7_LARCR Unreviewed; 2081 AA. AC A0A0F8BNJ7; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 28-FEB-2018, entry version 20. DE SubName: Full=ATPase family AAA domain-containing protein 2 {ECO:0000313|EMBL:KKF14010.1}; GN ORFNames=EH28_04970 {ECO:0000313|EMBL:KKF14010.1}; OS Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Sciaenidae; Larimichthys. OX NCBI_TaxID=215358 {ECO:0000313|EMBL:KKF14010.1, ECO:0000313|Proteomes:UP000054355}; RN [1] {ECO:0000313|EMBL:KKF14010.1, ECO:0000313|Proteomes:UP000054355} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SSNF {ECO:0000313|EMBL:KKF14010.1}; RC TISSUE=Blood {ECO:0000313|EMBL:KKF14010.1}; RX PubMed=25835551; RA Ao J., Mu Y., Xiang L.X., Fan D., Feng M., Zhang S., Shi Q., Zhu L.Y., RA Li T., Ding Y., Nie L., Li Q., Dong W.R., Jiang L., Sun B., Zhang X., RA Li M., Zhang H.Q., Xie S., Zhu Y., Jiang X., Wang X., Mu P., Chen W., RA Yue Z., Wang Z., Wang J., Shao J.Z., Chen X.; RT "Genome Sequencing of the Perciform Fish Larimichthys crocea Provides RT Insights into Molecular and Genetic Mechanisms of Stress Adaptation."; RL PLoS Genet. 11:E1005118-E1005118(2015). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KQ042510; KKF14010.1; -; Genomic_DNA. DR Proteomes; UP000054355; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0016887; F:ATPase activity; IEA:InterPro. DR GO; GO:0006325; P:chromatin organization; IEA:InterPro. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro. DR Gene3D; 1.20.920.10; -; 1. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR031252; ANCCA. DR InterPro; IPR003959; ATPase_AAA_core. DR InterPro; IPR003960; ATPase_AAA_CS. DR InterPro; IPR001487; Bromodomain. DR InterPro; IPR036427; Bromodomain-like_sf. DR InterPro; IPR018359; Bromodomain_CS. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR23069:SF4; PTHR23069:SF4; 2. DR Pfam; PF00004; AAA; 1. DR Pfam; PF00439; Bromodomain; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF13516; LRR_6; 4. DR Pfam; PF00129; MHC_I; 2. DR PRINTS; PR00503; BROMODOMAIN. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00382; AAA; 1. DR SMART; SM00297; BROMO; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF47370; SSF47370; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52540; SSF52540; 2. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS00674; AAA; 1. DR PROSITE; PS00633; BROMODOMAIN_1; 1. DR PROSITE; PS50014; BROMODOMAIN_2; 1. DR PROSITE; PS00290; IG_MHC; 1. DR PROSITE; PS51450; LRR; 5. PE 3: Inferred from homology; KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035, KW ECO:0000256|SAAS:SAAS00979529}; KW Complete proteome {ECO:0000313|Proteomes:UP000054355}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000054355}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 572 592 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1768 1830 Bromo. {ECO:0000259|PROSITE:PS50014}. SQ SEQUENCE 2081 AA; 234360 MW; 9BC6F232DFA74BEB CRC64; MEMNDDSVRQ EIQEFLKSEN RSKMKLSAIH CSALAYMLQM SEKVLDELDL QKFNTSEEGR QRLIPAVRNY RKAKFSGCGL SETHCEVVAS ALKSNPSHLT ELDLSKNMLQ DSGVKTLSTG LESTNCRLRR CSLSEISCAS LASAMKSNPS HLRVLDLSDN ELQDSVKLLC DFLQSPHCRL KTLRLLSCRL SEISCGSLAS ALKSNPSHLR DLDLSNNKLQ DLGVKLLCDF LESPHHKLET LGLRCCGLTK DSCDSLYSAL KSNPSKLRDL DLSNNELQDS GVQLRDLVQN LRINITPGGH IEEIHSLTYI YTAFSKPVNL PGIHDFTAMG LLDDRMIDYY DSDVQKKVPK EDWMKTRMDE DYWKKGTQSR QSKHQWFKVN MEILMKRMRQ NESDVHILQW MHGCKGEENP DGSLRFVQGK DMYNYDGQDF LSFDDANAVW VAPVDAAVET KRKWDDVRVL KEYTKGYLEN ECIEWLTKFI TYEKEQLRKA RFYPKDIQLV MKRGDHTLTR QDGVDTFGVR PNEDDTYQRR DYVEILKSDK SNYTCHVIHR ASGLNVEKEW VHRFIHGGSG PVVGRLVGVI LLVLFLIVAV VLCVLCKKCK IEIHSLTYIY TAFSKPVNLP GIHDFTAMGL LDDRMIDYYD SDVQKKVPKE DWMKTRMDED YWKKGTQSRQ SKHQWFKVNM EILMKRMRQN ESDVHILQWM HGCKGEENPD GSLRFVQGKD MYNYDGQDFL FFDDANAVWV ALLVRAQQLQ LATRLNSQLV DTKQGFDAAD HVDHEEPARA VVRKSPRLQN AAGENILEYQ GGLEKQSWNE LSSSQQSESK PGCKHEGFDA ADHVDHEEPA RAVVRKSPRL QNAAGENILE YQGGLEKQSW NELSSSQQSE SKPGCKHETR RLPLDRDTFA PRVNVAVSPC TARSVLKKMD NMKKRRWLSN NKEGKIYSKA QRRTPVPSQS DSENDSGAHE PRIIQNATFM PTKPTSRYQA SNMFDGIGTN TARSVLKKMD NMKKRRWLSN NKEGKIYSKA QRRTPVPSQS DSENDSGGVD DEDSRQEVAT DEDSNCSTDQ NFDAKLSRAS VLYQGPSSEF LRGTFRISAS GPNTTRRGAF RPTKGVWSNQ SDEDDSDHEE QNVSDSSRRL GLRTDDRLGT RRDKMNAGAG LADIDPMAID QSVGFDSIGG LSGHISALKE MVVFPLLYPE VFDNFKIQPP RGCLFYGPPG TGKTLVARAL ANECSHGNRK VAFFMRKGAD CLSKWVGESE RQLRLLFEQA YQMRPSIIFF DEIDGLAPVR SSRQDQIHSS IVSTLLALMD GLDSRGEVVV IGATNRLDSI DPALRRPGRF DREFLFGLPD RESRKEILKI HTRQWKPPPS EDFLDELAEK CVGYCGADIR AVCTEAALCA LRRRYPQIYG TSQKLLLDVS SITVSSCDFV AAMRKMSPAS HRLAASPAKP LSPVVHPLLG AALRDILDAL QRLFPHAEQG MKRKREPDLT SGVLDDGLMS GGDEISSISA PSTTKSRNFL HFARRVRATL HRDVDQQMSG LCKLTFLLSC RSAVKHPTSY RPRMLLAGRP GAGQTSHLAP AVLHTLERFT VHSLDSAVLF GVSCTSPEET CAQVFCEAKR TSPSILYIPH IQQWWETAGA SLRASFFSLL SSIPSFSPIL LLATCSVSHQ HLDPEIQSLF REEYGEVYTI SVPTQLERTN FFEDLILNQA VEAPSSKKQP LNQALEILPV APPPPPRQLS EQERLCLEEQ EEDVLRELRL FLRNVTEHLS LDRRFKAFTK PVDIEEVPDY LLVIKKPMDL STLLTNIDEQ KYVTVGEFMS DADLIWQNAL EYNPDSDPMA RKKKRYKRKS KWSTGIIKKP KRKKLPFPPS SSSSSSSSLF SSSSVSSRGN SGSGPVENGG IDMRAVSGSA CPSSSAMSES SDGEAAAVNG HHHDLNGITV VQNGVHMNGY HRSLDLQPAD SIATGRLNLR DRARASKTPP NLKMMANGVR LSNTEKSQSN ETRANKAAME QIQLFNRGRS EVLHEGASQL VVSHSKLKDL LRRAVAKTDG AEVEPLEKLY ALLAQSIYRH RNIYNKTELI QEMQKEVDGF S // ID A0A0F8D133_LARCR Unreviewed; 384 AA. AC A0A0F8D133; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:KKF32183.1}; GN ORFNames=EH28_00289 {ECO:0000313|EMBL:KKF32183.1}; OS Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Sciaenidae; Larimichthys. OX NCBI_TaxID=215358 {ECO:0000313|EMBL:KKF32183.1, ECO:0000313|Proteomes:UP000054355}; RN [1] {ECO:0000313|EMBL:KKF32183.1, ECO:0000313|Proteomes:UP000054355} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SSNF {ECO:0000313|EMBL:KKF32183.1}; RC TISSUE=Blood {ECO:0000313|EMBL:KKF32183.1}; RX PubMed=25835551; RA Ao J., Mu Y., Xiang L.X., Fan D., Feng M., Zhang S., Shi Q., Zhu L.Y., RA Li T., Ding Y., Nie L., Li Q., Dong W.R., Jiang L., Sun B., Zhang X., RA Li M., Zhang H.Q., Xie S., Zhu Y., Jiang X., Wang X., Mu P., Chen W., RA Yue Z., Wang Z., Wang J., Shao J.Z., Chen X.; RT "Genome Sequencing of the Perciform Fish Larimichthys crocea Provides RT Insights into Molecular and Genetic Mechanisms of Stress Adaptation."; RL PLoS Genet. 11:E1005118-E1005118(2015). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KQ040967; KKF32183.1; -; Genomic_DNA. DR Proteomes; UP000054355; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 2. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000054355}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000054355}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 346 370 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 247 319 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 384 AA; 44309 MW; 35998F88EE14965A CRC64; MVYYDSKTQK VELKQDWMNK VTAGDPQYLE RSTRIFLGDQ KIFKASIDTL KNRFNQTGGV HIFQFMYGCE WDDETGKVTG FNQHGYDGED FLSLDLKTET WIAPKQQAVI TKNKWDLDKA WIAQSKNYIT QICPEWVKKY VNYGRSSLMR TGVHIYQWMF GCEWDDETGK VTGFDQYGYD GEDFISLDLK TETWIAPKQQ AVITKNRWDQ DKARIAQIKN YITQICPEWV KKYVNYGRSS LMRTELPSVS LLQKTSSSPV TCHATGFYPD RASLVWKKDG VELHENVDHG EIVPNHDGTF QMSIDLKPDA SEDWSKYDCV FQLAGVKKDI VTRLDKKAIL TNEQNLMMII IIVAVAVLAL AIAGIGFFIY KQKKGERPKP KYIV // ID A0A0G2JH50_HUMAN Unreviewed; 372 AA. AC A0A0G2JH50; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 18-JUL-2018, entry version 23. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000372813}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000372813}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000372813, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000372813, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [3] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [4] {ECO:0000313|Ensembl:ENSP00000372813} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. RN [5] {ECO:0000313|Ensembl:ENSP00000372979} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX248310; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX322539; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EPD; A0A0G2JH50; -. DR PRIDE; A0A0G2JH50; -. DR Ensembl; ENST00000383323; ENSP00000372813; ENSG00000206452. DR Ensembl; ENST00000383487; ENSP00000372979; ENSG00000206435. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A0G2JH50, KW ECO:0000213|MaxQB:A0A0G2JH50, ECO:0000213|PeptideAtlas:A0A0G2JH50}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 372 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014514154. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 372 AA; 41565 MW; DF918B04998AD251 CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVQF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV NLRKLRGYYN QSEAGSHTLQ RMYGCDLGPD GRLLRGYNQF AYDGKDYIAL NEDLRSWTAA DKAAQITQRK WEAAREAEQR RAYLEGTCVE WLRRYLENGK KTLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWGP SSQPTIPIVG IVAGLAVLAV LAVLGAVMAV VMCRRKSSGH FLPTGGKGGS CSQAASSNSA QGSDESLIAC KA // ID A0A0G2JH58_HUMAN Unreviewed; 383 AA. AC A0A0G2JH58; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 23-MAY-2018, entry version 21. DE SubName: Full=MHC class I polypeptide-related sequence B {ECO:0000313|Ensembl:ENSP00000373006}; GN Name=MICB {ECO:0000313|Ensembl:ENSP00000373006}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000373006, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000373006, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000373006} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR753820; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A0G2JH58; -. DR MaxQB; A0A0G2JH58; -. DR PeptideAtlas; A0A0G2JH58; -. DR Ensembl; ENST00000383514; ENSP00000373006; ENSG00000224378. DR HGNC; HGNC:7091; MICB. DR OrthoDB; EOG091G0ANY; -. DR PhylomeDB; A0A0G2JH58; -. DR ChiTaRS; MICB; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Proteomics identification {ECO:0000213|MaxQB:A0A0G2JH58, KW ECO:0000213|PeptideAtlas:A0A0G2JH58}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 383 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002546469. FT DOMAIN 207 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 383 AA; 42588 MW; 3E6B83A126E11831 CRC64; MGLGRVLLFL AVAFPFAPPA AAAEPHSLRY NLMVLSQDGS VQSGFLAEGH LDGQPFLRYD RQKRRAKPQG QWAEDVLGAK TWDTETEDLT ENGQDLRRTL THIKDQKGGL HSLQEIRVCE IHEDSSTRGS RHFYYDGELF LSQNLETQES TVPQSSRAQT LAMNVTNFWK EDAMKTKTHY RAMQADCLQK LQRYLKSGVA IRRTVPPMVN VICSEVSEGN ITVTCRASSF YPRNITLTWR QDGVSLSHNT QQWGDVLPDG NGTYQTWVAT RIRQGEEQRF TCYMEHSGNH GTHPVPSGKA LVLQSQRTDF PYVSAAMPCF VIIIILCVPC CKKKTSAAEG PELVSLQVLD QHPVGTGDHR DAAQLGFQPL MSATGSTGST EGT // ID A0A0G2JH66_HUMAN Unreviewed; 442 AA. AC A0A0G2JH66; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 23-MAY-2018, entry version 24. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000373123}; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000373123}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000373123, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000373123, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000373123} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSP00000387786} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL669813; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL844851; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX927250; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR753818; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000383516; ENSP00000373008; ENSG00000137403. DR Ensembl; ENST00000383627; ENSP00000373123; ENSG00000206509. DR Ensembl; ENST00000428296; ENSP00000387786; ENSG00000235220. DR Ensembl; ENST00000445657; ENSP00000414905; ENSG00000237508. DR HGNC; HGNC:4963; HLA-F. DR OrthoDB; EOG091G09OH; -. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A0G2JH66, KW ECO:0000213|PeptideAtlas:A0A0G2JH66}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 442 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014514142. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 350 370 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 390 412 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 284 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 442 AA; 50428 MW; 645BF1E7D4977268 CRC64; MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL QRADPPKAHV AHHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPQP LILRWEQSPQ PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAAYSVV SGNLMITWWS SLFLLGVLFQ GYLGCLRSHS VLGRRKVGDM WILFFLWLWT SFNTAFLALQ SLRFGFGFRR GRSFLLRSWH HLMKRVQIKI FD // ID A0A0G2JH91_HUMAN Unreviewed; 340 AA. AC A0A0G2JH91; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 23-MAY-2018, entry version 21. DE SubName: Full=MHC class I polypeptide-related sequence B {ECO:0000313|Ensembl:ENSP00000383167}; GN Name=MICB {ECO:0000313|Ensembl:ENSP00000383167}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000383167, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000383167, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000383167} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSP00000409347} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX001040; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX005439; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000400313; ENSP00000383167; ENSG00000206449. DR Ensembl; ENST00000451789; ENSP00000409347; ENSG00000227772. DR HGNC; HGNC:7091; MICB. DR ChiTaRS; MICB; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Proteomics identification {ECO:0000213|MaxQB:A0A0G2JH91, KW ECO:0000213|PeptideAtlas:A0A0G2JH91}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 340 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014514126. FT DOMAIN 164 259 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 37551 MW; 84F5300FC3512D70 CRC64; MGLGRVLLFL AVAFPFAPPA AAAEPHSLRY NLMVLSQDGS VQSGFLAEGH LDGQPFLRYD RQKRRAKPQG QWAEDVLGAK TWDTETEDLT ENGQDLRRTL THIKDQKGVP QSSRAQTLAM NVTNFWKEDA MKTKTHYRAM QADCLQKLQR YLKSGVAIRR TVPPMVNVTC SEVSEGNITV TCRASSFYPR NITLTWRQDG VSLSHNTQQW GDVLPDGNGT YQTWVATRIR QGEEQRFTCY MEHSGNHGTH PVPSGKALVL QSQRTDFPYV SAAMPCFVII IILCVPCCKK KTSAAEGPEL VSLQVLDQHP VGTGDHRDAA QLGFQPLMSA TGSTGSTEGA // ID A0A0G2JHB5_HUMAN Unreviewed; 340 AA. AC A0A0G2JHB5; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 18-JUL-2018, entry version 23. DE SubName: Full=MHC class I polypeptide-related sequence B {ECO:0000313|Ensembl:ENSP00000387401}; GN Name=MICB {ECO:0000313|Ensembl:ENSP00000387401}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000387401, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000387401, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000387401} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR788288; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001276090.1; NM_001289161.1. DR UniGene; Hs.731446; -. DR ProteinModelPortal; A0A0G2JHB5; -. DR PeptideAtlas; A0A0G2JHB5; -. DR PRIDE; A0A0G2JHB5; -. DR Ensembl; ENST00000442104; ENSP00000387401; ENSG00000231179. DR GeneID; 4277; -. DR CTD; 4277; -. DR HGNC; HGNC:7091; MICB. DR PhylomeDB; A0A0G2JHB5; -. DR ChiTaRS; MICB; human. DR GenomeRNAi; 4277; -. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Proteomics identification {ECO:0000213|MaxQB:A0A0G2JHB5, KW ECO:0000213|PeptideAtlas:A0A0G2JHB5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 340 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002545976. FT DOMAIN 164 259 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 37580 MW; 988732A5C354E210 CRC64; MGLGRVLLFL AVAFPFAPPA AAAEPHSLRY NLMVLSQDGS VQSGFLAEGH LDGQPFLRYD RQKRRAKPQG QWAENVLGAK TWDTETEDLT ENGQDLRRTL THIKDQKGVP QSSRAQTLAM NVTNFWKEDA MKTKTHYRAM QADCLQKLQR YLKSGVAIRR TVPPMVNVTC SEVSEGNITV TCRASSFYPR NITLTWRQDG VSLSHNTQQW GDVLPDGNGT YQTWVATRIR QGEEQRFTCY MEHSGNHGTH PVPSGKALVL QSQRTDFPYV SAAMPCFVII IILCVPCCKK KTSAAEGPEL VSLQVLDQHP VGTGDHRDAA QLGFQPLMSA TGSTGSTEGT // ID A0A0G2JI36_HUMAN Unreviewed; 299 AA. AC A0A0G2JI36; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 18-JUL-2018, entry version 22. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000394889}; GN Name=HLA-A {ECO:0000313|Ensembl:ENSP00000394889}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000394889, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000394889, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [4] {ECO:0000313|Ensembl:ENSP00000394889} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL645935; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL671561; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759913; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759943; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759960; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CT009496; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PRIDE; A0A0G2JI36; -. DR Ensembl; ENST00000416096; ENSP00000394889; ENSG00000229215. DR Ensembl; ENST00000442939; ENSP00000397962; ENSG00000224320. DR HGNC; HGNC:4931; HLA-A. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Proteomics identification {ECO:0000213|EPD:A0A0G2JI36, KW ECO:0000213|MaxQB:A0A0G2JI36, ECO:0000213|PeptideAtlas:A0A0G2JI36}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 299 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014514108. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 299 AA; 34216 MW; B65892845D3A4B24 CRC64; MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQKME PRAPWIEQEG PEYWDQETRN MKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAVHAAEQR RVYLEGRCVD GLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWV // ID A0A0G2JIF0_HUMAN Unreviewed; 368 AA. AC A0A0G2JIF0; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 23-MAY-2018, entry version 21. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000398169}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000398169}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000398169, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000398169, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000398169} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. RN [4] {ECO:0000313|Ensembl:ENSP00000403541} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX248310; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX322539; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000434884; ENSP00000398169; ENSG00000206452. DR Ensembl; ENST00000458668; ENSP00000403541; ENSG00000206435. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:A0A0G2JIF0, KW ECO:0000213|MaxQB:A0A0G2JIF0, ECO:0000213|PeptideAtlas:A0A0G2JIF0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 368 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014514110. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 41468 MW; 2D1BC1715258AD08 CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVQF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV NLRKLRGYYN QSEAGSHTLQ RMYGCDLGPD GRLLRGYNQF AYDGKDYIAL NEDLRSWTAA DKAAQITQRK WEAAREAEQR RAYLEGTCVE WLRRYLENGK KTLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWGP SSQPTIPIVG IVAGLAVLAV LAVLGAVMAV VMCRRKSSAA CVGLRCRISS HLSFVTSRAS GISFCKGI // ID A0A0G2JIF2_HUMAN Unreviewed; 371 AA. AC A0A0G2JIF2; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 18-JUL-2018, entry version 26. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000398188}; GN Name=HLA-A {ECO:0000313|Ensembl:ENSP00000398188}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000398188, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000398188, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] {ECO:0000313|Ensembl:ENSP00000398188} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL645935; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL671561; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759913; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759943; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759960; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CT009496; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EPD; A0A0G2JIF2; -. DR PRIDE; A0A0G2JIF2; -. DR Ensembl; ENST00000417978; ENSP00000388724; ENSG00000224320. DR Ensembl; ENST00000444289; ENSP00000398188; ENSG00000229215. DR HGNC; HGNC:4931; HLA-A. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A0G2JIF2, KW ECO:0000213|MaxQB:A0A0G2JIF2, ECO:0000213|PeptideAtlas:A0A0G2JIF2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 371 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014514128. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 371 AA; 41373 MW; 29E10AF30B61146D CRC64; MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQKME PRAPWIEQEG PEYWDQETRN MKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAVHAAEQR RVYLEGRCVD GLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSGGE GVKDRKGGSY TQAASSDSAQ GSDVSLTACK V // ID A0A0G2JK11_HUMAN Unreviewed; 289 AA. AC A0A0G2JK11; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 23-MAY-2018, entry version 20. DE SubName: Full=MHC class I polypeptide-related sequence A {ECO:0000313|Ensembl:ENSP00000412992}; GN Name=MICA {ECO:0000313|Ensembl:ENSP00000412992}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000412992, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000412992, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000412992} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL669854; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX005439; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX119958; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000414473; ENSP00000395954; ENSG00000231225. DR Ensembl; ENST00000446505; ENSP00000412992; ENSG00000233051. DR HGNC; HGNC:7090; MICA. DR ChiTaRS; MICA; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A0G2JK11}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 289 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014514132. FT DOMAIN 164 253 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 289 AA; 32709 MW; 14349AEA2050E7D7 CRC64; MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLAEVH LDGQPFLRYD RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL AHIKDQKEVP QSSRAQTLAM NVRNFLKEDA MKTKTHYHAM HADCLQELRR YLESGVVLRR TVPPMVNVTR SEASEGNITV TCRASSFYPR NIILTWRQDG VSLSHDTQQW GDVLPDGNGT YQTWVATRIC RGEEQRFTCY MEHSGNHSTH PVPSGKVLVL QSHWQTFHVS AVAAGCCYFC YYYFLCPLL // ID A0A0G2JKJ1_HUMAN Unreviewed; 131 AA. AC A0A0G2JKJ1; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 18-JUL-2018, entry version 20. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000431141}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000431141}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000431141, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000431141, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000431141} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX248310; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX322539; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PRIDE; A0A0G2JKJ1; -. DR Ensembl; ENST00000469544; ENSP00000436915; ENSG00000206452. DR Ensembl; ENST00000485321; ENSP00000431141; ENSG00000206435. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A0G2JKJ1, KW ECO:0000213|MaxQB:A0A0G2JKJ1, ECO:0000213|PeptideAtlas:A0A0G2JKJ1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 131 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014514163. FT DOMAIN 26 115 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 131 AA; 15163 MW; FB22FF40E6559D32 CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVQF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV NLRKLRGYYN QSEAEDVWLR PGARRAPPPR V // ID A0A0G2JL56_HUMAN Unreviewed; 394 AA. AC A0A0G2JL56; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 18-JUL-2018, entry version 25. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000449453}; GN Name=HLA-A {ECO:0000313|Ensembl:ENSP00000449453}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000449453, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000449453, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] {ECO:0000313|Ensembl:ENSP00000449453} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL645935; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL671561; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759913; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759943; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759960; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CT009496; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PRIDE; A0A0G2JL56; -. DR Ensembl; ENST00000551120; ENSP00000449453; ENSG00000229215. DR Ensembl; ENST00000552498; ENSP00000448516; ENSG00000224320. DR HGNC; HGNC:4931; HLA-A. DR OrthoDB; EOG091G09OH; -. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A0G2JL56, KW ECO:0000213|MaxQB:A0A0G2JL56, ECO:0000213|PeptideAtlas:A0A0G2JL56}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 394 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014514184. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 394 AA; 44257 MW; E031E032C0D2FFD8 CRC64; MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQKME PRAPWIEQEG PEYWDQETRN MKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAVHAAEQR RVYLEGRCVD GLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL TACKGESLEG LMCVGCWVEQ WTQLCYGVSL RWMY // ID A0A0G2JNV5_HUMAN Unreviewed; 254 AA. AC A0A0G2JNV5; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 23-MAY-2018, entry version 15. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000482177}; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000482177}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000482177, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000482177, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000482177} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759790; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A0G2JNV5; -. DR SMR; A0A0G2JNV5; -. DR PeptideAtlas; A0A0G2JNV5; -. DR Ensembl; ENST00000613731; ENSP00000482177; ENSG00000234487. DR HGNC; HGNC:4963; HLA-F. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A0G2JNV5, KW ECO:0000213|PeptideAtlas:A0A0G2JNV5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 254 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002546628. FT TRANSMEM 211 237 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 22 200 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 186 206 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 254 AA; 28533 MW; 6C1496FE8F82DA9F CRC64; MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL QRAEQSPQPT IPIVGIVAGL VVLGAVVTGA VVAAVMWRKK SSGRKGSHKS QGKV // ID A0A0G2JNX1_HUMAN Unreviewed; 246 AA. AC A0A0G2JNX1; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 20-JUN-2018, entry version 22. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain G {ECO:0000313|Ensembl:ENSP00000482272}; GN Name=HLA-G {ECO:0000313|Ensembl:ENSP00000482272}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000482272, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000482272, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000482272} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR925767; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; A0A0G2JNX1; -. DR Ensembl; ENST00000612360; ENSP00000479043; ENSG00000276051. DR Ensembl; ENST00000618039; ENSP00000482272; ENSG00000276051. DR HGNC; HGNC:4964; HLA-G. DR ChiTaRS; HLA-G; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A0G2JNX1, KW ECO:0000213|PeptideAtlas:A0A0G2JNX1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 246 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014514187. FT TRANSMEM 216 240 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 117 195 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 246 AA; 27710 MW; D0A8F93F39203909 CRC64; MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM NLQTLRGYYN QSEANPPKTH VTHHPVFDYE ATLRCWALGF YPAEIILTWQ RDGEDQTQDV ELVETRPAGD GTFQKWAAVV VPSGEEQRYM CHVQHEGLPE PLMLRWKQSS LPTIPIMGIV AGLVVLAAVV TGAAVAAVLW RKKSSD // ID A0A0G2JPA3_HUMAN Unreviewed; 346 AA. AC A0A0G2JPA3; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 23-MAY-2018, entry version 20. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000483269}; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000483269}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000483269, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000483269, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000483269} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759790; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A0G2JPA3; -. DR PeptideAtlas; A0A0G2JPA3; -. DR Ensembl; ENST00000622145; ENSP00000483269; ENSG00000234487. DR HGNC; HGNC:4963; HLA-F. DR OrthoDB; EOG091G09OH; -. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A0G2JPA3, KW ECO:0000213|PeptideAtlas:A0A0G2JPA3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 346 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002546377. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 284 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 346 AA; 38997 MW; 70739E07A66523FF CRC64; MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL QRADPPKAHV AHHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPQP LILRWEQSPQ PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSGRKGSH KSQGKV // ID A0A0G2JPD3_HUMAN Unreviewed; 394 AA. AC A0A0G2JPD3; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 23-MAY-2018, entry version 20. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000483385}; GN Name=HLA-A {ECO:0000313|Ensembl:ENSP00000483385}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000483385, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000483385, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] {ECO:0000313|Ensembl:ENSP00000483385} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL845454; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A0G2JPD3; -. DR PeptideAtlas; A0A0G2JPD3; -. DR Ensembl; ENST00000616730; ENSP00000483385; ENSG00000206505. DR HGNC; HGNC:4931; HLA-A. DR OrthoDB; EOG091G09OH; -. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A0G2JPD3, KW ECO:0000213|MaxQB:A0A0G2JPD3, ECO:0000213|PeptideAtlas:A0A0G2JPD3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 394 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002546781. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 394 AA; 44426 MW; A6DC7C2CEC93C0FE CRC64; MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WETAHEAEQW RAYLEGRCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKGESLEG LMCVGCWAEQ WTQLCYGVSL HWMY // ID A0A0G2JPQ3_HUMAN Unreviewed; 343 AA. AC A0A0G2JPQ3; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 23-MAY-2018, entry version 20. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain G {ECO:0000313|Ensembl:ENSP00000484084}; GN Name=HLA-G {ECO:0000313|Ensembl:ENSP00000484084}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000484084, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000484084, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000484084} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR925767; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A0G2JPQ3; -. DR PeptideAtlas; A0A0G2JPQ3; -. DR Ensembl; ENST00000615464; ENSP00000484084; ENSG00000276051. DR HGNC; HGNC:4964; HLA-G. DR OrthoDB; EOG091G09OH; -. DR ChiTaRS; HLA-G; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:A0A0G2JPQ3, KW ECO:0000213|MaxQB:A0A0G2JPQ3, ECO:0000213|PeptideAtlas:A0A0G2JPQ3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 343 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002546198. FT TRANSMEM 313 337 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 343 AA; 38868 MW; C0F7DC65397AE9C5 CRC64; MKTPRMVVMA PRTLFLLLSG ALTLTETWAG SHSMRYFSAA VSRPGRGEPR FIAMGYVDDT QFVRFDSDSA CPRMEPRAPW VEQEGPEYWE EETRNTKAHA QTDRMNLQTL RGYYNQSEAS SHTLQWMIGC DLGSDGRLLR GYEQYAYDGK DYLALNEDLR SWTAADTAAQ ISKRKCEAAN VAEQRRAYLE GTCVEWLHRY LENGKEMLQR ADPPKTHVTH HPVFDYEATL RCWALGFYPA EIILTWQRDG EDQTQDVELV ETRPAGDGTF QKWAAVVVPS GEEQRYMCHV QHEGLPEPLM LRWKQSSLPT IPIMGIVAGL VVLAAVVTGA AVAAVLWRKK SSD // ID A0A0G2JW06_RAT Unreviewed; 288 AA. AC A0A0G2JW06; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 12-SEP-2018, entry version 21. DE SubName: Full=RT1 class Ib, locus M5 {ECO:0000313|Ensembl:ENSRNOP00000069692}; GN Name=RT1-M5 {ECO:0000313|Ensembl:ENSRNOP00000069692, GN ECO:0000313|RGD:1595816}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000069692, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000069692, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000069692, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000069692} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000069692}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC108572; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSRNOT00000082965; ENSRNOP00000069692; ENSRNOG00000033136. DR RGD; 1595816; RT1-M5. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000033136; Expressed in 3 organ(s), highest expression level in testis. DR ExpressionAtlas; A0A0G2JW06; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 239 261 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 141 229 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 288 AA; 32394 MW; 01DB624365F8E53D CRC64; MEPRALWVKN MGPGYWERQT RMVKDISKNS LVNLREAMSV YNHSEDGTHV FQCVSGCDVG PDGLFLRGHE QHAYDGRDYL ALNKDLHSWT AGDTAAQITR RKWEEAGVAE QRRTYLKGEC VESLRTYLEI GKETLLGADP PKAHVTHHPS PEGDNTLRCW ALGFYPSDIT LTWQRDGEDL TQDMELVETR PGGDGTFQKW AAVVVPSGEE HRYTCCVEHE GLTEPLLLKW DPSKHTIPIM GITAGLVFLG VAFTGAVVAI AMRKQRGCRV LTPSKAHLER SDKYLTWT // ID A0A0G2JZI7_RAT Unreviewed; 346 AA. AC A0A0G2JZI7; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 12-SEP-2018, entry version 21. DE SubName: Full=RT1 class I, locus CE11-like {ECO:0000313|Ensembl:ENSRNOP00000071062}; GN Name=LOC100364500 {ECO:0000313|Ensembl:ENSRNOP00000071062, GN ECO:0000313|RGD:2320860}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000071062, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000071062, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071062, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000071062} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071062}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044333; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_006255954.2; XM_006255892.3. DR Ensembl; ENSRNOT00000082052; ENSRNOP00000071062; ENSRNOG00000048951. DR GeneID; 100364500; -. DR KEGG; rno:100364500; -. DR RGD; 2320860; LOC100364500. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000048951; Expressed in 9 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; A0A0G2JZI7; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 285 309 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 182 270 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 346 AA; 38798 MW; 19348CACDF8DAE93 CRC64; MRCFKTAVSR PGLGEPRFIA VAYVDDTEFV RYDGDAENPR TEPRARWMER EGPEYWEEET RKIKGQEQWF RMSLRILRGY YNQSEGGSHT FQKMSGCDVG SDGSLLRGYN QYAYDGHDYI ALNKDLKTWT AADFAALITK TKWDQAGTAE RKRAYLEGTC XVEWLRRYLE LGKETLLRSD PPKAHVTLHP RPEGDVTLRC WALGFYPADI TLTWQLNGED LTQDMELVET RPAGDGTFQK WAAVVVPLGK EQNYTCLVEH EGLPEPLTLR WEAPPGTDSN METKVIYVVL GAVAMIGAVA VIGAVVAVVR RRRRKRNTGG TGGDYAPAPG SDSCQSSDVS LADCEA // ID A0A0G2K0R1_RAT Unreviewed; 372 AA. AC A0A0G2K0R1; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 12-SEP-2018, entry version 24. DE SubName: Full=RT1 class I, locus M6, gene 1 {ECO:0000313|Ensembl:ENSRNOP00000071549}; GN Name=RT1-M6-1 {ECO:0000313|Ensembl:ENSRNOP00000071549, GN ECO:0000313|RGD:1598232}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000071549, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000071549, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071549, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000071549} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071549}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC108572; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSRNOT00000086007; ENSRNOP00000071549; ENSRNOG00000022107. DR RGD; 1598232; RT1-M6-1. DR GeneTree; ENSGT00760000118960; -. DR OMA; CIALKED; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000022107; Expressed in 9 organ(s), highest expression level in testis. DR ExpressionAtlas; A0A0G2K0R1; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 372 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002546806. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 372 AA; 41766 MW; 2BC476AEEBC3C461 CRC64; MGAPVLHATL LLLSAFLALT QTKNQSFAGS HFMQYLVTTT SSQPGLQDSH VCIVGHVDYM PFMRFDSDGA AQRIQTRGPW MKQMGPEYLE MERKNAEGYS HRARENLRFA IQVYNQSDKV SHTFQCLIGC DMGPDGRLLQ AHYSHAFDGQ HYISLNSDLT TWSVGDSTAQ ITKRRWEADG VAEALSHFLK VSCVEHLQKH LETGKETLQR SDPPKAHVTL HPRPEGDVTL RCWALGFYPA DITLTWQLNG EDLTQDMELV ETRPAGDGTF QKWASVVVPN GEEQKYTCLV EHEGLPEPLT LRWKPATWPV VGITVGVVLL GFVTIGALIA IVTMRKKRAG KEGIVSEDFH RFEALHGNVF IAHFITLRHL YV // ID A0A0G2K1E1_RAT Unreviewed; 382 AA. AC A0A0G2K1E1; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 12-SEP-2018, entry version 24. DE SubName: Full=RT1 class Ia, locus A1 {ECO:0000313|Ensembl:ENSRNOP00000071804}; GN Name=RT1-A1 {ECO:0000313|Ensembl:ENSRNOP00000071804, GN ECO:0000313|RGD:1595924}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000071804, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000071804, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071804, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000071804} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071804}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044421; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044422; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044423; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044424; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSRNOT00000080900; ENSRNOP00000071804; ENSRNOG00000038999. DR RGD; 1595924; RT1-A1. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000038999; Expressed in 9 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; A0A0G2K1E1; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; IPI:RGD. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0042277; F:peptide binding; IDA:RGD. DR GO; GO:0046982; F:protein heterodimerization activity; IPI:RGD. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0045953; P:negative regulation of natural killer cell mediated cytotoxicity; IMP:RGD. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:RGD. DR GO; GO:0002657; P:positive regulation of tolerance induction to nonself antigen; IMP:RGD. DR GO; GO:0002517; P:T cell tolerance induction; IMP:RGD. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A0G2K1E1}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 382 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002546575. FT TRANSMEM 312 335 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 382 AA; 42909 MW; 9C876AD2CC0C633A CRC64; MGAMAPRTLL LILAAALAPT QTRAGSHSMR YFDIAVSRPG LGEPRFIIVG YVDDTEFVRF DSDAEKPRYE PRAPWMEPEG PEYWEEQTRR AKEGEQTFRV NLRTALHYYN QSEDRSHTIQ RLSGCDVGSD GRLLRGYEQY AYDGRDYIAL NEDLKTWTAA DFAARISRNK WDQAGVAERL RAYLEGECVE WLRRYLELGK ETLLRSDPPK AHVTLHPRPE GDVTLRCWAL GFYPADITLT WQLNGEDLTQ DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCRVEHEGL PEPLSQRWEP PPSTDSNMET TVIYVVLGAV AIIAAVIIGA VVTVVRKRRR NTGGKGVYTP APGTDSSQSS DVSLPDCKGD TMGSNWGGTM WT // ID A0A0G2K2E1_RAT Unreviewed; 368 AA. AC A0A0G2K2E1; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 12-SEP-2018, entry version 24. DE SubName: Full=RT1 class Ia, locus A1 {ECO:0000313|Ensembl:ENSRNOP00000072208}; GN Name=RT1-A1 {ECO:0000313|Ensembl:ENSRNOP00000072208, GN ECO:0000313|RGD:1595924}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000072208, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000072208, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000072208, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000072208} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000072208}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044421; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044422; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044423; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044424; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSRNOT00000082538; ENSRNOP00000072208; ENSRNOG00000038999. DR RGD; 1595924; RT1-A1. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000038999; Expressed in 9 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; A0A0G2K2E1; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0030881; F:beta-2-microglobulin binding; IPI:RGD. DR GO; GO:0042277; F:peptide binding; IDA:RGD. DR GO; GO:0046982; F:protein heterodimerization activity; IPI:RGD. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0045953; P:negative regulation of natural killer cell mediated cytotoxicity; IMP:RGD. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:RGD. DR GO; GO:0002657; P:positive regulation of tolerance induction to nonself antigen; IMP:RGD. DR GO; GO:0002517; P:T cell tolerance induction; IMP:RGD. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A0G2K2E1}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 368 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002546623. FT TRANSMEM 309 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 41655 MW; CF1419E7FC434751 CRC64; MAPRTLLLLL AAALAPTQTR AGSHSLRYFT TAVSRPGLRE PRYMEVGYVD DTEFVRYDSD AENPRMEPRV RWMELEGPEY WQRETQRAKG NQQWFRVDLR TLLRYYNQSE GGSHTIQRLS GCDVGSDGRL LRGYEQYAYD GRDYIALNED LKTWTAADFA ARISRNKWDQ AGVAERLRAY LEGECVEWLR RYLELGKETL LRSDPPKAHV TLHPRPEGDV TLRCWALGFY PADITLTWQL NGEDLTQDME LVETRPAGDG TFQKWASVVV PLGKEQNYTC RVEHEGLPEP LSQRWEPPPS TDSNMETTVI YVVLGAVAII AAVIIGAVVT VVRKRRRNTG GKGRVCFPSA SCTDSSQSSD VSLPDCKA // ID A0A0G2K4S5_RAT Unreviewed; 372 AA. AC A0A0G2K4S5; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 12-SEP-2018, entry version 23. DE SubName: Full=RT1 class I, locus CE4 {ECO:0000313|Ensembl:ENSRNOP00000073153}; GN Name=RT1-CE4 {ECO:0000313|Ensembl:ENSRNOP00000073153, GN ECO:0000313|RGD:1598234}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000073153, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000073153, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073153, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000073153} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073153}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044397; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044398; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044399; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044400; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044401; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044402; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044403; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044404; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044405; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044406; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSRNOT00000082497; ENSRNOP00000073153; ENSRNOG00000039744. DR RGD; 1598234; RT1-CE4. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000039744; Expressed in 9 organ(s), highest expression level in spleen. DR ExpressionAtlas; A0A0G2K4S5; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 372 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002547195. FT TRANSMEM 309 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 372 AA; 42133 MW; 9C4F57F873E12382 CRC64; MAPPTLLLLV AAALTPTKTR AGSHSLRYFH TAVSRPGLGE PRFISVGYVD DTEFVRYDSD AENPRYEPRA RWMEREGPEY WERQTQIAKR NEQVYRVDLS TLRGYYNQSE GGSHTYQRMH GCELGSDGSL LRGYMQYAYD GRDYIALNED LKTWMVKDTA ARITRNKWDQ AGFGERKRTY LQVECLEWLR KYLELGKETL LRSDPPKAHV TLHPRPEGDV TLRCWALGFY PADITLTWQL NGEDLTQDME LVETRPAGDG TFQKWASVVV PLGKEQNYTC LVEHEGLPEP LTFRWEAPPS TNSNTGMSVI LGTVTIIAVM AIIVVVAVIR TVVRKRWIKT AFLLTSGKGV YTPAPGRDSS QSSDVSLPDC KA // ID A0A0G2K4X1_RAT Unreviewed; 356 AA. AC A0A0G2K4X1; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 12-SEP-2018, entry version 24. DE SubName: Full=RT1 class Ia, locus A1 {ECO:0000313|Ensembl:ENSRNOP00000073206}; GN Name=RT1-A1 {ECO:0000313|Ensembl:ENSRNOP00000073206, GN ECO:0000313|RGD:1595924}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000073206, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000073206, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073206, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000073206} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073206}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044421; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044422; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044423; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044424; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSRNOT00000089306; ENSRNOP00000073206; ENSRNOG00000038999. DR RGD; 1595924; RT1-A1. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000038999; Expressed in 9 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; A0A0G2K4X1; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0030881; F:beta-2-microglobulin binding; IPI:RGD. DR GO; GO:0042277; F:peptide binding; IDA:RGD. DR GO; GO:0046982; F:protein heterodimerization activity; IPI:RGD. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0045953; P:negative regulation of natural killer cell mediated cytotoxicity; IMP:RGD. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:RGD. DR GO; GO:0002657; P:positive regulation of tolerance induction to nonself antigen; IMP:RGD. DR GO; GO:0002517; P:T cell tolerance induction; IMP:RGD. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A0G2K4X1}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 356 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002547138. FT TRANSMEM 299 322 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 196 282 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 356 AA; 40022 MW; D1886541FB34B4F5 CRC64; MAPRTLLLLL AAALAPTQTR AGSHSLRYFV TAVSRPGLGE PRQFVRYDSD AENPRYEPRA PWMEREGPEY WERETQNAKR NEQVYRVDLR TALRYYNQSE GGSHTIQRMY GCDMGSDGSL LRGYYQDAYD GRDYIALNED LKTWTAADFA AQITRSKWDQ AGVAERLRAY LEGTCVEWLR RYLELGKETL LRSDPPKAHV TLHPRPEGDV TLRCWALGFY PADITLTWQL NGEDLTQDME LVETRPAGDG TFQKWASVVV PLGKEQNYTC RVEHEGLPEP LSQRWEPPPS TDSNMETTVI YVVLGAVAII AAVIIGAVVT VVRKRRRNTG GKGVYTPAPG TDSSQSSDVS LPDCKA // ID A0A0G2K4Y5_RAT Unreviewed; 279 AA. AC A0A0G2K4Y5; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 12-SEP-2018, entry version 21. DE SubName: Full=RT1 class Ib, locus M5 {ECO:0000313|Ensembl:ENSRNOP00000073221}; GN Name=RT1-M5 {ECO:0000313|Ensembl:ENSRNOP00000073221, GN ECO:0000313|RGD:1595816}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000073221, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000073221, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073221, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000073221} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073221}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC108572; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSRNOT00000080237; ENSRNOP00000073221; ENSRNOG00000033136. DR RGD; 1595816; RT1-M5. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000033136; Expressed in 3 organ(s), highest expression level in testis. DR ExpressionAtlas; A0A0G2K4Y5; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 239 262 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 141 229 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 279 AA; 31452 MW; FA1E06C2C300934B CRC64; MEPRALWVKN MGPGYWERQT RMVKDISKNS LVNLREAMSV YNHSEDGTHV FQCVSGCDVG PDGLFLRGHE QHAYDGRDYL ALNKDLHSWT AGDTAAQITR RKWEEAGVAE QRRTYLKGEC VESLRTYLEI GKETLLGADP PKAHVTHHPS PEGDNTLRCW ALGFYPSDIT LTWQRDGEDL TQDMELVETR PGGDGTFQKW AAVVVPSGEE HRYTCCVEHE GLTEPLLLKW DPSKHTIPIM GITAGLVFLG VAFTGAVVAI AMRKQRAHLE RSDKYLTWT // ID A0A0G2K731_RAT Unreviewed; 176 AA. AC A0A0G2K731; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 12-SEP-2018, entry version 22. DE SubName: Full=RT1 class I, locus M6, gene 1 {ECO:0000313|Ensembl:ENSRNOP00000074041}; DE Flags: Fragment; GN Name=RT1-M6-1 {ECO:0000313|Ensembl:ENSRNOP00000074041, GN ECO:0000313|RGD:1598232}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000074041, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000074041, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074041, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000074041} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074041}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC108572; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSRNOT00000077774; ENSRNOP00000074041; ENSRNOG00000022107. DR RGD; 1598232; RT1-M6-1. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000022107; Expressed in 9 organ(s), highest expression level in testis. DR ExpressionAtlas; A0A0G2K731; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}. FT DOMAIN 1 176 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 176 176 {ECO:0000313|Ensembl:ENSRNOP00000074041}. SQ SEQUENCE 176 AA; 20037 MW; 6E9987B8C9849398 CRC64; MQYLVTTTSS QPGLQDSHVC IVGHVDYMPF MRFDSDGAAQ RIQTRGPWMK QMGPEYLEME RKNAEGYSHR ARENLRFAIQ VYNQSDKVSH TFQCLIGCDM GPDGRLLQAH YSHAFDGQHY ISLNSDLTTW SVGDSTAQIT KRRWEADGVA EALSHFLKVS CVEHLQKHLE TGKETL // ID A0A0G2K7F4_RAT Unreviewed; 268 AA. AC A0A0G2K7F4; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 12-SEP-2018, entry version 21. DE SubName: Full=Class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like {ECO:0000313|Ensembl:ENSRNOP00000074183}; DE Flags: Fragment; GN Name=LOC103690108 {ECO:0000313|Ensembl:ENSRNOP00000074183}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000074183, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000074183, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074183, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000074183} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074183}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044383; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSRNOT00000086293; ENSRNOP00000074183; ENSRNOG00000047706. DR RGD; 9113230; LOC103690108. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000047706; Expressed in 9 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; A0A0G2K7F4; baseline and differential. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A0G2K7F4}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 268 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002546981. FT DOMAIN 209 268 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 268 268 {ECO:0000313|Ensembl:ENSRNOP00000074183}. SQ SEQUENCE 268 AA; 30373 MW; 73A537BD5AE96D34 CRC64; MGAMAPRTLL LLLAAALAPT QTRAGSHSLR YFVTAISGPG LGEPRFMEVG YVDGTEFVRY DSDAKNPGME PRARWMEREG REYWERETRR VKENEQLFRG NLRTLLGYYN QSEGGSHTIQ WMSGCDVGSD GSLLRGYDQF AYDGRDYIVL NEDLKTWTAA DTAARITRNK WDRAGVAERH KAYLEGKCLE SLLRYLELGK ETLLRSDPPK AHVTLHPRPE GDVTLRCWAL GFYPAGISLT WQLNGEDLTQ DMELVETRPA GDGTFQKW // ID A0A0G2K7V7_RAT Unreviewed; 372 AA. AC A0A0G2K7V7; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 12-SEP-2018, entry version 25. DE SubName: Full=MHC class I polypeptide-related sequence B {ECO:0000313|Ensembl:ENSRNOP00000074366}; GN Name=Micb {ECO:0000313|Ensembl:ENSRNOP00000074366, GN ECO:0000313|RGD:1564508}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000074366, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000074366, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074366, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000074366} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074366}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC093995; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC110846; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSRNOT00000083211; ENSRNOP00000074366; ENSRNOG00000057645. DR RGD; 1564508; Micb. DR GeneTree; ENSGT00740000114936; -. DR OMA; LVLQSHW; -. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000002494; Chromosome 1. DR Bgee; ENSRNOG00000057645; Expressed in 9 organ(s), highest expression level in lung. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 372 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002547003. FT DOMAIN 192 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 372 AA; 41001 MW; 45DA7F1DA95C7A81 CRC64; MEASSGTAGP AVLLLILALL LTESQGSRSQ GTHTLRYDVT ACFLEGSEQT RLLVLIYVDD ELFLRYNGDR RSAKPWACWI KGHGGDETCT REAENLPKEE ERLREMMADM INQKGHDKGP YTLQATLDCE LQRNGSTRGF WHLGYEGRNL LTFDQKTLTW TMDVPFTQQK KTFEPRAPKA DLVKTFLDET CPARLQRHLA SLSNVLPDTG SPVVIVTCRN YPVGRITLTC RAFNLSSRVA TLLWLRDGKP VQQDVFGPGT ILPSGDGTYQ TWVSIRVLPG QEPQFACNLR HSNRTIMQTA VSGESMGWPS ASWATRQEAE GPHRTHNDHV VDGGLVTGNA NKDSPDASSC ATASAISAFP VVVLSVALPR AN // ID A0A0G2K8A3_RAT Unreviewed; 242 AA. AC A0A0G2K8A3; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 4. DT 12-SEP-2018, entry version 22. DE SubName: Full=RT1 class I, locus M6, gene 2 {ECO:0000313|Ensembl:ENSRNOP00000074529}; DE Flags: Fragment; GN Name=RT1-M6-2 {ECO:0000313|Ensembl:ENSRNOP00000074529, GN ECO:0000313|RGD:1595815}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000074529, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000074529, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074529, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000074529} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074529}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC108572; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSRNOT00000079838; ENSRNOP00000074529; ENSRNOG00000040052. DR RGD; 1595815; RT1-M6-2. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000040052; Expressed in 9 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; A0A0G2K8A3; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 210 234 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 114 204 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 242 242 {ECO:0000313|Ensembl:ENSRNOP00000074529}. SQ SEQUENCE 242 AA; 27323 MW; FA4D089CE4882C1C CRC64; MRRGIHTGLE KTCDSQSRSI TRAIKCLIGC DMGPDGRLLQ GHHRHAFDGQ HYISLNSDLT TWSVADSTAQ ITKRRWEADG VAEAFSHFLK VSCVEWLQKH LETGKETLQR SDPPKTHVTH HPRPEGDATL RCWALDFYPA DITLTWQEEE EEEELTQDME LVETRPAGDG TFQKWASVVV PSGEEQKYTC HVYHEGLPEP LTLRWKPATW PVVGITVGVV LLGFVTIGAL IAIVTMRKKR AE // ID A0A0G2K8A4_RAT Unreviewed; 316 AA. AC A0A0G2K8A4; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 12-SEP-2018, entry version 24. DE SubName: Full=RT1 class I, locus T24, gene 3 {ECO:0000313|Ensembl:ENSRNOP00000074530}; GN Name=RT1-T24-3 {ECO:0000313|Ensembl:ENSRNOP00000074530, GN ECO:0000313|RGD:1624211}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000074530, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000074530, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074530, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000074530} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074530}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044364; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 10116.ENSRNOP00000064880; -. DR PaxDb; A0A0G2K8A4; -. DR Ensembl; ENSRNOT00000078454; ENSRNOP00000074530; ENSRNOG00000045924. DR RGD; 1624211; RT1-T24-3. DR GeneTree; ENSGT00740000114936; -. DR OMA; RKWEALG; -. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000045924; Expressed in 9 organ(s), highest expression level in spleen. DR ExpressionAtlas; A0A0G2K8A4; baseline and differential. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}. FT DOMAIN 192 280 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 316 AA; 36701 MW; 06637107785B3846 CRC64; SHSLHYSYSA VTEPGPGVPA FFASGFVDNQ PFIHYDSRKM EAEPCADWLR ENPYYFDEET QVFTNRMKIF QLSLRNIQQY YNSSGDRSQR ADGFHQQAGP HTLQFTYGCE MQDNRTTGHW QYGYDGRDYL TLDLDSMQYT AATFIAGYTK HKWQNNEYWL EREKTYLEKE CVLWLKRYLT MGGENFTRTD PPQTTVTCHP RPEGDVTLRC WALGFYPADI TLTWQLNGED LTQDMELVET RPAGDGTFQK WASVVVPLGK EQKYTCRVEH EGLPEPVSLT WEPLQLTTSK TEVCARGRWG LQATTLCVLM VFWAWC // ID A0A0G2K8G8_RAT Unreviewed; 367 AA. AC A0A0G2K8G8; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 12-SEP-2018, entry version 24. DE SubName: Full=RT1 class Ia, locus A1 {ECO:0000313|Ensembl:ENSRNOP00000074602}; GN Name=RT1-A1 {ECO:0000313|Ensembl:ENSRNOP00000074602, GN ECO:0000313|RGD:1595924}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000074602, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000074602, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074602, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000074602} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074602}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044421; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044422; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044423; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044424; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSRNOT00000081240; ENSRNOP00000074602; ENSRNOG00000038999. DR RGD; 1595924; RT1-A1. DR GeneTree; ENSGT00760000118960; -. DR OMA; HIFQRIH; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000038999; Expressed in 9 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; A0A0G2K8G8; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0030881; F:beta-2-microglobulin binding; IPI:RGD. DR GO; GO:0042277; F:peptide binding; IDA:RGD. DR GO; GO:0046982; F:protein heterodimerization activity; IPI:RGD. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0045953; P:negative regulation of natural killer cell mediated cytotoxicity; IMP:RGD. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:RGD. DR GO; GO:0002657; P:positive regulation of tolerance induction to nonself antigen; IMP:RGD. DR GO; GO:0002517; P:T cell tolerance induction; IMP:RGD. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A0G2K8G8}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 367 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002547019. FT TRANSMEM 309 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 367 AA; 41351 MW; A7C0DD97395155A3 CRC64; MAPRTLLLLL AAALAPTQTR AGSHSLRYFV TAVSRPGLGE PRYMEVGYVD DTQFVRYDSD AENPRYEPRA PWMEREGPEY WERETQNAKR NEQVYRVDLR TALRYYNQSE GGSHTIQRMY GCDMGSDGSL LRGYYQDAYD GRDYIALNED LKTWTAADFA AQITRSKWDQ AGVAERLRAY LEGTCVEWLR RYLELGKETL LRSDPPKAHV TLHPRPEGDV TLRCWALGFY PADITLTWQL NGEDLTQDME LVETRPAGDG TFQKWASVVV PLGKEQNYTC RVEHEGLPEP LSQRWEPPPS TDSNMETTVI YVVLGAVAII AAVIIGAVVT VVRKRRRNTG RKGGVYTPAP GTDSSQSSDV SLPDCKA // ID A0A0G2K8R6_RAT Unreviewed; 371 AA. AC A0A0G2K8R6; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 12-SEP-2018, entry version 23. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSRNOP00000074709}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000074709, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000074709, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074709, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000074709} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074709}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044397; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044398; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044399; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044400; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044401; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044402; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044403; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044404; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044405; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSRNOT00000091344; ENSRNOP00000074709; ENSRNOG00000061639. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000050183; Expressed in 9 organ(s), highest expression level in lung. DR ExpressionAtlas; A0A0G2K8R6; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 371 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002546828. FT TRANSMEM 312 338 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 371 AA; 41642 MW; EAAA883B441B2A1C CRC64; MGVTAPPLLL LLLAAALART QTRAGSHSLR YFKTAVSRPG LGEPRFMEVG YVDDTEFVRF DSDAENPRYE PRVRWMERQR PEYWERETQG AKEKEQTFRV NLRTLLGYYN QSEGDSHTLQ LMFGCDVGSD GRLLRGYDQF AYDGRDYIAL NEDLKTWAAA DVVAQMTRNK WERARYAEKR RANLEGECVE SLRRYLELGK ETLLRSDPPK AHVTLHPRPE GDVTLRCWAL GFYPADITLT WQLNGEDLTQ DMELVETRPA GDGTFQKWAA VVVPLGKEQN YTCHMEHEGL PEPLTLRWEA PPSTNSNMEF NVIYVVLGAI SAVAIIGAVI IGAVLAVVRK RNTGGTGGDY TPAPGKDSCQ SSDVSLADCE A // ID A0A0G2KA70_RAT Unreviewed; 299 AA. AC A0A0G2KA70; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 12-SEP-2018, entry version 23. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSRNOP00000075284}; DE Flags: Fragment; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000075284, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000075284, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000075284, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000075284} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000075284}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044364; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSRNOT00000078110; ENSRNOP00000075284; ENSRNOG00000000787. DR GeneTree; ENSGT00740000114936; -. DR OMA; ISMENEC; -. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000000787; Expressed in 9 organ(s), highest expression level in lung. DR ExpressionAtlas; A0A0G2KA70; baseline and differential. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}. FT DOMAIN 210 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 299 299 {ECO:0000313|Ensembl:ENSRNOP00000075284}. SQ SEQUENCE 299 AA; 34846 MW; 0E1FF0117E06C753 CRC64; MWSLIFCFLS HPQDTGARSH SLHYSYSAVT EPGPGVPAFF ASGFVDNQPF IHYDSRKMEA EPCADWLREN PYYLADETQV FTNWMKTLQL SLRNIQQYYN SSGDRSQRAD GFHQQAGPHT LQFTYGCEMQ DNRTTGHWHY GYDGRDYLTL DLDSMQYTAA TFIAGYTKHK WQNNEYWLER EKTYLEKECV LWLKRYLTMG GENFTRTDPP RTTVTHHPRP EGDVTLRCWA LGFYPADITL TWQLNGEDLT QEMELVETRP AGDGTFQKWA SVVVPSGEEQ KYTCRVEHEG LPEPLTLRW // ID A0A0G2KA93_RAT Unreviewed; 320 AA. AC A0A0G2KA93; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 12-SEP-2018, entry version 23. DE SubName: Full=RT1 class I, locus T24, gene 1 {ECO:0000313|Ensembl:ENSRNOP00000075312}; DE Flags: Fragment; GN Name=RT1-T24-1 {ECO:0000313|Ensembl:ENSRNOP00000075312, GN ECO:0000313|RGD:1359499}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000075312, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000075312, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000075312, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000075312} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000075312}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044364; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSRNOT00000089044; ENSRNOP00000075312; ENSRNOG00000032596. DR RGD; 1359499; RT1-T24-1. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000032596; Expressed in 9 organ(s), highest expression level in spleen. DR ExpressionAtlas; A0A0G2KA93; baseline and differential. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}. FT DOMAIN 210 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 320 320 {ECO:0000313|Ensembl:ENSRNOP00000075312}. SQ SEQUENCE 320 AA; 37067 MW; 60EDEEE2CC487DB9 CRC64; MWSLIFCFLS HPQDTGARSH SLHYSYSAVT EPGPGVPAFF ASGFVDNQTF IHYDSRKMEA EPCADWLREN PYYFDEETQV FTNQMKIFQL SLRNIQQYYN SSGDRSHRAD GFHQQAGPHT LQFTYGCEMQ GNRTTGHWQY GYDGRDYLTL DLDSMQYTAA TFIAGYTKHK WQNNEYWLER EKTYLEKECV LWLKRYLTMG GENFTRTDPP QTTVTHHPRP EGDVTLRCWA LGFYPADITL TWQLNGEDLT QDMELVETRP TGDGTFQKWA AVVVPLGKEQ KYTCHVEHEG LPEPLTQRWE APPGTDSNMG INVIAVFFKL // ID A0A0H2UHB9_RAT Unreviewed; 353 AA. AC A0A0H2UHB9; DT 16-SEP-2015, integrated into UniProtKB/TrEMBL. DT 16-SEP-2015, sequence version 1. DT 12-SEP-2018, entry version 29. DE SubName: Full=MHC class I-like sequence (Mapped) {ECO:0000313|EMBL:EDM09513.1}; DE SubName: Full=Major histocompatibility complex class I-related gene protein {ECO:0000313|Ensembl:ENSRNOP00000004694}; GN Name=Mr1 {ECO:0000313|Ensembl:ENSRNOP00000004694, GN ECO:0000313|RGD:1593291}; GN Synonyms=Hlals_mapped {ECO:0000313|EMBL:EDM09513.1}; GN ORFNames=rCG_46204 {ECO:0000313|EMBL:EDM09513.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000004694, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000004694, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000004694, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|EMBL:EDM09513.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDM09513.1}; RX PubMed=15632090; DOI=10.1101/gr.2889405; RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., RA Istrail S., Li P., Sutton G.; RT "Gene and alternative splicing annotation with AIR."; RL Genome Res. 15:54-66(2005). RN [3] {ECO:0000313|EMBL:EDM09513.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDM09513.1}; RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., RA Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., RA Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSRNOP00000004694} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000004694}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07021452; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07021453; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH473958; EDM09513.1; -; Genomic_DNA. DR UniGene; Rn.163225; -. DR Ensembl; ENSRNOT00000004694; ENSRNOP00000004694; ENSRNOG00000003522. DR RGD; 1593291; Mr1. DR GeneTree; ENSGT00740000114936; -. DR OMA; GYVDSHP; -. DR Proteomes; UP000002494; Chromosome 13. DR Bgee; ENSRNOG00000003522; Expressed in 9 organ(s), highest expression level in spleen. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 353 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015233147. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 312 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 168 188 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 353 AA; 40698 MW; AF24D84D755F634B CRC64; MGRKGLQWGL MMFLLPFLTV FLAKQSHTRT HSLRYFRLAI SDPGPGVPEF ISVGYVDSHP ITTYDSVTRQ KEPRAPWMAE NLAPDHWERY TQLLRGWQRT FQTELRHLQR HYNHSGLHTY QRMIGCELLE DGSTTGFLQY AYDGQDFIVF DKDTLSWLAM DNVAHITKRA WEANLHELQY QKNWLEEECI AWLKRFLEYG SDALERTEHP VVRTTRKETF PGITTLFCRA HGFYPPEISM IWKKNGEEIV QEVDYGGVLP SGDGTYQMWV SVDLDPQTKD IYSCHVEHCG LQMVLEAPQE SGNTLLVANT ISGTIILIIV LAGVGALIWR RRSREPKEVM YQPTQVNEGS SPS // ID A0A0N4SU34_DANRE Unreviewed; 331 AA. AC A0A0N4SU34; DT 09-DEC-2015, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 12-SEP-2018, entry version 21. DE SubName: Full=Major histocompatibility complex class I ZAA {ECO:0000313|Ensembl:ENSDARP00000135947}; GN Name=mhc1zaa {ECO:0000313|Ensembl:ENSDARP00000135947}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000135947, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000135947, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000135947, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [2] {ECO:0000313|Ensembl:ENSDARP00000135947} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000135947}; RG Ensembl; RL Submitted (NOV-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CU394254; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSDART00000158560; ENSDARP00000135947; ENSDARG00000092162. DR ZFIN; ZDB-GENE-030916-1; mhc1zaa. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000000437; Chromosome 3. DR Bgee; ENSDARG00000074765; Expressed in 15 organ(s), highest expression level in spleen. DR ExpressionAtlas; A0A0N4SU34; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A0N4SU34}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 331 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015321203. FT DOMAIN 218 305 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 331 AA; 38773 MW; 5A78F2AAA3181B0A CRC64; MMSGGVASGI CALLCVFLLC GDLPSAQGEK HSLYYIYTSL SKPLDLPGIY EFSAMGLLDD RQIDSYNSEE QRKIPKQQWM KEKMQEDYWE KGTWSRKSKE QWFNVNVHIL MERMRHNMSD LHILQWRHGC EVEIQGSEVK FSKGVSEYGY DGENLLYFDD AESRWVAPVE EALPTKRKWD NIPILNQYTK GYLEKECVDW LNKFREYADE ELRKASPPDV YKLTKKSTKD ETKLKLTCLA TGFYPNDVML NIRRNCLPED ETESTGVRPN HDQTFQLRKS VEIKEDQIDE YDCHLTHRTL KNPVTATRAK QRGIESWNLF FTYGALHIWC C // ID A0A0N8JUU7_9TELE Unreviewed; 169 AA. AC A0A0N8JUU7; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 25-OCT-2017, entry version 6. DE SubName: Full=HLA class I histocompatibility antigen, A-32 alpha chain-like {ECO:0000313|EMBL:KPP56329.1}; DE Flags: Fragment; GN ORFNames=Z043_126069 {ECO:0000313|EMBL:KPP56329.1}; OS Scleropages formosus (Asian bonytongue). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala; OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages. OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP56329.1, ECO:0000313|Proteomes:UP000034805}; RN [1] {ECO:0000313|EMBL:KPP56329.1, ECO:0000313|Proteomes:UP000034805} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP56329.1}; RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.; RT "The genome of the Asian arowana (Scleropages formosus)."; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KPP56329.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JARO02022302; KPP56329.1; -; Genomic_DNA. DR Proteomes; UP000034805; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000034805}; KW Reference proteome {ECO:0000313|Proteomes:UP000034805}. FT DOMAIN 13 166 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 169 169 {ECO:0000313|EMBL:KPP56329.1}. SQ SEQUENCE 169 AA; 20501 MW; F8DAFDF66B3DC153 CRC64; MRATLIYGET PFPEFSLVVL VNDVPVEYYD SDIKKFVSRR HWRVNDTIEE FRFRNFMVEE IYNAMKVPSL FLRRHFNHTE GLHIYQGVAA CDLEDNKVNR FFITSAYDRE EKYQYDVLTQ AQNTLGPEFV WNKIFMEAKK LRCSYVYKPL FEEILRRYLQ EDKNILLRK // ID A0A0N8JUV6_9TELE Unreviewed; 105 AA. AC A0A0N8JUV6; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 25-OCT-2017, entry version 6. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KPP56401.1}; DE Flags: Fragment; GN ORFNames=Z043_125984 {ECO:0000313|EMBL:KPP56401.1}; OS Scleropages formosus (Asian bonytongue). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala; OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages. OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP56401.1, ECO:0000313|Proteomes:UP000034805}; RN [1] {ECO:0000313|EMBL:KPP56401.1, ECO:0000313|Proteomes:UP000034805} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP56401.1}; RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.; RT "The genome of the Asian arowana (Scleropages formosus)."; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KPP56401.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JARO02021578; KPP56401.1; -; Genomic_DNA. DR Proteomes; UP000034805; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000034805}; KW Reference proteome {ECO:0000313|Proteomes:UP000034805}. FT DOMAIN 2 89 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:KPP56401.1}. SQ SEQUENCE 105 AA; 12315 MW; 0EAC96F59F64A4B4 CRC64; IHIVQQMYGC EWDDDTGTTR AHRQDGYDGE DFITLDFKTM SYVAPVPQAV PTKDKWNNDK AFIENDRNYF SQICIEWLKK YVDYGKETLQ RKGTVQLPRY RGSPA // ID A0A0N8JVG3_9TELE Unreviewed; 249 AA. AC A0A0N8JVG3; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 25-OCT-2017, entry version 9. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KPP58057.1}; GN ORFNames=Z043_124155 {ECO:0000313|EMBL:KPP58057.1}; OS Scleropages formosus (Asian bonytongue). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala; OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages. OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP58057.1, ECO:0000313|Proteomes:UP000034805}; RN [1] {ECO:0000313|EMBL:KPP58057.1, ECO:0000313|Proteomes:UP000034805} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP58057.1}; RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.; RT "The genome of the Asian arowana (Scleropages formosus)."; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KPP58057.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JARO02014781; KPP58057.1; -; Genomic_DNA. DR Proteomes; UP000034805; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000034805}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000034805}. FT DOMAIN 110 211 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT UNSURE 12 12 I or L. {ECO:0000313|EMBL:KPP58057.1}. SQ SEQUENCE 249 AA; 28841 MW; 4B314088BABCE6E5 CRC64; MIRLFXLFFS DLHVLQWRHG CKGVLQPDGS LKFLMGFDLY SYDGEDFLSF NEPESQWIAP VQAAVQTKKK WDESQTLNQY TKGYLQKECM DWLSKFMNYG EAELRKHSPP EVFAFAKKGK NPENVVLHCL ATGFYPKDVE LVIYRKGVPL SETDGVVSTG VRPNGVRPER VNPDERPGET FQLRKFIEVS KSDNSEYSCE VKHRTLEAPI IIKWGTAYIF TLKLCFECNE HDEIVCIRLQ QISCQQERN // ID A0A0P7UC03_9TELE Unreviewed; 65 AA. AC A0A0P7UC03; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 25-OCT-2017, entry version 6. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KPP56102.1}; DE Flags: Fragment; GN ORFNames=Z043_126354 {ECO:0000313|EMBL:KPP56102.1}; OS Scleropages formosus (Asian bonytongue). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala; OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages. OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP56102.1, ECO:0000313|Proteomes:UP000034805}; RN [1] {ECO:0000313|EMBL:KPP56102.1, ECO:0000313|Proteomes:UP000034805} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP56102.1}; RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.; RT "The genome of the Asian arowana (Scleropages formosus)."; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KPP56102.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JARO02032352; KPP56102.1; -; Genomic_DNA. DR Proteomes; UP000034805; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000034805}; KW Reference proteome {ECO:0000313|Proteomes:UP000034805}. FT DOMAIN 1 63 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 65 65 {ECO:0000313|EMBL:KPP56102.1}. SQ SEQUENCE 65 AA; 7671 MW; 5C687BF3DF76113C CRC64; MGLVDGEQID YYDSNIRRTI PRVEWMEKSM GPDYWDRQTQ VSIGEEQNFK NNIEVAKKRF NQTGG // ID A0A0P7W4M9_9TELE Unreviewed; 142 AA. AC A0A0P7W4M9; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 28-MAR-2018, entry version 11. DE SubName: Full=MHC class I antigen-like {ECO:0000313|EMBL:KPP57443.1}; DE Flags: Fragment; GN ORFNames=Z043_124835 {ECO:0000313|EMBL:KPP57443.1}; OS Scleropages formosus (Asian bonytongue). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala; OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages. OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP57443.1, ECO:0000313|Proteomes:UP000034805}; RN [1] {ECO:0000313|EMBL:KPP57443.1, ECO:0000313|Proteomes:UP000034805} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP57443.1}; RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.; RT "The genome of the Asian arowana (Scleropages formosus)."; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KPP57443.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JARO02016431; KPP57443.1; -; Genomic_DNA. DR Proteomes; UP000034805; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000034805}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000034805}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 6 28 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 35 121 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:KPP57443.1}. FT NON_TER 142 142 {ECO:0000313|EMBL:KPP57443.1}. SQ SEQUENCE 142 AA; 16344 MW; B9B7639132274DCE CRC64; PGINLLPIII DYVAALLVVA AGAGFLVWRN KKKVTHSLNY VYTGTSGIPD LPDFVSVGLL NGEPIDYYDS NIHKAVLRQD WMAKIEESDY WEMQNNILNN HKHWFKNSIK ILKDRFNQTE DAHEQYGYNG NDFISLDLKT MR // ID A0A0P7WCV4_9TELE Unreviewed; 316 AA. AC A0A0P7WCV4; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 25-OCT-2017, entry version 8. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KPP59030.1}; DE Flags: Fragment; GN ORFNames=Z043_123093 {ECO:0000313|EMBL:KPP59030.1}; OS Scleropages formosus (Asian bonytongue). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala; OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages. OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP59030.1, ECO:0000313|Proteomes:UP000034805}; RN [1] {ECO:0000313|EMBL:KPP59030.1, ECO:0000313|Proteomes:UP000034805} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP59030.1}; RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.; RT "The genome of the Asian arowana (Scleropages formosus)."; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KPP59030.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JARO02012810; KPP59030.1; -; Genomic_DNA. DR Proteomes; UP000034805; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 2. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 2. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000034805}; KW Reference proteome {ECO:0000313|Proteomes:UP000034805}. FT DOMAIN 51 158 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 225 310 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 316 316 {ECO:0000313|EMBL:KPP59030.1}. SQ SEQUENCE 316 AA; 36195 MW; 75B7DE60FF7767B6 CRC64; MGILDDKEXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XSINILMDRM RHNNSDVHVL QCRIGCRGVH QPDGSLRFLG STYSYGYDGE DFLSFDDSNS QWIASVPAAL PTKRKRDKSQ ILNQYTKGYL QKECMDCLSK FMYYGEADLR KHSPPQVFLY ARKSKISGKV FLHCLATGLH LKDVKLDLYR NGVVMTESDG LMSTGIRPNG LNPDQWRHGC KGVQQPDGSL KFKEGFDQYS YDGEDFLSFD ESNSRWIAPV PAAQPTKKKW DDSQTLNQYT KGYLQKECMD WLSKFMYYGE VDLRKH // ID A0A0P7YAX9_9TELE Unreviewed; 217 AA. AC A0A0P7YAX9; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 25-OCT-2017, entry version 8. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KPP63290.1}; GN ORFNames=Z043_118465 {ECO:0000313|EMBL:KPP63290.1}; OS Scleropages formosus (Asian bonytongue). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala; OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages. OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP63290.1, ECO:0000313|Proteomes:UP000034805}; RN [1] {ECO:0000313|EMBL:KPP63290.1, ECO:0000313|Proteomes:UP000034805} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP63290.1}; RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.; RT "The genome of the Asian arowana (Scleropages formosus)."; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KPP63290.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JARO02008008; KPP63290.1; -; Genomic_DNA. DR Proteomes; UP000034805; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000034805}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000034805}. FT DOMAIN 98 189 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 217 AA; 25333 MW; 5DB046667C02DC75 CRC64; MHSSPAGVHV YQKFAACDLE GDSLTRFFLQ DAYEGVETRN YDILTQAYSP LVPELIWTKV QMETKKLTYI NVYQPLCLRT LRRYLQENKN ILLRKVRPRV RVMRKANVAS GKMNIVCLAT GFYPRHIKMT LLRDERAVPD EELTAGEVFP NGDGTYQLRR SLALSEEEQR KKHVYTCTVT HLSLDNKLDV RWGMTHVECV QSKRVERCCF IWYVAPR // ID A0A0R4IIT0_DANRE Unreviewed; 331 AA. AC A0A0R4IIT0; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 12-SEP-2018, entry version 26. DE SubName: Full=Major histocompatibility complex class I ZAA {ECO:0000313|Ensembl:ENSDARP00000133701}; GN Name=mhc1zaa {ECO:0000313|Ensembl:ENSDARP00000133701}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000133701, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000133701, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000133701, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [2] {ECO:0000313|Ensembl:ENSDARP00000133701} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000133701}; RG Ensembl; RL Submitted (NOV-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CU394254; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSDART00000161964; ENSDARP00000133701; ENSDARG00000092162. DR ZFIN; ZDB-GENE-030916-1; mhc1zaa. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000000437; Chromosome 3. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A0R4IIT0}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 331 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015362682. FT DOMAIN 218 305 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 331 AA; 38795 MW; 1C6CA2A3D1C5DC7A CRC64; MMSGGVASGI CALLCVFLLC GDLPSAQGEK HSLYYIYTSL SKPLDLPGIY EFSAMGLLDD RQIDSYNSEE QRKIPKQQWM KEKMQEDYWE KGTWSRKSKE QWFNVNVHIL MERMRHNMSD LHILQWRHGC EVEIQGSEVK FSKGVSEYGY DGENLLYFDD AESRWVAPVE EALPTKRKWD NIPILNQYTK GYLEKECVDW LNKFREYADE ELRKASSPDV YKLTKKSTKD ETKLKLTCLA TGFYDKDVML NIRRNCLPED ETESTGVRPN HDQTFQLRKS VEIKEDQIDE YDCHLTHRTL KNPVTATRAK QRGIESWNLF FTYGALHIWC C // ID A0A0R4IZK4_DANRE Unreviewed; 350 AA. AC A0A0R4IZK4; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 12-SEP-2018, entry version 23. DE SubName: Full=Si:dkey-225f5.5 {ECO:0000313|Ensembl:ENSDARP00000141825}; GN Name=si:dkey-225f5.5 {ECO:0000313|Ensembl:ENSDARP00000141825, GN ECO:0000313|ZFIN:ZDB-GENE-141216-18}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000141825, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000141825, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000141825, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [2] {ECO:0000313|Ensembl:ENSDARP00000141825} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000141825}; RG Ensembl; RL Submitted (NOV-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX682558; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_001340413.4; XM_001340377.6. DR ProteinModelPortal; A0A0R4IZK4; -. DR PaxDb; A0A0R4IZK4; -. DR Ensembl; ENSDART00000161672; ENSDARP00000141825; ENSDARG00000055813. DR GeneID; 100000140; -. DR KEGG; dre:100000140; -. DR ZFIN; ZDB-GENE-141216-18; si:dkey-225f5.5. DR GeneTree; ENSGT00740000114936; -. DR PhylomeDB; A0A0R4IZK4; -. DR Reactome; R-DRE-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000000437; Chromosome 3. DR ExpressionAtlas; A0A0R4IZK4; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 350 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5006451907. FT TRANSMEM 302 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 350 AA; 40065 MW; D9DBB0521C92CB0E CRC64; MMYLVLAVCI LSASVFSQSG SHSLWVFATF LTGDISVQFP EFSAVVMLDD IVIGHYNADD RSFVPSTVQE SVNITEQITI STVCKGIHEG MKTKAYYLID YLNHTRGLHV QQRLVGCELL QNEPGQMMTL EAFNGESGFE RRYDIQGDQQ THWKWPVIKS RAQLEYDAWL YAHFYRPLCI SQLRKYLKKE KKRVMARVKP RVRVIQRTCS KTGKIQMTCL ATGFYPRHIN LTLLQDGQPV NEERVMGGEL LPNADGTYQM RKSVELSAEE QRERRTYTCT VNHLSLDNKL DISIEPGLDP VIIFPSVLLL LCVFGVLAGF LMWRKKYKQP EQVTYTPTSA TDQTTEQSQL // ID A0A140T8W8_HUMAN Unreviewed; 299 AA. AC A0A140T8W8; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 12. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000366018}; GN Name=HLA-A {ECO:0000313|Ensembl:ENSP00000366018}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000366018}; RN [1] {ECO:0000313|Ensembl:ENSP00000366018, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] {ECO:0000313|Ensembl:ENSP00000366018} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL845454; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T8W8; -. DR PRIDE; A0A140T8W8; -. DR Ensembl; ENST00000376822; ENSP00000366018; ENSG00000206505. DR HGNC; HGNC:4931; HLA-A. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Proteomics identification {ECO:0000213|EPD:A0A140T8W8, KW ECO:0000213|MaxQB:A0A140T8W8, ECO:0000213|PeptideAtlas:A0A140T8W8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 299 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305387. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 299 AA; 34426 MW; 4F0AB6BAAF4AC89F CRC64; MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WETAHEAEQW RAYLEGRCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWV // ID A0A140T8X0_HUMAN Unreviewed; 334 AA. AC A0A140T8X0; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000366040}; DE Flags: Fragment; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000366040}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000366040}; RN [1] {ECO:0000313|Ensembl:ENSP00000366040, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000366040} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759790; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T8X0; -. DR PRIDE; A0A140T8X0; -. DR Ensembl; ENST00000376844; ENSP00000366040; ENSG00000234487. DR HGNC; HGNC:4963; HLA-F. DR PhylomeDB; A0A140T8X0; -. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T8X0, KW ECO:0000213|PeptideAtlas:A0A140T8X0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 334 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305344. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 284 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 334 334 {ECO:0000313|Ensembl:ENSP00000366040}. SQ SEQUENCE 334 AA; 37746 MW; 1EB256D61029A1F7 CRC64; MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL QRADPPKAHV AHHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPQP LILRWEQSPQ PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSS // ID A0A140T8Y4_HUMAN Unreviewed; 371 AA. AC A0A140T8Y4; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000373114}; GN Name=HLA-A {ECO:0000313|Ensembl:ENSP00000373114}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000373114}; RN [1] {ECO:0000313|Ensembl:ENSP00000373114, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] {ECO:0000313|Ensembl:ENSP00000373114} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL845454; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000383619; ENSP00000373114; ENSG00000206505. DR HGNC; HGNC:4931; HLA-A. DR PhylomeDB; A0A140T8Y4; -. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A140T8Y4, KW ECO:0000213|MaxQB:A0A140T8Y4, ECO:0000213|PeptideAtlas:A0A140T8Y4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 371 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305488. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 371 AA; 41621 MW; DFB7CCF1CBF90000 CRC64; MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WETAHEAEQW RAYLEGRCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV MWRRKSSGGE GMKDRKGGSY SQAASSDSAQ GSDMSLTACK V // ID A0A140T908_HUMAN Unreviewed; 131 AA. AC A0A140T908; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000388133}; DE Flags: Fragment; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000388133}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000388133}; RN [1] {ECO:0000313|Ensembl:ENSP00000388133, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000388133} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR753818; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T908; -. DR Ensembl; ENST00000447400; ENSP00000388133; ENSG00000235220. DR HGNC; HGNC:4963; HLA-F. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T908, KW ECO:0000213|PeptideAtlas:A0A140T908}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 131 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305348. FT DOMAIN 22 130 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 131 131 {ECO:0000313|Ensembl:ENSP00000388133}. SQ SEQUENCE 131 AA; 14764 MW; B7675BCAC46149C7 CRC64; MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL L // ID A0A140T912_HUMAN Unreviewed; 372 AA. AC A0A140T912; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000388708}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000388708}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000388708}; RN [1] {ECO:0000313|Ensembl:ENSP00000388708, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [3] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [4] {ECO:0000313|Ensembl:ENSP00000388708} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX927178; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T912; -. DR PRIDE; A0A140T912; -. DR Ensembl; ENST00000453809; ENSP00000388708; ENSG00000237022. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A140T912, KW ECO:0000213|MaxQB:A0A140T912, ECO:0000213|PeptideAtlas:A0A140T912}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 372 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305562. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 372 AA; 41466 MW; A4E4A1AC1EC0795A CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEAGSHTLQ WMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARAAEQQ RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHLVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGH FLPTGGKGGS CSQAASSNSA QGSDESLIAC KA // ID A0A140T913_HUMAN Unreviewed; 371 AA. AC A0A140T913; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 14. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000388526}; GN Name=HLA-A {ECO:0000313|Ensembl:ENSP00000388526}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000388526}; RN [1] {ECO:0000313|Ensembl:ENSP00000388526, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:18088087} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18088087; DOI=10.1021/pr0704130; RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., RA Schutz C., Walter U., Gambaryan S., Sickmann A.; RT "Phosphoproteome of resting human platelets."; RL J. Proteome Res. 7:526-534(2008). RN [3] {ECO:0000213|PubMed:19413330} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., RA Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in RT a refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [4] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] {ECO:0000213|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [6] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [7] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [8] {ECO:0000313|Ensembl:ENSP00000388526} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR388205; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR388220; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T913; -. DR PRIDE; A0A140T913; -. DR Ensembl; ENST00000438861; ENSP00000388526; ENSG00000235657. DR HGNC; HGNC:4931; HLA-A. DR PhylomeDB; A0A140T913; -. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A140T913, KW ECO:0000213|MaxQB:A0A140T913, ECO:0000213|PeptideAtlas:A0A140T913}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 371 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305403. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 371 AA; 41449 MW; 090C47ADC3329740 CRC64; MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDGETRK VKAHSQTHRV DLGTLRGYYN QSEAGSHTVQ RMYGCDVGSD WRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQTTKHK WEAAHVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSGGE GVKDRKGGSY SQAASSDSAQ GSDVSLTACK V // ID A0A140T921_HUMAN Unreviewed; 368 AA. AC A0A140T921; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000389248}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000389248}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000389248}; RN [1] {ECO:0000313|Ensembl:ENSP00000389248, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000389248} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL662833; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T921; -. DR PRIDE; A0A140T921; -. DR Ensembl; ENST00000422726; ENSP00000389248; ENSG00000233841. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:A0A140T921, KW ECO:0000213|MaxQB:A0A140T921, ECO:0000213|PeptideAtlas:A0A140T921}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 368 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305565. FT TRANSMEM 306 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 41206 MW; A236211600DC91FE CRC64; MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSAA CVGLRCRISS HLSFVTSRAS GISFCKGV // ID A0A140T925_HUMAN Unreviewed; 131 AA. AC A0A140T925; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000389555}; DE Flags: Fragment; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000389555}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000389555}; RN [1] {ECO:0000313|Ensembl:ENSP00000389555, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000389555} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX005428; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000444057; ENSP00000389555; ENSG00000229698. DR HGNC; HGNC:4963; HLA-F. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T925, KW ECO:0000213|PeptideAtlas:A0A140T925}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 131 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305353. FT DOMAIN 22 130 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 131 131 {ECO:0000313|Ensembl:ENSP00000389555}. SQ SEQUENCE 131 AA; 14764 MW; B7675BCAC46149C7 CRC64; MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL L // ID A0A140T930_HUMAN Unreviewed; 397 AA. AC A0A140T930; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 14. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000390282}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000390282}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000390282}; RN [1] {ECO:0000313|Ensembl:ENSP00000390282, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000390282} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX927178; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T930; -. DR Ensembl; ENST00000414249; ENSP00000390282; ENSG00000237022. DR HGNC; HGNC:4933; HLA-C. DR PhylomeDB; A0A140T930; -. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:A0A140T930, KW ECO:0000213|MaxQB:A0A140T930, ECO:0000213|PeptideAtlas:A0A140T930}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 397 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305567. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 397 AA; 44433 MW; A8229D0A6BA701EC CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEAGSHTLQ WMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARAAEQQ RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHLVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGR EGVRSGVWPA TVPRALMSLS SLVKPETAAC VGLRCRISSH LSFVTSRASG ISFCKGI // ID A0A140T933_HUMAN Unreviewed; 299 AA. AC A0A140T933; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000390225}; DE Flags: Fragment; GN Name=HLA-A {ECO:0000313|Ensembl:ENSP00000390225}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000390225}; RN [1] {ECO:0000313|Ensembl:ENSP00000390225, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] {ECO:0000313|Ensembl:ENSP00000390225} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759762; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T933; -. DR PRIDE; A0A140T933; -. DR Ensembl; ENST00000413609; ENSP00000390225; ENSG00000227715. DR HGNC; HGNC:4931; HLA-A. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140T933, KW ECO:0000213|MaxQB:A0A140T933, ECO:0000213|PeptideAtlas:A0A140T933}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 299 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305408. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000390225}. SQ SEQUENCE 299 AA; 34268 MW; D464FBFDA50FCECE CRC64; XAVMAPRTLV LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDGETRK VKAHSQTHRV DLGTLRGYYN QSEAGSHTVQ RMYGCDVGSD WRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQTTKHK WEAAHVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWV // ID A0A140T937_HUMAN Unreviewed; 339 AA. AC A0A140T937; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000390860}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000390860}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000390860}; RN [1] {ECO:0000313|Ensembl:ENSP00000390860, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000390860} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX927178; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T937; -. DR Ensembl; ENST00000419590; ENSP00000390860; ENSG00000237022. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:A0A140T937, KW ECO:0000213|MaxQB:A0A140T937, ECO:0000213|PeptideAtlas:A0A140T937}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 339 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305435. FT TRANSMEM 308 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 339 AA; 38331 MW; 496E69C4405B9E8F CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEAGSHTLQ WMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARAAEQQ RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHLVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSA // ID A0A140T939_HUMAN Unreviewed; 225 AA. AC A0A140T939; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 12. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000390887}; DE Flags: Fragment; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000390887}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000390887}; RN [1] {ECO:0000313|Ensembl:ENSP00000390887, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000390887} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX005428; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T939; -. DR Ensembl; ENST00000454779; ENSP00000390887; ENSG00000229698. DR HGNC; HGNC:4963; HLA-F. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T939, KW ECO:0000213|PeptideAtlas:A0A140T939}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 184 208 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 85 163 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000390887}. SQ SEQUENCE 225 AA; 25193 MW; AEBB12BB0D28F65F CRC64; XPDPPPGRVP GAFTQHAYDG KDYISLNEDL RSWTAADTVA QITQRFYEAE EYAEEFRTYL EGECLELLRR YLENGKETLQ RADPPKAHVA HHPISDHEAT LRCWALGFYP AEITLTWQRD GEEQTQDTEL VETRPAGDGT FQKWAAVVVP SGEEQRYTCH VQHEGLPQPL ILRWEQSPQP TIPIVGIVAG LVVLGAVVTG AVVAAVMWRK KSSDRNRGSY SQAAV // ID A0A140T941_HUMAN Unreviewed; 299 AA. AC A0A140T941; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 12. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000391738}; GN Name=HLA-A {ECO:0000313|Ensembl:ENSP00000391738}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000391738}; RN [1] {ECO:0000313|Ensembl:ENSP00000391738, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] {ECO:0000313|Ensembl:ENSP00000391738} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR382333; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T941; -. DR PRIDE; A0A140T941; -. DR Ensembl; ENST00000450342; ENSP00000391738; ENSG00000231834. DR HGNC; HGNC:4931; HLA-A. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Proteomics identification {ECO:0000213|EPD:A0A140T941, KW ECO:0000213|MaxQB:A0A140T941, ECO:0000213|PeptideAtlas:A0A140T941}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 299 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305570. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 299 AA; 34146 MW; 746200101E76ECA2 CRC64; MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDLQTRN VKAQSQTDRA NLGTLRGYYN QSEAGSHTIQ MMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWV // ID A0A140T942_HUMAN Unreviewed; 261 AA. AC A0A140T942; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000391250}; DE Flags: Fragment; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000391250}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000391250}; RN [1] {ECO:0000313|Ensembl:ENSP00000391250, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000391250} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR388229; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T942; -. DR PRIDE; A0A140T942; -. DR Ensembl; ENST00000454033; ENSP00000391250; ENSG00000228299. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140T942, KW ECO:0000213|MaxQB:A0A140T942, ECO:0000213|PeptideAtlas:A0A140T942}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 261 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305414. FT DOMAIN 26 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000391250}. FT NON_TER 261 261 {ECO:0000313|Ensembl:ENSP00000391250}. SQ SEQUENCE 261 AA; 29961 MW; 16F24D1B5A8F41DE CRC64; XRVMAPRTLI LLLSGALALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV NLRKLRGYYN QSEDGSHTLQ WMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQW RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHPVSD HEASRRWNLP EVGSCGGAFW RRAEIHVPCA ARGAARAPHP E // ID A0A140T951_HUMAN Unreviewed; 241 AA. AC A0A140T951; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 14. DE SubName: Full=HLA class I histocompatibility antigen, B-46 alpha chain {ECO:0000313|Ensembl:ENSP00000392099}; DE Flags: Fragment; GN Name=HLA-B {ECO:0000313|Ensembl:ENSP00000392099}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000392099}; RN [1] {ECO:0000313|Ensembl:ENSP00000392099, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [4] {ECO:0000313|Ensembl:ENSP00000392099} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL662833; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL669854; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL845556; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T951; -. DR PRIDE; A0A140T951; -. DR Ensembl; ENST00000416726; ENSP00000392099; ENSG00000223532. DR HGNC; HGNC:4932; HLA-B. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A140T951, KW ECO:0000213|MaxQB:A0A140T951, ECO:0000213|PeptideAtlas:A0A140T951}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 181 205 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 82 168 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000392099}. SQ SEQUENCE 241 AA; 26539 MW; 5805EC9BE6278242 CRC64; XPDGRLLRGH NQYAYDGKDY IALNEDLRSW TAADTAAQIT QRKWEAARVA EQDRAYLEGT CVEWLRRYLE NGKDTLERAD PPKTHVTHHP ISDHEATLRC WALGFYPAEI TLTWQRDGED QTQDTELVET RPAGDRTFQK WAAVVVPSGE EQRYTCHVQH EGLPKPLTLR WEPSSQSTVP IVGIVAGLAV LAVVVIGAVV AAVMCRRKSS GHFLPTGGKG GSYSQAACSD SAQGSDVSLT A // ID A0A140T953_HUMAN Unreviewed; 246 AA. AC A0A140T953; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, B-46 alpha chain {ECO:0000313|Ensembl:ENSP00000392235}; DE Flags: Fragment; GN Name=HLA-B {ECO:0000313|Ensembl:ENSP00000392235}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000392235}; RN [1] {ECO:0000313|Ensembl:ENSP00000392235, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [3] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [4] {ECO:0000313|Ensembl:ENSP00000392235} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759828; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T953; -. DR PRIDE; A0A140T953; -. DR Ensembl; ENST00000437866; ENSP00000392235; ENSG00000232126. DR HGNC; HGNC:4932; HLA-B. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140T953, KW ECO:0000213|MaxQB:A0A140T953, ECO:0000213|PeptideAtlas:A0A140T953}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 36 214 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 246 246 {ECO:0000313|Ensembl:ENSP00000392235}. SQ SEQUENCE 246 AA; 27677 MW; DA4060CFFCC44615 CRC64; MASVGRSEGT AGGGAGPGEP RREEGRAGLS PSSPPGSHSM RYFYTAMSRP GRGEPRFIAV GYVDDTQFVR FDSDAASPRM APRAPWIEQE GPEYWDRETQ ISKTNTQTYR ESLRNLRGYY NQSEAGSHTL QRMYGCDVGP DGRLLRGHDQ SAYDGKDYIA LNEDLSSWTA ADTAAQITQR KWEAAREAEQ WRAYLEGLCV EWLRRYLENG KETLQRADPP KTHVTHHPIS DHEATLRCWA LGFYPA // ID A0A140T955_HUMAN Unreviewed; 299 AA. AC A0A140T955; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000392547}; GN Name=HLA-A {ECO:0000313|Ensembl:ENSP00000392547}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000392547}; RN [1] {ECO:0000313|Ensembl:ENSP00000392547, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] {ECO:0000313|Ensembl:ENSP00000392547} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR388205; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR388220; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T955; -. DR Ensembl; ENST00000453975; ENSP00000392547; ENSG00000235657. DR HGNC; HGNC:4931; HLA-A. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Proteomics identification {ECO:0000213|EPD:A0A140T955, KW ECO:0000213|MaxQB:A0A140T955, ECO:0000213|PeptideAtlas:A0A140T955}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 299 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305417. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 299 AA; 34288 MW; D46B5AE8A50BD07E CRC64; MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDGETRK VKAHSQTHRV DLGTLRGYYN QSEAGSHTVQ RMYGCDVGSD WRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQTTKHK WEAAHVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWV // ID A0A140T962_HUMAN Unreviewed; 368 AA. AC A0A140T962; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 14. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000393458}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000393458}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000393458}; RN [1] {ECO:0000313|Ensembl:ENSP00000393458, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000393458} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR388229; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EPD; A0A140T962; -. DR PeptideAtlas; A0A140T962; -. DR PRIDE; A0A140T962; -. DR Ensembl; ENST00000456487; ENSP00000393458; ENSG00000228299. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:A0A140T962, KW ECO:0000213|MaxQB:A0A140T962, ECO:0000213|PeptideAtlas:A0A140T962}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 368 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305575. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 41525 MW; FCF242B3749469DF CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV NLRKLRGYYN QSEDGSHTLQ WMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQW RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVMAV VMCRRKSSAA CVGLRCRISS HLSFVTSRAS GISFCKGI // ID A0A140T975_HUMAN Unreviewed; 299 AA. AC A0A140T975; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000394582}; GN Name=HLA-A {ECO:0000313|Ensembl:ENSP00000394582}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000394582}; RN [1] {ECO:0000313|Ensembl:ENSP00000394582, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] {ECO:0000313|Ensembl:ENSP00000394582} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX005091; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX088647; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX120004; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T975; -. DR PRIDE; A0A140T975; -. DR Ensembl; ENST00000414592; ENSP00000394582; ENSG00000223980. DR HGNC; HGNC:4931; HLA-A. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Proteomics identification {ECO:0000213|EPD:A0A140T975, KW ECO:0000213|MaxQB:A0A140T975, ECO:0000213|PeptideAtlas:A0A140T975}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 299 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305576. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 299 AA; 34321 MW; 197B0AA6CCE07863 CRC64; MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAHSQTDRE SLRIALRYYN QSEAGSHTIQ MMYGCDVGPD GRLLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWV // ID A0A140T979_HUMAN Unreviewed; 360 AA. AC A0A140T979; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=MHC class I polypeptide-related sequence B {ECO:0000313|Ensembl:ENSP00000394437}; DE Flags: Fragment; GN Name=MICB {ECO:0000313|Ensembl:ENSP00000394437}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000394437}; RN [1] {ECO:0000313|Ensembl:ENSP00000394437, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000394437} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX927320; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T979; -. DR Ensembl; ENST00000428059; ENSP00000394437; ENSG00000231372. DR HGNC; HGNC:7091; MICB. DR PhylomeDB; A0A140T979; -. DR ChiTaRS; MICB; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T979, KW ECO:0000213|PeptideAtlas:A0A140T979}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 184 279 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000394437}. SQ SEQUENCE 360 AA; 40245 MW; FE19C034A1B49349 CRC64; XPHSLRYNLM VLSQDGSVQS GFLAEGHLDG QPFLRYDRQK RRAKPQGQWA EDVLGAKTWD TETEDLTENG QDLRRTLTHI KDQKGGLHSL QEIRVCEIHE DSSTRGSRHF YYDGELFLSQ NLETQESTVP QSSRAQTLAM NVTNFWKEDA MKTKTHYRAM QADCLQKLQR YLKSGVAIRR TVPPMVNVTC SEVSEGNITV TCRASSFYPR NITLTWRQDG VSLSHNTQQW GDVLPDGNGT YQTWVATRIR QGEEQRFTCY MEHSGNHGTH PVPSGKALVL QSQRTDFPYV SAAMPCFVII IILCVPCCKK KTSAAEGPEL VSLQVLDQHP VGTGDHRDAA QLGFQPLMSA TGSTGSTEGA // ID A0A140T986_HUMAN Unreviewed; 342 AA. AC A0A140T986; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 12. DE SubName: Full=MHC class I polypeptide-related sequence A {ECO:0000313|Ensembl:ENSP00000395645}; GN Name=MICA {ECO:0000313|Ensembl:ENSP00000395645}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000395645}; RN [1] {ECO:0000313|Ensembl:ENSP00000395645, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000395645} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR318637; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR847852; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000432479; ENSP00000395645; ENSG00000235233. DR HGNC; HGNC:7090; MICA. DR ChiTaRS; MICA; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T986, KW ECO:0000213|PeptideAtlas:A0A140T986}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 342 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305514. FT TRANSMEM 267 287 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 164 253 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 342 AA; 37988 MW; EA740EF7A2F70B19 CRC64; MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLAEVH LDGQPFLRYD RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL AHIKDQKEVP QSSRAQTLAM NVRNFLKEDA MKTKTHYHAM HADCLQELRR YLESSVVLRR RVPPMVNVTR SEASEGNITV TCRASSFYPR NITLTWRQDG VSLSHDTQQW GDVLPDGNGT YQTWVATRIC QGEEQRFTCY MEHSGNHSTH PVPSGKVLVL QSHWQTFHVS AVAAAAAAIF VIIIFYVRCC KKKTSAAEGP ELVSLQVLDQ HPVGTSDHRD ATQLGFQPLM SALGSTGSTE GA // ID A0A140T997_HUMAN Unreviewed; 246 AA. AC A0A140T997; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, B-46 alpha chain {ECO:0000313|Ensembl:ENSP00000396397}; DE Flags: Fragment; GN Name=HLA-B {ECO:0000313|Ensembl:ENSP00000396397}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000396397}; RN [1] {ECO:0000313|Ensembl:ENSP00000396397, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] {ECO:0000313|Ensembl:ENSP00000396397} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX248310; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T997; -. DR PRIDE; A0A140T997; -. DR Ensembl; ENST00000445610; ENSP00000396397; ENSG00000228964. DR HGNC; HGNC:4932; HLA-B. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140T997, KW ECO:0000213|MaxQB:A0A140T997, ECO:0000213|PeptideAtlas:A0A140T997}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 36 214 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 246 246 {ECO:0000313|Ensembl:ENSP00000396397}. SQ SEQUENCE 246 AA; 27769 MW; 27C430B8A7BD4725 CRC64; MASVGRREGT AGGGAGPGEP RREEGRAGLS PSSPPGSHSM RYFYTAMSRP GRGEPRFITV GYVDDTLFVR FDSDATSPRK EPRAPWIEQE GPEYWDRETQ ISKTNTQTYR ENLRTALRYY NQSEAGSHII QRMYGCDVGP DGRLLRGYDQ DAYDGKDYIA LNEDLSSWTA ADTAAQITQR KWEAARVAEQ DRAYLEGLCV ESLRRYLENG KETLQRADPP KTHVTHHPIS DHEVTLRCWA LGFYPA // ID A0A140T9A3_HUMAN Unreviewed; 131 AA. AC A0A140T9A3; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000396776}; DE Flags: Fragment; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000396776}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000396776}; RN [1] {ECO:0000313|Ensembl:ENSP00000396776, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000396776} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX927250; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000437020; ENSP00000396776; ENSG00000237508. DR HGNC; HGNC:4963; HLA-F. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9A3, KW ECO:0000213|PeptideAtlas:A0A140T9A3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 131 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305516. FT DOMAIN 22 130 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 131 131 {ECO:0000313|Ensembl:ENSP00000396776}. SQ SEQUENCE 131 AA; 14764 MW; B7675BCAC46149C7 CRC64; MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL L // ID A0A140T9A9_HUMAN Unreviewed; 241 AA. AC A0A140T9A9; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, B-46 alpha chain {ECO:0000313|Ensembl:ENSP00000398100}; DE Flags: Fragment; GN Name=HLA-B {ECO:0000313|Ensembl:ENSP00000398100}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000398100}; RN [1] {ECO:0000313|Ensembl:ENSP00000398100, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [4] {ECO:0000313|Ensembl:ENSP00000398100} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX248310; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9A9; -. DR PRIDE; A0A140T9A9; -. DR Ensembl; ENST00000437265; ENSP00000398100; ENSG00000228964. DR HGNC; HGNC:4932; HLA-B. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9A9, KW ECO:0000213|MaxQB:A0A140T9A9, ECO:0000213|PeptideAtlas:A0A140T9A9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 181 205 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 82 168 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000398100}. SQ SEQUENCE 241 AA; 26403 MW; 435D5BF756C55211 CRC64; XPDGRLLRGY DQDAYDGKDY IALNEDLSSW TAADTAAQIT QRKWEAARVA EQDRAYLEGL CVESLRRYLE NGKETLQRAD PPKTHVTHHP ISDHEVTLRC WALGFYPAEI TLTWQRDGED QTQDTELVET RPAGDRTFQK WAAVVVPSGE EQRYTCHVQH EGLPKPLTLR WEPSSQSTVP IVGIVAGLAV LAVVVIGAVV AAVMCRRKSS GHFLPTGGKG GSYSQAACSD SAQGSDVSLT A // ID A0A140T9B3_HUMAN Unreviewed; 397 AA. AC A0A140T9B3; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 15. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000397867}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000397867}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000397867}; RN [1] {ECO:0000313|Ensembl:ENSP00000397867, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000397867} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR388229; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EPD; A0A140T9B3; -. DR Ensembl; ENST00000422921; ENSP00000397867; ENSG00000228299. DR HGNC; HGNC:4933; HLA-C. DR PhylomeDB; A0A140T9B3; -. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9B3, KW ECO:0000213|MaxQB:A0A140T9B3, ECO:0000213|PeptideAtlas:A0A140T9B3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 397 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305424. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 397 AA; 44588 MW; 5C6E83DD9A5C4242 CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV NLRKLRGYYN QSEDGSHTLQ WMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQW RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVMAV VMCRRKSSGR EGVRSGVWPA TVPRALMSLS SLVKPETAAC VGLRCRISSH LSFVTSRASG ISFCKGI // ID A0A140T9B7_HUMAN Unreviewed; 442 AA. AC A0A140T9B7; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 14. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000397705}; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000397705}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000397705}; RN [1] {ECO:0000313|Ensembl:ENSP00000397705, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000397705} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX005428; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9B7; -. DR Ensembl; ENST00000430472; ENSP00000397705; ENSG00000229698. DR HGNC; HGNC:4963; HLA-F. DR PhylomeDB; A0A140T9B7; -. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9B7, KW ECO:0000213|PeptideAtlas:A0A140T9B7}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 442 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305453. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 349 370 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 390 412 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 284 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 442 AA; 50427 MW; 6459D3E5F4B5704A CRC64; MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL QRADPPKAHV AHHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPQP LILRWEQSPQ PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAAYSVV SGLLMITWWS SLFLLGVLFQ GYLGCLRSHS VLGRRKVGDM WILFFLWLWT SFNTAFLALQ SLRFGFGFRR GRSFLLRSWH HLMKRVQIKI FD // ID A0A140T9B8_HUMAN Unreviewed; 276 AA. AC A0A140T9B8; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 12. DE SubName: Full=MHC class I polypeptide-related sequence A {ECO:0000313|Ensembl:ENSP00000398552}; DE Flags: Fragment; GN Name=MICA {ECO:0000313|Ensembl:ENSP00000398552}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000398552}; RN [1] {ECO:0000313|Ensembl:ENSP00000398552, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000398552} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR318637; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR847852; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9B8; -. DR Ensembl; ENST00000417943; ENSP00000398552; ENSG00000235233. DR HGNC; HGNC:7090; MICA. DR ChiTaRS; MICA; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9B8, KW ECO:0000213|PeptideAtlas:A0A140T9B8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 201 221 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 98 187 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000398552}. SQ SEQUENCE 276 AA; 30436 MW; 9014256E324FC493 CRC64; FPFAPPGAAA EPHSLRYNLT VLSWDGSVQS GFLAEVHLDG QPFLRYDRQK CRAKPQGQWA EDVLGNKTWD RETRDLTGNG KDLRMTLAHI KDQKEVPPMV NVTRSEASEG NITVTCRASS FYPRNITLTW RQDGVSLSHD TQQWGDVLPD GNGTYQTWVA TRICQGEEQR FTCYMEHSGN HSTHPVPSGK VLVLQSHWQT FHVSAVAAAA AAIFVIIIFY VRCCKKKTSA AEGPELVSLQ VLDQHPVGTS DHRDATQLGF QPLMSALGST GSTEGA // ID A0A140T9C2_HUMAN Unreviewed; 225 AA. AC A0A140T9C2; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 12. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000398913}; DE Flags: Fragment; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000398913}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000398913}; RN [1] {ECO:0000313|Ensembl:ENSP00000398913, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000398913} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL844851; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9C2; -. DR Ensembl; ENST00000433515; ENSP00000398913; ENSG00000206509. DR HGNC; HGNC:4963; HLA-F. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9C2, KW ECO:0000213|PeptideAtlas:A0A140T9C2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 184 208 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 85 163 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000398913}. SQ SEQUENCE 225 AA; 25194 MW; CA3A5C6E4C662C8A CRC64; XPDPPPGRVP GAFTEHAYDG KDYISLNEDL RSWTAADTVA QITQRFYEAE EYAEEFRTYL EGECLELLRR YLENGKETLQ RADPPKAHVA HHPISDHEAT LRCWALGFYP AEITLTWQRD GEEQTQDTEL VETRPAGDGT FQKWAAVVVP SGEEQRYTCH VQHEGLPQPL ILRWEQSPQP TIPIVGIVAG LVVLGAVVTG AVVAAVMWRK KSSDRNRGSY SQAAV // ID A0A140T9D4_HUMAN Unreviewed; 246 AA. AC A0A140T9D4; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 11. DE SubName: Full=HLA class I histocompatibility antigen, B-46 alpha chain {ECO:0000313|Ensembl:ENSP00000399675}; DE Flags: Fragment; GN Name=HLA-B {ECO:0000313|Ensembl:ENSP00000399675}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000399675}; RN [1] {ECO:0000313|Ensembl:ENSP00000399675, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000399675} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL662833; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL669854; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL845556; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9D4; -. DR PRIDE; A0A140T9D4; -. DR Ensembl; ENST00000445222; ENSP00000399675; ENSG00000223532. DR HGNC; HGNC:4932; HLA-B. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9D4, KW ECO:0000213|MaxQB:A0A140T9D4, ECO:0000213|PeptideAtlas:A0A140T9D4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 36 214 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 246 246 {ECO:0000313|Ensembl:ENSP00000399675}. SQ SEQUENCE 246 AA; 27691 MW; D936FD53A7CAAB49 CRC64; MASAGRSEGT AGGGAGPEEP RREEGRAGLS PSSPPGSHSM RYFDTAMSRP GRGEPRFISV GYVDDTQFVR FDSDAASPRE EPRAPWIEQE GPEYWDRNTQ IFKTNTQTDR ESLRNLRGYY NQSEAGSHTL QSMYGCDVGP DGRLLRGHNQ YAYDGKDYIA LNEDLRSWTA ADTAAQITQR KWEAARVAEQ DRAYLEGTCV EWLRRYLENG KDTLERADPP KTHVTHHPIS DHEATLRCWA LGFYPA // ID A0A140T9D8_HUMAN Unreviewed; 340 AA. AC A0A140T9D8; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 15. DE SubName: Full=MHC class I polypeptide-related sequence B {ECO:0000313|Ensembl:ENSP00000400122}; GN Name=MICB {ECO:0000313|Ensembl:ENSP00000400122}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000400122}; RN [1] {ECO:0000313|Ensembl:ENSP00000400122, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000400122} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR753820; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9D8; -. DR Ensembl; ENST00000437651; ENSP00000400122; ENSG00000224378. DR HGNC; HGNC:7091; MICB. DR PhylomeDB; A0A140T9D8; -. DR ChiTaRS; MICB; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9D8, KW ECO:0000213|PeptideAtlas:A0A140T9D8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 340 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305526. FT DOMAIN 164 259 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 37593 MW; 61A1B6DBB6896768 CRC64; MGLGRVLLFL AVAFPFAPPA AAAEPHSLRY NLMVLSQDGS VQSGFLAEGH LDGQPFLRYD RQKRRAKPQG QWAEDVLGAK TWDTETEDLT ENGQDLRRTL THIKDQKGVP QSSRAQTLAM NVTNFWKEDA MKTKTHYRAM QADCLQKLQR YLKSGVAIRR TVPPMVNVIC SEVSEGNITV TCRASSFYPR NITLTWRQDG VSLSHNTQQW GDVLPDGNGT YQTWVATRIR QGEEQRFTCY MEHSGNHGTH PVPSGKALVL QSQRTDFPYV SAAMPCFVII IILCVPCCKK KTSAAEGPEL VSLQVLDQHP VGTGDHRDAA QLGFQPLMSA TGSTGSTEGT // ID A0A140T9D9_HUMAN Unreviewed; 225 AA. AC A0A140T9D9; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 12. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000400112}; DE Flags: Fragment; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000400112}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000400112}; RN [1] {ECO:0000313|Ensembl:ENSP00000400112, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000400112} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR753818; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000420923; ENSP00000400112; ENSG00000235220. DR HGNC; HGNC:4963; HLA-F. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9D9, KW ECO:0000213|PeptideAtlas:A0A140T9D9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 184 208 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 85 163 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000400112}. SQ SEQUENCE 225 AA; 25194 MW; CA3A5C6E4C662C8A CRC64; XPDPPPGRVP GAFTEHAYDG KDYISLNEDL RSWTAADTVA QITQRFYEAE EYAEEFRTYL EGECLELLRR YLENGKETLQ RADPPKAHVA HHPISDHEAT LRCWALGFYP AEITLTWQRD GEEQTQDTEL VETRPAGDGT FQKWAAVVVP SGEEQRYTCH VQHEGLPQPL ILRWEQSPQP TIPIVGIVAG LVVLGAVVTG AVVAAVMWRK KSSDRNRGSY SQAAV // ID A0A140T9E1_HUMAN Unreviewed; 261 AA. AC A0A140T9E1; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 12. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000400410}; DE Flags: Fragment; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000400410}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000400410}; RN [1] {ECO:0000313|Ensembl:ENSP00000400410, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000400410} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL671883; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EPD; A0A140T9E1; -. DR MaxQB; A0A140T9E1; -. DR PeptideAtlas; A0A140T9E1; -. DR PRIDE; A0A140T9E1; -. DR Ensembl; ENST00000415537; ENSP00000400410; ENSG00000204525. DR HGNC; HGNC:4933; HLA-C. DR OpenTargets; ENSG00000204525; -. DR GeneTree; ENSGT00760000118960; -. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR ExpressionAtlas; A0A140T9E1; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9E1, KW ECO:0000213|MaxQB:A0A140T9E1, ECO:0000213|PeptideAtlas:A0A140T9E1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 261 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305428. FT DOMAIN 26 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000400410}. FT NON_TER 261 261 {ECO:0000313|Ensembl:ENSP00000400410}. SQ SEQUENCE 261 AA; 29545 MW; E620B720E72288C0 CRC64; XRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ RMSGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEASRRWNLP EVGSCGGAFW TRAEIHVPYA ARGAARAPHP E // ID A0A140T9G0_HUMAN Unreviewed; 241 AA. AC A0A140T9G0; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, B-46 alpha chain {ECO:0000313|Ensembl:ENSP00000401443}; DE Flags: Fragment; GN Name=HLA-B {ECO:0000313|Ensembl:ENSP00000401443}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000401443}; RN [1] {ECO:0000313|Ensembl:ENSP00000401443, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [4] {ECO:0000313|Ensembl:ENSP00000401443} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759828; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9G0; -. DR PRIDE; A0A140T9G0; -. DR Ensembl; ENST00000425798; ENSP00000401443; ENSG00000232126. DR HGNC; HGNC:4932; HLA-B. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9G0, KW ECO:0000213|MaxQB:A0A140T9G0, ECO:0000213|PeptideAtlas:A0A140T9G0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 179 204 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 82 168 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000401443}. SQ SEQUENCE 241 AA; 26549 MW; 81786EB9B98C5AF7 CRC64; XPDGRLLRGH DQSAYDGKDY IALNEDLSSW TAADTAAQIT QRKWEAAREA EQWRAYLEGL CVEWLRRYLE NGKETLQRAD PPKTHVTHHP ISDHEATLRC WALGFYPAEI TLTWQRDGED QTQDTELVET RPAGDRTFQK WAAVVVPSGE EQRYTCHVQH EGLPKPLTLR WEPSSQSTIP IVGIVAGLAV LAVVVIGAVV ATVMCRRKSS GHFLPTGGKG GSYSQAASSD SAQGSDVSLT A // ID A0A140T9H3_HUMAN Unreviewed; 241 AA. AC A0A140T9H3; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, B-46 alpha chain {ECO:0000313|Ensembl:ENSP00000403471}; DE Flags: Fragment; GN Name=HLA-B {ECO:0000313|Ensembl:ENSP00000403471}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000403471}; RN [1] {ECO:0000313|Ensembl:ENSP00000403471, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [4] {ECO:0000313|Ensembl:ENSP00000403471} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX927178; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9H3; -. DR Ensembl; ENST00000436729; ENSP00000403471; ENSG00000224608. DR HGNC; HGNC:4932; HLA-B. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9H3, KW ECO:0000213|MaxQB:A0A140T9H3, ECO:0000213|PeptideAtlas:A0A140T9H3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 181 205 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 82 168 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000403471}. SQ SEQUENCE 241 AA; 26401 MW; 9CF8DBFAD34D579C CRC64; XPDGRLLRGY DQDAYDGKDY IALNEDLSSW TAADTAAQIT QRKWEAARVA EQLRAYLEGL CVESLRRYLE NGKETLQRAD PPKTHVTHHP ISDHEVTLRC WALGFYPAEI TLTWQRDGED QTQDTELVET RPAGDRTFQK WAAVVVPSGE EQRYTCHVQH EGLPKPLTLR WEPSSQSTVP IVGIVAGLAV LAVVVIGAVV AAVMCRRKSS GHFLPTGGKG GSYSQAACSD SAQGSDVSLT A // ID A0A140T9H4_HUMAN Unreviewed; 317 AA. AC A0A140T9H4; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=MHC class I polypeptide-related sequence B {ECO:0000313|Ensembl:ENSP00000403513}; DE Flags: Fragment; GN Name=MICB {ECO:0000313|Ensembl:ENSP00000403513}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000403513}; RN [1] {ECO:0000313|Ensembl:ENSP00000403513, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000403513} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX927320; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9H4; -. DR Ensembl; ENST00000456351; ENSP00000403513; ENSG00000231372. DR HGNC; HGNC:7091; MICB. DR ChiTaRS; MICB; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9H4, KW ECO:0000213|PeptideAtlas:A0A140T9H4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 141 236 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000403513}. SQ SEQUENCE 317 AA; 35250 MW; D76E89C3653BEC12 CRC64; XPHSLRYNLM VLSQDGSVQS GFLAEGHLDG QPFLRYDRQK RRAKPQGQWA EDVLGAKTWD TETEDLTENG QDLRRTLTHI KDQKGVPQSS RAQTLAMNVT NFWKEDAMKT KTHYRAMQAD CLQKLQRYLK SGVAIRRTVP PMVNVTCSEV SEGNITVTCR ASSFYPRNIT LTWRQDGVSL SHNTQQWGDV LPDGNGTYQT WVATRIRQGE EQRFTCYMEH SGNHGTHPVP SGKALVLQSQ RTDFPYVSAA MPCFVIIIIL CVPCCKKKTS AAEGPELVSL QVLDQHPVGT GDHRDAAQLG FQPLMSATGS TGSTEGA // ID A0A140T9H5_HUMAN Unreviewed; 372 AA. AC A0A140T9H5; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000403624}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000403624}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000403624}; RN [1] {ECO:0000313|Ensembl:ENSP00000403624, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000403624} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL662833; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9H5; -. DR Ensembl; ENST00000423509; ENSP00000403624; ENSG00000233841. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9H5, KW ECO:0000213|MaxQB:A0A140T9H5, ECO:0000213|PeptideAtlas:A0A140T9H5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 372 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305471. FT TRANSMEM 306 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 372 AA; 41363 MW; B6986DC4D4373236 CRC64; MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGH FLPTGGKGGS CSQAACSNSA QGSDESLITC KA // ID A0A140T9I0_HUMAN Unreviewed; 365 AA. AC A0A140T9I0; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 15. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000403922}; DE Flags: Fragment; GN Name=HLA-A {ECO:0000313|Ensembl:ENSP00000403922}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000403922}; RN [1] {ECO:0000313|Ensembl:ENSP00000403922, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:18088087} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18088087; DOI=10.1021/pr0704130; RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., RA Schutz C., Walter U., Gambaryan S., Sickmann A.; RT "Phosphoproteome of resting human platelets."; RL J. Proteome Res. 7:526-534(2008). RN [3] {ECO:0000213|PubMed:19413330} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., RA Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in RT a refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [4] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] {ECO:0000213|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [6] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [7] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [8] {ECO:0000313|Ensembl:ENSP00000403922} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759762; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EPD; A0A140T9I0; -. DR Ensembl; ENST00000453057; ENSP00000403922; ENSG00000227715. DR HGNC; HGNC:4931; HLA-A. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9I0, KW ECO:0000213|MaxQB:A0A140T9I0, ECO:0000213|PeptideAtlas:A0A140T9I0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305590. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000403922}. SQ SEQUENCE 365 AA; 40902 MW; 53903468E35266A2 CRC64; XAVMAPRTLV LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDGETRK VKAHSQTHRV DLGTLRGYYN QSEAGSHTVQ RMYGCDVGSD WRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQTTKHK WEAAHVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDVSL TACKV // ID A0A140T9I5_HUMAN Unreviewed; 274 AA. AC A0A140T9I5; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 12. DE SubName: Full=MHC class I polypeptide-related sequence A {ECO:0000313|Ensembl:ENSP00000404397}; DE Flags: Fragment; GN Name=MICA {ECO:0000313|Ensembl:ENSP00000404397}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000404397}; RN [1] {ECO:0000313|Ensembl:ENSP00000404397, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000404397} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL845443; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9I5; -. DR Ensembl; ENST00000436191; ENSP00000404397; ENSG00000183214. DR HGNC; HGNC:7090; MICA. DR ChiTaRS; MICA; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9I5, KW ECO:0000213|PeptideAtlas:A0A140T9I5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 201 219 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 98 187 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000404397}. SQ SEQUENCE 274 AA; 30294 MW; 7984599BF39E562B CRC64; FPFAPPGAAA EPHSLRYNLT VLSWDGSVQS GFLTEVHLDG QPFLRCDRQK CRAKPQGQWA EDVLGNKTWD RETRDLTGNG KDLRMTLAHI KDQKEVPPMV NVTRSEASEG NITVTCRASG FYPWNITLSW RQDGVSLSHD TQQWGDVLPD GNGTYQTWVA TRICQGEEQR FTCYMEHSGN HSTHPVPSGK VLVLQSHWQT FHVSAVAAAA IFVIIIFYVR CCKKKTSAAE GPELVSLQVL DQHPVGTSDH RDATQLGFQP LMSDLGSTGS TEGA // ID A0A140T9J8_HUMAN Unreviewed; 242 AA. AC A0A140T9J8; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 12. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000405198}; DE Flags: Fragment; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000405198}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000405198}; RN [1] {ECO:0000313|Ensembl:ENSP00000405198, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000405198} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759790; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9J8; -. DR Ensembl; ENST00000441200; ENSP00000405198; ENSG00000234487. DR HGNC; HGNC:4963; HLA-F. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9J8, KW ECO:0000213|PeptideAtlas:A0A140T9J8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 242 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305593. FT TRANSMEM 211 237 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 22 200 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 186 206 {ECO:0000256|SAM:Coils}. FT NON_TER 242 242 {ECO:0000313|Ensembl:ENSP00000405198}. SQ SEQUENCE 242 AA; 27283 MW; 6739820D67266B43 CRC64; MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL QRAEQSPQPT IPIVGIVAGL VVLGAVVTGA VVAAVMWRKK SS // ID A0A140T9J9_HUMAN Unreviewed; 372 AA. AC A0A140T9J9; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000404526}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000404526}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000404526}; RN [1] {ECO:0000313|Ensembl:ENSP00000404526, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [3] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [4] {ECO:0000313|Ensembl:ENSP00000404526} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR388229; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9J9; -. DR Ensembl; ENST00000458192; ENSP00000404526; ENSG00000228299. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9J9, KW ECO:0000213|MaxQB:A0A140T9J9, ECO:0000213|PeptideAtlas:A0A140T9J9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 372 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305445. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 372 AA; 41622 MW; EC8E796F58635193 CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV NLRKLRGYYN QSEDGSHTLQ WMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQW RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVMAV VMCRRKSSGH FLPTGGKGGS CSQAASSNSA QGSDESLIAC KA // ID A0A140T9K3_HUMAN Unreviewed; 131 AA. AC A0A140T9K3; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000405190}; DE Flags: Fragment; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000405190}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000405190}; RN [1] {ECO:0000313|Ensembl:ENSP00000405190, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000405190} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL844851; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000418017; ENSP00000405190; ENSG00000206509. DR HGNC; HGNC:4963; HLA-F. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9K3, KW ECO:0000213|PeptideAtlas:A0A140T9K3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 131 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305392. FT DOMAIN 22 130 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 131 131 {ECO:0000313|Ensembl:ENSP00000405190}. SQ SEQUENCE 131 AA; 14764 MW; B7675BCAC46149C7 CRC64; MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL L // ID A0A140T9L3_HUMAN Unreviewed; 261 AA. AC A0A140T9L3; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000407051}; DE Flags: Fragment; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000407051}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000407051}; RN [1] {ECO:0000313|Ensembl:ENSP00000407051, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000407051} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL662833; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9L3; -. DR PRIDE; A0A140T9L3; -. DR Ensembl; ENST00000457806; ENSP00000407051; ENSG00000233841. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9L3, KW ECO:0000213|MaxQB:A0A140T9L3, ECO:0000213|PeptideAtlas:A0A140T9L3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 261 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305450. FT DOMAIN 26 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000407051}. FT NON_TER 261 261 {ECO:0000313|Ensembl:ENSP00000407051}. SQ SEQUENCE 261 AA; 29607 MW; 86FB0F5B9BD30021 CRC64; XRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEASRRWNLP EVGSCGGAFW TRAEIHVPYA ARGAARAPHP E // ID A0A140T9M0_HUMAN Unreviewed; 372 AA. AC A0A140T9M0; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 15. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000407431}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000407431}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000407431}; RN [1] {ECO:0000313|Ensembl:ENSP00000407431, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [3] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [4] {ECO:0000313|Ensembl:ENSP00000407431} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759828; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EPD; A0A140T9M0; -. DR PeptideAtlas; A0A140T9M0; -. DR Ensembl; ENST00000419135; ENSP00000407431; ENSG00000225691. DR HGNC; HGNC:4933; HLA-C. DR PhylomeDB; A0A140T9M0; -. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9M0, KW ECO:0000213|MaxQB:A0A140T9M0, ECO:0000213|PeptideAtlas:A0A140T9M0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 372 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305549. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 372 AA; 41514 MW; CF40A08F9FAC43F1 CRC64; MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTAVSRPG RGEPHFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEAGSHIIQ RMYGCDVGPD GRLLRGYDQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQL RAYLEGLCVE WLRRYLKNGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGH FLPTGGKGGS CSQAASSNSA QGSDESLIAC KA // ID A0A140T9M4_HUMAN Unreviewed; 131 AA. AC A0A140T9M4; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000407836}; DE Flags: Fragment; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000407836}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000407836}; RN [1] {ECO:0000313|Ensembl:ENSP00000407836, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000407836} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL669813; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000420414; ENSP00000407836; ENSG00000137403. DR HGNC; HGNC:4963; HLA-F. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9M4, KW ECO:0000213|PeptideAtlas:A0A140T9M4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 131 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305397. FT DOMAIN 22 130 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 131 131 {ECO:0000313|Ensembl:ENSP00000407836}. SQ SEQUENCE 131 AA; 14764 MW; B7675BCAC46149C7 CRC64; MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL L // ID A0A140T9M5_HUMAN Unreviewed; 261 AA. AC A0A140T9M5; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000407494}; DE Flags: Fragment; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000407494}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000407494}; RN [1] {ECO:0000313|Ensembl:ENSP00000407494, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000407494} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX927178; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR MaxQB; A0A140T9M5; -. DR PeptideAtlas; A0A140T9M5; -. DR PRIDE; A0A140T9M5; -. DR Ensembl; ENST00000437368; ENSP00000407494; ENSG00000237022. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9M5, KW ECO:0000213|MaxQB:A0A140T9M5, ECO:0000213|PeptideAtlas:A0A140T9M5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 261 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305482. FT DOMAIN 26 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000407494}. FT NON_TER 261 261 {ECO:0000313|Ensembl:ENSP00000407494}. SQ SEQUENCE 261 AA; 29739 MW; ED468A7CCE26FCB0 CRC64; XRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEAGSHTLQ WMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARAAEQQ RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHLVSD HEASRRWNLP EVGSCGGAFW RRAEIHVPCA ARGAAGAPHP E // ID A0A140T9M6_HUMAN Unreviewed; 383 AA. AC A0A140T9M6; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 16. DE SubName: Full=MHC class I polypeptide-related sequence B {ECO:0000313|Ensembl:ENSP00000407092}; GN Name=MICB {ECO:0000313|Ensembl:ENSP00000407092}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000407092}; RN [1] {ECO:0000313|Ensembl:ENSP00000407092, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000407092} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL662866; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EPD; A0A140T9M6; -. DR PeptideAtlas; A0A140T9M6; -. DR Ensembl; ENST00000458032; ENSP00000407092; ENSG00000234218. DR HGNC; HGNC:7091; MICB. DR PhylomeDB; A0A140T9M6; -. DR ChiTaRS; MICB; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9M6, KW ECO:0000213|PeptideAtlas:A0A140T9M6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 383 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305551. FT DOMAIN 207 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 383 AA; 42564 MW; 451F0584FD39572A CRC64; MGLGRVLLFL AVAFPFAPPA AAAEPHSLRY NLMVLSQDGS VQSGFLAEGH LDGQPFLRYD RQKRRAKPQG QWAEDVLGAE TWDTETEDLT ENGQDLRRTL THIKDQKGGL HSLQEIRVCE MHEDSSTRGS RHFYYNGELF LSQNLETQES TVPQSSRAQT LAMNVTNFWK EDAMKTKTHY RAMQADCLQK LQRYLKSGVA IRRTVPPMVN VTCSEVSEGN ITVTCRASSF YPRNITLTWR QDGVSLSHNT QQWGDVLPDG NGTYQTWVAT RIRQGEEQRF TCYMEHSGNH GTHPVPSGKA LVLQSQRTDF PYVSAAMPCF VIIIILCVPC CKKKTSAAEG PELVSLQVLD QHPVGTGDHR DAAQLGFQPL MSATGSTGST EGA // ID A0A140T9P3_HUMAN Unreviewed; 223 AA. AC A0A140T9P3; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 12. DE SubName: Full=MHC class I polypeptide-related sequence A {ECO:0000313|Ensembl:ENSP00000409422}; DE Flags: Fragment; GN Name=MICA {ECO:0000313|Ensembl:ENSP00000409422}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000409422}; RN [1] {ECO:0000313|Ensembl:ENSP00000409422, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000409422} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX005439; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX119958; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A140T9P3; -. DR SMR; A0A140T9P3; -. DR PeptideAtlas; A0A140T9P3; -. DR Ensembl; ENST00000423443; ENSP00000409422; ENSG00000231225. DR HGNC; HGNC:7090; MICA. DR PhylomeDB; A0A140T9P3; -. DR ChiTaRS; MICA; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A140T9P3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 98 187 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000409422}. SQ SEQUENCE 223 AA; 25242 MW; F30DBAC81E64A6E5 CRC64; FPFAPPGAAA EPHSLRYNLT VLSWDGSVQS GFLAEVHLDG QPFLRYDRQK CRAKPQGQWA EDVLGNKTWD RETRDLTGNG KDLRMTLAHI KDQKEVPPMV NVTRSEASEG NITVTCRASS FYPRNIILTW RQDGVSLSHD TQQWGDVLPD GNGTYQTWVA TRICRGEEQR FTCYMEHSGN HSTHPVPSGK VLVLQSHWQT FHVSAVAAGC CYFCYYYFLC PLL // ID A0A140T9P9_HUMAN Unreviewed; 131 AA. AC A0A140T9P9; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 11. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000409934}; DE Flags: Fragment; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000409934}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000409934}; RN [1] {ECO:0000313|Ensembl:ENSP00000409934, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000409934} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759790; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000414958; ENSP00000409934; ENSG00000234487. DR HGNC; HGNC:4963; HLA-F. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9P9, KW ECO:0000213|PeptideAtlas:A0A140T9P9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 131 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305555. FT DOMAIN 22 130 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 131 131 {ECO:0000313|Ensembl:ENSP00000409934}. SQ SEQUENCE 131 AA; 14764 MW; B7675BCAC46149C7 CRC64; MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL L // ID A0A140T9Q4_HUMAN Unreviewed; 261 AA. AC A0A140T9Q4; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000410661}; DE Flags: Fragment; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000410661}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000410661}; RN [1] {ECO:0000313|Ensembl:ENSP00000410661, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000410661} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX322539; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9Q4; -. DR PRIDE; A0A140T9Q4; -. DR Ensembl; ENST00000448362; ENSP00000410661; ENSG00000206452. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9Q4, KW ECO:0000213|MaxQB:A0A140T9Q4, ECO:0000213|PeptideAtlas:A0A140T9Q4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 261 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305464. FT DOMAIN 26 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000410661}. FT NON_TER 261 261 {ECO:0000313|Ensembl:ENSP00000410661}. SQ SEQUENCE 261 AA; 29977 MW; C429CEE0E6CBB1AF CRC64; XRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVQF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV NLRKLRGYYN QSEAGSHTLQ RMYGCDLGPD GRLLRGYNQF AYDGKDYIAL NEDLRSWTAA DKAAQITQRK WEAAREAEQR RAYLEGTCVE WLRRYLENGK KTLQRAEHPK THVTHHPVSD HEASRRWNLP EVGSCGGAFW RRAEIHVPCA ARGAARAPHP E // ID A0A140T9S7_HUMAN Unreviewed; 261 AA. AC A0A140T9S7; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000411867}; DE Flags: Fragment; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000411867}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000411867}; RN [1] {ECO:0000313|Ensembl:ENSP00000411867, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000411867} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX248310; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000449884; ENSP00000411867; ENSG00000206435. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9S7, KW ECO:0000213|MaxQB:A0A140T9S7, ECO:0000213|PeptideAtlas:A0A140T9S7}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 261 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305563. FT DOMAIN 26 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000411867}. FT NON_TER 261 261 {ECO:0000313|Ensembl:ENSP00000411867}. SQ SEQUENCE 261 AA; 29977 MW; C429CEE0E6CBB1AF CRC64; XRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVQF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV NLRKLRGYYN QSEAGSHTLQ RMYGCDLGPD GRLLRGYNQF AYDGKDYIAL NEDLRSWTAA DKAAQITQRK WEAAREAEQR RAYLEGTCVE WLRRYLENGK KTLQRAEHPK THVTHHPVSD HEASRRWNLP EVGSCGGAFW RRAEIHVPCA ARGAARAPHP E // ID A0A140T9S9_HUMAN Unreviewed; 241 AA. AC A0A140T9S9; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 14. DE SubName: Full=HLA class I histocompatibility antigen, B-46 alpha chain {ECO:0000313|Ensembl:ENSP00000411954}; DE Flags: Fragment; GN Name=HLA-B {ECO:0000313|Ensembl:ENSP00000411954}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000411954}; RN [1] {ECO:0000313|Ensembl:ENSP00000411954, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [4] {ECO:0000313|Ensembl:ENSP00000411954} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL845443; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX322539; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9S9; -. DR PRIDE; A0A140T9S9; -. DR Ensembl; ENST00000418147; ENSP00000411954; ENSG00000206450. DR HGNC; HGNC:4932; HLA-B. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9S9, KW ECO:0000213|MaxQB:A0A140T9S9, ECO:0000213|PeptideAtlas:A0A140T9S9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 179 204 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 82 168 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000411954}. SQ SEQUENCE 241 AA; 26408 MW; 395FD398C4FF9BD0 CRC64; XPDGRLLRGH DQSAYDGKDY IALNEDLSSW TAADTAAQIT QRKWEAARVA EQLRAYLEGT CVEWLRRHLE NGKETLQRAD PPKTHVTHHP ISDHEATLRC WALGFYPAEI TLTWQRDGED QTQDTELVET RPAGDRTFQK WAAVVVPSGE EQRYTCHVQH EGLPKPLTLR WEPSSQSTIP IVGIVAGLAV LAVVVIGAVV ATVMCRRKSS GHFLPTGGKG GSYSQAASSD SAQGSDVSLT A // ID A0A140T9T1_HUMAN Unreviewed; 261 AA. AC A0A140T9T1; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000412426}; DE Flags: Fragment; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000412426}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000412426}; RN [1] {ECO:0000313|Ensembl:ENSP00000412426, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000412426} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759828; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9T1; -. DR PRIDE; A0A140T9T1; -. DR Ensembl; ENST00000445075; ENSP00000412426; ENSG00000225691. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9T1, KW ECO:0000213|MaxQB:A0A140T9T1, ECO:0000213|PeptideAtlas:A0A140T9T1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 261 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305499. FT DOMAIN 25 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000412426}. FT NON_TER 261 261 {ECO:0000313|Ensembl:ENSP00000412426}. SQ SEQUENCE 261 AA; 29756 MW; 5EB4FABB24E59D41 CRC64; XRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTAVSRPG RGEPHFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEAGSHIIQ RMYGCDVGPD GRLLRGYDQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQL RAYLEGLCVE WLRRYLKNGK ETLQRAEHPK THVTHHPVSD HEASRRWNLP EVGSCGGAFW RRAEIHVPCA ARGAAGAPHP E // ID A0A140T9T9_HUMAN Unreviewed; 223 AA. AC A0A140T9T9; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 12. DE SubName: Full=MHC class I polypeptide-related sequence A {ECO:0000313|Ensembl:ENSP00000412989}; DE Flags: Fragment; GN Name=MICA {ECO:0000313|Ensembl:ENSP00000412989}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000412989}; RN [1] {ECO:0000313|Ensembl:ENSP00000412989, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000412989} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL669854; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A140T9T9; -. DR SMR; A0A140T9T9; -. DR Ensembl; ENST00000420744; ENSP00000412989; ENSG00000233051. DR HGNC; HGNC:7090; MICA. DR PhylomeDB; A0A140T9T9; -. DR ChiTaRS; MICA; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A140T9T9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 98 187 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000412989}. SQ SEQUENCE 223 AA; 25242 MW; F30DBAC81E64A6E5 CRC64; FPFAPPGAAA EPHSLRYNLT VLSWDGSVQS GFLAEVHLDG QPFLRYDRQK CRAKPQGQWA EDVLGNKTWD RETRDLTGNG KDLRMTLAHI KDQKEVPPMV NVTRSEASEG NITVTCRASS FYPRNIILTW RQDGVSLSHD TQQWGDVLPD GNGTYQTWVA TRICRGEEQR FTCYMEHSGN HSTHPVPSGK VLVLQSHWQT FHVSAVAAGC CYFCYYYFLC PLL // ID A0A140T9U0_HUMAN Unreviewed; 368 AA. AC A0A140T9U0; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000413189}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000413189}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000413189}; RN [1] {ECO:0000313|Ensembl:ENSP00000413189, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000413189} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759828; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9U0; -. DR Ensembl; ENST00000429840; ENSP00000413189; ENSG00000225691. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9U0, KW ECO:0000213|MaxQB:A0A140T9U0, ECO:0000213|PeptideAtlas:A0A140T9U0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 368 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305568. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 41417 MW; 0B3D50D14EA6A196 CRC64; MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTAVSRPG RGEPHFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEAGSHIIQ RMYGCDVGPD GRLLRGYDQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQL RAYLEGLCVE WLRRYLKNGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSAA CVGLRCRISS HLSFVTSRAS GISFCKGI // ID A0A140T9U8_HUMAN Unreviewed; 397 AA. AC A0A140T9U8; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 15. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000413992}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000413992}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000413992}; RN [1] {ECO:0000313|Ensembl:ENSP00000413992, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000413992} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL662833; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EPD; A0A140T9U8; -. DR Ensembl; ENST00000430940; ENSP00000413992; ENSG00000233841. DR HGNC; HGNC:4933; HLA-C. DR PhylomeDB; A0A140T9U8; -. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9U8, KW ECO:0000213|MaxQB:A0A140T9U8, ECO:0000213|PeptideAtlas:A0A140T9U8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 397 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305505. FT TRANSMEM 306 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 397 AA; 44216 MW; 573610318E5AE8FD CRC64; MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGR EGVKSGVWAA TVPRALMSLS SLVKPETAAC VGLRCRISSH LSFVTSRASG ISFCKGV // ID A0A140T9V0_HUMAN Unreviewed; 334 AA. AC A0A140T9V0; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000414318}; DE Flags: Fragment; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000414318}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000414318}; RN [1] {ECO:0000313|Ensembl:ENSP00000414318, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000414318} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759790; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000422439; ENSP00000414318; ENSG00000234487. DR HGNC; HGNC:4963; HLA-F. DR PhylomeDB; A0A140T9V0; -. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9V0, KW ECO:0000213|PeptideAtlas:A0A140T9V0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 334 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305606. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 284 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 334 334 {ECO:0000313|Ensembl:ENSP00000414318}. SQ SEQUENCE 334 AA; 37746 MW; 1EB256D61029A1F7 CRC64; MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL QRADPPKAHV AHHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPQP LILRWEQSPQ PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSS // ID A0A140T9W2_HUMAN Unreviewed; 355 AA. AC A0A140T9W2; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000415025}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000415025}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000415025}; RN [1] {ECO:0000313|Ensembl:ENSP00000415025, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000415025} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759828; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9W2; -. DR Ensembl; ENST00000433153; ENSP00000415025; ENSG00000225691. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9W2, KW ECO:0000213|MaxQB:A0A140T9W2, ECO:0000213|PeptideAtlas:A0A140T9W2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 355 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305487. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 355 AA; 39941 MW; F468D044543F139D CRC64; MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTAVSRPG RGEPHFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEAGSHIIQ RMYGCDVGPD GRLLRGYDQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQL RAYLEGLCVE WLRRYLKNGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSAS NSAQGSDESL IACKA // ID A0A140T9W3_HUMAN Unreviewed; 225 AA. AC A0A140T9W3; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 12. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000414500}; DE Flags: Fragment; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000414500}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000414500}; RN [1] {ECO:0000313|Ensembl:ENSP00000414500, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000414500} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL669813; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000454646; ENSP00000414500; ENSG00000137403. DR HGNC; HGNC:4963; HLA-F. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9W3, KW ECO:0000213|PeptideAtlas:A0A140T9W3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 184 208 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 85 163 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000414500}. SQ SEQUENCE 225 AA; 25193 MW; AEBB12BB0D28F65F CRC64; XPDPPPGRVP GAFTQHAYDG KDYISLNEDL RSWTAADTVA QITQRFYEAE EYAEEFRTYL EGECLELLRR YLENGKETLQ RADPPKAHVA HHPISDHEAT LRCWALGFYP AEITLTWQRD GEEQTQDTEL VETRPAGDGT FQKWAAVVVP SGEEQRYTCH VQHEGLPQPL ILRWEQSPQP TIPIVGIVAG LVVLGAVVTG AVVAAVMWRK KSSDRNRGSY SQAAV // ID A0A140T9W7_HUMAN Unreviewed; 225 AA. AC A0A140T9W7; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 12. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000415401}; DE Flags: Fragment; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000415401}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000415401}; RN [1] {ECO:0000313|Ensembl:ENSP00000415401, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000415401} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX927250; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000426675; ENSP00000415401; ENSG00000237508. DR HGNC; HGNC:4963; HLA-F. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9W7, KW ECO:0000213|PeptideAtlas:A0A140T9W7}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 184 208 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 85 163 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000415401}. SQ SEQUENCE 225 AA; 25194 MW; CA3A5C6E4C662C8A CRC64; XPDPPPGRVP GAFTEHAYDG KDYISLNEDL RSWTAADTVA QITQRFYEAE EYAEEFRTYL EGECLELLRR YLENGKETLQ RADPPKAHVA HHPISDHEAT LRCWALGFYP AEITLTWQRD GEEQTQDTEL VETRPAGDGT FQKWAAVVVP SGEEQRYTCH VQHEGLPQPL ILRWEQSPQP TIPIVGIVAG LVVLGAVVTG AVVAAVMWRK KSSDRNRGSY SQAAV // ID A0A140T9X5_HUMAN Unreviewed; 371 AA. AC A0A140T9X5; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 15. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000416233}; DE Flags: Fragment; GN Name=HLA-A {ECO:0000313|Ensembl:ENSP00000416233}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000416233}; RN [1] {ECO:0000313|Ensembl:ENSP00000416233, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:18088087} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18088087; DOI=10.1021/pr0704130; RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., RA Schutz C., Walter U., Gambaryan S., Sickmann A.; RT "Phosphoproteome of resting human platelets."; RL J. Proteome Res. 7:526-534(2008). RN [3] {ECO:0000213|PubMed:19413330} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., RA Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in RT a refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [4] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] {ECO:0000213|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [6] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [7] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [8] {ECO:0000313|Ensembl:ENSP00000416233} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759762; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR MaxQB; A0A140T9X5; -. DR PRIDE; A0A140T9X5; -. DR Ensembl; ENST00000455882; ENSP00000416233; ENSG00000227715. DR HGNC; HGNC:4931; HLA-A. DR PhylomeDB; A0A140T9X5; -. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9X5, KW ECO:0000213|MaxQB:A0A140T9X5, ECO:0000213|PeptideAtlas:A0A140T9X5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 371 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305493. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000416233}. SQ SEQUENCE 371 AA; 41430 MW; E57D44766632919A CRC64; XAVMAPRTLV LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDGETRK VKAHSQTHRV DLGTLRGYYN QSEAGSHTVQ RMYGCDVGSD WRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQTTKHK WEAAHVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSGGE GVKDRKGGSY SQAASSDSAQ GSDVSLTACK V // ID A0A140T9X6_HUMAN Unreviewed; 213 AA. AC A0A140T9X6; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 14. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000416426}; DE Flags: Fragment; GN Name=HLA-F {ECO:0000313|Ensembl:ENSP00000416426}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000416426}; RN [1] {ECO:0000313|Ensembl:ENSP00000416426, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000416426} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759790; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EPD; A0A140T9X6; -. DR PeptideAtlas; A0A140T9X6; -. DR Ensembl; ENST00000420024; ENSP00000416426; ENSG00000234487. DR HGNC; HGNC:4963; HLA-F. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9X6, KW ECO:0000213|PeptideAtlas:A0A140T9X6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 184 208 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 85 163 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000416426}. FT NON_TER 213 213 {ECO:0000313|Ensembl:ENSP00000416426}. SQ SEQUENCE 213 AA; 23889 MW; 6A3046FCA2B4443D CRC64; XPDPPPGRVP GAFTEHAYDG KDYISLNEDL RSWTAADTVA QITQRFYEAE EYAEEFRTYL EGECLELLRR YLENGKETLQ RADPPKAHVA HHPISDHEAT LRCWALGFYP AEITLTWQRD GEEQTQDTEL VETRPAGDGT FQKWAAVVVP SGEEQRYTCH VQHEGLPQPL ILRWEQSPQP TIPIVGIVAG LVVLGAVVTG AVVAAVMWRK KSS // ID A0A140T9Y5_HUMAN Unreviewed; 246 AA. AC A0A140T9Y5; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, B-46 alpha chain {ECO:0000313|Ensembl:ENSP00000416672}; DE Flags: Fragment; GN Name=HLA-B {ECO:0000313|Ensembl:ENSP00000416672}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000416672}; RN [1] {ECO:0000313|Ensembl:ENSP00000416672, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] {ECO:0000313|Ensembl:ENSP00000416672} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX927178; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9Y5; -. DR Ensembl; ENST00000430299; ENSP00000416672; ENSG00000224608. DR HGNC; HGNC:4932; HLA-B. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9Y5, KW ECO:0000213|MaxQB:A0A140T9Y5, ECO:0000213|PeptideAtlas:A0A140T9Y5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 36 214 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 246 246 {ECO:0000313|Ensembl:ENSP00000416672}. SQ SEQUENCE 246 AA; 27767 MW; 0FC438B0A7BD472B CRC64; MASVGRREGT AGGGAGPGEP RREEGRAGLS PSSPPGSHSM RYFYTAMSRP GRGEPRFITV GYVDDTLFVR FDSDATSPRK EPRAPWIEQE GPEYWDRETQ ISKTNTQTYR ENLRTALRYY NQSEAGSHII QRMYGCDVGP DGRLLRGYDQ DAYDGKDYIA LNEDLSSWTA ADTAAQITQR KWEAARVAEQ LRAYLEGLCV ESLRRYLENG KETLQRADPP KTHVTHHPIS DHEVTLRCWA LGFYPA // ID A0A140T9Z4_HUMAN Unreviewed; 131 AA. AC A0A140T9Z4; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000431347}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000431347}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000431347}; RN [1] {ECO:0000313|Ensembl:ENSP00000431347, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000431347} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX927178; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9Z4; -. DR PRIDE; A0A140T9Z4; -. DR Ensembl; ENST00000488273; ENSP00000431347; ENSG00000237022. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9Z4, KW ECO:0000213|MaxQB:A0A140T9Z4, ECO:0000213|PeptideAtlas:A0A140T9Z4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 131 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305517. FT DOMAIN 26 114 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 131 AA; 15120 MW; 59C4A0467ACF81E3 CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEAVDVWLR PGARRAPPPR V // ID A0A140T9Z6_HUMAN Unreviewed; 342 AA. AC A0A140T9Z6; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000432736}; GN Name=HLA-A {ECO:0000313|Ensembl:ENSP00000432736}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000432736}; RN [1] {ECO:0000313|Ensembl:ENSP00000432736, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] {ECO:0000313|Ensembl:ENSP00000432736} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR382333; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9Z6; -. DR Ensembl; ENST00000470780; ENSP00000432736; ENSG00000231834. DR HGNC; HGNC:4931; HLA-A. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9Z6, KW ECO:0000213|MaxQB:A0A140T9Z6, ECO:0000213|PeptideAtlas:A0A140T9Z6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 342 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305579. FT TRANSMEM 306 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 342 AA; 38449 MW; 8AB23F60E026CBB0 CRC64; MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDLQTRN VKAQSQTDRA NLGTLRGYYN QSEAGSHTIQ MMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VFAGAVVAAV RWRRKSSGGV KG // ID A0A140T9Z7_HUMAN Unreviewed; 131 AA. AC A0A140T9Z7; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000433088}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000433088}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000433088}; RN [1] {ECO:0000313|Ensembl:ENSP00000433088, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000433088} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR388229; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9Z7; -. DR Ensembl; ENST00000479595; ENSP00000433088; ENSG00000228299. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140T9Z7, KW ECO:0000213|MaxQB:A0A140T9Z7, ECO:0000213|PeptideAtlas:A0A140T9Z7}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 131 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305612. FT DOMAIN 26 114 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 131 AA; 15143 MW; F5B91BA50EE56DCD CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV NLRKLRGYYN QSEDVDVWLR PGARRAPPPR V // ID A0A140T9Z8_HUMAN Unreviewed; 212 AA. AC A0A140T9Z8; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=MHC class I polypeptide-related sequence A {ECO:0000313|Ensembl:ENSP00000433021}; GN Name=MICA {ECO:0000313|Ensembl:ENSP00000433021}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000433021}; RN [1] {ECO:0000313|Ensembl:ENSP00000433021, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000433021} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL845443; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140T9Z8; -. DR Ensembl; ENST00000460798; ENSP00000433021; ENSG00000183214. DR HGNC; HGNC:7090; MICA. DR ChiTaRS; MICA; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A140T9Z8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 212 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305502. FT DOMAIN 25 124 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 212 AA; 23740 MW; 7F624FF44D7CBED1 CRC64; MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLTEVH LDGQPFLRCD RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL AHIKDQKEVL QSSDLGHERQ EFLEGRCHED QDTLSRYACR LPAGTTAISK IRRSPEENSA PHGECHPQRG LRGQHYRDMQ GFWLLSLEYH TELASGWGIF EPRHPAVGGC PA // ID A0A140TA02_HUMAN Unreviewed; 224 AA. AC A0A140TA02; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 12. DE SubName: Full=HLA class I histocompatibility antigen, B-46 alpha chain {ECO:0000313|Ensembl:ENSP00000433363}; GN Name=HLA-B {ECO:0000313|Ensembl:ENSP00000433363}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000433363}; RN [1] {ECO:0000313|Ensembl:ENSP00000433363, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000433363} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL845443; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX322539; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140TA02; -. DR PRIDE; A0A140TA02; -. DR Ensembl; ENST00000479203; ENSP00000433363; ENSG00000206450. DR HGNC; HGNC:4932; HLA-B. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140TA02, KW ECO:0000213|MaxQB:A0A140TA02, ECO:0000213|PeptideAtlas:A0A140TA02}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 224 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305521. FT DOMAIN 25 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 189 209 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 224 AA; 25660 MW; B291A910BAD7CE2F CRC64; MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFHTSVSRPG RGEPRFISVG YVDGTQFVRF DSDAASPRTE PRAPWIEQEG PEYWDRNTQI SKTNTQTYRE SLRNLRGYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHDQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRHLENGK ETLQRADQEQ KSLFPAQRLE LSNE // ID A0A140TA03_HUMAN Unreviewed; 131 AA. AC A0A140TA03; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000433409}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000433409}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000433409}; RN [1] {ECO:0000313|Ensembl:ENSP00000433409, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000433409} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759828; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140TA03; -. DR PRIDE; A0A140TA03; -. DR Ensembl; ENST00000491984; ENSP00000433409; ENSG00000225691. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140TA03, KW ECO:0000213|MaxQB:A0A140TA03, ECO:0000213|PeptideAtlas:A0A140TA03}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 131 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305581. FT DOMAIN 25 115 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 131 AA; 15144 MW; D1CE4D97918A8578 CRC64; MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTAVSRPG RGEPHFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEAEDVWLR RGARRAPPPR V // ID A0A140TA05_HUMAN Unreviewed; 224 AA. AC A0A140TA05; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000433897}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000433897}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000433897}; RN [1] {ECO:0000313|Ensembl:ENSP00000433897, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000433897} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL662833; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140TA05; -. DR Ensembl; ENST00000464914; ENSP00000433897; ENSG00000233841. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140TA05, KW ECO:0000213|MaxQB:A0A140TA05, ECO:0000213|PeptideAtlas:A0A140TA05}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 224 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305613. FT DOMAIN 26 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 224 AA; 25641 MW; 8B7986E7C0EC8DFA CRC64; MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK ETLQRAGQDQ KSLFLPQRLE LSNE // ID A0A140TA11_HUMAN Unreviewed; 224 AA. AC A0A140TA11; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 11. DE SubName: Full=HLA class I histocompatibility antigen, B-46 alpha chain {ECO:0000313|Ensembl:ENSP00000435083}; GN Name=HLA-B {ECO:0000313|Ensembl:ENSP00000435083}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000435083}; RN [1] {ECO:0000313|Ensembl:ENSP00000435083, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] {ECO:0000313|Ensembl:ENSP00000435083} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX248310; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140TA11; -. DR Ensembl; ENST00000498484; ENSP00000435083; ENSG00000228964. DR HGNC; HGNC:4932; HLA-B. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140TA11, KW ECO:0000213|MaxQB:A0A140TA11, ECO:0000213|PeptideAtlas:A0A140TA11}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 224 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305507. FT DOMAIN 25 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 189 209 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 224 AA; 25867 MW; 0AA66838E8B28D54 CRC64; MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFITVG YVDDTLFVRF DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE NLRTALRYYN QSEAGSHIIQ RMYGCDVGPD GRLLRGYDQD AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQD RAYLEGLCVE SLRRYLENGK ETLQRADQEQ KSLFPAQRLE LSNE // ID A0A140TA12_HUMAN Unreviewed; 131 AA. AC A0A140TA12; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000435957}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000435957}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000435957}; RN [1] {ECO:0000313|Ensembl:ENSP00000435957, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000435957} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL662833; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140TA12; -. DR Ensembl; ENST00000476248; ENSP00000435957; ENSG00000233841. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140TA12, KW ECO:0000213|MaxQB:A0A140TA12, ECO:0000213|PeptideAtlas:A0A140TA12}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 131 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305436. FT DOMAIN 26 115 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 131 AA; 15074 MW; 048F9FFFFDE8C7C2 CRC64; MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQADRV SLRNLRGYYN QSEDEDVWLR PGARRAPPPR V // ID A0A140TA13_HUMAN Unreviewed; 224 AA. AC A0A140TA13; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, B-46 alpha chain {ECO:0000313|Ensembl:ENSP00000435221}; GN Name=HLA-B {ECO:0000313|Ensembl:ENSP00000435221}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000435221}; RN [1] {ECO:0000313|Ensembl:ENSP00000435221, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [3] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [4] {ECO:0000313|Ensembl:ENSP00000435221} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR759828; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140TA13; -. DR PRIDE; A0A140TA13; -. DR Ensembl; ENST00000471639; ENSP00000435221; ENSG00000232126. DR HGNC; HGNC:4932; HLA-B. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140TA13, KW ECO:0000213|MaxQB:A0A140TA13, ECO:0000213|PeptideAtlas:A0A140TA13}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 224 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305525. FT DOMAIN 25 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 224 AA; 25774 MW; 771F39ECB667542F CRC64; MRVTAPRTVL LLLSGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRMA PRAPWIEQEG PEYWDRETQI SKTNTQTYRE SLRNLRGYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHDQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQW RAYLEGLCVE WLRRYLENGK ETLQRADQEQ KSLFPAQRLE LSNE // ID A0A140TA14_HUMAN Unreviewed; 224 AA. AC A0A140TA14; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 11. DE SubName: Full=HLA class I histocompatibility antigen, B-46 alpha chain {ECO:0000313|Ensembl:ENSP00000435817}; GN Name=HLA-B {ECO:0000313|Ensembl:ENSP00000435817}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000435817}; RN [1] {ECO:0000313|Ensembl:ENSP00000435817, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] {ECO:0000313|Ensembl:ENSP00000435817} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX927178; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140TA14; -. DR Ensembl; ENST00000481283; ENSP00000435817; ENSG00000224608. DR HGNC; HGNC:4932; HLA-B. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140TA14, KW ECO:0000213|MaxQB:A0A140TA14, ECO:0000213|PeptideAtlas:A0A140TA14}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 224 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305583. FT DOMAIN 25 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 189 209 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 224 AA; 25865 MW; 0AA66838E238A5FC CRC64; MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFITVG YVDDTLFVRF DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE NLRTALRYYN QSEAGSHIIQ RMYGCDVGPD GRLLRGYDQD AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGLCVE SLRRYLENGK ETLQRADQEQ KSLFPAQRLE LSNE // ID A0A140TA19_HUMAN Unreviewed; 224 AA. AC A0A140TA19; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 10. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000436842}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000436842}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000436842}; RN [1] {ECO:0000313|Ensembl:ENSP00000436842, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000436842} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX248310; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A140TA19; -. DR Ensembl; ENST00000461937; ENSP00000436842; ENSG00000206435. DR HGNC; HGNC:4933; HLA-C. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140TA19, KW ECO:0000213|MaxQB:A0A140TA19, ECO:0000213|PeptideAtlas:A0A140TA19}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 224 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305510. FT DOMAIN 26 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 224 AA; 25989 MW; 93B04DD7FF22B5D4 CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVQF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV NLRKLRGYYN QSEAGSHTLQ RMYGCDLGPD GRLLRGYNQF AYDGKDYIAL NEDLRSWTAA DKAAQITQRK WEAAREAEQR RAYLEGTCVE WLRRYLENGK KTLQRAGQDQ KSLFLPQRLE LSNE // ID A0A140TA21_HUMAN Unreviewed; 224 AA. AC A0A140TA21; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 23-MAY-2018, entry version 12. DE SubName: Full=HLA class I histocompatibility antigen, B-46 alpha chain {ECO:0000313|Ensembl:ENSP00000436637}; GN Name=HLA-B {ECO:0000313|Ensembl:ENSP00000436637}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000436637}; RN [1] {ECO:0000313|Ensembl:ENSP00000436637, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000436637} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL662833; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL669854; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL845556; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EPD; A0A140TA21; -. DR PeptideAtlas; A0A140TA21; -. DR PRIDE; A0A140TA21; -. DR Ensembl; ENST00000461583; ENSP00000436637; ENSG00000223532. DR HGNC; HGNC:4932; HLA-B. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A140TA21, KW ECO:0000213|MaxQB:A0A140TA21, ECO:0000213|PeptideAtlas:A0A140TA21}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 224 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305528. FT DOMAIN 25 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 224 AA; 25744 MW; 3360E2E394A435DF CRC64; MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFDTAMSRPG RGEPRFISVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI FKTNTQTDRE SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARVAEQD RAYLEGTCVE WLRRYLENGK DTLERADQEQ KSLFPAQRLE LSNE // ID A0A151LY29_ALLMI Unreviewed; 226 AA. AC A0A151LY29; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 28-FEB-2018, entry version 8. DE SubName: Full=Major histocompatibility complex class I-related protein-like {ECO:0000313|EMBL:KYO17167.1}; GN ORFNames=Y1Q_0008589 {ECO:0000313|EMBL:KYO17167.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO17167.1}; RN [1] {ECO:0000313|EMBL:KYO17167.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO17167.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO17167.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03007077; KYO17167.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}. FT DOMAIN 50 141 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 226 AA; 24963 MW; 19012395025E62EB CRC64; MVTPAGFHCY RHLYMGVLDP SQGVPYFTAM SYVDDQKILH YDSETRRQEP QHPVAQVSNR PSWDRCTIVS CRVHSFYPRD VAVVWLKNGE AQPQETNRSG VLPSGDGTYQ TWATIEIDPS SNHNYTCSVE HKSLGAALRV AWDKGRTERA GRAAEHGAAH NEAAPAQEAV EREAFEAAEK EAVESEASDA MEREALESEA LASKALASSR AAEVSPRHVG QLDCEH // ID A0A151M1B8_ALLMI Unreviewed; 351 AA. AC A0A151M1B8; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 8. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO18301.1}; GN ORFNames=Y1Q_0012783 {ECO:0000313|EMBL:KYO18301.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO18301.1}; RN [1] {ECO:0000313|EMBL:KYO18301.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO18301.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO18301.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03006834; KYO18301.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 309 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 212 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 351 AA; 39682 MW; 6C0AB0D6FD01AB2A CRC64; MSILCGPPWE VAVSNGGPGI CPLVLTITPA GSHRYQHFYM GVSDPSPGMP DFTARGYVDD QQILHYDSKT RRQEPRGDWV QRAVRPDFWD RETRSLQGWQ GVFQSNLVTL RYRYNQTGGS HTLQFMYGCE LHEHNSTGGH MLFGYDGEDF ISYDLRTRTW VAAPTQAEST QSRWNKDKAL LQDARSYLEE TCIEWLRKYL QHGEAALQSK HPMAQVSDRP SQDGRTTLSC RVHDFYPRDV AVVWLKNGEV QPETNRAGVL PSGDGTYQTW ATIEIDPSSN HNYTCSVEHE SLGAALRVSW DKGQTESNWV LIMGITFGVL LVIATMSAVA NFFCLREPAP SPEGPMEKER K // ID A0A151M1E2_ALLMI Unreviewed; 327 AA. AC A0A151M1E2; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 8. DE SubName: Full=Major histocompatibility complex class I-related protein-like {ECO:0000313|EMBL:KYO18300.1}; GN ORFNames=Y1Q_0012783 {ECO:0000313|EMBL:KYO18300.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO18300.1}; RN [1] {ECO:0000313|EMBL:KYO18300.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO18300.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO18300.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03006834; KYO18300.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 285 309 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 188 275 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 327 AA; 37251 MW; DDF493971844151C CRC64; MPGTSAGSHR YQHFYMGVSD PSPGMPDFTA RGYVDDQQIL HYDSKTRRQE PRGDWVQRAV RPDFWDRETR SLQGWQGVFQ SNLVTLRYRY NQTGGSHTLQ FMYGCELHEH NSTGGHMLFG YDGEDFISYD LRTRTWVAAP TQAESTQSRW NKDKALLQDA RSYLEETCIE WLRKYLQHGE AALQSKHPMA QVSDRPSQDG RTTLSCRVHD FYPRDVAVVW LKNGEVQPET NRAGVLPSGD GTYQTWATIE IDPSSNHNYT CSVEHESLGA ALRVSWDKGQ TESNWVLIMG ITFGVLLVIA TMSAVANFFC LREPAPSPEG PMEKERK // ID A0A151MLU7_ALLMI Unreviewed; 391 AA. AC A0A151MLU7; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 8. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO25495.1}; GN ORFNames=Y1Q_0017073 {ECO:0000313|EMBL:KYO25495.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO25495.1}; RN [1] {ECO:0000313|EMBL:KYO25495.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO25495.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO25495.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03005763; KYO25495.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 345 373 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 248 336 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 391 AA; 43745 MW; 7310EE772FBB9829 CRC64; MQHHVPRLPA RGGHGRNRRR THPVLELWAL PFLQFQCQDL SPPPGAMAWA LALWMCWGLL EAAAASGLHH LDILVTGADE EDGTHNYFMI AKLNNFVVAN YRSNTQEVRP TKEWVKRALG ADYVQQQTLE FQGYEKVSKV HRKRWMKLYN QTDGLHVEQV HVGCSLSGDV LGDQKFQYAY DGEDFISFDI QQLTWVAAVP VAFAQKMRWD NDETWTQFVQ WYLKEKCLQT LKSLLQEGKA ILAQRVSPTV SVSRKDATDG SASLSCHVRG FYPRPIHVLW VQEGGEILPE TFTSGILPTA NNTFYTWTSL EVGPASAMHR YACRVEHSSL PEPSLTWVPD KKVTLLPVVL AVLIIAGGMI LIGSVLGCAS VWIKKSAGIA QSGYTPASTK S // ID A0A151MUF0_ALLMI Unreviewed; 242 AA. AC A0A151MUF0; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 5. DE SubName: Full=RT1 class I histocompatibility antigen, AA alpha chain-like {ECO:0000313|EMBL:KYO28136.1}; GN ORFNames=Y1Q_0023912 {ECO:0000313|EMBL:KYO28136.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO28136.1}; RN [1] {ECO:0000313|EMBL:KYO28136.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO28136.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO28136.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03005033; KYO28136.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}. FT DOMAIN 54 227 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 242 AA; 27490 MW; 62C8084CA76D8C6E CRC64; MAALGETPFP SDWARRELPR PEAPHEASAK VAPGSRLLLL LVGVAAVPGI GAGSQSYWYF YMGVSDPGLD MLDFTAVVYV GDQQILHYDS ETQRQEPRGN WVQGAVGLDS WNRETRTLQG WQEVFKWNLL ALQHHYKQTS GSHTLQFMYG CQLGEDGSTR RCMQFGCDGG DFISYDLGMQ TSAAETTQAQ ITQRKWNEDK YKLQYLRAYL EGTCIEWLRQ YLQHREAALQ SSESRCHRPG QR // ID A0A151MUH4_ALLMI Unreviewed; 205 AA. AC A0A151MUH4; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 5. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO28135.1}; GN ORFNames=Y1Q_0023912 {ECO:0000313|EMBL:KYO28135.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO28135.1}; RN [1] {ECO:0000313|EMBL:KYO28135.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO28135.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO28135.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03005033; KYO28135.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}. FT DOMAIN 103 190 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 205 AA; 22126 MW; CB7DC1F01E3EE5FF CRC64; MTTFSGSFLF PAEAQPVSLS PGSNTCKGPP NQDYNTNQEA SDPAAPCRLH RSPLHPSLCG STCSSCAQRP EAPHEASAKV APGSRLLLLL VGVAAVPGIG AGSQSYWYFY MGVSDPGLDM LDFTAVVYVG DQQILHYDSE TQRQEPRGNW VQGAVGLDSW NRETRTLQGW QEVFKWNLLA LQHHYKQTSG ECEQEAVGGP GAEGN // ID A0A151MUK2_ALLMI Unreviewed; 232 AA. AC A0A151MUK2; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 5. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO28134.1}; GN ORFNames=Y1Q_0023912 {ECO:0000313|EMBL:KYO28134.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO28134.1}; RN [1] {ECO:0000313|EMBL:KYO28134.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO28134.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO28134.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03005033; KYO28134.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}. FT DOMAIN 130 217 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 232 AA; 24631 MW; AE4AD7DCF58A2EE4 CRC64; MTTFSGSFLF PAEAQPVSLS PGSNTCKGPP NQDYNTNQEA PGAGAAPQQE SQALGPAHTA PSPSAPQSDP AAPCRLHRSP LHPSLCGSTC SSCAQRPEAP HEASAKVAPG SRLLLLLVGV AAVPGIGAGS QSYWYFYMGV SDPGLDMLDF TAVVYVGDQQ ILHYDSETQR QEPRGNWVQG AVGLDSWNRE TRTLQGWQEV FKWNLLALQH HYKQTSGECE QEAVGGPGAE GN // ID A0A151MYR4_ALLMI Unreviewed; 237 AA. AC A0A151MYR4; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 5. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO29585.1}; GN ORFNames=Y1Q_0013165 {ECO:0000313|EMBL:KYO29585.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO29585.1}; RN [1] {ECO:0000313|EMBL:KYO29585.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO29585.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO29585.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03004635; KYO29585.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}. FT DOMAIN 10 81 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 237 AA; 25703 MW; C3B05CFCC289F352 CRC64; MAMSSTKTTA LEATCGLATR GEDSISYDPG TCIWVAETTQ AQITQRRWNE DKAALQDARY YLEETCTARL RKYLQHGEEA LQSSECWCHH PGQHGNAHSI LLCPGCPALL WDTMPLSLPL PGLLVGQSPR GVCDLATCLR TRDQLMSHGT GERQAISGWT HHPVLPGPQL LPQERQATEH GAARYEAAPA QEAVEREAFK AAEKEAVESE ASDAMEREAL ESEALASKAS ASSGSFG // ID A0A151MZ52_ALLMI Unreviewed; 236 AA. AC A0A151MZ52; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 7. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO29725.1}; GN ORFNames=Y1Q_0023217 {ECO:0000313|EMBL:KYO29725.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO29725.1}; RN [1] {ECO:0000313|EMBL:KYO29725.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO29725.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO29725.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03004513; KYO29725.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.40.128.30; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036896; Avidin-like_sf. DR InterPro; IPR005468; Avidin/str. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF01382; Avidin; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF50876; SSF50876; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS51326; AVIDIN_2; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 136 157 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 3 71 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 70 119 IGc1. {ECO:0000259|Pfam:PF07654}. SQ SEQUENCE 236 AA; 26677 MW; 1C21860CCA4EF373 CRC64; MVYVDDQHIL HYDSETRRQE PRGDWVQGAI GPDFQNMETM YLQGWQDGFK QNLVTLRHHY NQTRGCPVAQ LENGEAQPQE TSCSWVLPSG DGTYQTWATI EIDSSSNHDY TCSVEHVSLG AALKVAWDKG RMESDLMPTV IMLVILVMAT TVTAVTFCNM CWTKPSGPGL RYAHEAPDSE SSESCDSTTV FVGQCFKDKS GEESLRTMWL LREEVNSKKD DWKTTRTSSN IFTRIA // ID A0A151MZD9_ALLMI Unreviewed; 315 AA. AC A0A151MZD9; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 28-FEB-2018, entry version 12. DE SubName: Full=Major histocompatibility complex class I-related protein-like {ECO:0000313|EMBL:KYO29877.1}; GN ORFNames=Y1Q_0009496 {ECO:0000313|EMBL:KYO29877.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO29877.1}; RN [1] {ECO:0000313|EMBL:KYO29877.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO29877.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO29877.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03004483; KYO29877.1; -; Genomic_DNA. DR RefSeq; XP_019350937.1; XM_019495392.1. DR GeneID; 102567483; -. DR KEGG; amj:102567483; -. DR KO; K06751; -. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 275 308 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 179 259 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 315 AA; 35825 MW; 264FB50354F513BF CRC64; MDTWDTAADR HPGAFLLSPL DVPDFTAVAY VDDQLLLHYN SKTQREEPRG DWVQGAVSPH FWDKETRALR RWQEGFDTNL ATLWYRYNQM GGSRTLQLTY SCELHEDNST GGHMQLGYDR GDFISYDPGT RTWIAAPTQA QRTQHTWNED RALLQDTKAY LEETCVAWLQ QYLLQSKHPV AQVSDRPSQD GRTTLSCWVH GFYPKNISVV WLKNGEGQTQ ETSHSGVLLS GDGTYQTWAT MEIDPSNNHD YACLVEHASL GLVLCVSWDK GRTEYHWMLI VGIVVGVVLI LVIVVMGAAV FFLSLVLLEG RRKQQ // ID A0A151N0X1_ALLMI Unreviewed; 171 AA. AC A0A151N0X1; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 5. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F-like {ECO:0000313|EMBL:KYO30377.1}; GN ORFNames=Y1Q_0006453 {ECO:0000313|EMBL:KYO30377.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO30377.1}; RN [1] {ECO:0000313|EMBL:KYO30377.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO30377.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO30377.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03004228; KYO30377.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}. FT DOMAIN 67 155 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 171 AA; 19025 MW; 6EF6711C4E152BBC CRC64; MVTTDPAASC GLRCGPLRPS LRGSTLRVCA QRLDAAHEAA AKVAPGSRLL LLLLLLGAET VPGAHAGSHS YRHFYTAVSD PSLDVPVFTA VGYVDDQQIL RYDSETQRQE PRGDWVQGAV DQDFWDGETR SLRRWQDGFK RNLLTLRHRY NQTGGECEQA GVSRRPWGPW H // ID A0A151NB89_ALLMI Unreviewed; 337 AA. AC A0A151NB89; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 8. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO34104.1}; GN ORFNames=Y1Q_0016788 {ECO:0000313|EMBL:KYO34104.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO34104.1}; RN [1] {ECO:0000313|EMBL:KYO34104.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO34104.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO34104.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03003605; KYO34104.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 275 297 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 177 263 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 337 AA; 37559 MW; D37B19FBF8BF3A8A CRC64; MAGPHHLDIL VTGADEEDGT HNYFMIAKVD DLCLPSITAT PDPLRSSHRL RYFYTGVSEP GPGMPEFVTV GYVDDQLFTH YDSETRRTQT RVDWMKQEGL EYWDRMNQIM RAWQERFRVD LSTLQERYNQ TGGCHTLQFM YGCELGKNDT PGGDFQYGYD GGDFLRYDLK TQSWTAPKAQ VSSKPSQDGL TTLSCRVHGF YPRDISVVWL KNGVAQPQET SRSGVVPNGD GTYQTWATIE IKPSSNHDYT CSAEHVSLGA ALRVAWDKSR TESNLMLIVG IITAVVFVIA VMGAALYCRT PPSAGGNVWQ DTKQHLPVKA QTALRAAMAP TPASNIT // ID A0A151NBB3_ALLMI Unreviewed; 366 AA. AC A0A151NBB3; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 18-JUL-2018, entry version 15. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO34103.1}; GN ORFNames=Y1Q_0016787 {ECO:0000313|EMBL:KYO34103.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO34103.1}; RN [1] {ECO:0000313|EMBL:KYO34103.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO34103.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO34103.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03003605; KYO34103.1; -; Genomic_DNA. DR RefSeq; XP_006274996.1; XM_006274934.3. DR GeneID; 102574471; -. DR KEGG; amj:102574471; -. DR KO; K06751; -. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007585899. FT TRANSMEM 312 335 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 40622 MW; 4832DE15BDAF31CA CRC64; MGAGGDGSPA AVRTVLGLLL LLLAAAAGAG YHRLDVQVIG TDEEEGDYNY FMIARVDDFV FATYQSETQE FRPTQDWVKR ALGAGYVREQ TREFRGYAKG SKANVKSWMK LYNQTSGLHV EQVHVGCSLS SDVLGDQKFQ YAYDGEDFIS FDIQRQTWVA AVPVAFAQKL WWENSKTWTQ FVQWYLKEKC LETLKSLLQE GRAILAQKVS PVVSVSRRNG PDGSVSLSCH VRGFYPRPIQ VSWVQEGGEI LPETFTSGIL PTTNDTFYLW TSLELAPTSA MRRYACQVEH SSLPETLLTW VPDRMDTPPP GVLATFIVAG GLILVVAILG VVIFWRKKSG GITKPSYAPA STEMIPESSL VIRNSN // ID A0A151NBH8_ALLMI Unreviewed; 107 AA. AC A0A151NBH8; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 5. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO34140.1}; GN ORFNames=Y1Q_0012820 {ECO:0000313|EMBL:KYO34140.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO34140.1}; RN [1] {ECO:0000313|EMBL:KYO34140.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO34140.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO34140.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03003587; KYO34140.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}. FT DOMAIN 6 93 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 107 AA; 11865 MW; 00EA71FB9FD56309 CRC64; MGAGVGSHTL QFMYGCEVGE DGSTGGFMQV GYDGGGFISY DLGTCTWVAG TTQARVTQRR WNEDKILLRL TRSYLEETCI GWLRQYLQHG EAALQSSESR CHRPGQH // ID A0A151NC89_ALLMI Unreviewed; 329 AA. AC A0A151NC89; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 8. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO34105.1}; GN ORFNames=Y1Q_0016788 {ECO:0000313|EMBL:KYO34105.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO34105.1}; RN [1] {ECO:0000313|EMBL:KYO34105.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO34105.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO34105.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03003605; KYO34105.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 275 297 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 177 263 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 329 AA; 36750 MW; F44843D1A39F74B9 CRC64; MAGPHHLDIL VTGADEEDGT HNYFMIAKVD DLCLPSITAT PDPLRSSHRL RYFYTGVSEP GPGMPEFVTV GYVDDQLFTH YDSETRRTQT RVDWMKQEGL EYWDRMNQIM RAWQERFRVD LSTLQERYNQ TGGCHTLQFM YGCELGKNDT PGGDFQYGYD GGDFLRYDLK TQSWTAPKAQ VSSKPSQDGL TTLSCRVHGF YPRDISVVWL KNGVAQPQET SRSGVVPNGD GTYQTWATIE IKPSSNHDYT CSAEHVSLGA ALRVAWDKSR TESNLMLIVG IITAVVFVIA VMGAALYCRT PPSAGGNVWQ DTKQHLRAAM APTPASNIT // ID A0A151NDM4_ALLMI Unreviewed; 414 AA. AC A0A151NDM4; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 8. DE SubName: Full=Major histocompatibility complex class I-related protein-like {ECO:0000313|EMBL:KYO34894.1}; GN ORFNames=Y1Q_0016246 {ECO:0000313|EMBL:KYO34894.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO34894.1}; RN [1] {ECO:0000313|EMBL:KYO34894.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO34894.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO34894.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03003279; KYO34894.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 287 310 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 188 274 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 414 AA; 45939 MW; 3DB273E7ED3E0815 CRC64; MPGTSAGSHC YRHFYMGVSE PGPGVPVFTA MGYVDDQRIL HYDSETQRQE PRGDWVQGAV SPDFWDTETW TLWDWQDRFE SNLVTLRDRY NQTRGSHTLQ FMYGCELHED KSTGGYMQFG YDGGDFVSYD LGTRTWVAEI TQAQVTQRRW NEDKALLQDA RAYLEETCIA WLRQFLQHGE AAQQSKRPMA QVSDRPSRDG RTTLACWVHS FYPKNISVVW LRNGEAQPQK TSCSGVLPSG DGTFQTWATI EIDPSSDHDY TCSVEHVSLG AALRVAWDKG RAESTRMLAV GIVIGVVLPV VAVMGAAGYF RSSSFMGCGP RSKPSPGVEA AAVTDLCLLS SGRRGVGHRA VLHRAVPAHE ALQSQAPERE TQEREALESC RLVQGQDDTI SGAELSSCNI PCILSLKGQV WSQG // ID A0A151NEE3_ALLMI Unreviewed; 384 AA. AC A0A151NEE3; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 8. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO34895.1}; GN ORFNames=Y1Q_0016246 {ECO:0000313|EMBL:KYO34895.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO34895.1}; RN [1] {ECO:0000313|EMBL:KYO34895.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO34895.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO34895.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03003279; KYO34895.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 287 310 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 188 274 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 384 AA; 43101 MW; 24F7CA52B87051C7 CRC64; MPGTSAGSHC YRHFYMGVSE PGPGVPVFTA MGYVDDQRIL HYDSETQRQE PRGDWVQGAV SPDFWDTETW TLWDWQDRFE SNLVTLRDRY NQTRGSHTLQ FMYGCELHED KSTGGYMQFG YDGGDFVSYD LGTRTWVAEI TQAQVTQRRW NEDKALLQDA RAYLEETCIA WLRQFLQHGE AAQQSKRPMA QVSDRPSRDG RTTLACWVHS FYPKNISVVW LRNGEAQPQK TSCSGVLPSG DGTFQTWATI EIDPSSDHDY TCSVEHVSLG AALRVAWDKG RAESTRMLAV GIVIGVVLPV VAVMGAAGYF RRRRGVGHRA VLHRAVPAHE ALQSQAPERE TQEREALESC RLVQGQDDTI SGAELSSCNI PCILSLKGQV WSQG // ID A0A151NLE9_ALLMI Unreviewed; 364 AA. AC A0A151NLE9; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 8. DE SubName: Full=Major histocompatibility complex class I-related protein-like {ECO:0000313|EMBL:KYO37627.1}; GN ORFNames=Y1Q_0002224 {ECO:0000313|EMBL:KYO37627.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO37627.1}; RN [1] {ECO:0000313|EMBL:KYO37627.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO37627.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO37627.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03002635; KYO37627.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 40 65 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 268 356 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 40963 MW; 17424F450EF6F1E1 CRC64; MDMLPQSTQS PRGTSSCEDP ARSTSRITPQ KIRSRACSKA FWICIGCIAM LLLLLLILVL SVVLYKTLWP HVTLHLTNTL VPSSRPRSHS YRYFYTGVSD PSPDVPAFTA VGYVDDQQIL HYNSKTQRQE PRGDWVQGAV DPGFWDKETR ALHGWQEGFD TNLATLRYRY NQTGGSHTLQ FTYGCELHED SSTGGHMQWC YNGGDFISYD PGTRTWVAGT TQAQRTQHSW NEDQAVLQRT RAYLEGTCIA RLQQYLQRGE AALRSKRPVA QASKRPSQDG RTTLSCHVHS FYPKDISVVW LDNGEAQTQE TSRSEVLPSG DGTYQTWATI KIDQSSKHDY TCSVEHVSLG AALKVSWDKG RTGE // ID A0A151NLQ5_ALLMI Unreviewed; 280 AA. AC A0A151NLQ5; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 28-FEB-2018, entry version 6. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO37670.1}; GN ORFNames=Y1Q_0003693 {ECO:0000313|EMBL:KYO37670.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO37670.1}; RN [1] {ECO:0000313|EMBL:KYO37670.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO37670.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO37670.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03002616; KYO37670.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 25 50 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 216 240 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 74 160 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 280 AA; 30688 MW; 4A9F76314A628580 CRC64; MVHVSLGAAL SVSWDKNRTE YDPTMIMGIV TGVVLLVVLV FAISVAAVTL RNCEARESES SGISPVPGTS TSFHSYQHLY TGVSDPGPDV PAFTAVSYVD DQQILHYDSE TQRQEPRADW VLGAIEPDFW KGETMSLRSW QDGFKRNLVT LQHRYNQTXX XCEQADYQCL PGGDLHRVAV EVPAVRGGSA AAHVEHESLG AALRESWDKG RTKSDLIPIV GIVIGFVAVA IGIIVCHLYF PDPRWGQMLS TAACMDHSLH TPGQEGPGQQ RPLQQDLDFI // ID A0A151NQ05_ALLMI Unreviewed; 388 AA. AC A0A151NQ05; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 28-FEB-2018, entry version 9. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO38917.1}; GN ORFNames=Y1Q_0019424 {ECO:0000313|EMBL:KYO38917.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO38917.1}; RN [1] {ECO:0000313|EMBL:KYO38917.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO38917.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO38917.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03002413; KYO38917.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 333 354 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 230 332 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 388 AA; 42920 MW; 7B813D8FADA385AA CRC64; MWGWACNAGE SMWGHETPLG VEVDGGDQAQ VTQCSWNEDQ ASLQQVRSYL ETCIKGLQKC AVRIGSASIV PVPLSHNHNQ TERPVVLVSD RPRTSAAAGD ELIRLSLLPA FLHGGVGSQP RHPPQASEHT SLSPSQRSYT LQFMYGCELG EDNSTEGYMQ FGYDGEDFIS YDLRTHTWVA VPTQAQVTQS RWNGDKNLLL IVRAYLEGKC IEWLRKYLQH GKAALQSKSP MSQVSDRPSS WAGLTTLSCQ VHGFYPKNIS VVWLKNGEAQ PQETSCSGVL PSGDGTYQTW ATIEIDPNNN HNYTCCVEHV SLGADLRVAW DKSRQKPESS LNLALVITIV LVIIAAMSTA IYFLRKRGPG HRAETVEQSQ LQHPLQSSAE PREARDNS // ID A0A151NQ07_ALLMI Unreviewed; 423 AA. AC A0A151NQ07; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 28-FEB-2018, entry version 9. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO38916.1}; GN ORFNames=Y1Q_0019424 {ECO:0000313|EMBL:KYO38916.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO38916.1}; RN [1] {ECO:0000313|EMBL:KYO38916.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO38916.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO38916.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03002413; KYO38916.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 368 389 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 265 367 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 423 AA; 47398 MW; CCCE793079A8EE3A CRC64; MWGWACNAGE SMWGHETPLG VEVDGGDQAQ VTQCSWNEDQ ASLQQVRSYL ETCIKGLQKC AVRIGSASIV PVPLSHNHNQ TERPVVLVSD RPRTSAAAGD ELIRLSLLPA FLHGGVGSQP SETRREEPRG DWVQGAVNPD FWERETRSLR GWQQGFEGNQ VTLRHWYNQT DWSYTLQFMY GCELGEDNST EGYMQFGYDG EDFISYDLRT HTWVAVPTQA QVTQSRWNGD KNLLLIVRAY LEGKCIEWLR KYLQHGKAAL QSKSPMSQVS DRPSSWAGLT TLSCQVHGFY PKNISVVWLK NGEAQPQETS CSGVLPSGDG TYQTWATIEI DPNNNHNYTC CVEHVSLGAD LRVAWDKSRQ KPESSLNLAL VITIVLVIIA AMSTAIYFLR KRGPGHRAET VEQSQLQHPL QSSAEPREAR DNS // ID A0A151NQ35_ALLMI Unreviewed; 338 AA. AC A0A151NQ35; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 28-FEB-2018, entry version 9. DE SubName: Full=Major histocompatibility complex class I-related protein-like {ECO:0000313|EMBL:KYO38893.1}; GN ORFNames=Y1Q_0017882 {ECO:0000313|EMBL:KYO38893.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO38893.1}; RN [1] {ECO:0000313|EMBL:KYO38893.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO38893.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO38893.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03002427; KYO38893.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 338 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007586254. FT TRANSMEM 294 317 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 196 283 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 338 AA; 37721 MW; A3A42D8F55790C5D CRC64; MLLSLLLAGA VVVTGGSHSY QYFYTGLSDP DSGLPDFMAV SYVDNQEIFC YNSKMHREDR CANWVQEAVD PDFWESEIRS LRGWQRGFRK NLVTLQHRYN QTSGSHTLQL MYGCELGEDD STRGYMQFGY DGGDFISYDL SMRTWVAVVP QAQITQYILN EDNAALQLTR AYLKETCIKW LKMYLEHGKA ALQSKPPMAQ VNDRSSRDGL ATLSCRVHGF YPKDVAVVWL KNGEPQTQET SRSGVVPSGD GTYQTWATIE IDPSSNHDYT CHVEHVSLGA DLRVAWEKKP ESSLMLIVGF VIAVVLVLVV AGAAVFFCRR QGAGYKAAST RDGSNSSA // ID A0A151NQ40_ALLMI Unreviewed; 344 AA. AC A0A151NQ40; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 28-FEB-2018, entry version 9. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO38894.1}; GN ORFNames=Y1Q_0017882 {ECO:0000313|EMBL:KYO38894.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO38894.1}; RN [1] {ECO:0000313|EMBL:KYO38894.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO38894.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO38894.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03002427; KYO38894.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 344 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007586268. FT TRANSMEM 294 317 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 196 283 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 344 AA; 38194 MW; 51FC25854C088604 CRC64; MLLSLLLAGA VVVTGGSHSY QYFYTGLSDP DSGLPDFMAV SYVDNQEIFC YNSKMHREDR CANWVQEAVD PDFWESEIRS LRGWQRGFRK NLVTLQHRYN QTSGSHTLQL MYGCELGEDD STRGYMQFGY DGGDFISYDL SMRTWVAVVP QAQITQYILN EDNAALQLTR AYLKETCIKW LKMYLEHGKA ALQSKPPMAQ VNDRSSRDGL ATLSCRVHGF YPKDVAVVWL KNGEPQTQET SRSGVVPSGD GTYQTWATIE IDPSSNHDYT CHVEHVSLGA DLRVAWEKKP ESSLMLIVGF VIAVVLVLVV AGAAVFFCRR QGAGYKAAST RDGSNSSGSL GSAA // ID A0A151NR02_ALLMI Unreviewed; 385 AA. AC A0A151NR02; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 28-FEB-2018, entry version 9. DE SubName: Full=Major histocompatibility complex class I-related protein-like {ECO:0000313|EMBL:KYO38915.1}; GN ORFNames=Y1Q_0019424 {ECO:0000313|EMBL:KYO38915.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO38915.1}; RN [1] {ECO:0000313|EMBL:KYO38915.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO38915.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO38915.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03002413; KYO38915.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 330 351 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 227 329 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 385 AA; 42369 MW; 711D6CD71A64F4D8 CRC64; MWGWACNAGE SMWGHETPLG VEVDGGDQAQ VTQCSWNEDQ ASLQQVRSYL ETCIKGLQKC AVRIGSASIV PVPLSHNHNQ TASTPGAGRR TSAAAGDELI RLSLLPAFLH GGVGSQPRHP PQASEHTSLS PSQRSYTLQF MYGCELGEDN STEGYMQFGY DGEDFISYDL RTHTWVAVPT QAQVTQSRWN GDKNLLLIVR AYLEGKCIEW LRKYLQHGKA ALQSKSPMSQ VSDRPSSWAG LTTLSCQVHG FYPKNISVVW LKNGEAQPQE TSCSGVLPSG DGTYQTWATI EIDPNNNHNY TCCVEHVSLG ADLRVAWDKS RQKPESSLNL ALVITIVLVI IAAMSTAIYF LRKRGPGHRA ETVEQSQLQH PLQSSAEPRE ARDNS // ID A0A151NY54_ALLMI Unreviewed; 350 AA. AC A0A151NY54; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 28-FEB-2018, entry version 13. DE SubName: Full=MHC BF1 class I {ECO:0000313|EMBL:KYO41714.1}; GN Name=BF1 {ECO:0000313|EMBL:KYO41714.1}; GN ORFNames=Y1Q_0008579 {ECO:0000313|EMBL:KYO41714.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO41714.1}; RN [1] {ECO:0000313|EMBL:KYO41714.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO41714.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO41714.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03001623; KYO41714.1; -; Genomic_DNA. DR RefSeq; XP_014463457.1; XM_014607971.2. DR GeneID; 102561818; -. DR KEGG; amj:102561818; -. DR KO; K06751; -. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 350 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007586488. FT TRANSMEM 295 318 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 197 284 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 350 AA; 39320 MW; F4A487A3E8A2B37C CRC64; MAALFVLVAV LALAEANPGS HRMRYFYTAV SEPGPGLPEF GTVGYVDDQL FVHYDSEIKK TLPRVDWMKE GPEYWDRETQ KFQGWQERFR VDLGTLRGRY NQTGGFHTIQ VMYGCELGKD NSIRGYEQYA YDGGDFISYD LSRQTWVAVP AEAQITQRKW NADRALLQQR RDYYEGICIQ WLQKYLQYRK EALQSKPPMA QVSDRSSRDG LATLSCRVHG FYPKDVTVVW LKNGEPQTQE TSRSGVVPSG DGTYQTWATI EIDPSSNHNY TCHVEHVSLG ADLRVAWDKK PESNLMLIVG IVIAVVLVLV AAGAAVFFCR RQGAGYKAAS TRDSSNSSGS NHGSDPCVKA // ID A0A151P0Z5_ALLMI Unreviewed; 338 AA. AC A0A151P0Z5; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 22-NOV-2017, entry version 8. DE SubName: Full=RT1 class I histocompatibility antigen, AA alpha chain-like {ECO:0000313|EMBL:KYO42529.1}; GN ORFNames=Y1Q_0020513 {ECO:0000313|EMBL:KYO42529.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO42529.1}; RN [1] {ECO:0000313|EMBL:KYO42529.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO42529.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO42529.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03001389; KYO42529.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro. DR CDD; cd08330; CARD_ASC_NALP1; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR001315; CARD. DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD. DR InterPro; IPR011029; DEATH-like_dom_sf. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00619; CARD; 1. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF47986; SSF47986; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50209; CARD; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT DOMAIN 28 118 CARD. {ECO:0000259|PROSITE:PS50209}. SQ SEQUENCE 338 AA; 38098 MW; A2B8085FB2FAA284 CRC64; MRASREQDPS IDSSRSNQLP RRAANNMANP AERHFINSFR KDLINMTREV NQVIDELFDN GVLSQEQYDT IRSKSTKQEQ MRELYDYVAG WDEESKDQLY EALRKYNEPL IRKLRGTLQA RGRRAPRGGR DAAVPEPGLE QSLSGAGTSR LPGTAAEVER ETVQFMNKKL ALAPCGLRHG PWRPSLRGST CNVCAQRLEA PQEAAAKKLL LLLVAAVAVP GTSAGSHSYR HLYTAVSDPS PDVPHFTAVS YMDDQQILHY DSETQRQEPR GDWVQGAVDQ DFWEGETMSL RAWQRGFKRN LRTLQYYYNQ TEAGSSCSRR GREAVVVSGA VSHLRQAE // ID A0A151P4I3_ALLMI Unreviewed; 344 AA. AC A0A151P4I3; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 28-FEB-2018, entry version 13. DE SubName: Full=Major histocompatibility complex class I-related protein-like {ECO:0000313|EMBL:KYO43977.1}; GN ORFNames=Y1Q_0016622 {ECO:0000313|EMBL:KYO43977.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO43977.1}; RN [1] {ECO:0000313|EMBL:KYO43977.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO43977.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO43977.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03001019; KYO43977.1; -; Genomic_DNA. DR RefSeq; XP_019338349.1; XM_019482804.1. DR GeneID; 102560891; -. DR KEGG; amj:102560891; -. DR KO; K06751; -. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 344 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007586663. FT TRANSMEM 303 325 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 344 AA; 38272 MW; BEAE62E4544D08BF CRC64; MAPTLLLLLL AAAVSAAGPD GYHHLDVLIT ATVDDEETHK YFMIAKVDDF VFANYHSNTQ EFRPTQKWVK RALGDDYAQE KTREFQGYDR GAKAHIKRWM KLYNQTGGLQ VEQIHVGCSL NGGVLGGQKF QYAYNGEDFI SFDIQQQTWV AAVPVAHHQK LWWDSGKTWT QFVQWYLKEK CLQTLKSLLQ EGKAILAQRV SPVVSVSHRD APDGSSTLSC HVRGFYPRPI HVSWVQEGGE ILPETFTSGI LPTANGTFYL WTTLELAPMS TMRRYACQVE HSSLLEPSLT WVPNETGILS PGVLASLIVG GMILVIAVLG CAIVWRKKSA GIAKPDYSPA STES // ID A0A151P4N2_ALLMI Unreviewed; 401 AA. AC A0A151P4N2; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 22-NOV-2017, entry version 10. DE SubName: Full=Major histocompatibility complex class I-related protein-like {ECO:0000313|EMBL:KYO44006.1}; GN ORFNames=Y1Q_0019426 {ECO:0000313|EMBL:KYO44006.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO44006.1}; RN [1] {ECO:0000313|EMBL:KYO44006.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO44006.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO44006.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03000987; KYO44006.1; -; Genomic_DNA. DR PhylomeDB; A0A151P4N2; -. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 2. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT DOMAIN 215 311 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 401 AA; 44903 MW; 5D3379DBE954E166 CRC64; MPGPSSAAPP GGGSEHPRAL ASAPTCADPC QSPTGSHSYW YFYTGVSDPS LDVPASTAVG YMDDQKILHY DSETRRQEPC GNWAQGVVGP DFCDNETRSL QGWQQEFGVN LGTLRQRYNQ TDESHTLQFM YGFELHEDGS TGGYMQFGSD GEDFISYDLG TRTWIAVPAQ AQITQRRWNE DKILFQIARA YLEESCIKWL QKYLQHGKAA LLSKPPKTQV SDRPSSQDGL TTLSCRVHCF YPKEVAVVWL KNGEAQPQEM SHSGVIPSGD GTYQTWATIN INPSSNHDYT CSMEHVSLGE HLQAARDKSM MHVPAFTAMS YMDDQQILHY DSETRREEPR GDCVQGAVDP DFWDGETRSL RGWQWGFEAN LVTLWQRYNQ TSSDCGQTGM DRTMEDPGPE G // ID A0A151P4T6_ALLMI Unreviewed; 344 AA. AC A0A151P4T6; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 28-FEB-2018, entry version 14. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain-like {ECO:0000313|EMBL:KYO43980.1}; GN ORFNames=Y1Q_0016625 {ECO:0000313|EMBL:KYO43980.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO43980.1}; RN [1] {ECO:0000313|EMBL:KYO43980.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO43980.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO43980.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03001019; KYO43980.1; -; Genomic_DNA. DR RefSeq; XP_006278367.2; XM_006278305.3. DR GeneID; 102561593; -. DR KEGG; amj:102561593; -. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 344 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007586660. FT TRANSMEM 302 325 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 344 AA; 38628 MW; 3DA3ED713CDA88C5 CRC64; MAWALVLQIC GGLLAAVAAS GPHHLDILVT GTEEENGTHT YFMIAKLDEF VVANYSSDTQ EVRPTQEWVK RAVGSDYMQE LTHRFQRYEK GSKVHIKSWM KVYNHTDGLH VEQVHVGCSL SGDVLGDQKF QYAYDGEDFI NFDIQQQTWV AAVPVAFAQK LRWESHKTWT QYVQWYLKEK CQQTLKSLLQ EGKAILAQRV SPKVSVSRRD APDGSTTLSC HVRDFYPRPI HVSWVQEGGE ILLETFTGGI LPTANNTFYT WTSLELGPAS TMHHYACRVE HSSLPEPSLT WVSDKTDTLS PWVLAVLIMA GSMTLVITVL GYAIIRRKKS GITQSGYAPA STKS // ID A0A151P576_ALLMI Unreviewed; 352 AA. AC A0A151P576; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 28-FEB-2018, entry version 9. DE SubName: Full=Major histocompatibility complex class I-related protein-like {ECO:0000313|EMBL:KYO44221.1}; GN ORFNames=Y1Q_0007688 {ECO:0000313|EMBL:KYO44221.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO44221.1}; RN [1] {ECO:0000313|EMBL:KYO44221.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO44221.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO44221.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03000827; KYO44221.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 323 347 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 221 301 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 352 AA; 39431 MW; 5525AA1FF317014D CRC64; MPAWPAAPGP SSAAPPGGGN EHPRALASAP TSADPCHSPT GSHSYQYFYT GVSDPGSDVP AFTALGYMDD QQILHYDSET RREEPRGDWV QGAVDPDFWD RETWALRGWQ EGFEGNLITL QFRYNQTDGS HTLQFMYGCE IHEDGSTGGY MRLGYDEREF ISYDLITCTW VAVPTQARIT QRKWNEDKSL LQYTRAYLEE ECIAWLRKYL QHGTAALQSK PPKAQVSNRL LFQDGLTTLS CWVHGFYPKK ISVVWLKNGE AQPQEMSHSG VIPSGDGTYQ TRATIEIDPS SNHDYICSVK HVSLGVDLRV AWDKSRKEPE SSMMLIVGII IAVVLVIALL GAALYFLRRW GT // ID A0A151P587_ALLMI Unreviewed; 364 AA. AC A0A151P587; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 9. DE SubName: Full=H-2 class I histocompatibility antigen, Q9 alpha chain-like {ECO:0000313|EMBL:KYO44222.1}; GN ORFNames=Y1Q_0007689 {ECO:0000313|EMBL:KYO44222.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO44222.1}; RN [1] {ECO:0000313|EMBL:KYO44222.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO44222.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO44222.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03000827; KYO44222.1; -; Genomic_DNA. DR PhylomeDB; A0A151P587; -. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 294 318 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 193 284 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 40733 MW; FA1F4EF897B00930 CRC64; MGAVSVLVTS TGSHSYRSFY TGVSDPGPDL PAFTALSYVD DQQILHYDSE TQRVEPRADW VQGAVDPDYW DRETETLQGW EQKFGVKLRT LQFRYNQTGG SHTLQLMYSC ELGEDGSPGA YVKLGYDGRD FLSYDPKKRT WAAAPAETQV TQRRLNEYKA FLQSAATYME ETCIEWLRKY LQHGKAALQS KHPVAQVNDR LSSRDGLTTL SCWVHGFYPK DVAVVWLKNG EAQPQETSRS RVLPSGDGTY QIWATIKINP SRSHDYTCSV EHVSLGAALR VALDKSRVEP EFNLMLITGL VVTVVLVVAV SGSAVSFLRR QGVGYRAAPA KWIPVKSAPP PEGLMEEERE QHRATHFSLF APSF // ID A0A151P588_ALLMI Unreviewed; 378 AA. AC A0A151P588; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 8. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO44224.1}; GN ORFNames=Y1Q_0007689 {ECO:0000313|EMBL:KYO44224.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO44224.1}; RN [1] {ECO:0000313|EMBL:KYO44224.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO44224.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO44224.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03000827; KYO44224.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 303 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 378 AA; 42731 MW; 0E6F2D27A66DB406 CRC64; MASWLSKAQV TKQLLLARKI CSHSYRSFYT GVSDPGPDLP AFTALSYVDD QQILHYDSET QRVEPRADWV QGAVDPDYWD RETETLQGWE QKFGVKLRTL QFRYNQTGGS HTLQLMYSCE LGEDGSPGAY VKLGYDGRDF LSYDPKKRTW AAAPAETQVT QRRLNEYKAF LQSAATYMEE TCIEWLRKYL QHGKAALQSK HPVAQVNDRL SSRDGLTTLS CWVHGFYPKD VAVVWLKNGE AQPQETSRSR VLPSGDGTYQ IWATIKINPS RSHDYTCSVE HVSLGAALRV ALDKSRVEPE FNLMLITGLV VTVVLVVAVS GSAVSFLRRQ GVGEHYHSNT YLNTKWIPVK SAPPPEGLME EEREQHRATH FSLFAPSF // ID A0A151P5E2_ALLMI Unreviewed; 373 AA. AC A0A151P5E2; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 8. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO44223.1}; GN ORFNames=Y1Q_0007689 {ECO:0000313|EMBL:KYO44223.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO44223.1}; RN [1] {ECO:0000313|EMBL:KYO44223.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO44223.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO44223.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03000827; KYO44223.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 303 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 373 AA; 42000 MW; 71FF68ED51A912E5 CRC64; MASWLSKAQV TKQLLLARKI CSHSYRSFYT GVSDPGPDLP AFTALSYVDD QQILHYDSET QRVEPRADWV QGAVDPDYWD RETETLQGWE QKFGVKLRTL QFRYNQTGGS HTLQLMYSCE LGEDGSPGAY VKLGYDGRDF LSYDPKKRTW AAAPAETQVT QRRLNEYKAF LQSAATYMEE TCIEWLRKYL QHGKAALQSK HPVAQVNDRL SSRDGLTTLS CWVHGFYPKD VAVVWLKNGE AQPQETSRSR VLPSGDGTYQ IWATIKINPS RSHDYTCSVE HVSLGAALRV ALDKSRVEPE FNLMLITGLV VTVVLVVAVS GSAVSFLRRQ GVGYRAAPAK WIPVKSAPPP EGLMEEEREQ HRATHFSLFA PSF // ID A0A151P5H3_ALLMI Unreviewed; 220 AA. AC A0A151P5H3; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 7. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO44220.1}; GN ORFNames=Y1Q_0007687 {ECO:0000313|EMBL:KYO44220.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO44220.1}; RN [1] {ECO:0000313|EMBL:KYO44220.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO44220.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO44220.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03000827; KYO44220.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}. FT DOMAIN 135 220 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 220 AA; 25391 MW; D7B8CD7C9F86A39C CRC64; MDEDGSHSCQ SFYMEVLDPG PDVLAFTALN YVDDLPIMYY NRSHNLQLLY ECELRGDSVI RGFQKYDYDG ELLFSYDTST RAWVAVVPQA QVTQHRWNED QAGFQQVRSY LEETCNEWLQ KYVGYGKKAL QRKRPTVWVS NRPSSWDGLT TLSCQVYGSY PKDSISVIWQ ENGEEQLQET SCLGVVPSGG GIYQTWARIE IDPSSNHNYT CYVEHMSLDR // ID A0A151P5I3_ALLMI Unreviewed; 357 AA. AC A0A151P5I3; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 28-FEB-2018, entry version 9. DE SubName: Full=Major histocompatibility complex class I-related protein-like {ECO:0000313|EMBL:KYO44005.1}; GN ORFNames=Y1Q_0019425 {ECO:0000313|EMBL:KYO44005.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO44005.1}; RN [1] {ECO:0000313|EMBL:KYO44005.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO44005.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO44005.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03000987; KYO44005.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 357 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007586697. FT TRANSMEM 310 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 357 AA; 40120 MW; DA4F89747294A891 CRC64; MSKPLHLVWL LIWLLGAMGI ARATAALAGP HTLQYLLTAV SEPSPGLPEF TMQGYVDGEL FVEYDGEAQQ MRPRAAWMRA APPMLWESEN RVHKLRQGCF RGKVRSLLHL YNQSQGFHIF QYAYGCEIQA DGGTRGFRHL GFDGEEFLTY DTVEHRWLAP IAEATAEATQ HHWNGNNAAL QYYRNFLERE CPKILRRYLE YGHSPRPQSK PPKAQVSDKP SSRDGLTTLS CRVHGFYPRD AAVVWLKNGE AQPQETSLSG VIPSGDGTYQ TWATIEINPS SNHSYTCSVE HVSLGAALRV AWDKKPKSKL LLIVGIVIAV VLVIIMMGTA IYFLRKWGAG YKAVFLEQPQ VHHLCKS // ID A0A151PGL7_ALLMI Unreviewed; 196 AA. AC A0A151PGL7; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 5. DE SubName: Full=H-2 class I histocompatibility antigen, L-D alpha chain-like {ECO:0000313|EMBL:KYO48246.1}; GN ORFNames=Y1Q_0010620 {ECO:0000313|EMBL:KYO48246.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO48246.1}; RN [1] {ECO:0000313|EMBL:KYO48246.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO48246.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO48246.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AKHW03000242; KYO48246.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}. FT DOMAIN 29 130 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 196 AA; 22287 MW; E29625A0893EC83E CRC64; MPLLREQPAG QKASTTKRLT TRNGYNPETQ ETQEWWRGGN TRCQVWNPWI ETEFKALVQA VNASSPGTEL YYMQVLHTCD LDEATGAITI VTRLALNGED ILHYRGDQKQ WYHTHPAAQR LAEKWNQERQ KLEGMNTPSP QQCRFLIQTT APFCAQKTAK PNVHLSLIPA SQGQPQSLAC HVTGFYPRDI EHNALC // ID A0A1B0GSK0_MOUSE Unreviewed; 154 AA. AC A0A1B0GSK0; DT 05-OCT-2016, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 1. DT 28-MAR-2018, entry version 9. DE SubName: Full=IgG receptor FcRn large subunit p51 {ECO:0000313|Ensembl:ENSMUSP00000147969}; DE Flags: Fragment; GN Name=Fcgrt {ECO:0000313|Ensembl:ENSMUSP00000147969, GN ECO:0000313|MGI:MGI:103017}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000147969, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000147969, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000147969, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000147969} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000147969}; RG Ensembl; RL Submitted (JUL-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC126256; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; A0A1B0GSK0; -. DR Ensembl; ENSMUST00000211085; ENSMUSP00000147969; ENSMUSG00000003420. DR MGI; MGI:103017; Fcgrt. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000000589; Chromosome 7. DR ExpressionAtlas; A0A1B0GSK0; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|MaxQB:A0A1B0GSK0, KW ECO:0000213|PeptideAtlas:A0A1B0GSK0}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 154 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008408684. FT DOMAIN 16 153 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 154 154 {ECO:0000313|Ensembl:ENSMUSP00000147969}. SQ SEQUENCE 154 AA; 17632 MW; 570202954B1DC7EC CRC64; MGMPLPWALS LLLVLLPQTW GSGWLGPQQY LTYNSLRQEA DPCGAWMWEN QVSWYWEKET TDLKSKEQLF LEALKTLEKI LNGTYTLQGL LGCELASDNS SVPTAVFALN GEEFMKFNPR IGNWTGEWPE TEIVANLWMK QPDAARKESE FLLN // ID A0A1B8XUY5_XENTR Unreviewed; 260 AA. AC A0A1B8XUY5; DT 02-NOV-2016, integrated into UniProtKB/TrEMBL. DT 02-NOV-2016, sequence version 1. DT 25-OCT-2017, entry version 5. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OCA14475.1}; GN ORFNames=XENTR_v90026714mg {ECO:0000313|EMBL:OCA14475.1}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|EMBL:OCA14475.1, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|EMBL:OCA14475.1, ECO:0000313|Proteomes:UP000008143} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|EMBL:OCA14475.1, RC ECO:0000313|Proteomes:UP000008143}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KV461579; OCA14475.1; -; Genomic_DNA. DR UniGene; Str.38352; -. DR Proteomes; UP000008143; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 233 255 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 137 225 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 260 AA; 30159 MW; F8385AD2E05C9D7D CRC64; MKERLEPQHW ETMTSWGKHY QNCHTKDMGF FIDRFNNTYG DRGPFIYQVN FACEVHEDGG VSGHEAFAFN GNEFMFFDKG NMRFVPVRRE AEVIAQVWNG QQFSAIKHKN HMEQDCVQWM ALYLRYGKGR LEKKVQPTVK VFSRESDGAT KLYCWVYGFY PRDVDVRWVR NGTEEDSEEH KEILPNPDGT YQIRITLTMQ PADVDSYSCH VDHSSVNGTQ IYKLPEPDKR GHVIVIACVA VVFIMAVAVV VAAVLKFKRE // ID A0ZXL5_CHICK Unreviewed; 360 AA. AC A0ZXL5; F1NS77; DT 23-JAN-2007, integrated into UniProtKB/TrEMBL. DT 23-JAN-2007, sequence version 1. DT 12-SEP-2018, entry version 98. DE SubName: Full=MHC class I alpha chain 1 {ECO:0000313|EMBL:BAF63003.1}; DE SubName: Full=MHC class I antigen alpha chain {ECO:0000313|EMBL:CAK49240.1}; GN Name=BF1 {ECO:0000313|EMBL:CAK49240.1, GN ECO:0000313|Ensembl:ENSGALP00000045408}; OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Phasianinae; Gallus. OX NCBI_TaxID=9031 {ECO:0000313|EMBL:CAK49240.1}; RN [1] {ECO:0000313|Ensembl:ENSGALP00000045408, ECO:0000313|Proteomes:UP000000539} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000045408, RC ECO:0000313|Proteomes:UP000000539}; RX PubMed=15592404; DOI=10.1038/nature03154; RG International Chicken Genome Sequencing Consortium; RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., RA Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., RA Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., RA Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C., RA Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., RA Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., RA Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., RA Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., RA Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., RA Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., RA van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., RA Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., RA Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., RA Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., RA Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., RA Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., RA Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., RA Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., RA King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., RA Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., RA Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., RA Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., RA Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., RA Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., RA Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., RA Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., RA Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., RA Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., RA Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., RA Mardis E.R., Wilson R.K.; RT "Sequence and comparative analysis of the chicken genome provide RT unique perspectives on vertebrate evolution."; RL Nature 432:695-716(2004). RN [2] {ECO:0000313|EMBL:CAK49240.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=0 {ECO:0000313|EMBL:CAK49243.1}, and RC N {ECO:0000313|EMBL:CAK49240.1}; RX PubMed=17442958; RA Shaw I., Powell T.J., Marston D.A., Baker K., van Hateren A., RA Riegert P., Wiles M.V., Milne S., Beck S., Kaufman J.; RT "Different evolutionary histories of the two classical class I genes RT BF1 and BF2 illustrate drift and selection within the stable MHC RT haplotypes of chickens."; RL J. Immunol. 178:5744-5752(2007). RN [3] {ECO:0000313|EMBL:BAF63003.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=17513765; DOI=10.4049/jimmunol.178.11.7162; RA Shiina T., Briles W.E., Goto R.M., Hosomichi K., Yanagiya K., RA Shimizu S., Inoko H., Miller M.M.; RT "Extended gene map reveals tripartite motif, C-type lectin, and Ig RT superfamily type genes within a subregion of the chicken MHC-B RT affecting infectious disease."; RL J. Immunol. 178:7162-7172(2007). RN [4] {ECO:0000313|EMBL:BAG69410.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=15I5 {ECO:0000313|EMBL:BAG69410.1}, and RC Cornell-N {ECO:0000313|EMBL:BAG69452.1}; RX PubMed=18714011; RA Hosomichi K., Miller M.M., Goto R.M., Wang Y., Suzuki S., Kulski J.K., RA Nishibori M., Inoko H., Hanzawa K., Shiina T.; RT "Contribution of mutation, recombination, and gene conversion to RT chicken MHC-B haplotype diversity."; RL J. Immunol. 181:3393-3399(2008). RN [5] {ECO:0000313|Ensembl:ENSGALP00000045408} RP IDENTIFICATION. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000045408}; RG Ensembl; RL Submitted (OCT-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AADN04000555; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AB268588; BAF63003.1; -; Genomic_DNA. DR EMBL; AB426149; BAG69410.1; -; Genomic_DNA. DR EMBL; AB426152; BAG69452.1; -; Genomic_DNA. DR EMBL; AM279339; CAK49240.1; -; Genomic_DNA. DR EMBL; AM279342; CAK49243.1; -; Genomic_DNA. DR RefSeq; NP_001038148.2; NM_001044683.2. DR UniGene; Gga.46150; -. DR UniGene; Gga.4973; -. DR STRING; 9031.ENSGALP00000000233; -. DR Ensembl; ENSGALT00000066783; ENSGALP00000045408; ENSGALG00000033932. DR GeneID; 693260; -. DR KEGG; gga:693260; -. DR CTD; 693260; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; TESWIAP; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000000539; Chromosome 16. DR Bgee; ENSGALG00000000178; Expressed in 11 organ(s), highest expression level in female gonad. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000539}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000539}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 360 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014296707. FT TRANSMEM 303 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 360 AA; 39713 MW; 21FC7305D9E9F9AD CRC64; MRPCGAVGLG LLRLGLLLAA VCGAAAELHT LRYIHTAMTD PGPGQPWYVD VGYVDGELFV HYNSTARRYV PRTEWMAAKA DQQYWDGQTQ IGQRNERSVK VSLDTLQERY NQTGGSHTVQ WMFGCDILED GTIRGYRQVA YDGKDFIAFD KDMKTFTAAV PEAVPTKRKW EEGGVAEGWK SYLEETCVEW LRRYVEYGKA ELGRRERPEV RVWGKEADGI LTLSCRAHGF YPRPIVVSWL KDGAVRGQDA QSGGIMPNGD GTYHTWVTID AQPGDGDKYQ CRVEHASLPQ PGLYSWEPPQ PNLVPIVAGV AVAIVAIAIV VGVGFIIYRR HAGKKGKGYN IAPDREGGSS SSSTGSNPSI // ID A2AEA2_HUMAN Unreviewed; 372 AA. AC A2AEA2; DT 20-FEB-2007, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 2. DT 12-SEP-2018, entry version 94. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000372819}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000372819}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000372819, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000372819, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000372819} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL671883; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A2AEA2; -. DR EPD; A2AEA2; -. DR MaxQB; A2AEA2; -. DR PeptideAtlas; A2AEA2; -. DR PRIDE; A2AEA2; -. DR Ensembl; ENST00000383329; ENSP00000372819; ENSG00000204525. DR UCSC; uc021yuk.2; human. DR EuPathDB; HostDB:ENSG00000204525.15; -. DR HGNC; HGNC:4933; HLA-C. DR OpenTargets; ENSG00000204525; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR OMA; QRVYGCD; -. DR OrthoDB; EOG091G09OH; -. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204525; Expressed in 234 organ(s), highest expression level in mononuclear cell. DR ExpressionAtlas; A2AEA2; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:A2AEA2, KW ECO:0000213|MaxQB:A2AEA2, ECO:0000213|PeptideAtlas:A2AEA2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 372 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002642659. FT TRANSMEM 306 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 372 AA; 41301 MW; 87ABCE80D072D061 CRC64; MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ RMSGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGH FLPTGGKGGS CSQAACSNSA QGSDESLITC KA // ID A2BF26_HUMAN Unreviewed; 397 AA. AC A2BF26; DT 20-FEB-2007, integrated into UniProtKB/TrEMBL. DT 20-FEB-2007, sequence version 1. DT 18-JUL-2018, entry version 103. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000383245}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000383245}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000383245, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000383245, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000383245} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [4] {ECO:0000313|Ensembl:ENSP00000372975} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX248310; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX322539; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR MaxQB; A2BF26; -. DR PRIDE; A2BF26; -. DR Ensembl; ENST00000383483; ENSP00000372975; ENSG00000206435. DR Ensembl; ENST00000400395; ENSP00000383245; ENSG00000206452. DR UCSC; uc063ysb.1; human. DR HGNC; HGNC:4933; HLA-C. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:A2BF26, KW ECO:0000213|MaxQB:A2BF26, ECO:0000213|PeptideAtlas:A2BF26}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 397 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014565270. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 397 AA; 44532 MW; A3D5C39F002242D7 CRC64; MRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVQF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV NLRKLRGYYN QSEAGSHTLQ RMYGCDLGPD GRLLRGYNQF AYDGKDYIAL NEDLRSWTAA DKAAQITQRK WEAAREAEQR RAYLEGTCVE WLRRYLENGK KTLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWGP SSQPTIPIVG IVAGLAVLAV LAVLGAVMAV VMCRRKSSGR EGVRSGVWPA TVPRALMSLS SLVKPETAAC VGLRCRISSH LSFVTSRASG ISFCKGI // ID A3FEZ5_MACMU Unreviewed; 362 AA. AC A3FEZ5; DT 20-MAR-2007, integrated into UniProtKB/TrEMBL. DT 20-MAR-2007, sequence version 1. DT 12-SEP-2018, entry version 87. DE SubName: Full=MHC class 1 protein {ECO:0000313|EMBL:CUS58388.1}; DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:ABN48408.1}; DE SubName: Full=MHC class I protein {ECO:0000313|EMBL:CDM15073.1}; GN Name=Mamu-B {ECO:0000313|EMBL:ABN48408.1}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544; RN [1] {ECO:0000313|EMBL:ABN48408.1} RP NUCLEOTIDE SEQUENCE. RA Wallace L.T., Rudersdorf R., Watkins D.I.; RT "MHC class I genes of the Indian rhesus macaque."; RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CDM15073.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=SK002 {ECO:0000313|EMBL:CDM15073.1}; RA Karl J.A., Otting N., De Groot N.G., Wiseman R.W., O'Connor D.H.; RT "MHC class I transcripts in Chinese rhesus macaques."; RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:CUS58388.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=GD016 {ECO:0000313|EMBL:CUS58388.1}; RA Otting N., Wiseman R., Karl J.A., Doxiadis G.G.M., Bontrop R.E.; RT "New MHC class I alleles in rhesus macaques (Macaca mulatta)."; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; EF372278; ABN48408.1; -; mRNA. DR EMBL; HG813266; CDM15073.1; -; mRNA. DR EMBL; LN899678; CUS58388.1; -; mRNA. DR UniGene; Mmu.11212; -. DR STRING; 9544.ENSMMUP00000033412; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR OMA; VPGYYNQ; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Bgee; ENSMMUG00000029561; Expressed in 14 organ(s), highest expression level in CD4-positive helper T cell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5010102759. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40419 MW; CC8A427A8BAEB7B5 CRC64; MRVMAPRTLL LLLSGALALT ETWAGSHSLR YFSTTVSWPG RGEPRFISVG YVDDTQFVRF DSDAESPREE PRAPWAEQEG PEYWEEQTRN TEAHAQNHRV CLRTVPGYYN QSEAGSHTLQ RMFGCDLGPD GRLLRGYNQY AYDGKDYIAL NEDLRSWTSA DVAAQNTQRK WEATRYAERF RAYLEETCVE SLRRHLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWGA VVVPSGEEQR YTCHVQHKGL PEPLTLRWEP SSQSTIPIVG IVAGLAVVAV VVTGAVVAAV MWRRKSSGAK GGSYSQAASS DSAQGSDVSL TA // ID A4FUM4_DANRE Unreviewed; 364 AA. AC A4FUM4; DT 17-APR-2007, integrated into UniProtKB/TrEMBL. DT 17-APR-2007, sequence version 1. DT 12-SEP-2018, entry version 107. DE SubName: Full=MHC class I antigen ZCA transcript variant 1 {ECO:0000313|EMBL:AHA37375.1}; DE SubName: Full=Major histocompatibility complex class I ZCA {ECO:0000313|Ensembl:ENSDARP00000063528}; DE SubName: Full=Zgc:136614 protein {ECO:0000313|EMBL:AAI15197.1}; GN Name=mhc1zca {ECO:0000313|EMBL:AHA37375.1, GN ECO:0000313|Ensembl:ENSDARP00000063528, GN ECO:0000313|ZFIN:ZDB-GENE-070424-4}; GN Synonyms=zgc:136614 {ECO:0000313|EMBL:AAI15197.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI15197.1}; RN [1] {ECO:0000313|EMBL:AAI15197.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Whole {ECO:0000313|EMBL:AAI15197.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSDARP00000063528} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000063528}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSDARP00000063528, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000063528, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [4] {ECO:0000313|EMBL:AHA37375.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24287892; DOI=10.1007/s00251-013-0748-z; RA Dirscherl H., Yoder J.A.; RT "Characterization of the Z lineage Major histocompatability complex RT class I genes in zebrafish."; RL Immunogenetics 66:185-198(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX005416; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC115196; AAI15197.1; -; mRNA. DR EMBL; KC607835; AHA37375.1; -; mRNA. DR RefSeq; NP_001077014.1; NM_001083545.1. DR UniGene; Dr.77541; -. DR STRING; 7955.ENSDARP00000063528; -. DR Ensembl; ENSDART00000063529; ENSDARP00000063528; ENSDARG00000069471. DR GeneID; 556341; -. DR KEGG; dre:556341; -. DR CTD; 556341; -. DR ZFIN; ZDB-GENE-070424-4; mhc1zca. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000253930; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF334519; -. DR Proteomes; UP000000437; Chromosome 1. DR Bgee; ENSDARG00000069471; Expressed in 17 organ(s), highest expression level in muscle tissue. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015285443. FT TRANSMEM 313 336 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 300 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 42247 MW; 3935B25FD3C31042 CRC64; MAVLAVLFSA VMLLSVVSVR TEKHSLYYIY TALSRPVDQS GIYQFTAMGL LDDRQIDYYN NIDQKKIPKQ HWMKEKMQED YWEKGTQSRK SKEQWFNVNV NILMDRMRHN NSDLHVLQWR HGCEIEIQGN EHRFSKGIDE YSYDGRNFLS FDDAESQWVA PVDAALPTKR KWDNVPILNQ YTKGYLEKEC VDWLNKFREY GDQELRDGSP PDVYVFARRI ISGKIKLKLT CMATGFYPKD MILTIRKYRT TLPDNDLDSS GVRPNQDGTF QLRKSTNIYE DEKAEYDCYV NHRTLKEPII VRWNGEYLSE PPIAIIAAII GVLILLVAIG VTVWILKKKN IIGNKDEKRS MPNGSANYGR GSSA // ID A4GE63_PAPAN Unreviewed; 348 AA. AC A4GE63; DT 17-APR-2007, integrated into UniProtKB/TrEMBL. DT 17-APR-2007, sequence version 1. DT 12-SEP-2018, entry version 84. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:ABD38928.1}; DE SubName: Full=MHC class I protein {ECO:0000313|EMBL:SNR17782.1}; DE SubName: Full=Major histocompatibility complex, class I, F precursor {ECO:0000313|Ensembl:ENSPANP00000013898}; GN Name=Paca-F {ECO:0000313|EMBL:ABD38928.1}; GN Synonyms=Paan-F {ECO:0000313|EMBL:SNR17782.1}; OS Papio anubis (Olive baboon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Papio. OX NCBI_TaxID=9555 {ECO:0000313|EMBL:ABD38928.1}; RN [1] {ECO:0000313|EMBL:ABD38928.1} RP NUCLEOTIDE SEQUENCE. RA Gharwan H., Sageshima N., Ishitani A., Geraghty D.E.; RT "A comparative study of the MHC-F expression patterns between humans RT and nonhuman primates."; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPANP00000013898, ECO:0000313|Proteomes:UP000028761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., RA Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., RA Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B., RA Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B., RA Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C., RA Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D., RA Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F., RA Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G., RA Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J., RA Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J., RA Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K., RA Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L., RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L., RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M., RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N., RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O., RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., RA Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., RA Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S., RA Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T., RA Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U., RA Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W., RA Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W., RA Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N., RA Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.; RT "Whole Genome Assembly of Papio anubis."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPANP00000013898} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:SNR17782.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PA936G {ECO:0000313|EMBL:SNR17783.1}, and RC V9929E {ECO:0000313|EMBL:SNR17782.1}; RA Sun Z.S., Albrecht U., Echele G., Lee C.C.; RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHZZ02024338; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DQ367727; ABD38928.1; -; mRNA. DR EMBL; LT899666; SNR17782.1; -; mRNA. DR EMBL; LT899667; SNR17783.1; -; mRNA. DR RefSeq; NP_001106101.1; NM_001112631.1. DR UniGene; Pan.11065; -. DR Ensembl; ENSPANT00000022752; ENSPANP00000013898; ENSPANG00000007708. DR GeneID; 100126713; -. DR CTD; 100126713; -. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR OMA; RITQRFY; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000028761; Chromosome 4. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000028761}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028761}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 348 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015086376. FT TRANSMEM 307 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 348 AA; 39563 MW; C66893D450237BFF CRC64; MAPRTLLLVL SGALALTETW AGSHSLRYFS TAVSRPGRRE PRYRYIAVEY VDDTQFLRFD SDAAIPRMEP RAPWVEQEGP QYWERTTGYA KANARTDRVA LRKLLLRYNQ SEAGSHTLQG MNGCDMGPDG RLLRGYHQHA YDGKDYISLN EDLRSWTAAD TVARITQRFY EADEYAEEFR TYLEGECLEL LRRYLENGKE TLQRADPPKA HVAHHPISDR EATLRCWALG FYPAEITLTW QRDGEEQTQD TELVETRPAG DGTFQKWAAV VVPSGEEQRY TCYVQHEGLP QPLTLRWEPS SQPTIPIVGI VAGLAVLAVV VTGAMVAAVM WRRKSSDRNR GSYSQPTM // ID A6QQ36_BOVIN Unreviewed; 300 AA. AC A6QQ36; F1MGV9; DT 21-AUG-2007, integrated into UniProtKB/TrEMBL. DT 15-JAN-2008, sequence version 2. DT 12-SEP-2018, entry version 72. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:AAI49627.2, ECO:0000313|Ensembl:ENSBTAP00000050046}; GN Name=LOC100850276 {ECO:0000313|Ensembl:ENSBTAP00000050046}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI49627.2}; RN [1] {ECO:0000313|EMBL:AAI49627.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Hereford {ECO:0000313|EMBL:AAI49627.2}; RC TISSUE=Fetal pons {ECO:0000313|EMBL:AAI49627.2}; RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y., RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C., RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J., RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J., RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., RA Siddiqui A., Holt R., Jones S.J., Marra M.A.; RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSBTAP00000050046, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000050046, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [3] {ECO:0000313|Ensembl:ENSBTAP00000050046} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000050046}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02026989; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC149626; AAI49627.2; -; mRNA. DR RefSeq; XP_005211086.1; XM_005211029.3. DR RefSeq; XP_010798103.1; XM_010799801.2. DR STRING; 9913.ENSBTAP00000050046; -. DR Ensembl; ENSBTAT00000055373; ENSBTAP00000050046; ENSBTAG00000038112. DR GeneID; 100850276; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR HOGENOM; HOG000070028; -. DR HOVERGEN; HBG052564; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Reactome; R-BTA-163125; Post-translational modification: synthesis of GPI-anchored proteins. DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000009136; Chromosome 9. DR Bgee; ENSBTAG00000038112; Expressed in 10 organ(s), highest expression level in heart. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 300 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014083986. FT TRANSMEM 226 248 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 26 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 300 AA; 34039 MW; 22717D761B3636F3 CRC64; MGGSKTSLGF LVLLPIVLFS RTSSDAHSLS YNVTIDPRPR DGQPWCEVQG EVDQKVFLSY DCGRAKIMYM SPLGEKVKSM NAWETQTDTL RDIGDLLKEQ MPDVTPEKHI DEVGSGLLTL QARMACWRED NGHTSASWQF GFNGQTCLLF DLENGHWTMV HSKGRRMKEK WENDRAVTEF FKKVSMGDCQ RWFQDFLLRW EKMLKTTASP TTGPSTMQPM APDSSYIAWI ATGVLAGFVM TIIIIACIRY KKRKLCSQEA PDRCSVGLRT QSLLGCFCSP AVYFRAKRSD LRNPKSVYQL // ID A7VMS2_MOUSE Unreviewed; 374 AA. AC A7VMS2; DT 23-OCT-2007, integrated into UniProtKB/TrEMBL. DT 18-MAR-2008, sequence version 2. DT 12-SEP-2018, entry version 108. DE SubName: Full=MHC classIb T15 {ECO:0000313|EMBL:BAF76147.2}; GN Name=Gm11127 {ECO:0000313|Ensembl:ENSMUSP00000109371, GN ECO:0000313|MGI:MGI:3779381}; GN Synonyms=H2-T15 {ECO:0000313|EMBL:BAF76147.2}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAF76147.2}; RN [1] {ECO:0000313|EMBL:BAF76147.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:BAF76147.2}; RC TISSUE=Thymus {ECO:0000313|EMBL:BAF76147.2}; RX PubMed=18416856; DOI=10.1186/1471-2164-9-178; RA Ohtsuka M., Inoko H., Kulski J.K., Yoshimura S.; RT "Major histocompatibility complex (Mhc) class Ib gene duplications, RT organization and expression patterns in mouse strain C57BL/6."; RL BMC Genomics 9:178-178(2008). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000109371, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000109371, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000109371} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000109371}; RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CT030728; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AB359227; BAF76147.2; -; mRNA. DR RefSeq; NP_001186896.1; NM_001199967.1. DR UniGene; Mm.484641; -. DR UniGene; Mm.484916; -. DR STRING; 10090.ENSMUSP00000109371; -. DR Ensembl; ENSMUST00000113742; ENSMUSP00000109371; ENSMUSG00000079492. DR GeneID; 100529082; -. DR KEGG; mmu:100529082; -. DR UCSC; uc008cjz.2; mouse. DR MGI; MGI:3779381; Gm11127. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; LENECIE; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000079492; Expressed in 16 organ(s), highest expression level in colon. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 374 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015086579. FT TRANSMEM 306 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 374 AA; 41894 MW; 6148B31F3DF58BB0 CRC64; MGTLTSCPLL LLLLATALAP TQAGKSSHSL RYFATAISRP GFGEPRFTAV GYVDDTQFMR FDSDSENPRA EPCKPWVEQM EPEYWEQETR KFKEHTQNFR TCLYNLLHLY NQSQDGPHTI QDMHGCYVGP DGQFLHGHYQ HAYDGHDYIT LNEDLSSWTA ADAVAQITQH KWEEAGVAEE YKAYLEGTCV ETLHRLLEEA QQHSDPPNTH VTRHPRPEGD VTLRCWALGF YPADITLTWQ LNGEELTQDM ELVETRPAGD GTFQKWAAVV VPLGKEQNYT CHVHHEGLPE PLTLRWEPLP STDSNMVIIA ALVVFGAVII IGAVVAFMMK RRNTGGKGGV YCWEPRPHSP LQDGADSCVL SGKQIICACA KGIL // ID A7VMS3_MOUSE Unreviewed; 348 AA. AC A7VMS3; DT 23-OCT-2007, integrated into UniProtKB/TrEMBL. DT 23-OCT-2007, sequence version 1. DT 12-SEP-2018, entry version 103. DE SubName: Full=Histocompatibility 2, M region locus 5 {ECO:0000313|Ensembl:ENSMUSP00000131365}; DE SubName: Full=MHC classIb protein M5 {ECO:0000313|EMBL:BAF76148.1}; GN Name=H2-M5 {ECO:0000313|EMBL:BAF76148.1, GN ECO:0000313|Ensembl:ENSMUSP00000131365, ECO:0000313|MGI:MGI:95917}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAF76148.1}; RN [1] {ECO:0000313|EMBL:BAF76148.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:BAF76148.1}; RX PubMed=18416856; DOI=10.1186/1471-2164-9-178; RA Ohtsuka M., Inoko H., Kulski J.K., Yoshimura S.; RT "Major histocompatibility complex (Mhc) class Ib gene duplications, RT organization and expression patterns in mouse strain C57BL/6."; RL BMC Genomics 9:178-178(2008). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000131365, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000131365, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000131365} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000131365}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR956641; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AB359228; BAF76148.1; -; mRNA. DR RefSeq; NP_001108547.1; NM_001115075.1. DR UniGene; Mm.246609; -. DR STRING; 10090.ENSMUSP00000131365; -. DR Ensembl; ENSMUST00000169189; ENSMUSP00000131365; ENSMUSG00000024459. DR GeneID; 240095; -. DR KEGG; mmu:240095; -. DR UCSC; uc008clt.1; mouse. DR CTD; 240095; -. DR MGI; MGI:95917; H2-M5. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; RMFGCEI; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000024459; Expressed in 21 organ(s), highest expression level in bone marrow. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 348 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015086582. FT TRANSMEM 308 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 348 AA; 39478 MW; 5C94A264BF0C5A1C CRC64; MRSPALSTLL SLLLTGALAL TLVRAGIHSL QFFATTMTQP GLREHSFIFV VFVDDTQFLC YNNKGKNQRM EPRALWVKQM GPEYWEQQTR TVKVIEKIAL VNLQEAMDIY NHSKDGSHVF QCVYGCEVGP DGLFLRGHEK HAYDGRDYLT LSPDLHSWVA GDTAAQITLR RWEKSGVSEQ RQSFLKGECV ESLRTYLEIG KETLLRTDPP KAHVTHHPRP EGEVTLRCWA LGFYPANIIL TWQWDEEDLT QDMDLIETRP AGDGTFQKWA SVVVPSGEEQ RYTCHVQHEG LTQPLVLKWD PSKHTIPIMG ITVGLLLFGV VFTGAVVAIV MRKRKGFQII ILKTFLKG // ID A7VMS6_MOUSE Unreviewed; 368 AA. AC A7VMS6; DT 23-OCT-2007, integrated into UniProtKB/TrEMBL. DT 18-MAR-2008, sequence version 2. DT 12-SEP-2018, entry version 107. DE SubName: Full=MHC classIb T5 {ECO:0000313|EMBL:BAF76151.2}; GN Name=Gm8909 {ECO:0000313|Ensembl:ENSMUSP00000036092, GN ECO:0000313|MGI:MGI:3704134}; GN Synonyms=EG667977 {ECO:0000313|MGI:MGI:3704134}, GN H2-T5 {ECO:0000313|EMBL:BAF76151.2}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAF76151.2}; RN [1] {ECO:0000313|EMBL:BAF76151.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:BAF76151.2}; RX PubMed=18416856; DOI=10.1186/1471-2164-9-178; RA Ohtsuka M., Inoko H., Kulski J.K., Yoshimura S.; RT "Major histocompatibility complex (Mhc) class Ib gene duplications, RT organization and expression patterns in mouse strain C57BL/6."; RL BMC Genomics 9:178-178(2008). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000036092, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000036092, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000036092} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000036092}; RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CT030728; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AB359231; BAF76151.2; -; mRNA. DR RefSeq; NP_001074501.2; NM_001081032.2. DR UniGene; Mm.441651; -. DR UniGene; Mm.489198; -. DR STRING; 10090.ENSMUSP00000036092; -. DR Ensembl; ENSMUST00000040467; ENSMUSP00000036092; ENSMUSG00000073402. DR GeneID; 667977; -. DR KEGG; mmu:667977; -. DR UCSC; uc012asn.2; mouse. DR MGI; MGI:3704134; Gm8909. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000073402; Expressed in 17 organ(s), highest expression level in colon. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A7VMS6}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 368 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015086580. FT TRANSMEM 309 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 41642 MW; 97E83F02583AEC9E CRC64; MAPRTLLLLL AAALILTETR AVSRPGPHSM RYFETAVSRP GLGEPWFISV GYVDDTQFVR FDGDAENPRM EPRAPWMEQE GPEYWERETQ IAKGHEQGFQ GSLRNLLHYY NQSAGGSHTF QRMYGCDLGS DGRLLRGYWQ FAYDGSDYIA LNQDLKTWTA ADLAAQITRR RWEQGGVAET LRAYLEDPCL EWLRRYLELG KETLLRTDPP KVHVTHHPRS EDDVTLRCWA LGFYPADITL TWQLNGEELT QDMELVETRP AGDGTFQKWA SVVVPLGKEQ NYTCHVYHEG LPEPLTLRWE PRPSRDSNMV IIAVLVVLGV VIIIGAMVPF VLKSRRKIGG KEENYALAGG SNSVQGSALF LEAFSHPS // ID A7YWH4_BOVIN Unreviewed; 363 AA. AC A7YWH4; DT 23-OCT-2007, integrated into UniProtKB/TrEMBL. DT 23-OCT-2007, sequence version 1. DT 12-SEP-2018, entry version 102. DE SubName: Full=BoLA protein {ECO:0000313|EMBL:AAI34574.1}; GN Name=BoLA {ECO:0000313|EMBL:AAI34574.1, GN ECO:0000313|Ensembl:ENSBTAP00000031125}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI34574.1}; RN [1] {ECO:0000313|EMBL:AAI34574.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=L1 Hereford {ECO:0000313|EMBL:AAI34574.1}; RC TISSUE=Basal ganglia {ECO:0000313|EMBL:AAI34574.1}; RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y., RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C., RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J., RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J., RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., RA Siddiqui A., Holt R., Jones S.J., Marra M.A.; RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSBTAP00000031125, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000031125, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [3] {ECO:0000313|Ensembl:ENSBTAP00000031125} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000031125}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02055385; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC134573; AAI34574.1; -; mRNA. DR RefSeq; NP_001108327.1; NM_001114855.1. DR UniGene; Bt.105269; -. DR UniGene; Bt.88540; -. DR STRING; 9913.ENSBTAP00000031125; -. DR Ensembl; ENSBTAT00000031166; ENSBTAP00000031125; ENSBTAG00000005182. DR GeneID; 533050; -. DR KEGG; bta:533050; -. DR CTD; 505676; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; VPGYYNQ; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000009136; Chromosome 23. DR Bgee; ENSBTAG00000005182; Expressed in 9 organ(s), highest expression level in lung. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 363 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014084108. FT TRANSMEM 307 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 363 AA; 41014 MW; 8CB79C45A21164E8 CRC64; MRVVGQRTLL LLLLLDALIL TETRAGSHSL RYFYTAVSRP GLGEPRFISV GYVDDTQFVR FDSDAPDPRI EPTARWVEQE GPEYWHQETQ RTKDTAQFFR VYLNTLRGYY NQSEAGSHTV QEMYGCDVGP DGLLRGYDQF AYDGRDYIAL NEDLRSWTAA DTAAQVTKHN AEAAGDAARV RIYLEGKCVE WLRRYLVTGK DTLLRADPPK THVAHHPISD REVTLRCWAL GFYPEEISLT WQRDGEDQTQ DMELVETRPS GDGTFQKWAA LVVPSGEEQR YTCHVQHEGL QEPLTLRWEP PQPSIPIMGI IVGLVHLMVT GAMVTGAVIW RKKHSGEKGR IYSQASSSDS DQGSDVPLTV PKV // ID A8E7F2_DANRE Unreviewed; 350 AA. AC A8E7F2; DT 13-NOV-2007, integrated into UniProtKB/TrEMBL. DT 13-NOV-2007, sequence version 1. DT 12-SEP-2018, entry version 96. DE SubName: Full=MHC class I antigen ZEA transcript variant 1 {ECO:0000313|EMBL:AHA37389.1}; DE SubName: Full=Major histocompatibility complex class I ZEA {ECO:0000313|Ensembl:ENSDARP00000091917}; GN Name=mhc1zea {ECO:0000313|EMBL:AHA37389.1, GN ECO:0000313|Ensembl:ENSDARP00000091917, GN ECO:0000313|ZFIN:ZDB-GENE-070705-176}; GN Synonyms=si:ch211-287j19.6 {ECO:0000313|ZFIN:ZDB-GENE-070705-176}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000091917, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000091917, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000091917, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [2] {ECO:0000313|Ensembl:ENSDARP00000091917} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000091917}; RG Ensembl; RL Submitted (FEB-2013) to UniProtKB. RN [3] {ECO:0000313|EMBL:AHA37389.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24287892; DOI=10.1007/s00251-013-0748-z; RA Dirscherl H., Yoder J.A.; RT "Characterization of the Z lineage Major histocompatability complex RT class I genes in zebrafish."; RL Immunogenetics 66:185-198(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX005416; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC607850; AHA37389.1; -; mRNA. DR RefSeq; XP_005171057.1; XM_005171000.3. DR UniGene; Dr.77541; -. DR STRING; 7955.ENSDARP00000091917; -. DR Ensembl; ENSDART00000101143; ENSDARP00000091917; ENSDARG00000001470. DR GeneID; 565708; -. DR CTD; 565708; -. DR ZFIN; ZDB-GENE-070705-176; mhc1zea. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000253930; -. DR HOVERGEN; HBG016709; -. DR OMA; SCEVIHE; -. DR TreeFam; TF334519; -. DR Proteomes; UP000000437; Chromosome 1. DR Bgee; ENSDARG00000001470; Expressed in 16 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 350 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015285671. FT TRANSMEM 318 340 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 212 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 350 AA; 40502 MW; 793F226797E64A60 CRC64; MAVFAALFSV VMLFTVVPAW TEKHSLYYIY TALSRPVHLP GIYEFTAMGL LDDRQIDYYN SQEQKKIPKQ HWMKEKMQED YWEKGTQSRK SKEQWFNVNL KILMERMRHN NNSDVHVLQW RHGCEIDSQG NDVRFSKGID EYSYDGRNFL AFDDADSQWV APVEEALPTK RKWDNVPILN QYTKGYLEKE CVDWLNKFRE YGDQELREGS PPDVHVFAKK IISGKAKLKL TCMVTGFYPK DVILTIRKYR TALSDNEVES SGVRPNPDGT FQLRKSTNIY EKAEYDCYVA HRTLKEPIIK KWDGECQDCS SGTPIGTIFG ALIGVLLVLA VIGGAVYFLA NTRMGWRNAL // ID A8E7F4_DANRE Unreviewed; 398 AA. AC A8E7F4; DT 13-NOV-2007, integrated into UniProtKB/TrEMBL. DT 13-NOV-2007, sequence version 1. DT 12-SEP-2018, entry version 105. DE SubName: Full=MHC class I antigen ZBA transcript variant 1 {ECO:0000313|EMBL:AHA37371.1}; DE SubName: Full=Major histocompatibility complex class I ZBA {ECO:0000313|Ensembl:ENSDARP00000053152}; DE SubName: Full=Zgc:64115 protein {ECO:0000313|EMBL:AAI54331.1}; GN Name=mhc1zba {ECO:0000313|EMBL:AHA37371.1, GN ECO:0000313|Ensembl:ENSDARP00000053152, GN ECO:0000313|ZFIN:ZDB-GENE-040426-2149}; GN Synonyms=mhc1zha {ECO:0000313|ZFIN:ZDB-GENE-040426-2149}; GN ORFNames=zgc:64115 {ECO:0000313|EMBL:AAI54331.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000053152, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|EMBL:AAI54331.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Whole {ECO:0000313|EMBL:AAI54331.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSDARP00000053152, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000053152, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [3] {ECO:0000313|Ensembl:ENSDARP00000053152} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000053152}; RG Ensembl; RL Submitted (FEB-2013) to UniProtKB. RN [4] {ECO:0000313|EMBL:AHA37371.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24287892; DOI=10.1007/s00251-013-0748-z; RA Dirscherl H., Yoder J.A.; RT "Characterization of the Z lineage Major histocompatability complex RT class I genes in zebrafish."; RL Immunogenetics 66:185-198(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX005416; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC154330; AAI54331.1; -; mRNA. DR EMBL; KC607831; AHA37371.1; -; mRNA. DR RefSeq; NP_001103588.1; NM_001110118.1. DR UniGene; Dr.77541; -. DR STRING; 7955.ENSDARP00000053152; -. DR Ensembl; ENSDART00000053153; ENSDARP00000053152; ENSDARG00000036588. DR GeneID; 791453; -. DR KEGG; dre:791453; -. DR CTD; 791453; -. DR ZFIN; ZDB-GENE-040426-2149; mhc1zba. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000253930; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G0BBK; -. DR TreeFam; TF334519; -. DR Proteomes; UP000000437; Chromosome 1. DR Bgee; ENSDARG00000036588; Expressed in 25 organ(s), highest expression level in pharyngeal gill. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 398 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015285683. FT TRANSMEM 317 341 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 300 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 398 AA; 45327 MW; 4DC312443A9FC4F7 CRC64; MGSFAVLFSA VMLVAVVPAW TEKHSLYYIY TALSRPVNLP GIYEFTAMGL LDDRQIDYYN SEQQKKIPKQ HWMKEKMQED YWEKGTQSRK SKEQWFNVNV NILMERMRHN KSDVHVLQWR HGCEIESQGN DVRFSRGIDE YSYDGRNFLS FDDAESQWVA PVEEALPTKR KWDNVPILNQ YTKGYLEKEC VDWLNKFREY GDKELREGSS PEVHVFAKRI INGKIKLKLT CLATGFYPKD VILNIRKYRI TLPDNEVEST GVRPNEDGTF QLRKSINIYE DEKAEYDCYV SHTTLKEPII KKWDGECLDG PESGSPIGII AGAIIVVLVV LAAIGGAVYF LRKRSGNNNV KPSSVPTISG NKDEKCSMLP GSDDSGQGSS DGSSKSSPTN SQEKMDIV // ID B0UXQ0_HUMAN Unreviewed; 365 AA. AC B0UXQ0; A0A0D6K955; DT 08-APR-2008, integrated into UniProtKB/TrEMBL. DT 08-APR-2008, sequence version 1. DT 12-SEP-2018, entry version 106. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000450169}; DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:CAQ16345.1, ECO:0000313|EMBL:CDO33932.1}; GN Name=HLA-A {ECO:0000313|EMBL:CAQ16345.1, GN ECO:0000313|Ensembl:ENSP00000450169}; GN Synonyms=HLA {ECO:0000313|EMBL:ASU50344.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAQ16345.1}; RN [1] {ECO:0000313|Ensembl:ENSP00000450169, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|EMBL:CAQ16345.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Peripheral blood {ECO:0000313|EMBL:CAQ16345.1}; RA Heinold A., Schaller-Suefling E., Opelz G., Scherer S., Tran T.H.; RT "Identification of two novel HLA alleles, HLA-A*02010103 and HLA- RT B*4455, and characterization of the complete genomic sequence of HLA- RT A*290201."; RL Tissue Antigens 72:397-400(2008). RN [3] {ECO:0000313|EMBL:CAQ16345.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Peripheral blood {ECO:0000313|EMBL:CAQ16345.1}; RA Tran H.; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] {ECO:0000313|EMBL:ADQ48108.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=21859426; DOI=10.1111/j.1399-0039.2011.01752.x; RA Xu Y., Li Z., Zou H., Deng Z.; RT "Two novel HLA-A alleles, A*29:02:01:02 and A*68:01:01:02, were RT identified by genomic full-length cloning and sequencing."; RL Tissue Antigens 79:72-74(2012). RN [6] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [7] {ECO:0000313|EMBL:CDO33932.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Peripheral blood {ECO:0000313|EMBL:CDO33932.1}; RA McWhinnie A.J., Robinson J.; RT "Confirmatory sequencing of HLA-A*29:02:01:02."; RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:CEG62396.1} RP NUCLEOTIDE SEQUENCE. RA Voorter C.; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:CEG62396.1} RP NUCLEOTIDE SEQUENCE. RA Gerritsen K.E.H., Olieslagers T.I., Groeneweg M., Voorter C.E.M., RA Tilanus M.G.J.; RT "An improved and validated RNA HLA class I SBT approach for obtaining RT full length coding sequences."; RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [11] {ECO:0000313|Ensembl:ENSP00000450169} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. RN [12] {ECO:0000313|EMBL:CRX74685.1} RP NUCLEOTIDE SEQUENCE. RA Hoefler B.C., Straight P.D.; RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:CTQ48004.1} RP NUCLEOTIDE SEQUENCE. RA Tran T., Druce J.; RT "MeaNS - Measles Nucleotide Surveillance Program."; RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:CUA55064.1} RP NUCLEOTIDE SEQUENCE. RA Noorani M.; RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:CRX74685.1} RP NUCLEOTIDE SEQUENCE. RA Rikkerink E.H.A., Fineran P.C.; RT "Complete DNA Sequence of Pseudomonas syringae pv. actinidiae, the RT Causal Agent of Kiwifruit Canker Disease."; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:SBV08748.1} RP NUCLEOTIDE SEQUENCE. RA Lavstsen T., Jespersen J.S.; RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:CUA55064.1} RP NUCLEOTIDE SEQUENCE. RA Marsh S.G.E.; RT "Full-length genomic HLA sequences."; RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:CQR91464.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=28547825; DOI=.1111/tan.13057; RA Albrecht V., Zweiniger C., Surendranath V., Lang K., Schofl G., RA Dahl A., Winkler S., Lange V., Bohme I., Schmidt A.H.; RT "Dual redundant sequencing strategy: Full-length gene characterisation RT of 1056 novel and confirmatory HLA alleles."; RL HLA. 90:79-87(2017). RN [19] {ECO:0000313|EMBL:ASU50344.1} RP NUCLEOTIDE SEQUENCE. RA Balz V., Krause S., Enczmann J., Fischer J.; RT "More than 130 novel variants of HLA class 1 genes detected in German RT Stem Cell Donor Registry and Terasaki samples."; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|EMBL:SMB18742.1} RP NUCLEOTIDE SEQUENCE. RA Masson D., Colom S.; RT "x."; RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0000313|EMBL:AWB14529.1} RP NUCLEOTIDE SEQUENCE. RA Yin Y., Takemura P., Bolon Y.-T., Springer B., Saito K., Reed E.F., RA Zhang Q.J.; RT "Advances in HLA clinical relevant exon novelty detection from over RT 21,000 donor recruitment samples."; RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases. RN [22] {ECO:0000313|EMBL:SNQ25991.1} RP NUCLEOTIDE SEQUENCE. RA Kim H.J., Triplett B.A.; RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases. RN [23] {ECO:0000313|EMBL:SBV08748.1} RP NUCLEOTIDE SEQUENCE. RA Marsh S.G.E.; RT "Full-length genomic HLA sequences."; RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases. RN [24] {ECO:0000313|EMBL:ASU61678.1} RP NUCLEOTIDE SEQUENCE. RA Sun Z.S., Albrecht U., Echele G., Lee C.C.; RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases. RN [25] {ECO:0000313|EMBL:SNQ25991.1} RP NUCLEOTIDE SEQUENCE. RA Groeneweg M., Matern B., Palusci F., Meertens C., Tilanus M.G.J., RA Voorter C.E.M.; RT "Group specific, unambiguous full-length gene HLA Class I typing by RT Sanger sequencing: a robust SSBT Strategy for typing and a golden RT reference for next generation sequencing approaches."; RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases. RN [26] {ECO:0000313|EMBL:AUD08728.1} RP NUCLEOTIDE SEQUENCE. RA Lazaro A.M., Hou L., Enriquez E., Persaud M., Hurley C.K.; RT "Novel HLA Class I alleles."; RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases. RN [27] {ECO:0000313|EMBL:AUQ33054.1} RP NUCLEOTIDE SEQUENCE. RA Cereb N., Yang S.Y.; RT "HLA new alleles found by Histogenetics."; RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases. RN [28] {ECO:0000313|EMBL:ASA47552.1} RP NUCLEOTIDE SEQUENCE. RA Hurley C.K., Hou L., Lazaro A., Gerfen J., Enriquez E., Galarza P., RA Rodriguez Cardozo M.B., Halagan M., Maiers M., Behm D., Ng J.; RT "Next generation sequencing characterizes the extent of HLA diversity RT in an Argentinian registry population."; RL HLA. 91:175-186(2018). RN [29] {ECO:0000313|EMBL:AUQ33054.1} RP NUCLEOTIDE SEQUENCE. RA Marsh S.G.E.; RT "Nomenclature for factors of the HLA system, update December 2017."; RL Int. J. Immunogenet. 0:0-0(2018). RN [30] {ECO:0000313|EMBL:SOX30067.1} RP NUCLEOTIDE SEQUENCE. RA Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [31] {ECO:0000313|EMBL:SPQ44332.1} RP NUCLEOTIDE SEQUENCE. RA Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., RA Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Rusch D., RA Podicherti R., Tsui H.-C.T., Winkler M.E.; RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR382333; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; HM595424; ADQ48108.1; -; Genomic_DNA. DR EMBL; KY350869; ASA47552.1; -; Genomic_DNA. DR EMBL; KY762290; ASG91926.1; -; Genomic_DNA. DR EMBL; KY419453; ASU50344.1; -; Genomic_DNA. DR EMBL; MF474228; ASU61678.1; -; Genomic_DNA. DR EMBL; MG189581; AUD08728.1; -; Genomic_DNA. DR EMBL; MG450945; AUQ33054.1; -; Genomic_DNA. DR EMBL; MF069203; AWB14529.1; -; Genomic_DNA. DR EMBL; AM944568; CAQ16345.1; -; Genomic_DNA. DR EMBL; HG965144; CDO33932.1; -; Genomic_DNA. DR EMBL; LN623521; CEG62396.1; -; mRNA. DR EMBL; LN832586; CQR91464.2; -; Genomic_DNA. DR EMBL; LN868254; CRX74685.1; -; Genomic_DNA. DR EMBL; LN873234; CTQ48004.1; -; Genomic_DNA. DR EMBL; LN877321; CUA55064.1; -; Genomic_DNA. DR EMBL; LN877349; CUA55092.1; -; Genomic_DNA. DR EMBL; LN880521; CUI25654.1; -; Genomic_DNA. DR EMBL; LN999579; CUX90972.1; -; Genomic_DNA. DR EMBL; LN999622; CUX91015.1; -; Genomic_DNA. DR EMBL; LT596644; SBV08748.1; -; Genomic_DNA. DR EMBL; LT599182; SBW38403.1; -; Genomic_DNA. DR EMBL; LT599194; SBW38415.1; -; Genomic_DNA. DR EMBL; LT838207; SMB18742.1; -; Genomic_DNA. DR EMBL; LT838208; SMB18743.1; -; Genomic_DNA. DR EMBL; LT898181; SNQ25991.1; -; Genomic_DNA. DR EMBL; LT972151; SOX30067.1; -; Genomic_DNA. DR EMBL; LS398203; SPQ44332.1; -; Genomic_DNA. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR Ensembl; ENST00000550728; ENSP00000450169; ENSG00000231834. DR UCSC; uc011gqx.2; human. DR HGNC; HGNC:4931; HLA-A. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:B0UXQ0, KW ECO:0000213|MaxQB:B0UXQ0, ECO:0000213|PeptideAtlas:B0UXQ0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015087008. FT TRANSMEM 306 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 40841 MW; 4276F0222DE71589 CRC64; MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDLQTRN VKAQSQTDRA NLGTLRGYYN QSEAGSHTIQ MMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV // ID B3F366_SARHA Unreviewed; 361 AA. AC B3F366; DT 22-JUL-2008, integrated into UniProtKB/TrEMBL. DT 22-JUL-2008, sequence version 1. DT 20-JUN-2018, entry version 67. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:ABV58864.1}; GN Name=Saha-I {ECO:0000313|EMBL:ABV58864.1}; GN Synonyms=SAHAI-12 {ECO:0000313|Ensembl:ENSSHAP00000012590}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|EMBL:ABV58864.1}; RN [1] {ECO:0000313|EMBL:ABV58864.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=17673996; DOI=10.1007/s00251-007-0238-2; RA Siddle H.V., Sanderson C., Belov K.; RT "Characterization of major histocompatibility complex class I and RT class II genes from the Tasmanian devil (Sarcophilus harrisii)."; RL Immunogenetics 59:753-760(2007). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000012590} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [3] {ECO:0000313|Ensembl:ENSSHAP00000012590} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01166366; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; EF591099; ABV58864.1; -; mRNA. DR EMBL; EF591100; ABV58865.1; -; mRNA. DR Ensembl; ENSSHAT00000012694; ENSSHAP00000012590; ENSSHAG00000010776. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 361 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015087262. FT TRANSMEM 307 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 161 188 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 361 AA; 40325 MW; EC749C52E046F99F CRC64; MGSYACSLFL LGALALKETW EGSHSLRYFG TTVSRPGLGE PRFFSVGYVD DQQFVGFDSD SASQRVEPRA PWIEKMENVD RDYWERNTQN SKRNAQISRE DLQTLHGYYN QSESGVHTFQ RLVGCEISPD LSFKRGFDQY AYDGQDYLAL DTETLTWTAA VNEAVNSKHK LEAERSNAER DKAYLEETCV LWLKMYLEMG KESLQRADPP SVQVTRHSTS NGEVTLQCRA QDFYPAEISL TWLRDGEEQH QDTEFIETRP AGDGTFQKWA AVGVTSGQEG KYTCRVQHEG LPEPLILKWE PESSSPWIIV GILAVAVFLL TVVIAGAVVW RKKTSGGKGG DYVLAAGSDS AQGSDVSLSA K // ID B7U1D5_BOVIN Unreviewed; 249 AA. AC B7U1D5; DT 10-FEB-2009, integrated into UniProtKB/TrEMBL. DT 10-FEB-2009, sequence version 1. DT 12-SEP-2018, entry version 71. DE SubName: Full=Major histocompatibility complex class I-related gene protein {ECO:0000313|Ensembl:ENSBTAP00000056442}; DE SubName: Full=Major histocompatibility complex class I-related protein variant 900 {ECO:0000313|EMBL:ACJ60634.1}; GN Name=MR1 {ECO:0000313|EMBL:ACJ60634.1, GN ECO:0000313|Ensembl:ENSBTAP00000056442, ECO:0000313|VGNC:VGNC:31595}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|EMBL:ACJ60634.1}; RN [1] {ECO:0000313|EMBL:ACJ60634.1} RP NUCLEOTIDE SEQUENCE. RA van Rhijn I., Goldfinch N.G.; RT "Ruminant MR1 and MAIT cells - abundance of MAIT cells in spleen in RT the absence of MR1 protein expression."; RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSBTAP00000056442, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056442, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [3] {ECO:0000313|Ensembl:ENSBTAP00000056442} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056442}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02043522; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02043523; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; FJ423041; ACJ60634.1; -; mRNA. DR UniGene; Bt.63045; -. DR Ensembl; ENSBTAT00000064417; ENSBTAP00000056442; ENSBTAG00000009924. DR VGNC; VGNC:31595; MR1. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000009136; Chromosome 16. DR Bgee; ENSBTAG00000009924; Expressed in 10 organ(s), highest expression level in spleen. DR ExpressionAtlas; B7U1D5; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 249 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014085653. FT TRANSMEM 207 231 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 113 208 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 249 AA; 28625 MW; A0A4A0A3648276F9 CRC64; MMLLLPLIIV LMMKLSDARF HTYQRMIGCE LLEDGSITGF LQYAYDGQDF LIFNKDTLSW MAMDNVADII RRVWEANRHE LQYQKNWLEE ECIAWLKRFL EYGKDALQRT EPPKVRVNHK ETFPGITTLY CRAYGFYPPE ISINWMKNGE EIFQDTDYGG ILPSGDGTYQ TWVSVELDPQ NGDIYSCHVE HGGVHMVLQG FQESETILLV VKAVGFIVLA IALAGVGILA WRKRPRGKNK VICLSTPEH // ID B8JM90_DANRE Unreviewed; 359 AA. AC B8JM90; DT 03-MAR-2009, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 1. DT 12-SEP-2018, entry version 72. DE SubName: Full=Major histocompatibility complex class I LAA {ECO:0000313|Ensembl:ENSDARP00000123111}; GN Name=mhc1laa {ECO:0000313|Ensembl:ENSDARP00000123111, GN ECO:0000313|ZFIN:ZDB-GENE-050417-464}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000123111, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000123111, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000123111, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [2] {ECO:0000313|Ensembl:ENSDARP00000123111} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000123111}; RG Ensembl; RL Submitted (AUG-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CU571323; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_017212818.1; XM_017357329.1. DR ProteinModelPortal; B8JM90; -. DR PaxDb; B8JM90; -. DR Ensembl; ENSDART00000143807; ENSDARP00000123111; ENSDARG00000016056. DR ZFIN; ZDB-GENE-050417-464; mhc1laa. DR eggNOG; ENOG410KG2Z; Eukaryota. DR eggNOG; ENOG4110SQP; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000170186; -. DR HOVERGEN; HBG054334; -. DR InParanoid; B8JM90; -. DR OMA; CHIDHAS; -. DR OrthoDB; EOG091G0B7M; -. DR PhylomeDB; B8JM90; -. DR TreeFam; TF334460; -. DR Reactome; R-DRE-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000000437; Chromosome 8. DR Bgee; ENSDARG00000016056; Expressed in 27 organ(s), highest expression level in female gonad. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 359 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002872905. FT TRANSMEM 306 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 41302 MW; FE033C01D1DD4C17 CRC64; MFLRMFCFVC LLPFIGVVNA GSHSLMALAT YIVGQTPFPE FSVVVMLDDL QLAYYDSIGW KTIYRSGSDS KYYDEEQSDA GIVFRDMFYD MKDRAFYLKD HQNHTDGVHV HQRLVGCELL NNEKTGPLHY WDAFGGQNME EFIFDTEKHT IQVKMPWVIT WDQLKRLHEN FMYDNVYHPI CIKTLRRYLN MEKKNVMRKV KPRVRLMQKK LSDSQGLQIS CLATGFYPRH INLTLFRDAE LVDDDQITGG EILPNGDGTY QMRKSLIVSE EELQKGHKYN CTANYLNLDN KMDIVFDVAE SDPGSFSVSV VMGVLVFVGL SVLSITALIM RRKRRDTGSV SGTSQNQYVY AQTSVQDAT // ID C9JAK3_HUMAN Unreviewed; 221 AA. AC C9JAK3; DT 03-NOV-2009, integrated into UniProtKB/TrEMBL. DT 03-NOV-2009, sequence version 1. DT 12-SEP-2018, entry version 52. DE SubName: Full=UL-16-binding protein 5 {ECO:0000313|Ensembl:ENSP00000417503}; GN Name=RAET1G {ECO:0000313|Ensembl:ENSP00000417503}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000417503, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000417503, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000417503} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL583835; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; C9JAK3; -. DR SMR; C9JAK3; -. DR MaxQB; C9JAK3; -. DR PeptideAtlas; C9JAK3; -. DR PRIDE; C9JAK3; -. DR Ensembl; ENST00000479265; ENSP00000417503; ENSG00000203722. DR UCSC; uc063sfu.1; human. DR EuPathDB; HostDB:ENSG00000203722.7; -. DR HGNC; HGNC:16795; RAET1G. DR OpenTargets; ENSG00000203722; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR HOGENOM; HOG000070028; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000203722; Expressed in 81 organ(s), highest expression level in esophagus mucosa. DR ExpressionAtlas; C9JAK3; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|PeptideAtlas:C9JAK3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 221 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002996416. FT DOMAIN 30 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 221 AA; 24922 MW; AD9BFDB3787D46D5 CRC64; MAAAASPAFL LRLPLLLLLS SWCRTGLADP HSLCYDITVI PKFRPGPRWC AVQGQVDEKT FLHYDCGSKT VTPVSPLGKK LNVTTAWKAQ NPVLREVVDI LTEQLLDIQL ENYIPKEPLT LQARMSCEQK AEGHGSGSWQ LSFDGQIFLL FDSENRMWTT VHPGARKMKE KWENDKDMTM SFHYISMGDC TGWLEDFLMG MDSTLEPSAG GNRRKRNGDL Q // ID C9JEV0_HUMAN Unreviewed; 227 AA. AC C9JEV0; DT 03-NOV-2009, integrated into UniProtKB/TrEMBL. DT 03-NOV-2009, sequence version 1. DT 12-SEP-2018, entry version 61. DE SubName: Full=Zinc-alpha-2-glycoprotein {ECO:0000313|Ensembl:ENSP00000396093}; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSP00000396093}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000396093, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000396093, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., RA Waterston R.H., Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000396093} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC004522; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; C9JEV0; -. DR SMR; C9JEV0; -. DR MaxQB; C9JEV0; -. DR PeptideAtlas; C9JEV0; -. DR PRIDE; C9JEV0; -. DR Ensembl; ENST00000411734; ENSP00000396093; ENSG00000160862. DR UCSC; uc064fxv.1; human. DR EuPathDB; HostDB:ENSG00000160862.12; -. DR HGNC; HGNC:910; AZGP1. DR OpenTargets; ENSG00000160862; -. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR ChiTaRS; AZGP1; human. DR Proteomes; UP000005640; Chromosome 7. DR Bgee; ENSG00000160862; Expressed in 195 organ(s), highest expression level in minor salivary gland. DR ExpressionAtlas; C9JEV0; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:C9JEV0, KW ECO:0000213|PeptideAtlas:C9JEV0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 227 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002996546. FT DOMAIN 23 198 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 227 AA; 26354 MW; ACA64485FA042F16 CRC64; MVPVLLSLLL LLGPAVPQEN QDGRYSLTYI YTGLSKHVED VPAFQALGSL NDLQFFRYNS KDRKSQPMGL WRQVEGMEDW KQDSQLQKAR EDIFMETLKD IVEYYNDSNG SHVLQGRFGC EIENNRSSGA FWKYYYDGKD YIEFNKEIPA WVPFDPAAQI TKQKWEAEPV YVQRAKAYLE EECPATLRKY LKYSKNILDR QGTHCFLLPS TEPRIKDDLR LGAQATS // ID D0EV57_HUMAN Unreviewed; 346 AA. AC D0EV57; DT 24-NOV-2009, integrated into UniProtKB/TrEMBL. DT 24-NOV-2009, sequence version 1. DT 18-JUL-2018, entry version 72. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000345828}; DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:ACX50639.1}; GN Name=HLA-F {ECO:0000313|EMBL:ACX50639.1, GN ECO:0000313|Ensembl:ENSP00000345828}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ACX50639.1}; RN [1] {ECO:0000313|Ensembl:ENSP00000345828, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|EMBL:ACX50639.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=PBMC {ECO:0000313|EMBL:ACX50639.1}; RA Wallace L.T., Rudersdorf R., Watkins D.I.; RT "The MHC class I alleles of Homo sapiens."; RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSP00000345828} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL669813; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL844851; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX005428; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX927250; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR753818; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; GQ891552; ACX50639.1; -; mRNA. DR UniGene; Hs.519972; -. DR MaxQB; D0EV57; -. DR PRIDE; D0EV57; -. DR Ensembl; ENST00000342322; ENSP00000345828; ENSG00000137403. DR Ensembl; ENST00000383626; ENSP00000373121; ENSG00000206509. DR Ensembl; ENST00000422711; ENSP00000395853; ENSG00000235220. DR Ensembl; ENST00000435058; ENSP00000408540; ENSG00000237508. DR Ensembl; ENST00000444891; ENSP00000402853; ENSG00000229698. DR Ensembl; ENST00000549422; ENSP00000450119; ENSG00000229698. DR Ensembl; ENST00000550932; ENSP00000450300; ENSG00000206509. DR Ensembl; ENST00000551780; ENSP00000447401; ENSG00000237508. DR Ensembl; ENST00000551832; ENSP00000448260; ENSG00000235220. DR Ensembl; ENST00000552082; ENSP00000447228; ENSG00000137403. DR UCSC; uc011evc.3; human. DR HGNC; HGNC:4963; HLA-F. DR eggNOG; ENOG410IUXN; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR ChiTaRS; HLA-F; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:D0EV57, KW ECO:0000213|PeptideAtlas:D0EV57}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 346 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014569676. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 284 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 346 AA; 39052 MW; D4782AA4697D57B2 CRC64; MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL QRADPPKAHV AHHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPQP LILRWEQSPQ PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAV // ID D3ZKH0_RAT Unreviewed; 349 AA. AC D3ZKH0; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 3. DT 12-SEP-2018, entry version 68. DE SubName: Full=Class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like {ECO:0000313|Ensembl:ENSRNOP00000039605}; GN Name=LOC103690108 {ECO:0000313|Ensembl:ENSRNOP00000039605}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000039605, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000039605, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000039605, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000039605} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000039605}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044383; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; D3ZKH0; -. DR Ensembl; ENSRNOT00000049540; ENSRNOP00000039605; ENSRNOG00000047706. DR RGD; 9113230; LOC103690108. DR GeneTree; ENSGT00760000118960; -. DR OMA; WMEREGR; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000047706; Expressed in 9 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; D3ZKH0; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:D3ZKH0}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 349 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003052869. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 222 283 IGc1. {ECO:0000259|SMART:SM00407}. SQ SEQUENCE 349 AA; 39144 MW; 417AB579D259CD50 CRC64; MGAMAPRTLL LLLAAALAPT QTRAGSHSLR YFVTAISGPG LGEPRFMEVG YVDGTEFVRY DSDAKNPGME PRARWMEREG REYWERETRR VKENEQLFRG NLRTLLGYYN QSEGGSHTIQ WMSGCDVGSD GSLLRGYDQF AYDGRDYIVL NEDLKTWTAA DTAARITRNK WDRAGVAERH KAYLEGKCLE SLLRYLELGK ETLLRSDPPK AHVTLHPRPE GDVTLRCWAL GFYPAGISLT WQLNGEDLTQ DMELVETRPA GDGTFQKWDP ELVRAESWGH DPHLHFLYLS FPEPSPSTDS NMETYVIYVI LGAVAIIAAV IIVAVVAVVM KRRRNTGGKV GVYAPAPSK // ID D3ZKI0_RAT Unreviewed; 265 AA. AC D3ZKI0; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 3. DT 12-SEP-2018, entry version 70. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSRNOP00000041900}; DE Flags: Fragment; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000041900, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000041900, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000041900, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000213|PubMed:16641100} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=16641100; DOI=10.1073/pnas.0600895103; RA Hoffert J.D., Pisitkun T., Wang G., Shen R.F., Knepper M.A.; RT "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: RT regulation of aquaporin-2 phosphorylation at two sites."; RL Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006). RN [3] {ECO:0000313|Ensembl:ENSRNOP00000041900} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000041900}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044383; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044384; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; D3ZKI0; -. DR PRIDE; D3ZKI0; -. DR Ensembl; ENSRNOT00000044520; ENSRNOP00000041900; ENSRNOG00000059770. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000059770; Expressed in 9 organ(s), highest expression level in liver. DR ExpressionAtlas; D3ZKI0; baseline and differential. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 265 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003052680. FT DOMAIN 206 265 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 265 265 {ECO:0000313|Ensembl:ENSRNOP00000041900}. SQ SEQUENCE 265 AA; 30491 MW; A9431F61A6C40026 CRC64; MAPRTLLLLL AAALAPTQTQ AGSHSLRYFD IAVSRPGLGE PRFIIVGYVD DREVMRFDSD AENPRMKPRA RWMEREGPEY WERQTRKVKE KEQIFRDNLR TLLRYYNQSE GGSHTVQRLS GCDVGSDGSL LRGYNQHAYD GRDYIALNED LKTWTAADTA AQITKNKWER DGEAERRRAY LEGECVEWLR SYLAPRKETL LRSDPPKAHV TLHPRPEGDV TLRCWALGFY PAGISLTWQL NGEDLTQDME LVETRPAGDG TFQKW // ID D3ZLE6_RAT Unreviewed; 350 AA. AC D3ZLE6; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 3. DT 12-SEP-2018, entry version 72. DE SubName: Full=RT1 class I, CE7 {ECO:0000313|EMBL:AVP72133.1}; DE SubName: Full=RT1 class I, locus CE7 {ECO:0000313|Ensembl:ENSRNOP00000039197}; GN Name=RT1-CE7 {ECO:0000313|EMBL:AVP72133.1, GN ECO:0000313|Ensembl:ENSRNOP00000039197, ECO:0000313|RGD:1595786}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000039197, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000039197, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000039197, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000039197} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000039197}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000313|EMBL:AVP72133.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:AVP72133.1}; RC TISSUE=Spleen {ECO:0000313|EMBL:AVP72133.1}; RX PubMed=29531166; RA Dai K.Z., Ryan J.C., Naper C., Vaage J.T.; RT "Identification of MHC Class Ib Ligands for Stimulatory and Inhibitory RT Ly49 Receptors and Induction of Potent NK Cell Alloresponses in RT Rats."; RL J. Immunol. 200:2847-2859(2018). RN [4] {ECO:0000313|EMBL:AVP72133.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:AVP72133.1}; RC TISSUE=Spleen {ECO:0000313|EMBL:AVP72133.1}; RA Cohen D.B., Kent A.D.; RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044398; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044399; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044400; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044401; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044402; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044403; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044404; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044405; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044406; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044407; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; MG963103; AVP72133.1; -; mRNA. DR UniGene; Rn.234338; -. DR STRING; 10116.ENSRNOP00000039197; -. DR PaxDb; D3ZLE6; -. DR PeptideAtlas; D3ZLE6; -. DR Ensembl; ENSRNOT00000047527; ENSRNOP00000039197; ENSRNOG00000031090. DR RGD; 1595786; RT1-CE7. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; D3ZLE6; -. DR OMA; SALTKTW; -. DR TreeFam; TF336617; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000031090; Expressed in 9 organ(s), highest expression level in spleen. DR ExpressionAtlas; D3ZLE6; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 350 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015088540. FT TRANSMEM 312 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 350 AA; 39347 MW; 0AB96FB067F61EEA CRC64; MGSRAPHTLL LLLAAALART QPRAGSHSLR YFTTALSRPG LGEPRFISVG YVDDTEFVRF DSDAENPRYE PRAPWMEREG LEYWEQQTRR AKGNQQTFQV NLRTALHYYN QSEDRSHTIQ RMYGCDVGSD GSLLRGYEQS AYDGRDYIAL NEDLKTWTAA DVAAQITRNK WDQAGVAERR RAYLEGTCMK WLRRYLEHGK ETLLRSDPPK AHVTLHPRPE GDVTLRCWAL GFYPADITLT WQLNGEDLTQ DMELVETRPA GDGTFQKWAS VVVPPGKEQN YTCRVEHEGL PEPLTLRWEA PPSTDSNMET NVIYVVIGAI SAVAIIGAVL AVVRKKNTGG TGGDYTPAPA // ID D3ZNA5_RAT Unreviewed; 341 AA. AC D3ZNA5; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 3. DT 12-SEP-2018, entry version 68. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSRNOP00000058009}; DE Flags: Fragment; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000058009, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000058009, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000058009, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000058009} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000058009}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044397; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044398; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044399; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044400; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044401; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044402; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044403; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044404; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044405; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 10116.ENSRNOP00000065658; -. DR PaxDb; D3ZNA5; -. DR PeptideAtlas; D3ZNA5; -. DR Ensembl; ENSRNOT00000061297; ENSRNOP00000058009; ENSRNOG00000061639. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G0LFP; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000061639; Expressed in 9 organ(s), highest expression level in colon. DR ExpressionAtlas; D3ZNA5; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 280 306 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 177 265 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSRNOP00000058009}. SQ SEQUENCE 341 AA; 38445 MW; 75B74040594D502B CRC64; VTAVSRPGLG EPRFISVGYV DDTEFVHYDS DEENPRMEPR TRWVEREGPE YWEEETQRAK RREQWYQGSL RNLRSYYNQS EDGSHTFQKM YGCDVGSDGS LLRGYVQFAY DGRDYIALNE DLKTWMAADT AAQMTRSKWD QAAEAERKRA YLEGECVEGL RRYLELGKET LLRSDPPKAH VTLHPRHEGD VTLRCWALGF YPADITLTWQ LNGEDLTQDM ELVETRPAGD GTFQKWASVV VPSGKEQNYT CHVEHEGLPE PLTLRWESPP STDSNMETNV IYVVVGAISA VAIIAAVIIG ALVCVVRKRW IKTGGKGGDY APALGKDSCQ SSDVSLADCE A // ID D3ZQG9_RAT Unreviewed; 355 AA. AC D3ZQG9; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 3. DT 12-SEP-2018, entry version 70. DE SubName: Full=RT1 class I, locus CE4 {ECO:0000313|Ensembl:ENSRNOP00000041135}; GN Name=RT1-CE4 {ECO:0000313|Ensembl:ENSRNOP00000041135, GN ECO:0000313|RGD:1598234}; Synonyms=RT1-CE2 {ECO:0000313|RGD:1598234}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000041135, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000041135, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000041135, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000041135} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000041135}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044397; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044398; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044399; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044400; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044401; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044402; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044403; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044404; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044405; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044406; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; D3ZQG9; -. DR PRIDE; D3ZQG9; -. DR Ensembl; ENSRNOT00000047779; ENSRNOP00000041135; ENSRNOG00000039744. DR RGD; 1598234; RT1-CE4. DR GeneTree; ENSGT00760000118960; -. DR OMA; FQRMIGC; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000039744; Expressed in 9 organ(s), highest expression level in spleen. DR ExpressionAtlas; D3ZQG9; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 355 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003053636. FT TRANSMEM 315 336 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 355 AA; 40075 MW; 5F4A38178A0CD587 CRC64; MEVMAPRALL LLLAAALALA QTGIGSHSLR YFHTAVSRPG LGEPRFISVG YVDDTEFVRY DSDAENPRYE PRARWMEREG PEYWERQTQI AKRNEQVYRV DLSTLRGYYN QSEGGSHTYQ RMHGCELGSD GSLLRGYMQY AYDGRDYIAL NEDLKTWAAA DVVAQMTRNK WERARYAEKR RANLEGECVE SLRRYLELGK ETLLRSDPPK AHVTLHPRPE GDVTLRCWAL GFYPADITLT WQLNGEDLTQ DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCLVEHEGL PEPLSQRWEP SPSTDSNMGI DVTSVLPGAV AVFVVLAIIG AVVAIVRRRN TGRDSSQSSD VSLRL // ID D4A0E0_RAT Unreviewed; 373 AA. AC D4A0E0; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 3. DT 12-SEP-2018, entry version 73. DE SubName: Full=RT1 class I, locus CE4 {ECO:0000313|Ensembl:ENSRNOP00000059471}; GN Name=RT1-CE4 {ECO:0000313|Ensembl:ENSRNOP00000059471, GN ECO:0000313|RGD:1598234}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000059471, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000059471, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000059471, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000059471} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000059471}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044397; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044398; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044399; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044400; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044401; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044402; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044403; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044404; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044405; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044406; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; D4A0E0; -. DR PRIDE; D4A0E0; -. DR Ensembl; ENSRNOT00000064734; ENSRNOP00000059471; ENSRNOG00000039744. DR RGD; 1598234; RT1-CE4. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; D4A0E0; -. DR OrthoDB; EOG091G0BBK; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000039744; Expressed in 9 organ(s), highest expression level in spleen. DR ExpressionAtlas; D4A0E0; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 373 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003053383. FT TRANSMEM 312 336 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 373 AA; 42279 MW; 30AA722DBE0BF3A1 CRC64; MEVMAPRALL LLLAAALALA QTGIGSHSLR YFETALSRPG FGESRFIIVG YVDDTQFMRF DSDAENPRME PRARWMEREG PGYWEQNTRM AKRQEQWYRV NLRTALRYYN QSEGGSHTYQ RMHGCELGSD GSLLRGYMQY AYDGRDYIAL NEDLKTWMVK DTAARITRNK WDQAGFGERK RTYLQVECLE WLRKYLELGK ETLLRSDPPK VHVTLHPRPE GGVTLRCWAL GFYPADITLT WQLNGEDLTQ DMELVETRPA GDGTFQKWAA VVVPSGEEQK YTCHVEHEGL PEPLTQRWEA PPGTDSNMET NVIYVFFGAV AMIGAVAVIG AVVAVVRRRR RRKRNTGGKG DYAPAPGSDS CQSSDVSLAD CEA // ID D7URV5_MONDO Unreviewed; 343 AA. AC D7URV5; F6RUX9; DT 05-OCT-2010, integrated into UniProtKB/TrEMBL. DT 05-OCT-2010, sequence version 1. DT 12-SEP-2018, entry version 51. DE SubName: Full=MHC class I-like located near the LRC-like {ECO:0000313|EMBL:BAJ11490.1, ECO:0000313|Ensembl:ENSMODP00000000409}; GN Name=MILL-like {ECO:0000313|EMBL:BAJ11490.1, GN ECO:0000313|Ensembl:ENSMODP00000000409}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|EMBL:BAJ11490.1}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000000409, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|EMBL:BAJ11490.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Salivary gland {ECO:0000313|EMBL:BAJ11490.1}; RX PubMed=20376438; DOI=10.1007/s00251-010-0438-z; RA Kondo M., Maruoka T., Otsuka N., Kasamatsu J., Fugo K., Hanzawa N., RA Kasahara M.; RT "Comparative genomic analysis of mammalian NKG2D ligand family genes RT provides insights into their origin and evolution."; RL Immunogenetics 62:441-450(2010). RN [3] {ECO:0000313|Ensembl:ENSMODP00000000409} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AB540179; BAJ11490.1; -; mRNA. DR RefSeq; NP_001180253.1; NM_001193324.1. DR UniGene; Mdm.5196; -. DR Ensembl; ENSMODT00000000418; ENSMODP00000000409; ENSMODG00000000345. DR GeneID; 100499216; -. DR KEGG; mdo:100499216; -. DR CTD; 100499216; -. DR eggNOG; ENOG410J8UC; Eukaryota. DR eggNOG; ENOG4111ECF; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; LVLQSHW; -. DR OrthoDB; EOG091G0VOG; -. DR TreeFam; TF339076; -. DR Proteomes; UP000002280; Chromosome 4. DR Bgee; ENSMODG00000000345; Expressed in 7 organ(s), highest expression level in heart. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT DOMAIN 247 317 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 343 AA; 39437 MW; D2256B08ACF306D7 CRC64; MEGDWRDWRD LCLFFWSKFL RVQECQNSLH RPASCKVQLS QRRFLGIQRA LDSGLHSLQY NFIAISNSDQ ESFSYSALVY LDDQLFLHYG SKSQLELRST SLEVVIPPDI WKKESENLKG MRWKLRATLA KITQQSQEKD GSHTLQVILG CDLLKNGKTR GCLEYGYDGE NFLTFQPETL TWEDYYHPAA NSIKNDFATD LIDTKLNKAK VEQECPQQLQ GYLAVLKEKK ASPSLHVTSK LNNLWVCWAY NIFPGDVKIT WLKDGQALNQ KEQESGILRP SGDGTYQTSV SIYANPKELN YKCHVEHQGK NQTKAIPSGS VRKEFQIIFV NPVVIVIIFN LRE // ID E1B821_BOVIN Unreviewed; 331 AA. AC E1B821; DT 02-NOV-2010, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 12-SEP-2018, entry version 54. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000006320}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000006320, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000006320, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000006320, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000006320} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000006320}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02020107; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E1B821; -. DR STRING; 9913.ENSBTAP00000006320; -. DR PaxDb; E1B821; -. DR Ensembl; ENSBTAT00000006320; ENSBTAP00000006320; ENSBTAG00000004815. DR eggNOG; ENOG410IGE3; Eukaryota. DR eggNOG; ENOG41114P3; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; E1B821; -. DR OMA; RMFGCEI; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000009136; Chromosome 7. DR Bgee; ENSBTAG00000004815; Expressed in 9 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 298 319 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 201 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 331 AA; 37903 MW; 02634EE48BA071A6 CRC64; MAELANLKLE NKSWPRGTHS LRYHYLDLSE PDPSLPKFQA VGYVDDQPFI RYDSRVDKAE PQAPWIMPMN AKYWEKETKK QRKWAELHQV ETWRMMGYHN HSSVLTGMHS THRMFGCEIQ EDGHSNSFWQ FGYDGQDHVS LDMETLSWVS ANPVALLTKR RMETEHCYAE YNKAYLEGPC LASLRRYLEL GGQRFTRREP PTVWVTKHSA QDGGTTLRCW ALGFYPQDIT LSWWLGEKKL NSKLEYVEAR PSGDGTYQTW MAVWVPAGDE TQYTCHVQHC SLNHTLTVSW EMPSHPGLTA MVISLILILL VFGGGVSLTK CLQVLGGGKG G // ID E1BD63_BOVIN Unreviewed; 360 AA. AC E1BD63; DT 02-NOV-2010, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 12-SEP-2018, entry version 58. DE SubName: Full=Major histocompatibility complex, class I, A-like precursor {ECO:0000313|Ensembl:ENSBTAP00000009299}; GN Name=LOC616942 {ECO:0000313|Ensembl:ENSBTAP00000009299}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000009299, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000009299, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000009299, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000009299} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000009299}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02055391; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E1BD63; -. DR STRING; 9913.ENSBTAP00000009299; -. DR PaxDb; E1BD63; -. DR Ensembl; ENSBTAT00000009299; ENSBTAP00000009299; ENSBTAG00000007075. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; E1BD63; -. DR OMA; HYLEEEC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000009136; Chromosome 23. DR Bgee; ENSBTAG00000007075; Expressed in 9 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 360 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003143897. FT TRANSMEM 304 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 360 AA; 40948 MW; 94B70BC69B66AFE4 CRC64; MRVMGSRTLV LLLPGALVLT ETWAGSHSLR YFYTAVSRPG LEEPRFIIVG YVDDMQFVRF DSDAPDPRME PRARWVEQER PEYWDQATQR TKDTKQTFRA NLNNLRGYYN QSEAGSHTLQ EMYGCDVGSD GGFLRGMQFA YDGRDYIALN EDLRSWTAAD PAAQVSKRKI EQSGAAKGER NYLNRECVEG LRRYLETGKD TLLRTDPPKT HVTCHPISGR EVTLRCWALG FYPEEILLTW QRDGEDQTQD MELVETRPSG DGTFQKWAAL VVPSGEEQRH TCRVQHEGLQ EPRTLRWEPP ETSFLTMGII VGLVLLVVAV VAVVTGAVIW RKKRSGERGH YTQAESKCRG DTIPGTLLRV // ID E1BI37_BOVIN Unreviewed; 350 AA. AC E1BI37; DT 02-NOV-2010, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 12-SEP-2018, entry version 53. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000035745}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000035745, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000035745, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000035745, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000035745} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000035745}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02055382; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E1BI37; -. DR STRING; 9913.ENSBTAP00000035745; -. DR PaxDb; E1BI37; -. DR Ensembl; ENSBTAT00000035878; ENSBTAP00000035745; ENSBTAG00000008959. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; E1BI37; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-BTA-1236974; ER-Phagosome pathway. DR Reactome; R-BTA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-BTA-6798695; Neutrophil degranulation. DR Reactome; R-BTA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000009136; Chromosome 23. DR Bgee; ENSBTAG00000008959; Expressed in 9 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 350 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003144013. FT TRANSMEM 307 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 230 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 350 AA; 40062 MW; 01FB43BDA2E030AE CRC64; MWVTELRTLL LLLSESLALT KTWAGHIHLG HGDPRPKERR PGWQPLPVPG VHSLRYFHIL VSRPGLGRDL YQSVGYLDDT QFVRYNSDTA NPRMEPRAPW MEQEGPQYWD RQTKIAREHS QAESNLQVIV GNHNHSYRES HSFLLSGCDV GPEGCIVRGY EHFAYDGAGY ITLNEDMRSW SAAYTVQIIR RKWEVEGAAE QYGAYVETEC VDWLRKYLEK GKETLRAVPP KTHVTRHPIS DREVTLRCWA LGFYWAEISL TWQRDGEDQT QDMEVVETRA SGDACHVQHE GLQKPLTLRW EPPQTPFLTM GIIVGLVLLV LAVVAGAVIW RKRSDGDGGS YTQTAREDRI // ID E2R0L6_CANLF Unreviewed; 354 AA. AC E2R0L6; DT 30-NOV-2010, integrated into UniProtKB/TrEMBL. DT 31-OCT-2012, sequence version 2. DT 12-SEP-2018, entry version 57. DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSCAFP00000005404}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSCAFP00000005404, GN ECO:0000313|VGNC:VGNC:40803}; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000005404, ECO:0000313|Proteomes:UP000002254}; RN [1] {ECO:0000313|Ensembl:ENSCAFP00000005404, ECO:0000313|Proteomes:UP000002254} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000005404, RC ECO:0000313|Proteomes:UP000002254}; RX PubMed=16341006; DOI=10.1038/nature04338; RG Broad Sequencing Platform; RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., RA Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., RA Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F., RA Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., RA Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., RA Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., RA Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., RA Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., RA Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., RA Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., RA Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., RA Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., RA Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., RA Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., RA Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., RA Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., RA Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., RA Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., RA Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., RA Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., RA Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., RA Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., RA Marabella R., Maru K., Matthews C., McDonough S., Mehta T., RA Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., RA Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., RA Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., RA Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., RA Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., RA Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., RA Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., RA Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., RA Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., RA Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., RA Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., RA Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., RA Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.; RT "Genome sequence, comparative analysis and haplotype structure of the RT domestic dog."; RL Nature 438:803-819(2005). RN [2] {ECO:0000313|Ensembl:ENSCAFP00000005404} RP IDENTIFICATION. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000005404}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAEX03000799; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAEX03000800; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_013974365.1; XM_014118890.1. DR RefSeq; XP_533618.2; XM_533618.6. DR ProteinModelPortal; E2R0L6; -. DR STRING; 9615.ENSCAFP00000005404; -. DR PaxDb; E2R0L6; -. DR Ensembl; ENSCAFT00000005836; ENSCAFP00000005404; ENSCAFG00000003625. DR GeneID; 476414; -. DR CTD; 2217; -. DR VGNC; VGNC:40803; FCGRT. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; E2R0L6; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002254; Chromosome 1. DR Bgee; ENSCAFG00000003625; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; IBA:GO_Central. DR GO; GO:0019864; F:IgG binding; IEA:Ensembl. DR GO; GO:0019770; F:IgG receptor activity; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002254}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002254}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 354 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003163085. FT TRANSMEM 299 320 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 201 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 354 AA; 38758 MW; EF54164C62191684 CRC64; MGVPRPRSWG LGFLLFLLPT LRADSHLSLL YHLTAVSAPP PGTPAFWASG WLGPQQYLSY NNLRAQAEPY GAWVWENQVS WYWEKETTDL RTKEGLFLEA LKALGDGGPY TLQGLLGCEL GPDNTSVPVA KFALNGEDFM TFDPKLGTWN GDWPETETVS KRWMQQAGAV SKERTFLLYS CPQRLLGHLE RGRGNLEWKE PPSMRLKARP GSPGFSVLTC SAFSFYPPEL QLRFLRNGLA AGSGEGDFGP NGDGSFHAWS SLTVKSGDEH HYRCLVQHAG LPQPLTVELE SPAKSSVPVV GIVIGFLLLT AVAVGGALLW RRMRKGLPAP WMSLRGDDVG ALLPTPGVPK DADS // ID E7F9I1_DANRE Unreviewed; 344 AA. AC E7F9I1; DT 08-MAR-2011, integrated into UniProtKB/TrEMBL. DT 08-MAR-2011, sequence version 1. DT 12-SEP-2018, entry version 67. DE SubName: Full=MHC class I antigen transcript variant 1 {ECO:0000313|EMBL:ALL98461.1}; GN Name=mhc1ula {ECO:0000313|EMBL:ALL98461.1, GN ECO:0000313|Ensembl:ENSDARP00000076471}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000076471, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000076471} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000076471}; RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000076471, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000076471, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [3] {ECO:0000313|EMBL:ALL98461.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26254596; DOI=10.1007/s00251-015-0862-1; RA Dirscherl H., Yoder J.A.; RT "A nonclassical MHC class I U lineage locus in zebrafish with a null RT haplotypic variant."; RL Immunogenetics 67:501-513(2015). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; FO904903; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KR086339; ALL98461.1; -; mRNA. DR STRING; 7955.ENSDARP00000076471; -. DR Ensembl; ENSDART00000082034; ENSDARP00000076471; ENSDARG00000059039. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; E7F9I1; -. DR OMA; VPGYYNQ; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF334460; -. DR Reactome; R-DRE-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000000437; Chromosome 22. DR Bgee; ENSDARG00000059039; Expressed in 9 organ(s), highest expression level in pharyngeal gill. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 344 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015289800. FT TRANSMEM 301 320 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 197 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 344 AA; 40291 MW; E4963067D22F7AAB CRC64; MKIIVVFICI PFVCSGYHSL ITTYTGIRGA SETPIFIAVA ILDGEQIDYY DSVTNKLIPK QDWMKEYASE EIWKEDCKIR GDVHQIYRSN INVLMQRFNQ SNGVHVYQRM YGCDWDEETE ESHGFDQYGY DGEDYVMLDM REIRYITPVQ QGEITVQKWN SNREQLKTLQ HYYKYECVYW LKQFLGLRKA DLEIRDPEVF LLQKNPSSPV ECFATGFYPS GVIITWLKNG QDHGENVELR ELKPNEDGTF QRSSSLHVSQ EDWKKSLYTC VVEHQRMTIQ KSGDEIKSNS SSEVFITPER VLAILLAALV ICLCICYLVY PKKLKPYQPV NQNEEMYEYI VKNE // ID E7FAH6_DANRE Unreviewed; 342 AA. AC E7FAH6; DT 08-MAR-2011, integrated into UniProtKB/TrEMBL. DT 08-MAR-2011, sequence version 1. DT 12-SEP-2018, entry version 62. DE SubName: Full=MHC class I antigen transcript variant 1 {ECO:0000313|EMBL:ALL98463.1}; DE SubName: Full=Major histocompatibility complex class I UMA {ECO:0000313|Ensembl:ENSDARP00000057223}; GN Name=mhc1uma {ECO:0000313|EMBL:ALL98463.1, GN ECO:0000313|Ensembl:ENSDARP00000057223, GN ECO:0000313|ZFIN:ZDB-GENE-140820-1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000057223, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000057223} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000057223}; RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000057223, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000057223, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [3] {ECO:0000313|EMBL:ALL98463.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26254596; DOI=10.1007/s00251-015-0862-1; RA Dirscherl H., Yoder J.A.; RT "A nonclassical MHC class I U lineage locus in zebrafish with a null RT haplotypic variant."; RL Immunogenetics 67:501-513(2015). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; FO904903; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KR086346; ALL98463.1; -; mRNA. DR RefSeq; XP_005161940.1; XM_005161883.3. DR UniGene; Dr.130198; -. DR Ensembl; ENSDART00000057224; ENSDARP00000057223; ENSDARG00000039164. DR GeneID; 101883648; -. DR KEGG; dre:101883648; -. DR CTD; 101883648; -. DR ZFIN; ZDB-GENE-140820-1; mhc1uma. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; E7FAH6; -. DR OMA; DWARYDC; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF334519; -. DR Reactome; R-DRE-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000000437; Chromosome 22. DR Bgee; ENSDARG00000039164; Expressed in 6 organ(s), highest expression level in pharyngeal gill. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 342 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015289807. FT TRANSMEM 306 324 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 195 280 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 342 AA; 39944 MW; 7E7A0690B7EF6F97 CRC64; MSIMKFIIFF FNLPFVYSEL HTFVVTYTAM GNQTFFAAAT LDGQQIGHYD KNTKTLVPKQ DWNEQIKSKT PWKVDTLIET VQRTYNNNMH DLIEQFPQSN GAHTYQGRHG CSWEDKTNYH DEFHDYAYDG DDFITLDVKK IKYRASVSKA KYIVKKWNND REQNKTLKEY YKLGCIYWLI EFLVFTKNAF GGTAPKMFLL QKSPNSDVKC HVTGFYSNNI VILWMKNGQE VSNSALLKSG EILPNEDGTF QRTVTLRVSL QYWRKEQYTC VVRYMEKTIR RNLTEEEIKS NYSEMSITAS DSSTSILVPI IVVVLVVSLI LWWMSCHQNC RLGQCFHLEN AN // ID E9PSS8_RAT Unreviewed; 366 AA. AC E9PSS8; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 3. DT 12-SEP-2018, entry version 67. DE SubName: Full=RT1 class Ia, locus A1 {ECO:0000313|Ensembl:ENSRNOP00000039088}; GN Name=RT1-A1 {ECO:0000313|Ensembl:ENSRNOP00000039088, GN ECO:0000313|RGD:1595924}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000039088, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000039088, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000039088, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000039088} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000039088}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044421; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044422; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044423; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044424; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; E9PSS8; -. DR PRIDE; E9PSS8; -. DR Ensembl; ENSRNOT00000041590; ENSRNOP00000039088; ENSRNOG00000038999. DR RGD; 1595924; RT1-A1. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; E9PSS8; -. DR TreeFam; TF336617; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000038999; Expressed in 9 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; E9PSS8; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0030881; F:beta-2-microglobulin binding; IPI:RGD. DR GO; GO:0042277; F:peptide binding; IDA:RGD. DR GO; GO:0046982; F:protein heterodimerization activity; IPI:RGD. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0045953; P:negative regulation of natural killer cell mediated cytotoxicity; IMP:RGD. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:RGD. DR GO; GO:0002657; P:positive regulation of tolerance induction to nonself antigen; IMP:RGD. DR GO; GO:0002517; P:T cell tolerance induction; IMP:RGD. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|PeptideAtlas:E9PSS8}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003242952. FT TRANSMEM 309 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 41238 MW; 337B52554DEE2344 CRC64; MAPRTLLLLL AAALAPTQTR AGSHSMRYFD IAVSRPGLGE PRFIIVGYVD DTEFVRFDSD AEKPRYEPRA PWMEPEGPEY WEEQTRRAKE GEQTFRVNLR TALHYYNQSE DRSHTIQRLS GCDVGSDGRL LRGYEQYAYD GRDYIALNED LKTWTAADFA ARISRNKWDQ AGVAERLRAY LEGECVEWLR RYLELGKETL LRSDPPKAHV TLHPRPEGDV TLRCWALGFY PADITLTWQL NGEDLTQDME LVETRPAGDG TFQKWASVVV PLGKEQNYTC RVEHEGLPEP LSQRWEPPPS TDSNMETTVI YVVLGAVAII AAVIIGAVVT VVRKRRRNTG GKGVYTPAPG TDSSQSSDVS LPDCKA // ID E9PTZ7_RAT Unreviewed; 370 AA. AC E9PTZ7; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 3. DT 12-SEP-2018, entry version 65. DE SubName: Full=RT1 class I, locus1 {ECO:0000313|Ensembl:ENSRNOP00000057743}; GN Name=RT1-CE1 {ECO:0000313|Ensembl:ENSRNOP00000057743}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000057743, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000057743, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000057743, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000057743} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000057743}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044394; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044395; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044396; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044397; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044398; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044399; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044400; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044401; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044402; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044403; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; E9PTZ7; -. DR PRIDE; E9PTZ7; -. DR Ensembl; ENSRNOT00000061027; ENSRNOP00000057743; ENSRNOG00000050183. DR RGD; 1595869; RT1-CE1. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; E9PTZ7; -. DR TreeFam; TF336617; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000050183; Expressed in 9 organ(s), highest expression level in lung. DR ExpressionAtlas; E9PTZ7; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 370 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003245357. FT TRANSMEM 312 338 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 370 AA; 41619 MW; 302472D4AFD35430 CRC64; MGVTAPPLLL LLLAAALART QTRAGSHSLR YFKTAVSRPG LGEPRFMEVG YVDDTEFVRF DSDAENPRYE PRVRWMERQR PEYWERETQG AKEKEQTFRV NLRTLLGYYN QSEGDSHTLQ LMFGCDVGSD GRLLRGYDQF AYDGRDYIAL NEDLKTWAAA DVVAQMTRNK WERARYAEKR RANLEGECVE SLRRYLELGK ETLLRSDPPK AHVTLHPRPE GDVTLRCWAL GFYPADITLT WQLNGEDLTQ DMELVETRPA GDGTFQKWAA VVVPLGKEQN YTCHMEHEGL PEPLTLRWEA PPSTNSNMEF NVIYVVLGAI SAVAIIGAVI IGAVLAVVRK RNTGGKGDYA PAPGRDSSQS SDVSLPDCKA // ID E9PTZ9_RAT Unreviewed; 375 AA. AC E9PTZ9; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 3. DT 12-SEP-2018, entry version 61. DE SubName: Full=RT1 class I, locus1 {ECO:0000313|Ensembl:ENSRNOP00000040885}; GN Name=RT1-CE1 {ECO:0000313|Ensembl:ENSRNOP00000040885}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000040885, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000040885, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000040885, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000040885} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000040885}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044394; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044395; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044396; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044397; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044398; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044399; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044400; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044401; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044402; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044403; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 10116.ENSRNOP00000057743; -. DR PaxDb; E9PTZ9; -. DR PeptideAtlas; E9PTZ9; -. DR Ensembl; ENSRNOT00000049310; ENSRNOP00000040885; ENSRNOG00000050183. DR RGD; 1595869; RT1-CE1. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR OMA; VPGYYNQ; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000050183; Expressed in 9 organ(s), highest expression level in lung. DR ExpressionAtlas; E9PTZ9; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 375 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003242967. FT TRANSMEM 312 338 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 375 AA; 42146 MW; 924853A25E31724B CRC64; MGVTAPPLLL LLLAAALART QTRAGSHSLR YFKTAVSRPG LGEPRFMEVG YVDDTEFVRF DSDAENPRYE PRVRWMERQR PEYWERETQG AKEKEQTFRV NLRTLLGYYN QSEGDSHTLQ LMFGCDVGSD GRLLRGYDQF AYDGRDYIAL NEDLKTWAAA DVVAQMTRNK WERARYAEKR RANLEGECVE SLRRYLELGK ETLLRSDPPK AHVTLHPRPE GDVTLRCWAL GFYPADITLT WQLNGEDLTQ DMELVETRPA GDGTFQKWAA VVVPLGKEQN YTCHMEHEGL PEPLTLRWEA PPSTNSNMEF NVIYVVLGAI SAVAIIGAVI IGAVLAVVRK RNTGRKGQGG KGDYAPAPGR DSSQSSDVSL PDCKA // ID E9PWT4_MOUSE Unreviewed; 310 AA. AC E9PWT4; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 03-OCT-2012, sequence version 2. DT 12-SEP-2018, entry version 59. DE SubName: Full=H-2 class I histocompatibility antigen, Q7 alpha chain {ECO:0000313|Ensembl:ENSMUSP00000077335}; GN Name=H2-Q7 {ECO:0000313|Ensembl:ENSMUSP00000077335, GN ECO:0000313|MGI:MGI:95936}; GN Synonyms=H2-Q4 {ECO:0000313|MGI:MGI:95936}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000077335, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000077335, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000077335, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000077335} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000077335}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR974466; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001185489.1; NM_001198560.1. DR UniGene; Mm.431282; -. DR ProteinModelPortal; E9PWT4; -. DR SMR; E9PWT4; -. DR MaxQB; E9PWT4; -. DR PeptideAtlas; E9PWT4; -. DR PRIDE; E9PWT4; -. DR Ensembl; ENSMUST00000078205; ENSMUSP00000077335; ENSMUSG00000060550. DR GeneID; 15018; -. DR UCSC; uc012arh.1; mouse. DR CTD; 15018; -. DR MGI; MGI:95936; H2-Q7. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000060550; Expressed in 24 organ(s), highest expression level in spleen. DR ExpressionAtlas; E9PWT4; baseline and differential. DR GO; GO:0071346; P:cellular response to interferon-gamma; IEA:Ensembl. DR GO; GO:0007566; P:embryo implantation; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 310 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003243004. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 310 AA; 35182 MW; 8883CE305717824E CRC64; MALTMLLLLV AAALTLIETR AGQHSLQYFH TAVSRPGLGE PWFISVGYVD DTQFVRFDSD AENPRMEPRA RWMEQEGPEY WERETQIAKG HEQSFRGSLR TAQSYYNQSK GGSHTLQWMY GCDMGSDGRL LRGYLQFAYE GRDYIALNED LKTWTAVDMA AQITRRKWEQ AGIAEKDQAY LEGTCMQSLR RYLQLGKETL LRTDPPKAHV THHPRSYGAV TLRCWALGFY PADITLTWQL NGEELTQDME LVETRPAGDG TFQKWASVVV PLGKEQNYTC HVNHEGLPEP LTLRWGRWGG QGGDCAPAPA // ID E9PX63_MOUSE Unreviewed; 341 AA. AC E9PX63; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 12-SEP-2018, entry version 62. DE SubName: Full=Histocompatibility 2, Q region locus 1 {ECO:0000313|Ensembl:ENSMUSP00000100662}; GN Name=H2-Q1 {ECO:0000313|Ensembl:ENSMUSP00000100662, GN ECO:0000313|MGI:MGI:95928}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000100662, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000100662, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000100662, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000100662} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000100662}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR974466; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E9PX63; -. DR SMR; E9PX63; -. DR MaxQB; E9PX63; -. DR PeptideAtlas; E9PX63; -. DR PRIDE; E9PX63; -. DR Ensembl; ENSMUST00000105041; ENSMUSP00000100662; ENSMUSG00000079507. DR UCSC; uc012ard.1; mouse. DR MGI; MGI:95928; H2-Q1. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000079507; Expressed in 19 organ(s), highest expression level in colon. DR ExpressionAtlas; E9PX63; baseline and differential. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; ISO:MGI. DR GO; GO:0042277; F:peptide binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0046977; F:TAP binding; ISO:MGI. DR GO; GO:0019882; P:antigen processing and presentation; IMP:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 341 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003245665. FT TRANSMEM 306 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 341 AA; 38616 MW; B33B89388AC60FED CRC64; MALGRLLLLL AAALTLTKTG AGSHSLRYFE TSVSRPGFGK PRFISVGYVD DTQFVRFDSD AKNPRYEPRA PWMEQEGPEY WERNTRRVKG SEKRFQESLS TLLSYYNQSK GGIHTFQKLS GCDLGSDGRL QSGYLQFAYD GLDYIALNED LETWTAADVA AQETRRKWEQ AGAAEKHRTY LEGKCLMWLH RYLELGKEML LRTDPPKAHV THHPRSQGDV TLRCWALGFY PADITLTWQL NGEELTQDME LVETRPAGDG TFQKWASVVV PLGKEQNYTC HVYHEGLPEP LTLRWEPPPY TVSNMVIIAV LVVLGAVIVI GAVVIIGVMV SFVMKRRRNK A // ID E9Q0G4_MOUSE Unreviewed; 393 AA. AC E9Q0G4; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 12-SEP-2018, entry version 61. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMUSP00000094947}; GN Name=Gm8909 {ECO:0000313|Ensembl:ENSMUSP00000094947, GN ECO:0000313|MGI:MGI:3704134}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000094947, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000094947, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000094947, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000094947} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000094947}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CT030728; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E9Q0G4; -. DR SMR; E9Q0G4; -. DR MaxQB; E9Q0G4; -. DR PRIDE; E9Q0G4; -. DR Ensembl; ENSMUST00000097335; ENSMUSP00000094947; ENSMUSG00000073402. DR MGI; MGI:3704134; Gm8909. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000073402; Expressed in 17 organ(s), highest expression level in colon. DR ExpressionAtlas; E9Q0G4; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:E9Q0G4}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 393 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003245574. FT TRANSMEM 337 360 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 238 326 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 393 AA; 44409 MW; 5DF8A96D138AAFD0 CRC64; MAPRTLLLLL AAALILTETR AATEGPGRRS GSHREPPPGP HSMRYFTTAV SRPGPHSMRY FETAVSRPGL GEPWFISVGY VDDTQFVRFD GDAENPRMEP RAPWMEQEGP EYWERETQIA KGHEQGFQGS LRNLLHYYNQ SAGGSHTFQR MYGCDLGSDG RLLRGYWQFA YDGSDYIALN QDLKTWTAAD LAAQITRRRW EQGGVAETLR AYLEDPCLEW LRRYLELGKE TLLRTDPPKV HVTHHPRSED DVTLRCWALG FYPADITLTW QLNGEELTQD MELVETRPAG DGTFQKWASV VVPLGKEQNY TCHVYHEGLP EPLTLRWEPR PSRDSNMVII AVLVVLGVVI IIGAMVPFVL KSRRKIGGKE ENYALAGGSN SVQGSALFLE AFR // ID E9QC63_DANRE Unreviewed; 381 AA. AC E9QC63; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 3. DT 12-SEP-2018, entry version 57. DE SubName: Full=Major histocompatibility complex class I UKA {ECO:0000313|Ensembl:ENSDARP00000121274}; GN Name=mhc1uka {ECO:0000313|Ensembl:ENSDARP00000121274, GN ECO:0000313|ZFIN:ZDB-GENE-060825-152}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000121274, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000121274} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000121274}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000121274, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000121274, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; FP085393; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSDART00000146579; ENSDARP00000121274; ENSDARG00000092731. DR ZFIN; ZDB-GENE-060825-152; mhc1uka. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; TETWAGH; -. DR Reactome; R-DRE-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000000437; Chromosome 19. DR Bgee; ENSDARG00000092731; Expressed in 17 organ(s), highest expression level in pharyngeal gill. DR ExpressionAtlas; E9QC63; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 381 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015357737. FT TRANSMEM 296 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 212 283 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 381 AA; 43368 MW; 713046442CAD464D CRC64; MEYILLLVVC LPYVDGATHT WNAYYTATTG LSQFPEFVAQ NLIDGQLMGY FDSKTNCFKS QFQWMEDKLG TAYDEQQTNI LQRHTAKFKN NIKVAIERFN QTQGVHTLQE IYGCEWDDQT GNLNAFRQYG YNGEDFLTLD FMEMRWITPV QQAMITTQKW NNDRGFIESD MNYFRSECIE WLQKYLEYGK SSLMKTVSPQ VSVLQKYYFS PVVCHATGFY PSGIKISWQK NGQDHDEDVE LGELLPNADG TFQKRSTLNV KPEEWKNSKF SCVVEHQGER ILTEDEIRTN NPSATIGIII GIVLSAVLLL FIAVAGFVVY WKKKGEKKYS VNSDNDSGCG SGSDSVSHKS SDSTSDISSV CSDNSSDSTT ALLRKCLIFI Y // ID E9QCH2_DANRE Unreviewed; 396 AA. AC E9QCH2; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 2. DT 12-SEP-2018, entry version 58. DE SubName: Full=Major histocompatibility complex class I UKA {ECO:0000313|Ensembl:ENSDARP00000117273}; GN Name=mhc1uka {ECO:0000313|Ensembl:ENSDARP00000117273, GN ECO:0000313|ZFIN:ZDB-GENE-060825-152}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000117273, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000117273} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000117273}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000117273, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000117273, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; FP085393; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E9QCH2; -. DR STRING; 7955.ENSDARP00000117273; -. DR PaxDb; E9QCH2; -. DR Ensembl; ENSDART00000133954; ENSDARP00000117273; ENSDARG00000092731. DR ZFIN; ZDB-GENE-060825-152; mhc1uka. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; E9QCH2; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Reactome; R-DRE-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000000437; Chromosome 19. DR Bgee; ENSDARG00000092731; Expressed in 17 organ(s), highest expression level in pharyngeal gill. DR ExpressionAtlas; E9QCH2; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 396 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003244588. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 222 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 396 AA; 45082 MW; 57D5B962C68EBDF0 CRC64; MADRITQMQK MEYILLLVVC LPYVDGATHT WNAYYTATTG LSQFPEFVAQ NLIDGQLMGY FDSKTNCFKS QFQWMEDKLG TAYDEQQTNI LQRHTAKFKN NIKVAIERFN QTQGVHTLQE IYGCEWDDQT GNLNAFRQYG YNGEDFLTLD FMEMRWITPV QQAMITTQKW NNDRGFIESD MNYFRSECIE WLQKYLEYGK SSLMKTVSPQ VSVLQKYYFS PVVCHATGFY PSGIKISWQK NGQDHDEDVE LGELLPNADG TFQKRSTLNV KPEEWKNSKF SCVVEHQGER ILTEDEIRTN NPSATIGIII GIVLSAVLLL FIAVAGFVVY WKKKGFKPVP ANPVNSDNDS GCGSGSDSVS HKSSDSTSDI SSVCSDNSSD STTALLRNRQ KYDKEN // ID E9QGM2_DANRE Unreviewed; 192 AA. AC E9QGM2; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 12-SEP-2018, entry version 62. DE SubName: Full=MHC class I antigen ZJA transcript variant 2 {ECO:0000313|EMBL:AHA37399.1}; DE SubName: Full=Major histocompatibility complex class I ZJA {ECO:0000313|Ensembl:ENSDARP00000118046}; GN Name=mhc1zja {ECO:0000313|Ensembl:ENSDARP00000118046, GN ECO:0000313|ZFIN:ZDB-GENE-130206-11}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000118046, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000118046} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000118046}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000118046, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000118046, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [3] {ECO:0000313|EMBL:AHA37399.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24287892; DOI=10.1007/s00251-013-0748-z; RA Dirscherl H., Yoder J.A.; RT "Characterization of the Z lineage Major histocompatability complex RT class I genes in zebrafish."; RL Immunogenetics 66:185-198(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CU394254; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC607867; AHA37399.1; -; mRNA. DR UniGene; Dr.113248; -. DR Ensembl; ENSDART00000134062; ENSDARP00000118046; ENSDARG00000074765. DR ZFIN; ZDB-GENE-130206-11; mhc1zja. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000000437; Chromosome 3. DR Bgee; ENSDARG00000074765; Expressed in 15 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 192 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015289914. FT TRANSMEM 135 155 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 27 118 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 192 AA; 22238 MW; E1F9F1182D1BDE52 CRC64; MTSFDRSFTL LYLCLFHVIM SSFRAEKHSL YFIYTGLSRP VDLPGIYEFS AMGLLDDRQI DSYNSEEQRN IPKQQWMKEK MQEDYWENRT QSRKEKQLWF YDNVHLLIDR NRQSTSDGTD LDGIYTGHPP ETVPVVIGSV LIFLAILGVV VFLVMKCGEQ DSSSTDTTEC TSILLGFIAD HLNKELTEGE NW // ID E9QJR9_MOUSE Unreviewed; 325 AA. AC E9QJR9; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 12-SEP-2018, entry version 53. DE SubName: Full=H-2 class I histocompatibility antigen, Q7 alpha chain {ECO:0000313|Ensembl:ENSMUSP00000075606}; GN Name=H2-Q7 {ECO:0000313|Ensembl:ENSMUSP00000075606, GN ECO:0000313|MGI:MGI:95936}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000075606, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000075606, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000075606, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000075606} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000075606}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR974466; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E9QJR9; -. DR SMR; E9QJR9; -. DR MaxQB; E9QJR9; -. DR PRIDE; E9QJR9; -. DR Ensembl; ENSMUST00000076256; ENSMUSP00000075606; ENSMUSG00000060550. DR MGI; MGI:95936; H2-Q7. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000060550; Expressed in 24 organ(s), highest expression level in spleen. DR ExpressionAtlas; E9QJR9; baseline and differential. DR GO; GO:0071346; P:cellular response to interferon-gamma; IEA:Ensembl. DR GO; GO:0007566; P:embryo implantation; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 325 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003246241. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 325 AA; 37250 MW; DFB9E29C3E66580E CRC64; MALTMLLLLV AAALTLIETR AGQHSLQYFH TAVSRPGLGE PWFISVGYVD DTQFVRFDSD AENPRMEPRA RWMEQEGPEY WERETQIAKG HEQSFRGSLR TAQSYYNQSK GGSHTLQWMY GCDMGSDGRL LRGYLQFAYE GRDYIALNED LKTWTAVDMA AQITRRKWEQ AGIAEKDQAY LEGTCMQSLR RYLQLGKETL LRTDPPKAHV THHPRSYGAV TLRCWALGFY PADITLTWQL NGEELTQDME LVETRPAGDG TFQKWASVVV PLGKEQNYTC HVNHEGLPEP LTLRWEPPPY TVSNMATIAV VVLELWPSLE LWWLL // ID F1LQF2_RAT Unreviewed; 365 AA. AC F1LQF2; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 2. DT 12-SEP-2018, entry version 62. DE SubName: Full=RT1 class Ib, locus S3 {ECO:0000313|Ensembl:ENSRNOP00000001036}; GN Name=RT1-S3 {ECO:0000313|Ensembl:ENSRNOP00000001036, GN ECO:0000313|RGD:735037}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000001036, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000001036, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000001036, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000001036} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000001036}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044362; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001008886.2; NM_001008886.2. DR RefSeq; XP_006255979.1; XM_006255917.3. DR UniGene; Rn.196348; -. DR ProteinModelPortal; F1LQF2; -. DR STRING; 10116.ENSRNOP00000001036; -. DR PaxDb; F1LQF2; -. DR Ensembl; ENSRNOT00000001036; ENSRNOP00000001036; ENSRNOG00000000777. DR GeneID; 294228; -. DR KEGG; rno:294228; -. DR CTD; 294228; -. DR RGD; 735037; RT1-S3. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F1LQF2; -. DR KO; K06751; -. DR OMA; GYCQEAY; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000000777; Expressed in 10 organ(s), highest expression level in spleen. DR ExpressionAtlas; F1LQF2; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003269088. FT TRANSMEM 308 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 41367 MW; 110DF38D0AE7A494 CRC64; MRMLPPAYLL QLLAGTMVLT QTSSHSLRYF YTALSRPGLG EPRFIVVGYV DDTQFVRYDS DVENPRMEPR ARWMEQEEPA YWERETRKAR DTGRNFKVNL RTLLRYYNQS DDESHTLQWM YGCDVGPDGH LLRGYCQEAY DGRDYISLNE DLRSWTATDM ASQASKIKSE EVGEAHHQRA YLQGPCVEWL HTYLHLGKET LLRSDPPKAH VTLHPRPEGD VTLRCWALGF YPADITLTWQ LNGEDLTQDM ELVETRPAGD GTFQKWAAVV VPSGEELKYT CHVEHEGLPE PLALRWEPSP FTDSSMPVIV VLGAVAIIGA VAIIGAVAII GAVVRRRKRN TGEKGSYAHV LGSKAFQISD WPQKA // ID F1LSU0_RAT Unreviewed; 341 AA. AC F1LSU0; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 2. DT 12-SEP-2018, entry version 62. DE SubName: Full=RT1 class Ib, locus M4 {ECO:0000313|Ensembl:ENSRNOP00000030382}; GN Name=RT1-M4 {ECO:0000313|Ensembl:ENSRNOP00000030382, GN ECO:0000313|RGD:1562593}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000030382, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000030382, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000030382, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000030382} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000030382}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC108572; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001161815.1; NM_001168343.1. DR RefSeq; XP_006255933.1; XM_006255871.3. DR UniGene; Rn.222433; -. DR ProteinModelPortal; F1LSU0; -. DR STRING; 10116.ENSRNOP00000030382; -. DR PaxDb; F1LSU0; -. DR Ensembl; ENSRNOT00000030174; ENSRNOP00000030382; ENSRNOG00000060412. DR GeneID; 309584; -. DR KEGG; rno:309584; -. DR CTD; 309584; -. DR RGD; 1562593; RT1-M4. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F1LSU0; -. DR KO; K06751; -. DR OMA; NTRICKA; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000060412; Expressed in 3 organ(s), highest expression level in testis. DR ExpressionAtlas; F1LSU0; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 341 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003269129. FT TRANSMEM 308 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 341 AA; 38749 MW; C74ED0D48668FC60 CRC64; MGSVVPRIFF LLLVTSLAPT QAGAGSHSLR YFTTTLYDPG YRKPRFTVVG YVDNTQIVNF DSHLASQRVE PRVPFIAQDP EHLEELTRLG RGILILGRIE LWTLFGYHSQ RENESHTVQW LFGCDIGPDR RLLRGYKHVA YEGQDYISLT EDLRSWVAVD TEEAQITRRK WEASGIATSW RSFLEGRCVK WLLKYLDKGK EMLQRADPPK TNVAHHPRPE GDVTLRCWAL DFYPADIILT WQRDEEDLTQ DMDLVETRPT GNGTFQKWAS VVVPSGEEHR YTCHVLHEGL LEPLILRWEP SPSPTTPIMG IIAGLVLLGV LVTGTVAAIM RRRKSAGKDG V // ID F1LXB3_RAT Unreviewed; 281 AA. AC F1LXB3; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 2. DT 12-SEP-2018, entry version 58. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSRNOP00000058011}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000058011, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000058011, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000058011, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000058011} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000058011}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044364; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 10116.ENSRNOP00000058011; -. DR PaxDb; F1LXB3; -. DR Ensembl; ENSRNOT00000061299; ENSRNOP00000058011; ENSRNOG00000000787. DR eggNOG; ENOG410J90V; Eukaryota. DR eggNOG; ENOG41117CA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F1LXB3; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000000787; Expressed in 9 organ(s), highest expression level in lung. DR ExpressionAtlas; F1LXB3; baseline and differential. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}. FT DOMAIN 192 280 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 281 AA; 32754 MW; B807C6C805087FB9 CRC64; SHSLHYSYSA VTEPGPGVPA FFASGFVDNQ PFIHYDSRKM EAEPCADWLR ENPYYLADET QVFTNWMKTL QLSLRNIQQY YNSSGDRSQR ADGFHQQAGP HTLQFTYGCE MQDNRTTGHW HYGYDGRDYL TLDLDSMQYT AATFIAGYTK HKWQNNEYWL EREKTYLEKE CVLWLKRYLT MGGENFTRTD PPRTTVTHHP RPEGDVTLRC WALGFYPADI TLTWQLNGED LTQEMELVET RPAGDGTFQK WASVVVPSGE EQKYTCRVEH EGLPEPLTLR W // ID F1M115_RAT Unreviewed; 353 AA. AC F1M115; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 3. DT 12-SEP-2018, entry version 57. DE SubName: Full=RT1 class I, locus CE11-like {ECO:0000313|Ensembl:ENSRNOP00000051211}; GN Name=LOC100364500 {ECO:0000313|Ensembl:ENSRNOP00000051211, GN ECO:0000313|RGD:2320860}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000051211, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000051211, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000051211, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000051211} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000051211}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044333; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 10116.ENSRNOP00000051211; -. DR PaxDb; F1M115; -. DR PeptideAtlas; F1M115; -. DR PRIDE; F1M115; -. DR Ensembl; ENSRNOT00000048535; ENSRNOP00000051211; ENSRNOG00000048951. DR RGD; 2320860; LOC100364500. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F1M115; -. DR OMA; MKNATQT; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000048951; Expressed in 9 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; F1M115; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 293 317 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 190 278 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 353 AA; 39458 MW; 0F882A9C5D418166 CRC64; APPPGSHSMR CFKTAVSRPG LGEPRFIAVA YVDDTEFVRY DGDAENPRTE PRARWMEREG PEYWEEETRK IKGQEQWFRM SLRILRGYYN QSEGGSHTFQ KMSGCDVGSD GSLLRGYNQY AYDGHDYIAL NKDLKTWTAA DFAALITKTK WDQAGTAERK RAYLEGTCXV EWLRRYLELG KETLLRSDPP KAHVTLHPRP EGDVTLRCWA LGFYPADITL TWQLNGEDLT QDMELVETRP AGDGTFQKWA AVVVPLGKEQ NYTCLVEHEG LPEPLTLRWE APPGTDSNME TKVIYVVLGA VAMIGAVAVI GAVVAVVRRR RRKRNTGGTG GDYAPAPGSD SCQSSDVSLA DCE // ID F1M9F3_RAT Unreviewed; 330 AA. AC F1M9F3; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 3. DT 12-SEP-2018, entry version 64. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSRNOP00000045388}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000045388, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000045388, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000045388, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000213|PubMed:16641100} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=16641100; DOI=10.1073/pnas.0600895103; RA Hoffert J.D., Pisitkun T., Wang G., Shen R.F., Knepper M.A.; RT "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: RT regulation of aquaporin-2 phosphorylation at two sites."; RL Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006). RN [3] {ECO:0000313|Ensembl:ENSRNOP00000045388} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000045388}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044383; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044384; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; F1M9F3; -. DR PRIDE; F1M9F3; -. DR Ensembl; ENSRNOT00000048076; ENSRNOP00000045388; ENSRNOG00000059770. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F1M9F3; -. DR OMA; EDRTHNT; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000059770; Expressed in 9 organ(s), highest expression level in liver. DR ExpressionAtlas; F1M9F3; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 330 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003269182. FT TRANSMEM 301 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 219 276 IGc1. {ECO:0000259|SMART:SM00407}. SQ SEQUENCE 330 AA; 37415 MW; 4EA0EA9A83401086 CRC64; MAPRTLLLLL AAALAPTQTQ AGSHSLRYFD IAVSRPGLGE PRFIIVGYVD DREVMRFDSD AENPRMKPRA RWMEREGPEY WERQTRKVKE KEQIFRDNLR TLLRYYNQSE GGSHTVQRLS GCDVGSDGSL LRGYNQHAYD GRDYIALNED LKTWTAADTA AQITKNKWER DGEAERRRAY LEGECVEWLR SYLAPRKETL LRSDPPKAHV TLHPRPEGDV TLRCWALGFY PAGISLTWQL NGEDLTQDME LVETRPAGDG TFQKWGCLFW SGLRAGVMTP PSFPVPVLPR APSTDSNMET YVIYVILGAV AIIAAVIIVA VVAVVMKRRR // ID F1MAQ9_RAT Unreviewed; 355 AA. AC F1MAQ9; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 3. DT 12-SEP-2018, entry version 63. DE SubName: Full=RT1 class I, locus CE7 {ECO:0000313|Ensembl:ENSRNOP00000057830}; GN Name=RT1-CE7 {ECO:0000313|Ensembl:ENSRNOP00000057830, GN ECO:0000313|RGD:1595786}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000057830, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000057830, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000057830, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000057830} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000057830}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044398; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044399; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044400; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044401; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044402; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044403; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044404; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044405; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044406; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044407; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PRIDE; F1MAQ9; -. DR Ensembl; ENSRNOT00000061114; ENSRNOP00000057830; ENSRNOG00000031090. DR RGD; 1595786; RT1-CE7. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000031090; Expressed in 9 organ(s), highest expression level in spleen. DR ExpressionAtlas; F1MAQ9; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 355 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003267245. FT TRANSMEM 310 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 355 AA; 39841 MW; A2FA2295AA7E89C0 CRC64; MAPRTLLLLL AAALAPTRTR AGSHSLRYFH TAVSRPGLGE PRFIIEVGYV DDTEFVRFDS DAENPRMEPR ARWMEREGPE YWDRETRIAK GNEQRFRVHL RTLLGHYNQS EGGSHTIQRM YGCDVGSDGS LLRGYEQSAY DGRDYIALNE DLKTWTAADV AAQITRNKWD QAGVAERRRA YLEGTCMKWL RRYLEHGKET LLRSDPPKAH VTLHPRPEGD VTLRCWALGF YPADITLTWQ LNGEDLTQDM ELVETRPAGD GTFQKWASVV VPPGKEQNYT CRVEHEGLPE PLTLRWEAPP STDSNMETNV IYVVIGAISA VAIIGAVLAV VRKKNTGGTG GDYTPAPARQ LSGVD // ID F1MAR7_RAT Unreviewed; 357 AA. AC F1MAR7; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 2. DT 12-SEP-2018, entry version 61. DE SubName: Full=RT1 class Ib, locus M5 {ECO:0000313|Ensembl:ENSRNOP00000045665}; GN Name=RT1-M5 {ECO:0000313|Ensembl:ENSRNOP00000045665, GN ECO:0000313|RGD:1595816}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000045665, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000045665, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000045665, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000045665} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000045665}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC108572; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001161825.1; NM_001168353.1. DR UniGene; Rn.201527; -. DR ProteinModelPortal; F1MAR7; -. DR STRING; 10116.ENSRNOP00000045665; -. DR PaxDb; F1MAR7; -. DR Ensembl; ENSRNOT00000052311; ENSRNOP00000045665; ENSRNOG00000033136. DR GeneID; 499400; -. DR CTD; 499400; -. DR RGD; 1595816; RT1-M5. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F1MAR7; -. DR OMA; RMFGCEI; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000033136; Expressed in 3 organ(s), highest expression level in testis. DR ExpressionAtlas; F1MAR7; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 357 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003269213. FT TRANSMEM 308 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 357 AA; 39998 MW; 203ADBD9FE606902 CRC64; MGSSVFSVLL PLLLSRAWAL NQVGAGIHSL QFFATAVTQP SSREHSFIFV GFVDDTQFLC YNNQGESQRM EPRALWVKNM GPGYWERQTR MVKDISKNSL VNLREAMSVY NHSEDGTHVF QCVSGCDVGP DGLFLRGHEQ HAYDGRDYLA LNKDLHSWTA GDTAAQITRR KWEEAGVAEQ RRTYLKGECV ESLRTYLEIG KETLLGADPP KAHVTHHPSP EGDNTLRCWA LGFYPSDITL TWQRDGEDLT QDMELVETRP GGDGTFQKWA AVVVPSGEEH RYTCCVEHEG LTEPLLLKWD PSKHTIPIMG ITAGLVFLGV AFTGAVVAIA MRKQRGCRVL TPSKAHLERS DKYLTWT // ID F1MGC3_BOVIN Unreviewed; 353 AA. AC F1MGC3; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 12-SEP-2018, entry version 56. DE SubName: Full=Major histocompatibility complex, class I precursor {ECO:0000313|Ensembl:ENSBTAP00000048068}; GN Name=LOC512672 {ECO:0000313|Ensembl:ENSBTAP00000048068}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000048068, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000048068, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000048068, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000048068} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000048068}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02055404; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1MGC3; -. DR STRING; 9913.ENSBTAP00000048068; -. DR PaxDb; F1MGC3; -. DR Ensembl; ENSBTAT00000052679; ENSBTAP00000048068; ENSBTAG00000038619. DR eggNOG; ENOG410J90V; Eukaryota. DR eggNOG; ENOG41117CA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F1MGC3; -. DR OMA; TSRMKIF; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000009136; Chromosome 23. DR Bgee; ENSBTAG00000038619; Expressed in 9 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 353 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003265959. FT TRANSMEM 310 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 300 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 353 AA; 41387 MW; 4B2C2CCDD9502E3B CRC64; MLWGPVLLYF FLAYLPETQT RSHSLQYFYS VVSEPGPGVP SFMAFGFVDN QPFIRYDSEE MKAKSCVHWL REEPSYFDDE TKIFTSRMKI FHLNLRNVQQ YYNQTKEDGL NRALAQKQTS PHTLQFTYGC ELLEDGRTTW HWQYGYDGED YLSLHMDPLQ YTAATFVAQY TKQKWEAGGN FIERDKNYLE KECILWLWRY LTFGGESLNR TEPPKTHMTH HRISDREVTL RCWALGFYPA KISLTWQRNG EDQTQDMELV ETRPSGDGTF QKWAALVVPS GEEQKYTCRV QHEGLQEPLT LRWEPLKTSV PITGIIVVLV LLVVTRAVIW IKKLSGYYHS TNGKNRTYFQ TAI // ID F1MJW2_BOVIN Unreviewed; 298 AA. AC F1MJW2; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 12-SEP-2018, entry version 42. DE SubName: Full=Major histocompatibility class I related protein precursor {ECO:0000313|Ensembl:ENSBTAP00000013413}; GN Name=MIC1 {ECO:0000313|Ensembl:ENSBTAP00000013413}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000013413, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000013413, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000013413, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000013413} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000013413}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02055385; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02055386; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9913.ENSBTAP00000013413; -. DR PaxDb; F1MJW2; -. DR Ensembl; ENSBTAT00000013413; ENSBTAP00000013413; ENSBTAG00000010166. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F1MJW2; -. DR OMA; DINEDSH; -. DR OrthoDB; EOG091G0ANY; -. DR TreeFam; TF342166; -. DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000009136; Chromosome 23. DR Bgee; ENSBTAG00000010166; Expressed in 10 organ(s), highest expression level in lung. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 298 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003269456. FT TRANSMEM 229 249 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 24 189 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 298 AA; 33903 MW; A9D2EAFC288DDD2B CRC64; MGLSHVWLFL AHAAFFVLLG NAAGSHSLLY NMTVLSRDGF VQSRFFAEGY LDRQAFLHYD HKKGRAEPWG RWPEKLAAET WETETMDLNE SWKELRKLLA EILSLQEEKG GLHSLQETVG CDINEDSHPQ GFRLLYFNGE LLLSCYPEPH GCTLPQSSAR TLAMEMELSK HYQAHVQGEL CRRLRSYLES WPGFTERTEP PAVNVTCSQD SEGMVHLTGK TLVHQRSRWI VSIPVAVVFI IGFCVYCYIK KRKTASATGR PEPIRLQDLD QFQTEPTDHN GLTHPEFQSL CHTPAPSV // ID F1MPL6_BOVIN Unreviewed; 359 AA. AC F1MPL6; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 12-SEP-2018, entry version 52. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000025832}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000025832, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000025832, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000025832, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000025832} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000025832}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02055404; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9913.ENSBTAP00000025832; -. DR PaxDb; F1MPL6; -. DR Ensembl; ENSBTAT00000025832; ENSBTAP00000025832; ENSBTAG00000005146. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F1MPL6; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000009136; Chromosome 23. DR Bgee; ENSBTAG00000005146; Expressed in 9 organ(s), highest expression level in colon. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 303 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 40408 MW; 13A58FE4F04487EF CRC64; MRVMGPRTLL QLLSGILVLI ETLAAFHSLR YFYTAVSRPG LGEPRFIIVG YVDDTEFVRF DSDAPDPRME PRARWVEQEG PEYWDQETRK AKDAAQTFRA NLNSLRGYYN QSEAGSHTLQ LMYGCDVGPD GSLLRGYEQY GYDGRDYIAL NEDLRSWTAA DTAAQISKRK VEAAGDAARV RIYLGRCVES LRRYLETGKE TLLRADPPKA HVTHHPISGR EVTLRCWALG FYPEEILLTW QHNGEDQTQD MELVETRPGD GNFQKWAALV VPSGEEQRYT CHVQHEGLQE PLTLRWEPPQ TPFLTMGIIV GLVLLVVAVV AGAVIWRKKR SGEKGRTYTQ ASSSDSAQGS DVSLTVPKV // ID F1MQX6_BOVIN Unreviewed; 180 AA. AC F1MQX6; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 12-SEP-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000048618}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000048618, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000048618, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000048618, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000048618} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000048618}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02027078; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9913.ENSBTAP00000048618; -. DR PaxDb; F1MQX6; -. DR Ensembl; ENSBTAT00000053728; ENSBTAP00000048618; ENSBTAG00000038891. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F1MQX6; -. DR OMA; FLVHWEE; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Reactome; R-BTA-163125; Post-translational modification: synthesis of GPI-anchored proteins. DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000009136; Chromosome 9. DR Bgee; ENSBTAG00000038891; Expressed in 7 organ(s), highest expression level in heart. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}. FT DOMAIN 3 174 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 180 AA; 20744 MW; 8C90412A2400A964 CRC64; TDAHSLCYNF TVDSQPRPGQ PWCVVQGQVD GKVFLSYDCG RAKIQFTSPL GEEVKTTKAW ETQTETLRDI GDLLREQLPD VTSEKRTVTD PLTLQGRMTC RCEDDGHISG SWQFGFSGQM CLLFDSENGH WTEVHSGGRR MREKWEKDRA VTNFFKKVSM GDCRVWLQDF LVHWEEMLKT // ID F1MRK8_BOVIN Unreviewed; 315 AA. AC F1MRK8; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 12-SEP-2018, entry version 39. DE SubName: Full=Retinoic acid early transcript 1G precursor {ECO:0000313|Ensembl:ENSBTAP00000052134}; GN Name=RAET1G {ECO:0000313|Ensembl:ENSBTAP00000052134}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000052134, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000052134, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000052134, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000052134} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000052134}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02027073; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02027074; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02027075; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02027076; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02027077; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02027078; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02027079; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02027080; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02027081; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02027082; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1MRK8; -. DR STRING; 9913.ENSBTAP00000052134; -. DR PaxDb; F1MRK8; -. DR Ensembl; ENSBTAT00000057496; ENSBTAP00000052134; ENSBTAG00000039329. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F1MRK8; -. DR OMA; VAWILYK; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Reactome; R-BTA-163125; Post-translational modification: synthesis of GPI-anchored proteins. DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000009136; Chromosome 9. DR Bgee; ENSBTAG00000039329; Expressed in 8 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 33 {ECO:0000256|SAM:SignalP}. FT CHAIN 34 315 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003269588. FT TRANSMEM 231 251 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 31 206 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 315 AA; 35768 MW; 032C67195188A105 CRC64; MAKGERGGPE TRLGFLDLLL IVWFSGTPGD AHSLSFDFTV DPQPRPGHPW CEIQSQVDGK VFLSYDCGHA KIIIPSVLRE EVKTINAWET QIETLRDIRD WIKDHMHDFT MEKHMPRDPR TLQARMTCRC EDDRHVSGSW QFGLNGVMIL HFDSENGHWR VDHPGGRWMK EKWENDRAVT DFLKKVSMGD CRGWLQDFMV RWKEILKTTA SPTTVPPTVQ PTAPPISHVT WIAPGVLVSF VIMGIVAWIL YKKRRLCSQE APDRCSVGLR TQCLLGCFCS PAFTLEPRDQ TLGVSSLSTS YDDTVAAPSR VSCQI // ID F1MWX3_BOVIN Unreviewed; 362 AA. AC F1MWX3; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 12-SEP-2018, entry version 52. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000035741}; GN Name=BOLA {ECO:0000313|Ensembl:ENSBTAP00000035741}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000035741, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000035741, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000035741, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000035741} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000035741}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02055392; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1MWX3; -. DR STRING; 9913.ENSBTAP00000035741; -. DR PaxDb; F1MWX3; -. DR Ensembl; ENSBTAT00000035874; ENSBTAP00000035741; ENSBTAG00000022590. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR OMA; QPRFIAV; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000009136; Chromosome 23. DR Bgee; ENSBTAG00000022590; Expressed in 9 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003266610. FT TRANSMEM 304 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 41063 MW; 32E91EB263D080E8 CRC64; RVMGPRTLLL LLSGVLVLTE TWAGSHSLSY FNTGVYQPGL GEPRFFAVGY VDDTQFARFD SDAPNPRMEP RAPWMEQEGP EYWEEMTRDA KESQQKSRLC LYNLRGYYNQ SEAESHILQV MFGCEVGPDG RLLRGFWQKA YDGRDYIALN EDLRSWTAAD TVAQITKRKW DVSGQAKIQR NYLEVKCVQW LLRHLETGKD TLLRADPPKT HVAHHRISDR EVTLRCWALG FYPKEITLTW QQDGEDLTQD MELVETRPSG DGTFQKWAAL VVPSGEEQRY TCRVQHEGLQ EPLTLRWEPP QLSVLIKGII VGLILLMVTG AVVTGAVIWR KKHSGEKGRG YTQTASSDSA QGSDVSLTVP KG // ID F1MWX8_BOVIN Unreviewed; 362 AA. AC F1MWX8; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 12-SEP-2018, entry version 57. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000011795}; GN Name=JSP.1 {ECO:0000313|Ensembl:ENSBTAP00000011795}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000011795, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000011795, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000011795, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000011795} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000011795}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02055405; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9913.ENSBTAP00000011795; -. DR PaxDb; F1MWX8; -. DR Ensembl; ENSBTAT00000011795; ENSBTAP00000011795; ENSBTAG00000020116. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F1MWX8; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000009136; Chromosome 23. DR Bgee; ENSBTAG00000020116; Expressed in 9 organ(s), highest expression level in lung. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003269987. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 41025 MW; 4C263ACA4D75BEAC CRC64; MRVMGPRTLL LLLSGVLVLT ETRAGSHSLR YFYTAVSRPG LGEPRFIIVG YVDDTQFVRF DSDAGDPRVE PRARWVEQEG PEYWDQETRK AKDHAQFFRL GLNTLRGYYN QSEAGSHTLQ WMYGCDVGPD GRLLRGFWQF GYEGRDYIAL NEDLRSWTAA DTAAQISKRK WEAADVAERQ RNYLEGTCVE WLPRYLENGK DTLLRADPPK AHVTHHPISG REVTLRCWAL GFYPEEISLT WQRNGEDQTQ DMELVETRPS GDGTFQKWVA LVVPSGEEQR YTCSVQHEGL QEPLTLRWEP PQTSFLTMGI IVGLVLLVTG AVVAGFVIWM KKRSGEKGGN YIQASRSDSA QGSDVSLTVP KV // ID F1MZE6_BOVIN Unreviewed; 230 AA. AC F1MZE6; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 12-SEP-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000011321}; GN Name=LOC107131217 {ECO:0000313|Ensembl:ENSBTAP00000011321}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000011321, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000011321, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000011321, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000011321} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000011321}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02048561; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1MZE6; -. DR STRING; 9913.ENSBTAP00000011321; -. DR PaxDb; F1MZE6; -. DR Ensembl; ENSBTAT00000011321; ENSBTAP00000011321; ENSBTAG00000023970. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F1MZE6; -. DR OMA; NISMGDC; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Reactome; R-BTA-163125; Post-translational modification: synthesis of GPI-anchored proteins. DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000009136; Chromosome 19. DR Bgee; ENSBTAG00000023970; Expressed in 8 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}. FT DOMAIN 23 192 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 230 AA; 25962 MW; F1F71DE7395A9F1E CRC64; LGEGASGSFS PTSPSLCFAF TDAHSLSYNV TIDPRPRDGQ PWCEVQGEVD QKVFLSYDCG RAKIKSISPL GEEVKSMNAW ETQINTLKDT GDLLKEQMPD VTPEKHIDKG PLTLQARMTC WREDNGHTSA SWEFGFNGQL CLLFDSENGY WTMVHSKGRW MKEKWENDRA VTEFFKKVSM GDCQRWYHTF LLSWEKMLKT AGKASPTEAP LRVNSTATAT KHVTCILPVL // ID F1MZQ5_BOVIN Unreviewed; 364 AA. AC F1MZQ5; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 12-SEP-2018, entry version 57. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000016194}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000016194, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000016194, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000016194, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000016194} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000016194}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02055385; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1MZQ5; -. DR STRING; 9913.ENSBTAP00000016194; -. DR PaxDb; F1MZQ5; -. DR Ensembl; ENSBTAT00000016194; ENSBTAP00000016194; ENSBTAG00000012208. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F1MZQ5; -. DR OMA; TESWIAP; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000009136; Chromosome 23. DR Bgee; ENSBTAG00000012208; Expressed in 9 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003269868. FT TRANSMEM 311 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 213 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 41049 MW; CCD2B9D5CB1294C9 CRC64; QTRRIRVMGP RTLLLLLSEV LVLTETWAGS HSLSYFCTCV SRPGLGEPRF FAVGYVDDTQ FARFDSDAPN PRMEPRAPWM EQEGPEYWEA MTRDAKKAQQ RLRTGLNTLR GFYNQSEAGS HTLQWVFGCD VGPEGRLLRG IWQNAYDGAD YLALNEDLRS WTAANTVAQI TKRKWETSGE AEFQRNYLEV KCVQWLLRHL ETGKDTLLRA DPPKTHVAHH PISDREVTLR CWALGFYPEE ISLTWQQDGE DQTQDMELVE TRPSGDGTFQ KWAALVVPSG EEQRYTCHVQ HEGLQEPLSL RWKPPQPSIP IMGIIVGLVL LMVTGAVVTG AVIWRKGQTG RGYTQAASSD SAQGSDVSLM VPKV // ID F1N2K5_BOVIN Unreviewed; 240 AA. AC F1N2K5; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 12-SEP-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000045991}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000045991, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000045991, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000045991, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000045991} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000045991}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02027095; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9913.ENSBTAP00000045991; -. DR PaxDb; F1N2K5; -. DR Ensembl; ENSBTAT00000049047; ENSBTAP00000045991; ENSBTAG00000039875. DR eggNOG; ENOG410JBPA; Eukaryota. DR eggNOG; ENOG411150N; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F1N2K5; -. DR OMA; WENEKEL; -. DR OrthoDB; EOG091G0NI5; -. DR TreeFam; TF339658; -. DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000009136; Chromosome 9. DR Bgee; ENSBTAG00000039875; Expressed in 5 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 240 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003267759. FT DOMAIN 51 201 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 240 AA; 26808 MW; 94AFC94453565DD8 CRC64; QGRMPLAQTT GHLLLILLLI EARKTPGNAH SLCQDLTVKS QSRPGHLHMC QVQGSVDTKP FLWYDSDSNK VKPLGFLGKE VNDTKAWTEI SQTLVAAGRE LRMVLPVIKL DKRGTGPPTL QVKLCCQREA EQCSGASHFS LNGQTALLLD TMSITWTVID PGATGIKEEW ENNQELAEYF RTISTGDCSY WLWEFLKHWE KMLLPEPTEP IIMAPDISQS ASIRLVSCII LLIITQLVLI // ID F1N3I2_BOVIN Unreviewed; 352 AA. AC F1N3I2; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 12-SEP-2018, entry version 58. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000026794}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000026794, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000026794, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000026794, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000026794} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000026794}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02055386; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1N3I2; -. DR STRING; 9913.ENSBTAP00000026794; -. DR PaxDb; F1N3I2; -. DR Ensembl; ENSBTAT00000026794; ENSBTAP00000026794; ENSBTAG00000001476. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F1N3I2; -. DR OMA; KTHITHY; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000009136; Chromosome 23. DR Bgee; ENSBTAG00000001476; Expressed in 9 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 352 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003270190. FT TRANSMEM 297 319 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 82 102 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 352 AA; 39955 MW; 91C2A73FAB99F131 CRC64; LLLLSGVLVL TETWPGSHSL SYFCTCVSRP GLGEPRFFAV GYVDRTQFAR FDSDAPNPRM EPRAPWMEQE GPEYWEEMTR DAKKAQQRMR LALNNLRGYY NQSEAGSHTL QFVFGCHVGL DGRLLRGIWR TAYDGADYLL NEDLRSWTAA NTVAQITKRK WETSGEAEFQ RNYLEVKCVQ WLLRHLEKGK DTLLRADPPK TNVAHHRISD HDITLRCWAL GFYPEEISLT WQRDREDQTQ DMEFVETRPS GDGTFQKWVA LVVPSGEEQR YTCCVQHEGL QKPLTLRWEP PQPSIPIMGI IVGVLLMVTG AVVTEAVIWR KKHSGEVGRG YTQAASNDGA QGSGVPLTVL KG // ID F1N4S4_BOVIN Unreviewed; 252 AA. AC F1N4S4; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 12-SEP-2018, entry version 41. DE SubName: Full=UL16-binding protein 11 precursor {ECO:0000313|Ensembl:ENSBTAP00000002400}; GN Name=ULBP11 {ECO:0000313|Ensembl:ENSBTAP00000002400}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000002400, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000002400, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000002400, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000002400} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000002400}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02048565; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9913.ENSBTAP00000002400; -. DR PaxDb; F1N4S4; -. DR Ensembl; ENSBTAT00000002400; ENSBTAP00000002400; ENSBTAG00000001836. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F1N4S4; -. DR OMA; YEITIIP; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Reactome; R-BTA-163125; Post-translational modification: synthesis of GPI-anchored proteins. DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000009136; Chromosome 19. DR Bgee; ENSBTAG00000001836; Expressed in 7 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 252 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003270043. FT TRANSMEM 226 247 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 26 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 252 AA; 28386 MW; A783E6DC24F2E5A4 CRC64; MGGSESSLGF LVLLLIVLFS GTSSDAHSLS YNVTIDPRPR DGQPWCEVQG EVDQKVFLSY DCGRAKIKYM SPLGEEVKSM NAWETQTDTL KDIGDLLKEQ MPGVTPEKHI DKVGSGPLTL QARMTCWRED NGHTSASWEF GFNGQLCLLF DSENGHWTMV HSKGRRMKEK WENDRDVTDF FKKVSMGDCQ HWYQDFLLSW KKMLKTTASL TTGPSTMQPM APDSSYIAWI ATGVLAGFVI IIVLACIHYK NR // ID F1N4Y5_BOVIN Unreviewed; 342 AA. AC F1N4Y5; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 12-SEP-2018, entry version 55. DE SubName: Full=Non-classical MHC class I antigen precursor {ECO:0000313|Ensembl:ENSBTAP00000021451}; GN Name=BOLA-NC1 {ECO:0000313|Ensembl:ENSBTAP00000021451}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000021451, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000021451, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000021451, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000021451} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000021451}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02055405; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1N4Y5; -. DR STRING; 9913.ENSBTAP00000021451; -. DR PaxDb; F1N4Y5; -. DR Ensembl; ENSBTAT00000021451; ENSBTAP00000021451; ENSBTAG00000019386. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F1N4Y5; -. DR OMA; FQRMIGC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000009136; Chromosome 23. DR Bgee; ENSBTAG00000019386; Expressed in 9 organ(s), highest expression level in lung. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F1N4Y5}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 342 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003266852. FT TRANSMEM 308 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 342 AA; 38843 MW; 6E9D9158DC5EB585 CRC64; MGPRTLLLLL LGVLVPRDTR AGPHSMRYFL TAVSRPGLGE PRFITVGYVD DTQFVRFDSD RPDPRMEPRA RWVEDEGPEY WDQETRIQKE NTQTFRANLN TLLGYYNQSE AGSHTIQWMH GCGVGSDGRL LRGYNQLAYD GKDYLALNED LRSWTAADTA AQITKRKWEA AGEAERFRNY LEGECVKLLR RHLENGKDTL LRADPPKAHV AHHPSSEREV TLRCWALGFY PEEISLTWQR NGEDQIQDME LVETRPSGDG TFQKWAALAV PSGEEQRYTC RVQHEGLQGP LTLRWGKGGE PPQPSVPIMG IILVLVLLVV AVVARAVIWS KKRTGEKGRI YT // ID F1PDJ7_CANLF Unreviewed; 315 AA. AC F1PDJ7; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 31-OCT-2012, sequence version 2. DT 12-SEP-2018, entry version 59. DE SubName: Full=Alpha-2-glycoprotein 1, zinc-binding {ECO:0000313|Ensembl:ENSCAFP00000021945}; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSCAFP00000021945, GN ECO:0000313|VGNC:VGNC:38327}; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000021945, ECO:0000313|Proteomes:UP000002254}; RN [1] {ECO:0000313|Ensembl:ENSCAFP00000021945, ECO:0000313|Proteomes:UP000002254} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000021945, RC ECO:0000313|Proteomes:UP000002254}; RX PubMed=16341006; DOI=10.1038/nature04338; RG Broad Sequencing Platform; RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., RA Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., RA Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F., RA Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., RA Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., RA Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., RA Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., RA Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., RA Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., RA Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., RA Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., RA Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., RA Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., RA Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., RA Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., RA Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., RA Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., RA Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., RA Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., RA Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., RA Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., RA Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., RA Marabella R., Maru K., Matthews C., McDonough S., Mehta T., RA Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., RA Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., RA Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., RA Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., RA Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., RA Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., RA Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., RA Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., RA Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., RA Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., RA Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., RA Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., RA Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.; RT "Genome sequence, comparative analysis and haplotype structure of the RT domestic dog."; RL Nature 438:803-819(2005). RN [2] {ECO:0000313|Ensembl:ENSCAFP00000021945} RP IDENTIFICATION. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000021945}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAEX03004276; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001274074.1; NM_001287145.1. DR UniGene; Cfa.11319; -. DR ProteinModelPortal; F1PDJ7; -. DR STRING; 9615.ENSCAFP00000021945; -. DR PaxDb; F1PDJ7; -. DR PRIDE; F1PDJ7; -. DR Ensembl; ENSCAFT00000023638; ENSCAFP00000021945; ENSCAFG00000014889. DR GeneID; 479739; -. DR KEGG; cfa:479739; -. DR CTD; 563; -. DR VGNC; VGNC:38327; AZGP1. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F1PDJ7; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Reactome; R-CFA-5223345; Miscellaneous transport and binding events. DR Proteomes; UP000002254; Chromosome 6. DR Bgee; ENSCAFG00000014889; Expressed in 2 organ(s), highest expression level in liver. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002254}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000002254}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 315 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003267499. FT DOMAIN 207 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 315 AA; 35855 MW; 713D5E23F4F7DEF6 CRC64; MDTIVSALLS LLLLLGPAVP QETQGGPYSL SFFYTGLSRP SDGFPSFQAT AYLNDQDFFH YDSETGKAIP RYPWSQMEGI EDWEKESKLQ KAREDIFMVT LKDIMEYYKD KEGSHTFQGM FGCELQNNKN SGAFWRYAYD GRNFIEFNKE IPAWVPQDPA ALNTKKKWEA EEVYVQRAKA YLEEECPVML QRYLEYGKTY LDRQEPPSVS ITSHGTPEGI QTLKCWVSGF YPQEIDLHWI QADDTQETKS GGALLPSGNN TYQAWVVMSA SPQDLASFSY SCLVKHSSLS QPLTVLWDKR QGAVRAEGSE DTQVQ // ID F1PE31_CANLF Unreviewed; 322 AA. AC F1PE31; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 31-OCT-2012, sequence version 2. DT 12-SEP-2018, entry version 52. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCAFP00000000727}; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000000727, ECO:0000313|Proteomes:UP000002254}; RN [1] {ECO:0000313|Ensembl:ENSCAFP00000000727, ECO:0000313|Proteomes:UP000002254} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000000727, RC ECO:0000313|Proteomes:UP000002254}; RX PubMed=16341006; DOI=10.1038/nature04338; RG Broad Sequencing Platform; RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., RA Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., RA Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F., RA Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., RA Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., RA Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., RA Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., RA Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., RA Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., RA Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., RA Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., RA Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., RA Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., RA Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., RA Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., RA Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., RA Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., RA Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., RA Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., RA Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., RA Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., RA Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., RA Marabella R., Maru K., Matthews C., McDonough S., Mehta T., RA Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., RA Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., RA Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., RA Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., RA Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., RA Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., RA Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., RA Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., RA Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., RA Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., RA Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., RA Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., RA Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.; RT "Genome sequence, comparative analysis and haplotype structure of the RT domestic dog."; RL Nature 438:803-819(2005). RN [2] {ECO:0000313|Ensembl:ENSCAFP00000000727} RP IDENTIFICATION. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000000727}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAEX03008212; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1PE31; -. DR STRING; 9615.ENSCAFP00000000727; -. DR PaxDb; F1PE31; -. DR PRIDE; F1PE31; -. DR Ensembl; ENSCAFT00000000791; ENSCAFP00000000727; ENSCAFG00000000492. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F1PE31; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Reactome; R-CFA-1236974; ER-Phagosome pathway. DR Reactome; R-CFA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-CFA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-CFA-6798695; Neutrophil degranulation. DR Reactome; R-CFA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002254; Chromosome 12. DR Bgee; ENSCAFG00000000492; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002254}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002254}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 293 320 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 282 IGc1. {ECO:0000259|SMART:SM00407}. SQ SEQUENCE 322 AA; 35612 MW; EEC1FE048D74E02E CRC64; MRVVMRGTPP PPPLLPSGAL AVTLTRAGSH SLRFFHTAVS RPGRGDPLYI SVGYVDDTQF VRFDSDAATG RMEPRAPWVE QEGPEYWDGE TRNLKETAQV YRVDLDTLRG YYNQSEAAGS HTIQTMYGCD LGPGGRLLRG YSQDAYDGAD YIALNEDLRS WTAADAAALI TRRKREAAGD AGHLRNYLET TCVEWLRRYL EMGKETLLRA GSPKGTLTHH PFSDCEVTLT CQDGEDQTQD TELVETRPAG DGTFQKWAAV VVPSGQEQRY TCHVQHEGLA EPVTRRWESP PRLTIPIVGI VAGLLVFVVS GTMVAGAVLW RK // ID F1PE32_CANLF Unreviewed; 392 AA. AC F1PE32; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 31-OCT-2012, sequence version 2. DT 12-SEP-2018, entry version 56. DE SubName: Full=MHC class I DLA-88 precursor {ECO:0000313|Ensembl:ENSCAFP00000000718}; GN Name=DLA88 {ECO:0000313|Ensembl:ENSCAFP00000000718}; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000000718, ECO:0000313|Proteomes:UP000002254}; RN [1] {ECO:0000313|Ensembl:ENSCAFP00000000718, ECO:0000313|Proteomes:UP000002254} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000000718, RC ECO:0000313|Proteomes:UP000002254}; RX PubMed=16341006; DOI=10.1038/nature04338; RG Broad Sequencing Platform; RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., RA Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., RA Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F., RA Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., RA Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., RA Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., RA Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., RA Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., RA Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., RA Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., RA Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., RA Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., RA Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., RA Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., RA Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., RA Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., RA Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., RA Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., RA Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., RA Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., RA Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., RA Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., RA Marabella R., Maru K., Matthews C., McDonough S., Mehta T., RA Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., RA Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., RA Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., RA Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., RA Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., RA Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., RA Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., RA Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., RA Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., RA Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., RA Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., RA Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., RA Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.; RT "Genome sequence, comparative analysis and haplotype structure of the RT domestic dog."; RL Nature 438:803-819(2005). RN [2] {ECO:0000313|Ensembl:ENSCAFP00000000718} RP IDENTIFICATION. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000000718}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAEX03008211; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1PE32; -. DR STRING; 9615.ENSCAFP00000000718; -. DR PaxDb; F1PE32; -. DR PRIDE; F1PE32; -. DR Ensembl; ENSCAFT00000000779; ENSCAFP00000000718; ENSCAFG00000000487. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F1PE32; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-CFA-1236974; ER-Phagosome pathway. DR Reactome; R-CFA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-CFA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-CFA-6798695; Neutrophil degranulation. DR Reactome; R-CFA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002254; Chromosome 12. DR Bgee; ENSCAFG00000000487; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002254}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002254}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 392 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003267295. FT TRANSMEM 307 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 392 AA; 43447 MW; B25F3ACCDDE703E7 CRC64; MEVVMPRALL VLLSAALAVT LTRAGSHSLR YFYTSVSRPG RGDPRFIAVG YVDDTQFVRF DSDAATGRME PRAPWVEQEG PEYWDGETRK VKETAQLYRV DLDTLRGYYN QSEAAGSHTI QTMYGCDLGP GGRLLRGYSQ DAYDGADYIA LNEDLRSWTA ADAAALITRR KREAAGDAGH LRNYLETTCV EWLRRYLEMG KETLLRAEPP STRVTRHPVS DREVTLRCWA LGFYPEEITL TWQRDGEDQT QDTEVVDTRP AGDGTFQKWA AVVVPSGQEQ RYTCHVQHEG LAEPVTRRWE PSPLSTIVIV SIAALVLLVV AGVIGAVIWR KQRSGGKGPG YSHAARDDSA QGSDVSLTAP RGETPETLKW GGLGHWEPAG SSLCSVSLLW KL // ID F1PEZ8_CANLF Unreviewed; 360 AA. AC F1PEZ8; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 31-OCT-2012, sequence version 2. DT 12-SEP-2018, entry version 55. DE SubName: Full=MHC class I DLA-12 precursor {ECO:0000313|Ensembl:ENSCAFP00000031424}; GN Name=DLA-12 {ECO:0000313|Ensembl:ENSCAFP00000031424}; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000031424, ECO:0000313|Proteomes:UP000002254}; RN [1] {ECO:0000313|Ensembl:ENSCAFP00000031424, ECO:0000313|Proteomes:UP000002254} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000031424, RC ECO:0000313|Proteomes:UP000002254}; RX PubMed=16341006; DOI=10.1038/nature04338; RG Broad Sequencing Platform; RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., RA Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., RA Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F., RA Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., RA Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., RA Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., RA Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., RA Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., RA Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., RA Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., RA Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., RA Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., RA Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., RA Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., RA Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., RA Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., RA Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., RA Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., RA Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., RA Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., RA Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., RA Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., RA Marabella R., Maru K., Matthews C., McDonough S., Mehta T., RA Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., RA Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., RA Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., RA Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., RA Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., RA Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., RA Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., RA Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., RA Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., RA Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., RA Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., RA Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., RA Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.; RT "Genome sequence, comparative analysis and haplotype structure of the RT domestic dog."; RL Nature 438:803-819(2005). RN [2] {ECO:0000313|Ensembl:ENSCAFP00000031424} RP IDENTIFICATION. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000031424}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAEX03008212; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9615.ENSCAFP00000031424; -. DR PaxDb; F1PEZ8; -. DR PRIDE; F1PEZ8; -. DR Ensembl; ENSCAFT00000036086; ENSCAFP00000031424; ENSCAFG00000032222. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F1PEZ8; -. DR OMA; SALTKTW; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-CFA-1236974; ER-Phagosome pathway. DR Reactome; R-CFA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-CFA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-CFA-6798695; Neutrophil degranulation. DR Reactome; R-CFA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002254; Chromosome 12. DR Bgee; ENSCAFG00000032222; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002254}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002254}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 360 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003271394. FT TRANSMEM 306 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 360 AA; 40142 MW; 8BB91AD8E3A5D299 CRC64; VWAMVPGTLA LLLSGALAVT LTRAGSHSLR YFYTSVSRPG RGDPRFIAVG YVDDTQFVRF DSDAATGRME PRARWMEQEG PEYWDRQTRT IKETARTFRV DLDTLRGYYN QSEAGSHTFQ WMFGCDLGPG GRLLRGYSQD AYDGADYIAL NEDLRSWTAA DAAALITRRK REAAGDAGHL RNYLETTCVE WLRRYLEMGK ETLLRAEPPS TRVTRHPVSD HEVTLRCWAL GFYPAEITLT WQRDGEDQTQ DTEVVDTRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL AEPVTRRWEP SPLSTIVIVS IAALVLLVVA GVIGAVIWRK QRSGGKGPGY SHAARDDSAQ GSDVSLTAPR // ID F1PPX2_CANLF Unreviewed; 365 AA. AC F1PPX2; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 31-OCT-2012, sequence version 2. DT 12-SEP-2018, entry version 60. DE SubName: Full=MHC class Ib precursor {ECO:0000313|Ensembl:ENSCAFP00000034373}; GN Name=DLA-79 {ECO:0000313|Ensembl:ENSCAFP00000034373}; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000034373, ECO:0000313|Proteomes:UP000002254}; RN [1] {ECO:0000313|Ensembl:ENSCAFP00000034373, ECO:0000313|Proteomes:UP000002254} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000034373, RC ECO:0000313|Proteomes:UP000002254}; RX PubMed=16341006; DOI=10.1038/nature04338; RG Broad Sequencing Platform; RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., RA Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., RA Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F., RA Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., RA Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., RA Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., RA Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., RA Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., RA Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., RA Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., RA Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., RA Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., RA Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., RA Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., RA Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., RA Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., RA Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., RA Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., RA Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., RA Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., RA Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., RA Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., RA Marabella R., Maru K., Matthews C., McDonough S., Mehta T., RA Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., RA Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., RA Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., RA Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., RA Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., RA Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., RA Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., RA Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., RA Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., RA Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., RA Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., RA Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., RA Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.; RT "Genome sequence, comparative analysis and haplotype structure of the RT domestic dog."; RL Nature 438:803-819(2005). RN [2] {ECO:0000313|Ensembl:ENSCAFP00000034373} RP IDENTIFICATION. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000034373}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAEX03011468; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005631105.1; XM_005631048.2. DR UniGene; Cfa.48639; -. DR PRIDE; F1PPX2; -. DR Ensembl; ENSCAFT00000038631; ENSCAFP00000034373; ENSCAFG00000008234. DR GeneID; 483594; -. DR CTD; 483594; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-CFA-1236974; ER-Phagosome pathway. DR Reactome; R-CFA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-CFA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-CFA-6798695; Neutrophil degranulation. DR Reactome; R-CFA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002254; Chromosome 18. DR Bgee; ENSCAFG00000008234; Expressed in 3 organ(s), highest expression level in prefrontal cortex. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002254}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002254}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003271909. FT TRANSMEM 314 337 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 215 301 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 41441 MW; 518D22B5D0C962BA CRC64; MPVMRPRTLL LLLLLLLLSG TLGLAQTSAG SHSLRFLNTV VSRPGHGEPR HWAVAYVDDT PFERFNSERE GRRPEPLVRW LEQEGPEYWE ERTLNSRTCT QVLRRTLNEV SQDYSNQSRT GSHTFQTITG CDVGPDGRFL RGYQRHAYDG LDYITLSEDL RSWIVEDPVA QITRRKWDAA TVAENRKNFL EGRCLEWLRR HLENGRETLQ RADPPKTSVT RRPISEHEVT LKCWALGFYP AEITLTWQRD GEDQTQDTEL VETRPGGDGT FQKWAAVVVP SGEEQRYTCH ILHKSLPKPI TLRWEPPPQS TIPIVSIIAG LVLLVITGAM LVGVVIWRKK HSGSAQDSQM SVMAPNEQAS CLVGL // ID F1PX48_CANLF Unreviewed; 364 AA. AC F1PX48; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 31-OCT-2012, sequence version 2. DT 12-SEP-2018, entry version 54. DE SubName: Full=Hemochromatosis {ECO:0000313|Ensembl:ENSCAFP00000016096}; GN Name=HFE {ECO:0000313|Ensembl:ENSCAFP00000016096, GN ECO:0000313|VGNC:VGNC:41671}; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000016096, ECO:0000313|Proteomes:UP000002254}; RN [1] {ECO:0000313|Ensembl:ENSCAFP00000016096, ECO:0000313|Proteomes:UP000002254} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000016096, RC ECO:0000313|Proteomes:UP000002254}; RX PubMed=16341006; DOI=10.1038/nature04338; RG Broad Sequencing Platform; RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., RA Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., RA Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F., RA Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., RA Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., RA Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., RA Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., RA Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., RA Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., RA Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., RA Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., RA Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., RA Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., RA Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., RA Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., RA Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., RA Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., RA Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., RA Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., RA Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., RA Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., RA Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., RA Marabella R., Maru K., Matthews C., McDonough S., Mehta T., RA Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., RA Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., RA Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., RA Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., RA Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., RA Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., RA Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., RA Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., RA Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., RA Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., RA Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., RA Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., RA Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.; RT "Genome sequence, comparative analysis and haplotype structure of the RT domestic dog."; RL Nature 438:803-819(2005). RN [2] {ECO:0000313|Ensembl:ENSCAFP00000016096} RP IDENTIFICATION. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000016096}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAEX03017606; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1PX48; -. DR STRING; 9615.ENSCAFP00000016096; -. DR PaxDb; F1PX48; -. DR Ensembl; ENSCAFT00000017387; ENSCAFP00000016096; ENSCAFG00000010925. DR VGNC; VGNC:41671; HFE. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F1PX48; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Reactome; R-CFA-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000002254; Chromosome 35. DR Bgee; ENSCAFG00000010925; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl. DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:Ensembl. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl. DR GO; GO:0030881; F:beta-2-microglobulin binding; IEA:Ensembl. DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0071281; P:cellular response to iron ion; IEA:Ensembl. DR GO; GO:0042446; P:hormone biosynthetic process; IEA:Ensembl. DR GO; GO:0098711; P:iron ion import across plasma membrane; IBA:GO_Central. DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IEA:Ensembl. DR GO; GO:1904283; P:negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:Ensembl. DR GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; IEA:Ensembl. DR GO; GO:1900121; P:negative regulation of receptor binding; IEA:Ensembl. DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; IEA:Ensembl. DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR GO; GO:1904434; P:positive regulation of ferrous iron binding; IEA:Ensembl. DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl. DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl. DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IEA:Ensembl. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; IEA:Ensembl. DR GO; GO:1900390; P:regulation of iron ion import; IEA:Ensembl. DR GO; GO:2000008; P:regulation of protein localization to cell surface; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002254}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002254}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 30 {ECO:0000256|SAM:SignalP}. FT CHAIN 31 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003269312. FT TRANSMEM 323 347 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 225 314 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 41284 MW; 2DF2398928F892D2 CRC64; MSPGARRARL LLLLLLLLLF LLLQLPTVAA QRRPPRSHSL RYLFMGASVP DLGLPLFEAR GYVDDQLFVS YSHESRRAEP RAQWVRTGAA SQLWLQLSQS LKGWDHMFIV DFWTIMDNHN HSKVTKLGVS SESHTLQVIL GCEVQEDNST TGFWKYGYDG QNHLEFCPET LDWRAAEPKA QATKLEWEVN KIRAKQNRAY LQRDCPEQLR QLLELGRGVL DRQVPPLVKM THHVTSAVTT LRCQALSFYP QNITMKWLKD RQPLDAEDVE PKDVLPNGDG TYQRWVALAV APGEEQRYTC QVEHPGLDQP LTASWEAPMS GTLVVGIISG IAVCIIVLFT GILFRILRKR QASRGAMGDY VLAE // ID F1Q8P0_DANRE Unreviewed; 371 AA. AC F1Q8P0; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 3. DT 12-SEP-2018, entry version 61. DE SubName: Full=MHC class I antigen ZFA transcript variant 1 {ECO:0000313|EMBL:AHA37394.1}; DE SubName: Full=Major histocompatibility complex class I ZFA {ECO:0000313|Ensembl:ENSDARP00000095791}; GN Name=mhc1zfa {ECO:0000313|EMBL:AHA37394.1, GN ECO:0000313|Ensembl:ENSDARP00000095791, GN ECO:0000313|ZFIN:ZDB-GENE-130206-9}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000095791, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000095791} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000095791}; RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000095791, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000095791, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [3] {ECO:0000313|EMBL:AHA37394.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24287892; DOI=10.1007/s00251-013-0748-z; RA Dirscherl H., Yoder J.A.; RT "Characterization of the Z lineage Major histocompatability complex RT class I genes in zebrafish."; RL Immunogenetics 66:185-198(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABZ01089980; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC607855; AHA37394.1; -; mRNA. DR Ensembl; ENSDART00000105021; ENSDARP00000095791; ENSDARG00000088022. DR ZFIN; ZDB-GENE-130206-9; mhc1zfa. DR GeneTree; ENSGT00740000114936; -. DR OMA; TENARWI; -. DR TreeFam; TF334519; -. DR Proteomes; UP000000437; Chromosome 3. DR Bgee; ENSDARG00000088022; Expressed in 13 organ(s), highest expression level in pharyngeal gill. DR ExpressionAtlas; F1Q8P0; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 371 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015290018. FT TRANSMEM 318 339 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 215 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 371 AA; 43401 MW; 98C2ABF86021D1FC CRC64; MIMDVKVLTL LCVFLLYGAL PLCRAEKHSL YYIYTGLSRP VDLPGIYEFS AMGLLDDRQI DSYNSREQRK IPKQQWMKEK MQEDYWEKGT QSRKSKEQWF NVNVHILMDR MRHNRLDLHV LQWRHGCEVE IKGSEVKFSK GIDEYGYDGE NFLAFDEAES QWVAPVEEAL PTKRKWDSVP ILNQYTKGYL EKECVDWLNK FREYANEELR NGSPPEVHVF AVKSISDKTK LKLTCLATGF YSKDTMLVIR RNRLPEKKTE STGVRPNHDQ TFQLRKSVEI EQDETDEYDC YMTHRTLKGP VIARWDGKCK DCLPNLNWIW VVAGAVLMLG VVALLLVLLK KKIIDLRQRL SGSQSPLYQI QADSESEDYN H // ID F1QEW6_DANRE Unreviewed; 269 AA. AC F1QEW6; U6BNA4; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 12-SEP-2018, entry version 57. DE SubName: Full=MHC class I antigen ZCA transcript variant 2 {ECO:0000313|EMBL:AHA37376.1}; DE SubName: Full=Major histocompatibility complex class I ZCA {ECO:0000313|Ensembl:ENSDARP00000039383}; GN Name=mhc1zca {ECO:0000313|EMBL:AHA37376.1, GN ECO:0000313|Ensembl:ENSDARP00000039383, GN ECO:0000313|ZFIN:ZDB-GENE-070424-4}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000039383, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000039383} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000039383}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000039383, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000039383, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [3] {ECO:0000313|EMBL:AHA37376.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24287892; DOI=10.1007/s00251-013-0748-z; RA Dirscherl H., Yoder J.A.; RT "Characterization of the Z lineage Major histocompatability complex RT class I genes in zebrafish."; RL Immunogenetics 66:185-198(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX005416; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC607836; AHA37376.1; -; mRNA. DR UniGene; Dr.77541; -. DR Ensembl; ENSDART00000039459; ENSDARP00000039383; ENSDARG00000069471. DR ZFIN; ZDB-GENE-070424-4; mhc1zca. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; CEGETHP; -. DR Proteomes; UP000000437; Chromosome 1. DR Bgee; ENSDARG00000069471; Expressed in 17 organ(s), highest expression level in muscle tissue. DR ExpressionAtlas; F1QEW6; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 269 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015290034. FT TRANSMEM 218 241 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 23 205 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 269 AA; 31198 MW; D550F6C7BF5F0936 CRC64; MAVLAVLFSA VMLLSVVSVR TEKHSLYYIY TALSRPVDQS GIYQFTAMGL LDDRQIDYYN NIDQKKIPKQ HWMKEKMQED YWEKGTQSRK SKEQWFNVNV NILMDRMRHN NSDLHVLQWR HGCEIEIQGN EHRFSKGIDE YSYDGRNFLS FDDAESQWVA PVDAALPTKR KWDNVPILNQ YTKGYLEKEC VDWLNKFREY GDQELRDGYG EYLSEPPIAI IAAIIGVLIL LVAIGVTVWI LKKKNIIGNK DEKRSMPNGS ANYGRGSSA // ID F1QLW2_DANRE Unreviewed; 358 AA. AC F1QLW2; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 12-SEP-2018, entry version 48. DE SubName: Full=Major histocompatibility complex class I ZAA {ECO:0000313|Ensembl:ENSDARP00000118368}; DE Flags: Fragment; GN Name=mhc1zaa {ECO:0000313|Ensembl:ENSDARP00000118368, GN ECO:0000313|ZFIN:ZDB-GENE-030916-1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000118368, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000118368} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000118368}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000118368, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000118368, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CU394254; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1QLW2; -. DR PaxDb; F1QLW2; -. DR Ensembl; ENSDART00000145890; ENSDARP00000118368; ENSDARG00000092162. DR ZFIN; ZDB-GENE-030916-1; mhc1zaa. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F1QLW2; -. DR OrthoDB; EOG090C09Y9; -. DR TreeFam; TF334519; -. DR Proteomes; UP000000437; Chromosome 3. DR Bgee; ENSDARG00000092162; Expressed in 15 organ(s), highest expression level in spleen. DR ExpressionAtlas; F1QLW2; baseline. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F1QLW2}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}. FT DOMAIN 259 353 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSDARP00000118368}. SQ SEQUENCE 358 AA; 41483 MW; AF5F152CD446A580 CRC64; XHRPESSLGK SPSAIFRCFP VVLFLRRKAE PPGKHTHFLS VMMSGGVASG ICALLCVFLL CGDLPSAQGE KHSLYYIYTG LSKPLDLPGI YEFSAMGLLD DRQIDSYNSE EQRKIPKQQW MKEKMQEDYW EKGTQSRKSK EQWFNVNVNI LMDRMRHNMS DLHILQWRTG CEVEIQGSEV KFSKGIDEYG YDGENFLSFD EAESQWVAPV KEALPTKRKW DNVPILNQYT KGYLEKECVD WLNKFREYAD EELRNGSSPD VYKLTKKSTK DETKLKLTCL ATGFYDKDVM LNIRRNCLPE DETESTGVRP NHDQTFQLRK SVEIKEDQID EYDCHLTHRT LKNPIIVTQV NFTPPVVE // ID F1R6J5_DANRE Unreviewed; 383 AA. AC F1R6J5; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 12-SEP-2018, entry version 68. DE SubName: Full=MHC class I antigen ZJA transcript variant 1 {ECO:0000313|EMBL:AHA37398.1}; DE SubName: Full=Major histocompatibility complex class I ZJA {ECO:0000313|Ensembl:ENSDARP00000096436}; GN Name=mhc1zja {ECO:0000313|Ensembl:ENSDARP00000096436, GN ECO:0000313|ZFIN:ZDB-GENE-130206-11}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000096436, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000096436} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000096436}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000096436, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000096436, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [3] {ECO:0000313|EMBL:AHA37398.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24287892; DOI=10.1007/s00251-013-0748-z; RA Dirscherl H., Yoder J.A.; RT "Characterization of the Z lineage Major histocompatability complex RT class I genes in zebrafish."; RL Immunogenetics 66:185-198(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CU394254; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC607866; AHA37398.1; -; mRNA. DR UniGene; Dr.113248; -. DR Ensembl; ENSDART00000105659; ENSDARP00000096436; ENSDARG00000074765. DR ZFIN; ZDB-GENE-130206-11; mhc1zja. DR GeneTree; ENSGT00740000114936; -. DR OMA; NTRICKA; -. DR TreeFam; TF334519; -. DR Proteomes; UP000000437; Chromosome 3. DR Bgee; ENSDARG00000074765; Expressed in 15 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 383 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015290155. FT TRANSMEM 326 346 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 215 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 383 AA; 44983 MW; 13B0884C460FF8C2 CRC64; MTSFDRSFTL LYLCLFHVIM SSFRAEKHSL YFIYTGLSRP VDLPGIYEFS AMGLLDDRQI DSYNSEEQRN IPKQQWMKEK MQEDYWENRT QSRKEKQLWF YDNVHLLIDR NRQSTSVLHV LQWRHGCEVE KQGNEHSFNK SIDEYGYDGE DFLYYDDAES RWVAPVEEAL PTKRKWDNLP ILNQYTKDYL EKECVDWLNK FREYADEELR KASPPDVFKL TRKSTKDETK LKLTCLATGF YPNDVMLNIR RYRVYLPEQE TISTGVRPNH DQTFQLSKSV EIKEDQIDNY DCSVSHRTFK QPIIIKWDGT DLDGIYTGHP PETVPVVIGS VLIFLAILGV VVFLVMKCGE QDSSSTDTTE CTSILLGFIA DHLNKELTEG ENW // ID F1R7X4_DANRE Unreviewed; 246 AA. AC F1R7X4; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 12-SEP-2018, entry version 41. DE SubName: Full=Major histocompatibility complex class I ZAA {ECO:0000313|Ensembl:ENSDARP00000121869}; DE Flags: Fragment; GN Name=mhc1zaa {ECO:0000313|Ensembl:ENSDARP00000121869, GN ECO:0000313|ZFIN:ZDB-GENE-030916-1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000121869, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000121869} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000121869}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000121869, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000121869, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CU394254; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSDART00000135595; ENSDARP00000121869; ENSDARG00000092162. DR ZFIN; ZDB-GENE-030916-1; mhc1zaa. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000000437; Chromosome 3. DR Bgee; ENSDARG00000092162; Expressed in 15 organ(s), highest expression level in spleen. DR ExpressionAtlas; F1R7X4; baseline. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}. FT DOMAIN 61 243 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSDARP00000121869}. FT NON_TER 246 246 {ECO:0000313|Ensembl:ENSDARP00000121869}. SQ SEQUENCE 246 AA; 28831 MW; 8BD62FB3BC1596C8 CRC64; XPSAIFRCFP VVLFLRRKAE PPGKHTHFLS VMMSGGVASG ICALLCVFLL CGDLPSAQGE KHSLYYIYTS LSKPLDLPGI YEFSAMGLLD DRQIDSYNSE EQRKIPKQQW MKEKMQEDYW EKGTWSRKSK EQWFNVNVHI LMERMRHNMS DLHILQWRHG CEVEIQGSEV KFSKGVSEYG YDGENLLYFD DAESRWVAPV EEALPTKRKW DNIPILNQYT KGYLEKECVD WLNKFREYAD EELRKA // ID E9LK24_PIG Unreviewed; 356 AA. AC E9LK24; F1RHV7; F1RHV9; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 12-SEP-2018, entry version 64. DE SubName: Full=IgG receptor FcRn large subunit p51 precursor {ECO:0000313|Ensembl:ENSSSCP00000003457}; DE SubName: Full=Neonatal Fc receptor {ECO:0000313|EMBL:ADU85975.1}; GN Name=FcRn {ECO:0000313|EMBL:ADU85975.1}; GN Synonyms=FCGRT {ECO:0000313|Ensembl:ENSSSCP00000003457}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|EMBL:ADU85975.1}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000003457, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000003457, RC ECO:0000313|Proteomes:UP000008227}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ADU85975.1} RP NUCLEOTIDE SEQUENCE. RA Liu Y., Zhang Q.; RT "Polymorphism identification and association of FcRn gene with immune RT traits in three pigs."; RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSSSCP00000003457} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [4] {ECO:0000313|Ensembl:ENSSSCP00000053999} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2017) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000041; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; HQ026019; ADU85975.1; -; Genomic_DNA. DR RefSeq; XP_013854089.1; XM_013998635.1. DR RefSeq; XP_013854090.1; XM_013998636.1. DR RefSeq; XP_013854091.1; XM_013998637.1. DR RefSeq; XP_013854093.1; XM_013998639.1. DR UniGene; Ssc.79722; -. DR UniGene; Ssc.93742; -. DR STRING; 9823.ENSSSCP00000003457; -. DR PRIDE; E9LK24; -. DR Ensembl; ENSSSCT00000003540; ENSSSCP00000003457; ENSSSCG00000003187. DR Ensembl; ENSSSCT00000003542; ENSSSCP00000003459; ENSSSCG00000003187. DR Ensembl; ENSSSCT00000046042; ENSSSCP00000053999; ENSSSCG00000003187. DR GeneID; 397399; -. DR CTD; 2217; -. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR TreeFam; TF336617; -. DR ChiTaRS; FCGRT; pig. DR Proteomes; UP000008227; Chromosome 6. DR Bgee; ENSSSCG00000003187; Expressed in 6 organ(s), highest expression level in lung. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; IBA:GO_Central. DR GO; GO:0019770; F:IgG receptor activity; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:E9LK24}; KW Receptor {ECO:0000313|EMBL:ADU85975.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 356 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015090344. FT TRANSMEM 301 322 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 356 AA; 39341 MW; 6D89423F7D622A22 CRC64; MRVPRPQPWW LALLLLLLPG TPRADNHRSL LYHLTAVSAP TPGAPAFWVS GWLGPQQYLS YNNLRAQAEP YGAWVWESQV SWYWEKETAD LRNKQKLFLE ALKTLEEGGP FTLQGLLGCE LGPDNVSVPV ATFALNGEEF MKFDTKLGTW DGEWPEARTI GSKWMQEPDA VNKEKTFLLY SCPHRLLGHL ERGRGNLEWK EPPSMRMKAR PGTAPGFSVL TCIAFSFYPP ELQLRFLRNG LAAGSGESDI GPNGDGSFHA WSSLTVKSGD EHHYCCVVQH AGLAQPLTVE LESPAKSSMP VVGIMVGFLL LLIVAGGGAL LWRRMRKGLP APWISFHGDD VGALLPTPDL AKDAES // ID F1RHV8_PIG Unreviewed; 264 AA. AC F1RHV8; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 2. DT 12-SEP-2018, entry version 55. DE SubName: Full=IgG receptor FcRn large subunit p51 precursor {ECO:0000313|Ensembl:ENSSSCP00000003458}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSSSCP00000003458}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000003458, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000003458, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000003458, RC ECO:0000313|Proteomes:UP000008227}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000003458} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSSSCP00000038139} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2017) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000041; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PRIDE; F1RHV8; -. DR Ensembl; ENSSSCT00000003541; ENSSSCP00000003458; ENSSSCG00000003187. DR Ensembl; ENSSSCT00000047611; ENSSSCP00000038139; ENSSSCG00000003187. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR ChiTaRS; FCGRT; pig. DR Proteomes; UP000008227; Chromosome 6. DR Bgee; ENSSSCG00000003187; Expressed in 6 organ(s), highest expression level in lung. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F1RHV8}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 264 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015090489. FT TRANSMEM 209 230 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 110 198 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 264 AA; 28995 MW; 67E133B82CBADB41 CRC64; MRVPRPQPWW LALLLLLLPG TPRADNHRSL LYHLTAVSAP TPGAPAFWVS GWLGPQQYLS YNNLRAQAEP YGAWVWESQV SWYWEKETAD LRNKQKLFLE ALKTLEEGEP PSMRMKARPG TAPGFSVLTC IAFSFYPPEL QLRFLRNGLA AGSGESDIGP NGDGSFHAWS SLTVKSGDEH HYCCVVQHAG LAQPLTVELE SPAKSSMPVV GIMVGFLLLL IVAGGGALLW RRMRKGLPAP WISFHGDDVG ALLPTPDLAK DAES // ID F1RNP2_PIG Unreviewed; 319 AA. AC F1RNP2; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 12-SEP-2018, entry version 58. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000008163}; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSSSCP00000008163}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000008163, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000008163, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000008163}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000008163} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000015; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1RNP2; -. DR PaxDb; F1RNP2; -. DR PeptideAtlas; F1RNP2; -. DR PRIDE; F1RNP2; -. DR Ensembl; ENSSSCT00000008382; ENSSSCP00000008163; ENSSSCG00000007642. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F1RNP2; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Reactome; R-SSC-5223345; Miscellaneous transport and binding events. DR Proteomes; UP000008227; Chromosome 3. DR Bgee; ENSSSCG00000007642; Expressed in 5 organ(s), highest expression level in liver. DR Genevisible; F1RNP2; SS. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F1RNP2}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 28 49 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 220 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 319 AA; 35744 MW; B07FAE7309F45EF0 CRC64; MGLFLGSHFF SVALCVFLCP CHTVLLTIPL LSAVFCSLFA GPYTLSFLYT GLSRPGKGFP SFQAMAYLND QPFFRYESDG RKAEPLGPWS QVEGMEDWEK ESELQKARED IFMATLRDIM DYYKDREGSH TFQGRFGCEL RNDQRQAAFW RYAYDGRDFI EFNKEIPAWV ALDPAAVNTK LKWEAEAVYV QRAKAYLEEE CPGMLRRYLE HGRGHLDHPP SVSITRHVAP GQNGTLKCLA YDFYPGRIGL RWTGAGGAQE AESGGDVLPS GNGSYQSWVV DRAPHSCHVE HSSLAQPLTV PWAGLQELRV GGNIGTPAQ // ID F1RTG6_PIG Unreviewed; 349 AA. AC F1RTG6; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 12-SEP-2018, entry version 53. DE SubName: Full=MHC class I antigen 7 precursor {ECO:0000313|Ensembl:ENSSSCP00000001485}; GN Name=SLA-6 {ECO:0000313|Ensembl:ENSSSCP00000001485}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000001485, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000001485, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000001485}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000001485} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PRIDE; F1RTG6; -. DR Ensembl; ENSSSCT00000001527; ENSSSCP00000001485; ENSSSCG00000001398. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-SSC-1236974; ER-Phagosome pathway. DR Reactome; R-SSC-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-SSC-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-SSC-6798695; Neutrophil degranulation. DR Reactome; R-SSC-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000008227; Chromosome 7. DR Bgee; ENSSSCG00000001398; Expressed in 6 organ(s), highest expression level in lung. DR ExpressionAtlas; F1RTG6; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F1RTG6}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 349 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012497438. FT TRANSMEM 302 326 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 349 AA; 39534 MW; 428E1D58F27A07F1 CRC64; MQVTEPRTLL LVLSGSLALT ETWAGSHSLR YLHILVSRPG HGSDLYSSVG FLDDTQFVRF SSDAANPRVE PRAPWMEQEG REYWDRQTDI AKEHSKASSS NLRVIIGNHN HSQSVAQLSL GIGCDVGSDG RILRGYEQFS YDGDDYIVLN EDLRSWTAIS TVAQIIRRKW EAEGVAEQYR AYLEIECVEW LRKYLEKGKD VLQRAVPPKT HVTRHPFYDN KVTLRCWALG FYPKEISLTW QRDGEDQTQD MELVETRPSG DGTFQKWAAL VVPSGEEQSY TCQVQHEGLQ EPLTLRWEPP PLSLNLIMIC IAVSVLVVTV LGTVIWRKRN SGGNRGNYVQ AASRQDPGL // ID F1RTG7_PIG Unreviewed; 232 AA. AC F1RTG7; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 3. DT 12-SEP-2018, entry version 55. DE SubName: Full=MHC class I antigen 7 precursor {ECO:0000313|Ensembl:ENSSSCP00000001484}; GN Name=SLA-6 {ECO:0000313|Ensembl:ENSSSCP00000001484}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000001484, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000001484, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000001484}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000001484} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; F1RTG7; -. DR PRIDE; F1RTG7; -. DR Ensembl; ENSSSCT00000001526; ENSSSCP00000001484; ENSSSCG00000001398. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-SSC-1236974; ER-Phagosome pathway. DR Reactome; R-SSC-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-SSC-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-SSC-6798695; Neutrophil degranulation. DR Reactome; R-SSC-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000008227; Chromosome 7. DR Bgee; ENSSSCG00000001398; Expressed in 6 organ(s), highest expression level in lung. DR ExpressionAtlas; F1RTG7; baseline and differential. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 232 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013311285. FT DOMAIN 142 228 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 232 AA; 26352 MW; 5FAB26D7A51A9AB1 CRC64; MQVTEPRTLL LVLSGSLALT ETWAGHLHHG PKDPRLEKGQ TRPQPLPVIG SHSLRYLHIL VSRPGHGSDL YSSVGFLDDT QFVRFSSDAA NPRVEPRAPW MEQEGREYWD RQTDIAKEHS KASSSNLRVI IGNHNHSQSV PPKTHVTRHP FYDNKVTLRC WALGFYPKEI SLTWQRDGED QTQDMELVET RPSGDGTFQK WAALVVPSGE EQSYTCQVQH EGLQEPLTLR WG // ID F1RTG8_PIG Unreviewed; 342 AA. AC F1RTG8; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 3. DT 12-SEP-2018, entry version 63. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000001482}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000001482, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000001482, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000001482}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000001482} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1RTG8; -. DR PeptideAtlas; F1RTG8; -. DR PRIDE; F1RTG8; -. DR Ensembl; ENSSSCT00000001524; ENSSSCP00000001482; ENSSSCG00000024161. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000008227; Chromosome 7. DR Bgee; ENSSSCG00000024161; Expressed in 5 organ(s), highest expression level in lung. DR ExpressionAtlas; F1RTG8; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 294 316 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 217 276 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 342 AA; 38388 MW; 4609F37EF73E0D29 CRC64; LLTCKRLLIL SPCYHSLRDV YTAVSRPGRR ETRSIAVGYV DDTQLMRFDS DAPNPRVELR PSWMEQQGPE YWDLNTRGVK DTAQTPAVNL NTLRRYFNQS EAGSHTLQWT YGCDAEPDGR LLRRYEQFAY DGEDFIALNE DLRSWTAADT AAQITKRKWE ASGEAERDRN YLPGTCVEWL SRHLEMGKDT LQRRDPPKTH VTRHPSSDLG VTLRCWEISL TWQREGQDQS QDMELVETRP SGDGTFQKWA ALVVPPGEEQ SYTCHVQHEG LQEPLTLRWG KEGPGGGPPC PVPIIGIIVG LVLVAEVVVA GIVIWWKKRS GREGSGDLSL LVSVGVSSPG GS // ID F1RTI3_PIG Unreviewed; 338 AA. AC F1RTI3; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 3. DT 12-SEP-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000001476}; GN Name=LOC100153163 {ECO:0000313|Ensembl:ENSSSCP00000001476}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000001476, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000001476, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000001476}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000001476} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_013833061.1; XM_013977607.1. DR PRIDE; F1RTI3; -. DR Ensembl; ENSSSCT00000001518; ENSSSCP00000001476; ENSSSCG00000001394. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G0ANY; -. DR Reactome; R-SSC-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000008227; Chromosome 7. DR Bgee; ENSSSCG00000001394; Expressed in 5 organ(s), highest expression level in lung. DR ExpressionAtlas; F1RTI3; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 271 291 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 172 252 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 338 AA; 37787 MW; 1BD70A7D8BF2BA70 CRC64; MAQDGSVQPT FFAEGRLDGQ AFLRRERGTV EPQGLWAKNL STETWRKETK DLKEKVEDLR KCLGEILGLQ KEKGGLHSLQ EIVSCEMGED SHPRGVRRLY YDGELLLSCG LETHGCTVPQ ASAQTLALEM EKTCDMDELS RHYWAHVRGE LCAKLQGYLK SWTSFTERTV PPAVTVTCSQ ALEGTDNLTC QAVSFSPQNI SVAWYQDEKA VSPDTQQSGG VLPDGNGTYQ TWVTLRVPQG EEQRFSCHVE HGGNHSVHAV PCGKAPGRHR WWIISGALTL VIFIVTWFCS YTKMTPLVLR HQESIELEDL QQSQVLTRTA SHQRPVFQPR AISSTEGA // ID F1RUD0_PIG Unreviewed; 338 AA. AC F1RUD0; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 4. DT 12-SEP-2018, entry version 57. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000001415}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000001415, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000001415, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000001415, RC ECO:0000313|Proteomes:UP000008227}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000001415} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSSSCP00000056219} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2017) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9823.ENSSSCP00000001415; -. DR PRIDE; F1RUD0; -. DR Ensembl; ENSSSCT00000001457; ENSSSCP00000001415; ENSSSCG00000001341. DR Ensembl; ENSSSCT00000053987; ENSSSCP00000056219; ENSSSCG00000001341. DR eggNOG; ENOG410J90V; Eukaryota. DR eggNOG; ENOG41117CA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F1RUD0; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008227; Chromosome 7. DR Bgee; ENSSSCG00000001341; Expressed in 5 organ(s), highest expression level in lung. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F1RUD0}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 281 304 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 183 269 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 141 161 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 338 AA; 38630 MW; E9658CC92656F671 CRC64; MSEAAPGVPA FTAFGVIDDQ PFIRYDNEEM KAKSCVQWLR EEPSYFNDET KIFTSRMKIF RLNLRNVQRY YNQTMENGLN KALEHKQTGP HTLQFNYGCE LQQDGRTSGH WQYGYDGADY LSLHLDPLQY TAATFIAQYT KQKWEADRNF IERDKNYLEK ECIVWLRRYL EFAGESLNRT DPPKTHVTRH PSSDLGVTLR CWALGFYPKE ISLNWQREGQ DQSQDMELVE TRPSGDGTFQ KWAALVVPPG EEQSYTCHVQ HEGLQEPLTL RWEPPQPPVP IVGIFVGLVL VLVAGAMVAG VVIWRKKRSA EKGGSYTQAA GRDSAQSSGV SLIKDPRV // ID F1RZ55_PIG Unreviewed; 299 AA. AC F1RZ55; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 3. DT 12-SEP-2018, entry version 50. DE SubName: Full=MHC class I antigen 7 precursor {ECO:0000313|Ensembl:ENSSSCP00000001307}; GN Name=SLA-6 {ECO:0000313|Ensembl:ENSSSCP00000001307}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000001307, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000001307, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000001307}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000001307} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; F1RZ55; -. DR PRIDE; F1RZ55; -. DR Ensembl; ENSSSCT00000001338; ENSSSCP00000001307; ENSSSCG00000001398. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-SSC-1236974; ER-Phagosome pathway. DR Reactome; R-SSC-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-SSC-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-SSC-6798695; Neutrophil degranulation. DR Reactome; R-SSC-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000008227; Chromosome 7. DR Bgee; ENSSSCG00000001398; Expressed in 6 organ(s), highest expression level in lung. DR ExpressionAtlas; F1RZ55; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F1RZ55}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 299 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012361676. FT DOMAIN 50 228 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 299 AA; 33973 MW; 29A221156E380419 CRC64; MQVTEPRTLL LVLSGSLALT ETWAGHLHHG PKDPRLEKGQ TRPQPLPVIG SHSLRYLHIL VSRPGHGSDL YSSVGFLDDT QFVRFSSDAA NPRVEPRAPW MEQEGREYWD RQTDIAKEHS KASSSNLRVI IGNHNHSQSE SHSFLWVSGC DVGSDGRILR GYEQFSYDGD DYIVLNEDLR SWTAISTVAQ IIRRKWEAEG VAEQYRAYLE IECVEWLRKY LEKGKDVLQR AGRRALPDLT SRWGSTSSWP NLKGRKNGLD IKTTGTCGFQ ILYQRTSEQL KDSVSRCGGC KKMSRRSLQ // ID F1RZ57_PIG Unreviewed; 355 AA. AC F1RZ57; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 3. DT 12-SEP-2018, entry version 62. DE SubName: Full=MHC class I antigen 7 precursor {ECO:0000313|Ensembl:ENSSSCP00000001305}; GN Name=SLA-6 {ECO:0000313|Ensembl:ENSSSCP00000001305}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000001305, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000001305, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000001305}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000001305} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1RZ57; -. DR PeptideAtlas; F1RZ57; -. DR PRIDE; F1RZ57; -. DR Ensembl; ENSSSCT00000001336; ENSSSCP00000001305; ENSSSCG00000001398. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-SSC-1236974; ER-Phagosome pathway. DR Reactome; R-SSC-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-SSC-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-SSC-6798695; Neutrophil degranulation. DR Reactome; R-SSC-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000008227; Chromosome 7. DR Bgee; ENSSSCG00000024161; Expressed in 5 organ(s), highest expression level in lung. DR ExpressionAtlas; F1RZ57; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 355 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012542354. FT TRANSMEM 271 294 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 259 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 355 AA; 40396 MW; DA70B74CD6CBD453 CRC64; MGPRALLLLL SGTLVLTQPW ARPHSLRYFY TAVSRPSRRD PRFSVVGYVD DTQFVRFDSN APNPREEPRT PWVELEGPEY CDRNTRIYKD TSQNFQVSLN VLRGYYNQSE AGSHTYQWLC GCYVARDGHL LRGYSQFAYD GADYIVLNED LRSWTAVGMA AQITRRKWEE ETVAEQSRAY LEVACVQSLH RYLANGKETL QRSDPPKTHV TRHPSSDNKV TLRCWALGFY PKEISLTWQQ EGQSYTCHVQ HEGLQESLTL RWDPPQPPVP IVGIIVGLVL VLVTGAVVTG VVIWRKKCSG GKVRKYQQAE RSSRSENSGV CSMPFKAETL EALSGKQLPY TRRTDQVTNI SLMAL // ID F1RZ59_PIG Unreviewed; 338 AA. AC F1RZ59; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 4. DT 12-SEP-2018, entry version 63. DE SubName: Full=MHC class I antigen 5 precursor {ECO:0000313|Ensembl:ENSSSCP00000001303}; GN Name=SLA-5 {ECO:0000313|Ensembl:ENSSSCP00000001303}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000001303, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000001303, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000001303}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000001303} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9823.ENSSSCP00000001303; -. DR PaxDb; F1RZ59; -. DR PeptideAtlas; F1RZ59; -. DR PRIDE; F1RZ59; -. DR Ensembl; ENSSSCT00000001334; ENSSSCP00000001303; ENSSSCG00000030767. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00900000141162; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008227; Chromosome 7. DR Bgee; ENSSSCG00000001231; Expressed in 6 organ(s), highest expression level in lung. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 251 269 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 170 232 IGc1. {ECO:0000259|SMART:SM00407}. SQ SEQUENCE 338 AA; 37300 MW; 1FEE41DCB911F414 CRC64; MGPRGRVSPS PPPGPHSLSY LFTSVSRPGR GEPRFIAVGC VDDTPLVRFD SDARKPRKEP RAWWIEQEGP EYWDEETRIS KDNSEASERR GPGSRSHTIQ SLFGCDVDQT DRTLRRRGLP RPERGPALLD RGDTAAQITK RKWETANVAE QERSYLQGRR AGIRGAGPPP SPLGRELPSH RERKRDQSQD MELVETRPSG DGTFQKWAAL VVPPGEEQSY TCHVQHEGLQ EPLTLRWDPA QTPRPHRGHH VGLVLVLVAG AMVAGAVIWR KKRSGEKGGS YTQATAHDSA QGSDVLLPMD PRASESVCVP MSIMRRGGDP GPVLPPMSPS HPDLCSLP // ID F1S1N0_PIG Unreviewed; 244 AA. AC F1S1N0; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 3. DT 12-SEP-2018, entry version 58. DE SubName: Full=MHC class I antigen 8 precursor {ECO:0000313|Ensembl:ENSSSCP00000001299}; GN Name=SLA-8 {ECO:0000313|Ensembl:ENSSSCP00000001299}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000001299, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000001299, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000001299}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000001299} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; F1S1N0; -. DR PRIDE; F1S1N0; -. DR Ensembl; ENSSSCT00000001330; ENSSSCP00000001299; ENSSSCG00000001396. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-SSC-1236974; ER-Phagosome pathway. DR Reactome; R-SSC-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-SSC-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-SSC-6798695; Neutrophil degranulation. DR Reactome; R-SSC-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000008227; Chromosome 7. DR Bgee; ENSSSCG00000001229; Expressed in 5 organ(s), highest expression level in liver. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F1S1N0}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}. FT DOMAIN 183 241 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 244 AA; 28981 MW; 71500919070E90CA CRC64; HSMRYFHTVV SRPGHGEPRY LEVGYVDDTQ FVRFDSEAQN PRMEPRAPWV EQEGQEYWDE ETQRAKDLVQ NFRRNLMILR GYYNQSETGS HTFQLTYGCE EESHGGPLHA HWQYAYDGED YITLNEDLSS WTAADMAARV TQRKWDKSRA HERFKSYLEG TCVEWLRRYL ENGREMLQRA DPPKAYVTCH PSSDNKVTLR CWALGFYPKE ISLTWRREGQ DQSQDSYTCH VKHEGLQEPL TLRW // ID F1S1N1_PIG Unreviewed; 361 AA. AC F1S1N1; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 4. DT 12-SEP-2018, entry version 59. DE SubName: Full=MHC class I antigen 2 precursor {ECO:0000313|Ensembl:ENSSSCP00000001298}; GN Name=LOC100513601 {ECO:0000313|Ensembl:ENSSSCP00000001298}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000001298, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000001298, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000001298}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000001298} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9823.ENSSSCP00000001298; -. DR PaxDb; F1S1N1; -. DR PeptideAtlas; F1S1N1; -. DR PRIDE; F1S1N1; -. DR Ensembl; ENSSSCT00000001329; ENSSSCP00000001298; ENSSSCG00000001229. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F1S1N1; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008227; Chromosome 7. DR Bgee; ENSSSCG00000001229; Expressed in 5 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F1S1N1}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 361 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012338912. FT TRANSMEM 304 327 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 361 AA; 40033 MW; C60E0607DF92B4B7 CRC64; MGPGALFLLL SGTLALTGTQ AGPHSLSYFY TAVSRPDRGD SRFIAVGYVD DTQFVRFDNY APNPRMEPRV PWIQQEGQDY WDEETRKVKD NAQTYGVGLN TLRGYYNQSE AGSHTLQSMF GCYLGPDGLL LHGYRQDAYD GADYIALNED LRSWTAADMA AQISKRKWEA ADAAEHWRSY LQGLCVESLR RYLEMGKDTL QRAEPPKTHV TRHPSSDLGV TLRCWALGFY PKEISLTWQR EGQDQSQDME LVETRPSGDG TFQKWAALVV PPGEEQSYTC HVQHEGLQEP LTLRWDPAQP PVPIVGIIVG LVLVLVAGAV VAGVVIWRKT RSGEKGGSYT QAAGSDSAQG SDVSLTKDPR V // ID F1S1N3_PIG Unreviewed; 296 AA. AC F1S1N3; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 3. DT 12-SEP-2018, entry version 60. DE SubName: Full=MHC class I antigen 7 precursor {ECO:0000313|Ensembl:ENSSSCP00000001296}; GN Name=SLA-6 {ECO:0000313|Ensembl:ENSSSCP00000001296}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000001296, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000001296, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000001296}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000001296} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; F1S1N3; -. DR PRIDE; F1S1N3; -. DR Ensembl; ENSSSCT00000001327; ENSSSCP00000001296; ENSSSCG00000001398. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-SSC-1236974; ER-Phagosome pathway. DR Reactome; R-SSC-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-SSC-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-SSC-6798695; Neutrophil degranulation. DR Reactome; R-SSC-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000008227; Chromosome 7. DR Bgee; ENSSSCG00000001398; Expressed in 6 organ(s), highest expression level in lung. DR ExpressionAtlas; F1S1N3; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 255 279 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 161 247 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 296 AA; 33325 MW; 06299C2443ACA038 CRC64; MPVRKFSDQP NSDPPQTGRM QVTEPRTLLL VLSGSLALTE TWAGHLHHGP KDPRLEKGQT RPQPLPVIGS HSLRYLHILV SRPGHGSDLY SSVGFLDDTQ FVRFSSDAAN PRVEPRAPWM EQEGREYWDR QTDIAKEHSK ASSSNLRVII GNHNHSQSVP PKTHVTRHPF YDNKVTLRCW ALGFYPKEIS LTWQRDGEDQ TQDMELVETR PSGDGTFQKW AALVVPSGEE QSYTCQVQHE GLQEPLTLRW EPPPLSLNLI MICIAVSVLV VTVLGTVIWR KRNSGGNRGN YVQAAS // ID F1S677_PIG Unreviewed; 337 AA. AC F1S677; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 3. DT 12-SEP-2018, entry version 51. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSSSCP00000016476}; GN Name=MR1 {ECO:0000313|Ensembl:ENSSSCP00000016476}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000016476, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000016476, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000016476}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000016476} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000070; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_003130402.1; XM_003130354.3. DR ProteinModelPortal; F1S677; -. DR STRING; 9823.ENSSSCP00000016476; -. DR PaxDb; F1S677; -. DR PRIDE; F1S677; -. DR Ensembl; ENSSSCT00000016929; ENSSSCP00000016476; ENSSSCG00000015540. DR GeneID; 100511275; -. DR KEGG; ssc:100511275; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F1S677; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008227; Chromosome 9. DR Bgee; ENSSSCG00000015540; Expressed in 6 organ(s), highest expression level in heart. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 291 316 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 196 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 337 AA; 39039 MW; 280A3F9165C1D1CA CRC64; MLPLITVLTV KHSDARTHSL RYFRLGISDP GHEMPEFISV GYVDSYPITT YDSVSRQKEP RAPWMAENLE PDHWERYTQL LRGWQQTFKA ELKQLQRHYN HSGLHTYQRM IGCELLEDGS TTGFLQYAYD GQDFIIFNKD TLSWMAVDNV AHITKQAWEA NWHELQYQKN WLEQECVAWL RRFLEYGKDT LQRTEPPLVR VYHKETVPGI TTLYCRAHGF YPPEISMTWM KNEEEMVQEM DYGDILPSGD GTYQTWVSVE LDSQSSDVYS CHVKHCGVHT VLQGARELET MLLVLKAGAG FIVPAIALAG VGILAWRRRP REQNGIIYLP TPAHDGR // ID F1S7V1_PIG Unreviewed; 183 AA. AC F1S7V1; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 3. DT 12-SEP-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000004429}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000004429, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000004429, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000004429}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000004429} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000001; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1S7V1; -. DR STRING; 9823.ENSSSCP00000004429; -. DR PaxDb; F1S7V1; -. DR PeptideAtlas; F1S7V1; -. DR PRIDE; F1S7V1; -. DR Ensembl; ENSSSCT00000004531; ENSSSCP00000004429; ENSSSCG00000004098. DR eggNOG; ENOG410JBPA; Eukaryota. DR eggNOG; ENOG411150N; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F1S7V1; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF339658; -. DR Reactome; R-SSC-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000008227; Chromosome 1. DR Bgee; ENSSSCG00000004098; Expressed in 3 organ(s), highest expression level in heart. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 183 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012836158. SQ SEQUENCE 183 AA; 20166 MW; 7DE572A1F66B013D CRC64; MSLTHTTGLL LLTLLLLLKP RKTLRYAHSL CLNLTQTAWC EVQGSMDTKP LLQYDSDSNQ VTASGPLGRG KWHQTLGEEG PWGRDDSVCG VAGAPRLQAK LCCQLEAERV TAASWHFSLD GQTALLLDAM DMNWTVVNPG ATGIKEQKLT VGDCGHWLRE FLGHWENVLE QEPTGNGAGV RRW // ID F1S7V3_PIG Unreviewed; 216 AA. AC F1S7V3; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 3. DT 12-SEP-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000004427}; GN Name=LOC100521998 {ECO:0000313|Ensembl:ENSSSCP00000004427}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000004427, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000004427, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000004427}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000004427} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000001; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9823.ENSSSCP00000004427; -. DR PaxDb; F1S7V3; -. DR PeptideAtlas; F1S7V3; -. DR PRIDE; F1S7V3; -. DR Ensembl; ENSSSCT00000004529; ENSSSCP00000004427; ENSSSCG00000004096. DR eggNOG; ENOG410JBPA; Eukaryota. DR eggNOG; ENOG411150N; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F1S7V3; -. DR OrthoDB; EOG091G0NI5; -. DR TreeFam; TF339658; -. DR Reactome; R-SSC-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000008227; Chromosome 1. DR Bgee; ENSSSCG00000004096; Expressed in 5 organ(s), highest expression level in kidney. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F1S7V3}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 216 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012994423. FT DOMAIN 29 197 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 216 AA; 23877 MW; 190F381BE62A16E3 CRC64; MSLARTTGLL LLTRLLLLEP GKTLRYAHSL CLDFAVTSQS RPGQPWCEVQ GSMDTKPLLQ YDSDSNQVTA SGPLGEEVNG TKAWRDLTGT LGGVGRELRM VLHVVNLGTE KTTGAPRLQA KLCCQLEAER VTAASWHFSL DGQTALLLDA MDMNWTVVNP GATGIKEQWQ KDQDLAEYFR KLAVGDCGHW LRDFLGHWEN VLEQEPTGNG AGVRRW // ID F5H7Q8_HUMAN Unreviewed; 351 AA. AC F5H7Q8; DT 28-JUN-2011, integrated into UniProtKB/TrEMBL. DT 28-JUN-2011, sequence version 1. DT 12-SEP-2018, entry version 66. DE SubName: Full=MHC class I polypeptide-related sequence B {ECO:0000313|Ensembl:ENSP00000442345}; GN Name=MICB {ECO:0000313|Ensembl:ENSP00000442345}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000442345, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000442345, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000442345} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSP00000477804} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL663061; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR788288; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001276089.1; NM_001289160.1. DR UniGene; Hs.731446; -. DR PRIDE; F5H7Q8; -. DR Ensembl; ENST00000538442; ENSP00000442345; ENSG00000204516. DR Ensembl; ENST00000619506; ENSP00000477804; ENSG00000231179. DR GeneID; 4277; -. DR UCSC; uc011dnm.3; human. DR CTD; 4277; -. DR EuPathDB; HostDB:ENSG00000204516.9; -. DR HGNC; HGNC:7091; MICB. DR OpenTargets; ENSG00000204516; -. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR ChiTaRS; MICB; human. DR GenomeRNAi; 4277; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204516; Expressed in 172 organ(s), highest expression level in blood. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Proteomics identification {ECO:0000213|MaxQB:F5H7Q8, KW ECO:0000213|PeptideAtlas:F5H7Q8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT DOMAIN 175 270 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 351 AA; 39182 MW; EA76C6D3184A3930 CRC64; MVLSQDGSVQ SGFLAEGHLD GQPFLRYDRQ KRRAKPQGQW AENVLGAKTW DTETEDLTEN GQDLRRTLTH IKDQKGGLHS LQEIRVCEIH EDSSTRGSRH FYYDGELFLS QNLETQESTV PQSSRAQTLA MNVTNFWKED AMKTKTHYRA MQADCLQKLQ RYLKSGVAIR RTVPPMVNVT CSEVSEGNIT VTCRASSFYP RNITLTWRQD GVSLSHNTQQ WGDVLPDGNG TYQTWVATRI RQGEEQRFTC YMEHSGNHGT HPVPSGKALV LQSQRTDFPY VSAAMPCFVI IIILCVPCCK KKTSAAEGPE LVSLQVLDQH PVGTGDHRDA AQLGFQPLMS ATGSTGSTEG T // ID F6KXZ0_CHLSB Unreviewed; 365 AA. AC F6KXZ0; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 42. DE SubName: Full=MHC class IA antigen {ECO:0000313|EMBL:AEE37115.1}; DE SubName: Full=Popy class I histocompatibility antigen, alpha chain E precursor {ECO:0000313|Ensembl:ENSCSAP00000004357}; GN Name=Chsa-A {ECO:0000313|EMBL:AEE37115.1}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|EMBL:AEE37115.1}; RN [1] {ECO:0000313|EMBL:AEE37115.1} RP NUCLEOTIDE SEQUENCE. RA Wiseman R.W., Tuscher J.J., Karl J.A., Schmitz J.E., Jasinska A.J., RA Freimer N.B., O'Connor D.H.; RT "Caribbean-origin African green monkeys exhibit restricted major RT histocompatibility complex (MHC) diversity."; RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004357, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCSAP00000004357} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC241496; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; HQ686146; AEE37115.1; -; mRNA. DR RefSeq; NP_001279007.1; NM_001292078.1. DR Ensembl; ENSCSAT00000006150; ENSCSAP00000004357; ENSCSAG00000008095. DR GeneID; 103221837; -. DR KEGG; csab:103221837; -. DR CTD; 103221837; -. DR GeneTree; ENSGT00760000118960; -. DR KO; K06751; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000029965; Chromosome 17. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014089797. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 41150 MW; B716B3689A55E826 CRC64; MAVMAPRTLL LVLSGVLALT QTRAGSHSMR YFYTYMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWVEQEG PEYWDRSTRI MKTETQMAPV GLRNLRGYYN QSEAGSHTYQ RMYGCDLGPD GRLLRGYHQL AYDGKDYIAL NEDLRSWTAA DLAAQNTQRK WEASGWVEQF RTYLEGECLE WLRRYLENGK ETLQRAEPPK THVTHHPVSD HETTLRCWAL GFYPAEITLT WQRDGEEQTQ DTELVETRPS GNGTFQKWAA VVVPSGKEQR YTCHVQHEGL REPLTLRWEP SSQSTIPIVG IIAGLVLLGA VVTGAVVAAV MWRRKSSDRK GGSYAQAASS DSAQGSDVSL TACKV // ID F6PGB0_MONDO Unreviewed; 267 AA. AC F6PGB0; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 23-MAY-2018, entry version 48. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000010764}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000010764, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000010764, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000010764} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6PGB0; -. DR STRING; 13616.ENSMODP00000010764; -. DR Ensembl; ENSMODT00000010977; ENSMODP00000010764; ENSMODG00000008651. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6PGB0; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002280; Chromosome 2. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IBA:GO_Central. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}. FT DOMAIN 171 259 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 267 AA; 31041 MW; C587A86862C0A361 CRC64; GASHPDLGLP SFMTLGYVDE HLFVFCDHES KAKSWGPWLT KEEDEFWVRL TQSLKGWDHM FIIDLWTIMD NHSQGQGSHI LQVILGCEFL VEDNRTRGFW KYGYDGQDYL TFHPDTMNWT ALQPEAQATK QEWEMNKIWA KQHRAYLERD CPKQLQRYLK IESEILNKKC PRLVRVTQHV TDEGVTTLRC QAQNFSPVNI TLSWLWDGKQ VTQGTELGDI HPSGDGTFQI MTVAITPGEE WRYACQVEHP GLDQPLIMTW EPSPSWT // ID F6PMH2_MONDO Unreviewed; 297 AA. AC F6PMH2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 12-SEP-2018, entry version 55. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000003567}; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSMODP00000003567}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000003567, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000003567, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000003567} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR RefSeq; XP_007472689.1; XM_007472627.2. DR ProteinModelPortal; F6PMH2; -. DR Ensembl; ENSMODT00000003644; ENSMODP00000003567; ENSMODG00000002928. DR GeneID; 103099957; -. DR KEGG; mdo:103099957; -. DR CTD; 563; -. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6PMH2; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002280; Chromosome 1. DR Bgee; ENSMODG00000002928; Expressed in 2 organ(s), highest expression level in liver. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 297 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003344141. FT DOMAIN 207 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 297 AA; 34462 MW; D24D023E8F0F6406 CRC64; MGLLTTVFLL LMFTGTTMLK ESGIRCYSLI YEDVARSHPR PGQSNFTNTG YLNGQVFYQY DSKNQRAVPS PPWDKVKGMH DWEKESQFQK RREDFVLDNM QNILDYYNDG NGSHIFQGRF GCKLCGDNFI KGFWKCQYDG RDFIEFNTDE KPSWIPLDPA AHMIKQRWEA SPGAVYRAKA YLEEECIGTL RRYIEYGKTH LRQLIPPTVK LSHNSSLEGN LTMKCLAHHF YPKEIELNWL WNGKVQEKKV GEIQPIGDGT YQTWITAEIP SSKKNSYSCH VVHESSFESL VVNWAKE // ID F6PRS3_MACMU Unreviewed; 345 AA. AC F6PRS3; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 50. DE SubName: Full=Hereditary hemochromatosis protein precursor {ECO:0000313|Ensembl:ENSMMUP00000034329}; GN Name=HFE {ECO:0000313|Ensembl:ENSMMUP00000034329}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000034329, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000034329, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034329, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000034329} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034329}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030466; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMMUT00000041296; ENSMMUP00000034329; ENSMMUG00000023733. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000023733; Expressed in 14 organ(s), highest expression level in liver. DR ExpressionAtlas; F6PRS3; baseline. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 345 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003344251. FT TRANSMEM 302 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 283 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 345 AA; 39892 MW; BD71EC069972F216 CRC64; MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGSSEQ DLGLSLFEAL GYVDDQLFVF YDHESRRVEP RTPWVSGRTS SQMWLQLSQS LKGWDHMFTV DFWTIMENHN HSKESHTLQV ILGCKMQEDN STEGFWKYGY DGQDHLEFCP DTLDWRAAEP RAWPTKLEWE RHKIRARQNR AYLERDCPVQ LQQLLELGRG VFDRPEGSES SNLPGTVTTL RCRALNYYPQ NITMKWLKDR QSMDAKEVEP KDVLPNGDGT YQGWITLTVP PGEEQRYTCQ VEHPGLDQPL LAFWEPSPSR TLVIGVISGI AVFVIILFIG ILFIILRKRQ TSRGVMGHYV LAERE // ID F6PSQ2_HORSE Unreviewed; 361 AA. AC F6PSQ2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 52. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000003033}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000003033, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000003033, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003033, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000003033} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003033}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6PSQ2; -. DR STRING; 9796.ENSECAP00000003033; -. DR PaxDb; F6PSQ2; -. DR Ensembl; ENSECAT00000004388; ENSECAP00000003033; ENSECAG00000000732. DR eggNOG; ENOG410IGE3; Eukaryota. DR eggNOG; ENOG41114P3; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6PSQ2; -. DR OMA; RREPWYL; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000000732; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 361 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003339448. FT TRANSMEM 306 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 361 AA; 40097 MW; 4BE627D91B072D87 CRC64; IRVMAPGTLL LLLSGALSLT EMWAGSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVGF DSDAASPRAE PRALWAKQEG PEYWEEQTRI AKEAAQTFRV SLNNLRGYYN QSEAGSHTLQ RMYGCDVGPE GHLLRGYWQE GYDGADYIAL NEDLRSWTAA DAVAQITRRK WEAAGEAARF RNYAQGECLE SLLRYLEIGK EALQRADPPK THVTHHPISD HEVTLRCWAL GFYPAEITLS WLRDGEDVTQ DIELVETRPS GDRTFQKWAA VVVPSGEEQR YTCRVQHEGL AEPITLRWGP PPESTILTVG IIVGLVLLGA VVTGVVIRRK KHSGEKGRGY AQAARSDSAQ GSDVSLKAGD T // ID F6QGC8_XENTR Unreviewed; 320 AA. AC F6QGC8; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000061810}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000061810, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000061810} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000061810}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000061810} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099317; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099318; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099319; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F6QGC8; -. DR STRING; 8364.ENSXETP00000061810; -. DR PaxDb; F6QGC8; -. DR Ensembl; ENSXETT00000061261; ENSXETP00000061810; ENSXETG00000032895. DR eggNOG; ENOG410ITUC; Eukaryota. DR eggNOG; ENOG4111EG6; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6QGC8; -. DR OMA; ISMENEC; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000032895; Expressed in 9 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 320 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003339871. FT TRANSMEM 293 315 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 198 281 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 320 AA; 36348 MW; 5AA03592DCAF7DD0 CRC64; MACYISLVFL LGFPAVYSGS YTLKYYITML STAYPGLPQY SVIAYVDDVR YGRYNSDTRH AEFLIQSLMV LSEHLDGLNK QAQLIEITQK ALMNFIMDSS NKTYDINHVF QTKAACVLHE DGTVDVYKEE ALDGKQLIVF DKETMEIVPA TGEAAVLAQW LNKQAYPKKY KISMENECTQ HLPLYLLYIK NYLDKKVPNV KLSGSESENG TELHCRVYGF YPRDVEVKWI KNGRDEIHSE EAAQILPNPD GTYQISVGVK PEGGATYSCH IDHSSLEKAL VVPFEKETKN SHITYILIAV GVIVLFLAFR LGFFYKKKVK // ID F6QNM2_HORSE Unreviewed; 207 AA. AC F6QNM2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000003249}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000003249, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000003249, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003249, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000003249} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003249}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6QNM2; -. DR PaxDb; F6QNM2; -. DR Ensembl; ENSECAT00000004684; ENSECAP00000003249; ENSECAG00000004706. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F6QNM2; -. DR OMA; WGKQLEM; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000002281; Chromosome 31. DR Bgee; ENSECAG00000004706; Expressed in 2 organ(s), highest expression level in prefrontal cortex. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}. FT DOMAIN 3 173 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 207 AA; 23836 MW; DA62FB896819752F CRC64; TDAHSLCYDF TILPKASPGQ SWCEAQGQVD EKTFLSYDCG SQEVKSLSLL GEEVKGTRAW QEQMETLRDV GDFLRQQLLD LKLEKYTDRD PLPLQGRMLC QCEANGRTRA SWQFGSQGQT FLLFDSENRT WKVLHPRGRQ MKERWESDRD VTEFFRKISM GDCRSWLESF LVHWEKMLET TASPTMAPAI AQSRATAVMP ITWVLAV // ID F6R4X4_HORSE Unreviewed; 362 AA. AC F6R4X4; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 48. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000022368}; GN Name=LOC100057920 {ECO:0000313|Ensembl:ENSECAP00000022368}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000022368, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000022368, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022368, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000022368} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022368}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6R4X4; -. DR STRING; 9796.ENSECAP00000022368; -. DR PaxDb; F6R4X4; -. DR Ensembl; ENSECAT00000026772; ENSECAP00000022368; ENSECAG00000024771. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6R4X4; -. DR OMA; FQRMIGC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000024771; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; F6R4X4; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003345290. FT TRANSMEM 307 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40736 MW; B3C0190634C06CA8 CRC64; MRGKGPPTFL LLLSGALTLT ENWAGESHSL RYFYTAVSRP GRGEPRFIAV GYVDDTQFVR FDSDAATPRM EPRAPWVEQA GPEYWEEQTR GIKDTAQSFR VGLNNLHSYY NQSEAGSHTL QEMYGCDMGP DGRLLRGYSQ YAYDGDDYIA LNEDLRSWTA ADTAAQITRR KWEAAGEAEI YRNYLEGRCV EWLLRYLEIG KETLQRAEPP KTYVTHHPIS DREVTLRCWA LGFYPAEITL TWQRDGEDLT QDKELVETRP AGDGTFQKWA AVVVPSGEEQ RYTCHVQHEG LPEPVTLRWE RLPQPTIPIV GIVAGLVLFV VTGAVMAGAV IWRKKCSGRG GVWSEFSRGD SAQGSKLSVK TG // ID F6R545_HORSE Unreviewed; 341 AA. AC F6R545; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000022360}; GN Name=LOC100057920 {ECO:0000313|Ensembl:ENSECAP00000022360}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000022360, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000022360, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022360, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000022360} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022360}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSECAT00000026764; ENSECAP00000022360; ENSECAG00000024771. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000024771; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; F6R545; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 341 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003345296. FT TRANSMEM 307 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 341 AA; 38612 MW; 794E3E937FA65C02 CRC64; MRGKGPPTFL LLLSGALTLT ENWAGESHSL RYFYTAVSRP GRGEPRFIAV GYVDDTQFVR FDSDAATPRM EPRAPWVEQA GPEYWEEQTR GIKDTAQSFR VGLNNLHSYY NQSEAGSHTL QEMYGCDMGP DGRLLRGYSQ YAYDGDDYIA LNEDLRSWTA ADTAAQITRR KWEAAGEAEI YRNYLEGRCV EWLLRYLEIG KETLQRAEPP KTYVTHHPIS DREVTLRCWA LGFYPAEITL TWQRDGEDLT QDKELVETRP AGDGTFQKWA AVVVPSGEEQ RYTCHVQHEG LPEPVTLRWE RLPQPTIPIV GIVAGLVLFV VTGAVMAGAV IWRKKCSGRK A // ID F6R7A7_MACMU Unreviewed; 246 AA. AC F6R7A7; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000001239}; GN Name=LOC694600 {ECO:0000313|Ensembl:ENSMMUP00000001239}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000001239, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000001239, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000001239, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000001239} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000001239}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03031936; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_001082656.2; XM_001082656.2. DR STRING; 9544.ENSMMUP00000001239; -. DR Ensembl; ENSMMUT00000001319; ENSMMUP00000001239; ENSMMUG00000029465. DR GeneID; 694600; -. DR KEGG; mcc:694600; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F6R7A7; -. DR KO; K07986; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000029465; Expressed in 10 organ(s), highest expression level in colon. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 246 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003340402. FT TRANSMEM 224 244 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 30 202 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 246 AA; 27588 MW; 81F675D7ED7230CC CRC64; MAAAATTKIL LCLLLLLLPS LWSRAGRADL HSLCYEITII PKFRPGRRWC AVQGQVDKKT FLHYDCGNKI VTPVSPLGKK LSVTKAWKAQ NPVLREVVDM LTEQLLDIQL ENYTPREPLT LQARVSCEQK AEGHRSGSWQ FGFDGQVFLL FDSENRMWTT VHPGARKMKE KWENDKDVTM SFHYISMGDC TRWLKDFLTG TDSTLEPSAG ASLTMSSGTT QLRATATTLI LCCLLIILCC FILAGI // ID F6RD44_ORNAN Unreviewed; 158 AA. AC F6RD44; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000013202}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000013202, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [2] {ECO:0000313|Ensembl:ENSOANP00000013202} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000013202}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6RD44; -. DR Ensembl; ENSOANT00000013205; ENSOANP00000013202; ENSOANG00000008306. DR GeneTree; ENSGT00900000141162; -. DR InParanoid; F6RD44; -. DR OMA; WKGILER; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF342059; -. DR Proteomes; UP000002279; Unplaced. DR Bgee; ENSOANG00000008306; Expressed in 6 organ(s), highest expression level in heart. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}. FT DOMAIN 4 157 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 158 AA; 18204 MW; 8033E09962F74C90 CRC64; PLFKLGPGVS EFTSVGYVDD VFDINGGQGR AEPRTPWIQD NEGQEYWDQE TEILRSGVQN FRVGLQNIMS YYNQSEEGSH TVQGMYGCQL LEDTTTGEGF MQYGYNGQDY IALDKAMLSW TAVDARALNT KRKWEDDGTI AKYRKHIRFM LVDFFRRE // ID F6RF06_BOVIN Unreviewed; 363 AA. AC F6RF06; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 50. DE SubName: Full=MHC class I heavy chain isoform 1 precursor {ECO:0000313|Ensembl:ENSBTAP00000031126}; GN Name=BOLA {ECO:0000313|Ensembl:ENSBTAP00000031126}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000031126, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000031126, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000031126, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000031126} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000031126}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02055406; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9913.ENSBTAP00000031126; -. DR PaxDb; F6RF06; -. DR Ensembl; ENSBTAT00000031167; ENSBTAP00000031126; ENSBTAG00000002069. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR OMA; SALTKTW; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000009136; Chromosome 23. DR Bgee; ENSBTAG00000002069; Expressed in 9 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 363 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003342150. FT TRANSMEM 307 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 363 AA; 41417 MW; B579F4BE3A47CA97 CRC64; QRMRVMRPRT LLLLLSGVLV LTETLAGSHS LRYFYTGVSR PGLGEPRFIA VGYVDDTQFV RFDSDAADPR TEPRVPWMEQ EGPEYWDRET RNLKDAAQTF RVNLNTLLGY YNQSEAGSHT LQWMYGCDVE PDGRFLRGYR QDAYDGRDYI ALNQDLRSWT AADTAAQITK RKWEAAGEAE RRRNYLEGRC VEWLRRYLEN GKDTLLRADP PKAHVTRHPS SDREVTLRCW ALGFYPEEIS LTWQHNGEDQ TQDMELVETR PSGDGTFQKW AALVVPSGEE QRYTCRVQHE GLREPLTLRW EPPQTSFLTM GIIVGLVVLV VAVVAGAVIW RKKHSGEKGR IYTQAASSDS AQGSDVSLTV PKV // ID F6RHP4_HORSE Unreviewed; 358 AA. AC F6RHP4; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000008517}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000008517, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000008517, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008517, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000008517} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008517}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6RHP4; -. DR PaxDb; F6RHP4; -. DR Ensembl; ENSECAT00000010960; ENSECAP00000008517; ENSECAG00000009368. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6RHP4; -. DR OMA; VTHHPVF; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000009368; Expressed in 3 organ(s), highest expression level in liver. DR ExpressionAtlas; F6RHP4; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 358 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003340736. FT TRANSMEM 306 325 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 358 AA; 39968 MW; 3C883A256D107A6B CRC64; MWVMEPRTFL LLLSGALTLT ETWAGSHSMR YFSTGVSPGR GEPRFIAVGY VDDTQFARFD SDAASPRMES RAPIEQAGPE YWERETRTRK NAQTFRVGLT NLRGYYIQSE TGSHTLQWMS GCDVGPDGRL LRGYSQDAYD GADYIALNED LRSWTAADTA AQITRRKLEA AGVAEDYRKY LEGPCVKWLL RYLENGTETL QRVEPPKTHV THHRVSDHEV TLRCWALGFY PAEITLSWQR DGEDMTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHKGLPEP VTRRWEPSSQ PTIPTVGLIA GLVLLAAVVT GAVICRRKRS GREGRSYTQA AGSDSAQGSD VSLMDPKG // ID F6RKI0_MONDO Unreviewed; 298 AA. AC F6RKI0; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000014281}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000014281, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000014281, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000014281} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6RKI0; -. DR Ensembl; ENSMODT00000014545; ENSMODP00000014281; ENSMODG00000011424. DR eggNOG; ENOG410IZF6; Eukaryota. DR eggNOG; ENOG41119ST; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6RKI0; -. DR OrthoDB; EOG091G0HHE; -. DR TreeFam; TF352056; -. DR Proteomes; UP000002280; Chromosome 1. DR Bgee; ENSMODG00000011424; Expressed in 1 organ(s), highest expression level in liver. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}. FT DOMAIN 179 260 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 298 AA; 33798 MW; ACFDBB9088426E3D CRC64; AHHRHDFYFT ATGSSGSFLD FIVNSVVDDV QLCSYHKEKH QLVMKEDWMY QALGASEIAQ KQQKLLDLEK NFQWAFKNLI KNEAKSGKNH TLQVFVNCEV DKDILVSSHF QFALDGEDFC QMDEQPEHWI AMKPEAQHFK FLWDSAFWKR RVRHYIQEDC IDGMNKVLQH SSMRENVPPE VTVSRYDAPD GRVTFSCRAT GFYPSSILLH WEKDGALGVW GQESSSGTLP NADATFYLQV TLELPPGDPG TGYICVVEHS ELETPAMFPV PGKPHMERPS VIAMSILAVI IVVLSCAG // ID F6RL31_MONDO Unreviewed; 259 AA. AC F6RL31; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000014272}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000014272, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000014272, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000014272} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6RL31; -. DR Ensembl; ENSMODT00000014536; ENSMODP00000014272; ENSMODG00000011414. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6RL31; -. DR OrthoDB; EOG090B0BJN; -. DR TreeFam; TF352056; -. DR Proteomes; UP000002280; Chromosome 1. DR Bgee; ENSMODG00000011414; Expressed in 6 organ(s), highest expression level in placenta. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}. FT DOMAIN 170 259 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 259 AA; 29762 MW; 414715CD9D87D1AD CRC64; HELQFIAVGT SQGLLELSAI AFIDDIQWAS YGKPLQQIKV KHAWISEALG RQFLKEMQYQ MTDQEEGYHR FIQHLTRNDR SKNHRTLQFY LNCELNEDIP LKYHVKYGFD GEDFIETNEK GKWKVLHHWA IGSEIFFESP AVFEQFNKIY CIGVMQKILQ KSSLKENRPP DMYVSHQEFP NGTITFSCTA TGFYPQAIQM SWKKADNGTV VGKEDSSGIL PNSDDTFYLQ ISLEVQPGEP RTGYACVVDH SQLEAPAVL // ID F6RN88_ORNAN Unreviewed; 222 AA. AC F6RN88; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000028190}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000028190, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [2] {ECO:0000313|Ensembl:ENSOANP00000028190} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000028190}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6RN88; -. DR Ensembl; ENSOANT00000031988; ENSOANP00000028190; ENSOANG00000004202. DR OrthoDB; EOG091G08B2; -. DR Proteomes; UP000002279; Unplaced. DR Bgee; ENSOANG00000004202; Expressed in 1 organ(s), highest expression level in testis. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 222 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003342372. FT DOMAIN 24 128 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 180 218 IGc1. {ECO:0000259|Pfam:PF07654}. SQ SEQUENCE 222 AA; 25030 MW; 84AED6106F6DB7BF CRC64; MEPLAFPMIL LFLPGGCTLP DSLHFFHYYF RVVSQPDPEL PVFMAVGYVD DQWFMRFGSL GQSAEAPSAW IREGRGLGYW KQQTQNLQDT VQIFLGNLQI SLSYYSQIEG GSQSYQETYG CQLQANGSPG GLHHPGLWHA YLSGGLPGAQ NTKWKWKANR NFTKSTWRGS ECIGSRHTCS TQSLSCQTCG FYPKEIKVKW QWDGMAMTQD PEHVETRPSG EG // ID F6RPN5_HORSE Unreviewed; 366 AA. AC F6RPN5; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 50. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000010079}; GN Name=LOC100050706 {ECO:0000313|Ensembl:ENSECAP00000010079}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010079, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000010079, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010079, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000010079} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010079}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR RefSeq; XP_005603768.1; XM_005603711.1. DR STRING; 9796.ENSECAP00000010079; -. DR PaxDb; F6RPN5; -. DR Ensembl; ENSECAT00000012758; ENSECAP00000010079; ENSECAG00000010913. DR GeneID; 100050706; -. DR KEGG; ecb:100050706; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6RPN5; -. DR KO; K06751; -. DR OMA; CEGETHP; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000010913; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003345928. FT TRANSMEM 306 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 41393 MW; 5C82BD02CBB48F08 CRC64; MRVTAPGTFL LLLSGALTLT ETWAGSHSLR YFKTAVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRME PRAPWMEQEG PQYWEEETRN YKDIAQNFRV ELNVLLDYYN LSKAGSHTFQ WMHGCYVDSD GHLLRGYSQF AYDGDDYLTL NEDLHSWTVA DMAAQITLHK WEASGVVERH KAYVKDKCVK WLLRHLENGK EMLQRIDPPK TQVTHHPISD HEVTLRCWAL GFYPAEITLT WQRDGEDLTQ DMELVETRPA GDRTFQKWAA VVVPSGEEQR YTCRVQHEGL PEPVILRWEP PLQSTITIVG IIVGLVLLGA VVTGAVVAGA VMWRKKRSGG KRGSYPQSTS GDSAQDSDVS LIPPKV // ID F6RRQ7_CALJA Unreviewed; 244 AA. AC F6RRQ7; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 29. DE SubName: Full=UL16 binding protein 3 {ECO:0000313|Ensembl:ENSCJAP00000024730}; GN Name=ULBP3 {ECO:0000313|Ensembl:ENSCJAP00000024730}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000024730, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000024730, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000024730} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6RRQ7; -. DR STRING; 9483.ENSCJAP00000024730; -. DR Ensembl; ENSCJAT00000026153; ENSCJAP00000024730; ENSCJAG00000013469. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F6RRQ7; -. DR OMA; GSLICER; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0046658; C:anchored component of plasma membrane; IEA:Ensembl. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IEA:Ensembl. DR GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 244 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015350925. SQ SEQUENCE 244 AA; 27850 MW; 1A1BD2A519412CA3 CRC64; MATTASLAFL LRPLLLFLLS GWRHAGWADS HSLWYNFTVI HLPRPGQRWC EVQGQVDQKN FLSYDCDSDK VLSVGCLEEQ LNATDAWGRQ LEMLSQVGQR LRLELPGIEL EDFTPSGPVM LQARMSCECE ADGHSKASWE FRFHGQKFLL FDSNSRKWTV VHAGARRMKE KWEEDRELTE LFGKVSIGDC RSWLRDFLIC REKRLEPTAS PTVTPGTAQP KSMATSLSPW SLLLILVCVT LYVI // ID F6RSN4_CALJA Unreviewed; 248 AA. AC F6RSN4; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000024727}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000024727, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000024727, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000024727} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSCJAT00000026150; ENSCJAP00000024727; ENSCJAG00000013455. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR Proteomes; UP000008225; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 248 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015317245. FT DOMAIN 33 201 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 248 AA; 27939 MW; E04FD3B3F9B14E25 CRC64; MAAAASSALR QCLPLLLLFQ LSGSSWAETA DPHSLCYDVT ITPKFRPGPR WCAVQGQLDQ KTFLHYDCGN KTVTPVSLLG KKINVTKSWK EQNPVLRELV DMLTEQLLGI QLQNYTPREP LTLQARMSCE QKAEGHSSGS WQFSFDGQIF LLFDSENRMW TTVHPGARKM KEKWENDKDM TMSFHYFSMG DCTRWLEDFL MGMDRTLESS TGAPPTMAPG TAQPKAMATT LSSWSLFIIL LCFILPGI // ID F6RUG7_HORSE Unreviewed; 348 AA. AC F6RUG7; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 53. DE SubName: Full=Hemochromatosis {ECO:0000313|Ensembl:ENSECAP00000022553}; GN Name=HFE {ECO:0000313|VGNC:VGNC:18766}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000022553, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000022553, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022553, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000022553} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022553}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9796.ENSECAP00000022553; -. DR PaxDb; F6RUG7; -. DR Ensembl; ENSECAT00000026969; ENSECAP00000022553; ENSECAG00000024981. DR VGNC; VGNC:18766; HFE. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6RUG7; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000024981; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl. DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:Ensembl. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl. DR GO; GO:0030881; F:beta-2-microglobulin binding; IEA:Ensembl. DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0071281; P:cellular response to iron ion; IEA:Ensembl. DR GO; GO:0042446; P:hormone biosynthetic process; IEA:Ensembl. DR GO; GO:0098711; P:iron ion import across plasma membrane; IBA:GO_Central. DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IEA:Ensembl. DR GO; GO:1904283; P:negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:Ensembl. DR GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; IEA:Ensembl. DR GO; GO:1900121; P:negative regulation of receptor binding; IEA:Ensembl. DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; IEA:Ensembl. DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR GO; GO:1904434; P:positive regulation of ferrous iron binding; IEA:Ensembl. DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl. DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl. DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IEA:Ensembl. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; IEA:Ensembl. DR GO; GO:1900390; P:regulation of iron ion import; IEA:Ensembl. DR GO; GO:2000008; P:regulation of protein localization to cell surface; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 348 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003342485. FT TRANSMEM 305 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 348 AA; 39596 MW; 159E768CD039EFE4 CRC64; MGPRARPALL FLILLRTVAT QGRPPRSHSL RYLFMGASEP DLGLPLFEAL GYVDDQLFVA YNHESRRAES RAQWVLGGAT SQLWLQLSQS LKGWDHMFIV DFWTIMDNHN HSKESHTLQV ILGCEVQEDN STRGFWKYGY DGQDHLEFCL ETLDWRAAES KAVTTKLEWE VNKIRAKKNK AYLERDCPEQ LQWLLELGRG VLDRQVPPLV KVTHHVASAV TFLRCQALNF YPQNITVRWL KDRQPVDAKD AESEDVLPNG DGTYQTWVAL AVTPGEEQRY TCQVEHPGLD QPLTATWEPS LSNTLAIGVI SVIAVCVIIF FTGILFRILR RRQASRGATG DYVLAECE // ID F6RWE4_ORNAN Unreviewed; 355 AA. AC F6RWE4; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 12-SEP-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000027555}; GN Name=LOC100086501 {ECO:0000313|Ensembl:ENSOANP00000027555}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000027555, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [2] {ECO:0000313|Ensembl:ENSOANP00000027555} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000027555}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR RefSeq; XP_001516609.3; XM_001516559.3. DR ProteinModelPortal; F6RWE4; -. DR STRING; 9258.ENSOANP00000027555; -. DR Ensembl; ENSOANT00000031355; ENSOANP00000027555; ENSOANG00000021638. DR GeneID; 100086501; -. DR KEGG; oaa:100086501; -. DR eggNOG; ENOG410IZF6; Eukaryota. DR eggNOG; ENOG41119ST; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6RWE4; -. DR KO; K06751; -. DR OrthoDB; EOG091G1OOS; -. DR TreeFam; TF352056; -. DR Proteomes; UP000002279; Unplaced. DR Bgee; ENSOANG00000021638; Expressed in 7 organ(s), highest expression level in female gonad. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 355 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003342514. FT TRANSMEM 312 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 355 AA; 40557 MW; 5E434042A3544FED CRC64; MEARRRLGFL ASFFCLLLGS PSLPQTLEDH HIGTMYLTAV RGDDGFFELT AITMLDGQKI ASYNSTDQEI VFGQNWLYQV LGRNLIQEMK SDLDISEMDF RWGMENWAQY QNHSRGSQTV QVIMGCELDR GVLVVSRYRF AYEREEMLRL DELKGAWMTT GQAKKQFGHF WEKRASWFQE TERYIREECP FLMRMILRFW HLRVHTPPEV TVTRRDVKDG RVIFTCLATG FFPSSILLRW VKDGEVGLWG EESSSGTLPN ADSSFYLRQT LEVREEAGDT GYSCVVEHST LELPTSNPAP EKPLWLMPWD QALGVMAASV LVLSPAVGII LWKKKKTDSG GQIAASEEGM SSFTT // ID F6S5E5_XENTR Unreviewed; 337 AA. AC F6S5E5; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000058545}; GN Name=mr1-like {ECO:0000313|Ensembl:ENSXETP00000058545}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000058545, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000058545} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000058545}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000058545} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099306; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099307; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099308; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099309; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 8364.ENSXETP00000058545; -. DR PaxDb; F6S5E5; -. DR Ensembl; ENSXETT00000060576; ENSXETP00000058545; ENSXETG00000034352. DR eggNOG; ENOG410ITUC; Eukaryota. DR eggNOG; ENOG4111EG6; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6S5E5; -. DR OMA; SCEVIHE; -. DR OrthoDB; EOG091G0FSD; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000034352; Expressed in 12 organ(s), highest expression level in skeletal muscle tissue. DR ExpressionAtlas; F6S5E5; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 337 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003346197. FT TRANSMEM 295 317 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 198 283 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 337 AA; 38178 MW; 83CFFFE792CC5A22 CRC64; MACYISLVFL LGFPAVYSGD HTLQFYVAVS STAYPGLLQY SIIAYVDDVR YGRYNSDTRR CESLIQSPMV FSEHLDGQTN MAQQTEITQK VLMNLIIDLL NKTHDINYVI QTKAACVLHE DGTVDVYEEV ALDGKELVVF DKERVEFVPA TQKAVLLAQW LNKQAFAMED KIFMENECTQ HLTLYLPYIK SYLDEKVPRV KLSSSESESG TELHCRVYGF YPRDVEVKWI KNGRDEIHSE EAAQILPNPD GTYQIRVSVG VTPEEGATYS CHIDHSSLEN PLIVPFETEI KNSHITYILI AVGVIVLFLA FGLGFFIQRK MKGLKGSRQS VSSEEQD // ID F6S6I3_MONDO Unreviewed; 318 AA. AC F6S6I3; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000014257}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000014257, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000014257, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000014257} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6S6I3; -. DR Ensembl; ENSMODT00000014521; ENSMODP00000014257; ENSMODG00000011403. DR eggNOG; ENOG410IZF6; Eukaryota. DR eggNOG; ENOG41119ST; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6S6I3; -. DR OrthoDB; EOG090B0BJN; -. DR TreeFam; TF352056; -. DR Proteomes; UP000002280; Chromosome 1. DR Bgee; ENSMODG00000011403; Expressed in 1 organ(s), highest expression level in female gonad. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 273 296 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 179 260 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 318 AA; 35973 MW; 21B769296C7B5A2C CRC64; GHHRLEGEFI AVGTRHSLFN FTIIHVIDDV LVCTYDKGNK QTVFNGAWIT RALGKDFTEN KKEFNLSAET YFRWLLSFFI KKDTKSNKNH TIQLYGECEL DNDIYIGSQI QFAVDGEDFI RTNDKMEHWI VTKPEAEHFR TIAESTLGVN LRKKVMKHYC AEMIRKILHY SNLKENVAPE VTVSRHDVSD GRVAFNCTAT GFYPRSIMMR WEKGGQLGVW GQESSSGTLP NADSTFYLQI TLELPPGDSG AGYACVVEHN KLQAPAVHPG ESWVLVLGLL TAIILVLSCS GAFILWNKKT GMYVRRQGEK TNCPSKRS // ID F6S7F4_HORSE Unreviewed; 156 AA. AC F6S7F4; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000003614}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000003614, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000003614, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003614, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000003614} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003614}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6S7F4; -. DR PaxDb; F6S7F4; -. DR Ensembl; ENSECAT00000005157; ENSECAP00000003614; ENSECAG00000005264. DR eggNOG; ENOG410JBPA; Eukaryota. DR eggNOG; ENOG411150N; LUCA. DR GeneTree; ENSGT00390000003472; -. DR OMA; SSRICSH; -. DR OrthoDB; EOG091G0NI5; -. DR TreeFam; TF339658; -. DR Proteomes; UP000002281; Chromosome 31. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}. FT DOMAIN 2 150 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 156 AA; 17878 MW; DD5F89FB56C14E03 CRC64; QGSVDRKPFL QYDSDSNMFR PLGLLGEKVN TTNAWTDLTQ TLGEVGQELR MVLPVIRLEK NRTRGKSSHP QVKLCCQREA GRYTGASWQF SINGQTAVFG TMRVNWTVID PGARGIQEEW ENSQDLAEHF RKLSAGDCSH WLREFLEHWE KVLEPT // ID F6SJC9_HORSE Unreviewed; 305 AA. AC F6SJC9; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000010282}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010282, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000010282, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010282, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000010282} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010282}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6SJC9; -. DR PaxDb; F6SJC9; -. DR Ensembl; ENSECAT00000012998; ENSECAP00000010282; ENSECAG00000012514. DR eggNOG; ENOG410J8UC; Eukaryota. DR eggNOG; ENOG4111ECF; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6SJC9; -. DR OMA; LVLQSHW; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF339076; -. DR Proteomes; UP000002281; Chromosome 10. DR Bgee; ENSECAG00000012514; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}. FT DOMAIN 180 266 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 305 AA; 34184 MW; CAC0ACDA182EE162 CRC64; THTLRYDLVA LAPGRPGKAQ FLALGYFDDE LFMRYDDESR RAEPRGLGIR TELRAETWER ETEDPIEKER QLRLTLAEIM GQQGQGQGLH SLQATLGCEL QRDSTRGFWR LGYNGQDILT FDSETLTWTV DAHSAQHIKK LWETRGPRAD LAKIFLYVTC PAQLWRYLAS WRGLLEKTVP LSVTVTHSKN LVGRIILRCR AFGFYPQDAT LTWLLDGEPM HQGTFGPRAI LPSGDGTYQT WVATRISPRE EQNFACHVGH HKLNITVPVV IGPQGRRAVH DAASAAAPLT VSAVVAALCL VVLEA // ID F6SJW9_ORNAN Unreviewed; 289 AA. AC F6SJW9; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000004195}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000004195, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [2] {ECO:0000313|Ensembl:ENSOANP00000004195} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000004195}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6SJW9; -. DR Ensembl; ENSOANT00000004196; ENSOANP00000004195; ENSOANG00000002636. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6SJW9; -. DR OMA; WMEREGR; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002279; Unplaced. DR Bgee; ENSOANG00000002636; Expressed in 6 organ(s), highest expression level in female gonad. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}. FT DOMAIN 176 265 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 289 AA; 31700 MW; 7DB8D66AEB0B9140 CRC64; SHWLRYFYTG VSRPGSGVSE FMSLGYVDDV QFVRFEGAPW IQDNEGQEYW DQNTQIFKGW AQMFPVGLRN IMGYYNQDKN GERGPGAWGS RLPRAPAMPG GGVGPTENGN NDNDNPLDDK SNSTFVVITL SSLGESNVTS AELILFPSSK PYLKLTSSER RSQTGKGGPV SPADPPEVEV TRHTGPDGED VSLRCRALGF YPADIKFKWE REGEDMSQEM EFVGTRPSGD GNFQKWASVN VPRGEERKYV CVVEHEGLGQ PLAVKWAPVP DASPPIAAIV GAVVVILLV // ID F6SNT0_MONDO Unreviewed; 291 AA. AC F6SNT0; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000014240}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000014240, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000014240, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000014240} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6SNT0; -. DR Ensembl; ENSMODT00000014504; ENSMODP00000014240; ENSMODG00000011387. DR eggNOG; ENOG410KEP1; Eukaryota. DR eggNOG; ENOG4111939; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6SNT0; -. DR OrthoDB; EOG091G0FSD; -. DR TreeFam; TF352056; -. DR Proteomes; UP000002280; Chromosome 1. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 263 286 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 162 252 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 291 AA; 33004 MW; AD258A6F611BC57B CRC64; LLELSGISFL DDVEVLSYNK AHKQIVFKIP WISKALGVKY LTELHDLLVK QEQDLRWTIE IVARNDTNHN RNHTAQLLAE CEIDNDILVK SHIHLIWDGE ECFRIDEEDG HWENVNPEFK QYQHILGSPL WTTLRKQYMK IYCVDGIRKI IGHSSIRDNV VPEVAVSQHV SPEGSIILSC IASGFYPRSI LMHWERNGKL GIWGNESSSG TLPNMDSTFY LKVTLELPPE DSGAGYTCVV EHSELKSPAI YSVPRKPTMN KSWILALGIT LAVILLLSCA GAFIIWKKKT G // ID F6T1I5_MOUSE Unreviewed; 379 AA. AC F6T1I5; DT 03-OCT-2012, integrated into UniProtKB/TrEMBL. DT 03-OCT-2012, sequence version 1. DT 12-SEP-2018, entry version 53. DE SubName: Full=Histocompatibility 2, T region locus 10 {ECO:0000313|Ensembl:ENSMUSP00000127602}; GN Name=H2-T10 {ECO:0000313|Ensembl:ENSMUSP00000127602, GN ECO:0000313|MGI:MGI:95942}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000127602, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000127602, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000127602, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000127602} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000127602}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CT030728; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F6T1I5; -. DR MaxQB; F6T1I5; -. DR PeptideAtlas; F6T1I5; -. DR PRIDE; F6T1I5; -. DR Ensembl; ENSMUST00000166442; ENSMUSP00000127602; ENSMUSG00000079491. DR MGI; MGI:95942; H2-T10. DR GeneTree; ENSGT00740000114936; -. DR HOVERGEN; HBG016709; -. DR InParanoid; F6T1I5; -. DR OMA; AICICLK; -. DR PhylomeDB; F6T1I5; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000079491; Expressed in 41 organ(s), highest expression level in smooth muscle tissue. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 379 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003346756. FT TRANSMEM 295 313 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 197 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 379 AA; 43204 MW; 0C52B55CCA9FB587 CRC64; MSWVLRAAVV CALLLQLDAR PSWTRIPLGS HSLRYFYTAV SRPGLGEPWF IIVGYVDDMQ VLRFSSKEET PRMAPWLEQE EADDWEQQTR IVTIQGQLSE RNLMTLVHFY NKSMDDSHTL QWLQGCDVEP DRHLCLWYNQ LAYDSEDLPT LSENPSSCTV GNSTVPQISQ HLEGHCSDLL QKYLEKGKER LLRSDPPKAH VTRHPRPEGD VTLRCWALGF YPADITLTWQ KDGEELTQEV EFVETRPAGD GTFQKWAAVV VPLGKVQSYT CHVDHEGLPE PLTLRWEPAW YQKPWIWIVA TVFSILLICL CVARRPMKKN AGGRGRRDTQ EAGRDSPQDS SKTVVDDEEM GVCFWKIKYC KTCLGHSPGT SVGESLLSP // ID F6TGU9_ORNAN Unreviewed; 223 AA. AC F6TGU9; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000005392}; GN Name=LOC100078249 {ECO:0000313|Ensembl:ENSOANP00000005392}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000005392, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [2] {ECO:0000313|Ensembl:ENSOANP00000005392} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000005392}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9258.ENSOANP00000005392; -. DR Ensembl; ENSOANT00000005393; ENSOANP00000005392; ENSOANG00000003398. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6TGU9; -. DR OMA; VEHESLL; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002279; Unplaced. DR Bgee; ENSOANG00000003398; Expressed in 6 organ(s), highest expression level in female gonad. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 194 217 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 96 185 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 223 AA; 24805 MW; 0116008D0507387F CRC64; GSHTFQWMYG CQLREDDTPG QGFVQLGYDG RDYVALDKAT LSWTAADAGA LNTKRKWEVD RTEAERWKAY LEGRCIDGLR RYLGFGGPSL TRADPPEVEV TRHTGPDGED VSLRCRALGF YPADIKFKWE REGKDMSQEM EFVGTRPSGD GNFQKWASVN VPRGEEQKYV CVVEHEGLAQ PLAVKWVPDP SPPIAAIVGA VVVILLVTAA VVGFVIWKRK KSG // ID F6TIX5_MOUSE Unreviewed; 340 AA. AC F6TIX5; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 12-SEP-2018, entry version 56. DE SubName: Full=H-2 class I histocompatibility antigen, TLA(B) alpha chain {ECO:0000313|Ensembl:ENSMUSP00000025312}; GN Name=H2-T3 {ECO:0000313|Ensembl:ENSMUSP00000025312, GN ECO:0000313|MGI:MGI:95959}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000025312, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000025312, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000025312, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000025312} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000025312}; RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CT030728; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F6TIX5; -. DR SMR; F6TIX5; -. DR MaxQB; F6TIX5; -. DR PeptideAtlas; F6TIX5; -. DR PRIDE; F6TIX5; -. DR Ensembl; ENSMUST00000025312; ENSMUSP00000025312; ENSMUSG00000054128. DR MGI; MGI:95959; H2-T3. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000054128; Expressed in 15 organ(s), highest expression level in colon. DR ExpressionAtlas; F6TIX5; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:F6TIX5, KW ECO:0000213|PeptideAtlas:F6TIX5}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 340 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003342533. FT TRANSMEM 271 290 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 167 255 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 38413 MW; 0D1AD8B15ECE0B4F CRC64; MRMGTMVPGT LLILLAASQG QTQTCPGSHS LRYFYTALSR PAISEPWYIA VGYLDDTQFV RFNSSGETAT YKLSAPWVEQ EGPEYWARET EIVTSNAQFF RENLQTMLDY YNLSQNAADT AAEITRSKWE QAGYTELRRT YLEGPCKDSL LRYLENRKKT QECTDPPKTH VTHHPRPEGY VTLRCWALRF YPADITLTWQ LNGEELIQDT ELVETRPAGD GTFQKWAAVV VPLGKEQKYT CHVYHEGLPE PLTLRWEPPQ TSMPNRTTVR ALLGAMIILG FMSGSVMMWM RKNNGGNGDD NTAAYQNERE HLSLSPRAES EALGVEAGMK DLPSAPPLVS // ID F6TK96_HORSE Unreviewed; 282 AA. AC F6TK96; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000020515}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020515, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000020515, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020515, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000020515} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020515}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6TK96; -. DR STRING; 9796.ENSECAP00000020515; -. DR PaxDb; F6TK96; -. DR Ensembl; ENSECAT00000024683; ENSECAP00000020515; ENSECAG00000022961. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6TK96; -. DR OMA; CVPCCKK; -. DR OrthoDB; EOG091G0EA5; -. DR TreeFam; TF342166; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000022961; Expressed in 3 organ(s), highest expression level in prefrontal cortex. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}. FT DOMAIN 186 276 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 282 AA; 31485 MW; EBD44E556B0675DA CRC64; SPSLLYNLTV VSHHGSVQPR FFGDGYLDGQ PFLHYDSEKG RAEPRGLWAG TVLGAETWNT ETKDLTEKGK DLKMTLADIL ALQDQKGDFH SLQEIWGCEI QEDNSARGLW HFCYDGELFL SYNPKTNEWT VAKSSAQTQA VEIKRSYEAD GFQSQDYRAR VQGELCGRLR IYSKSWMGFI HRTVPPAVNV TRTQASGGMV NLTCWAFGFS PRNISVTWLQ DEEPLSQDAQ QSGAVLPDGN GTYQTWVAIS IPQGEEQRFM CHVEHSGTHT AHPVLSGEPG VL // ID F6TQV3_XENTR Unreviewed; 337 AA. AC F6TQV3; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000058304}; GN Name=mr1 {ECO:0000313|Ensembl:ENSXETP00000058304}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000058304, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000058304} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000058304} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099317; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F6TQV3; -. DR STRING; 8364.ENSXETP00000058304; -. DR PaxDb; F6TQV3; -. DR Ensembl; ENSXETT00000065162; ENSXETP00000058304; ENSXETG00000033504. DR eggNOG; ENOG410ITUC; Eukaryota. DR eggNOG; ENOG4111EG6; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6TQV3; -. DR OMA; DEGHEYT; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000033504; Expressed in 9 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 337 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003343519. FT TRANSMEM 295 317 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 198 283 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 337 AA; 38247 MW; 85FCAE998EB2E4D6 CRC64; MACYISLVFL LGFPAVYSGS HTLKYYITML STAYPGLPQY SVIAYVDDVR YGRYNSDTRH AEFLIQSLMV FSEHSEGLNK QAQLIETMQK AIMNFIMDSS NMTYDINYVF QIQAACVLHE DGTVDVYEEG ALDGKQLVVF DKETVEFVPV TREAVLLAQW VNKQAFAKKY KILMENRCTQ HLTLYLPYIK SYLDEKVPRV KLSSSESESG TKLHCRVYGF YPRDVEVKWI KNGRDEIHSE EAAQILPNPD GTYQIRVSVG VTPEGGATYS CHIDHSSLEN PLVVLFETET KNSNITYILI AVGVIVLFLA FGLGFFIQRK MKGFKDSQQS ASTNEQE // ID F6TRT7_HORSE Unreviewed; 358 AA. AC F6TRT7; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 48. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000018443}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000018443, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000018443, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018443, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000018443} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018443}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR PaxDb; F6TRT7; -. DR Ensembl; ENSECAT00000022326; ENSECAP00000018443; ENSECAG00000020384. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6TRT7; -. DR OMA; SCEVIHE; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000020384; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 358 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003342723. FT TRANSMEM 306 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 358 AA; 39861 MW; D5487B0D93924EF6 CRC64; MRITAPGTLL LLLSGALTLT ETWAGSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRVE PRAPWVEQEG PEYWEEQTQS IKDHAQSFRT RLNTVRGYYN QSEAGSHTLQ WMYGCDVGPD GRLLRVYGQS AYDGADYLAL NEDLRTWTAA DAVAQISKRE CEAAGGAKYW KNYLEGTCVE RILRYLENGK EMLQRADPPK TQVTYHPISD HEVTLRCWAL GFYPAEITLS WQRDGEDLTQ DTEFVETRPA GDGTFQKWVA VVVPSGEEQT YTCRVQHEGL PEPVTLRWEP LPQPTIPIIC LIAGLVLLGA VVAGVVMWMK KCSGGKGTSY VVAASSDSAQ VSDVSLKA // ID F6TW19_MONDO Unreviewed; 47 AA. AC F6TW19; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000031502}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000031502, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000031502, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000031502} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 13616.ENSMODP00000031502; -. DR Ensembl; ENSMODT00000033075; ENSMODP00000031502; ENSMODG00000023744. DR GeneTree; ENSGT00870000137161; -. DR InParanoid; F6TW19; -. DR Proteomes; UP000002280; Chromosome 2. DR Bgee; ENSMODG00000023744; Expressed in 4 organ(s), highest expression level in liver. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}. FT DOMAIN 1 47 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 47 AA; 5382 MW; 4927AB583802BAE0 CRC64; LETLQGLYNQ SEGGIHILQK MFGCEVSANG NFRRGFKRFA YDGHDYL // ID F6TW33_MONDO Unreviewed; 54 AA. AC F6TW33; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000031501}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000031501, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000031501, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000031501} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSMODT00000033074; ENSMODP00000031501; ENSMODG00000023743. DR GeneTree; ENSGT00870000137161; -. DR InParanoid; F6TW33; -. DR Proteomes; UP000002280; Chromosome 2. DR Bgee; ENSMODG00000023743; Expressed in 5 organ(s), highest expression level in liver. DR ExpressionAtlas; F6TW33; baseline. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}. FT DOMAIN 1 54 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 54 AA; 6391 MW; 9A63C9285DB9FADC CRC64; AQFYRVDLET LRGYFNQSEE GVHTLQRLFG CEVSPDGSFK RSFYQYGYDG HDYL // ID F6U0H7_HUMAN Unreviewed; 246 AA. AC F6U0H7; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 50. DE SubName: Full=HLA class I histocompatibility antigen, B-46 alpha chain {ECO:0000313|Ensembl:ENSP00000405931}; DE Flags: Fragment; GN Name=HLA-B {ECO:0000313|Ensembl:ENSP00000405931}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000405931, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000405931, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000405931} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL671883; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F6U0H7; -. DR SMR; F6U0H7; -. DR MaxQB; F6U0H7; -. DR PeptideAtlas; F6U0H7; -. DR PRIDE; F6U0H7; -. DR Ensembl; ENST00000434333; ENSP00000405931; ENSG00000234745. DR UCSC; uc063nag.1; human. DR EuPathDB; HostDB:ENSG00000234745.9; -. DR HGNC; HGNC:4932; HLA-B. DR OpenTargets; ENSG00000234745; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR ChiTaRS; HLA-B; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000234745; Expressed in 92 organ(s), highest expression level in blood. DR ExpressionAtlas; F6U0H7; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:F6U0H7, KW ECO:0000213|PeptideAtlas:F6U0H7}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 36 214 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 246 246 {ECO:0000313|Ensembl:ENSP00000405931}. SQ SEQUENCE 246 AA; 27820 MW; 506FFC5202995696 CRC64; MASAGRSEGT AGGGAGPEEP RREEGRAGLS PSSPPGSHSM RYFYTSVSRP GRGEPRFISV GYVDDTQFVR FDSDAASPRE EPRAPWIEQE GPEYWDRNTQ IYKAQAQTDR ESLRNLRGYY NQSEAGSHTL QSMYGCDVGP DGRLLRGHDQ YAYDGKDYIA LNEDLRSWTA ADTAAQITQR KWEAAREAEQ RRAYLEGECV EWLRRYLENG KDKLERADPP KTHVTHHPIS DHEATLRCWA LGFYPA // ID F6U4H5_MACMU Unreviewed; 292 AA. AC F6U4H5; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000019505}; GN Name=LOC106995876 {ECO:0000313|Ensembl:ENSMMUP00000019505}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000019505, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000019505, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000019505, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000019505} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000019505}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030517; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMMUT00000020848; ENSMMUP00000019505; ENSMMUG00000029875. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000029875; Expressed in 13 organ(s), highest expression level in CD4-positive helper T cell. DR ExpressionAtlas; F6U4H5; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 292 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008955731. FT TRANSMEM 214 240 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 25 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 252 267 MHC_I_C. {ECO:0000259|Pfam:PF06623}. SQ SEQUENCE 292 AA; 32489 MW; A4581216450E9B90 CRC64; MAVMAPRTLL LVLSGVLALT QTQAGSHSMR YFYTAVSRPG RREPLFIAVG YVDDTQFVRF DSDAESPRME PRAPWVEQEG PEYWDRETQN MKTATQTYRG NLRTALRYYN QSEGGSHTIQ KMYGCDLGPD GRLLRGYEQF AYDGRDYIIL NEDLRSWTAA DMAAQFTQRK WEAARAAEQH RTYLEGECLE WLRRYLENGK ETLQRAEPFS QSTIPIVGII AGLVLLGTVV TGAVVAAVMW RRKSSGEEGV RSSDSSQGSD VSLTACKGET LGGLMCGGCW GNSGRSCAVG FL // ID F6U8V3_MOUSE Unreviewed; 335 AA. AC F6U8V3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 53. DE SubName: Full=Histocompatibility 2, M region locus 11 {ECO:0000313|Ensembl:ENSMUSP00000042522}; DE Flags: Fragment; GN Name=H2-M11 {ECO:0000313|Ensembl:ENSMUSP00000042522, GN ECO:0000313|MGI:MGI:2676637}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000042522, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000042522, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000042522, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000042522} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000042522}; RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR974472; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; F6U8V3; -. DR STRING; 10090.ENSMUSP00000042522; -. DR PaxDb; F6U8V3; -. DR PRIDE; F6U8V3; -. DR Ensembl; ENSMUST00000041964; ENSMUSP00000042522; ENSMUSG00000037537. DR MGI; MGI:2676637; H2-M11. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6U8V3; -. DR OrthoDB; EOG091G1MMC; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000037537; Expressed in 7 organ(s), highest expression level in colon. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 335 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003343013. FT TRANSMEM 307 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 335 335 {ECO:0000313|Ensembl:ENSMUSP00000042522}. SQ SEQUENCE 335 AA; 39577 MW; DCEF031E3E9ED7D9 CRC64; MKTFVTEALF LLLQVLLAMT SHPDGTHFFG FFQTLFTLPW MPKPQFISVG FVDDIQFERF NSRRDVQRTE HCAPWKDQKK PEYWKDNTDL VLSYFQDLTE ILQRMLKIYN YSLTGYHTIQ RRYGCYILPR GYFRNGFFEV VFNDHDSIRL NEDLSTWTPV GKFAEILREE WDSSGFTQNV KNFLEVECVD LFLTELEYGK EILLRTDIPK IHVIRKVRPD KKITLRCWAL KFYPAEITLT WERDKSNQTL DMEVTETMPT GDGTFQKWAA VVVLSGEEHR YKCHVNHEGL PEPITLRWVP PEPTISFMHI VIVVVLGALL MGAMMTLLIW KRRTR // ID F6UD96_MONDO Unreviewed; 352 AA. AC F6UD96; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 12-SEP-2018, entry version 50. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000017073}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000017073, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000017073, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000017073} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6UD96; -. DR STRING; 13616.ENSMODP00000017073; -. DR Ensembl; ENSMODT00000017389; ENSMODP00000017073; ENSMODG00000013649. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6UD96; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002280; Chromosome 4. DR Bgee; ENSMODG00000013649; Expressed in 7 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; IBA:GO_Central. DR GO; GO:0019770; F:IgG receptor activity; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 352 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003343913. FT TRANSMEM 296 324 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 352 AA; 38632 MW; D6ED2763B42325F4 CRC64; MGSASPSPQG LPLRLALFLP LLRVLSAGTP SLFYQLTAVA AAPPGTPSFW ASGWLGPQLF LTYSSGGSAE PWGAWRWEHQ EAWFWEKETW YLKTQERLLQ EALRLSKGAQ TFQGLVGCQL NPNNSAYPTS RFALDGMDFL TFDPVARDWL GNSEGAQAVR RHWANETHRA DREAQFLLTT CPEKLRSHLQ NGKGNFQWKG MPPRCELEAT PGQGQSTLTC QAFSFFPPEV KLTFLREGKP VPEPEKGAEP WPNRDGAFHS QATLQVQRGD EARYSCEVRH PALATPLTVS FEASGLSLAV IGGLVAACLL ILLPIAAVVA LVMWKKRGRP APWIFRGRAA DDVGALLSAP GP // ID F6UE14_HORSE Unreviewed; 327 AA. AC F6UE14; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000013567}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013567, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000013567, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013567, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000013567} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013567}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR PRIDE; F6UE14; -. DR Ensembl; ENSECAT00000016778; ENSECAP00000013567; ENSECAG00000015505. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000015505; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; F6UE14; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 327 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003343921. FT TRANSMEM 306 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 88 115 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 327 AA; 36907 MW; 695D2FE08305576A CRC64; MRVKAPRAFL LLLSGALTLI DTWAGSHSMR YFKTVMSSHG RGETHFIVVG YVDDTQFVRF DSDAASPRME PRAPWMEQEG QEYWEEQTRN VKDTAQKLEA ELNTLRNYYN QSKAVSHTYQ WTHGCYVGTD GHLLLGYSQY AYDGIDHLSL NEDLRSWTAM NTAAQITQRK LEAAGATEQH RHYLEGTCVE WLLRHMENGK QTLQRIEPPK THVTHHPISD HEVTLRCWAL GLYPAEITLT WQRDGEDLTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQT YTCHVQHEGL PEPVTLRWEP PPQSTILIVG VIAGLGLLGA VVAGAVI // ID F6UMA6_MONDO Unreviewed; 357 AA. AC F6UMA6; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 12-SEP-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000017918}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000017918, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000017918, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000017918} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6UMA6; -. DR STRING; 13616.ENSMODP00000017918; -. DR Ensembl; ENSMODT00000018248; ENSMODP00000017918; ENSMODG00000014336. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6UMA6; -. DR OMA; QPRFIAV; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002280; Chromosome 2. DR Bgee; ENSMODG00000014336; Expressed in 7 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 301 325 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 357 AA; 40286 MW; 6C93208A90016EB8 CRC64; MESVVLSLLL EAVMLPEIKA SFHSLRYFQT SMSLPGRKPQ FISVGYVDDL QFMLFDGNSP NQREEPRAPW LDQMDQDYWE KNSRISRETA QTFEVGLQNL LVYYNQSEGG LHTYQRLVGC EVSHNRMFRR GFEQYAYDGQ DYISLDFETL SWTAADIPSL NSKHKWEMEP NIAQRQKTYL EKNCVQWLYK YLEIGNETLL RADPPSVRVS RHSGPDGEVS LRCRAQGFYP AEISLTWLRD GEEQLQDTEF IETRPGGDGT FQKWAAVAMA PGQEDRYSCR VQHEALAQPL SLRWEPEAPS VWVIVGVTAG VLVLVTAVVA GAVILRRRNS GGKGGAYVPA ADKDSSQGSD VSLIATG // ID F6V143_HORSE Unreviewed; 361 AA. AC F6V143; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 48. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000013766}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013766, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000013766, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013766, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000013766} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013766}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6V143; -. DR PaxDb; F6V143; -. DR Ensembl; ENSECAT00000016999; ENSECAP00000013766; ENSECAG00000015505. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6V143; -. DR OMA; KTHITHY; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000015505; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; F6V143; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 361 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003344297. FT TRANSMEM 306 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 88 115 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 361 AA; 40588 MW; 3695079F02903EDA CRC64; MRVKAPRAFL LLLSGALTLI DTWAGSHSMR YFKTVMSSHG RGETHFIVVG YVDDTQFVRF DSDAASPRME PRAPWMEQEG QEYWEEQTRN VKDTAQKLEA ELNTLRNYYN QSKAVSHTYQ WTHGCYVGTD GHLLLGYSQY AYDGIDHLSL NEDLRSWTAM NTAAQITQRK LEAAGATEQH RHYLEGTCVE WLLRHMENGK QTLQRIEPPK THVTHHPISD HEVTLRCWAL GLYPAEITLT WQRDGEDLTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQT YTCHVQHEGL PEPVTLRWEP PPQSTILIVG VIAGLGLLGA VVAGAVIWRK KHSDRKGGSY AQAASSDSVK SSEWSLTAGE T // ID F6V4Y4_MONDO Unreviewed; 352 AA. AC F6V4Y4; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 12-SEP-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000017908}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000017908, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000017908, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000017908} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6V4Y4; -. DR STRING; 13616.ENSMODP00000017908; -. DR Ensembl; ENSMODT00000018238; ENSMODP00000017908; ENSMODG00000014450. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6V4Y4; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002280; Chromosome 2. DR Bgee; ENSMODG00000014450; Expressed in 7 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 352 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003344387. FT TRANSMEM 296 320 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 352 AA; 39535 MW; F316B3A446FD86D4 CRC64; MKPSLLSLFV LGVVALTETR AGSHSMRYFY TSMSRPELGD SQFISVGYVD DQQFVRFDSS SESQRAEPRA AWMDQMDEED RNYWEGQTQI NRRTAQITRV DLETALGYYN QSRGGLHTIQ RMYGCEVHPD GSFRKGFYQL AYDGRDYIAL HRETLTWTAA DPGAENTKRK WEAERSFAER VKAYLEETCV QWVKKYLQMG EDVLLRTDPP SARVSLRCRA QGFYPAEISL TWLRDGEEQL QDTEFIETRP GGDGTFQKWA AVAMAPGQED RYSCRVQHEA LAQPLSLRWE PEAPSVWVIV GVTAGVLVLV TAVVAGAVIL RRRNSGGKGG AYVPAADKDS AQGSDVSLTV TA // ID F6V720_ORNAN Unreviewed; 157 AA. AC F6V720; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000023672}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000023672, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [2] {ECO:0000313|Ensembl:ENSOANP00000023672} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000023672}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6V720; -. DR Ensembl; ENSOANT00000023676; ENSOANP00000023672; ENSOANG00000015040. DR GeneTree; ENSGT00900000141162; -. DR OMA; RETRICK; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF342059; -. DR Proteomes; UP000002279; Unplaced. DR Bgee; ENSOANG00000015040; Expressed in 6 organ(s), highest expression level in heart. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}. FT DOMAIN 14 100 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 157 AA; 17903 MW; A592234C56E33623 CRC64; GLLTLWTEAT CSRLYYFTTG VTRPGPGASE FTSEGYVDHV QFVRFAGDGG RGRAEPRTPW IRDNGGREYW DQETEIFRCG AQNFRVGLQN IMSYYNQSKY GYDGRDYIAL DKAKLSWTAA DAGALNTKRK WEADGTIAER YKGYLEGECI ECLQRYL // ID F6V7P5_XENTR Unreviewed; 301 AA. AC F6V7P5; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000053837}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000053837, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000053837} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000053837}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000053837} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099289; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F6V7P5; -. DR STRING; 8364.ENSXETP00000053837; -. DR PaxDb; F6V7P5; -. DR Ensembl; ENSXETT00000053837; ENSXETP00000053837; ENSXETG00000009077. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6V7P5; -. DR OMA; RREPWYL; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000009077; Expressed in 9 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 276 298 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 179 266 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 301 AA; 34503 MW; 25E29EDF1BE50677 CRC64; HTLHYDVTIV SAPTPGVPRY LVSMYVDGVQ YGRYNSDTCH AEALYPSLGA LSEHIEKQTQ YAQGYEMRQR RRLKSLNGYL NKTRGNGNIY QRRLACELYE DGTIGGYEEI AFDGQELLVY DKERVVYVPV TQEAEMLSFI WNIRCGPTDT KIYMENDCIE HIKLYLPYIS TDLERKVPPN VNISSSESES GTKLHCRVYG FYPRDVEVKW IKNGRDEIHS EEAAQILPNP DGTYQIRVSV GVTPDKNSNY SCLVDHNSLE TPIIVTFVPN NGRSHLYFII PVSVIFLLLL IILGIFIYRK Q // ID F6V7Q7_XENTR Unreviewed; 338 AA. AC F6V7Q7; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000053836}; DE Flags: Fragment; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000053836, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000053836} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000053836} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099283; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099284; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099285; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F6V7Q7; -. DR STRING; 8364.ENSXETP00000053836; -. DR PaxDb; F6V7Q7; -. DR Ensembl; ENSXETT00000053836; ENSXETP00000053836; ENSXETG00000033941. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6V7Q7; -. DR OMA; MKNATQT; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000033941; Expressed in 11 organ(s), highest expression level in heart. DR ExpressionAtlas; F6V7Q7; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 302 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSXETP00000053836}. SQ SEQUENCE 338 AA; 38648 MW; 437DA9A94ED77CB6 CRC64; QNKYLPLFYS SYTPVSVSIG SHTLHYDVTI VSAPTPGVPR YLVSMYVDGV QYGKYNSDIR HAEALYPSLR ALSEHIERQT QYAQEHEMRQ RHRLNFLKGY LNTKESNGNI YQRRLACELY EDGTIGGYEE IAFDGKEFFS FDKERVVYVP VTQEAAMLSY LWNIRYDPTD TKIYMENDCI EHIKLYLPYI STDLEKKIPP KVKVSSSESE SGTKLHCRVY GFYPRDVEVK WIKNGRDEIH SEEAAQILPN PDGTYQIRVS VGVTLDKNSN YSCLVDHSSL ETPMIVNFGD ACNKESEMPP SLLVVLSCPV IGQVASVSLH VILGIFIYRK RMTYVTGV // ID F6VIK5_CALJA Unreviewed; 498 AA. AC F6VIK5; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000037256}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000037256, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000037256, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000037256} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9483.ENSCJAP00000037256; -. DR Ensembl; ENSCJAT00000039352; ENSCJAP00000037256; ENSCJAG00000043365. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6VIK5; -. DR OMA; SALTKTW; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 498 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015318212. FT TRANSMEM 440 465 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 343 431 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 498 AA; 55994 MW; E773DC86153A5129 CRC64; MKSEGRGTGP MLRVSLWFLS SSWAKTQGDI DTERLAQEER GQGEVPGPRY GSQGLRTRRR CMDWEAQRWG FPISAVSLPL PTCVRSFFLD THDANPVLTP IGCRVSREAN QLPAVPVLKS PVTHPDSDYP QMLRMTVMAP RTLLLLLSGT LALTQTRAGS HSLRYFHISV SRPGRGEPRF ITVGYVDDTQ FVRFDSDAAS PRKEPRAPWM EQEGPEYWDR ETLISKQNAQ TYRVNLRTLR GYYNQTEAGS HTIQRMYGCD VGPDGRLLRG YNQDAYDGKD YIALNEDLRS WTAADVAAQI TQRKWEAANE AERMRAYLEG TCVEWLRRYL ENGKETLQRA EPPKTHVTHH PVSDHEATLR CWALGFYPAE ITLTWQRDGE DQTQDMELIE TRPAGDRTFQ KWAAVVVLSG EEHRYTCHVQ HEGLPEPLTL RWEPSSQPTI PIMGIVAALA ILGALAGAVV AAVMWRKKSS DKKGGSYSQA ARSESAQGSD VSLTACKV // ID F6VTM7_XENTR Unreviewed; 262 AA. AC F6VTM7; F6QSI4; F6T559; F6T5R7; F6T605; F6T6M9; F6UPP0; F6V7D2; AC F7AXX1; F7EA06; F7EA16; F7EA19; F7EAC2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 12-SEP-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000053844}; GN Name=ncib {ECO:0000313|Ensembl:ENSXETP00000053844}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000053844, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000053844} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000053844}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000053844} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099323; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F6VTM7; -. DR STRING; 8364.ENSXETP00000053844; -. DR PaxDb; F6VTM7; -. DR Ensembl; ENSXETT00000053844; ENSXETP00000053844; ENSXETG00000030785. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; YLEGICI; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000030785; Expressed in 9 organ(s), highest expression level in brain. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}. FT DOMAIN 174 259 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 262 AA; 29721 MW; 8F2DBB0AF168C83B CRC64; MVSVAAPGLP QYSITAFVDD VMIGRYSSDT RDIETFVPVP EILSWHVRRK MEYAFHLEEE EKKGLEKVMV FSNMTYGDAD IHVYQKKFIC ELDDDGSVGG YQEAAFDGES FATFDKEKGV FVPLTQKASD VIQQCANCDL YAKSDKFYME NYCIHDLKLY LPYLIKMLDK KVCPKVKISS LESDNNTKLH CCVYGFHPRE VDVKWIKNGR DEIHSEEAPQ ILPNPDGTYQ IRVSVGVTPE GGATYSCHID HSSLNDTLVV PF // ID F6W0F1_ORNAN Unreviewed; 365 AA. AC F6W0F1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000023863}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000023863, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [2] {ECO:0000313|Ensembl:ENSOANP00000023863} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000023863}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6W0F1; -. DR Ensembl; ENSOANT00000023867; ENSOANP00000023863; ENSOANG00000015154. DR eggNOG; ENOG410IZF6; Eukaryota. DR eggNOG; ENOG41119ST; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6W0F1; -. DR OMA; ECKLEAN; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Proteomes; UP000002279; Unplaced. DR Bgee; ENSOANG00000015154; Expressed in 3 organ(s), highest expression level in female gonad. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 218 237 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 319 339 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 204 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 41438 MW; 1B8B9114212048B1 CRC64; GVELSCLIHL TMHLPRTEHH IGTFFLTAVS GYDGFFELTA IILLDGQQMA SYNSTVREVV FSLNWLYQVV GGQLVQEKKA ELERYEKDFR WGMENWARYL NHSSRTQTVQ LIMGCELDRG VQVVSRFRFA YEGQDVLWLD ELKGTWVTAG PAKKQFRHFW EERVFWSRVA EHYVREECPF LMRMVLHFWY LREHTFSLSP SVPPEVTVTR HDAKDGRVIF ICLATGFYPS SILLRWVKDG EVGLWGDESS SGTLPNADFS FYVRQTLEVQ GEVGDSGYAC VVEHSALDGP IFFPGAGRTD ILPPAAPEKS SWLMPWDQAL GVMAAAALVL SPAVGIIIWK KKKTAGFIPR PLPPTPDGNT WKGEE // ID F6W143_HORSE Unreviewed; 245 AA. AC F6W143; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000013968}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013968, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000013968, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013968, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000013968} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013968}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6W143; -. DR PaxDb; F6W143; -. DR PRIDE; F6W143; -. DR Ensembl; ENSECAT00000017219; ENSECAP00000013968; ENSECAG00000016428. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6W143; -. DR OMA; NIAFLEP; -. DR OrthoDB; EOG0907079Q; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000016428; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 191 214 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 94 182 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 245 AA; 27530 MW; 7BEF32497071592C CRC64; SHTYQWTHGC YVGTDGHLLL GYSQYAYDGI DHLSLNEDLR SWTAMNTAAQ ITQRKLEAAG ATEQHRHYLE GTCVEWLLRH MENGKQTLQR IEPPKTHVTR HSISDHEVTL RCWALGFYPA EITLTWQRDG EDLTQDTELV ETRPAGDGNF QKWAAVVVPS GEEQRYTCHV QHEGLPEPVP LRWEPPPQST ILIMDVIAVL GLLGAVVGGA VICWKKCSGR EGMRSEFSYS DSSQDTVVSL MDPKG // ID F6W2J0_CALJA Unreviewed; 366 AA. AC F6W2J0; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000037249}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000037249, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000037249, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000037249} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSCJAT00000039345; ENSCJAP00000037249; ENSCJAG00000040131. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015315240. FT TRANSMEM 304 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 159 179 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 366 AA; 40536 MW; 40C0271C82049AFB CRC64; MAPRILLLLS GALALTKTSA SSHSFSRFLT TVSRPGRGEP RHIAVGYVDD TQFMRFDSDA AIPRMEPRAP WAEQEGPEYW DLLTRRTEAC AQACRVSLQI IRGHYNQSEA GSHTLQVLFG CDLGPDGRLL RGYCRIAYDG KDHVALNEDL RSWTAADTAA QVTQRKLEAE KYAERLRAQL EGECVGMLKR FLENGKETLE RAEPPKTRVT HHPINDHEAT LRCWALGFYP AEITLTWQRD GEDQTQDTEL VETRPAGDGT FQKWAAMVVP SGEEQRYTCH VQHEGLPEPL TLRWEPPSQP TIPIVSIVAG LVVLAAVVTG AVVSAAMWKR KSSGRERVRG SDSARGSDVS LTVCKGETLG VSSGRE // ID F6W2R7_CALJA Unreviewed; 371 AA. AC F6W2R7; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000051537}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000051537, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000051537, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000051537} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9483.ENSCJAP00000051537; -. DR Ensembl; ENSCJAT00000056675; ENSCJAP00000051537; ENSCJAG00000040131. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6W2R7; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 371 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015344205. FT TRANSMEM 304 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 159 179 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 371 AA; 40893 MW; 8DA23E636C53D8B1 CRC64; MAPRILLLLS GALALTKTSA SSHSFSRFLT TVSRPGRGEP RHIAVGYVDD TQFMRFDSDA AIPRMEPRAP WAEQEGPEYW DLLTRRTEAC AQACRVSLQI IRGHYNQSEA GSHTLQVLFG CDLGPDGRLL RGYCRIAYDG KDHVALNEDL RSWTAADTAA QVTQRKLEAE KYAERLRAQL EGECVGMLKR FLENGKETLE RAEPPKTRVT HHPINDHEAT LRCWALGFYP AEITLTWQRD GEDQTQDTEL VETRPAGDGT FQKWAAMVVP SGEEQRYTCH VQHEGLPEPL TLRWEPPSQP TIPIVSIVAG LVVLAAVVTG AVVSAAMWKR KSSGGKQGSY SQATCSDSAR GSDVSLTVCK GETLGVSSGR E // ID F6W417_ORNAN Unreviewed; 249 AA. AC F6W417; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000011481}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000011481, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [2] {ECO:0000313|Ensembl:ENSOANP00000011481} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000011481}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6W417; -. DR Ensembl; ENSOANT00000011483; ENSOANP00000011481; ENSOANG00000007216. DR eggNOG; ENOG410IZF6; Eukaryota. DR eggNOG; ENOG41119ST; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6W417; -. DR OrthoDB; EOG091G0HHE; -. DR TreeFam; TF352056; -. DR Proteomes; UP000002279; Unplaced. DR Bgee; ENSOANG00000007216; Expressed in 6 organ(s), highest expression level in heart. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 202 225 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 101 182 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 249 AA; 27783 MW; D1752BBDC2339006 CRC64; MRFQNRSGGT HTLQLIVGCE LDQDIQVGRV FRFAYDGEDF YWLDEQRGVW ISSGLAADRY LPFWEGSPFW SEVVRRYTKE ECASLMKITL QYWNLIESTP PEVTVTRHDG PDGSLTLSCL ATGFYPSSIL LRWVKDGEEG LWGEESSSGT LPNADDTFYL RQTLQLRAEA GNPSYACLVE HSILGVPTAF PAPLKPKWKM PWSLALGMVA AGVLVLSPAV GFILWRKKKT DPERLGHCCS GGDGGPESR // ID F6WCX4_HORSE Unreviewed; 362 AA. AC F6WCX4; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000018273}; GN Name=EQMHCC1 {ECO:0000313|Ensembl:ENSECAP00000018273}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000018273, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000018273, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018273, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000018273} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018273}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6WCX4; -. DR STRING; 9796.ENSECAP00000018273; -. DR PaxDb; F6WCX4; -. DR Ensembl; ENSECAT00000022135; ENSECAP00000018273; ENSECAG00000019928. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6WCX4; -. DR OMA; HYLEEEC; -. DR OrthoDB; EOG091G1MMC; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000019928; Expressed in 3 organ(s), highest expression level in liver. DR ExpressionAtlas; F6WCX4; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003349561. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40363 MW; A9DA6F83A1688C63 CRC64; MRVIAPRTLM VLLSGALALT KTWAGSHSMR YFSTAVSRPG RGESWYLEVG YVDDTQFVRF DSDAASPRME PRAPWMEQEG PEYWEEETQR AAGLAHSFRG NLNNLRGYYN QSEAGSHTLQ LMYGCDVGPH GRLLSASFQY AYDGADYLAL NEDLRSWTAA DTAAQISKRK KEVAGNAKYW RNYLEGTCVK WLSRYLENGK ETLQRADPPK THVTHHPISD SEVTLRCWAL AFYPAEITLT WQHIGEDLTQ DMELVETRPS GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPIILRWEP SHESIIHILG IVAGLVLLLV TGAVVAVIWR KKHSDGKGGS YAQAASCNSA QGSDVCLIAA ET // ID F6WEG0_XENTR Unreviewed; 308 AA. AC F6WEG0; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 46. DE SubName: Full=Major histocompatibility complex class I antigen precursor {ECO:0000313|Ensembl:ENSXETP00000033387}; GN Name=LOC100127707 {ECO:0000313|Ensembl:ENSXETP00000033387}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000033387, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000033387} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000033387}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000033387} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01149900; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 8364.ENSXETP00000033387; -. DR PaxDb; F6WEG0; -. DR Ensembl; ENSXETT00000033387; ENSXETP00000033387; ENSXETG00000015263. DR Xenbase; XB-GENE-5873924; loc100127707. DR eggNOG; ENOG410ITUC; Eukaryota. DR eggNOG; ENOG4111EG6; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6WEG0; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G0BU8; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000015263; Expressed in 18 organ(s), highest expression level in ciliary marginal zone. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 281 303 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 185 273 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 308 AA; 35485 MW; 7B09271F42960078 CRC64; PAAHTLHYAF TLVSNSAGQS YFVVAFVDDA QIGRYSSDTQ KVEPLLDWMK ERLEPQHWET MTSWGKHYQN CHTKDMGFFI DRFNNTYGDR GPFIYQVNFA CEVHEDGGVS GHEAFAFNGN EFMFFDKGNM RFVPVRREAE VIAQVWNGQQ FSAIKHKNHM EQDCVQWMAL YLRYGKGRLE KKVQPTVKVF SRESDGATKL YCWVYGFYPR DVDVRWVRNG TEEDSEEHKE ILPNPDGTYQ IRITLTMQPA DVDSYSCHVD HSSVNGTQIY KLPEPDKRGH VIVIACVAVV FIMAVAVVVA AVLKFKRR // ID F6WJ49_MONDO Unreviewed; 308 AA. AC F6WJ49; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000014153}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000014153, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000014153, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000014153} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6WJ49; -. DR Ensembl; ENSMODT00000014415; ENSMODP00000014153; ENSMODG00000011316. DR eggNOG; ENOG410KEP1; Eukaryota. DR eggNOG; ENOG4111939; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6WJ49; -. DR OrthoDB; EOG091G1FPA; -. DR TreeFam; TF352056; -. DR Proteomes; UP000002280; Chromosome 1. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 282 305 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 181 271 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 308 AA; 35003 MW; ECD4EB0058172FE8 CRC64; NSVHHSHIGQ FTAVGTAHSL LELSAINFLN DIEVGSYNKA HKQIIVKIPW ISKALGVNNI IKKINLLVEH EQHFRWTIQF LSRNDTNHNR NHTAQLLAEC EIDNNITVKS HIYLIWDGVE YFRIDEEVGH WENINPEFKE YQHILESPFW TTLRKRYMKL YCVDLMRKIV GYSSIRDNVV PEVAVSQHVS PEGSIILSCI ASGFYPRSIL MSWEKYGKLG IWGNESSSGT LPNMDSTFYL KVTLELPPED SGAGYTCVVE HSELKSPAIY SVPGKSTVEK SWVLELGIVL AIILLLSCAG AIIIWKKR // ID F6X3R7_ORNAN Unreviewed; 220 AA. AC F6X3R7; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 23-MAY-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000029074}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000029074, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [2] {ECO:0000313|Ensembl:ENSOANP00000029074} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000029074}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6X3R7; -. DR Ensembl; ENSOANT00000032869; ENSOANP00000029074; ENSOANG00000022751. DR GeneTree; ENSGT00740000114936; -. DR OMA; QYLTHEC; -. DR OrthoDB; EOG091G0HHE; -. DR Proteomes; UP000002279; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 194 214 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 93 182 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 220 AA; 24773 MW; 1A83346D3E3D0F0B CRC64; THTVQLLMGC ELDRGVQVGT RFRFSCTGED FFWLNELQGS WVADEPLGNH FQLVWEERDF LFRVAKHYIQ EECAVLLRNI LHFWSLTTHE PGPAEVTTIL QEAPDGYLTL SCLATSFYPS SILLRWVKRG CGKRRVPSST LPNANGTFYL HQTLELQAKT GNSDYACLVE HSTLQVPTAY LEWYLCAYNV PGSVLSAAVG IGLVLSPSVG FILWRKKKTG // ID F6XA91_HORSE Unreviewed; 275 AA. AC F6XA91; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000021611}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021611, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000021611, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021611, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000021611} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021611}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSECAT00000025949; ENSECAP00000021611; ENSECAG00000023986. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000023986; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; F6XA91; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 221 242 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 126 214 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 275 AA; 30964 MW; 462E0FD54252C798 CRC64; EEETQKMKGH EQNFRVGLNT LRGYYNQSEA GSHTFQKVSG CHVGPDGRLL RGYKQYAYDG ADYIALNEDL RSWTAADTAA QITQRKWEAA GEAEYDRNYL EGPCVEWLLR YLENGKETLQ RADQTPKSHV THHPISDHEV TLRCWPLGFY PVEITLTWQR DGEDLTQDME FVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLSEP LTLRWEPPPQ LIIPIVGIVS GLVLLGAGAV MWRKKCSGEK RRSSAQATDN DSAQGSDASL MDPKV // ID F6XH52_HORSE Unreviewed; 357 AA. AC F6XH52; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 49. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000014450}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000014450, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000014450, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014450, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000014450} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014450}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6XH52; -. DR PaxDb; F6XH52; -. DR Ensembl; ENSECAT00000017767; ENSECAP00000014450; ENSECAG00000015782. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6XH52; -. DR OMA; GREDQCQ; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000015782; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; F6XH52; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 357 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003345222. FT TRANSMEM 303 325 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 357 AA; 40360 MW; 24E91DE237FF8F5F CRC64; MRVMRPPTFL LLLCGLLSLT ETWAGSHSLR YFYAAVSRDR RQERFISLGE HDTFFRCGFK GTPESPIRQR RGAMKQQYRN YLSKTAESLN EGGEFRGNLN TLRGYYNQSE AGSHTLQRMC GCDLGPDRRL LRGYSQDAYD GADYIALNED LRSWTAADTA AQISRRKWEA AGHAERWRNY LEGRCVEWLL RYLENGKETL QRADPPRTHV THHPISDHEV TLRCWALGFY PAEIALTWQR DGEDLTQDTE LVETRPAGDG TFQKWAAVVV PAGEEQRYTC HVQHEGLPEP LTLRWELPPQ STILIVGVLA GLGLPVVVVA GAVTWRKKRS GEKRGSYVQT ANSDSAQGSD ASLTQKG // ID F6XKY5_CANLF Unreviewed; 381 AA. AC F6XKY5; DT 31-OCT-2012, integrated into UniProtKB/TrEMBL. DT 31-OCT-2012, sequence version 1. DT 12-SEP-2018, entry version 43. DE SubName: Full=MHC class Ib precursor {ECO:0000313|Ensembl:ENSCAFP00000012096}; GN Name=DLA-79 {ECO:0000313|Ensembl:ENSCAFP00000012096}; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000012096, ECO:0000313|Proteomes:UP000002254}; RN [1] {ECO:0000313|Ensembl:ENSCAFP00000012096, ECO:0000313|Proteomes:UP000002254} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000012096, RC ECO:0000313|Proteomes:UP000002254}; RX PubMed=16341006; DOI=10.1038/nature04338; RG Broad Sequencing Platform; RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., RA Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., RA Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F., RA Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., RA Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., RA Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., RA Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., RA Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., RA Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., RA Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., RA Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., RA Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., RA Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., RA Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., RA Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., RA Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., RA Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., RA Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., RA Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., RA Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., RA Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., RA Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., RA Marabella R., Maru K., Matthews C., McDonough S., Mehta T., RA Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., RA Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., RA Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., RA Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., RA Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., RA Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., RA Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., RA Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., RA Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., RA Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., RA Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., RA Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., RA Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.; RT "Genome sequence, comparative analysis and haplotype structure of the RT domestic dog."; RL Nature 438:803-819(2005). RN [2] {ECO:0000313|Ensembl:ENSCAFP00000012096} RP IDENTIFICATION. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000012096}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAEX03011468; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F6XKY5; -. DR STRING; 9615.ENSCAFP00000012096; -. DR PaxDb; F6XKY5; -. DR PRIDE; F6XKY5; -. DR Ensembl; ENSCAFT00000013073; ENSCAFP00000012096; ENSCAFG00000008234. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR OMA; RMANEDW; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Reactome; R-CFA-1236974; ER-Phagosome pathway. DR Reactome; R-CFA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-CFA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-CFA-6798695; Neutrophil degranulation. DR Reactome; R-CFA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002254; Chromosome 18. DR Bgee; ENSCAFG00000008234; Expressed in 3 organ(s), highest expression level in prefrontal cortex. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002254}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002254}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 381 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003346103. FT TRANSMEM 314 337 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 215 301 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 381 AA; 43112 MW; 84554858B2724D00 CRC64; MPVMRPRTLL LLLLLLLLSG TLGLAQTSAG SHSLRFLNTV VSRPGHGEPR HWAVAYVDDT PFERFNSERE GRRPEPLVRW LEQEGPEYWE ERTLNSRTCT QVLRRTLNEV SQDYSNQSRT GSHTFQTITG CDVGPDGRFL RGYQRHAYDG LDYITLSEDL RSWIVEDPVA QITRRKWDAA TVAENRKNFL EGRCLEWLRR HLENGRETLQ RADPPKTSVT RRPISEHEVT LKCWALGFYP AEITLTWQRD GEDQTQDTEL VETRPGGDGT FQKWAAVVVP SGEEQRYTCH ILHKSLPKPI TLRWEPPPQS TIPIVSIIAG LVLLVITGAM LVGVVIWRKK HSGRKGGSYS QAENKYGGSS AQDSQMSVMA PNEQASCLVG L // ID F6XUA3_HORSE Unreviewed; 263 AA. AC F6XUA3; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000021595}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021595, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000021595, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021595, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000021595} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021595}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSECAT00000025930; ENSECAP00000021595; ENSECAG00000023986. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000023986; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; F6XUA3; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 263 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003350878. FT TRANSMEM 209 230 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 114 202 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 263 AA; 29366 MW; 13A280037B184D33 CRC64; MPPTFLLLLS GTLTQTWAGS HTFQKVSGCH VGPDGRLLRG YKQYAYDGAD YIALNEDLRS WTAADTAAQI TQRKWEAAGE AEYDRNYLEG PCVEWLLRYL ENGKETLQRA VLTPKSHVTH HPISDHEVTL RCWPLGFYPV EITLTWQRDG EDLTQDMEFV ETRPAGDGTF QKWAAVVVPS GEEQRYTCHV QHEGLSEPLT LRWEPPPQLI IPIVGIVSGL VLLGAGAVMW RKKCSGEKRR SSAQATDNDS AQGSDASLMD PKV // ID F6XUF3_HORSE Unreviewed; 349 AA. AC F6XUF3; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000021590}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021590, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000021590, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021590, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000021590} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021590}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6XUF3; -. DR STRING; 9796.ENSECAP00000021590; -. DR PaxDb; F6XUF3; -. DR Ensembl; ENSECAT00000025925; ENSECAP00000021590; ENSECAG00000023986. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6XUF3; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000023986; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; F6XUF3; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 349 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003350864. FT TRANSMEM 300 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 349 AA; 39370 MW; 9A64475217DF7B01 CRC64; MRVMMPPTFL LLLSGTLTQT WAGSHSMRYY KTAVSPGRGE PRFVAVGYVD DTQFVRFDSD AASPRMEPRA PWVEQAGPEY WEEETQKMKG HEQNFRVGLN TLRGYYNQSE AGSHTFQKVS GCHVGPDGRL LRGYKQYAYD GADYIALNED LRSWTAADTA AQITQRKWEA AGEAEYDRNY LEGPCVEWLL RYLENGKETL QRAEPPKHVT HHPISDHEVT LRCWPLGFYP VEITLTWQRD GEDLTQDMEF VETRPAGDGT FQKWAAVVVP SGEEQRYTCH VQHEGLSEPL TLRWEPPPQL IIPIVGIVSG LVLLGAGAVM WRKKCSGEKR RSSAQATDND SAQGSDASL // ID F6XUK2_HORSE Unreviewed; 354 AA. AC F6XUK2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 49. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000019275}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000019275, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000019275, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019275, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000019275} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019275}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9796.ENSECAP00000019275; -. DR PaxDb; F6XUK2; -. DR Ensembl; ENSECAT00000023286; ENSECAP00000019275; ENSECAG00000020991. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6XUK2; -. DR OMA; VPGYYNQ; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000020991; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 354 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003345566. FT TRANSMEM 299 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 354 AA; 39732 MW; C0B4623FC8F926BD CRC64; IRVMAPGTLL LLLSGTLTLT ETWAGSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRAE PRAPWMEHVG PEYWERNTRI FKDNAQTFRG SLNNLRGYYN QSEAGSHTLQ VVYGCDVGPD GRLLRGYRQD AYDGADYIAL NEDLRSWTAT RRKWEAAGEA ERWRNYLEGT CVEWLLRHLE NGKETLQRAD PPKTHVTHHA ISDHEVTLRC WALGFYPAEI TLSWQRDGED LTQDTELVET RPSGDRTFQK WAAVVVPSGE EQRYTCRVQH EGLPEPVTLR WEPPPESPIL TVGVIAGLLL LGAVVVGLVI WRKKRSGEKG RGYAQAASSD SAQGSDVSLK AGDT // ID F6XXZ1_HORSE Unreviewed; 239 AA. AC F6XXZ1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000014661}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000014661, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000014661, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014661, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000014661} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014661}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSECAT00000018004; ENSECAP00000014661; ENSECAG00000015782. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000015782; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; F6XXZ1; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 185 207 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 88 176 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 239 AA; 26735 MW; 167E0CA5C5D634D6 CRC64; MCGCDLGPDR RLLRGYSQDA YDGADYIALN EDLRSWTAAD TAAQISRRKW EAAGHAERWR NYLEGRCVEW LLRYLENGKE TLQRADPPRT HVTHHPISDH EVTLRCWALG FYPAEIALTW QRDGEDLTQD TELVETRPAG DGTFQKWAAV VVPAGEEQRY TCHVQHEGLP EPLTLRWELP PQSTILIVGV LAGLGLPVVV VAGAVTWRKK RSGEKRGSYV QTANSDSAQG SDASLTQKV // ID F6XZ61_HORSE Unreviewed; 330 AA. AC F6XZ61; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 44. DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSECAP00000002663}; GN Name=FCGRT {ECO:0000313|VGNC:VGNC:17976}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000002663, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000002663, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002663, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000002663} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002663}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6XZ61; -. DR STRING; 9796.ENSECAP00000002663; -. DR PaxDb; F6XZ61; -. DR Ensembl; ENSECAT00000003823; ENSECAP00000002663; ENSECAG00000002855. DR VGNC; VGNC:17976; FCGRT. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6XZ61; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 10. DR Bgee; ENSECAG00000002855; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; IBA:GO_Central. DR GO; GO:0019864; F:IgG binding; IEA:Ensembl. DR GO; GO:0019770; F:IgG receptor activity; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 275 297 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 177 264 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 330 AA; 36617 MW; 8D947415F9760103 CRC64; AESRPSLLYH FTAVSSPAPG APAFWVSGWL GPQQYLSYNN LRAQAEPCGA WVWENQVSWY WEKETTDLRK KEKLFLDAFQ VLTEEGPHTL QGLLGCELNP DNTSVPVAKF ALDGEDFMEF DLKLGAWNGD WPEALAIGQR WARQADTDEN RSSLLYSCPE RLLREERRRE NLEWKEPPSM RLKARPGSPG FSVLTCSAFS FYPPELQLRF LRNGLAAGSG EGDLGPNGDG SFYAWSSLTV KSGDEYHYRC WVQHAGLAQP LTVELESPAK SPMQVVGIVV GVLLLLVLAA GGALLWWRMR KGLPAPWISL RGDDIGALLP APGLPKDADS // ID F6Y8E3_HORSE Unreviewed; 179 AA. AC F6Y8E3; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000002109}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000002109, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000002109, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002109, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000002109} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002109}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6Y8E3; -. DR STRING; 9796.ENSECAP00000002109; -. DR PaxDb; F6Y8E3; -. DR Ensembl; ENSECAT00000002946; ENSECAP00000002109; ENSECAG00000003090. DR eggNOG; ENOG410JBPA; Eukaryota. DR eggNOG; ENOG411150N; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F6Y8E3; -. DR OMA; WQFAING; -. DR OrthoDB; EOG091G0NI5; -. DR TreeFam; TF339658; -. DR Proteomes; UP000002281; Chromosome 31. DR Bgee; ENSECAG00000003090; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}. FT DOMAIN 11 171 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 179 AA; 20453 MW; C07CB340CC80EB85 CRC64; HSLCLDLTVK PQARPGQPWY EVQGSVDRKP FLQYDSDSKK VRALGLLGEK VNATNAWTDL TRTLGEVGQE LRMVLPVIRL EKNRTRGLPT LQVKLCCQRE AERCTGASWQ FSINGQTAVF DTMSMNWTVI DPGVRGIQEE WENSQDLAEH FRKLSAGDCS HWLREFLEHW EKVLEPTGN // ID F6YFH2_HORSE Unreviewed; 180 AA. AC F6YFH2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000021768}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021768, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000021768, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021768, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000021768} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021768}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9796.ENSECAP00000021768; -. DR PaxDb; F6YFH2; -. DR Ensembl; ENSECAT00000026121; ENSECAP00000021768; ENSECAG00000024295. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F6YFH2; -. DR OMA; EANGHTH; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000002281; Chromosome 31. DR Bgee; ENSECAG00000024295; Expressed in 1 organ(s), highest expression level in prefrontal cortex. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}. FT DOMAIN 1 170 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 180 AA; 21026 MW; 3C650F503638C8E5 CRC64; HSLCYDFTIL PKASPGQSWC EAQGQVDEKT FLSYDCGSQE VKSLSLLGEE VKGTRAWQEQ METLRDVGDF LRQQLLDLKL EKYTDRDPLP LQGRMLCQCE ANGRTRASWQ FGSQGQTFLL FDSENRTWTV LHPRGRRMKE KWESDRDVTE FFRKISLGDC RSWLESFLVH WEKMLETTGT // ID F6YKD3_XENTR Unreviewed; 359 AA. AC F6YKD3; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 49. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000038903}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000038903, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000038903} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000038903} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01044902; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F6YKD3; -. DR STRING; 8364.ENSXETP00000038903; -. DR PaxDb; F6YKD3; -. DR Ensembl; ENSXETT00000038903; ENSXETP00000038903; ENSXETG00000017938. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6YKD3; -. DR OMA; RITQRFY; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000017938; Expressed in 10 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 41607 MW; 39B0705FF2543CBA CRC64; MYMQIISVLA CASCKYKYAH IIVAGSHSYS YFYTGNSDGG QGHPHFTAAA YLDDFPIGVY TSETKTFQIK TKWIEEKADP ALWKNYTNIF QRWETDFRQG VKKMMEHFNQ TEGFHSLQWM YGCELDDDGG IRAYDLDGYD GKEFMALDLD RVIHISSRPE TEAIAHKWNT ETIEAEKMKT YLEVQCIETL KKYISYGKEH LERKVTPQVK VFHQQSAGFI KLHCQVYGFF PQAIKVKWLR SEEEKVQPFE VLQILPNTDF TYQTRVTITV APEEMDTYFC HVEHSSLEKP HIVVWVIPEP SRNNLLYMSL GASSVLLLIL TFVMGLWLGR RRPGKKQKMF CSVVISKDRH SPSTTPISQ // ID F6YLT0_HORSE Unreviewed; 361 AA. AC F6YLT0; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 49. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000002356}; GN Name=LOC100051586 {ECO:0000313|Ensembl:ENSECAP00000002356}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000002356, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000002356, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002356, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000002356} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002356}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6YLT0; -. DR STRING; 9796.ENSECAP00000002356; -. DR PaxDb; F6YLT0; -. DR Ensembl; ENSECAT00000003319; ENSECAP00000002356; ENSECAG00000000325. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6YLT0; -. DR OMA; QPRFIAV; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000000325; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 361 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003346896. FT TRANSMEM 306 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 361 AA; 40566 MW; B3913AE7687773A9 CRC64; MLVMMPPTFL LLLSGSLTLT ETWAGSHSMR YFYTAVSRPG RGEPRYLEVG YVDDTQFERF DSDAASPRAE PRAPWMEQLG PEYWEMSTRN ANGSAQTFRG NLNTLRGYYN QSEAGSHTIQ EMYGCDVGPD GRLLRGYSQF AYDGADYIAL NEDLRSWTAA DAAAQITRRK WETAGEAEDW RNFLEGRCVK WLLRHLENGK ETLQRADPPK THVTHHPISD REVTLRCWAL GFYPAEITLT WQRDGEDLTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPVTRKWEP RPQSPILIVG VIAGLGLLVA VVAGAVIWRK KHSGREGRSY AQAANNDSAQ GSDVSLMDPK V // ID F6YPW4_MONDO Unreviewed; 364 AA. AC F6YPW4; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000018272}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000018272, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000018272, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000018272} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSMODT00000018605; ENSMODP00000018272; ENSMODG00000014624. DR GeneTree; ENSGT00760000118960; -. DR OMA; VTHHPVF; -. DR Proteomes; UP000002280; Chromosome 2. DR Bgee; ENSMODG00000014624; Expressed in 5 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; F6YPW4; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003346987. FT TRANSMEM 307 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 40981 MW; 8892BA4E500BC684 CRC64; FSTMGFFVLS LLLLGILVLT EIRAGSHSLK YFYTAASQPG LAEPRFTAVV YVDDQQVLSF DSDSPSQRIE TRTPWIEQEM SNYWELKTRE ATLRYRMCLQ KVPVYYNHSE GGVHTYQRQA GCEVFSNGSF SRGFAQYGFD GRDYLTLDTG TLRWVAADAG ALNNKRKWEA DQRIAENWKI YLEGECVHSL QRYLENGKER LLRADPPSAR VTRHTSSDGE VTLKCRAQDF YPAEISLVWL REGEEQLQDT EFIETRPAGD GTFQKWAAVE MLSGSEHKYT CRVQHEGLPE PLFLKWGKDG ESQFSSIGLS AGVITILLLL AAVIIGVVVW RKNTSGREEG SYTATASNDS AQGSDVSFTA RSKI // ID F6YQF2_MONDO Unreviewed; 369 AA. AC F6YQF2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000018269}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000018269, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000018269, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000018269} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6YQF2; -. DR STRING; 13616.ENSMODP00000018269; -. DR Ensembl; ENSMODT00000018602; ENSMODP00000018269; ENSMODG00000014624. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6YQF2; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002280; Chromosome 2. DR Bgee; ENSMODG00000014624; Expressed in 5 organ(s), highest expression level in adult mammalian kidney. DR ExpressionAtlas; F6YQF2; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 369 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003346997. FT TRANSMEM 312 335 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 212 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 369 AA; 41747 MW; 37FF3EE7941D7E59 CRC64; FLTMEFFVLS LLLLGTLILT ETWAGKCFHS LKYFYTTMSL PELIEPRFTA VVYVDDQQIL SFDSDSASQS MEPRTQWIKV EPPDYWERVT RISREDSQCN RMCLQKVSTN YNHSEGGVHT YQRQAGCEVF SNGSFSRGFA QYGFDGRDYL TLDTGTLRWV AADAGALNNK RKWEADQRIA ENWKIYLEGE CVHSLQRYLE NGKERLLRAD PPSARVTRHT SSDGEVTLKC RAQDFYPAEI SLVWLREGEE QLQDTEFIET RPAGDGTFQK WAAVEMLSGS EHKYTCRVQH EGLPEPLFLK WGKDGESQFS SIGLSAGVIT ILLLLAAVII GVVVWRKNTS GREEGSYTAT ASNDSAQGSD VSFTARSKI // ID F6YRI2_CALJA Unreviewed; 337 AA. AC F6YRI2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 43. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSCJAP00000007996}; GN Name=MR1 {ECO:0000313|Ensembl:ENSCJAP00000007996}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000007996, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000007996, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000007996} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR RefSeq; XP_008983141.1; XM_008984893.2. DR Ensembl; ENSCJAT00000008452; ENSCJAP00000007996; ENSCJAG00000004391. DR GeneID; 100398548; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 337 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015322123. FT TRANSMEM 296 319 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 158 178 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 337 AA; 39058 MW; D752EEC0E6C77C37 CRC64; MVFLLPLIVV LMAKQSDART HSLRYFRLGV SDPGHGVPEF ISVGYVDSQP ITAYNSITRQ KEPRAPWMAE NLAPDHWERY TQLLRGWQQM FKVELNRLQR HYNHSGSHTY QRMIGCELME DGSTTGFLQY AYDGQDFMIF NKDTLSWLAV DNVAHTIKRA WEANRHELQY QKNWLEEECI AWLKRFLEYG KDTLQRTEPP LVRVNRKETF PGVTTLFCKA HGFYPPEIYM TWMKNGEEIV QEMDYGDILP SGDGTYQRWA SVELDPQSSD LYSCHVEHCG VHMVLQVPQE SETIPLVIKA VSGSIVLVIV LAGIGVLVWR RRPREQNGAI YFPTPDR // ID F6YWS9_MACMU Unreviewed; 298 AA. AC F6YWS9; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 50. DE SubName: Full=Alpha-2-glycoprotein 1, zinc-binding {ECO:0000313|Ensembl:ENSMMUP00000029608}; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSMMUP00000029608}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000029608, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000029608, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000029608, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000029608} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000029608}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03029110; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001181043.1; NM_001194114.1. DR UniGene; Mmu.2996; -. DR STRING; 9544.ENSMMUP00000029608; -. DR Ensembl; ENSMMUT00000031648; ENSMMUP00000029608; ENSMMUG00000022504. DR GeneID; 710136; -. DR KEGG; mcc:710136; -. DR CTD; 563; -. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6YWS9; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Chromosome 3. DR Bgee; ENSMMUG00000022504; Expressed in 12 organ(s), highest expression level in liver. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 298 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003346358. FT DOMAIN 207 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 298 AA; 34429 MW; 28224890A0D63D76 CRC64; MIRMVPVLLS LLLFLGPAVP QETQDGRYSL TYIYTGLSKL VEDIPQFQAL GSLNDLQFFR YNSKDRKSQP VGLWRQVEGM EDWKQDSQLQ KAREDIFMET LNDIVEYYND SNGSHNLHGR FGCEIENNRS SGSFWKYYYD GKDYIEFNKE IPAWVALDPA AQNTKQKWEA EPVYVQRAKA YLEEECPETL RKYLKYSKNI LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT RDGKVQEPEL RGEVLHNENG TYQSWVVVAV PPQDTAPYSC YVQHSSLAQP LVVPGEAR // ID F6Z082_XENTR Unreviewed; 334 AA. AC F6Z082; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000058421}; GN Name=mr1-like {ECO:0000313|Ensembl:ENSXETP00000058421}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000058421, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000058421} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000058421}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000058421} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099306; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099307; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099308; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099309; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSXETT00000065647; ENSXETP00000058421; ENSXETG00000034352. DR eggNOG; ENOG410ITUC; Eukaryota. DR eggNOG; ENOG4111EG6; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000034352; Expressed in 12 organ(s), highest expression level in skeletal muscle tissue. DR ExpressionAtlas; F6Z082; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 292 314 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 195 280 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 334 AA; 38043 MW; AE502F415CD3C9F8 CRC64; YSCYIVNVFL FLFFLGSHTL QFYVAVSSTA YPGLLQYSII AYVDDVRYGR YNSDTRRCES LIQSPMVFSE HLDGQTNMAQ QTEITQKVLM NLIIDLLNKT HDINYVIQTK AACVLHEDGT VDVYEEVALD GKELVVFDKE RVEFVPATQK AVLLAQWLNK QAFAMEDKIF MENECTQHLT LYLPYIKSYL DEKVPRVKLS SSESESGTEL HCRVYGFYPR DVEVKWIKNG RDEIHSEEAA QILPNPDGTY QIRVSVGVTP EEGATYSCHI DHSSLENPLI VPFETEIKNS HITYILIAVG VIVLFLAFGL GFFIQRKMKG LKGSRQSVSS EEQD // ID F6Z8L6_CALJA Unreviewed; 302 AA. AC F6Z8L6; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 12-SEP-2018, entry version 48. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSCJAP00000007976}; GN Name=MR1 {ECO:0000313|Ensembl:ENSCJAP00000007976}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000007976, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000007976, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000007976} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6Z8L6; -. DR STRING; 9483.ENSCJAP00000007976; -. DR Ensembl; ENSCJAT00000008430; ENSCJAP00000007976; ENSCJAG00000004391. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F6Z8L6; -. DR OMA; GYVDSHP; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008225; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 302 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015319197. FT DOMAIN 199 278 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 158 178 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 302 AA; 35278 MW; 666E98641E09FE18 CRC64; MVFLLPLIVV LMAKQSDART HSLRYFRLGV SDPGHGVPEF ISVGYVDSQP ITAYNSITRQ KEPRAPWMAE NLAPDHWERY TQLLRGWQQM FKVELNRLQR HYNHSGSHTY QRMIGCELME DGSTTGFLQY AYDGQDFMIF NKDTLSWLAV DNVAHTIKRA WEANRHELQY QKNWLEEECI AWLKRFLEYG KDTLQRTEPP LVRVNRKETF PGVTTLFCKA HGFYPPEIYM TWMKNGEEIV QEMDYGDILP SGDGTYQRWA SVELDPQSSD LYSCHVEHCG VHMVLQVPQE QNGAIYFPTP DR // ID F6ZGG1_MACMU Unreviewed; 238 AA. AC F6ZGG1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000005271}; GN Name=LOC694076 {ECO:0000313|Ensembl:ENSMMUP00000005271}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000005271, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000005271, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000005271, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000005271} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000005271}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03031932; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9544.ENSMMUP00000005271; -. DR Ensembl; ENSMMUT00000005598; ENSMMUP00000005271; ENSMMUG00000003951. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F6ZGG1; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000003951; Expressed in 11 organ(s), highest expression level in liver. DR ExpressionAtlas; F6ZGG1; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 212 235 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 19 190 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 238 AA; 26725 MW; 7AF6471D16C7B99B CRC64; ALDFQIFYLL LCGPSLYPHS LCYDITIIPK FRPGPRWCAV QGQVDKKTFL PYDCGNKTVT PVSPLGKKLN VTKAWKAQNP VLREVVDMLT EQLLDIELEN YTPREPLTLQ TRMSCEQKAE GHSSGSWQFG FDGQVFLLFD SENRMWATVH PGARKMKEKW QNDKDVTMSF RYISMGDCTK WLKDFLTGTD STLEPSAGAP PTVSSGTTQP SAMATTLILC CLLIILLLIF PCFILPGC // ID F6ZP19_ORNAN Unreviewed; 342 AA. AC F6ZP19; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000005033}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000005033, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [2] {ECO:0000313|Ensembl:ENSOANP00000005033} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000005033}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9258.ENSOANP00000005033; -. DR Ensembl; ENSOANT00000005034; ENSOANP00000005033; ENSOANG00000003172. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6ZP19; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002279; Unplaced. DR Bgee; ENSOANG00000003172; Expressed in 7 organ(s), highest expression level in female gonad. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 342 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003347004. FT TRANSMEM 314 335 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 303 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 342 AA; 38296 MW; E9950315338A36E9 CRC64; STKQARCAPF LPLLLCLGAA LLPAGRTRSH SLRYFTTGVS RPGPGVSEFT SVGYVDDVQF VRFDGDGRRG RAEPRTPWIR DNEGREYWDQ ETKIFRSGAQ NFHVGLQNIM GYYNQSEERS HTVQGLYGCQ LREDNTPGEG FMQFGYDGRD YIALDKATLS WMVADAGALN TKSKWEADGT IAERDKAYLE DECIEWLRRY MGFGGPCLTR ADPPKVDVIR HPGPDGEDVS LRCRAFGFYP ADIKFMWRRE GEDVSLQMEL VDTRPSGDGN FQKWASVSVP RGEELKYVCI VEHEGLAQPL AVKWVPDTSL SNKATVGVVI VILLILVAVV GFVIWKRSGP RG // ID F6ZR75_HORSE Unreviewed; 357 AA. AC F6ZR75; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000011976}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000011976, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000011976, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011976, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000011976} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011976}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR PaxDb; F6ZR75; -. DR Ensembl; ENSECAT00000014949; ENSECAP00000011976; ENSECAG00000013783. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F6ZR75; -. DR OMA; LENECIE; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000013783; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 357 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003352465. FT TRANSMEM 304 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 357 AA; 40151 MW; 533204EB99EAA798 CRC64; MRVRIPRSFL LLLSGALALT ETWAGYHSRR YFYTAVSRPG RGEPRFIAVG CVDDTQFVRF DSDAARPRME PRAPWMAQAG RGYWEEQTRM HKKPETFREK LNTLRGHYNQ SEAGSHTFQR LNGCYVVLDG RLLQGFNLDA YDGADYIVLN EDLRSWTAAD TAAQITQQEC EAVGAAEGFR NYLHGECVEW LRRYLEIGKE TLQRADPPKS HVTRHPISDH EVTLRCWALG FYPAEITLTW QHDGEDLTQD KELVETRPSG DGTFQKWAAV VVPCGEEQSY MCHVQHEGLP EPLTLRWEPP PQSIIPILGI IAGLVLLGAA VAGAVMWRKK RSGREGMSYA QAASSDSAQG SDVSHTA // ID F7A0J0_CALJA Unreviewed; 254 AA. AC F7A0J0; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000049171}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000049171, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000049171, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000049171} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7A0J0; -. DR STRING; 9483.ENSCJAP00000049171; -. DR Ensembl; ENSCJAT00000055456; ENSCJAP00000049171; ENSCJAG00000013455. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F7A0J0; -. DR OMA; QIAKRPL; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000008225; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 254 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015363651. FT DOMAIN 33 201 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 254 AA; 28935 MW; AADBC8FF298AB6AD CRC64; MAAAASSALR QCLPLLLLFQ LSGSSWAETA DPHSLCYDVT ITPKFRPGPR WCAVQGQLDQ KTFLHYDCGN KTVTPVSLLG KKINVTKSWK EQNPVLRELV DMLTEQLLGI QLQNYTPREP LTLQARMSCE QKAEGHSSGS WQFSFDGQIF LLFDSENRMW TTVHPGARKM KEKWENDKDM TMSFHYFSMG DCTRWLEDFL MGMDRTLENG DLKKLVLEFS FNDPSVHIYV KMTPSWGLLL EAPVLSHPPL PSLS // ID F7A7F4_HORSE Unreviewed; 361 AA. AC F7A7F4; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 48. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000019780}; GN Name=MHCB3 {ECO:0000313|Ensembl:ENSECAP00000019780}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000019780, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000019780, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019780, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000019780} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019780}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9796.ENSECAP00000019780; -. DR PaxDb; F7A7F4; -. DR Ensembl; ENSECAT00000023847; ENSECAP00000019780; ENSECAG00000021785. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7A7F4; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000021785; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 361 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003347456. FT TRANSMEM 305 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 361 AA; 40314 MW; 73F0FFC7DF8498D8 CRC64; MKVTAPGTLL LLLSGSLALT ETWAGSHSMR FFYTVVSRPG RGEPRFISVG YVDDTQVSRF DSDAASPRME PRAPWMEQEG PEYWEEQTRW AKDSAQNCRV SLNDLRGDWN HSEAGSHTLQ LRFGCDVGPD GRLLRGYRQS AYDGADYIAL NEDLRSWTAA DTAAQITRRK WEAAGVAERW RNYLEGTCVE WLLRHLENGK ETLQRADPPK THVTRHPISD REVTLRCWAL GFYPEEITLS WERDGEDLTQ DTELVETRPS GDGTFQKWAA VVVPSGEEQR YTCHVQHKGL PEPVTLRWEP PPQSIIPIIC IIAGLGLLGA VVAGAVIWRK KRSDGRGGSY TQAASSDSAQ GSDVSLKAGE I // ID F7ABB0_ORNAN Unreviewed; 126 AA. AC F7ABB0; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000028412}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000028412, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [2] {ECO:0000313|Ensembl:ENSOANP00000028412} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000028412}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7ABB0; -. DR Ensembl; ENSOANT00000032209; ENSOANP00000028412; ENSOANG00000022269. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7ABB0; -. DR OrthoDB; EOG091G0BU8; -. DR Proteomes; UP000002279; Unplaced. DR Bgee; ENSOANG00000022269; Expressed in 1 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 102 124 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 84 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 126 AA; 14734 MW; 506A9CD7240F1793 CRC64; GSHTFQNVIG CEIQKDNSSK GIFFFGYDGE DYISYDLDKE TWTTKDSVAK ITEQKWNATE AHRKSELLDK CVQTFQDLVK YKKYILDLKG INSCYYYNYY HYYVSSTVLS AGFLCTYLYL LILITV // ID F7AH72_HORSE Unreviewed; 352 AA. AC F7AH72; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 52. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000014973}; GN Name=LOC100050473 {ECO:0000313|Ensembl:ENSECAP00000014973}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000014973, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000014973, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014973, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000014973} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014973}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7AH72; -. DR STRING; 9796.ENSECAP00000014973; -. DR PaxDb; F7AH72; -. DR Ensembl; ENSECAT00000018358; ENSECAP00000014973; ENSECAG00000017324. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7AH72; -. DR OMA; DWARYDC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000017324; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 352 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003353168. FT TRANSMEM 305 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 352 AA; 39772 MW; D69B3D462839740F CRC64; MRLMGPPTFL LLLSGVLVLT RTWAGFHSLR YFHTVVSRPG REDLYVSVGY LDDTQFMRFD SEAASQRVEP RAPWMEQEGP QFWEEQTKIA KEHAHDSKSN LRWVLGFYNQ SESGPHTFQW TSGCDVGTDG RLLRGFEQFA YDGADYIALN EDLRSWTAMD TAAQITQREW EAGGLADHYR LFLEEDCVER LLSYLEKGKE ALQRTDSPKT HVTLHPISDR EVTLRCWALG FYPAEITLTW QCDGEDLTQD TEFVETRPAG DGTFQKWAAV VVPSGEEQRY TCHVQHEGLP EPITWRWEPP LESPILIVGV IAGVGLLGAV VAGVVIWRKK HSGGKRGSYT QSTSSDSAQS PV // ID F7AKC4_HORSE Unreviewed; 360 AA. AC F7AKC4; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 48. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000009264}; GN Name=LOC100056062 {ECO:0000313|Ensembl:ENSECAP00000009264}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000009264, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000009264, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009264, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000009264} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009264}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7AKC4; -. DR STRING; 9796.ENSECAP00000009264; -. DR PaxDb; F7AKC4; -. DR Ensembl; ENSECAT00000011806; ENSECAP00000009264; ENSECAG00000009069. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7AKC4; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000009069; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 360 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003348632. FT TRANSMEM 306 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 360 AA; 40439 MW; CCD744552E1AB204 CRC64; MCVMMPPTFL LLLSGALTLT ETWAGSHSMR YYKTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRME PRARWVEQEG PQYWEEETRT AKGHAQTFRG NLRIALGYYN QSEAGSHTFQ WMSGCDVGPD GRLLRGYSQF AYDGADYIAL NEDLRSWTAA DTAAQITRRK WEAAGEAEQH RNYLEGRCVE WLLRYLENGK ETLQRVDPPK THVTHHPSSD HEVTLRCWAL GFYPAEITLT WQRDGEDLTQ DTEFVATRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPVTRRWEL PPQSTILIVS IIAGLVLLGA VVAGAVIWRK KRSGEKRGIY VQAANSDSAQ GSDASLPQKG // ID F7ANY5_HORSE Unreviewed; 235 AA. AC F7ANY5; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 49. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000009540}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000009540, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000009540, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009540, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000009540} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009540}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7ANY5; -. DR PaxDb; F7ANY5; -. DR Ensembl; ENSECAT00000012113; ENSECAP00000009540; ENSECAG00000011673. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7ANY5; -. DR OMA; ETRITRH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000011673; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 180 207 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 83 169 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 235 AA; 26072 MW; 6355324B4F85BB22 CRC64; YVGPDLCLLR GYRQVAYDGA DFIALNKDLH WTAADTAAQI SRRKWEAAGV VERWSNYLEG TCVEWLLRYL ENGKETLQRA DAPKTHVTHH PISVREVTLR CWALGFYPAE ITLSWQRDGE DLTQDTELVE TRPAGDGTFQ KWAAMVVPSG EEQRYMCHVQ LEGLPEPITQ RWELPPESTI ATLGLIVGLV LLGTVATGAL VAGAVMWRKK RSGEKRGGYL QAASSDSAQG SDVSL // ID F7AYJ9_CALJA Unreviewed; 298 AA. AC F7AYJ9; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 45. DE SubName: Full=Alpha-2-glycoprotein 1, zinc-binding {ECO:0000313|Ensembl:ENSCJAP00000051786}; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSCJAP00000051786}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000051786, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000051786, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000051786} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7AYJ9; -. DR Ensembl; ENSCJAT00000055813; ENSCJAP00000051786; ENSCJAG00000015693. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 298 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015349920. FT DOMAIN 207 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 298 AA; 34168 MW; 0506831C35041886 CRC64; ILRMVPVLLS LLLLLGPAVP QETQDGRYSL TYVYTGLSKP VGDIPKFQAF GFLNDLSFFE YDSEDRRSRP LGPWRQVEGM EDWEQDSQLQ KAREDIFMQT LNDITEYYND SNGSHTLQGR FGCEIQNNRS TGAFWEYTYD ERGYIKFDKE IPAWIPLDPA AHITKQKWEA EPDYVLRAKA YLEKECPATL RKYLNYSKSI LDRQDPPSVM VTSHQAQGED KKLKCLAYSF YPREIDMHWT RAGEVQEPDS GGDVLYSGNG TYQAWVVVQV SPKDTAPYSC YVQHSSLAQP LVVPEDAS // ID F7B408_XENTR Unreviewed; 342 AA. AC F7B408; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000019930}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000019930, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000019930} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000019930}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000019930} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099301; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099302; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099303; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F7B408; -. DR STRING; 8364.ENSXETP00000019930; -. DR PaxDb; F7B408; -. DR Ensembl; ENSXETT00000019930; ENSXETP00000019930; ENSXETG00000009073. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7B408; -. DR OMA; HYLEEEC; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000009073; Expressed in 6 organ(s), highest expression level in embryo. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 342 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003348347. FT TRANSMEM 290 315 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 192 277 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 342 AA; 39016 MW; D6092D93231CD594 CRC64; LLPFMFVLLG SHTLLYHITI VSAPTTGVPQ YSIIMYVDGV QYGRYNSDIR QAETSIPSLR ELSKHIEKQT QYVQEYEMSQ RHKLKFLIGF YNNTKSDRDT HIYQSRLACE LHDDGTIGGY QEIAFDGKAL LIFDKENVTY VPVTQEAEIV AQLWNKHYDS TNTKLYMEND CIEHLKLYLP YISTDLERKV PPNVKVSNSE SESGTKLHCR VYGFYPRDVE VKWIKNGRDE IHSEEAAQIL PNPDGTYQIR VSVGVTPEGG ATYSCHIDHS SLEKPLVVKF DSTEPNNGRY LYIIISVIVT LLLLLLPFAL GLCIYRKRKT KGVAAQTVAT CRDSHSRNIG QR // ID F7B534_XENTR Unreviewed; 266 AA. AC F7B534; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000019918}; DE Flags: Fragment; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000019918, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000019918} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000019918} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099286; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099287; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099288; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 8364.ENSXETP00000019918; -. DR PaxDb; F7B534; -. DR Ensembl; ENSXETT00000019918; ENSXETP00000019918; ENSXETG00000032875. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; EDRTHNT; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000032875; Expressed in 10 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}. FT DOMAIN 169 266 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSXETP00000019918}. SQ SEQUENCE 266 AA; 30486 MW; 1DDFD9671AC055EE CRC64; GSHTLHYHVT IVSAPTPGVP RYLVSMYVDG VQYGRYNSDI RHAEALYPSL GALSEHIEKQ TQYAQGYEMR QRRKLKFLNG YLNKTRGNGN IYQRRLACEL YEDGTIGGYE EIAFDGQELL VYDKERVVYV PVTHEAEMLS FIWNICYGPT DTKLYMENDC IEHIKLYLPY ISTDLERKAV PGNHVTLFSE SESGTKLHCR VYGFYPRDVE VKWIKNGRDE IHSEEAAQIL PNPDGTYQIR VSVGVTLDKN SNYSCLVDHS SLETPI // ID F7BF28_ORNAN Unreviewed; 352 AA. AC F7BF28; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 12-SEP-2018, entry version 50. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000008299}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000008299, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [2] {ECO:0000313|Ensembl:ENSOANP00000008299} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000008299}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7BF28; -. DR STRING; 9258.ENSOANP00000008299; -. DR Ensembl; ENSOANT00000008301; ENSOANP00000008299; ENSOANG00000005224. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7BF28; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002279; Unplaced. DR Bgee; ENSOANG00000005224; Expressed in 5 organ(s), highest expression level in female gonad. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 352 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003354060. FT TRANSMEM 312 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 212 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 170 190 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 352 AA; 39918 MW; 924F14AD0003A485 CRC64; METPALPRLL LFLFLFLGSG RLPATWARSH FLRYFYTAVS RPGPGVPAFT AVGYLDDQQF VRFDSNRQKV EGLTTWIQGG QGPDYWEQQN QELRGTQQIF LQNLQVALSY YNQSEGGYHS YQEMYGCELR TDGSTGKAYD RYGYDGQDYI TLDLDTLTWT AANPEAQYTK RKWEANKKKL ELEKAYLQGQ CVYWISEYLK LGGDSLNRTE PPSVRVTRHP SQDEDNVTLR CQALGFYPAD IRMRWQRDGE DLTRDTEHVE TRPGGDGTFQ KWTAVVGVSH GQEQRYVCVV DHDGLANPLA VGWVSDLSPR KAVIMGALAT VLIVTAVLAG VVILRKRRPG EQQSYYIPAA SE // ID F7BJB5_HORSE Unreviewed; 364 AA. AC F7BJB5; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 48. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000011127}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000011127, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000011127, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011127, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000011127} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011127}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR PaxDb; F7BJB5; -. DR Ensembl; ENSECAT00000013970; ENSECAP00000011127; ENSECAG00000012217. DR eggNOG; ENOG410IGE3; Eukaryota. DR eggNOG; ENOG41114P3; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7BJB5; -. DR OMA; TESWIAP; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000012217; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003354387. FT TRANSMEM 307 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 40548 MW; 5686772B80AC7277 CRC64; IRVMAPGTLL LLLSGALTLT ETWAGSHSMR YFYTAVSRPR GEPRFIAVGY VDDTQFVGFD SDAENPRMEP RAPWMEQEGP EYWEQQTQGI KGTAQNFRVN LNTLRGYYNQ SEAGSHTLQR MYGCDVGPDG RLLRGYWQEG YDGAYYIALN EDLRSWTAAD TAAQITWRKW EAAGVAEQRR NYLEGTCLGC LLRYLEIGKE TLQRADPPKT HVTHNPISDH EVTLWCWVLG FYPAEIALTW QRDGENVTQD TELAETRPAG DGTFQKWAAV VVPSGEEQRY TRHVQHEGLP EPVTLRWEPP PTSTIPFVGI IVGLLLLGAV VAGVVEVCPA WLMSSPIHKH LGYAQAASSD SAQGSDVSLK AGDT // ID F7BN88_HORSE Unreviewed; 240 AA. AC F7BN88; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000016594}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000016594, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000016594, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016594, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000016594} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016594}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7BN88; -. DR PaxDb; F7BN88; -. DR Ensembl; ENSECAT00000020228; ENSECAP00000016594; ENSECAG00000019095. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7BN88; -. DR OMA; KTHITHH; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000019095; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 185 207 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 88 176 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 240 AA; 26694 MW; 54EBB1B49C9729C7 CRC64; MYGCDVGPDG RLLRGYFKSA YDGADYIALN EDLRSWTAAD AAAQITRRKW EAAGVAEQRR NYLEGTCVEW LLRHLENGKE TLQRADPPKT HVTHYSISDR EVTLRCWALG FYPAEITLSW QRDGEDLTQD MELVETRPGG DGNFQKWVAV VVPSGEEQRY TCRVQHEGLA EPITLRWELP PESTILTVGI IVGLLLLGAV VVGVVIWRKK HSGEKGRSYS QAANSDSAQG SDVSLKAGDT // ID F7BRW2_XENTR Unreviewed; 265 AA. AC F7BRW2; F6T5N3; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000019901}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000019901, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000019901} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000019901} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099273; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099274; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F7BRW2; -. DR PaxDb; F7BRW2; -. DR Ensembl; ENSXETT00000019901; ENSXETP00000019901; ENSXETG00000033980. DR GeneTree; ENSGT00740000114936; -. DR OMA; LANRIMF; -. DR OrthoDB; EOG0907079Q; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000033980; Expressed in 9 organ(s), highest expression level in liver. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}. FT DOMAIN 160 245 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 265 AA; 30303 MW; 51B2C183B5A0BAE8 CRC64; MHMAYVDDLR FARYNNEINR CEFWIPALGT LYERMTMQKN YMHNFEISHN QKTKLLTDLY NKTSGKDAIH VYQTKAACEM HEDGTITAYQ EVAFDGKELI AYDYQTETFI PTTPEAQTVA QIWNENYVKL EKVFLENYCT HRLSTYLPAI ASDLEKLVPP KVKVSSSESE SGTKLHCRVY GFYPRDVEVK WIKNGRDEIH SEEAAQILPN PDGTYQIRVS VGVTPEGGAT YSCHIDHSSL EKTLVVPFDP NGSYQSGSTE TDIEN // ID F7BSX5_HORSE Unreviewed; 387 AA. AC F7BSX5; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000020078}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020078, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000020078, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020078, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000020078} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020078}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR PaxDb; F7BSX5; -. DR Ensembl; ENSECAT00000024180; ENSECAP00000020078; ENSECAG00000021750. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7BSX5; -. DR OMA; GYCQEAY; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000021750; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 387 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003354439. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 387 AA; 42881 MW; E9E5A5AF601DE1E8 CRC64; MTVRATRALL LLLSGLALTE TWAGELPLMR YFSTAVSRPC PRGARFIAVG YVDDTQFVRF DSDAASPRME PRAPWMEQEG PEYWERETRT AKGNAQTFRV SLNNLRGYYN QSEAGSHTLQ DMYGCDVGPD GRLLRGYSQY AYDGADYLAL NEDLRSWTAA DTAAQISRRK WEAAGVAEHD RNYLEGTCVE WLLRYLENGK ETLQRADPPK AHVTHHPISD HEVTLRCWAL GFYPADISLS WQRDGEDLTQ DTEFVETRPA GDGTFQKWAA VVVPSGEEQR YTCRVQHEGL PEPVTLRWGK EGASTILIVG VIAGLVLFMV TVAVVVGAVI WRKKRSGGKG GSYAQASSSD SALNSDVSYG SMRQLPCGGL SDTRFLPVPP PIMTSGI // ID F7C2F9_HORSE Unreviewed; 276 AA. AC F7C2F9; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000008920}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000008920, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000008920, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008920, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000008920} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008920}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSECAT00000011411; ENSECAP00000008920; ENSECAG00000009368. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000009368; Expressed in 3 organ(s), highest expression level in liver. DR ExpressionAtlas; F7C2F9; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 224 243 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 124 210 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 276 AA; 30698 MW; 74E563C3AA9B7DC3 CRC64; WTTRSSRGNA QTFRVGLTNL RGYYIQSETG SHTLQWMSGC DVGPDGRLLR GYSQDAYDGA DYIALNEDLR SWTAADTAAQ ITRRKLEAAG VAEDYRKYLE GPCVKWLLRY LENGTETLQR VEPPKTHVTH HRVSDHEVTL RCWALGFYPA EITLSWQRDG EDMTQDTELV ETRPAGDGTF QKWAAVVVPS GEEQRYTCHV QHKGLPEPVT RRWEPSSQPT IPTVGLIAGL VLLAAVVTGA VICRRKRSGR EGRSYTQAAG SDSAQGSDVS LMDPKV // ID F7C2R8_MACMU Unreviewed; 327 AA. AC F7C2R8; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000034120}; GN Name=LOC106996676 {ECO:0000313|Ensembl:ENSMMUP00000034120}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000034120, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000034120, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034120, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000034120} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034120}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030604; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030605; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030606; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030607; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030608; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMMUT00000041087; ENSMMUP00000034120; ENSMMUG00000029841. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000029841; Expressed in 14 organ(s), highest expression level in peripheral blood mononuclear cell. DR ExpressionAtlas; F7C2R8; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 327 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008956473. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 327 AA; 36969 MW; 2158BB04C595BC3E CRC64; MAPRTLLLLL SGALALTETW AGSHSLRYFH TAVSRPGRRE PRFIAVGYVD DTQFVRFDSD AESPREEPQA PWMEQVGPEY WEEQTRIAKG NAQTHRVDLR TLLRYYNQSD AGSHTLQTMY GCDLGPDGRL LRGYHQSAYD GKDYIALNED LRSWTAADMA AQNTQRKWEA ARAAERQRAY LEGRCLEWLR RYLENGKETL QRADPPKTHV IHHSVSDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPGGDG TFQKWGAVVV PSGEEQRYTC HVQHEGLPEP LTLRWGKKGD EGSCLFSGKA GALLDDSAQG SEVSLTA // ID F7C3B3_MACMU Unreviewed; 387 AA. AC F7C3B3; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000034117}; GN Name=LOC106996676 {ECO:0000313|Ensembl:ENSMMUP00000034117}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000034117, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000034117, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034117, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000034117} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034117}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030604; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030605; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030606; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030607; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030608; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMMUT00000041084; ENSMMUP00000034117; ENSMMUG00000029841. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000029841; Expressed in 14 organ(s), highest expression level in peripheral blood mononuclear cell. DR ExpressionAtlas; F7C3B3; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 338 362 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 239 327 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 387 AA; 43364 MW; 5555FB5544882F65 CRC64; MSREANQRRR GLSSTVPTYP PGLRGSSDAE MPVMAPRTLL LLLSGALALT ETWAGSHSLR YFHTAVSRPG RREPRFIAVG YVDDTQFVRF DSDAESPREE PQAPWMEQVG PEYWEEQTRI AKGNAQTHRV DLRTLLRYYN QSDAGSHTLQ TMYGCDLGPD GRLLRGYHQS AYDGKDYIAL NEDLRSWTAA DMAAQNTQRK WEAARAAERQ RAYLEGRCLE WLRRYLENGK ETLQRADPPK THVIHHSVSD HEATLRCWAL GFYPAEITLT WQRDGEEQTQ DTELVETRPG GDGTFQKWGA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQSTNPIVG IVVGLAVLAV VVTGAVVAAV MWRRKSSGRE GVRASDSAQG SEVSLTA // ID F7C3C7_MACMU Unreviewed; 362 AA. AC F7C3C7; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 49. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000034115}; GN Name=LOC106996676 {ECO:0000313|Ensembl:ENSMMUP00000034115}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000034115, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000034115, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034115, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000034115} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034115}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030604; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030605; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030606; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030607; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030608; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9544.ENSMMUP00000034115; -. DR Ensembl; ENSMMUT00000041082; ENSMMUP00000034115; ENSMMUG00000029841. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7C3C7; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000029841; Expressed in 14 organ(s), highest expression level in peripheral blood mononuclear cell. DR ExpressionAtlas; F7C3C7; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003348961. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40562 MW; D53A2D1E9BF60149 CRC64; MPVMAPRTLL LLLSGALALT ETWAGSHSLR YFHTAVSRPG RREPRFIAVG YVDDTQFVRF DSDAESPREE PQAPWMEQVG PEYWEEQTRI AKGNAQTHRV DLRTLLRYYN QSDAGSHTLQ TMYGCDLGPD GRLLRGYHQS AYDGKDYIAL NEDLRSWTAA DMAAQNTQRK WEAARAAERQ RAYLEGRCLE WLRRYLENGK ETLQRADPPK THVIHHSVSD HEATLRCWAL GFYPAEITLT WQRDGEEQTQ DTELVETRPG GDGTFQKWGA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQSTNPIVG IVVGLAVLAV VVTGAVVAAV MWRRKSSGGR GGSYFQAACN DSAQGSEVSL TA // ID F7C7I4_HORSE Unreviewed; 219 AA. AC F7C7I4; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000000182}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000000182, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000000182, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000182, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000000182} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000182}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7C7I4; -. DR STRING; 9796.ENSECAP00000000182; -. DR PaxDb; F7C7I4; -. DR Ensembl; ENSECAT00000000242; ENSECAP00000000182; ENSECAG00000000316. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F7C7I4; -. DR OMA; CKMWLEE; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000002281; Chromosome 31. DR Bgee; ENSECAG00000000316; Expressed in 2 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 197 217 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 5 173 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 219 AA; 24918 MW; 07B009D804554678 CRC64; TDAPSLCYEF TLIPKPSPGQ SWCEVQGQVD EKTFLSYDCG SQEVKSLSLL GEEVKGTRAW QEQVETLRDV GNLLRQQLLD VKPEKHTDRD PLPLQGRMLC QCEANGHTRA SWQFGFHGQM FLLFDSENKT WTVLHPRGRR MKEKWGSDRD VTEFFRKISM GDCRSWLESF LVHWEKMLET TASPTVAAVK GQSRATVITP IAWILLVTLS CSILLGIRG // ID F7CAB8_HORSE Unreviewed; 285 AA. AC F7CAB8; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 51. DE SubName: Full=Alpha-2-glycoprotein 1, zinc-binding {ECO:0000313|Ensembl:ENSECAP00000012712}; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSECAP00000012712, GN ECO:0000313|VGNC:VGNC:15719}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000012712, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000012712, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012712, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000012712} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012712}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR RefSeq; XP_014585352.1; XM_014729866.1. DR ProteinModelPortal; F7CAB8; -. DR STRING; 9796.ENSECAP00000012712; -. DR PaxDb; F7CAB8; -. DR Ensembl; ENSECAT00000015779; ENSECAP00000012712; ENSECAG00000014927. DR GeneID; 100067197; -. DR CTD; 563; -. DR VGNC; VGNC:15719; AZGP1. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7CAB8; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 13. DR Bgee; ENSECAG00000014927; Expressed in 2 organ(s), highest expression level in liver. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 285 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003349136. FT DOMAIN 207 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 285 AA; 32195 MW; A747AC7DB66A4C96 CRC64; MSTMVPVLLP LLLLLGPAVS QETHTGPYSL SFLYTGLSKP AKGFPRFQAI AYLNDQAFFH YDSEGRKAEP LGPWSQVEGM EDWEKESELQ KAREDIFMVT LEDIMDYYKD REGSHTFQGL FGCELRNNQS SGAFWRYAYD GRDFIEFNKE IPAWVALDPA ARDTKQKWEA EEVYVQRAKA YLEEECPGML RRYLQDGRIY LDRQDPPSVS VTSHVAPGKE RTLKCLAYDF YPRRIGLHWT RASDAQETES GGDILPSGNG TYLSWGGGGS PPSGQSPLLL PRGAQ // ID F7CDQ3_MONDO Unreviewed; 340 AA. AC F7CDQ3; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 12-SEP-2018, entry version 53. DE SubName: Full=MHC class I-related protein {ECO:0000313|EMBL:BAM66416.1}; DE SubName: Full=Major histocompatibility complex, class I-related precursor {ECO:0000313|Ensembl:ENSMODP00000008100}; GN Name=MR1 {ECO:0000313|EMBL:BAM66416.1, GN ECO:0000313|Ensembl:ENSMODP00000008100}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000008100, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000008100, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000008100} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000313|EMBL:BAM66416.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Spleen {ECO:0000313|EMBL:BAM66416.1}; RX PubMed=23229473; DOI=10.1007/s00251-012-0666-5; RA Tsukamoto K., Deakin J.E., Graves J.A.M., Hashimoto K.; RT "Exceptionally high conservation of the MHC class I-related gene, MR1, RT among mammals."; RL Immunogenetics 65:115-124(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AB719957; BAM66416.1; -; mRNA. DR RefSeq; NP_001278598.1; NM_001291669.1. DR STRING; 13616.ENSMODP00000008100; -. DR Ensembl; ENSMODT00000008264; ENSMODP00000008100; ENSMODG00000006527. DR GeneID; 100023175; -. DR KEGG; mdo:100023175; -. DR CTD; 3140; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; GYVDSHP; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002280; Chromosome 2. DR Bgee; ENSMODG00000006527; Expressed in 7 organ(s), highest expression level in placenta. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 340 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014090686. FT TRANSMEM 303 322 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 201 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 38965 MW; 699771881FB4D77B CRC64; MIFLFHLLMT SATQGGDART HSLRYFRLGL SDSNQGMPEF ISVGYVDSHP ITSYDSNGRQ KMPQASWMEE NLGSDHWEKY TQLLRGWQQT FKIELRALQN HYNHTGGFHI YQRMIGCELL EDGSTTGFLQ YAYDGKDFIV FNKESLSWIA MDNVARLTKQ AWEANRNELR YQKNWLETEC IAWLKKFLDF GKDTLQRTET PLLSGSCKKS STGITTLICK AYGFYPPEIT MTWIKNGELI TQEIEHGDIL PSGDGTYQTW VSIDIDPQSK DHYSCQVEHN NFLKVLHVPV ELKTISLSPY VEIVSGVIII ASFLIGLGIF VYKRKQSELK EVGYVPTPVK // ID F7CG96_HORSE Unreviewed; 307 AA. AC F7CG96; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000017283}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017283, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000017283, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017283, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000017283} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017283}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7CG96; -. DR PaxDb; F7CG96; -. DR Ensembl; ENSECAT00000021011; ENSECAP00000017283; ENSECAG00000019318. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7CG96; -. DR OMA; MKNATQT; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000019318; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 307 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003350296. FT DOMAIN 206 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 307 AA; 35013 MW; 9D71E44CD44E1BDA CRC64; MRATEVPTFL LLLAGTLTET WAGSHSMRYF YTAVSRPGRG EPRFIAVGYV DDTQFVRFDS DAESPRMQPR APWMEQAGPE YWEEQTQIAQ EAAENFRVNL NTLRGYYNQS EAGSHTIQHM YGCDVGPDGR LLRGYTQFAY DGADYLALNE DLRSWTAADT AAQITRRKWE AAGEAEQRRN YLEGTCVEWL LRYLENGKET LQRAEPLKTH VTHHPISDHE VTLRCWALGF HPAEITLTWQ RDGEDLPQDT ELVETRPAGD GTFQKWAAVV VPSGEEQRYT CHVQHEGLPE PLTLRWEPPP QAAMPIV // ID F7CH32_HORSE Unreviewed; 337 AA. AC F7CH32; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 50. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSECAP00000017258}; GN Name=MR1 {ECO:0000313|Ensembl:ENSECAP00000017258, GN ECO:0000313|VGNC:VGNC:20304}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017258, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000017258, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017258, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000017258} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017258}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR RefSeq; XP_005609819.1; XM_005609762.2. DR ProteinModelPortal; F7CH32; -. DR STRING; 9796.ENSECAP00000017258; -. DR PaxDb; F7CH32; -. DR Ensembl; ENSECAT00000020986; ENSECAP00000017258; ENSECAG00000019491. DR GeneID; 100054060; -. DR KEGG; ecb:100054060; -. DR CTD; 3140; -. DR VGNC; VGNC:20304; MR1. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7CH32; -. DR OMA; GYVDSHP; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 5. DR Bgee; ENSECAG00000019491; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 337 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003350319. FT TRANSMEM 296 319 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 158 178 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 337 AA; 38832 MW; 01807B1179C2B093 CRC64; MVLLVPLIIV LTGKLSDARS HSLRYFRLGV SDPGHGIPEF ISVGYVDSHP ITTYDSVSRR KEPRAPWMAE NLAPDHWERY TQLLRGWQQT FKKELQHLES LYNHSGFHTY QRMIGCELLE DGSTTGFLQY AYDGQDFIIF DKDTLSWTAL DNIAYITKKA WEANRHKLQY EKNWLEEECI AWLKRFLEYG KDTLQRTEPP LVRVNRRETF PGMTTLFCRA HGFYPPEISM IWMKNGEEIV QQVDYGDILP SGDGTYQTWV SVELDAQSSE LYSCHIEHCG LHTVLQVPQE SETIPLVMKA VAGSIVLAIA LTGVGILVWR RRPREQSGVI YLPTPHQ // ID F7CHG1_MONDO Unreviewed; 364 AA. AC F7CHG1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000018565}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000018565, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000018565, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000018565} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7CHG1; -. DR STRING; 13616.ENSMODP00000018565; -. DR Ensembl; ENSMODT00000018898; ENSMODP00000018565; ENSMODG00000014839. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7CHG1; -. DR OMA; VPGYYNQ; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002280; Chromosome 2. DR Bgee; ENSMODG00000014839; Expressed in 8 organ(s), highest expression level in female gonad. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003349514. FT TRANSMEM 306 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 40316 MW; FE7D68FF59AA55D4 CRC64; PGAMKPSLPS LFVLGVVALT ETRAGEEGSV FFHCHGPGPE VRDSQFISVG YVDDQQFVRF DSSSESQRLE LRAAWMDKVD EDYWERQTQI SRRTAQIYGV NLETLLGYYN QSRGGLHTLQ RMLGCEVHPD GSFRKGFDQH AYDGHDYIAL DRETLTWTAA DTGAENTKRK WEAERSFAEG QKAYLEETCV QWLKKYLQMG KDVLLRTDPP SARVSRHSGP DGEVSLRCRA QGFYPAEISL TWLRDGEEQL QDTEFIETRP GGDGTFQKWA AVAMAPGQED RYSCRVQHEA LAQPLSLRWE PEASSLWVIA GVTAGVLVMV TAVVAGAVIL RRRNSGGKGG AYVPAADKDS AQGSDVSLTV TGEA // ID F7CI41_MACMU Unreviewed; 256 AA. AC F7CI41; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 37. DE SubName: Full=Mamu class I histocompatibility antigen, alpha chain F precursor {ECO:0000313|Ensembl:ENSMMUP00000034231}; GN Name=MAMU-F {ECO:0000313|Ensembl:ENSMMUP00000034231}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000034231, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000034231, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034231, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000034231} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034231}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030514; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030515; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMMUT00000041195; ENSMMUP00000034231; ENSMMUG00000008799. DR eggNOG; ENOG410IUXN; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000008799; Expressed in 15 organ(s), highest expression level in CD4-positive helper T cell. DR ExpressionAtlas; F7CI41; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 256 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003349386. FT TRANSMEM 213 239 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 22 202 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 188 208 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 256 AA; 29099 MW; 6EDD38A266048DE3 CRC64; MAPRTLLLVL SGALALTETW AGSHSLRYFS TAVSRPGRRE PQYRYIAVEY VDDTQFLRFD SDAAIPRMEP REPWVEQEGP QYWERTTGYA KANARTDRVA LRKLLLRYNQ SEAGSHTLQG MNGCDMGPDG RLLRGYHQHA YDGKDYISLN EDLRSWTAAD TVARITQRFY EAEEYAEEFR TYLEGECLEL LRRYLENGKE TLQRAESSSQ PTIPIVGIVA GLAVLAVVVT GAVVTAVMWR RKSSDRNRGS YSQPTM // ID F7CIK4_MACMU Unreviewed; 339 AA. AC F7CIK4; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000034225}; GN Name=LOC106995876 {ECO:0000313|Ensembl:ENSMMUP00000034225}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000034225, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000034225, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034225, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000034225} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034225}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030517; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9544.ENSMMUP00000034225; -. DR Ensembl; ENSMMUT00000041189; ENSMMUP00000034225; ENSMMUG00000029875. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7CIK4; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000029875; Expressed in 13 organ(s), highest expression level in CD4-positive helper T cell. DR ExpressionAtlas; F7CIK4; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 339 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008956516. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 339 AA; 38679 MW; DF0F99DCA667E8E5 CRC64; MAVMAPRTLL LVLSGVLALT QTQAGSHSMR YFYTAVSRPG RREPLFIAVG YVDDTQFVRF DSDAESPRME PRAPWVEQEG PEYWDRETQN MKTATQTYRG NLRTALRYYN QSEGGSHTIQ KMYGCDLGPD GRLLRGYEQF AYDGRDYIIL NEDLRSWTAA DMAAQFTQRK WEAARAAEQH RTYLEGECLE WLRRYLENGK ETLQRADPPK THVTHHPVSD YEATLRCWAL GFYPAEITLT WQRDGEEQTE DTELVETRPT GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRFEP FSQSTIPIVG IIAGLVLLGT VVTGAVVAAV MWRRKSSDR // ID F7CJ50_MACMU Unreviewed; 377 AA. AC F7CJ50; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000034218}; GN Name=LOC106995876 {ECO:0000313|Ensembl:ENSMMUP00000034218}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000034218, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000034218, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034218, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000034218} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034218}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030517; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMMUT00000041181; ENSMMUP00000034218; ENSMMUG00000029875. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000029875; Expressed in 13 organ(s), highest expression level in CD4-positive helper T cell. DR ExpressionAtlas; F7CJ50; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 377 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008956518. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 377 AA; 42698 MW; D3BFEC9620D43EA1 CRC64; MAVMAPRTLL LVLSGVLALT QTQAGSHSMR YFYTAVSRPG RREPLFIAVG YVDDTQFVRF DSDAESPRME PRAPWVEQEG PEYWDRETQN MKTATQTYRG NLRTALRYYN QSEGGSHTIQ KMYGCDLGPD GRLLRGYEQF AYDGRDYIIL NEDLRSWTAA DMAAQFTQRK WEAARAAEQH RTYLEGECLE WLRRYLENGK ETLQRADPPK THVTHHPVSD YEATLRCWAL GFYPAEITLT WQRDGEEQTE DTELVETRPT GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRFEP FSQSTIPIVG IIAGLVLLGT VVTGAVVAAV MWRRKSSGEE GVRSSDSSQG SDVSLTACKD SCLVWDCEAR FVHVFSL // ID F7CNU1_MONDO Unreviewed; 364 AA. AC F7CNU1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000004796}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000004796, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000004796, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000004796} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7CNU1; -. DR STRING; 13616.ENSMODP00000004796; -. DR Ensembl; ENSMODT00000004899; ENSMODP00000004796; ENSMODG00000003914. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7CNU1; -. DR OMA; FQRMIGC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002280; Chromosome 2. DR Bgee; ENSMODG00000003914; Expressed in 8 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003349526. FT TRANSMEM 306 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 40943 MW; 82A332D910E4D201 CRC64; MELSLLSLFM LGVVALTQTR AGSHSMRYFH TAMSRPELGD SQFITVGYVD DQQFVRFDSS SESQRMEPRA AWMDKMDEEE PNYWEEQTQI YRKNAQIYRR NLETLRGYYN QSQGGLHTIQ RMIGCEVSAE GSLRKGFYQF AYDGHDYIAL HTETLSWTAA DTGAENTKRK WEPEKSIAES YKAYLEKECT HWLKKYLVMG KDVLLRTDPP SARVTRHRGP DGEVSLRCRA HGFYPAEISL MWLRDGEEQL QDTEFIETRP GGDGTFQKWA AVAMAPGQED RYSCRVQHEA LAQPLSLRWE PEASSLWVIV GVTAGVLVLV TAVVAGAVIL RRRNSGGKGG AYVPAADKDS AQGSDVSLTA TGEA // ID F7CPG3_MACMU Unreviewed; 394 AA. AC F7CPG3; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000034208}; GN Name=LOC715737 {ECO:0000313|Ensembl:ENSMMUP00000034208}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000034208, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000034208, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034208, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000034208} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034208}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030526; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030527; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMMUT00000041172; ENSMMUP00000034208; ENSMMUG00000019888. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000029875; Expressed in 13 organ(s), highest expression level in CD4-positive helper T cell. DR ExpressionAtlas; F7CPG3; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 394 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008956535. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 394 AA; 43936 MW; 83B016FBFE4A570E CRC64; MAIMAPRTLL LVLSGALALT QTRAGSHSMR YFYTSMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWVEQEG PEYWDRETQN MKTATQNAPV ALRNLRGYYN QSEVGSHTFQ RMVGCDLGPD GRLLRGYEQY AYDGRDYIAL NEDLRSWTAA DMAAQNTQRK WEAADVAERM RAYLEGECVE WLPRYLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGKEQR YTCHVQHEGL PKPLTLKWEP SSQSTIPIVG IIAGLVLLGA VVTGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDVSL TACKGETLGG LMCVGCWGEQ WTQLCCGVSL TWMY // ID F7CU44_HORSE Unreviewed; 343 AA. AC F7CU44; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 48. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000015938}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000015938, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000015938, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015938, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000015938} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015938}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7CU44; -. DR PaxDb; F7CU44; -. DR Ensembl; ENSECAT00000019472; ENSECAP00000015938; ENSECAG00000018221. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7CU44; -. DR OMA; NTRICKA; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000018221; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 343 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003349798. FT TRANSMEM 312 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 308 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 343 AA; 38802 MW; 2E5CEC71AD07BF30 CRC64; MRVRAPRTLL LLLSGALALT KTWVGSSHSL RYLHTVFSPP GREEPRIMSV GYVDDTQFMR FDSDAASPSV EPRAPWAEQE GPEYWERETR IYLDTAENFR VELKTFHDYY NQSEDGSHTF QWMYGCDVGL DGRLLRGYSQ IAYDSADFLS LNEDLRSWTA AHPGALIFAH KWEAAGAVER HGIYLESTCV EWLGRFLENG KETLQRADPP KMHVTHHTTS DHEVTLRCWA LGFYPAEITL TWQRDGEDLT QDMELVETRP AGDGTFQKWA AVMVPSGEEQ RYTCHVQHEG LPEPLILRWE PPPQSTISIP GLVVGLVLLG ALVTGGVVAG VVMWRKKRSG REG // ID F7CXU4_MOUSE Unreviewed; 344 AA. AC F7CXU4; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 71. DE SubName: Full=Histocompatibility 2, M region locus 1 {ECO:0000313|EMBL:EDL23299.1, ECO:0000313|Ensembl:ENSMUSP00000040435}; GN Name=H2-M1 {ECO:0000313|EMBL:EDL23299.1, GN ECO:0000313|Ensembl:ENSMUSP00000040435, ECO:0000313|MGI:MGI:95913}; GN ORFNames=mCG_120543 {ECO:0000313|EMBL:EDL23299.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000040435, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|EMBL:EDL23299.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL23299.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [2] {ECO:0000313|EMBL:EDL23299.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL23299.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSMUSP00000040435, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000040435, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000040435} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000040435}; RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC126245; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH466559; EDL23299.1; -; Genomic_DNA. DR RefSeq; NP_808304.2; NM_177636.2. DR UniGene; Mm.246583; -. DR STRING; 10090.ENSMUSP00000040435; -. DR DNASU; 224756; -. DR Ensembl; ENSMUST00000041662; ENSMUSP00000040435; ENSMUSG00000037334. DR GeneID; 224756; -. DR KEGG; mmu:224756; -. DR UCSC; uc008cld.1; mouse. DR CTD; 224756; -. DR MGI; MGI:95913; H2-M1. DR GeneTree; ENSGT00760000118960; -. DR KO; K06751; -. DR OMA; EPITIRW; -. DR OrthoDB; EOG090B089C; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000037334; Expressed in 23 organ(s), highest expression level in cardiac ventricle. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 344 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015091178. FT TRANSMEM 309 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 344 AA; 40194 MW; 71004E55336F0173 CRC64; MKNFESQTLL LLLMITLAIT KHPNGSHTLR YVYTLLSWPG PLEPQLIFLG YVDDTQIMGF NSISENLGVE SRAPWMYETE EFWEKTTDNV VREHYILKEI MRSVLHIYNY SIIGYHTIQK TYGCQVMHRR YFSHGFFKLA FNLHDYITLN EDLKTWRGVG KAGEMLKEMW EKIKYANQVK SFLQITCVNL LHRFLAFGKK SLLRTDTPKI HMTHKIRPDR KTTLRCWAFN FYPPEITLTW QRDGSNQTQD MEMIETRPSG DGTFQKWAAV VVSTGEEHIY TCHVNHEGLS EPITIRWTKH EPPEPTIPFL AIVIALVLGA LLMGAVMTFL IWKRRTRGKK GSWS // ID F7D0L9_XENTR Unreviewed; 362 AA. AC F7D0L9; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 51. DE SubName: Full=Major histocompatibility complex class I antigen {ECO:0000313|Ensembl:ENSXETP00000037199}; GN Name=mhc1a {ECO:0000313|Ensembl:ENSXETP00000037199, GN ECO:0000313|Xenbase:XB-GENE-485307}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000037199, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000037199} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000037199}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000037199} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01121151; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01121152; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01121153; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01121154; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01121155; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01121156; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F7D0L9; -. DR STRING; 8364.ENSXETP00000037199; -. DR PaxDb; F7D0L9; -. DR Ensembl; ENSXETT00000037199; ENSXETP00000037199; ENSXETG00000017065. DR Xenbase; XB-GENE-485307; mhc1a. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7D0L9; -. DR OMA; SALTKTW; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000017065; Expressed in 22 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 314 337 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 215 301 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 41209 MW; 569650F048DC0AB7 CRC64; VYCLLPDLYT VRMDVRLVPL LLTLGVSAVY SGSHSLRYYY TAVSDRAFGL PEFSSVGYVD ETQINRYSSD NGRNEPAAQW MKQNEGPEYW DRQTQNSKGM EAVFKHNVKV GMDRFNQTSG THSFQNMYGC ELREDGSTRG YDQYGYDGRE FMALDTQRWV YVPSVREAQI STQKWNSPEV NEPERERNYQ ENICIESLKR YLGYGQAELE RRVRPHVKIS DHQSDDITEL RCQAYGFYPR EIDVKWVRNG RDDVHSDEAK EILPNPDGSY QLRATAVVTP KEGDSYACHV EHSSLEEKLI VVWPGPNKDG KNNVIIIACV AVAVLMITAA AVGFVLYKKR QEKSGYTETA SNESPASSVA RA // ID F7D3C5_HORSE Unreviewed; 178 AA. AC F7D3C5; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000000345}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000000345, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000000345, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000345, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000000345} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000345}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7D3C5; -. DR PaxDb; F7D3C5; -. DR Ensembl; ENSECAT00000000443; ENSECAP00000000345; ENSECAG00000000560. DR eggNOG; ENOG410JBPA; Eukaryota. DR eggNOG; ENOG411150N; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F7D3C5; -. DR OMA; WENEKEL; -. DR OrthoDB; EOG091G0NI5; -. DR TreeFam; TF339658; -. DR Proteomes; UP000002281; Chromosome 31. DR Bgee; ENSECAG00000000560; Expressed in 1 organ(s), highest expression level in prefrontal cortex. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}. FT DOMAIN 1 170 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 178 AA; 20059 MW; 8403C165E61D8B1D CRC64; HSLCLNLTVK SQARPGQPWC EVQGSVDRKP FLQYDSDNNT FRPVGLLGEK VNATNAWTDL TQTLGEVGQE LRMLLSSLSP SLRAVCLPTL QVKLCCQREA GRYTGASWQF SFNGQTAVFD TMSMNWTVIG PGVRGIQEEW ENSQDLAEHF RKLSAGDCSH WLREFLEHWE KVLEPTGN // ID F7D6E5_ORNAN Unreviewed; 359 AA. AC F7D6E5; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 53. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000005680}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000005680, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [2] {ECO:0000313|Ensembl:ENSOANP00000005680} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000005680}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7D6E5; -. DR STRING; 9258.ENSOANP00000005680; -. DR Ensembl; ENSOANT00000005682; ENSOANP00000005680; ENSOANG00000003581. DR eggNOG; ENOG410IGE3; Eukaryota. DR eggNOG; ENOG41114P3; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7D6E5; -. DR OMA; RMFGCEI; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002279; Unplaced. DR Bgee; ENSOANG00000003581; Expressed in 4 organ(s), highest expression level in female gonad. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 307 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 41512 MW; 88E68368F5DE2D77 CRC64; MLRISQLKVQ VSRLWGSVQF HFLFSWKGSQ SLHYFFLTMS SSSLEVPNFV SVGYVNDELF IWYDSRTHLA EARAPWMSAM KAEYWERENQ NQRAWEKVQR AEIQAIMRNL NHSGGSHSIQ RMFGCEIHED NSTSVFWHFG YDGEDHLTLD LDTLTWISAN PLAQDTKKWS EQEVCYAQYN KAYLQGLCLT SLLRYLELGR GRLNRKVPPV VRVTRHLAHN GEPMLRCWAH GFYPRDIRLS WWWDGQELTQ ETEHVGSRPG GDGTYQSWGA VEVPSGEEHR YTCRVEHLGL ERPLTVTWEP PIDPSPIFTG AVVVLALSIV AAVTWMRRKR RKRPVSDSGS PSHLDCKPHI KLSDLPILC // ID F7DB76_HORSE Unreviewed; 343 AA. AC F7DB76; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000008796}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000008796, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000008796, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008796, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000008796} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008796}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9796.ENSECAP00000008796; -. DR PaxDb; F7DB76; -. DR Ensembl; ENSECAT00000011275; ENSECAP00000008796; ENSECAG00000008977. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7DB76; -. DR OMA; WMEREGR; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000008977; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 343 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003356066. FT TRANSMEM 305 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 343 AA; 38907 MW; 445DB8A9F11D88C4 CRC64; TVMALRTLLL LLSGTLALTE TLAGSHSMRY FHTAVSRPGR GEPRYLEVGY VDDTQFVRFD SDAASPRMEP RAPWVQQEGP EYWEEETRRA KDLIQNFRRN LLTLRDYYNQ SEAGSHAFQL TYGCEVGSHG PLLRGYWQYS YDGADYIALK EDLRSWTAAD AAAQITRRKW EASLAHERFR GYLEGTCVKW LRRYLENGKE MLQRTESPKT HVTRHPISDH EVTLRCWALG FYPAEITLTW QRDGEDLTQD TELVETRPAG DGTFQKWAAV VVPSGEEQRY TCHVQHQGLP EPVTLRWKPP LESTILIVGV IAGLGLLVAV VAGAVMWRKK RSGGKGGSYT QAA // ID F7DH75_XENTR Unreviewed; 346 AA. AC F7DH75; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000060129}; GN Name=mhc1b2 {ECO:0000313|Ensembl:ENSXETP00000060129}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000060129, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000060129} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000060129} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099269; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099270; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099271; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F7DH75; -. DR STRING; 8364.ENSXETP00000060129; -. DR PaxDb; F7DH75; -. DR Ensembl; ENSXETT00000064404; ENSXETP00000060129; ENSXETG00000014445. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7DH75; -. DR OMA; EYFRAYV; -. DR OrthoDB; EOG091G0BU8; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000014445; Expressed in 9 organ(s), highest expression level in liver. DR ExpressionAtlas; F7DH75; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 346 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003351304. FT TRANSMEM 302 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 346 AA; 38931 MW; E0E6C6F2BA0F24EB CRC64; GNMAGILPLV CLIFSLGTSV VYSGSHTLRF HVTKLTAPYP GFPDYMLLAY VDDLRFARYN NELNRCEFWI PALGALNERI TKQKNYTHNF KISHHQKTKL LTDLYNKTSG KDAIHVYQTK SACVMHEDGT ISAYQEVAFN GKELIAYDYQ MGTFIPTTPE AQVAAQVWNE DYAKIEKVFL ENFCTHRLSW YLPALASHLE KLVPPKVKVS ISESDSGAEL HCRVYGFYPR DVEVKWIKNG RDEIHSEEAA QILPNPDGTY QIRVSVGVTP EGGATYSCHV EHSSLEKTLV VPFGYRLRIS LVAIHVAVML LLLNILVTAK FLIKAGQRHN PNGSYQSGST ETDIEN // ID F7DJY2_MACMU Unreviewed; 210 AA. AC F7DJY2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 43. DE SubName: Full=UL16 binding protein 1 {ECO:0000313|Ensembl:ENSMMUP00000009193}; GN Name=ULBP1 {ECO:0000313|Ensembl:ENSMMUP00000009193}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000009193, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000009193, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000009193, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000009193} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000009193}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03031936; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9544.ENSMMUP00000009193; -. DR Ensembl; ENSMMUT00000009788; ENSMMUP00000009193; ENSMMUG00000000923. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F7DJY2; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000000923; Expressed in 10 organ(s), highest expression level in colon. DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl. DR GO; GO:0046658; C:anchored component of plasma membrane; IEA:Ensembl. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 210 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008956627. FT DOMAIN 45 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 210 AA; 24209 MW; EE6BEE3B771F000D CRC64; MAAAASPAFL LCLSFLHLLS GWSRAGRADT HCLCYDFIII PKFRPEPRWC AVQGLVDERP FLHYDCVNHK AKAFASLGKK VNVTKTWEKQ TETLGDVVDF LKGQLPDIQV ENLMPIEPLI LQARMSCEHE AQGHGRGSWQ FLFNGQTFLL FDSNNRKWTA LQPGAKKMKE KWEKNTEVTT FFQKISMGDC KTWLEEFLMY WEQMLDPTSK // ID F7DKE9_CALJA Unreviewed; 279 AA. AC F7DKE9; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 12-SEP-2018, entry version 48. DE SubName: Full=Hemochromatosis {ECO:0000313|Ensembl:ENSCJAP00000020298}; GN Name=HFE {ECO:0000313|Ensembl:ENSCJAP00000020298}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000020298, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000020298, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000020298} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7DKE9; -. DR Ensembl; ENSCJAT00000021443; ENSCJAP00000020298; ENSCJAG00000010993. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl. DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:Ensembl. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl. DR GO; GO:0030881; F:beta-2-microglobulin binding; IEA:Ensembl. DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl. DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0071281; P:cellular response to iron ion; IEA:Ensembl. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:Ensembl. DR GO; GO:1904283; P:negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:Ensembl. DR GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; IEA:Ensembl. DR GO; GO:1900121; P:negative regulation of receptor binding; IEA:Ensembl. DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; IEA:Ensembl. DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR GO; GO:1904434; P:positive regulation of ferrous iron binding; IEA:Ensembl. DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl. DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IEA:Ensembl. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; IEA:Ensembl. DR GO; GO:1900390; P:regulation of iron ion import; IEA:Ensembl. DR GO; GO:2000008; P:regulation of protein localization to cell surface; IEA:Ensembl. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 279 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015359654. FT DOMAIN 27 200 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 279 AA; 31760 MW; 3E7EEF0D5A271AF6 CRC64; MSPRARPALL LLMLLQTAVP QGRLLRSHSL HYLFMGASEQ DLGLSLFEAL GYVDDQLFVF YDHESRRVEP RTPWVSSRTS SQMWLQLSQS LKGWDHMFTV DFWTIMDNHN HSKESHTLQV ILGCEMQEDN STKGFWKYGY DGQDHLEFCS DTLDWRAAEP RAWPTKLEWE AHKIRARQNR AYLERDCPAQ LQQLLELGRG VLDQQGNESS SLPGKGKKIP TRPGAVAQAC NPSTLGGRGG WMTRSKDRDH PGQHGETPSL LKIQKIRGAV GQYVLAECE // ID F7DS92_MACMU Unreviewed; 359 AA. AC F7DS92; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 60. DE SubName: Full=IgG receptor FcRn large subunit p51 precursor {ECO:0000313|Ensembl:ENSMMUP00000016100}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSMMUP00000016100}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000016100, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000016100, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000016100, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000016100} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000016100}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03022116; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03022117; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F7DS92; -. DR STRING; 9544.ENSMMUP00000016100; -. DR Ensembl; ENSMMUT00000017191; ENSMMUP00000016100; ENSMMUG00000012273. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G0KJB; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Chromosome 19. DR Bgee; ENSMMUG00000012273; Expressed in 14 organ(s), highest expression level in lung. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; IBA:GO_Central. DR GO; GO:0019864; F:IgG binding; IEA:Ensembl. DR GO; GO:0019770; F:IgG receptor activity; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 292 315 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 196 283 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 38932 MW; 1A79A1AD17729FF6 CRC64; ARTPRSEGGG AGALSLSAES HLSLLYHLTA VSSPAPGTPA FWVSGWLGPQ QYLSYDSLRG QAEPCGAWVW ENQVSWYWEK ETTDLRIKEK LFLEAFKALG GKGPYTLQGL LGCELSPDNT SVPTAKFALN GEEFMNFDLK QGTWGGDWPE ALAISQRWQQ QDKAANKELT FLLFSCPHRL REHLERGRGN LEWKEPPSMR LKARPGNPGF SVLTCSAFSF YPPELQLRFL RNGMAAGTGQ GDFGPNSDGS FHASSSLTVK SGDEHHYCCI VQHAGLAQPL RVELETPAKS SVLVVGIVIG VLLLTAAAVG GALLWRRMRS GLPAPWISLR GDDTGSLLPT PGEAQDADSK DINVIPATA // ID F7DXG2_HORSE Unreviewed; 359 AA. AC F7DXG2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 49. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000017390}; GN Name=EQMCE1 {ECO:0000313|Ensembl:ENSECAP00000017390}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017390, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000017390, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017390, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000017390} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017390}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9796.ENSECAP00000017390; -. DR PaxDb; F7DXG2; -. DR Ensembl; ENSECAT00000021134; ENSECAP00000017390; ENSECAG00000019474. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7DXG2; -. DR OMA; WDRNTRN; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000019474; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 359 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003350783. FT TRANSMEM 301 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 204 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 40413 MW; C027718A4BB5ECBF CRC64; MDPRTFLLLL SGALTLTKTW AGSHSLRYFN TALSRPAAGA PLHQRRYVDD TQFVRFDSDA ENPRMEPAPW VEQEGPEYWE ENTRTIKSTA QNFRVSLNNL RGYYNQSEAG SHTIQEMYGC DVGPDGRLLR GYSQSAYDGA DYIALNEDLR SWTAADAAAQ ITRRKWEAES VAEQDRAYLD GKCVVWLRRY LEIGKEMLQR ADPPKTHVTR HPISDREVTL RCWALGFYPA EITLTWQRDG EDLTQDTELV ETRPAGDGTF QKWAAVVVPS GEEQRYTCRV QHEGLPEPIT RRWEPPPQST ILIVGVLAGL GLFMVTVAVV VGAVIWRKKR SGGKRGSYAQ STSSDSSQDS DVSLIPPKV // ID F7DZ14_HORSE Unreviewed; 352 AA. AC F7DZ14; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 51. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000014009}; GN Name=LOC100054448 {ECO:0000313|Ensembl:ENSECAP00000014009}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000014009, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000014009, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014009, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000014009} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014009}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR RefSeq; XP_014590149.1; XM_014734663.1. DR ProteinModelPortal; F7DZ14; -. DR STRING; 9796.ENSECAP00000014009; -. DR PaxDb; F7DZ14; -. DR Ensembl; ENSECAT00000017262; ENSECAP00000014009; ENSECAG00000016442. DR GeneID; 100054448; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7DZ14; -. DR OMA; SALTKTW; -. DR OrthoDB; EOG091G0BBK; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000016442; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 352 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003356713. FT TRANSMEM 309 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 307 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 352 AA; 40035 MW; 443A256B70F2B5D5 CRC64; MRVRGPRTLL LLLSGTLTLT KTWAGSHSLR YFYTAVSRPG RGKPRFIAVG YVDDTQFQRF DSGAASPRAE PRAPWMEQEG PEYWEEETRN YKDIAHNFRV ELNVLPDYYN LSKAGSHTFQ WMHGCYVDSD GRLLRGYSQF AYDGDDYLTL NEDLHSWTVA DIAAQITLHK WEASGVVERH KAYVKDKCVK WLLRHLENGK ETLQRIEPPK THVTCHPISN HEVTLRCWAL GFYPAEITLT WQRDGEDLTQ DTELVETRPA GDGTFQKWAA VMVPSGEKQR YMCRVQHEGL PEPVILRWEV PLESTISTVG IVVLAVLVVV VIGVLVAGGR SAQQRHCPRL SCVCPVLVNT KL // ID F7E2N0_HORSE Unreviewed; 310 AA. AC F7E2N0; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000017041}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017041, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000017041, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017041, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000017041} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017041}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7E2N0; -. DR STRING; 9796.ENSECAP00000017041; -. DR PaxDb; F7E2N0; -. DR Ensembl; ENSECAT00000020746; ENSECAP00000017041; ENSECAG00000019052. DR eggNOG; ENOG410J90V; Eukaryota. DR eggNOG; ENOG41117CA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7E2N0; -. DR OMA; TSRMKIF; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000019052; Expressed in 2 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 278 300 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 183 267 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 310 AA; 35795 MW; 8957A015505CF5CD CRC64; SGSHSLQYFY SAVSEPGPGV PAFTAFGFMD GQPFIRYDSE EMKAKSCVQW LMEEPSYFDD ETNIFTSRMK IFQLNLRNVQ RYYNQTQAGP HVLQFTYGCE LREDGSTTWH WQYGYNGDDY LRLDMDPLQY TAVSLIAQFT KQKWEASGNF IERDKIYLEK ECILWLRRYL EFGGESLNRT EPPRTHVTHH PISHRKVTLR CWALGFYPAE ITLTWQHDGE IQDTEFVDTR PAGDGTFQKW AAVVVPSGEE QRYTCHVQHD SSQRNQDPFW RPTAGATIPI AGIFVVLVFL GVVVCGAAVV RSVNWRKETL // ID F7ECK2_XENTR Unreviewed; 348 AA. AC F7ECK2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000063559}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000063559, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000063559} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000063559}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000063559} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099269; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099270; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099271; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099272; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PaxDb; F7ECK2; -. DR Ensembl; ENSXETT00000062953; ENSXETP00000063559; ENSXETG00000030073. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7ECK2; -. DR OMA; EINRCEY; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000030073; Expressed in 9 organ(s), highest expression level in liver. DR ExpressionAtlas; F7ECK2; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 348 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003357051. FT TRANSMEM 301 324 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 348 AA; 39409 MW; 63C2889E23FC982C CRC64; GNMAGILPLV FLIFSLGTSV VYSGSHTLKL YITKLTAPYP GLPDYLHMAY VDDLRYARYN KEINRCEYWI PALGAKWEPM TMQKNYMHNF EISHHQKTKL LTDLYNKTSG KDAIHVYQTK SACEMHEDGT ITAYQEVAFD GKELIAYDYQ TGTFIPTTPE AQIVAQIWNK NYAKIEKIFL EKFCTNRLSK YLNALASDLE KLAVPPKVKV SSSESESGTK LHCRVYGFYP RDVEVKWIKN GRDEIHSEEA AQILPNPDGT YQIRVSVGVT PEGGATYSCH IDHSSLEKTL VVPFEYNNRS ILYIIIPICA ALLLLMIGLG LFLFKKGKKE SHSNGAAYSY TWVTDIGR // ID F7EWE4_RAT Unreviewed; 367 AA. AC F7EWE4; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 12-SEP-2018, entry version 23. DE SubName: Full=RT1 class I, locus CE10 {ECO:0000313|Ensembl:ENSRNOP00000039057}; GN Name=RT1-CE10 {ECO:0000313|Ensembl:ENSRNOP00000039057, GN ECO:0000313|RGD:1359292}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000039057, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000039057, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000039057, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000039057} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000039057}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044242; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSRNOT00000048858; ENSRNOP00000039057; ENSRNOG00000050210. DR RGD; 1359292; RT1-CE10. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR OMA; VTHHPVF; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000050210; Expressed in 9 organ(s), highest expression level in spleen. DR ExpressionAtlas; F7EWE4; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F7EWE4}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 367 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003351596. FT TRANSMEM 312 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 367 AA; 41605 MW; 719CFFE10E7C18EB CRC64; MARPTLLLLL AAALAPTKTR AGSHWMRYFH TAVSRPGLGE PRYISVGYVD DTQFVRFDSD AENPRYEPRA RWMEREGPEY WERNTRIVKG KEQIFRDNLR TLLGYYNQSE GGSHTLQLMY GCDVGSDWSL LRGYEQHAYD GRDYIALNED LKTWAAADFE AQKTRSKWER EGVAERSRAY LEGECVKWLR RHLEHGKEAL LRLDPPEAHV TLHPRPEGDV TLRCWALGFY PADITLTWQL NGEDLTQDME FVETRPAGDG TFQKWASVVV PLGKEQNYTC LVEHEGLPEP LTQRWEPSPS TNTNMGIDVT SVFLGPLAVF VVLAIIGAAV AVVRRRRRRN TGGEGGDYTP APGRDSSSSD VSLPDCK // ID F7EY50_CALJA Unreviewed; 273 AA. AC F7EY50; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 44. DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSCJAP00000000117}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000000117, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000000117, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000000117} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7EY50; -. DR STRING; 9483.ENSCJAP00000000117; -. DR Ensembl; ENSCJAT00000000121; ENSCJAP00000000117; ENSCJAG00000000066. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7EY50; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 273 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015306564. FT TRANSMEM 206 229 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 110 197 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 273 AA; 29278 MW; 5BA4D9E295FF9297 CRC64; MGLPRPQPWV LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWAS GWLGPQQYLS YSSLRGQAEP CGAWVWENQV SWYWEKETTD LRMKEKLFLE AFKALDGKEP PSMRLKARPG SPGFSVLTCS AFSFYPPELQ LRFQRNGLAA GTGEGDFGPN GDGSFHAWSS LTVKSGDEHH YCCIVQHAGL AQPLRVELES PAKSSVLVVG IVVGVLLLTA VAVGGALLWR RMQSGLPAPW ISLRGDDAGA LLPTPGEAQD ADWKGANSAP ATA // ID F7F1S2_MACMU Unreviewed; 443 AA. AC F7F1S2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=Mamu class I histocompatibility antigen, alpha chain F precursor {ECO:0000313|Ensembl:ENSMMUP00000011542}; GN Name=MAMU-F {ECO:0000313|Ensembl:ENSMMUP00000011542}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000011542, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000011542, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000011542, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000011542} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000011542}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030514; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030515; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMMUT00000012304; ENSMMUP00000011542; ENSMMUG00000008799. DR eggNOG; ENOG410IUXN; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000008799; Expressed in 15 organ(s), highest expression level in CD4-positive helper T cell. DR ExpressionAtlas; F7F1S2; baseline. DR GO; GO:0009986; C:cell surface; IEA:Ensembl. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0046978; F:TAP1 binding; IEA:Ensembl. DR GO; GO:0046979; F:TAP2 binding; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 443 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008956832. FT TRANSMEM 307 331 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 352 374 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 394 416 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 443 AA; 50721 MW; BD83F448A1E1414A CRC64; MAPRTLLLVL SGALALTETW AGSHSLRYFS TAVSRPGRRE PQYRYIAVEY VDDTQFLRFD SDAAIPRMEP REPWVEQEGP QYWERTTGYA KANARTDRVA LRKLLLRYNQ SEAGSHTLQG MNGCDMGPDG RLLRGYHQHA YDGKDYISLN EDLRSWTAAD TVARITQRFY EAEEYAEEFR TYLEGECLEL LRRYLENGKE TLQRADPPKA HVAHHPISDR EATLRCWALG FYPAEITLTW QRDGEEQTQD TELVETRPAG DGTFQKWAAV VVPSGEEQRY TCHVQHEGLP QPLTLRWESS SQPTIPIVGI VAGLAVLAVV VTGAVVTAVM WRRKSSDRNR GSYSQPTSKY EGVGSGNLMI VWWLSLFLLG VLFQGYFGCL QSPGVLGCWK VGDVWIFFFL WLWTSFNTAF LAFQSLRFGF GFRRGRSFLL GFWRHLMKRV QIR // ID Q5TM81_MACMU Unreviewed; 348 AA. AC Q5TM81; F7F1S7; DT 21-DEC-2004, integrated into UniProtKB/TrEMBL. DT 21-DEC-2004, sequence version 1. DT 12-SEP-2018, entry version 113. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:ABZ91885.1}; DE SubName: Full=MHC class I protein {ECO:0000313|EMBL:SNR13791.1}; DE SubName: Full=Major histocompatibility complex, class I, F {ECO:0000313|EMBL:BAD69784.1}; DE SubName: Full=Mamu class I histocompatibility antigen, alpha chain F precursor {ECO:0000313|Ensembl:ENSMMUP00000011541}; GN Name=Mamu-F {ECO:0000313|EMBL:BAD69784.1}; GN Synonyms=MAMU-F {ECO:0000313|Ensembl:ENSMMUP00000011541}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|EMBL:BAD69784.1}; RN [1] {ECO:0000313|EMBL:BAD69784.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=15269276; DOI=10.1093/molbev/msh216; RA Kulski J.K., Anzai T., Shiina T., Inoko H.; RT "Rhesus macaque class I duplicon structures, organization, and RT evolution within the alpha block of the major histocompatibility RT complex."; RL Mol. Biol. Evol. 21:2079-2091(2004). RN [2] {ECO:0000313|EMBL:BAD69784.1} RP NUCLEOTIDE SEQUENCE. RA Fukami-Kobayashi K., Shiina T., Anzai T., Sano K., Yamazaki M., RA Inoko H., Tateno Y.; RT "Genomic evolution of MHC class I region in primates."; RL Proc. Natl. Acad. Sci. U.S.A. 102:9230-9234(2005). RN [3] {ECO:0000313|EMBL:BAD69784.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16702430; DOI=10.1534/genetics.106.057034; RA Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., RA Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., RA Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., RA Meyer A., Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., RA Gojobori T., Inoko H., Bahram S.; RT "Rapid evolution of major histocompatibility complex class I genes in RT primates generates new disease alleles in humans via hitchhiking RT diversity."; RL Genetics 173:1555-1570(2006). RN [4] {ECO:0000313|Ensembl:ENSMMUP00000011541, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000011541, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [5] {ECO:0000313|EMBL:ABZ91885.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Peripheral blood {ECO:0000313|EMBL:ABZ91885.1}; RA Wallace L.T., Rudersdorf R., Watkins D.I.; RT "MHC class I genes of the Indian rhesus macaque."; RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|Ensembl:ENSMMUP00000011541} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000011541}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [7] {ECO:0000313|EMBL:SNR13791.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=96084 {ECO:0000313|EMBL:SNR13791.1}, and RC 9910010Y {ECO:0000313|EMBL:SNR13792.1}; RA Sun Z.S., Albrecht U., Echele G., Lee C.C.; RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030514; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030515; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; EU305657; ABZ91885.1; -; mRNA. DR EMBL; AB128049; BAD69784.1; -; Genomic_DNA. DR EMBL; AB128841; BAD77866.1; -; Genomic_DNA. DR EMBL; LT899416; SNR13791.1; -; mRNA. DR EMBL; LT899417; SNR13792.1; -; mRNA. DR UniGene; Mmu.3379; -. DR Ensembl; ENSMMUT00000012303; ENSMMUP00000011541; ENSMMUG00000008799. DR eggNOG; ENOG410IUXN; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000008799; Expressed in 15 organ(s), highest expression level in CD4-positive helper T cell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 348 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015098037. FT TRANSMEM 307 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 348 AA; 39569 MW; 03ED262A2E04E5DD CRC64; MAPRTLLLVL SGALALTETW AGSHSLRYFS TAVSRPGRRE PQYRYIAVEY VDDTQFLRFD SDAAIPRMEP REPWVEQEGP QYWERTTGYA KANARTDRVA LRKLLLRYNQ SEAGSHTLQG MNGCDMGPDG RLLRGYHQHA YDGKDYISLN EDLRSWTAAD TVARITQRFY EAEEYAEEFR TYLEGECLEL LRRYLENGKE TLQRADPPKA HVAHHPISDR EATLRCWALG FYPAEITLTW QRDGEEQTQD TELVETRPAG DGTFQKWAAV VVPSGEEQRY TCHVQHEGLP QPLTLRWESS SQPTIPIVGI VAGLAVLAVV VTGAVVTAVM WRRKSSDRNR GSYSQPTM // ID F7F5U0_RAT Unreviewed; 216 AA. AC F7F5U0; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 3. DT 12-SEP-2018, entry version 58. DE SubName: Full=RT1 class I, locus M6, gene 1 {ECO:0000313|Ensembl:ENSRNOP00000046444}; DE Flags: Fragment; GN Name=RT1-M6-1 {ECO:0000313|Ensembl:ENSRNOP00000046444, GN ECO:0000313|RGD:1598232}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000046444, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000046444, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000046444, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000046444} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000046444}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC108572; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; F7F5U0; -. DR Ensembl; ENSRNOT00000040634; ENSRNOP00000046444; ENSRNOG00000022107. DR RGD; 1598232; RT1-M6-1. DR GeneTree; ENSGT00760000118960; -. DR TreeFam; TF336617; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000022107; Expressed in 9 organ(s), highest expression level in testis. DR ExpressionAtlas; F7F5U0; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 184 208 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 90 178 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 216 216 {ECO:0000313|Ensembl:ENSRNOP00000046444}. SQ SEQUENCE 216 AA; 24353 MW; 07C3A3B71D68B823 CRC64; MQYLVTTTSS QPGLQDSHVC IVGHVDYMPF MRFDSDGAAQ RIQTRGPWMK QMGPEYLEME RKNAEGYSHR ARENLRFAIQ VYNQSDKDPP KAHVTLHPRP EGDVTLRCWA LGFYPADITL TWQLNGEDLT QDMELVETRP AGDGTFQKWA SVVVPNGEEQ KYTCLVEHEG LPEPLTLRWK PATWPVVGIT VGVVLLGFVI IGALIAIVTM RKKRAG // ID F7F763_ORNAN Unreviewed; 199 AA. AC F7F763; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000002957}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000002957, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [2] {ECO:0000313|Ensembl:ENSOANP00000002957} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000002957}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7F763; -. DR STRING; 9258.ENSOANP00000002957; -. DR Ensembl; ENSOANT00000002958; ENSOANP00000002957; ENSOANG00000001863. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7F763; -. DR OMA; EREACPR; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF342059; -. DR Proteomes; UP000002279; Unplaced. DR Bgee; ENSOANG00000001863; Expressed in 6 organ(s), highest expression level in female gonad. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 199 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003352006. FT DOMAIN 21 196 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 53 73 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 199 AA; 23201 MW; 0F2EE1883806F740 CRC64; SLIYFNICLF LSIQLPLSPV GSHSLQFFSF GVSEPGPRVP EYIVFGYLDD QLIARYDSEK RRVEARAKWM EEKEGPKFWD SQTLRGLSWQ SRVMKYLNTI MGYYNHSGGS HTFQHVVGCE IRGDGSTRGV RQYAYDGQDY IFYDTETRTW AAANPVAKIT KRLWEADTAH EAQRKFDLEH ECVYFLQKFL KYATKHLGR // ID F7FE89_MONDO Unreviewed; 357 AA. AC F7FE89; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 12-SEP-2018, entry version 50. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000019728}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000019728, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000019728, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000019728} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7FE89; -. DR Ensembl; ENSMODT00000020082; ENSMODP00000019728; ENSMODG00000015810. DR GeneTree; ENSGT00740000114936; -. DR OMA; ALAMCEF; -. DR TreeFam; TF342166; -. DR Proteomes; UP000002280; Chromosome 2. DR Bgee; ENSMODG00000015810; Expressed in 7 organ(s), highest expression level in female gonad. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0098711; P:iron ion import across plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 31 {ECO:0000256|SAM:SignalP}. FT CHAIN 32 357 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003352021. FT TRANSMEM 319 341 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 219 306 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 357 AA; 40441 MW; 9B1FFA8BF019ADB4 CRC64; MGVIRVPRPL AAAQLGLLLL LQLLQPAQTA AAGTSSHYLR YDFAIVSQPS QGQSSYTVLG YLDGQPFVWC CRQGQRAEPR APWSQVQGPR SWERLIRSLK TVAQRLVIDL KSMMGTKETE KVWNGEAPGS HTLQALAMCE FQGNQSNPGF WRYGYDGQEL ILDLEMLNLT ETESKRQEEI RKYQRRANLE QDFLVRTCLH PLRKYLEAGV LTLQKTVPPS VRVTHHGTFS KKSTLKCQAF SFYPPDISLT WLQDGKPTIK GTQESQSVRP QGDGTYQSYV NVEVPSEEES RYACLVEHQA LNGTFTGIWE PPPPKLPPIW ILSGCLASAL VFVGTTIVFI WRRWKRKRTG FRTKENV // ID F7FNX2_ORNAN Unreviewed; 296 AA. AC F7FNX2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000019341}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000019341, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [2] {ECO:0000313|Ensembl:ENSOANP00000019341} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000019341}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7FNX2; -. DR Ensembl; ENSOANT00000019344; ENSOANP00000019341; ENSOANG00000012222. DR eggNOG; ENOG410IZF6; Eukaryota. DR eggNOG; ENOG41119ST; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7FNX2; -. DR OMA; NETEKTH; -. DR OrthoDB; EOG091G0HHE; -. DR TreeFam; TF352056; -. DR Proteomes; UP000002279; Unplaced. DR Bgee; ENSOANG00000012222; Expressed in 5 organ(s), highest expression level in female gonad. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 263 290 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 161 242 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 296 AA; 33515 MW; C9CB5401855A2D71 CRC64; VVRLDGQQVL YYDSTRRELV LKLGWLYRAL GARRIREKQQ KLKAYEEDFR WAVENWMSKH NESGGTHIVQ VLVGCEMDGD TQVGSSFKFA YNGMDFCWLD ELQGGWVAAS PAVLRFEPFQ QESTFWSKGV RSYVKEECVT LMRHALRYWQ LRELCEWKTP PEVTVTRKDA PDGSLTLSCL ATGFYPSSIL LRWVKDGEKG LWGEESSSGT LPNADDTFYL RQTLELRAEV GDSSYVCLVE HSTLGVPTAY PGMGSVTPRK PTWWIPWSLA LGVAAAAGLV LSPAVGFILW RKKKQG // ID F7FS21_MONDO Unreviewed; 207 AA. AC F7FS21; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 12-SEP-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000019708}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000019708, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000019708, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000019708} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7FS21; -. DR Ensembl; ENSMODT00000020062; ENSMODP00000019708; ENSMODG00000015798. DR OrthoDB; EOG091G1FPA; -. DR TreeFam; TF342059; -. DR Proteomes; UP000002280; Chromosome 2. DR Bgee; ENSMODG00000015798; Expressed in 7 organ(s), highest expression level in liver. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}. FT DOMAIN 24 168 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 53 80 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 207 AA; 23614 MW; 8F502F29C8BA35F3 CRC64; LLFLSSSDFS TLRYNLTLAY FGWNKTSSYI ISGFINDNKF LTYDSKSRHV DFKSCEKADI QNLKEENKEL RDIVSNIALR NGENGGSHTL QVTYGCKRIN GDVKGFWHYI YDGQKFLSFS LEDGSWIGTG PEAEEAKKIL QKSHSQKKVK AYILGDCPAD LKKCLKYQEC VKKTGIEHLE PGLPTHISQE LPSFCLWFCL SWEGDTE // ID F7FS30_MONDO Unreviewed; 176 AA. AC F7FS30; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000019705}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000019705, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000019705, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000019705} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSMODT00000020059; ENSMODP00000019705; ENSMODG00000015796. DR eggNOG; ENOG410KI2N; Eukaryota. DR eggNOG; ENOG4110QPC; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7FS30; -. DR OMA; WKGILER; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF342059; -. DR Proteomes; UP000002280; Chromosome 2. DR Bgee; ENSMODG00000015796; Expressed in 7 organ(s), highest expression level in female gonad. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}. FT DOMAIN 3 170 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 176 AA; 20758 MW; A60FF065543C7C69 CRC64; PASLQYDLTV LSQAEEPRQP LYVALGYIND QLFLHYDGEN ENSRAELQKP WNDTEEGRKV WERVTQGLEE KGKELRMILQ DILGQNNQSS HTLQATLGCE LQGNDSTRGF WRFRFDGQDF ITFSPEKLSW ISVHPGAQKI KEKWEDWFQM KLQEEEYCSI RLQRYLATWK GILERT // ID F7FTW6_MACMU Unreviewed; 210 AA. AC F7FTW6; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000033207}; GN Name=LOC694076 {ECO:0000313|Ensembl:ENSMMUP00000033207}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000033207, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000033207, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000033207, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000033207} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000033207}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03031932; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9544.ENSMMUP00000033207; -. DR Ensembl; ENSMMUT00000040131; ENSMMUP00000033207; ENSMMUG00000003951. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F7FTW6; -. DR TreeFam; TF341724; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000029466; Expressed in 13 organ(s), highest expression level in colon. DR ExpressionAtlas; F7FTW6; baseline. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}. FT DOMAIN 25 196 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 210 AA; 23615 MW; C70D522341B5BFE0 CRC64; SGAAPTPSPT SRSPLGLLLK ILYPHSLCYD ITIIPKFRPG PRWCAVQGQV DKKTFLPYDC GNKTVTPVSP LGKKLNVTKA WKAQNPVLRE VVDMLTEQLL DIELENYTPR EPLTLQTRMS CEQKAEGHSS GSWQFGFDGQ VFLLFDSENR MWATVHPGAR KMKEKWQNDK DVTMSFRYIS MGDCTKWLKD FLTGTDSTLE PSAGGNNLFP // ID F7FV36_MACMU Unreviewed; 384 AA. AC F7FV36; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000021060}; GN Name=LOC106995876 {ECO:0000313|Ensembl:ENSMMUP00000021060}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000021060, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000021060, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000021060, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000021060} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000021060}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030517; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMMUT00000022512; ENSMMUP00000021060; ENSMMUG00000029875. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000029875; Expressed in 13 organ(s), highest expression level in CD4-positive helper T cell. DR ExpressionAtlas; F7FV36; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 384 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008956951. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 384 AA; 43004 MW; 56D34CE6BD164308 CRC64; MAVMAPRTLL LVLSGVLALT QTQAGSHSMR YFYTAVSRPG RREPLFIAVG YVDDTQFVRF DSDAESPRME PRAPWVEQEG PEYWDRETQN MKTATQTYRG NLRTALRYYN QSEGGSHTIQ KMYGCDLGPD GRLLRGYEQF AYDGRDYIIL NEDLRSWTAA DMAAQFTQRK WEAARAAEQH RTYLEGECLE WLRRYLENGK ETLQRADPPK THVTHHPVSD YEATLRCWAL GFYPAEITLT WQRDGEEQTE DTELVETRPT GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRFEP FSQSTIPIVG IIAGLVLLGT VVTGAVVAAV MWRRKSSGEE GVRSSDSSQG SDVSLTACKG ETLGGLMCGG CWGNSGRSCA VGFL // ID F7G6M0_MONDO Unreviewed; 200 AA. AC F7G6M0; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 12-SEP-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000032790}; GN Name=LOC103094739 {ECO:0000313|Ensembl:ENSMODP00000032790}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000032790, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000032790, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000032790} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR RefSeq; XP_007472664.1; XM_007472602.2. DR RefSeq; XP_007472665.1; XM_007472603.2. DR ProteinModelPortal; F7G6M0; -. DR Ensembl; ENSMODT00000034370; ENSMODP00000032790; ENSMODG00000024063. DR GeneID; 103094739; -. DR KEGG; mdo:103094739; -. DR GeneTree; ENSGT00740000115973; -. DR Proteomes; UP000002280; Chromosome 1. DR Bgee; ENSMODG00000024063; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 200 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003352776. FT DOMAIN 33 197 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 200 AA; 23125 MW; 842392BD06E16B0D CRC64; MMEPLVTAIF LLLLSGTTMS KEPNNLGHSQ CDSLAYRDMA LIYSGAEHDL FTNKAFFNNE LVYKYDSESQ TAKPQPGWEN VENWGEISKL QKERGDFALE NVELIKKTFG YRDDYNLTGI YGCDVCKNNV IKVRWTYYDS DKPLITFDTN GPAWKALSRE GKILKKKWEE DPSAPNRAKS YLEEDCPKKL QEYKNYKNTN // ID F7G7P2_MACMU Unreviewed; 271 AA. AC F7G7P2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000007374}; GN Name=LOC694076 {ECO:0000313|Ensembl:ENSMMUP00000007374}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000007374, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000007374, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000007374, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000007374} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000007374}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03031932; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMMUT00000007847; ENSMMUP00000007374; ENSMMUG00000003951. DR GeneTree; ENSGT00390000003472; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000029466; Expressed in 13 organ(s), highest expression level in colon. DR ExpressionAtlas; F7G7P2; baseline. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}. FT DOMAIN 25 196 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 271 AA; 30296 MW; DD6794C842FAD7C7 CRC64; SGAAPTPSPT SRSPLGLLLK ILYPHSLCYD ITIIPKFRPG PRWCAVQGQV DKKTFLPYDC GNKTVTPVSP LGKKLNVTKA WKAQNPVLRE VVDMLTEQLL DIELENYTPR EPLTLQTRMS CEQKAEGHSS GSWQFGFDGQ VFLLFDSENR MWATVHPGAR KMKEKWQNDK DVTMSFRYIS MGDCTKWLKD FLTGTDSTLE PSAGAPPTVS SGTTQPSAMA TTLILCCLLI MCLLMCPRHS PTHSHGHHPQ SLEPPPHLPL LHPPWLLRRV L // ID F7G7P6_MACMU Unreviewed; 216 AA. AC F7G7P6; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000007373}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000007373, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000007373, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000007373, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000007373} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000007373}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03031933; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMMUT00000007846; ENSMMUP00000007373; ENSMMUG00000029466. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000029466; Expressed in 13 organ(s), highest expression level in colon. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}. FT DOMAIN 46 187 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 216 AA; 24447 MW; 5BFAFF9F84D15831 CRC64; MSTVDGNCSE FSHTDPSDMG TSLNLCSLPL LLALDIQIFY FLLYPHSLCY DITIIPKFRP GPQWYAVQDQ VGKKTFLHYD CGNKTVTPVS PLGKKLNVTK AWKAQNPVLR EVVDMLTEQL LDIQLENYTP REPLTLQARV SCEQKAEGHS SGSWQLSFDG QVFLLFDSEN RMWTTVHPGA RKMKENTLEP SAGGNRRKRN GDLKWVSLEE AQKKAI // ID F7G8H1_MONDO Unreviewed; 355 AA. AC F7G8H1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000013275}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000013275, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000013275, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000013275} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 13616.ENSMODP00000013275; -. DR Ensembl; ENSMODT00000013518; ENSMODP00000013275; ENSMODG00000010596. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7G8H1; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002280; Chromosome 2. DR Bgee; ENSMODG00000010596; Expressed in 7 organ(s), highest expression level in female gonad. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 355 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003352816. FT TRANSMEM 323 347 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 213 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 355 AA; 40283 MW; 11A67172B355B0B9 CRC64; PGTMKPSLLS LFVLGVVALT ETRAGSHSMR YFHTAMSRPE LGDSQFITVG YVDDQQFVRF DSSSESQRME PRAAWMDKMD EEEPNYWEEQ TQIYRKNAQI YRRNLETLRG YYNQSQGGLH TIQRMYGCEV HPDGSFRKGF YQLAYDGRDY IALHRETLTW TAADPGAENT KRKWEAERSI AERYKAYLEE TCLQWLKKYL QMGKDVLLRT DPPSARVSRH SGPDGEVSLR CRAQGFYPAE ISLTWLRDGE EQLQDTEFIE TRPGGDGTFQ KWAAVAMAPG QEDRYSCRVQ HEALAQPLSL RWGTPSSGLS LLFPSSEPEA SSLWVIVGVT AGVLALVTAV VAGAVILRRR NSGRE // ID F7GBN2_ORNAN Unreviewed; 311 AA. AC F7GBN2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000002884}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000002884, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [2] {ECO:0000313|Ensembl:ENSOANP00000002884} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000002884}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7GBN2; -. DR STRING; 9258.ENSOANP00000002884; -. DR Ensembl; ENSOANT00000002885; ENSOANP00000002884; ENSOANG00000001818. DR GeneTree; ENSGT00740000114936; -. DR OMA; CEGETHP; -. DR OrthoDB; EOG091G0BU8; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002279; Unplaced. DR Bgee; ENSOANG00000001818; Expressed in 2 organ(s), highest expression level in testis. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}. FT DOMAIN 202 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 54 74 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 311 AA; 35963 MW; B4700C29CE2F28D7 CRC64; TAIPFFSLFL GGFVALFPTK RELHSLKFFS FAVSEPSPGV PEFGLHVYLD DHFLAQYDSE KQKLKFQNKR IENRVGHGYI EKQILQISLW QDWFQSQMQD IMSHYHHSGA GSHTFQNVIG CEIQKDNSPK GIFFFGYDGE DYISYDLDKE TWTTKDSVAK ITEQKWNATE AHRKSELLDK CVQTFQDLVK YKKYILDLKE RPSGLVTQHT GPNREMILKC WVFSFSSPNI VLSWLKDGEE MEQDTKHSKA RPSGDGTYQK WASVEIPPGE KEKYICRVKH GELSAQFNQA WELEPDSLTI WVIAFCLVAV L // ID F7GBX1_MONDO Unreviewed; 324 AA. AC F7GBX1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000028153}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000028153, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000028153, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000028153} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7GBX1; -. DR Ensembl; ENSMODT00000029733; ENSMODP00000028153; ENSMODG00000023068. DR eggNOG; ENOG410IZF6; Eukaryota. DR eggNOG; ENOG41119ST; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7GBX1; -. DR OrthoDB; EOG091G1FFE; -. DR TreeFam; TF352056; -. DR Proteomes; UP000002280; Chromosome 1. DR Bgee; ENSMODG00000023068; Expressed in 1 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 298 319 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 195 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 324 AA; 37282 MW; 0238476417E3E004 CRC64; ILDPLFSFLP IHSCSAAHHK HMIQFTMVGT GSSLLEYFIV DFLDDVQVFS FNKYNHQLIA KEAWISQVLG AKFIEDTWQK LVDHEKSFLW FLRKLMQNST KSDMNHTVQL FILCEIERNN QLGNEIQIAV NGQDFCWLDE KYGDWFIMVP EAEPFKPILT SNLWTTQRKH YMQEYCIDTM KKILQHSSIK KNVPPEVTVS YHEAMDGITT LSCSATGFYP SSILLHWQKK EKKIVVGKES SSGLLPNADS TFYQRVFIEL PPEETGTNYD CVVEHIELGT PKVYPAHVKS SKKRSRTLTL AILGVVILVL SSIASFIMWH KIKT // ID F7GIY0_MONDO Unreviewed; 364 AA. AC F7GIY0; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000004814}; GN Name=MODO-UC {ECO:0000313|Ensembl:ENSMODP00000004814}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000004814, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000004814, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000004814} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 13616.ENSMODP00000004814; -. DR Ensembl; ENSMODT00000004917; ENSMODP00000004814; ENSMODG00000003927. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7GIY0; -. DR OMA; SALTKTW; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002280; Chromosome 2. DR Bgee; ENSMODG00000003927; Expressed in 8 organ(s), highest expression level in female gonad. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003353002. FT TRANSMEM 306 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 40867 MW; 90F5C99F55111DB6 CRC64; MELSLLSLFV LGVVALTETR AGSHSMRYFH TAMSRPELGD SQFITVGYVD DQQFVRFDSS SESQRMEPRA AWMDKMDEEE PNYWEEQTQI YRKNAQIYRG NLETLRGYYN QSHGGLHTIQ RMIGCEVSPE GSFRKGFYQF AYDGHDYIAL HSETLSWTAA DTGAENTKRK WEPEKSIAES YKAYLEKECT HWLKKYLEMG KDVLLRTDPP SVRVTRYSGP DGEVSLRCRA HGFYPAEISL TWLRDGEEQL QDTEFIETRP GGDGTFQKWA AVAMAPGQED RYSCRVQHEA LAQPLSLRWE PEASSVWVIV GVTAGVLVLV TAVVAGAVIL RRRNSGGKGG VYVPAADKDS AQGSDVSLTA TGEA // ID F7GIY9_MACMU Unreviewed; 352 AA. AC F7GIY9; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 47. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSMMUP00000026328}; GN Name=MR1 {ECO:0000313|Ensembl:ENSMMUP00000026328}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000026328, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000026328, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000026328, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000026328} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000026328}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03003292; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03003293; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9544.ENSMMUP00000026328; -. DR Ensembl; ENSMMUT00000028141; ENSMMUP00000026328; ENSMMUG00000020023. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7GIY9; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Chromosome 1. DR Bgee; ENSMMUG00000020023; Expressed in 15 organ(s), highest expression level in lung. DR ExpressionAtlas; F7GIY9; baseline. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 352 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008957070. FT DOMAIN 199 277 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 352 AA; 40847 MW; 8A6EBF71E690C55C CRC64; MVFLLPLVVV VMVKHSDSRT HSLRYFRLGI SDPGHGVPEF ISVGYVDSQP ITTYDSVTRQ KEPRAPWMAE NLAPDHWERY TQLLRGWQQT FKVELKRLQR HYNHSGSHTY QRMIGCELLE DGSTTGFLQY AYDGQDFLIF NKDSLSWLAV DNVAHTVKRA WEANQHELRY QKNWLEKECI AWLKRFLEYG NDTLQRTEPP LVRVNRKETF PGVTTLFCKA YSFYPPEIYM TWMKNGEEIV QEMDYGDILP SGDGTYQTWA SVELDPKSSN LYSCHVEIRN HPSCNESCLW VHYPCHCAGW SWCSSLEKKA PRAKWSHVPS DTRSMIADPS FPVLLPVGAM FSSVPHRLKR SA // ID F7GIZ3_MACMU Unreviewed; 339 AA. AC F7GIZ3; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 37. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSMMUP00000026327}; GN Name=MR1 {ECO:0000313|Ensembl:ENSMMUP00000026327}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000026327, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000026327, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000026327, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000026327} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000026327}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03003292; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03003293; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMMUT00000028140; ENSMMUP00000026327; ENSMMUG00000020023. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000006718; Chromosome 1. DR Bgee; ENSMMUG00000020023; Expressed in 15 organ(s), highest expression level in lung. DR ExpressionAtlas; F7GIZ3; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 298 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 201 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 339 AA; 39167 MW; 2DCB367B0F7A31F7 CRC64; MQMKDLDSLG PYMSSFFASF PGTHSLRYFL GVSDPGHGVP EFISVGYVDS QPITTYDSVT WQKEPRAPWM AENLAPDHWE RYTQLLRGWQ QTFKVELKRL QRHYNHSGSH TYQRMIGCEL LEDGSTTGFL QYAYDGQDFL IFNKDSLSWL AVDNVAHTVK RAWEANQHEL RYQKNWLEKE CIAWLKRFLE YGNDTLQRTE PPLVRVNRKE TFPGVTTLFC KAYSFYPPEI YMTWMKNGEE IVQEMDYGDI LPSGDGTYQT WASVELDPKS SNLYSCHVEH CGVHMVLQVP QESETIPLVM KAVSGSIILV IVLAGVGVLV WRRRPREQNG AMYLPTPDR // ID F7GQK4_MACMU Unreviewed; 365 AA. AC F7GQK4; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000026141}; GN Name=LOC715737 {ECO:0000313|Ensembl:ENSMMUP00000026141}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000026141, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000026141, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000026141, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000026141} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000026141}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030526; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030527; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9544.ENSMMUP00000026141; -. DR Ensembl; ENSMMUT00000027943; ENSMMUP00000026141; ENSMMUG00000019888. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7GQK4; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000019888; Expressed in 13 organ(s), highest expression level in peripheral blood mononuclear cell. DR ExpressionAtlas; F7GQK4; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008957134. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 40741 MW; 4715B2B76D102C36 CRC64; MAIMAPRTLL LVLSGALALT QTRAGSHSMR YFYTSMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWVEQEG PEYWDRETQN MKTATQNAPV ALRNLRGYYN QSEVGSHTFQ RMVGCDLGPD GRLLRGYEQY AYDGRDYIAL NEDLRSWTAA DMAAQNTQRK WEAADVAERM RAYLEGECVE WLPRYLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGKEQR YTCHVQHEGL PKPLTLKWEP SSQSTIPIVG IIAGLVLLGA VVTGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDVSL TACKV // ID F7GRH8_CALJA Unreviewed; 348 AA. AC F7GRH8; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 54. DE SubName: Full=Hereditary hemochromatosis protein isoform 1 {ECO:0000313|EMBL:JAB04563.1}; GN Name=HFE {ECO:0000313|EMBL:JAB04563.1}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB04563.1}; RN [1] {ECO:0000313|EMBL:JAB04563.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Bladder {ECO:0000313|EMBL:JAB04563.1}; RX PubMed=25243066; DOI=10.1186/2047-217X-3-14; RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C., RA Moriyama E.N., French J.A., Norgren R.B.Jr.; RT "De novo assembly of the common marmoset transcriptome from NextGen RT mRNA sequences."; RL Gigascience 3:14-14(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; GAMT01007298; JAB04563.1; -; mRNA. DR RefSeq; XP_002746173.1; XM_002746127.3. DR STRING; 9483.ENSCJAP00000044307; -. DR GeneID; 100390471; -. DR KEGG; cjc:100390471; -. DR CTD; 3077; -. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. SQ SEQUENCE 348 AA; 39787 MW; 823E339016A94350 CRC64; MSPRARPALL LLMLLQTAVP QGRLLRSHSL HYLFMGASEQ DLGLSLFEAL GYVDDQLFVF YDHESRRVEP RTPWVSSRTS SQMWLQLSQS LKGWDHMFTV DFWTIMDNHN HSKESHTLQV ILGCEMQEDN STKGFWKYGY DGQDHLEFCS DTLDWRAAEP RAWPTKLEWE AHKIRARQNR AYLERDCPAQ LQQLLELGRG VLDQQVRPLV KVTHHVTSSV TTLRCRALNF YPRNITMKWL KDRQPLNAEE AEPKDVLPNG DGTYQGWIAL AVPAGEEQRY TCQVEHPGLD QPLLAIWEPS HSGTLIAAVV TGIAVCVIIL LIGILFIILR KRQASRGAVG QYVLAECE // ID F7HAR1_MACMU Unreviewed; 337 AA. AC F7HAR1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 59. DE SubName: Full=Hereditary hemochromatosis protein precursor {ECO:0000313|Ensembl:ENSMMUP00000031265}; GN Name=HFE {ECO:0000313|Ensembl:ENSMMUP00000031265}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000031265, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000031265, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000031265, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000031265} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000031265}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030466; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9544.ENSMMUP00000031265; -. DR Ensembl; ENSMMUT00000033407; ENSMMUP00000031265; ENSMMUG00000023733. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000023733; Expressed in 14 organ(s), highest expression level in liver. DR ExpressionAtlas; F7HAR1; baseline. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IBA:GO_Central. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 337 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008957406. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 337 AA; 39051 MW; 4F899FE56C30D0D0 CRC64; MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGSSEQ DLGLSLFEAL GYVDDQLFVF YDHESRRVEP RTPWVSGRTS SQMWLQLSQS LKGWDHMFTV DFWTIMENHN HSKESHTLQV ILGCKMQEDN STEGFWKYGY DGQDHLEFCP DTLDWRAAEP RAWPTKLEWE RHKIRARQNR AYLERDCPVQ LQQLLELGRG VFDRPVPPLV KVTHHVTSSV TTLRCRALNY YPQNITMKWL KDRQSMDAKE VEPKDVLPNG DGTYQGWITL TVPPGEEQRY TCQVEHPGLD QPLLAFWEPS PSRTLVIGVI SGIAVFVIIL FIGILFIILR KRQTSSF // ID F7HAS2_MACMU Unreviewed; 242 AA. AC F7HAS2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 54. DE SubName: Full=Hereditary hemochromatosis protein precursor {ECO:0000313|Ensembl:ENSMMUP00000031259}; GN Name=HFE {ECO:0000313|Ensembl:ENSMMUP00000031259}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000031259, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000031259, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000031259, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000031259} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000031259}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030466; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMMUT00000033401; ENSMMUP00000031259; ENSMMUG00000023733. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000023733; Expressed in 14 organ(s), highest expression level in liver. DR ExpressionAtlas; F7HAS2; baseline. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 242 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008957412. FT TRANSMEM 199 223 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 112 180 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 242 AA; 27876 MW; 17A3526D0A4737CA CRC64; MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGSSEQ DLGLSLFEAL GYVDDQLFVF YDHESRRVEP RTPWVSGRTS SQMWLQLSQS LKGWDHMFTV DFWTIMENHN HSKVTTLRCR ALNYYPQNIT MKWLKDRQSM DAKEVEPKDV LPNGDGTYQG WITLTVPPGE EQRYTCQVEH PGLDQPLLAF WEPSPSRTLV IGVISGIAVF VIILFIGILF IILRKRQTSR GVMGHYVLAE RE // ID F7HAS4_MACMU Unreviewed; 260 AA. AC F7HAS4; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 49. DE SubName: Full=Hereditary hemochromatosis protein precursor {ECO:0000313|Ensembl:ENSMMUP00000031258}; GN Name=HFE {ECO:0000313|Ensembl:ENSMMUP00000031258}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000031258, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000031258, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000031258, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000031258} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000031258}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030466; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F7HAS4; -. DR Ensembl; ENSMMUT00000033400; ENSMMUP00000031258; ENSMMUG00000023733. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000023733; Expressed in 14 organ(s), highest expression level in liver. DR ExpressionAtlas; F7HAS4; baseline. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 260 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003353816. FT TRANSMEM 217 241 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 119 198 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 260 AA; 29867 MW; A721B8ADEE727D94 CRC64; MGPRARPALL LLMLLQTAVL QGRLLQSHTL QVILGCKMQE DNSTEGFWKY GYDGQDHLEF CPDTLDWRAA EPRAWPTKLE WERHKIRARQ NRAYLERDCP VQLQQLLELG RGVFDRPVPP LVKVTHHVTS SVTTLRCRAL NYYPQNITMK WLKDRQSMDA KEVEPKDVLP NGDGTYQGWI TLTVPPGEEQ RYTCQVEHPG LDQPLLAFWE PSPSRTLVIG VISGIAVFVI ILFIGILFII LRKRQTSRGV MGHYVLAERE // ID F7HME9_MACMU Unreviewed; 386 AA. AC F7HME9; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-SEP-2018, entry version 39. DE SubName: Full=MHC class I polypeptide-related sequence B precursor {ECO:0000313|Ensembl:ENSMMUP00000008686}; GN Name=MICB {ECO:0000313|Ensembl:ENSMMUP00000008686}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000008686, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000008686, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000008686, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000008686} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000008686}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030619; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030620; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030621; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030622; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030623; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030624; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030625; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030626; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030627; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F7HME9; -. DR STRING; 9544.ENSMMUP00000008686; -. DR Ensembl; ENSMMUT00000009245; ENSMMUP00000008686; ENSMMUG00000006609. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7HME9; -. DR OMA; CVPCCKK; -. DR OrthoDB; EOG091G0ANY; -. DR TreeFam; TF342166; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000006609; Expressed in 13 organ(s), highest expression level in CD4-positive helper T cell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 386 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003354488. FT TRANSMEM 310 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 89 109 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 386 AA; 43276 MW; 13DDD93EC69818DD CRC64; MGLGRVLLFL GRVLLFLASI FSFTRPGAAA ELHSLRYNVT VLSRDGSVQS EFLAEGHLDG QLFVRYDRET RRARPQGQWA EAVLGDQETE DLTENAQDLR RTLTHIEGQK GGLHSLQKIK ICEIYEDGST GGFWHFYYDG ELFLSLNLET QKWTVAQSSR AQTLAMNFWK EDTMKTNTHY RAMRADCLKK LRRYQKSRVA VRRTVPPMVN VTHGEASEGN ITVTCRASGF YPGNITLTWR QDGVSLSHDA QQWGDVLPDW NGTYQTWVAT RIRQGEEQRF ACYMEHSRNH STHPVPSGKP PVLQSERLNL LYVPVAVAVA VVTAFIIICV HRCKKKKTSA AEGPELVSLR TLDQHPVGTG DHRDATQLGF QPLMSAPGST GSTEGA // ID F7I529_CALJA Unreviewed; 246 AA. AC F7I529; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000040105}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000040105, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000040105, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000040105} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7I529; -. DR STRING; 9483.ENSCJAP00000040105; -. DR Ensembl; ENSCJAT00000042363; ENSCJAP00000040105; ENSCJAG00000036082. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; F7I529; -. DR OMA; CKMWLEE; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000008225; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 246 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015311415. FT DOMAIN 31 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 246 AA; 27921 MW; 8BE7D3520900D02A CRC64; MAAAASPAWL QCLPLLLQLS GWSRAERADP HSLCYDVTIT PKFRPGPWWC VVQGQLDQKT FLHYDCGNKT VTPVSLLGKK INATKSWKEQ NPVLRELVDM LTEQLLGIQL QNYTPREPLT LQARMSCEQK AEGHSSGSWQ FSFDGQIFLL FDSENRMWTT VHPGARKMKE KWENDKDMTM SFYYFSTGDC TRWLEDFLMG MDRTLEPSEG APPTMAPGTA QPKATATTLS PWSLFIILFC FILPGI // ID F7IBZ4_CALJA Unreviewed; 499 AA. AC F7IBZ4; F7I925; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000005965}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000005965, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000005965, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000005965} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7IBZ4; -. DR STRING; 9483.ENSCJAP00000005965; -. DR Ensembl; ENSCJAT00000003027; ENSCJAP00000002864; ENSCJAG00000043365. DR Ensembl; ENSCJAT00000006287; ENSCJAP00000005965; ENSCJAG00000043365. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7IBZ4; -. DR OMA; LENECIE; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 499 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015290453. FT TRANSMEM 440 464 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 343 431 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 499 AA; 55824 MW; 53D34961C3E1AFB3 CRC64; MKSEGRGTGP MLRVSLWFLS SSWAKTQGDI DTERLAQEER GQGEVPGPRY GSQGLRTRRR CMDWEAQRWG FPISAVSLPL PTCVRSFFLD THDANPVLTP IGCRVSREAN QLPAVPVLKS PVTHPDSDYP QMLRMTVMAP RTLLLLLSGT LALTQTRAGS HSLRYFHISV SRPGRGEPRF ITVGYVDDTQ FVRFDSDAAS PRKEPRAPWM EQEGPEYWDR ETLISKQNAQ TYRVNLRTLR GYYNQTEAGS HTIQRMYGCD VGPDGRLLRG YNQDAYDGKD YIALNEDLRS WTAADVAAQI TQRKWEAANE AERMRAYLEG TCVEWLRRYL ENGKETLQRA VPPKTHVTHH PVSDDEATLR CWTLGFYPAE ITLTWQRDGE DQTQDMELVE TRPTGDGNFQ KWAAVVVPSG EEQRYTCHVQ HEGLPEPLTL RWEPPSQPTI PIVGIIAGLV AFGAVVTGAV VAAVMCRKKS SDKKGGSYSQ AASSDSAQGS DVSLTACKV // ID F7IE31_CALJA Unreviewed; 498 AA. AC F7IE31; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 12-SEP-2018, entry version 48. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000038306}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000038306, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000038306, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000038306} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7IE31; -. DR Ensembl; ENSCJAT00000040473; ENSCJAP00000038306; ENSCJAG00000043365. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR OMA; QPRFIAV; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 498 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015316237. FT TRANSMEM 440 465 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 343 431 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 498 AA; 55985 MW; D8276B250FD6699F CRC64; MKSEGRGTGP MLRVSLWFLS SSWAKTQGDI DTERLAQEER GQGEVPGPRY GSQGLRTRRR CMDWEAQRWG FPISAVSLPL PTCVRSFFLD THDANPVLTP IGCRVSREAN QLPAVPVLKS PVTHPDSDYP QMLRMTVMAP RTLLLLLSGT LALTQTRAGS HSLRYFHISV SRPGRGEPRF ITVGYVDDTQ FVRFDSDAAS PRKEPRAPWM EQEGPEYWDR ETLISKQNAQ TYRVNLRTLR GYYNQTEAGS HTIQWMSGCD VGPDGRLLRG YRQDAYDGKD YIALNEDLRS WTAADVAAQI TQRKWEAANV AERRRAYLEG TCVEWLRRYL ENGKETLQRA EPPKTHVTHH PVSDHEATLR CWALGFYPAE ITLTWQRDGE DQTQDMELIE TRPAGDRTFQ KWAAVVVLSG EEHRYTCHVQ HEGLPEPLTL RWEPSSQPTI PIMGIVAALA ILGALAGAVV AAVMWRKKSS DKKGGSYSQA ARSESAQGSD VSLTACKV // ID F7IRA0_CALJA Unreviewed; 311 AA. AC F7IRA0; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 12-SEP-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000005898}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000005898, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000005898, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000005898} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9483.ENSCJAP00000005898; -. DR Ensembl; ENSCJAT00000006212; ENSCJAP00000005898; ENSCJAG00000003232. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F7IRA0; -. DR OMA; CVPCCKK; -. DR OrthoDB; EOG091G0HEI; -. DR TreeFam; TF342166; -. DR Proteomes; UP000008225; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 311 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015306575. FT DOMAIN 202 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 79 106 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 311 AA; 34365 MW; 947333C723809EBF CRC64; MRLGPVLLLL AGVFSFAAPG AAAEPHSLRY NLTVLSWDGS VQSGFLADGH LDGQLFLLCD RQKCPAGPQG QWAEAILRAE TSNTEIEDLR ENEKDLKMTL AHEKGQKGAL HSLQEIRLCE IHEDGSTRGF RHFYSDGELF LSQNLDTREW NVSQSSRVQI LPINITKVLE ENAKKAGTVL ADCLWKLRRY LASGAGIRRT VPPMVNVTRS EGSERNINVT CWASGFYPPN ITLNWCQDGV SLSHDAQHSE GVLPDGNGTY QTWVTIRIRQ GEEQRFTCYM EHSGNHSTHP VPSGEPGVTL ERVSCGSLPG V // ID F7IT79_CALJA Unreviewed; 368 AA. AC F7IT79; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000026469}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000026469, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000026469, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000026469} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7IT79; -. DR Ensembl; ENSCJAT00000027980; ENSCJAP00000026469; ENSCJAG00000035381. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; F7IT79; -. DR OMA; VHEIHER; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 368 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015330883. FT TRANSMEM 283 308 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 274 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 41125 MW; 4C1E81226B80E687 CRC64; MAPRILLLLL SGALVLTKTW AGSHYMRYFC TAVSWPGRGE PRFISAGYVD DTQFVRFDSD AASGRGEPRA PWMEQEGPEY WDRETLTLRA SAQTHRGNLR TLRGYYNQSE AGSHTLQTTY GCDLGPDGRL FRGYYQHAYD DKDYIALNED LRSWTAADTA AQITQRKAYL EGTCLKWLRR YLAKGKETAT HVTHHPVSDH EATLRCWALG FYPVEITLTW QKDGEDQTQD AELVETRPAG DGTFQKWTAV VVPSGEEQGY MCHVQHKGLP KPLTLRWEPS SQLTIPIVGI VADLVFFGAV VIGAVVTAMM WRRKSSGRET VRGGVWVFLS HSGFQAPGRS VPCLISGKHH PHMGQPSLGP CLPVLTVL // ID F8VQG4_MOUSE Unreviewed; 363 AA. AC F8VQG4; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 12-SEP-2018, entry version 64. DE SubName: Full=Histocompatibility 2, T region locus 24 {ECO:0000313|Ensembl:ENSMUSP00000109389}; GN Name=H2-T24 {ECO:0000313|Ensembl:ENSMUSP00000109389, GN ECO:0000313|MGI:MGI:95958}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000109389, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000109389, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000109389, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000109389} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000109389}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC112970; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_032233.2; NM_008207.3. DR RefSeq; XP_011244608.1; XM_011246306.2. DR UniGene; Mm.439654; -. DR ProteinModelPortal; F8VQG4; -. DR STRING; 10090.ENSMUSP00000109389; -. DR MaxQB; F8VQG4; -. DR PaxDb; F8VQG4; -. DR PRIDE; F8VQG4; -. DR DNASU; 15042; -. DR Ensembl; ENSMUST00000113760; ENSMUSP00000109389; ENSMUSG00000053835. DR GeneID; 15042; -. DR KEGG; mmu:15042; -. DR UCSC; uc008cjq.1; mouse. DR CTD; 15042; -. DR MGI; MGI:95958; H2-T24. DR eggNOG; ENOG410J90V; Eukaryota. DR eggNOG; ENOG41117CA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; F8VQG4; -. DR KO; K06751; -. DR OMA; TSRMKIF; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000053835; Expressed in 141 organ(s), highest expression level in blood. DR ExpressionAtlas; F8VQG4; baseline and differential. DR Genevisible; F8VQG4; MM. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:F8VQG4, KW ECO:0000213|MaxQB:F8VQG4}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 363 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003379460. FT TRANSMEM 321 340 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 363 AA; 41947 MW; 7CF7383CC114AE10 CRC64; MWALIFWLLS HPQDGGARSH SLHYCYSAVT EPGPGVPSFF ASGFLDNQPF IHYDSRSMKA EPCADWLREN AQYFTHETEV FTNRMKIFQL SLRNIRQYYN SSGTQSQRAD GFRQQAGPHT LQFTYGCEMR YNRTTGHWQY GYDGSDYLTL DLGSMQYIAA TFIAGYTKRK WENNEYWLEK EKTYLEKECI LWLQRYLTMG GKNFTRTDPP KTTVTHQFKP KENVTLRCWA LGFYPADITL TWQLNGEELT QDTELVETRP SGDGTFQKWA AVVVPSGEEQ RYTCHVQHEA LTQPLVLKWE PLQLTTPTTG VYARGSCSPQ ATLLSVLAFP LFGIVLVFGL TRYKTQVRRK NWPAPSVPEE ERL // ID F8W7W8_HUMAN Unreviewed; 337 AA. AC F8W7W8; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 12-SEP-2018, entry version 59. DE SubName: Full=Hereditary hemochromatosis protein {ECO:0000313|Ensembl:ENSP00000311698}; GN Name=HFE {ECO:0000313|Ensembl:ENSP00000311698}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000311698, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000311698, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000311698} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; U91328; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001287678.1; NM_001300749.1. DR UniGene; Hs.233325; -. DR ProteinModelPortal; F8W7W8; -. DR MaxQB; F8W7W8; -. DR PeptideAtlas; F8W7W8; -. DR PRIDE; F8W7W8; -. DR Ensembl; ENST00000309234; ENSP00000311698; ENSG00000010704. DR GeneID; 3077; -. DR UCSC; uc063mge.1; human. DR CTD; 3077; -. DR EuPathDB; HostDB:ENSG00000010704.18; -. DR HGNC; HGNC:4886; HFE. DR OpenTargets; ENSG00000010704; -. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR GenomeRNAi; 3077; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000010704; Expressed in 196 organ(s), highest expression level in mononuclear cell. DR ExpressionAtlas; F8W7W8; baseline and differential. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:F8W7W8, KW ECO:0000213|PeptideAtlas:F8W7W8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 337 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003379636. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 337 AA; 38872 MW; 8D508D559EBC8048 CRC64; MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGASEQ DLGLSLFEAL GYVDDQLFVF YDHESRRVEP RTPWVSSRIS SQMWLQLSQS LKGWDHMFTV DFWTIMENHN HSKESHTLQV ILGCEMQEDN STEGYWKYGY DGQDHLEFCP DTLDWRAAEP RAWPTKLEWE RHKIRARQNR AYLERDCPAQ LQQLLELGRG VLDQQVPPLV KVTHHVTSSV TTLRCRALNY YPQNITMKWL KDKQPMDAKE FEPKDVLPNG DGTYQGWITL AVPPGEEQRY TCQVEHPGLD QPLIVIWEPS PSGTLVIGVI SGIAVFVVIL FIGILFIILR KRQGSSF // ID F8W9Z8_HUMAN Unreviewed; 131 AA. AC F8W9Z8; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 12-SEP-2018, entry version 48. DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000365412}; GN Name=HLA-C {ECO:0000313|Ensembl:ENSP00000365412}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000365412, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000365412, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000365412} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL671883; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F8W9Z8; -. DR MaxQB; F8W9Z8; -. DR PeptideAtlas; F8W9Z8; -. DR PRIDE; F8W9Z8; -. DR Ensembl; ENST00000376237; ENSP00000365412; ENSG00000204525. DR UCSC; uc063mzw.1; human. DR EuPathDB; HostDB:ENSG00000204525.15; -. DR HGNC; HGNC:4933; HLA-C. DR OpenTargets; ENSG00000204525; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR ChiTaRS; HLA-C; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204525; Expressed in 234 organ(s), highest expression level in mononuclear cell. DR ExpressionAtlas; F8W9Z8; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:F8W9Z8, KW ECO:0000213|MaxQB:F8W9Z8, ECO:0000213|PeptideAtlas:F8W9Z8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 131 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003385452. FT DOMAIN 26 115 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 131 AA; 15088 MW; 048B8BAEBCE8C7C2 CRC64; MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV SLRNLRGYYN QSEDEDVWLR PGARRAPPPR V // ID FCGRN_HUMAN Reviewed; 365 AA. AC P55899; Q5HYM5; Q9HBV7; Q9NZ19; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 12-SEP-2018, entry version 161. DE RecName: Full=IgG receptor FcRn large subunit p51; DE Short=FcRn; DE AltName: Full=IgG Fc fragment receptor transporter alpha chain; DE AltName: Full=Neonatal Fc receptor; DE Flags: Precursor; GN Name=FCGRT; Synonyms=FCRN; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY. RC TISSUE=Placenta; RX PubMed=7964511; DOI=10.1084/jem.180.6.2377; RA Story C.M., Mikulska J., Simister N.E.; RT "A major histocompatibility complex class I-like Fc receptor cloned RT from human placenta: possible role in transfer of immunoglobulin G RT from mother to fetus."; RL J. Exp. Med. 180:2377-2381(1994). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Tiwari B., Junghans R.P.; RT "Partial sequence of the human fcgrt gene and its 5' upstream RT region."; RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=10998088; DOI=10.1046/j.1365-2370.2000.00225.x; RA Mikulska J.E., Pablo L., Canel J., Simister N.E.; RT "Cloning and analysis of the gene encoding the human neonatal Fc RT receptor."; RL Eur. J. Immunogenet. 27:231-240(2000). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Rectum tumor; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP PROTEIN SEQUENCE OF 24-38. RX PubMed=15340161; DOI=10.1110/ps.04682504; RA Zhang Z., Henzel W.J.; RT "Signal peptide prediction based on analysis of experimentally RT verified cleavage sites."; RL Protein Sci. 13:2819-2824(2004). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [10] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [11] {ECO:0000244|PDB:1EXU} RP X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 24-290, FUNCTION, AND RP DISULFIDE BONDS. RX PubMed=10933786; DOI=10.1021/bi000749m; RA West A.P. Jr., Bjorkman P.J.; RT "Crystal structure and immunoglobulin G binding properties of the RT human major histocompatibility complex-related Fc receptor."; RL Biochemistry 39:9698-9708(2000). CC -!- FUNCTION: Binds to the Fc region of monomeric immunoglobulins CC gamma (PubMed:7964511, PubMed:10933786). Mediates the selective CC uptake of IgG from milk and helps newborn animals to acquire CC passive immunity. IgG in the milk is bound at the apical surface CC of the intestinal epithelium. The resultant FcRn-IgG complexes are CC transcytosed across the intestinal epithelium and IgG is released CC from FcRn into blood or tissue fluids (By similarity). Possible CC role in transfer of immunoglobulin G from mother to fetus CC (PubMed:7964511). {ECO:0000250|UniProtKB:P13599, CC ECO:0000269|PubMed:10933786, ECO:0000269|PubMed:7964511}. CC -!- SUBUNIT: FcRn complex consist of two subunits: p51, and p14 which CC is equivalent to beta-2-microglobulin. It forms an MHC class I- CC like heterodimer. {ECO:0000250|UniProtKB:P13599}. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000250|UniProtKB:P13599}; Single-pass type I membrane CC protein {ECO:0000255}. CC -!- TISSUE SPECIFICITY: Expressed in full-term placenta, heart, lung, CC liver, muscle, kidney, pancreas, and both fetal and adult small CC intestine. {ECO:0000269|PubMed:7964511}. CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; U12255; AAA58958.1; -; mRNA. DR EMBL; AF220542; AAF72596.1; -; Genomic_DNA. DR EMBL; AF200220; AAG31421.1; -; Genomic_DNA. DR EMBL; AF200219; AAG31421.1; JOINED; Genomic_DNA. DR EMBL; BX647163; CAI46032.1; -; mRNA. DR EMBL; CH471177; EAW52498.1; -; Genomic_DNA. DR EMBL; BC008734; AAH08734.1; -; mRNA. DR CCDS; CCDS12770.1; -. DR PIR; I38720; I38720. DR RefSeq; NP_001129491.1; NM_001136019.2. DR RefSeq; NP_004098.1; NM_004107.4. DR UniGene; Hs.111903; -. DR PDB; 1EXU; X-ray; 2.70 A; A=24-290. DR PDB; 3M17; X-ray; 2.60 A; A/C/E/G=24-290. DR PDB; 3M1B; X-ray; 3.10 A; A/C/E/G=24-290. DR PDB; 4K71; X-ray; 2.40 A; B/E=24-297. DR PDB; 4N0F; X-ray; 3.02 A; A/E/H/K=27-297. DR PDB; 4N0U; X-ray; 3.80 A; A=27-290. DR PDB; 5BJT; X-ray; 3.20 A; A/C/E/G=24-290. DR PDB; 5BXF; X-ray; 2.85 A; A/C=1-290. DR PDB; 5WHK; X-ray; 2.50 A; A=1-297. DR PDB; 6C97; X-ray; 2.00 A; A/C=24-297. DR PDB; 6C98; X-ray; 1.85 A; A/C=24-297. DR PDB; 6C99; X-ray; 2.00 A; A/C=24-297. DR PDBsum; 1EXU; -. DR PDBsum; 3M17; -. DR PDBsum; 3M1B; -. DR PDBsum; 4K71; -. DR PDBsum; 4N0F; -. DR PDBsum; 4N0U; -. DR PDBsum; 5BJT; -. DR PDBsum; 5BXF; -. DR PDBsum; 5WHK; -. DR PDBsum; 6C97; -. DR PDBsum; 6C98; -. DR PDBsum; 6C99; -. DR ProteinModelPortal; P55899; -. DR SMR; P55899; -. DR BioGrid; 108511; 64. DR DIP; DIP-6165N; -. DR IntAct; P55899; 9. DR MINT; P55899; -. DR STRING; 9606.ENSP00000221466; -. DR BindingDB; P55899; -. DR ChEMBL; CHEMBL5966; -. DR GuidetoPHARMACOLOGY; 2985; -. DR iPTMnet; P55899; -. DR PhosphoSitePlus; P55899; -. DR BioMuta; FCGRT; -. DR DMDM; 2497331; -. DR EPD; P55899; -. DR MaxQB; P55899; -. DR PaxDb; P55899; -. DR PeptideAtlas; P55899; -. DR PRIDE; P55899; -. DR ProteomicsDB; 56878; -. DR DNASU; 2217; -. DR Ensembl; ENST00000221466; ENSP00000221466; ENSG00000104870. DR Ensembl; ENST00000426395; ENSP00000410798; ENSG00000104870. DR GeneID; 2217; -. DR KEGG; hsa:2217; -. DR UCSC; uc002poe.3; human. DR CTD; 2217; -. DR DisGeNET; 2217; -. DR EuPathDB; HostDB:ENSG00000104870.12; -. DR GeneCards; FCGRT; -. DR HGNC; HGNC:3621; FCGRT. DR HPA; HPA012122; -. DR HPA; HPA015130; -. DR MIM; 601437; gene. DR neXtProt; NX_P55899; -. DR OpenTargets; ENSG00000104870; -. DR PharmGKB; PA28067; -. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000112560; -. DR HOVERGEN; HBG100415; -. DR InParanoid; P55899; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR PhylomeDB; P55899; -. DR TreeFam; TF336617; -. DR ChiTaRS; FCGRT; human. DR EvolutionaryTrace; P55899; -. DR GeneWiki; FCGRT; -. DR GenomeRNAi; 2217; -. DR PRO; PR:P55899; -. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000104870; Expressed in 208 organ(s), highest expression level in mucosa of transverse colon. DR CleanEx; HS_FCGRT; -. DR ExpressionAtlas; P55899; baseline and differential. DR Genevisible; P55899; HS. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; IBA:GO_Central. DR GO; GO:0019864; F:IgG binding; IDA:UniProtKB. DR GO; GO:0019770; F:IgG receptor activity; IBA:GO_Central. DR GO; GO:0002416; P:IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor; NAS:UniProtKB. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Cell membrane; Complete proteome; KW Direct protein sequencing; Disulfide bond; Glycoprotein; KW IgG-binding protein; Immunoglobulin domain; Membrane; Phosphoprotein; KW Receptor; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 23 {ECO:0000269|PubMed:15340161}. FT CHAIN 24 365 IgG receptor FcRn large subunit p51. FT {ECO:0000269|PubMed:15340161}. FT /FTId=PRO_0000015157. FT TOPO_DOM 24 297 Extracellular. {ECO:0000255}. FT TRANSMEM 298 321 Helical. {ECO:0000255}. FT TOPO_DOM 322 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 202 289 Ig-like C1-type. {ECO:0000255|PROSITE- FT ProRule:PRU00114}. FT REGION 24 110 Alpha-1. {ECO:0000244|PDB:1EXU, FT ECO:0000269|PubMed:10933786}. FT REGION 111 200 Alpha-2. {ECO:0000244|PDB:1EXU, FT ECO:0000269|PubMed:10933786}. FT REGION 201 290 Alpha-3. {ECO:0000244|PDB:1EXU, FT ECO:0000269|PubMed:10933786}. FT REGION 291 297 Connecting peptide. FT MOD_RES 334 334 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT CARBOHYD 125 125 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 119 182 {ECO:0000244|PDB:1EXU, FT ECO:0000269|PubMed:10933786}. FT DISULFID 221 275 {ECO:0000244|PDB:1EXU, FT ECO:0000269|PubMed:10933786}. FT CONFLICT 101 103 Missing (in Ref. 3; AAG31421). FT {ECO:0000305}. FT CONFLICT 201 201 E -> G (in Ref. 2; AAF72596). FT {ECO:0000305}. FT STRAND 29 39 {ECO:0000244|PDB:6C98}. FT STRAND 46 53 {ECO:0000244|PDB:6C98}. FT STRAND 56 62 {ECO:0000244|PDB:6C98}. FT TURN 63 65 {ECO:0000244|PDB:6C98}. FT HELIX 72 76 {ECO:0000244|PDB:6C98}. FT HELIX 83 104 {ECO:0000244|PDB:6C98}. FT STRAND 107 109 {ECO:0000244|PDB:4N0F}. FT STRAND 112 121 {ECO:0000244|PDB:6C98}. FT HELIX 123 125 {ECO:0000244|PDB:6C98}. FT STRAND 127 135 {ECO:0000244|PDB:6C98}. FT STRAND 138 144 {ECO:0000244|PDB:6C98}. FT TURN 145 148 {ECO:0000244|PDB:6C98}. FT STRAND 149 151 {ECO:0000244|PDB:6C98}. FT HELIX 155 166 {ECO:0000244|PDB:6C98}. FT HELIX 170 179 {ECO:0000244|PDB:6C98}. FT HELIX 181 192 {ECO:0000244|PDB:6C98}. FT HELIX 194 197 {ECO:0000244|PDB:6C98}. FT STRAND 204 211 {ECO:0000244|PDB:6C98}. FT STRAND 213 215 {ECO:0000244|PDB:3M1B}. FT STRAND 216 229 {ECO:0000244|PDB:6C98}. FT STRAND 231 237 {ECO:0000244|PDB:6C98}. FT STRAND 240 243 {ECO:0000244|PDB:6C98}. FT STRAND 246 251 {ECO:0000244|PDB:6C98}. FT STRAND 253 255 {ECO:0000244|PDB:3M1B}. FT STRAND 257 266 {ECO:0000244|PDB:6C98}. FT TURN 267 269 {ECO:0000244|PDB:5BJT}. FT HELIX 270 272 {ECO:0000244|PDB:6C98}. FT STRAND 273 279 {ECO:0000244|PDB:6C98}. FT STRAND 282 284 {ECO:0000244|PDB:6C97}. FT STRAND 286 288 {ECO:0000244|PDB:6C98}. SQ SEQUENCE 365 AA; 39743 MW; C886C6A1F66A0D89 CRC64; MGVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLS YNSLRGEAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE AFKALGGKGP YTLQGLLGCE LGPDNTSVPT AKFALNGEEF MNFDLKQGTW GGDWPEALAI SQRWQQQDKA ANKELTFLLF SCPHRLREHL ERGRGNLEWK EPPSMRLKAR PSSPGFSVLT CSAFSFYPPE LQLRFLRNGL AAGTGQGDFG PNSDGSFHAS SSLTVKSGDE HHYCCIVQHA GLAQPLRVEL ESPAKSSVLV VGIVIGVLLL TAAAVGGALL WRRMRSGLPA PWISLRGDDT GVLLPTPGEA QDADLKDVNV IPATA // ID FCGRN_MOUSE Reviewed; 365 AA. AC Q61559; Q9QUR0; Q9R2A5; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 12-SEP-2018, entry version 138. DE RecName: Full=IgG receptor FcRn large subunit p51; DE Short=FcRn; DE AltName: Full=IgG Fc fragment receptor transporter alpha chain; DE AltName: Full=Neonatal Fc receptor; DE Flags: Precursor; GN Name=Fcgrt; Synonyms=Fcrn; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. RC STRAIN=A/J, AKR/J, BALB/cJ, C3H/HeJ, DBA/2J, P/J, and TW75; RC TISSUE=Small intestine; RX PubMed=7538537; RA Kandil E., Noguchi M., Ishibashi T., Kasahara M.; RT "Structural and phylogenetic analysis of the MHC class I-like Fc RT receptor gene."; RL J. Immunol. 154:5907-5918(1995). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY. RC STRAIN=FVB/N; TISSUE=Small intestine; RX PubMed=7504013; RA Ahouse J.J., Hagerman C.L., Mittal P., Gilbert D.J., Copeland N.G., RA Jenkins N.A., Simister N.E.; RT "Mouse MHC class I-like Fc receptor encoded outside the MHC."; RL J. Immunol. 151:6076-6088(1993). RN [3] RP PROTEIN SEQUENCE OF 167-173, AND IDENTIFICATION BY MASS SPECTROMETRY. RC STRAIN=OF1; TISSUE=Hippocampus; RA Lubec G., Sunyer B., Chen W.-Q.; RL Submitted (JAN-2009) to UniProtKB. RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Kidney, and Liver; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Binds to the Fc region of monomeric immunoglobulins CC gamma (PubMed:7504013). Mediates the selective uptake of IgG from CC milk and helps newborn animals to acquire passive immunity. IgG in CC the milk is bound at the apical surface of the intestinal CC epithelium. The resultant FcRn-IgG complexes are transcytosed CC across the intestinal epithelium and IgG is released from FcRn CC into blood or tissue fluids (By similarity). Possible role in CC transfer of immunoglobulin G from mother to fetus (By similarity). CC {ECO:0000250|UniProtKB:P13599, ECO:0000250|UniProtKB:P55899, CC ECO:0000269|PubMed:7504013}. CC -!- SUBUNIT: FcRn complex consist of two subunits: p51, and p14 which CC is equivalent to beta-2-microglobulin. It forms an MHC class I- CC like heterodimer. {ECO:0000250|UniProtKB:P13599}. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000250|UniProtKB:P13599}; Single-pass type I membrane CC protein {ECO:0000255}. CC -!- TISSUE SPECIFICITY: Intestinal epithelium of suckling rodents. CC Expressed in neonatal intestine and fetal yolk sac. CC {ECO:0000269|PubMed:7504013}. CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; D37874; BAA07111.1; -; mRNA. DR EMBL; D37873; BAA07110.1; -; Genomic_DNA. DR EMBL; L17022; AAA16904.1; -; mRNA. DR EMBL; D37903; BAA07134.1; -; Genomic_DNA. DR EMBL; D37905; BAA07135.1; -; Genomic_DNA. DR EMBL; D37907; BAA07136.1; -; Genomic_DNA. DR EMBL; D37909; BAA07137.1; -; Genomic_DNA. DR EMBL; D37911; BAA07138.1; -; Genomic_DNA. DR EMBL; D37913; BAA07139.1; -; Genomic_DNA. DR CCDS; CCDS52243.1; -. DR PIR; I56197; I56197. DR RefSeq; NP_034319.2; NM_010189.3. DR UniGene; Mm.3303; -. DR ProteinModelPortal; Q61559; -. DR SMR; Q61559; -. DR IntAct; Q61559; 2. DR MINT; Q61559; -. DR STRING; 10090.ENSMUSP00000003512; -. DR PhosphoSitePlus; Q61559; -. DR MaxQB; Q61559; -. DR PaxDb; Q61559; -. DR PeptideAtlas; Q61559; -. DR PRIDE; Q61559; -. DR Ensembl; ENSMUST00000003512; ENSMUSP00000003512; ENSMUSG00000003420. DR GeneID; 14132; -. DR KEGG; mmu:14132; -. DR UCSC; uc009gtf.2; mouse. DR CTD; 2217; -. DR MGI; MGI:103017; Fcgrt. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOVERGEN; HBG100415; -. DR InParanoid; Q61559; -. DR OrthoDB; EOG091G0KJB; -. DR PhylomeDB; Q61559; -. DR TreeFam; TF336617; -. DR PRO; PR:Q61559; -. DR Proteomes; UP000000589; Chromosome 7. DR Bgee; ENSMUSG00000003420; Expressed in 263 organ(s), highest expression level in small intestine. DR CleanEx; MM_FCGRT; -. DR ExpressionAtlas; Q61559; baseline and differential. DR Genevisible; Q61559; MM. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0019864; F:IgG binding; ISO:MGI. DR GO; GO:0019770; F:IgG receptor activity; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Cell membrane; Complete proteome; Direct protein sequencing; KW Disulfide bond; Glycoprotein; IgG-binding protein; KW Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; KW Receptor; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 21 {ECO:0000250|UniProtKB:P55899}. FT CHAIN 22 365 IgG receptor FcRn large subunit p51. FT {ECO:0000250|UniProtKB:P55899}. FT /FTId=PRO_0000015159. FT TOPO_DOM 22 297 Extracellular. {ECO:0000255}. FT TRANSMEM 298 321 Helical. {ECO:0000255}. FT TOPO_DOM 322 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 202 289 Ig-like C1-type. {ECO:0000255|PROSITE- FT ProRule:PRU00114}. FT REGION 22 110 Alpha-1. {ECO:0000250|UniProtKB:P13599}. FT REGION 111 200 Alpha-2. {ECO:0000250|UniProtKB:P13599}. FT REGION 201 290 Alpha-3. {ECO:0000250|UniProtKB:P13599}. FT REGION 291 297 Connecting peptide. FT MOD_RES 334 334 Phosphoserine. FT {ECO:0000250|UniProtKB:P55899}. FT CARBOHYD 108 108 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 125 125 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 149 149 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 246 246 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 119 182 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 221 275 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 73 73 M -> V (in strain: FVB/N). FT VARIANT 111 111 Y -> F (in strain: P/J). SQ SEQUENCE 365 AA; 40093 MW; 0A2290A54507E0C4 CRC64; MGMPLPWALS LLLVLLPQTW GSETRPPLMY HLTAVSNPST GLPSFWATGW LGPQQYLTYN SLRQEADPCG AWMWENQVSW YWEKETTDLK SKEQLFLEAL KTLEKILNGT YTLQGLLGCE LASDNSSVPT AVFALNGEEF MKFNPRIGNW TGEWPETEIV ANLWMKQPDA ARKESEFLLN SCPERLLGHL ERGRRNLEWK EPPSMRLKAR PGNSGSSVLT CAAFSFYPPE LKFRFLRNGL ASGSGNCSTG PNGDGSFHAW SLLEVKRGDE HHYQCQVEHE GLAQPLTVDL DSSARSSVPV VGIVLGLLLV VVAIAGGVLL WGRMRSGLPA PWLSLSGDDS GDLLPGGNLP PEAEPQGANA FPATS // ID FCGRN_RAT Reviewed; 366 AA. AC P13599; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 12-SEP-2018, entry version 153. DE RecName: Full=IgG receptor FcRn large subunit p51; DE Short=FcRn; DE AltName: Full=IgG Fc fragment receptor transporter alpha chain; DE AltName: Full=Neonatal Fc receptor; DE Flags: Precursor; GN Name=Fcgrt; Synonyms=Fcrn; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 23-39; 176-185 AND RP 282-291, SUBUNIT, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY. RC STRAIN=Wistar; TISSUE=Epithelium {ECO:0000303|PubMed:2911353}; RX PubMed=2911353; DOI=10.1038/337184a0; RA Simister N.E., Mostov K.E.; RT "An Fc receptor structurally related to MHC class I antigens."; RL Nature 337:184-187(1989). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Epithelium; RX PubMed=2534798; RA Simister N.E., Mostov K.E.; RT "Cloning and expression of the neonatal rat intestinal Fc receptor, a RT major histocompatibility complex class I antigen homolog."; RL Cold Spring Harb. Symp. Quant. Biol. 54:571-580(1989). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Prostate; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP FUNCTION. RX PubMed=7298722; DOI=10.1083/jcb.91.1.270; RA Abrahamson D.R., Rodewald R.; RT "Evidence for the sorting of endocytic vesicle contents during the RT receptor-mediated transport of IgG across the newborn rat intestine."; RL J. Cell Biol. 91:270-280(1981). RN [5] RP FUNCTION. RX PubMed=18818657; DOI=10.1038/nature07255; RA He W., Ladinsky M.S., Huey-Tubman K.E., Jensen G.J., McIntosh J.R., RA Bjoerkman P.J.; RT "FcRn-mediated antibody transport across epithelial cells revealed by RT electron tomography."; RL Nature 455:542-546(2008). RN [6] {ECO:0000244|PDB:1FRT} RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 23-291 IN COMPLEX WITH FC AND RP BETA-2-MICROGLOBULIN, FUNCTION, AND SUBUNIT. RX PubMed=7969498; DOI=10.1038/372379a0; RA Burmeister W.P., Huber A.H., Bjorkman P.J.; RT "Crystal structure of the complex of rat neonatal Fc receptor with RT Fc."; RL Nature 372:379-383(1994). RN [7] {ECO:0000244|PDB:3FRU} RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 23-291 IN COMPLEX WITH RP BETA-2-MICROGLOBULIN. RX PubMed=9493268; DOI=10.1016/S0969-2126(98)00008-2; RA Vaughn D.E., Bjorkman P.J.; RT "Structural basis of pH-dependent antibody binding by the neonatal Fc RT receptor."; RL Structure 6:63-73(1998). CC -!- FUNCTION: Binds to the Fc region of monomeric immunoglobulins CC gamma (PubMed:18818657, PubMed:7969498). Mediates the selective CC uptake of IgG from milk and helps newborn animals to acquire CC passive immunity. IgG in the milk is bound at the apical surface CC of the intestinal epithelium. The resultant FcRn-IgG complexes are CC transcytosed across the intestinal epithelium and IgG is released CC from FcRn into blood or tissue fluids (PubMed:7298722, CC PubMed:18818657). Possible role in transfer of immunoglobulin G CC from mother to fetus (By similarity). CC {ECO:0000250|UniProtKB:P55899, ECO:0000269|PubMed:18818657, CC ECO:0000269|PubMed:7298722, ECO:0000269|PubMed:7969498}. CC -!- SUBUNIT: FcRn complex consist of two subunits: p51, and p14 which CC is equivalent to beta-2-microglobulin. It forms an MCH class I- CC like heterodimer. {ECO:0000269|PubMed:2911353, CC ECO:0000269|PubMed:7969498, ECO:0000269|PubMed:9493268}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2911353}; CC Single-pass type I membrane protein {ECO:0000255}. CC -!- TISSUE SPECIFICITY: Intestinal epithelium. CC {ECO:0000269|PubMed:2911353}. CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X14323; CAA32503.1; -; mRNA. DR EMBL; M35495; AAA41611.1; -; mRNA. DR EMBL; BC061975; AAH61975.1; -; mRNA. DR PIR; A37374; A37374. DR RefSeq; NP_203502.1; NM_033351.2. DR RefSeq; XP_006229105.1; XM_006229043.2. DR RefSeq; XP_008757565.1; XM_008759343.2. DR UniGene; Rn.15845; -. DR PDB; 1FRT; X-ray; 4.50 A; A=23-291. DR PDB; 1I1A; X-ray; 2.80 A; A=23-291. DR PDB; 2FRT; Model; -; A/C=23-291. DR PDB; 3FRU; X-ray; 2.20 A; A/C/E=23-291. DR PDBsum; 1FRT; -. DR PDBsum; 1I1A; -. DR PDBsum; 2FRT; -. DR PDBsum; 3FRU; -. DR ProteinModelPortal; P13599; -. DR SMR; P13599; -. DR IntAct; P13599; 1. DR STRING; 10116.ENSRNOP00000027944; -. DR iPTMnet; P13599; -. DR PhosphoSitePlus; P13599; -. DR PaxDb; P13599; -. DR PRIDE; P13599; -. DR Ensembl; ENSRNOT00000027944; ENSRNOP00000027944; ENSRNOG00000020583. DR GeneID; 29558; -. DR KEGG; rno:29558; -. DR UCSC; RGD:61811; rat. DR CTD; 2217; -. DR RGD; 61811; Fcgrt. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000112560; -. DR HOVERGEN; HBG100415; -. DR InParanoid; P13599; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR PhylomeDB; P13599; -. DR EvolutionaryTrace; P13599; -. DR PRO; PR:P13599; -. DR Proteomes; UP000002494; Chromosome 1. DR Bgee; ENSRNOG00000020583; Expressed in 10 organ(s), highest expression level in spleen. DR Genevisible; P13599; RN. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; IDA:RGD. DR GO; GO:0019864; F:IgG binding; IEA:UniProtKB-KW. DR GO; GO:0019770; F:IgG receptor activity; TAS:RGD. DR GO; GO:0006959; P:humoral immune response; TAS:RGD. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Cell membrane; Complete proteome; KW Direct protein sequencing; Disulfide bond; Glycoprotein; KW IgG-binding protein; Immunoglobulin domain; Membrane; Phosphoprotein; KW Receptor; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 22 {ECO:0000269|PubMed:2911353}. FT CHAIN 23 366 IgG receptor FcRn large subunit p51. FT {ECO:0000269|PubMed:2911353}. FT /FTId=PRO_0000015160. FT TOPO_DOM 23 298 Extracellular. {ECO:0000255}. FT TRANSMEM 299 322 Helical. {ECO:0000255}. FT TOPO_DOM 323 366 Cytoplasmic. {ECO:0000255}. FT DOMAIN 203 290 Ig-like C1-type. {ECO:0000255|PROSITE- FT ProRule:PRU00114}. FT REGION 23 111 Alpha-1. {ECO:0000244|PDB:1FRT, FT ECO:0000244|PDB:3FRU, FT ECO:0000269|PubMed:7969498, FT ECO:0000269|PubMed:9493268}. FT REGION 112 201 Alpha-2. {ECO:0000244|PDB:1FRT, FT ECO:0000244|PDB:3FRU, FT ECO:0000269|PubMed:7969498, FT ECO:0000269|PubMed:9493268}. FT REGION 202 291 Alpha-3. {ECO:0000244|PDB:1FRT, FT ECO:0000244|PDB:3FRU, FT ECO:0000269|PubMed:7969498, FT ECO:0000269|PubMed:9493268}. FT REGION 293 298 Connecting peptide. FT MOD_RES 335 335 Phosphoserine. FT {ECO:0000250|UniProtKB:P55899}. FT CARBOHYD 109 109 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 126 126 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 150 150 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 247 247 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 120 183 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 222 276 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT STRAND 29 37 {ECO:0000244|PDB:3FRU}. FT STRAND 45 52 {ECO:0000244|PDB:3FRU}. FT STRAND 55 61 {ECO:0000244|PDB:3FRU}. FT TURN 62 64 {ECO:0000244|PDB:3FRU}. FT HELIX 71 75 {ECO:0000244|PDB:3FRU}. FT HELIX 82 107 {ECO:0000244|PDB:3FRU}. FT STRAND 108 110 {ECO:0000244|PDB:1I1A}. FT STRAND 113 122 {ECO:0000244|PDB:3FRU}. FT STRAND 128 136 {ECO:0000244|PDB:3FRU}. FT STRAND 139 144 {ECO:0000244|PDB:3FRU}. FT TURN 146 148 {ECO:0000244|PDB:3FRU}. FT STRAND 150 152 {ECO:0000244|PDB:1I1A}. FT HELIX 156 165 {ECO:0000244|PDB:3FRU}. FT HELIX 169 180 {ECO:0000244|PDB:3FRU}. FT HELIX 182 193 {ECO:0000244|PDB:3FRU}. FT HELIX 195 198 {ECO:0000244|PDB:3FRU}. FT STRAND 205 212 {ECO:0000244|PDB:3FRU}. FT STRAND 217 230 {ECO:0000244|PDB:3FRU}. FT STRAND 233 238 {ECO:0000244|PDB:3FRU}. FT STRAND 247 252 {ECO:0000244|PDB:3FRU}. FT STRAND 254 256 {ECO:0000244|PDB:3FRU}. FT STRAND 258 267 {ECO:0000244|PDB:3FRU}. FT HELIX 271 273 {ECO:0000244|PDB:3FRU}. FT STRAND 274 279 {ECO:0000244|PDB:3FRU}. FT STRAND 283 285 {ECO:0000244|PDB:3FRU}. FT STRAND 287 289 {ECO:0000244|PDB:3FRU}. SQ SEQUENCE 366 AA; 40169 MW; 8A8BF2873A698BB5 CRC64; MGMSQPGVLL SLLLVLLPQT WGAEPRLPLM YHLAAVSDLS TGLPSFWATG WLGAQQYLTY NNLRQEADPC GAWIWENQVS WYWEKETTDL KSKEQLFLEA IRTLENQING TFTLQGLLGC ELAPDNSSLP TAVFALNGEE FMRFNPRTGN WSGEWPETDI VGNLWMKQPE AARKESEFLL TSCPERLLGH LERGRQNLEW KEPPSMRLKA RPGNSGSSVL TCAAFSFYPP ELKFRFLRNG LASGSGNCST GPNGDGSFHA WSLLEVKRGD EHHYQCQVEH EGLAQPLTVD LDSPARSSVP VVGIILGLLL VVVAIAGGVL LWNRMRSGLP APWLSLSGDD SGDLLPGGNL PPEAEPQGVN AFPATS // ID G1KTN1_ANOCA Unreviewed; 358 AA. AC G1KTN1; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000016954}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000016954, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000016954, ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000016954}; RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSACAP00000016954} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G1KTN1; -. DR Ensembl; ENSACAT00000017289; ENSACAP00000016954; ENSACAG00000017226. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1KTN1; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001646; Chromosome 2. DR Bgee; ENSACAG00000017226; Expressed in 4 organ(s), highest expression level in heart. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 358 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003412949. FT TRANSMEM 306 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 358 AA; 40918 MW; 6F49F516915F0A34 CRC64; MPLSRGAPAV LPFLLAFLVG RGAGSSSHSM RYFVTSVSEP GQQVPQFSYV GYVDDQEFVS YNASTRRYLP KVPWISKVEK NDPDYWERNT LYAQGHERSF RDHLATLAEY YNQSGGLHTF QWMYGCELRN DWSKGGYYQY AYDGRDYISL DKDTLTWMAA DVPAQNTKRK WDADFRDNEY KKTYLEETCI EWLQRYLNYG KETLLRTDKP EVKVTRKEDY DGMETLICRV GGFYPKDIDI DWTRDGEVWL QDVFHGLVSP NSDGTYYTWR SVKVDPKERE RYKCHVEHDG LPNPVDVAWE EPDSNLGLII GCVVGVLLLI AVMAGIAVYF KKSQDGYKAA AASDQGSNSS GTGTAVPI // ID G1L4K3_AILME Unreviewed; 366 AA. AC G1L4K3; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMEP00000001813}; GN Name=AIME-152 {ECO:0000313|Ensembl:ENSAMEP00000001813}; OS Ailuropoda melanoleuca (Giant panda). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; OC Ailuropoda. OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000001813, ECO:0000313|Proteomes:UP000008912}; RN [1] {ECO:0000313|Ensembl:ENSAMEP00000001813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20010809; DOI=10.1038/nature08696; RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., RA Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., RA Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., RA Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., RA Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., RA Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q., RA Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H., RA Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z., RA Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G., RA Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W., RA Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N., RA Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N., RA Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y., RA Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X., RA Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., RA Wang J., Wang J.; RT "The sequence and de novo assembly of the giant panda genome."; RL Nature 463:311-317(2010). RN [2] {ECO:0000313|Ensembl:ENSAMEP00000001813} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ACTA01068778; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ACTA01076778; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9646.ENSAMEP00000001813; -. DR Ensembl; ENSAMET00000001888; ENSAMEP00000001813; ENSAMEG00000001714. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1L4K3; -. DR OMA; SALTKTW; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008912; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008912}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008912}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003413955. FT TRANSMEM 312 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 41185 MW; 2348072D004F80FE CRC64; MSNLLRRTLV LLLSGALAVT ETWAGSHSMR YFHTAVSRPG RGEPRFIAVG YVDDTQFVRF DSDSASRRAE PRAPWMEQEG PEYWDRETRN AKDNAQTFRL DLNNLLGYYN QSEAGPGSHT IQWMHGCDVG PDGRLLRGYE QFAYDGADYI ALNEDLRSWT AADTAAQITR SRWEAAGDAE HDRNYVECTC VEWLRRYLEN GKETLQRAET PNTHVTRHPI SDQRVSLRCW ALGFYPAEIT LTWQQDGEDL TQDTELVETR PAGDGTFQKW AAVVVPSGQE QRYTCHVQHE GLPEPLTLRW EPPPQPTITV PITWIIAGLV LLTVTVVIGA VIWKRKRSGG KGPSYSHAAR DDSARGSNVS LTVPIG // ID G1L6A6_AILME Unreviewed; 366 AA. AC G1L6A6; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMEP00000002421}; OS Ailuropoda melanoleuca (Giant panda). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; OC Ailuropoda. OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000002421, ECO:0000313|Proteomes:UP000008912}; RN [1] {ECO:0000313|Ensembl:ENSAMEP00000002421} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20010809; DOI=10.1038/nature08696; RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., RA Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., RA Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., RA Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., RA Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., RA Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q., RA Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H., RA Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z., RA Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G., RA Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W., RA Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N., RA Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N., RA Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y., RA Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X., RA Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., RA Wang J., Wang J.; RT "The sequence and de novo assembly of the giant panda genome."; RL Nature 463:311-317(2010). RN [2] {ECO:0000313|Ensembl:ENSAMEP00000002421} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ACTA01171291; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1L6A6; -. DR STRING; 9646.ENSAMEP00000002421; -. DR Ensembl; ENSAMET00000002522; ENSAMEP00000002421; ENSAMEG00000002302. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1L6A6; -. DR OMA; RMANEDW; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008912; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008912}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008912}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003414506. FT TRANSMEM 308 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 41216 MW; 610C5183750D1ABA CRC64; MAVSRPRTLL LLLLSGALTL TKTSAGSHSL RYFRTVISRP GNAESRYLEV GYVDDTQFVR FDSDGTSPRA ELRAPWLEQE GPEFWDWKTQ NTRTCTQILR GRLNEVRGYY NESEEAGSHT FQSMVGCDMG PDGRFLRGYF RNAYDGADYI TLNEDLRSWT AANSEAQITR RMWEASGVAQ RSRNYLEGLC MEWLRRHLEN GKETLQRSES PKRQVTRHPI SDREVTLRCW ALGFYPAEIT LTWQRDGEDQ NQNIESVETR PAGDGTFQKW AAVVVPSGEE QRYTCHIQHK ALPEPLTLRW EPPPQPTIPI MGIIAGLVLL VVTGAVVAGA TMWRKKHAGG KGGSYSQAES NMGMTGSSPS LCLLHV // ID G1LSG8_AILME Unreviewed; 149 AA. AC G1LSG8; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 20-JUN-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMEP00000010008}; GN Name=LOC105234428 {ECO:0000313|Ensembl:ENSAMEP00000010008}; OS Ailuropoda melanoleuca (Giant panda). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; OC Ailuropoda. OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000010008, ECO:0000313|Proteomes:UP000008912}; RN [1] {ECO:0000313|Ensembl:ENSAMEP00000010008} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20010809; DOI=10.1038/nature08696; RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., RA Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., RA Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., RA Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., RA Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., RA Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q., RA Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H., RA Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z., RA Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G., RA Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W., RA Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N., RA Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N., RA Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y., RA Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X., RA Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., RA Wang J., Wang J.; RT "The sequence and de novo assembly of the giant panda genome."; RL Nature 463:311-317(2010). RN [2] {ECO:0000313|Ensembl:ENSAMEP00000010008} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ACTA01003591; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ACTA01171584; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ACTA01179582; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ACTA01187580; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ACTA01195578; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMET00000010445; ENSAMEP00000010008; ENSAMEG00000009534. DR GeneTree; ENSGT00740000114936; -. DR OMA; KTHITHH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008912; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008912}; KW Reference proteome {ECO:0000313|Proteomes:UP000008912}. FT DOMAIN 81 149 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 149 AA; 16995 MW; 338907EACA24D200 CRC64; PDGRFLRGYS QLAYDGADYI ALNEDLRSWT AADTAAQITR RKWEAAGAAE QQRNELEVTC VEWLRRYLEM GNKTLLRTDP PKTHVTYHPL TDHKVTLRCW ALGFYPVEIT LTWQQDGEDL TQDTELVEPR PAGDGTFQKW VAVVVPSGE // ID G1LXN2_AILME Unreviewed; 308 AA. AC G1LXN2; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 20-JUN-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMEP00000011837}; OS Ailuropoda melanoleuca (Giant panda). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; OC Ailuropoda. OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000011837, ECO:0000313|Proteomes:UP000008912}; RN [1] {ECO:0000313|Ensembl:ENSAMEP00000011837} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20010809; DOI=10.1038/nature08696; RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., RA Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., RA Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., RA Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., RA Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., RA Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q., RA Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H., RA Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z., RA Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G., RA Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W., RA Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N., RA Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N., RA Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y., RA Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X., RA Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., RA Wang J., Wang J.; RT "The sequence and de novo assembly of the giant panda genome."; RL Nature 463:311-317(2010). RN [2] {ECO:0000313|Ensembl:ENSAMEP00000011837} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ACTA01052609; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1LXN2; -. DR PRIDE; G1LXN2; -. DR Ensembl; ENSAMET00000012338; ENSAMEP00000011837; ENSAMEG00000011252. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1LXN2; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008912; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008912}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000008912}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 308 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003414199. FT DOMAIN 204 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 308 AA; 35116 MW; 6BE65C3C40D41A4F CRC64; MASVLLSLLL LLGPAVPQET HTGPYSLSFF YTGLSRPRDG FPSFQATAYL NDQDFFHYDS EDRKAIPRYP WSQMEGIEDW EKESELQKAR EDIFMVTLKD IMDYYKDKEG SHTFQGMFGC ELQSNKSSGA FWRYAYDGRN FIEFNKEIPA WVPQDPAALN TKQKWEAEEV YVLRAKAYLE EECPAMLRGY LQYGKTYLDR QDPPSLSITS HGTPGETQTL KCRADGFYPR EIELHWIQGD DTQETESRGD VLPSGNSTYQ SWVVLSVSPQ GRASDSYSCR VTHSSLAQPL TVLWPGARAE GSQGAWEQ // ID G1M602_AILME Unreviewed; 355 AA. AC G1M602; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 12-SEP-2018, entry version 48. DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSAMEP00000014770}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSAMEP00000014770}; OS Ailuropoda melanoleuca (Giant panda). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; OC Ailuropoda. OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000014770, ECO:0000313|Proteomes:UP000008912}; RN [1] {ECO:0000313|Ensembl:ENSAMEP00000014770} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20010809; DOI=10.1038/nature08696; RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., RA Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., RA Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., RA Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., RA Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., RA Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q., RA Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H., RA Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z., RA Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G., RA Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W., RA Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N., RA Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N., RA Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y., RA Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X., RA Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., RA Wang J., Wang J.; RT "The sequence and de novo assembly of the giant panda genome."; RL Nature 463:311-317(2010). RN [2] {ECO:0000313|Ensembl:ENSAMEP00000014770} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ACTA01001007; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ACTA01009007; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ACTA01017007; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_002917885.1; XM_002917839.3. DR RefSeq; XP_019653751.1; XM_019798192.1. DR RefSeq; XP_019653752.1; XM_019798193.1. DR ProteinModelPortal; G1M602; -. DR STRING; 9646.ENSAMEP00000014770; -. DR Ensembl; ENSAMET00000015378; ENSAMEP00000014770; ENSAMEG00000013998. DR GeneID; 100472176; -. DR KEGG; aml:100472176; -. DR CTD; 2217; -. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1M602; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008912; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008912}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008912}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 355 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003415187. FT TRANSMEM 300 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 355 AA; 38728 MW; A3CD6495EEEEF679 CRC64; MGVPRPRTWG LGFLLVLLPT LRAAESHLSL LYHLTAVSAP APGTPAFWVS GWLGPQQYLS YNNLRAQAEP CGAWVWENQV SWYWEKETTD LRNKQELFLE GLRALGEGGP YTLQGLLGCE LGPANASVPV AKFALNGEDF MNFDPKLGTW NGEWPETETI RKTWTQHAGA VSKERTFLLN SCPQRLLGHL ERGRGNLEWK EPPSMRLKAR PGSPGFSVLT CSAFSFYPPE LQLRFLRNGL AAGSGEGDLG PNGDGSFHAW SSLTVKSGDE HHYRCLVQHA GLPQPLTVEL ESPAKSSVPV VGIVVGFLLL TAVAAGGALL WRRMRRGLPA PWMSLRGDDV GALLPTPGVA KDVDS // ID G1MA46_AILME Unreviewed; 354 AA. AC G1MA46; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMEP00000016219}; DE Flags: Fragment; OS Ailuropoda melanoleuca (Giant panda). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; OC Ailuropoda. OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000016219, ECO:0000313|Proteomes:UP000008912}; RN [1] {ECO:0000313|Ensembl:ENSAMEP00000016219} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20010809; DOI=10.1038/nature08696; RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., RA Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., RA Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., RA Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., RA Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., RA Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q., RA Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H., RA Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z., RA Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G., RA Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W., RA Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N., RA Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N., RA Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y., RA Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X., RA Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., RA Wang J., Wang J.; RT "The sequence and de novo assembly of the giant panda genome."; RL Nature 463:311-317(2010). RN [2] {ECO:0000313|Ensembl:ENSAMEP00000016219} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ACTA01027897; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1MA46; -. DR STRING; 9646.ENSAMEP00000016219; -. DR Ensembl; ENSAMET00000016893; ENSAMEP00000016219; ENSAMEG00000015368. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1MA46; -. DR OMA; GINDRTE; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008912; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008912}; KW Reference proteome {ECO:0000313|Proteomes:UP000008912}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 354 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003414734. FT DOMAIN 192 277 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSAMEP00000016219}. SQ SEQUENCE 354 AA; 39930 MW; D63B75A16AE1CE98 CRC64; LLLLLSGALA VTETWAGSHS LRYFSIALSR PGRGEPRYWE VGYVDDTQFV QFDSDAANPR MEPRAPWVEQ ERPEYWDQET RGAEDHARIS RRNLRVALGC YNQSEAGSHA LQGMFGCDVG PDGRLLRGYE QLAYDGAHYI ALNEDLRSWT AADRWEAAGG AEHSRNYLEV TCVESLRRYL KNGETLQRAE PPKTHVSHHP ISDHDVTLRC WALGFYAEIT LTWHRDGEDL PQDTELVKTR PAGDGTFQKW AAVVVPSGQE QRYTCHVQHE ALPEPITLRW GYRSGPLTFP SLSRATSSAH RGRHCWSDLF VIAAVVVAVM WRKTRSGRRT GNYCHAVCKQ DPVGSSPSRC SCSF // ID G1MBW1_AILME Unreviewed; 347 AA. AC G1MBW1; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 23-MAY-2018, entry version 45. DE SubName: Full=Hemochromatosis {ECO:0000313|Ensembl:ENSAMEP00000016839}; GN Name=HFE {ECO:0000313|Ensembl:ENSAMEP00000016839}; OS Ailuropoda melanoleuca (Giant panda). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; OC Ailuropoda. OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000016839, ECO:0000313|Proteomes:UP000008912}; RN [1] {ECO:0000313|Ensembl:ENSAMEP00000016839} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20010809; DOI=10.1038/nature08696; RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., RA Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., RA Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., RA Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., RA Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., RA Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q., RA Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H., RA Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z., RA Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G., RA Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W., RA Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N., RA Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N., RA Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y., RA Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X., RA Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., RA Wang J., Wang J.; RT "The sequence and de novo assembly of the giant panda genome."; RL Nature 463:311-317(2010). RN [2] {ECO:0000313|Ensembl:ENSAMEP00000016839} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ACTA01060153; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ACTA01068153; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ACTA01076153; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ACTA01084153; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1MBW1; -. DR STRING; 9646.ENSAMEP00000016839; -. DR Ensembl; ENSAMET00000017530; ENSAMEP00000016839; ENSAMEG00000015938. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1MBW1; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008912; Unassembled WGS sequence. DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl. DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:Ensembl. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl. DR GO; GO:0030881; F:beta-2-microglobulin binding; IEA:Ensembl. DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl. DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0071281; P:cellular response to iron ion; IEA:Ensembl. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:Ensembl. DR GO; GO:1904283; P:negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:Ensembl. DR GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; IEA:Ensembl. DR GO; GO:1900121; P:negative regulation of receptor binding; IEA:Ensembl. DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; IEA:Ensembl. DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR GO; GO:1904434; P:positive regulation of ferrous iron binding; IEA:Ensembl. DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl. DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IEA:Ensembl. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; IEA:Ensembl. DR GO; GO:1900390; P:regulation of iron ion import; IEA:Ensembl. DR GO; GO:2000008; P:regulation of protein localization to cell surface; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008912}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008912}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 347 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003415814. FT TRANSMEM 304 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 347 AA; 39063 MW; 377CA0559DE65B06 CRC64; DSLAMPALLL LLLLLRAVAS HRPPRSHSLR FLFMGASVPD LGLPLFEALG YVDDQLFVSY SHESRRAEPR APWVRGGAAS QLWLQLSQSL KGWDHMFIVD FWTIMDNHNR SKESHTLQVI LGCEVQEDNS TRGFWKYGYD GQNHLEFCPE TLDWRAAEPK AQATKLEWEV NKIRAKQNRA YLERDCPEQL QRLLELGRGV LDRQVPPSVK VTHHVASAVS TLRCQALNFY PRSITMKWLK DRQPLDAQDV EPEDVLPNGD GTFQGRVALV VAPGEERRYA CRVEHSGLDQ PLTATWEAPV PGTVLVGVVG GVAVCITLFL TGILFRVLRK RQASRGAMGD YVLAECK // ID G1MIW1_AILME Unreviewed; 218 AA. AC G1MIW1; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMEP00000019296}; DE Flags: Fragment; OS Ailuropoda melanoleuca (Giant panda). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; OC Ailuropoda. OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000019296, ECO:0000313|Proteomes:UP000008912}; RN [1] {ECO:0000313|Ensembl:ENSAMEP00000019296} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20010809; DOI=10.1038/nature08696; RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., RA Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., RA Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., RA Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., RA Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., RA Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q., RA Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H., RA Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z., RA Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G., RA Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W., RA Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N., RA Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N., RA Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y., RA Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X., RA Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., RA Wang J., Wang J.; RT "The sequence and de novo assembly of the giant panda genome."; RL Nature 463:311-317(2010). RN [2] {ECO:0000313|Ensembl:ENSAMEP00000019296} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ACTA01178234; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1MIW1; -. DR Ensembl; ENSAMET00000020062; ENSAMEP00000019296; ENSAMEG00000018259. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G1MIW1; -. DR OMA; CKMWLEE; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000008912; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000008912}; KW Reference proteome {ECO:0000313|Proteomes:UP000008912}. FT DOMAIN 6 179 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 58 78 {ECO:0000256|SAM:Coils}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSAMEP00000019296}. SQ SEQUENCE 218 AA; 25035 MW; 57E2E5D3425ED600 CRC64; FADVLCLFYT FSIISPARPG QPWYKIEGQI NGSPFVYYDS QSKELKPVGR LGLQLKDIPF WERQKETLED SCNELKSKPL EIRAETSSNR DFCTLQGRLT CERGANRECR SFWQFHFNEQ ITSDFKLENR KWTVDHSGDQ WLKDMLDSDR ELTEFLMRVS DGDCMSWLQQ ISEHLEEMRE TTGAPATTPG TPQVKGAAIR PITSILSVLL TCLTLLGI // ID G1MIW3_AILME Unreviewed; 246 AA. AC G1MIW3; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 20-JUN-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMEP00000019298}; OS Ailuropoda melanoleuca (Giant panda). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; OC Ailuropoda. OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000019298, ECO:0000313|Proteomes:UP000008912}; RN [1] {ECO:0000313|Ensembl:ENSAMEP00000019298} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20010809; DOI=10.1038/nature08696; RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., RA Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., RA Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., RA Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., RA Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., RA Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q., RA Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H., RA Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z., RA Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G., RA Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W., RA Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N., RA Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N., RA Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y., RA Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X., RA Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., RA Wang J., Wang J.; RT "The sequence and de novo assembly of the giant panda genome."; RL Nature 463:311-317(2010). RN [2] {ECO:0000313|Ensembl:ENSAMEP00000019298} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ACTA01194230; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1MIW3; -. DR Ensembl; ENSAMET00000020064; ENSAMEP00000019298; ENSAMEG00000018260. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G1MIW3; -. DR OMA; QIAKRPL; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000008912; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000008912}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008912}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 12 37 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 32 205 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 84 104 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 246 AA; 28490 MW; CD18CF14C43D966B CRC64; MVRTGTSNFS LGLLRLFILP VWLAAGCRHV LCLFYTFSII SPARPGQPWY KIEGQINGSP FVYYDSQSKE LKPVGRLGLQ LKDIPFWERQ KETLEDSCNE LKTKPLKIRA ETSSNRDFRT LQGRLTCERG ANREHRSFWW FHLNEQITSD FKLENRKWTV DHSGDQWLKD MLDSDRELTE FLMRVSDGDC MSWLQQISEH LEEMRETTVP PTTQPDTVQV RARARAIGSS TWILALFLSC AAITAI // ID G1NYD0_MYOLU Unreviewed; 366 AA. AC G1NYD0; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 20-JUN-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000002414}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000002414, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000002414, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000002414} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02056979; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000002414; -. DR Ensembl; ENSMLUT00000002657; ENSMLUP00000002414; ENSMLUG00000024951. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1NYD0; -. DR OMA; CEGETHP; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003417324. FT TRANSMEM 310 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 40990 MW; 5A416BFEDABDFB13 CRC64; MRVLRPPALL LLLSGALVLT PSWAGPHSLM YFFTAMSRPG RGEPRYLLVG YVDDTQFVRF DSDAPNPRME PRAPWMQQPW VELERPGYWD RETQRAKGDA QTFRMELQTT LDYYNQSEDG SHTLQRMVGC HVGPEGRLLR GYMQYAYDGA DYIALNEDLT SWTTVDMVAQ IIQRKWEAAG GADHVRSYLE GECMEWLQIH LEKGKETLQR ADPPKAHMTH HPVSDHEVTL RCWALGFYPA DISLTWQRDG EDQTQDMELV ETRPAGDGTF QKWAAVGVPP GEEQRYTCHV QHEGLPEPLT LRWEPPPHTF IFIIMGIAGG LVLLGAVAGA VMWGRRRSGG KGGSYAQAAS SDSGQGSDVS LSASKG // ID G1P620_MYOLU Unreviewed; 365 AA. AC G1P620; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000005486}; GN Name=LOC102424768 {ECO:0000313|Ensembl:ENSMLUP00000005486}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000005486, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000005486, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000005486} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02047344; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000005486; -. DR Ensembl; ENSMLUT00000006006; ENSMLUP00000005486; ENSMLUG00000006006. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1P620; -. DR OMA; EDRTHNT; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003417396. FT TRANSMEM 311 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 40556 MW; 76A3A06550B87261 CRC64; MRVLSPPTLF LLLSGALVLT PSWAGPHSLM YFFTIVSWPG RGEPRFLSVG YVDDTQFVRF DSDAASPRME PRAPWMQQPW VERERPGYWE GQTQINKETA QTFRGNLEIL RGYYNQSEDG PHTLQRMSGC DVGPEGRLLR GYEQYAYDGA DYIALNEDLT SWTAADTAAQ ITRRKWEAAG AAEKKRSYLE GLCVESLLLY LDKGKETLQR ADPPKAHVTR HPVSAREVTL RCWALGFYPA DISLTWQRDG EDQTQDMELV ETRPAGDGTF QKWVAVGVPP GEEQRYTCHV QHEGLPEPLT LRWEPPSQTS IIIIITGIAV VLVLLGAVAG IVMWRWRRSG GNGGSCAQAA SSGGAQGSDV PLSAL // ID G1PC78_MYOLU Unreviewed; 241 AA. AC G1PC78; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000008009}; DE Flags: Fragment; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000008009, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000008009} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The genome sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000008009} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02056290; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1PC78; -. DR Ensembl; ENSMLUT00000008790; ENSMLUP00000008009; ENSMLUG00000025459. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1PC78; -. DR OMA; TDPERTH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 187 211 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 91 177 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMLUP00000008009}. SQ SEQUENCE 241 AA; 26506 MW; 695D4541D1630DD5 CRC64; IQSMYGCEVG PDGRLLRGYS QWAYDGVDYI ALNEDLTSWT AADMAAQITK RKWEAAGDAE DWRSYLEGRC VEYLHIYLEK GKEKLQRADP PKAHVTQHPA SASEVTLRCW ALGFYPADIS LTWQRDGEDQ TQDMELVETR PAGDGTFQKW AAVGVPPGEE QRYTCHVQHE GLPELLTLRW EPPSQTFIFI IIMGIAGGLV LLGAVAGAVM WGRRRLGGEG VGPECSDSGQ GSDVSLSASK G // ID G1PCV8_MYOLU Unreviewed; 369 AA. AC G1PCV8; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000008271}; DE Flags: Fragment; GN Name=LOC102431662 {ECO:0000313|Ensembl:ENSMLUP00000008271}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000008271, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000008271, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000008271} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02056982; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000008271; -. DR Ensembl; ENSMLUT00000009079; ENSMLUP00000008271; ENSMLUG00000027394. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1PCV8; -. DR OMA; RITQRFY; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 369 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003416921. FT TRANSMEM 313 336 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 217 305 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMLUP00000008271}. SQ SEQUENCE 369 AA; 41511 MW; CAE22A6F2C91B0A5 CRC64; TPRMRVRRPP TLLLLLSGAL VLTPSWAGPH SLRYFSTSVS PPGRGKIRFL SVGYVDYTQF VRFDSDVPNP REEPRAPWMQ QPWVEHEDPG YWDRQTQINK DEAQTFRLDL QTLRGYYNQS EDGSHTVQVM YGCEVGPDGR LLRGYEQHAY DGADYIALNE DLASWTAADL AAQITRRKWE AEGVAERLRS YLEGECVKWL RLYLEKGKET LQRAEPPKAH VTHHLVSARE VTLRCWALGF YPADISLTWQ RDGEDQTQDM ELVETRPAGD GTFQKWAAVG VPPGEEQRYT CHVQHEGLPE PLTLRWEPPS QTFIFIIMDI AGVLVLLGIV FATVMWGKRR SGGKGGSYAQ AASSDSAQGS GVSLSASKG // ID G1PHG2_MYOLU Unreviewed; 338 AA. AC G1PHG2; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 23-MAY-2018, entry version 47. DE SubName: Full=Hemochromatosis {ECO:0000313|Ensembl:ENSMLUP00000010112}; GN Name=HFE {ECO:0000313|Ensembl:ENSMLUP00000010112}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010112, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000010112, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000010112} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02052535; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAPE02052536; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1PHG2; -. DR STRING; 59463.ENSMLUP00000010112; -. DR Ensembl; ENSMLUT00000011095; ENSMLUP00000010112; ENSMLUG00000011088. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1PHG2; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl. DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:Ensembl. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl. DR GO; GO:0030881; F:beta-2-microglobulin binding; IEA:Ensembl. DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl. DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0071281; P:cellular response to iron ion; IEA:Ensembl. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:Ensembl. DR GO; GO:1904283; P:negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:Ensembl. DR GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; IEA:Ensembl. DR GO; GO:1900121; P:negative regulation of receptor binding; IEA:Ensembl. DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; IEA:Ensembl. DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR GO; GO:1904434; P:positive regulation of ferrous iron binding; IEA:Ensembl. DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl. DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IEA:Ensembl. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; IEA:Ensembl. DR GO; GO:1900390; P:regulation of iron ion import; IEA:Ensembl. DR GO; GO:2000008; P:regulation of protein localization to cell surface; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 278 304 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 181 267 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 338 AA; 37147 MW; EAD53DF4A3D93F18 CRC64; GSHSLRYLLM GATEPDLGLP LFQAAGFVDE QLFVFYDHES RRAEPRAPWV RAAGPLWLQL SQSLKGWDHM FTLDFWTIMD NRNHSSAGPH TLQVPVGCSV GAGQTSTSGF WKYGYDGEEP PGGSAPRRPW SPGALGHQDG VGRERESGRG QNRAYLERLC PEQLGRLLEL GTGVLDRQVP PSVRVTRRVA SEATTLRCQA LSFYPPDVTM TWLKDRQPLD AKDAEPRDLL PNGDGTYQAQ VALAVPPGEE RRYACQVQHP GLEQPLAAAW EPSMSGALVF GIICGTLMGV LIVIFFTGVL FRFLRRRRAS QTRGPVHKIR ALGDGVWGSL GGVVIPKP // ID G1PHZ3_MYOLU Unreviewed; 356 AA. AC G1PHZ3; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000010307}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010307, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000010307} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The genome sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000010307} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02021977; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMLUT00000011312; ENSMLUP00000010307; ENSMLUG00000029414. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1PHZ3; -. DR OMA; THHHISE; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 356 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003418226. FT TRANSMEM 307 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 356 AA; 39896 MW; B5671A164F6D5EB1 CRC64; MLLTRSPTLL RLLLGALALT QTWAGPDSPR LYSTVKYQQG RTVFWFLPGC VNYIQLEWFN RNSESQRAEL RALWMEQMKL GFSDMSNQNA RGDAHISRLN LQTLPGYYNQ SQDGSHTIQE MGCDMGPDGR LVPGYDQSAY DGTDYIALNE DLRSWTSAST TAQITQHKWE EAGVAEERRH YLEGSCLEFL HIVLEKGKEV MQRADPPKTH VTHHPISDHE VTLRCWALGF YPADISLSWQ RDGEEQTQDM ELVETRPAGD GTFQKWAALV VPRGEEQRYM CHVQHEGLPE PLTLRWEPRP QATIPPVGLV VGLVILGAVV TGAVMWRRKR SGGQGGSYAQ AASSDGAHSS DVSLTA // ID G1PLQ2_MYOLU Unreviewed; 166 AA. AC G1PLQ2; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000011795}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000011795, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000011795, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000011795} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02068472; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000011795; -. DR Ensembl; ENSMLUT00000012966; ENSMLUP00000011795; ENSMLUG00000012964. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G1PLQ2; -. DR OMA; QIAKRPL; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}. FT DOMAIN 12 163 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 50 77 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 166 AA; 18486 MW; DDF5C8CE8706E9B6 CRC64; AKSLDYKFTV TPNGQPWCEI QGQVNGNTFL HYTCGSQEVK LFSVLDVNAT QAWNQQRDTL QDVVEELKKT LLDIKAEITA PRGTGPLSLQ SSMMCEQESN GRTGASWEFG LDGQISVHFD PRNGNWAVLH GEGRVLKQTL ASDKDMTNLL ARTSVGDCRK WLKEVL // ID G1PNR4_MYOLU Unreviewed; 365 AA. AC G1PNR4; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000012602}; DE Flags: Fragment; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000012602, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000012602} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The genome sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000012602} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02056021; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000012602; -. DR Ensembl; ENSMLUT00000013850; ENSMLUP00000012602; ENSMLUG00000026002. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1PNR4; -. DR OMA; SALTKTW; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003417270. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMLUP00000012602}. SQ SEQUENCE 365 AA; 40504 MW; 71BB5DA0592D5823 CRC64; LSPPTLLLLL SGALVLTPSW AGPHSLRYFY TSVSRPGRGE PRFLAVGYVD DTQFVRFDSD APNPKAEPRA PWMQQPWVEQ EDPEYFHRST RIFKGAAQID RGNLQTLRGY YNQSEDGSHT IQRMFGCDLG PDGRLLRGYN QYAYDGADYI ALNEDLTSWT AADMAAQITK RKWEAAGDAE HYRSYLEGLC VKWLQIYLDK GKETLQRADP PKAHVTHHPV SAREVTLRCW ALGFYPADIS LTWQRDGEDQ TQDMELVETR PAGDGTFQKW AAVGVPPGEE QRYTCHVQHE GLPEPLTLKW EPPSYTFFII VGIAGGLVLL GAVAAAVMWG RRRSGGKGGS YSQAASSDSG QGSDVSLSAS KGETL // ID G1PP04_MYOLU Unreviewed; 158 AA. AC G1PP04; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000012709}; DE Flags: Fragment; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000012709, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000012709} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000012709} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02057553; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMLUT00000013969; ENSMLUP00000012709; ENSMLUG00000013968. DR GeneTree; ENSGT00740000114936; -. DR OMA; ECAWIGS; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}. FT DOMAIN 69 157 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMLUP00000012709}. SQ SEQUENCE 158 AA; 18251 MW; EAEF0A3F6BA37843 CRC64; AYDGTDYLAL NEDLRSWTAS NTAAQITRLK WEAEGVAEER RHYLQGECLE WLSRYLAMGK EALQRADPPK THVTHHPISD REVTLRCWAL GFYPAEISLS WQRDGDEQTQ DMELVETRPA GDGTFQKWAA LVVPRGEEQR YTCHVQHEGL PEPLTLRW // ID G1PSE8_MYOLU Unreviewed; 337 AA. AC G1PSE8; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 42. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSMLUP00000014092}; GN Name=MR1 {ECO:0000313|Ensembl:ENSMLUP00000014092}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000014092, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000014092, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000014092} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02018364; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1PSE8; -. DR STRING; 59463.ENSMLUP00000014092; -. DR Ensembl; ENSMLUT00000015464; ENSMLUP00000014092; ENSMLUG00000015463. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1PSE8; -. DR OMA; GYVDSHP; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 337 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003417418. FT TRANSMEM 296 319 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 278 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 337 AA; 39063 MW; 3DC70365CE956E28 CRC64; FIILLHLIIR LFMKQTDTGT HSLRYFRLGV SEPGHGIPEF LSVGYVDSHP ITTYDSFSRL KEPRAPWMAE HLAPDHWERY TQLLRGWQQT FKVELERLQR HYNHSGFHTY QRMIGCELLE DGSTTGFLQY AYDGQDFLIF DKDTLSWTAV DNVAHITKRA WEANWHELQY QKNWLEEECI AWLKRFLEYG KDTLQRTEPP LVKVSRKETF PGITTLVCRA YGFYPPEISM IWMKNGEEMI QEMDYGGVLP SGDGTYQTWV SVELDSESSD LYSCHVEHCD VQMVLQVPQG SETTLLVIKA VSGSIVLAMV LAGVGFLAWR RKPQEKNEVI YLPAPDQ // ID G1PT50_MYOLU Unreviewed; 385 AA. AC G1PT50; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000014385}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000014385, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000014385} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The genome sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000014385} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02056293; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000014385; -. DR Ensembl; ENSMLUT00000015791; ENSMLUP00000014385; ENSMLUG00000023754. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1PT50; -. DR OMA; QPRFIAV; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 385 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003419009. FT TRANSMEM 310 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 385 AA; 43179 MW; 88EDF2EF59F6F0ED CRC64; MRILRPPTLL LLLSGALVLT PSWAGPHSLR YFLTSVSRPG RGEPRFLSVG YVDDTQFVRF DSDAPNPREE PRAPWMQQPW VEREDPGYWE ENTLRVKGHA QFFRVNLQNL RGYYNQSEDG SHTIQVMRGC DVGPDGRLLR GYEQHAYDGV DYIALNEDLT SWTAADMAAQ ITKCKWEAAR VAERYRIYVE GECMPWLRIY LEKGKETLQR ADPPKAHVTH HPVSASEVTL RCWALGFYPA DISLTWQRDG EDQTQDMELV ETRPAGDGTF QKWAAVVVPP GEEQRYTCHV QHEGLPQPLT LRWEPPSHTF IIIMVIAGGL VLLGAVAGAV MWWRRRSGGK GGSYAQAASS DSGQGSDVSL SASKEREAAA LWGLSDGRCV HTPTS // ID G1PVL4_MYOLU Unreviewed; 372 AA. AC G1PVL4; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 20-JUN-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000015384}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000015384, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000015384, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000015384} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02064302; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1PVL4; -. DR STRING; 59463.ENSMLUP00000015384; -. DR Ensembl; ENSMLUT00000016879; ENSMLUP00000015384; ENSMLUG00000024543. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1PVL4; -. DR OMA; MKNATQT; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 372 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003418712. FT TRANSMEM 310 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 372 AA; 41237 MW; 135C23AE7F6AFA00 CRC64; MRVLSPPTLL LLLSGALVLT PSWAGPHSLR YFYTIVSRPG RGEPRFFVVG YVDDTQFVRF DSDAASPRAE PGAPWMQQPW VEQVYLGYWE EQTQIFKAAA QTYRGNLEIL RGHYNQSEDG SHTYQCMFGC DVGPDGRLLR GYSQWAYDGA DYIALNEDLT SWTGADMAAQ ITKRKWEAEG EAERERSYLE GLCVESLLIY LEKGKETLQR ADPPKAHVTH HPISDHEVTL RCWVLGFYPA DISLTWQRDG EDQTQDMELV ETRPAGDGTF QKWAAVGVPP GEEQRYTCHV QHEGLPEPLT LRWEPPSQTF IFIIMGIAGG LVLLGAVAGA VMCGRRCSGS FLPMGGKGGS YAQAASSDRA QGSDMSLSAS KG // ID G1PY98_MYOLU Unreviewed; 367 AA. AC G1PY98; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 20-JUN-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000016430}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000016430, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000016430, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000016430} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02061973; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000016430; -. DR Ensembl; ENSMLUT00000022747; ENSMLUP00000016430; ENSMLUG00000025813. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1PY98; -. DR OMA; WDRNTRN; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 367 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003417709. FT TRANSMEM 308 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 367 AA; 41562 MW; 2509B0D2A1475462 CRC64; MLLTGPPALL LLLWGALALT QTWAGPHSLR LFSTAVSRPG RGEARYLEVV YVDDTQFERF DSDSDSQRAE PRAPWMEQME PGYWYLSTRN AKRDAQIFRL NLQTALGYYN QSRDGSHTYQ WMYGCDMGPD GRLVRGYYQY AYDGTDYLAL NEDLSSWTAA DTAAQITRRK WEEALEAEQV RKELEGRCLE WLRRYLAMGK EELQRADPPK THVTHHPISD REVTLRCWAL GFYPADISLS WQRDGEEQTQ DMELVETRPA GDGNFQKWAA LVVPPGEEQR YTCHVQHEGL PEPLTLRWEP PPWATIPLVG LVVGLVILGA VVTGAVITGA VMWRRRKRSG GKGGSYFQAA RNDSVQGSDV SLMASKG // ID G1PYN0_MYOLU Unreviewed; 93 AA. AC G1PYN0; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000016562}; DE Flags: Fragment; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000016562, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000016562} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The genome sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000016562} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02055660; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1PYN0; -. DR Ensembl; ENSMLUT00000029632; ENSMLUP00000016562; ENSMLUG00000023140. DR GeneTree; ENSGT00900000141162; -. DR InParanoid; G1PYN0; -. DR OMA; LEYWDRE; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}. FT DOMAIN 1 93 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMLUP00000016562}. SQ SEQUENCE 93 AA; 10990 MW; DA1EE83BA289E2FA CRC64; HSLMYFDTIV SRPGRGEPRF LSVGYVDDTQ FVRFDSDAPN PRMEPRAPWM QQPWVEQDDP GYWDRNTQIS KSNAQAFQRS LEILRGYYNQ SED // ID G1PZ63_MYOLU Unreviewed; 362 AA. AC G1PZ63; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000016745}; GN Name=LOC102429581 {ECO:0000313|Ensembl:ENSMLUP00000016745}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000016745, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000016745, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000016745} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02059745; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000016745; -. DR Ensembl; ENSMLUT00000028850; ENSMLUP00000016745; ENSMLUG00000026917. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1PZ63; -. DR OMA; GYCQEAY; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003417700. FT TRANSMEM 310 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40610 MW; A660A55E2BF1C50B CRC64; IRVMRPPTLL LLLTGALVLT PSWAGPHSLR YFLTAVSRPG RGEPRYLEVG YVDDTQFVRF DSDAPNPRME PRAPWMQQPW VEREDPGYWE EETLRAKGAA QTFRVNLQNL RGYYNLSEDG SHTFQNMYGC DLGPDGRLLR GYKQYAYDGA DYISLNEDLT SWTAADMAAQ ITKRKWEGAG VAEHDRSYLE GLCVKFLRIH LEKGKETLQR ADPPKAHVTH HPVSAREVTL RCWALGFYPA DISLTWQRDG EDQTQDMELV ETRPAGDGTF QKWAAVGVPP GEEQRYTCHV QHEGLPEPLT LRWEPPSHTF IFIIMGIAGV LVLLGAVSGA VMWGRRRSGG TGGSYAQAAS EYGGGTPESL RQ // ID G1PZV3_MYOLU Unreviewed; 69 AA. AC G1PZV3; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000016985}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000016985, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000016985} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000016985} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02055906; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAPE02055907; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAPE02055908; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMLUT00000026685; ENSMLUP00000016985; ENSMLUG00000023888. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}. FT DOMAIN 1 69 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 69 AA; 7938 MW; 1D20F0543F7DC0AE CRC64; MGPDGRLLRG YHQSAYDGTD YLALNEDLRS WTAADTAAQI TRRKWEEAGE AERLRNGLEG RCLELLHRY // ID G1Q126_MYOLU Unreviewed; 366 AA. AC G1Q126; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 20-JUN-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000017409}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000017409, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000017409, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000017409} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02059527; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000017409; -. DR Ensembl; ENSMLUT00000022641; ENSMLUP00000017409; ENSMLUG00000029318. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1Q126; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003417788. FT TRANSMEM 310 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 40770 MW; EDE561AA3438BE7E CRC64; MRVLSPPTLL LLLSGALVLT PSWAGPHSLR YFSTIVSRPG RGEPRFLAVG YVDDTQLVRF DSDAPNPRAE PRAPWMQQPW VEQVYPGYWD RETEISKSNA QTFRVNLQTL RGYYNQSEDG SHTIQSMFGC DVGPDGRLLR GYVQHAYDGA DYLALNEDLT SWTAADMAAQ ISKRKWESDH WAEEMRNYLE GPCMEWLRIY LDKGKETLQR ADPPKAHVTH HPVSASEVTL RCWALGFYPA DISLTWQRDG EDQTQDMELV ETRPAGDGTF QKWAAVGVPP GEEQRYTCHV QHEGLPEPLT LRWEPPSHTF IFIIMGIAGG LVLLGAVAGA VMWGRRRSGG KGGSYSQAVS SDSGQGSDVS LSASRG // ID G1Q180_MYOLU Unreviewed; 268 AA. AC G1Q180; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 20-JUN-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000017463}; GN Name=LOC102432373 {ECO:0000313|Ensembl:ENSMLUP00000017463}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000017463, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000017463, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000017463} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02048468; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000017463; -. DR Ensembl; ENSMLUT00000030227; ENSMLUP00000017463; ENSMLUG00000025468. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G1Q180; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}. FT DOMAIN 41 188 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 268 AA; 29357 MW; 3D13FCB7A2D24F71 CRC64; SARSCCSYFC FGNPPLLAVS WGIESGPGAP SLGYKFTVTP NGQPWCEIQG QVNGNTFLHY TCGGNKVKLI SVLEMNATQA WSEQRDALQY VVEELKKTLL DIKAEIPATS GPHSLQGSMM CEQESNVLIA ASWEFGLDGQ ISLRFDSKNG HWTVLHGEGI LLKQTLASDR AMTDLLVRTS AGDCRKWLEQ VLCPLSTQGN STEDDLGQQG LGGISMELGS ARLSLSCFHY SCTNHCHSHS PVQGHNQHAH HFGPPCDPYL CNHSWHLR // ID G1Q1Z1_MYOLU Unreviewed; 292 AA. AC G1Q1Z1; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000017724}; DE Flags: Fragment; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000017724, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000017724} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000017724} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02000030; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1Q1Z1; -. DR Ensembl; ENSMLUT00000024889; ENSMLUP00000017724; ENSMLUG00000026717. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1Q1Z1; -. DR OMA; ENECPER; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}. FT DOMAIN 200 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMLUP00000017724}. SQ SEQUENCE 292 AA; 33486 MW; ADDF73A9588DCDF6 CRC64; YGPHISMFSL SLFFFFFAGP YSLSFLFTGV SRPKADIASF QATGFINDQP FFHYDSKSRT AEPLGPWKQV DGMVNWENES QLKQARQDIF METLEDVMGY YRDRVAGNHT FKGTFGCEIR NDSYCGAFWK YAYDGRDYIK FNTEIPAWIP LQPEAVNTKV KWETEGSAQV SKDYLENECP ERLRSYLQYS RPFLDRQDPP SVSITSRVTL GLIRTLTCVA DNFYPEPISM YWTQADSVVE TESWGEGPLS ENGTYQSWVA VKIPSLDRGP YSCHVQHSSL AQPLTVTWNK SQ // ID G1Q2M5_MYOLU Unreviewed; 337 AA. AC G1Q2M5; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000017958}; DE Flags: Fragment; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000017958, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000017958} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000017958} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02062890; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1Q2M5; -. DR Ensembl; ENSMLUT00000024986; ENSMLUP00000017958; ENSMLUG00000025201. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1Q2M5; -. DR OMA; SCEVIHE; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 278 304 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 184 272 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMLUP00000017958}. SQ SEQUENCE 337 AA; 37945 MW; 74F6A4B34DF91F84 CRC64; GPHFLRYFFT AVSPAAGEAR YLEVGYVDDL PFEGFDSDSE SQRAEPRAPW MEQVEPGDWD QSTRNAKRET QIFRESLHNL RGYYNQSEDG SHTFQQMWGC DMGPDGRLLR GYDQYAYDGT DYIALNENLR SWTAADTAAQ ITQRKWEEAG EAERLRNILE GRCMELLHRV LEMGKEVLQR ADPPKTHVTH HPISDREVTL RCWALGFYPA DISLSWQRDG EEQTQDMEFV ETRPAGDGTF QKWAALVVPP GEEQRYTCHV QHEGLPEPLT LRWEPPPWAT IPLVGLVVGL VILGAVVTGA VIWWRRNRSG GKGGSYAQAA SSDSAQGSNV SLTASNG // ID G1Q2R6_MYOLU Unreviewed; 191 AA. AC G1Q2R6; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000017999}; GN Name=LOC102422972 {ECO:0000313|Ensembl:ENSMLUP00000017999}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000017999, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000017999, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000017999} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02062677; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1Q2R6; -. DR Ensembl; ENSMLUT00000025865; ENSMLUP00000017999; ENSMLUG00000030632. DR GeneTree; ENSGT00900000141162; -. DR InParanoid; G1Q2R6; -. DR OMA; RETRICK; -. DR OrthoDB; EOG0907079Q; -. DR TreeFam; TF342059; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 191 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003419038. FT DOMAIN 26 190 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 191 AA; 21903 MW; 75A139AF7F3BAC87 CRC64; MLLTGPPTLL LLLWGALALT QTWAGPHSLR HFLTAESRPG HRKPRFVVVG YVDDTQFVRF DSDSASPRME PRAPWMEREE PGYWDVNTRN AEVAAQSFRL NLDILRGYYN QSRDGSHTFQ LMFGCEMGPD GRLVRGYDQS AYDGTDYLAL NEDLRSWTAS NTVAQITRRK WEAEGVAEER RHYLQGECLE C // ID G1Q3K3_MYOLU Unreviewed; 366 AA. AC G1Q3K3; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000018286}; GN Name=LOC102428684 {ECO:0000313|Ensembl:ENSMLUP00000018286}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000018286, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000018286, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000018286} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02057552; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000018286; -. DR Ensembl; ENSMLUT00000031279; ENSMLUP00000018286; ENSMLUG00000026691. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1Q3K3; -. DR OMA; TESWIAP; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003417929. FT TRANSMEM 309 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 40653 MW; 87AC2C37997F0826 CRC64; VPVMGSPALL LLLWGALALT QTWAGPHSLR WFSTAVSRPG RGEARYLEAG YVDDTQLEGF DSDSESQRAE PRAPWVEQEE PGYWDLSTRN AKANAQSFRV NLQTALGYYN QSRDVSHTLQ WMHGCDMGPD GRLLRGYHQS AYDGTDYIAL NEDLRSWTAA DTAAQITRRK WEEAGLAERV RNFLEGRCLE LLHRYLEMGK EVLQRADPPK THVTHHPISD REVTLRCWAL GFYPADISLS WQRDGEEQTQ DMELVETRPA GDGTFQKWAA LVVPPGEEQR YTCHVQHEGL PEPLTLRWEP PLWATIPPVG LVVGLVILGA VVTGAVVTGA VMWRRKRSDG KGGSYAQAAS SDGAQGSDVS LTASKG // ID G1Q3R9_MYOLU Unreviewed; 289 AA. AC G1Q3R9; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 20-JUN-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000018352}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000018352, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000018352, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000018352} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02000030; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1Q3R9; -. DR Ensembl; ENSMLUT00000023448; ENSMLUP00000018352; ENSMLUG00000029391. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1Q3R9; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 289 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003419084. FT DOMAIN 200 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 289 AA; 33020 MW; 3C22135C2BBF8876 CRC64; MVPVLLSLLL VVSPAVAQDT QDGPYSLSFL YTGVSRPKAD IASFQATGFI NDQPFLHYDS ESRTAEPWPW QVDGMVNWEN ETQLQQARQD IFMETLKDVM GYYRDRGNHT FKGTFGCEIR NDSYCGAFWK YAYDGRDYIK FNTEIPAWIP LQPEAVNTKV KWETEGSVQA SKDYLENECP DMLRRYLQFS RPFLDRQDPP SVSITSRVTL GLIRTLTCVA DNFYPQPISM YWTQADSVVE TESWGEGPLS ENGTYQSWVA VKIPSLDRGP YSCHVQHSSL AQPLTVTWN // ID G1Q3T6_MYOLU Unreviewed; 242 AA. AC G1Q3T6; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 20-JUN-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000018369}; DE Flags: Fragment; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000018369, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000018369} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The genome sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000018369} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02056290; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1Q3T6; -. DR Ensembl; ENSMLUT00000027025; ENSMLUP00000018369; ENSMLUG00000028336. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1Q3T6; -. DR OMA; KTHITHH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 191 214 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 95 183 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMLUP00000018369}. SQ SEQUENCE 242 AA; 26697 MW; 9A18EE77EC29B154 CRC64; GSHTIQRIVG CEMGPDGRLL RGYSQYAYDG ADYIALNEDL TSWIAADMAA QITRRKWEAE GVAELVRSYL EGTCMKFLRI YLEKGKETLQ RADPPKAHVT HHPVSALEVT LRCWALGFYP ADIRLTWQHD GEDQTQDMEL VETRPAGDGT FQKWAAVGVP PGEEQRYTCH VQHEGLPEPL TLRWEPPSHT FIFIIMGIAG GLVLLGAVAG AVMWGRRRSD GERVGSSDSA QGSDVSLSAS KG // ID G1Q4X8_MYOLU Unreviewed; 328 AA. AC G1Q4X8; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 20-JUN-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000018761}; GN Name=LOC102417991 {ECO:0000313|Ensembl:ENSMLUP00000018761}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000018761, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000018761, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000018761} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02052633; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1Q4X8; -. DR Ensembl; ENSMLUT00000026800; ENSMLUP00000018761; ENSMLUG00000028334. DR eggNOG; ENOG410IGE3; Eukaryota. DR eggNOG; ENOG41114P3; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1Q4X8; -. DR OMA; RMFGCEI; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 293 312 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 193 281 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 328 AA; 37139 MW; B55642B6E30FD312 CRC64; CVSLRQSVST GTHSLRYHYL ALSEPGPGLP QFLAVGYVND QPFIRYDSRV GRAEPQAPWI ASVDARYWET ETQKQKAWAE VQQVEMWTVM GYYNQSGAGT HSAQRMFGCE IQEDGRSSSF WQFGFDGRDH LSLDLETLSW VSAEPMAVRT KRWWESERCY AEYDKAYLEG LCLASLRRYL ELGGPSLTRR EPPTVQVTRH TIQGRGTTLR CWARGFYPQE ISLSWWLGEE ELGLETEHME TRPSGDGTYQ TWAAVWLQAG EEAGYTCRVQ HSGLNHTLTV AWATSEPAPR QEFVAVVTCA ILLVLVVGVV VFTRTRLRGR WGGIKVGG // ID G1Q4Z8_MYOLU Unreviewed; 326 AA. AC G1Q4Z8; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 20-JUN-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000018781}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000018781, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000018781} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000018781} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02025343; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1Q4Z8; -. DR Ensembl; ENSMLUT00000030190; ENSMLUP00000018781; ENSMLUG00000028263. DR GeneTree; ENSGT00920000149921; -. DR InParanoid; G1Q4Z8; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 326 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003417973. FT DOMAIN 188 277 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 326 AA; 35886 MW; 5A886C04CF5D3A08 CRC64; MRVMKSPTLL LLLSGALVLT PTWAGPTPWV FYTVVTPPGR GEPWYLAVGC MDYSQCVRFE SEGGAVGRRG RCHAWSGRTR SFGTENRGSS RDAHRISDQS EDRSHTFQVM YGCDVGPTDA YNAGRYAYDG AGYSALNQNL TSRTAAHVAA HITCDAEHPK SYLKGSRMEW LHVYLEKGKE TLQRADPPKA QGTHRPISDL EVTLRCWALG FYPADIALTW QRDGEDQTQD MELVETRPAG DGTFQKWAAS AVGIPPEEQR YTCHVQHKGL PDPLTLRRKP PSYIMGIAWG PGAGMWGRRR SGGKRGSSAQ AASNDGAQGC KVLLIK // ID G1Q5V1_MYOLU Unreviewed; 352 AA. AC G1Q5V1; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000019084}; DE Flags: Fragment; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000019084, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000019084} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000019084} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02056974; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAPE02056975; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1Q5V1; -. DR STRING; 59463.ENSMLUP00000019084; -. DR Ensembl; ENSMLUT00000030952; ENSMLUP00000019084; ENSMLUG00000030678. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1Q5V1; -. DR OMA; RMANEDW; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 352 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003418824. FT TRANSMEM 301 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMLUP00000019084}. SQ SEQUENCE 352 AA; 39411 MW; 7E746827160A8232 CRC64; LRPPALLLLL SGALVLTPSW AGPHSLRYFY TIVSRPGRGE PRYLEVGYVD DTQFVRFDSD APNPRMEPRA PWMQQPPGYW EEETLKAQGQ AQVFRVGLQT LRSYYNQSED ESHTLQRIVG CEMGPNGRLL RGYWQYAYDG ADYIALKEDL TSWTAVDIAA QITRRKWEAE GVAECDRSYL EGTCMEWLHI HTEKGKETLQ RADPPKAHVT HHPVSDREVT LRCWALGFYP ADISLTWQRD GEDQTQDMEL VETRPAGDGT FQKWAAVGVP PGEEQRYTCH VQHEGLPEPL TLRWEPPSHT FIIIMGIAGG LVLLGAVAGA VMWGRRRPGC EGVGSECASL GSDSAQGSDV SL // ID G1Q8H0_MYOLU Unreviewed; 364 AA. AC G1Q8H0; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000020003}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000020003, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000020003} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000020003} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02069335; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000020003; -. DR Ensembl; ENSMLUT00000026231; ENSMLUP00000020003; ENSMLUG00000026554. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1Q8H0; -. DR OMA; FQRMIGC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003418904. FT TRANSMEM 310 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 40864 MW; 3EA1DE1C2ABF8CDE CRC64; MRVMRPPTLL LLLSGALVLT PSWAGLHSLR YFFTAVSRPG RGEPRYLLVG YVDDTQFVRF DSDAPNPRME PRAPWMQQPW VEQERPGYWE EQTLRVKANA QTFQVDLQNL RGYYNQSEDG SHTFQRMIGC QVGPDGRLLR GYLQYAYDGA DYIALNEDLT SWTTADMAAQ ITRRNWEAVG GAELVRSYLE GECMEWLQIH LEKGKETLQR ADPPKTHVTH HPVSEREVTL RCWALGFYPA DISLTWQRDG EDQTQDMELV ETRPAGDGTF QKWAAVGVPP GEEQRYTCHV QHEGLPEPLT LRWEPPSQTF IFIIMGIAGG LVLLGAVAGA VMWGRRRETG GKGGSYAQAA SSDSGQGSDV SLSA // ID G1Q9K2_MYOLU Unreviewed; 327 AA. AC G1Q9K2; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000020385}; DE Flags: Fragment; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000020385, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000020385} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000020385} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02055906; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1Q9K2; -. DR Ensembl; ENSMLUT00000030319; ENSMLUP00000020385; ENSMLUG00000024891. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 327 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003418966. FT TRANSMEM 297 318 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMLUP00000020385}. SQ SEQUENCE 327 AA; 36977 MW; 1333027AF62BA803 CRC64; LLLLLWGALA LTQTWAGPHS LRHFLTAESR PGHRKPRFVV VSYVDDTQFV RFDSDSASPR MEPRAPWMER EEPGYWDVNT RNAEVAAQSF RLNLDILRGY YNQSRDGSHT FQLMFGCEMG PDGAWSAVMT SPPDGTDYLA LNEDLRSWTA SNTAAQITRR KWEAEGVAEE RRHYLQGECL EWLRRYLAMG KEALQRADPP KTHVTLHPIS DGEVTLRCWA LGFYPADISL SWQRDGEEQT QDTEFVETRP AGDGTFQKWA ALVVPPGEEQ RYTCHVQHEG LPEPLTLRWD WSQGSSLVVG VVIFGAVVTG AVVTGAVMRR KRSGREG // ID G1QA29_MYOLU Unreviewed; 396 AA. AC G1QA29; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000020562}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000020562, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000020562} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000020562} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02067444; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1QA29; -. DR STRING; 59463.ENSMLUP00000020562; -. DR Ensembl; ENSMLUT00000022540; ENSMLUP00000020562; ENSMLUG00000023729. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1QA29; -. DR OMA; TCVEWLC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 396 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003418984. FT TRANSMEM 310 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 396 AA; 44074 MW; B39053E9A38CEB77 CRC64; MRVLSPPTFN LLLSGALGLT PSWVGPHSLR YFSTAVSRPG RGEPRFFSVG YVDDTQFIRF YSDAASLRAE PRTPWMQQPW VEPERPGYWD RETQIFKGDA QTFRVGLNTL RGYYNQSEDG SHTLQEMYGC DVGPEGHLLR GYSQHAYDGA DYIALNEDLT SWTAANMAAQ ITKRKWEAAH WAEPVRSYLE GLCVESLLMY LDKGKETLQL ADPPKAHVTN HRVSEREVTL RCWALGFYPA DISLTWQRDG EDQTQDMELV ETRPAGDGTF QKWAAVGVPP GEEQRYTCHV QHEGLPEPLT LRWEPPSHTF IFIIMGIAGG LVLLGAVAGA VIWGRRRSGP HGPASSLVSQ GSDSTQGSDV SLSAYKGETL PWGGVGRGED WVVGSLWDTV SVKWAL // ID G1QAC6_MYOLU Unreviewed; 333 AA. AC G1QAC6; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000020659}; DE Flags: Fragment; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000020659, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000020659} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000020659} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02055906; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMLUT00000024687; ENSMLUP00000020659; ENSMLUG00000024891. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1QAC6; -. DR OMA; KTHITHY; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 2. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 30 {ECO:0000256|SAM:SignalP}. FT CHAIN 31 333 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003418199. FT TRANSMEM 301 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 204 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMLUP00000020659}. SQ SEQUENCE 333 AA; 37633 MW; 21F790E626F2C9AE CRC64; TPQTWRMLLT GPPTLLLLLW GALALTQTWA GPHSLRHFLT AESRPGHRKP RFVVVSYVDD TQFVRFDSDS ASPRMEPRAP WMEREEPGYW DVNTRNAEVA AQSFRLNLDI LRGYYNQSRD GEPRGPGPEP GLHFQVSDGT DYLALNEDLR SWTASNTAAQ ITRRKWEAEG VAEERRHYLQ GECLEWLRRY LAMGKEALQR ADPPKTHVTL HPISDGEVTL RCWALGFYPA DISLSWQRDG EEQTQDTEFV ETRPAGDGTF QKWAALVVPP GEEQRYTCHV QHEGLPEPLT LRWDWSQGSS LVVGVVIFGA VVTGAVVTGA VMRRKRSGRE GVG // ID G1QBN2_MYOLU Unreviewed; 365 AA. AC G1QBN2; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000021115}; GN Name=LOC102432715 {ECO:0000313|Ensembl:ENSMLUP00000021115}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000021115, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000021115, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000021115} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02059530; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000021115; -. DR Ensembl; ENSMLUT00000028388; ENSMLUP00000021115; ENSMLUG00000028573. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1QBN2; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003418249. FT TRANSMEM 310 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 40663 MW; 2D8DD83C65F3778D CRC64; TRVMRPPTLL LLLSGALVLT PSWAGPHSLR YFYTSVSRPG RGEPRYLEVG YVDDKQFVRF DSDAPNPRME PRAPWMQQPW VERIYPGYWD RETQISKSNA QLYRVNLQTA RGYYNQSEDG SHTIQSMRGC DLGPDGRLLR GYRQYAYDGA DYIALNEDLT SWTAADMAAQ ITKRKWEAAG VAEHWRSYLE GLCVESLLIY LEKGKETLQR ADPPKAHVTH HPVSASEVTL RCWALGFYPA DISLTWQRDG EDQTQDVELV ETRPAGDGTF QKWAAVGVPP GEEQRYTCHV QHEGLPEPLT LRWEPPSHTF IIIMGITGGL VLLGAVAGAV MWGRRRSGGK GGSYAQAASG DSSQGSDVSL SASKG // ID G1QBQ2_MYOLU Unreviewed; 357 AA. AC G1QBQ2; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 20-JUN-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000021135}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000021135, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000021135, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000021135} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02067387; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000021135; -. DR Ensembl; ENSMLUT00000030407; ENSMLUP00000021135; ENSMLUG00000026030. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1QBQ2; -. DR OMA; NTRICKA; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 357 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003419406. FT TRANSMEM 309 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 357 AA; 40451 MW; 708C5B9E83BB60BE CRC64; MRVLSPPTLL LLLSGALVLT PSWAGTHSLR YFRTAVTRPG RGEPRFFAVG YVDDTQFVRF DSDAPNPRME PRAPWMQQPW VEQVYPGYWE EETETSKTNV QNYRRNLNIL RGYYNQSEDG SHTFQCMLGC DMGPDGRLLR GYSQWAYDGA DYIALNEDLR SWTAADMAAQ ITKSKWEATR FHERRSNYLE GECLQWLRLY LEKGKETAQE TDPPKAHVTH HPVSDREVTL RCWALGFYPA DISLTWQRDG EDQTQDMELV ETRPAGDGTF QKWAAIGVPP GEEQRYTCHV QHEGLPEPLT LRWEPPPQIF IFIIMGIAGG LVLLGAVAGA VMWERRRSGG KGGSYAQAAS SDSPQGS // ID G1QBT1_MYOLU Unreviewed; 347 AA. AC G1QBT1; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000021164}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000021164, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000021164, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000021164} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02057462; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1QBT1; -. DR Ensembl; ENSMLUT00000030999; ENSMLUP00000021164; ENSMLUG00000024455. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1QBT1; -. DR OMA; TSRMKIF; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 347 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003419053. FT TRANSMEM 309 338 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 347 AA; 39098 MW; 4B6AD30E56AC5735 CRC64; VPVMGSPALL LLLWGALALT QTWAGPHSLR HFFTAVSRPG RGEARYLEVV YVDDLPVEGF DSDSESQRAE PRALWMEQVE PSIWDRSTRN AKRGAQTFRG SLHTLRGYYN QSRDGSHTIQ EMFGCEMGPD GRLLRGYDQF AYDGTDYIAL NEDLRSWTAA HTAAQITRRK WEQDGEAERF RNFLEGRCLE LLHRVLEMGK EVLQRTDPPK THVTHHPISD HEVTLRCWAL GFYPADISLS WQRDGEEQTQ DTEHVETRPA GDGTFQKWAA LVVPPGEEQR YTCHVQHEGL PEPLTLRWEP PPWATIPPVG LVVGLVILGA VVTGAVVTGA VVTGAVMWRR KRSGREG // ID G1QC77_MYOLU Unreviewed; 325 AA. AC G1QC77; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000021310}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000021310, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000021310} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000021310} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02025137; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1QC77; -. DR Ensembl; ENSMLUT00000027953; ENSMLUP00000021310; ENSMLUG00000025372. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1QC77; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 325 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003419439. FT DOMAIN 186 276 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 325 AA; 35888 MW; D589F048CE3262AE CRC64; MRVMKSPTLL LLLSGALVLT PTWAGHSLGY FYTVVSPPGR GEPGYLAVGC MDYRQCLRFE SEDGAPCVER EDPQFWDREP GKFKGSAANY RVSLDTLNQS ENRSHTYQVM YGCDVGPTDA SHAYAYDGAG YSALNQNLTS WTAAHMAAHI TCDAEHPKSY LKGSRMEWLR VYLEKGKETL QRADTPKAHG THRPISDLEV TLRCWALGFY PADIALTWQR DREDKTQDME LVESRPAGDG TFQKWAAAAV GIPPGEEQRY TCHVQHEGLP DPLTLRREPP SYIMGIAWGP GAGMWGRRRS GGKRGSSAQA ASSDGAQGCK VLLVK // ID G1QC97_MYOLU Unreviewed; 242 AA. AC G1QC97; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 20-JUN-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000021330}; DE Flags: Fragment; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000021330, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000021330} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000021330} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02056977; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1QC97; -. DR Ensembl; ENSMLUT00000024085; ENSMLUP00000021330; ENSMLUG00000022587. DR GeneTree; ENSGT00920000149921; -. DR InParanoid; G1QC97; -. DR OMA; SHEACKE; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 196 219 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 100 188 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMLUP00000021330}. SQ SEQUENCE 242 AA; 26624 MW; 5FDC17C96D3193E9 CRC64; SGSHTYQCMF GCDVGPDGRL LRGYSQWAYD GADYIALNED LTSWTVANLA AQITGRKWEA EGEAERVRSY VEGLCVESLL ISLLIYLEKG KESLQRADPP KAHVTHHPVS EREVTLRCWA LGFYPADISL TWQRDGEDQT QDMELVETRP AGDGTFQKWA AVGVPPGEEQ RYTCHVQHEG LSEPLTLRWE PPPQTFIFII MGITGGLVLL GSMAGAVMWG RRRSGGKGGS YAQAASTDCA QG // ID G1QCM8_MYOLU Unreviewed; 355 AA. AC G1QCM8; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000021461}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000021461, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000021461} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000021461} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02055906; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAPE02055907; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAPE02055908; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1QCM8; -. DR Ensembl; ENSMLUT00000024714; ENSMLUP00000021461; ENSMLUG00000023888. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1QCM8; -. DR OMA; AYLEENC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 355 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003418305. FT TRANSMEM 304 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 355 AA; 40018 MW; BDC48CF64173E08D CRC64; MGSPALLLLL WGALALTQTW AGPHSLRWFF TAVSRPGRGE ARFLEVAYVD DLPFEGFDSD SESQRAEPRA PWMEQEEPGY WDLSTRNAKR DAQIFRVNLQ TLRGYYNQSE DGSHTLQGLV GCDMGPDGRL LRGYHQSAYD GTDYLALNED LRSWTAADTA AQITRRKWEE AGEAERLRNG LEGRCLELLH RYLEMGKEVL QRADPPKTHV THHPISDREV TLRCWALGFY PADISLSWQL DGRQTQDMEF VETRLRGWDL LEWAALVVPR GEEQRYTCHV QHEGLPEPLT LRWEPPLWAT IPPVGLVVGL LWLELSGAVV TGAVMWRRKR SGGKGGSYAQ AASDDGAQGS DVSLT // ID G1QCM9_MYOLU Unreviewed; 182 AA. AC G1QCM9; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000021462}; DE Flags: Fragment; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000021462, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000021462} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The genome sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000021462} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02070595; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000021462; -. DR Ensembl; ENSMLUT00000022923; ENSMLUP00000021462; ENSMLUG00000030052. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G1QCM9; -. DR OMA; NWENEMD; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}. FT DOMAIN 25 180 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMLUP00000021462}. SQ SEQUENCE 182 AA; 20396 MW; FAE79E81DF0AA462 CRC64; VLVPSFLCSQ TPSGAISLGY DFTVTANGQP WCEIQGQVNG NTFLHYTCGS QEVKLLSVLD VNATRAWNQQ RDTLQYLVEE LKKTLLDIKA EITAPSILGT GLLSLQSSMM CEQESNGRTR ASWEFGLDGQ ISLRFDSKNR NWKVLHAEGR VLKKTLARDR SMTDLLVRTS LGDCRKWLKE VL // ID G1QEA8_MYOLU Unreviewed; 363 AA. AC G1QEA8; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 20-JUN-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000022041}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000022041, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000022041, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000022041} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02056051; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000022041; -. DR Ensembl; ENSMLUT00000022952; ENSMLUP00000022041; ENSMLUG00000024750. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1QEA8; -. DR OMA; WMEREGR; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 363 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003419540. FT TRANSMEM 309 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 363 AA; 40655 MW; B4B5C2331AF45FE2 CRC64; MPVMGSPALL LLLWGALALT QTWAGPHSLR YFFTAVSRPG RGEARYLEAG YVDDLPFEGF DSDSESQRAE PRARWMEQEE PVYWDLSTQN AKRDAQSFRR SLHTLRGYYN QSRDGSHTLQ EMWGCDMGPD GRLLRGYRQS AYDGTDYLAL NEDLRSWTAA HTAAQITRRK WEEAGEAERV RNQLEGRCLE FLHRVLAMGK EVLQRTDPPK THVTHHPISD REVTLRCWAL GFYPVDISLS WQRDGEEQTQ DTEFVETRPA GDGTFQKWAA LVVPRGEEQR YTCHVQHEGL PEPLTLRWEP PPQATIPPVG LVVGLVILGA VVTGAVVTGA VMWRRKRSGG KGGSYAQAAS SDGAQGSDVS LSA // ID G1QEF4_MYOLU Unreviewed; 366 AA. AC G1QEF4; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000022087}; GN Name=LOC102438185 {ECO:0000313|Ensembl:ENSMLUP00000022087}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000022087, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000022087, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000022087} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02056049; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000022087; -. DR Ensembl; ENSMLUT00000024941; ENSMLUP00000022087; ENSMLUG00000028684. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1QEF4; -. DR OMA; RREPWYL; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003418417. FT TRANSMEM 303 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 41001 MW; 892F9A11173E802B CRC64; MPVMGSPALL LLLWGALALT QTWASPHSLR WFSTAVSRPG RGEARFLEVA YLDDTQLERF DSDSESQRAE PRARWVEQVE PGYWDLSTRN AKATAQTFRG SLHNLRGYYN QSRDGSHTIQ WMQGCDMGPD GRLLRGYHQS AYDGTDYIAL NEDLRSWTAT STAAQITRRK WEEAGEAERF RNILEGRCLE WLRRYMAMGK EVLQRADPPK THVTHHPISD REVTLRCWAL GFYPADISLS WQRDGEEQTQ DTEFVETRPA GDGTFQKWAA LVVPPGEEQR YTCHVLHKGL PKPLTLRWEP PPWATIPLVC LVVGLVILGA VVTGAVVTGA VMWRRKRSGG KGGSYAQAAS SDGAQGSDVS LSASNR // ID G1QF12_MYOLU Unreviewed; 365 AA. AC G1QF12; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000022295}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000022295, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000022295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The genome sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000022295} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02056292; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000022295; -. DR Ensembl; ENSMLUT00000030315; ENSMLUP00000022295; ENSMLUG00000022334. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1QF12; -. DR OMA; VPGYYNQ; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003418405. FT TRANSMEM 310 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 40640 MW; 41722B3BA1E226CA CRC64; MRVMRPPTLL LLLSGALVLT PSWAGPHSLR YFRTIVSRPG RGEPRFLSVG YVDDTQFVRF DSDAPNPRAE PRAPWMQQPW VEQVYPGYWD RHTQINKNKA QIYRGNLQTL RGYYNQSEDG SHTHQYMSGC DVGPDGRLLR GYWQHAYDGA DYIALNEDLT SWTAADMAAQ ITKRKWEAAG VAEIKRSYLE GLCVESLLIY LEKGKETLQR ADPPKAHVTH HPVSESEVTL RCWALGFYPA DISLTWQRDG EDQTQDMELV ETRPAGDGTF QKWAAVGVPP GEEQRYTCHV QHEGLPEPLT LRWEPPSHTF IIIMGIAGGL VLLGAVAGAV MWGRRRSGGK GGSYAQAASS DSAQGSDVSL SPSKG // ID G1QFD1_MYOLU Unreviewed; 360 AA. AC G1QFD1; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 20-JUN-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000022414}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000022414, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000022414, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000022414} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02055907; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000022414; -. DR Ensembl; ENSMLUT00000029743; ENSMLUP00000022414; ENSMLUG00000030625. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1QFD1; -. DR OMA; HYLEEEC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 360 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003419594. FT TRANSMEM 302 325 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 360 AA; 40809 MW; 2895B47110F20DF2 CRC64; MRVMRPPTLL LLWGALALTQ TWAGPHSLRY FYTAVSRPYQ LSPRFIIVGY VDDTQFERFD SDSESQRAEP RAPWMEQEEP GYWDLSTWNA RDSAHTFRRN LLILRGYYNH SEDGSHTLQL LLGCDMGPDG RLLRGYHQYA YDGTDYIALN EDLRSWTAAD TAAQITRRKW EETGEAEERR HYLEEECMEW LRRFLEMGKE ALQRTDPPKT HVTHHPISDR EVTLRCWALG FYPADISLSW QRDGEEQTQD MELVETRPAG DGTFQKWAAL VVPPGEEQRY TCHVQHEGLP EPLTLRWEPS PWAIIHTVGL VVGLVILGAV VPGVVMCSFL STGGKGGSHA QAASSDGAQG SDVSLTASEG // ID G1QFW9_MYOLU Unreviewed; 368 AA. AC G1QFW9; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 20-JUN-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000022602}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000022602, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000022602} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The genome sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000022602} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02061493; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000022602; -. DR Ensembl; ENSMLUT00000028080; ENSMLUP00000022602; ENSMLUG00000024677. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1QFW9; -. DR OMA; DEYTHIC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 368 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003418442. FT TRANSMEM 310 335 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 41480 MW; 4C5491507DE50FB9 CRC64; MRVLRPPTLL LLLSGALVLT PSWAGPHSQR YFYTSVSRPG RGEPRFLAVG YMDDTQFLRF DSDAASPRAE PRAPWMQQPW VEQVYPGFWD RQTQKFKAAA QAYRMNLQNL RGYYNQSEDG SHTFQRMVGC DLGPDRRLLR GYEQYAYDGA DYMALNEDLT SWTAADMAAQ ITRRKWEAEG WAKHMRSYLE GLCVESLLMD LDKGKETLQR ADPPKAHVTH HRVSEREVTL RCWALGFYPA DISLTWQRDG EDQTQDMELV ETRPAGDGTF QKWAAVGVPP GEEQRYTCHV EHEGLPEPLT LRWEPPSHTV FIIIIIVGIA GSWLCWGAVA VAVMWGRRRS GGKGGSYAQA ASSDSAQGSD VSLSASRG // ID G1QGG8_MYOLU Unreviewed; 401 AA. AC G1QGG8; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000022801}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000022801, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000022801} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The genome sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000022801} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02050110; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMLUT00000028326; ENSMLUP00000022801; ENSMLUG00000028385. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1QGG8; -. DR OMA; NTENPEY; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 401 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003419279. FT TRANSMEM 345 368 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 251 335 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 401 AA; 45248 MW; FBF4925BBD7AD19A CRC64; MWTQRSHTPL LLLSGALVLS KTWAGECGSG GAASAGRRRG SDSRTPRPPP RPSLPEISHP PGPHFLSYFY TAVSRPGRGE PRFFAVGYVD DTQFVRFDSD APSPRMEPRA PWMQQPWVEQ EDPRYWDVET RNIRETAQAF RANLRNLRGY YNQSEDGSHT FQWMYGCEMG SDGSFLRGYD QFAYDGADYI ALNEDLRSWT AANEAAQLSR RRYEAVDEAE VQRNYLERVC MEWLRRYLEK GKDILQRAEP PKAHVTHHPV SAREVTLRCW ALGFYPADIS LTWQRDGEEQ IQDMELVETR PAGDGTFQKW AAVVPPGEEQ RYTCHVQHEG AEPLTLRWEP PPQTFIFIIM GIAGGLVLLG AVAGAVMWGR RRSGGKGGSY AQTARGDSSW GSDVLLKASQ G // ID G1QYD7_NOMLE Unreviewed; 396 AA. AC G1QYD7; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 28-MAR-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000005958}; OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates OS leucogenys). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hylobatidae; Nomascus. OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000005958}; RN [1] {ECO:0000313|Ensembl:ENSNLEP00000005958} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSNLEP00000005958} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Gibbon Genome Sequencing Consortium; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADFV01069168; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01069169; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1QYD7; -. DR STRING; 61853.ENSNLEP00000005958; -. DR Ensembl; ENSNLET00000006267; ENSNLEP00000005958; ENSNLEG00000004728. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1QYD7; -. DR OMA; NTRICKA; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001073; Chromosome 1a. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001073}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001073}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 331 355 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 224 312 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 396 AA; 43611 MW; 3402EDFD3CAFF88F CRC64; VPTQPPGLGV SPDAKDGVMS PRTLLLLLSG TLALAETWAG SHSLRYFSTA VSRPGRGEPR FIAVGYLEDT QFVRFDSDAA SPRMKTRARW VEQEGPEYWD LQTLGAKAQA QTDRVNLRTL LRYYNQSEAG SHILQGMFGC DVGPDGRLLR GYEQYAYDGN DYIALNEDMR SWTAADTAAQ ITQRKWEAAN VAEQRRAYLE GTCVEWLRRH LENGKETLQR ADPPKTHVTH HSVSEHEATL RCWALGFHPA EITLTWQRDG EDQTQDTELV ETRPAGDGNF QKWAAVVVPS GEEQRYMCHV QHEGLPEPLT LRWDKERDGG SCLLGKPTIP IVGIIAGLVL LGAVVTGAVV TAVMWRKKSS GGEGGRSSQS AQGSDVSLTA CKGETLGRLM CVGCWG // ID G1QYQ4_NOMLE Unreviewed; 378 AA. AC G1QYQ4; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 25-APR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000006075}; OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates OS leucogenys). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hylobatidae; Nomascus. OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000006075, ECO:0000313|Proteomes:UP000001073}; RN [1] {ECO:0000313|Ensembl:ENSNLEP00000006075} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSNLEP00000006075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Gibbon Genome Sequencing Consortium; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADFV01069168; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01069169; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSNLET00000006388; ENSNLEP00000006075; ENSNLEG00000004728. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1QYQ4; -. DR OMA; LEYWDRE; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF342059; -. DR Proteomes; UP000001073; Chromosome 1a. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001073}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001073}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 313 337 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 378 AA; 41804 MW; 815010130AC5200F CRC64; CRPAEPRGEE GRAGLSLSSP PGSHSLRYFS TAVSRPGRGE PRFIAVGYLE DTQFVRFDSD AASPRMKTRA RWVEQEGPEY WDLQTLGAKA QAQTDRVNLR TLLRYYNQSE AGSHILQGMF GCDVGPDGRL LRGYEQYAYD GNDYIALNED MRSWTAADTA AQITQRKWEA ANVAEQRRAY LEGTCVEWLR RHLENGKETL QRADPPKTHV THHSVSEHEA TLRCWALGFH PAEITLTWQR DGEDQTQDTE LVETRPAGDG NFQKWAAVVV PSGEEQRYMC HVQHEGLPEP LTLRWDKERD GGSCLLGKPT IPIVGIIAGL VLLGAVVTGA VVTAVMWRKK SSGGEGGRSS QSAQGSDVSL TACKGETLGR LMCVGCWG // ID G1QYU6_NOMLE Unreviewed; 295 AA. AC G1QYU6; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 3. DT 20-JUN-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000006117}; GN Name=LOC100592911 {ECO:0000313|Ensembl:ENSNLEP00000006117}; OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates OS leucogenys). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hylobatidae; Nomascus. OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000006117}; RN [1] {ECO:0000313|Ensembl:ENSNLEP00000006117} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSNLEP00000006117} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Gibbon Genome Sequencing Consortium; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADFV01069190; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1QYU6; -. DR STRING; 61853.ENSNLEP00000006117; -. DR Ensembl; ENSNLET00000006432; ENSNLEP00000006117; ENSNLEG00000005053. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1QYU6; -. DR OMA; EDRTHNT; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000001073; Chromosome 1a. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001073}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000001073}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 295 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014163230. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 295 AA; 33879 MW; FFB37DC34C0EFB54 CRC64; MADGTLLLLL LGALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD DTQFVRFDND AASPRMEPRA PWMEQEGPDY WDRETRSARD TAQTFRVNLR TLRGYYNQSK AGSHTLQWMH GCDLGSDGSF LRGYEQFAYD GKDYLTLNED LRSWTAVDPA AQISERKSND ACEAEHQRAY LEDTCVEWLR KYLEKGKETL LRSDPPKTHV THHHISDHEA TLRCWALGFY PAEITLTWQR DGEDRTHNTE LVETRPAGDG TFQKWTAVVV PSGEEQRYTC HVQHEGLPEP LTLRW // ID G1R2B4_NOMLE Unreviewed; 370 AA. AC G1R2B4; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 28-MAR-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000007336}; OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates OS leucogenys). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hylobatidae; Nomascus. OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000007336, ECO:0000313|Proteomes:UP000001073}; RN [1] {ECO:0000313|Ensembl:ENSNLEP00000007336} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSNLEP00000007336} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Gibbon Genome Sequencing Consortium; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADFV01069306; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 61853.ENSNLEP00000007336; -. DR Ensembl; ENSNLET00000007700; ENSNLEP00000007336; ENSNLEG00000026781. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1R2B4; -. DR OMA; VPGYYNQ; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000001073; Chromosome 1a. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001073}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001073}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 370 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014189647. FT TRANSMEM 308 330 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 370 AA; 41057 MW; 56E6CCF23DFB1820 CRC64; MRVMAHRTLL LLLSAALALT ETWAGSHSMR YFETAVSRPG RGGPGISVGY VDDTQFVRFD SDAASPREEP RAPWIEQEGP EYWDRETWRA KANAQTDQVG LRNLRGYYNQ SEDGSHTIQR MFGCYVGPDG RLLRGYLQYA YDGKDYIALN EDLSSWTAAD TAAQITQRKW EAARVAEQWR AYLEGTCVEW LRRHLENGKE TLQRADPPET HVTHHPISDH EATLRCWALG FYPAEITLTW QRDGEDQTQD TELVETRPAG DGTFQKWAAV VVPSGEEQRY TCHVQHEGLP EPVTLRWEPS SQSTITNVGI VAGLAVLAVV VTGAVVAAVM RRRKSLGHFL PTGGKGGSYS QAASSDSAQG SDVSLTACKA // ID G1R2C4_NOMLE Unreviewed; 365 AA. AC G1R2C4; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 2. DT 23-MAY-2018, entry version 47. DE SubName: Full=Major histocompatibility complex, class I, B {ECO:0000313|Ensembl:ENSNLEP00000007346}; GN Name=HLA-B {ECO:0000313|Ensembl:ENSNLEP00000007346}; OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates OS leucogenys). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hylobatidae; Nomascus. OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000007346}; RN [1] {ECO:0000313|Ensembl:ENSNLEP00000007346} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSNLEP00000007346} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Gibbon Genome Sequencing Consortium; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADFV01069309; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_003272127.2; XM_003272079.3. DR STRING; 61853.ENSNLEP00000007346; -. DR Ensembl; ENSNLET00000007710; ENSNLEP00000007346; ENSNLEG00000005839. DR GeneID; 100579523; -. DR KEGG; nle:100579523; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1R2C4; -. DR KO; K06751; -. DR OMA; MKNATQT; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000001073; Chromosome 1a. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0042270; P:protection from natural killer cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:2001198; P:regulation of dendritic cell differentiation; IEA:Ensembl. DR GO; GO:0032655; P:regulation of interleukin-12 production; IEA:Ensembl. DR GO; GO:0032675; P:regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0002667; P:regulation of T cell anergy; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001073}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001073}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003419371. FT TRANSMEM 306 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 40821 MW; 1AA135CC5E73EE09 CRC64; MRVMAPRTLL LLLSAALALT ETWAGSHSMR YFSTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKATAQTDRE NLGTLRGYYN QSEDGSHTLQ RMYGCDVGPD GRLLRGYRQD AYDGKDYLAL NEDLSSWTAA DTAAQISKRK WEAAREAEQR RPYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL REPLTKRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVAAV MWRRKSLGGK GGSYSQAASS DSAQGSDESL MACKA // ID G1RKL1_NOMLE Unreviewed; 298 AA. AC G1RKL1; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 20-JUN-2018, entry version 44. DE SubName: Full=Alpha-2-glycoprotein 1, zinc-binding {ECO:0000313|Ensembl:ENSNLEP00000013768}; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSNLEP00000013768}; OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates OS leucogenys). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hylobatidae; Nomascus. OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000013768, ECO:0000313|Proteomes:UP000001073}; RN [1] {ECO:0000313|Ensembl:ENSNLEP00000013768} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSNLEP00000013768} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Gibbon Genome Sequencing Consortium; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADFV01105258; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_003278121.1; XM_003278073.3. DR ProteinModelPortal; G1RKL1; -. DR Ensembl; ENSNLET00000014446; ENSNLEP00000013768; ENSNLEG00000011330. DR GeneID; 100595460; -. DR KEGG; nle:100595460; -. DR CTD; 563; -. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1RKL1; -. DR OMA; ILKCLAY; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001073; Chromosome 17. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001073}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000001073}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 298 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014198133. FT DOMAIN 207 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 298 AA; 34366 MW; 72ED3B6FED6D9D02 CRC64; MVRMVSVLLS LLLLLSPAVP QETQDGRYSL TYIYTGLSKP IEDVPAFQAL GLLNDLQFFS YNSRDRKSQP VGLWRQVEGM EDWKQDSQLQ KAREDIFMET LNNIMEYYND SNGSHILQGR FGCEIENNRS SGAFWKYYYD GKDYIEFNKE IPAWVPFDPA AQNTKQKWEA KPVYVQQAKA YLEEGCPETL RKYLKYSKNI LDRQDPPSVV VTSYQGPGEK KKLKCLAYDF YPGKIDMHWT RAGEVQEPEL QGNVLHDRNG TYQSWVVVAV PPQDTAPYSC HVQHSSLAQP LVVPWEAR // ID G1RZF8_NOMLE Unreviewed; 244 AA. AC G1RZF8; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000018635}; GN Name=ULBP1 {ECO:0000313|Ensembl:ENSNLEP00000018635}; OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates OS leucogenys). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hylobatidae; Nomascus. OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000018635}; RN [1] {ECO:0000313|Ensembl:ENSNLEP00000018635} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSNLEP00000018635} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Gibbon Genome Sequencing Consortium; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADFV01166529; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01166530; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_003255921.1; XM_003255873.2. DR STRING; 61853.ENSNLEP00000018635; -. DR Ensembl; ENSNLET00000019566; ENSNLEP00000018635; ENSNLEG00000015354. DR GeneID; 100603127; -. DR KEGG; nle:100603127; -. DR CTD; 80329; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G1RZF8; -. DR KO; K07986; -. DR OMA; CKMWLEE; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001073; Chromosome 3. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001073}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001073}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 244 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003420582. FT TRANSMEM 222 242 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 44 204 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 244 AA; 27972 MW; 8D6853CA823C87C3 CRC64; MAAAASPAFL LCLPLLHLLS GWSRAGRADT HCLCYDFIIT PKFRPEPQWC EVQGLVDERP FLHYDCVNHK AKAFASLGKK VNVTKTWEEQ TETLRDVVDF LKGQLLDIQV ENLIPIEPLT LQARMSCEHE AHGHGRGSWQ FLSNGHKFLL FDSNNRKWTV LHPGAKKMKE KWEKNREVIV FFQKVSMGDC KMWLEEFLTY WEQMLDPTKP PSLTPGTTEP KAMATTLSPW GLLIIFLCFI LAGR // ID G1RZG8_NOMLE Unreviewed; 243 AA. AC G1RZG8; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=UL16 binding protein 3 {ECO:0000313|Ensembl:ENSNLEP00000018645}; GN Name=ULBP3 {ECO:0000313|Ensembl:ENSNLEP00000018645}; OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates OS leucogenys). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hylobatidae; Nomascus. OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000018645}; RN [1] {ECO:0000313|Ensembl:ENSNLEP00000018645} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSNLEP00000018645} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Gibbon Genome Sequencing Consortium; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADFV01166536; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01166537; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01166538; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01166539; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_012361463.1; XM_012506009.1. DR STRING; 61853.ENSNLEP00000018645; -. DR Ensembl; ENSNLET00000019576; ENSNLEP00000018645; ENSNLEG00000015356. DR GeneID; 100603819; -. DR KEGG; nle:100603819; -. DR CTD; 79465; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G1RZG8; -. DR KO; K07986; -. DR OMA; WGKQLEM; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001073; Chromosome 3. DR GO; GO:0046658; C:anchored component of plasma membrane; IEA:Ensembl. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IEA:Ensembl. DR GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000001073}; KW Reference proteome {ECO:0000313|Proteomes:UP000001073}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 31 {ECO:0000256|SAM:SignalP}. FT CHAIN 32 243 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003421527. FT DOMAIN 31 205 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 92 112 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 243 AA; 27582 MW; 446162F1474D7B57 CRC64; MAAAASPASL LLLAILPHLL FDWSGTGRAD AHSLWYNFTI IHLPRHGQRW CEVQSQVDQK NFLSYDCGSD KILSMGHLEE QLDATDAWGK QLEMLRDVGQ RLRLELADTE KEDFPPSGPL TLQARMSCEC EADGCIRGSW QFSFDGQKFL LFDSDNGKWT AVQDGARRLK EKWEKDSGLT MFFKMVSRDC KSWLRYFLMH RKKRLEPTAP PTVAPGLAQP KAKATTLSPW SYLIILCFIL PGI // ID G1S1N4_NOMLE Unreviewed; 301 AA. AC G1S1N4; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 25-APR-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000019422}; GN Name=LOC100584223 {ECO:0000313|Ensembl:ENSNLEP00000019422}; OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates OS leucogenys). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hylobatidae; Nomascus. OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000019422, ECO:0000313|Proteomes:UP000001073}; RN [1] {ECO:0000313|Ensembl:ENSNLEP00000019422} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSNLEP00000019422} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Gibbon Genome Sequencing Consortium; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADFV01185089; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01185090; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01185091; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01185092; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01185093; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 61853.ENSNLEP00000019422; -. DR Ensembl; ENSNLET00000020404; ENSNLEP00000019422; ENSNLEG00000016013. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1S1N4; -. DR OMA; GYVDSHP; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001073; Chromosome 12. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001073}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000001073}. FT DOMAIN 172 268 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 301 AA; 34112 MW; C3CADBF9C2F1FC87 CRC64; VLFHFGTHSL RYFGLGISDP GHGVPEFISV GYVDSHLITT YDSVTRQKEP RAPWMAENLA PDHWERGTQL LRGLQQTFKV ELKRLQRHYN HSGSHTYQGM TGCELLEDGS TTGFLQYAYD GQDFLIFSKD TLSWLAVDNV ANQHELHYQR RRMYGLAKEI REYGKDTLRE QPPLVRVNRK ETFPGVTTLF CKAHGFYPPE IYMTWMKNGE EIVQEMDYGD ILPSGDGTYQ MWASVELDPQ SSNLYSCHVE HCGVHMVLQV PQESETIPLV MKAISGSIVL VIVLAGVGVL QNGAIYLPAP D // ID G1S1Q1_NOMLE Unreviewed; 308 AA. AC G1S1Q1; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 28-MAR-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000019439}; GN Name=LOC100584223 {ECO:0000313|Ensembl:ENSNLEP00000019439}; OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates OS leucogenys). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hylobatidae; Nomascus. OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000019439, ECO:0000313|Proteomes:UP000001073}; RN [1] {ECO:0000313|Ensembl:ENSNLEP00000019439} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSNLEP00000019439} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Gibbon Genome Sequencing Consortium; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADFV01185089; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01185090; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01185091; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01185092; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01185093; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1S1Q1; -. DR Ensembl; ENSNLET00000020424; ENSNLEP00000019439; ENSNLEG00000016013. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1S1Q1; -. DR OMA; EREACPR; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF342059; -. DR Proteomes; UP000001073; Chromosome 12. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001073}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000001073}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 308 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014145070. FT DOMAIN 179 275 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 308 AA; 34839 MW; E813739F6F71020F CRC64; MGELMAFLLP LIIVLMVKRS DSWTHSLRYF GLGISDPGHG VPEFISVGYV DSHLITTYDS VTRQKEPRAP WMAENLAPDH WERGTQLLRG LQQTFKVELK RLQRHYNHSG SHTYQGMTGC ELLEDGSTTG FLQYAYDGQD FLIFSKDTLS WLAVDNVANQ HELHYQRKCM AWLRRFGKPP LVRVNRKETF PGVTTLFCKA HGFYPPEIYM TWMKNGEEIV QEMDYGDILP SGDGTYQMWA SVELDPQSSN LYSCHVEHCG VHMVLQVPQE SETIPLVMKA ISGSIVLVIV LAGVGVLQNG AIYLPAPD // ID G1SI00_RABIT Unreviewed; 208 AA. AC G1SI00; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 12-SEP-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000002286}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000002286, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Genome Assembly Team; RA Lindblad-Toh K., Chang J.L., Gnerre S., Clamp M., Lander E.S.; RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Assembly Computation and Development Core Team; RA Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "Version 2 of The Genome Sequence of Oryctolagus cuniculus (European RT rabbit)."; RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSOCUP00000002286} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000002286}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [4] {ECO:0000313|Ensembl:ENSOCUP00000002286} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000002286}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9986.ENSOCUP00000002286; -. DR Ensembl; ENSOCUT00000002645; ENSOCUP00000002286; ENSOCUG00000002646. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G1SI00; -. DR OMA; NISMGDC; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001811; Unplaced. DR Bgee; ENSOCUG00000002646; Expressed in 1 organ(s), highest expression level in adult mammalian kidney. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}. FT DOMAIN 30 198 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 208 AA; 23767 MW; C4DEBFB5F03B3168 CRC64; WASIVCASFL ECPCGLHFLI TWCRSFCSDA HSLCYNITVN PKARPRQQRC DVQGHVDDRM ILHCDCSFTQ ISFFDPLGRK VDAIDNWAEQ TEMLRDVVDT LNQQVAEMKH STSKGADPPS LQGRMCCWHG ASGGRHGSWQ FSFGGQIGLL FDPNTRKWTE VHPGASWNKT TWENDRQLTE FLRKVSIGDC PRWLGKFLLP WKVMLETT // ID G1SR88_RABIT Unreviewed; 341 AA. AC G1SR88; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000005669}; GN Name=LOC100349757 {ECO:0000313|Ensembl:ENSOCUP00000005669}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000005669, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Ensembl:ENSOCUP00000005669, ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSOCUP00000005669} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000005669}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAGW02068106; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1SR88; -. DR STRING; 9986.ENSOCUP00000005669; -. DR Ensembl; ENSOCUT00000006558; ENSOCUP00000005669; ENSOCUG00000006557. DR eggNOG; ENOG410J90V; Eukaryota. DR eggNOG; ENOG41117CA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1SR88; -. DR OMA; TSRMKIF; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001811; Chromosome 12. DR Bgee; ENSOCUG00000006557; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 341 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003421571. FT TRANSMEM 308 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 341 AA; 38711 MW; 7BC80FFB2CDBFB88 CRC64; PWALVFLLLS FLRDVGAGSH SLQYFYWAVT EPSPGVPAFA ASGFVDNQRF IHYASEERKA KPCVQWLREE PSYFEDETKI FTSRMKIFQL SLRNVQQYYN QTLRPSSKPE QPHKLAGPHT LQFTYGCELQ DDGGTTGHWQ YGYDGDDYLT LDVDSRQYVA ASPLARYTKQ KWEAGQDHMQ RDVMYLTKEC ALWLHRYLEL RGANSTRTDP PKAHVTHHPA SDKEATLRCW ALGFYPAEIS LTWQRDGEDQ TQDTELVETR PGGDGTFQKW AAVVVPSGEE QRYTCRVQHE GLPEPLTLRW EPPAQPTALI VGIVAGVLGV LLILGVVVAV VRRRKHSSGR G // ID G1SRK4_RABIT Unreviewed; 241 AA. AC G1SRK4; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000005812}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000005812, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Genome Assembly Team; RA Lindblad-Toh K., Chang J.L., Gnerre S., Clamp M., Lander E.S.; RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Assembly Computation and Development Core Team; RA Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "Version 2 of The Genome Sequence of Oryctolagus cuniculus (European RT rabbit)."; RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSOCUP00000005812} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000005812}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [4] {ECO:0000313|Ensembl:ENSOCUP00000005812} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000005812}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G1SRK4; -. DR STRING; 9986.ENSOCUP00000005812; -. DR Ensembl; ENSOCUT00000006724; ENSOCUP00000005812; ENSOCUG00000006726. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G1SRK4; -. DR OMA; FLVHWEE; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001811; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}. FT DOMAIN 29 200 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 241 AA; 26717 MW; 0235D89634555CE6 CRC64; HPATVLTASA SCFPVCGVSP GWVHVGAYAH SLCYVITVNP KARPGQQRCD VQGHVDDRRI LHCDCSFTQI SFFDPLGREV DAIDNWAEQT EMLRDVVDTL IQQVAEMKHS TSKDPLSLQG RMCCQRGASG GTHGSWQFSF GGQIGLLFDP DTRKWTAVHP GASWLKTTWE NDRQLTEFLR KVSVGDCTRW LGNFLLPREE MLESTARPPT TSGPVPFKAT ATMPMPWTIL LLLTSSVLLV M // ID G1SWB1_RABIT Unreviewed; 363 AA. AC G1SWB1; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 12-SEP-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000007767}; GN Name=LOC100349247 {ECO:0000313|Ensembl:ENSOCUP00000007767}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000007767, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Ensembl:ENSOCUP00000007767, ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSOCUP00000007767} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000007767}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAGW02068108; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9986.ENSOCUP00000007767; -. DR Ensembl; ENSOCUT00000008993; ENSOCUP00000007767; ENSOCUG00000008993. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1SWB1; -. DR OMA; NTRICKA; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001811; Chromosome 12. DR Bgee; ENSOCUG00000008993; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 363 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003421790. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 363 AA; 40359 MW; B846B921EABCBBA1 CRC64; MGTLGLRPLL LLSGALVLAE TRAGSHSLQF FTTAVSRPGR GEARYITVGY VDDTPFARFD SYAENPRVEP RAPWMRQVEP GYWDRNTRFV KRSAQNYRVM LDNLRGYYNQ SEAGSHTYQS MCGCHLGPDG RLLRGYEQFA YDGADYITLN EDLRSWTAAH TAAQITQRQW EACGQAELRR SYLEGECVEW LRRYLEMGKE TLQSPVPPET RVTHHPISDQ EATLRCWALG FYPKEISLTW QQDGEDQTQD TELVETRPGG DGTFQKWAAV VVPSGEEQRY TCRVQHEGLP EPLTLTWERS SQPTALIVGT IAGLILGAVV TAAMLIAVIK RKKSSGGEGG SYTQAASSDS TQDSDGSLTA STG // ID G1T0C8_RABIT Unreviewed; 362 AA. AC G1T0C8; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000009435}; GN Name=LOC100328967 {ECO:0000313|Ensembl:ENSOCUP00000009435}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000009435, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Ensembl:ENSOCUP00000009435, ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSOCUP00000009435} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000009435}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAGW02070260; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9986.ENSOCUP00000009435; -. DR Ensembl; ENSOCUT00000010968; ENSOCUP00000009435; ENSOCUG00000010972. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1T0C8; -. DR OMA; MKNATQT; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001811; Chromosome 12. DR Bgee; ENSOCUG00000010972; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003422804. FT TRANSMEM 307 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40304 MW; 8CD97043109DB56D CRC64; MGSMAPRTLL LLLAGALTLK DTQAGSHSLR YFNIAVSRPG LGEPQYLEVG YVDDTQFVRF DSDAENPRME PRAPWMRQVE PEYWDLNTRN AKSHEQTFRV NLNTLRGYYN QSAAAGSHTI QWMYGCEVGA DGRLLRGYRQ DAYDGADYIA LNEDLRSWTA ADTAAQNTRR KWEAAGAAER QRAYLEGECV EWLRRYLEMG KETLQRADPP KAHVTHHPAS DREATLRCWA LGFYPAEISL TWQRDGEDQT QDTELVETRP GGDGTFQKWA AVVVPSGEEQ RYTCRVQHEG LPEPLTLTWE PPAQPTALIV GIVAGVLGVL LILGAVVAVV MRRKHSSDGK GGKYAPAAGG HRDQGSDDSL MP // ID G1T0D5_RABIT Unreviewed; 361 AA. AC G1T0D5; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000009445}; GN Name=LOC100355380 {ECO:0000313|Ensembl:ENSOCUP00000009445}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000009445, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Ensembl:ENSOCUP00000009445, ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSOCUP00000009445} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000009445}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAGW02068110; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1T0D5; -. DR Ensembl; ENSOCUT00000010982; ENSOCUP00000009445; ENSOCUG00000010984. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1T0D5; -. DR OMA; RITQRFY; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001811; Chromosome 12. DR Bgee; ENSOCUG00000010984; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 361 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003422641. FT TRANSMEM 304 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 361 AA; 40479 MW; ED048E98DA441F14 CRC64; MGSMAPGTLL PLLAGALTLT ETWAGSHSMR HFFTSVSRPG LGEPRFLAVG YVDDTQFARF DSDAAAAGME PRAPWMRQVE PRYWDMHRQR FEWGTLSFRE YLSNLRIYYN QSEEAGSHTI QGMYGCEVGP DGRFLRGYSI LAYDGADYLV LNEHLHSWTA VDTRPNIWKP EWDGKQCTSY LEGACVEWLR GFLEMGKETL QRVDPPKTHV AHHPISDKEA TLRCWALGFY PKEISLTWQR DGEDQTQDTE LVETRPGGDG SFQKWAAVVV PSGEEQRYTC RVQHEGLPEP LTLRWEPPAQ PTTLIVGVVA GLVLGAVVTA AVVAFVMRKR KSSVNNGRRY AESTDSKNSQ DSHMSLTAST G // ID G1T0F7_RABIT Unreviewed; 361 AA. AC G1T0F7; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 12-SEP-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000009473}; GN Name=LOC100349085 {ECO:0000313|Ensembl:ENSOCUP00000009473}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000009473, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Ensembl:ENSOCUP00000009473, ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSOCUP00000009473} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000009473}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAGW02070259; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9986.ENSOCUP00000009473; -. DR Ensembl; ENSOCUT00000011013; ENSOCUP00000009473; ENSOCUG00000011016. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1T0F7; -. DR OMA; FQRMIGC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001811; Chromosome 12. DR Bgee; ENSOCUG00000011016; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 361 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003423266. FT TRANSMEM 307 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 361 AA; 40204 MW; A8C7C0DB65B64732 CRC64; TVSMAPGTLL LLLAGALTLT QTRAGLHSMS YFYTAVSRPG LGEPRFITVG YVDDTQFSRF DSDAENPRVE PRAAWMRQVD PGYWDRETQI SKDNAQTYRV NLNTVRGYYN QSAAAGSHTF QTMFGCEVWA DGRFFRGYEQ HAYDGADYLA LNEDLRSWTA ADAAAQITQR KWESAGVAEH RRAYLEGECV EWLRRYLEMG KETLQRADPP KAHVTHHPAS DREATLRCWA LGFYPAEISL TWQRDGEDQT QDTELVETRP GGDGTFQKWA AVVVPSGEEQ RYTCRVQHEG LPEPLTLRWE PPAQPTALIV GIVAGVLGVL LILGTVAVMM RRKLSSDGKG GKYPPAAGGH RDQGSDDSLM P // ID G1T1E7_RABIT Unreviewed; 216 AA. AC G1T1E7; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 12-SEP-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000009889}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000009889, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Genome Assembly Team; RA Lindblad-Toh K., Chang J.L., Gnerre S., Clamp M., Lander E.S.; RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Assembly Computation and Development Core Team; RA Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "Version 2 of The Genome Sequence of Oryctolagus cuniculus (European RT rabbit)."; RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSOCUP00000009889} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000009889}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [4] {ECO:0000313|Ensembl:ENSOCUP00000009889} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000009889}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9986.ENSOCUP00000009889; -. DR Ensembl; ENSOCUT00000011500; ENSOCUP00000009889; ENSOCUG00000011502. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G1T1E7; -. DR OMA; DARMWAQ; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001811; Unplaced. DR Bgee; ENSOCUG00000011502; Expressed in 2 organ(s), highest expression level in prefrontal cortex. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}. FT DOMAIN 2 175 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 56 76 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 216 AA; 24274 MW; BC0E7A703742970C CRC64; DAHSLCYNIT VNPKARHGQQ RCDVQGHVDD RRILHCDCSF TKISFFDPLG REVDAIDNWA EQTEMLRDVV DALNQQVAEM KHSTSKGADP WSLQGRMCCQ CGASGGRHGS WQFSFDGQIG LLFDPDARMW AQVHPGASWM KTTWENDRQL TEFLRKVSVG DCTRWLGNFL LPREEMLEST AQPPTTSGAV PSKVTATMPM SWTFLLLLTG SVLLVR // ID G1T551_RABIT Unreviewed; 353 AA. AC G1T551; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000011447}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000011447, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Ensembl:ENSOCUP00000011447, ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSOCUP00000011447} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000011447}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAGW02070260; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1T551; -. DR STRING; 9986.ENSOCUP00000011447; -. DR Ensembl; ENSOCUT00000013302; ENSOCUP00000011447; ENSOCUG00000013304. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G1T551; -. DR OMA; RKWEALG; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001811; Chromosome 12. DR Bgee; ENSOCUG00000013304; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 15 {ECO:0000256|SAM:SignalP}. FT CHAIN 16 353 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012677783. FT TRANSMEM 304 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 353 AA; 39761 MW; 01C22899C3C2AD8E CRC64; MELRILLLMF CGALARPTTR AASHSLRYFH VAVSRPGRGE AHYTSVGFDD TQFVRFDSDA ANPRVEPLAA WMDPEGPEYW DAQTKIAGVH AQTLRSNLRT ALAYYNQSED GSHSFQWTSG CDVGPDGRFL RGYEEFAYDG ADYIVLNEDL RSWTAADMAA QITRRKWEAL GHAEHYRAYL QRECVEWLRR YLEMGKEALQ RADPPKAHVT HHPASDRKAT LRCWALGFYP AEISLTWQRD GEDQTQDTEL VETRPGGDGT FQKWAAVVVP SGEEQRYTCH VQHEGLPEPL TLTWEPPSQS TNSIVITVCL VLLGAVIAFV LWWRKSSGME RVRSDSCPTA ELRAAGGRLP VSA // ID G1T5B8_RABIT Unreviewed; 235 AA. AC G1T5B8; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 12-SEP-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000011531}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000011531, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Ensembl:ENSOCUP00000011531, ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSOCUP00000011531} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000011531}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAGW02053536; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1T5B8; -. DR STRING; 9986.ENSOCUP00000011531; -. DR Ensembl; ENSOCUT00000013401; ENSOCUP00000011531; ENSOCUG00000013406. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G1T5B8; -. DR OMA; WGKQLEM; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001811; Chromosome 12. DR Bgee; ENSOCUG00000013406; Expressed in 2 organ(s), highest expression level in adult mammalian kidney. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}. FT DOMAIN 24 195 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 78 98 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 235 AA; 26406 MW; D00510DFC827EC1E CRC64; AGGEVECESF LIPMPHSCFS STDSHSLCYN ITVNPKARPG QQRCDVQGHV DDRRILHCDC SFTKISFFDP LGREVDAIDN WAEQTEMLRD VVDALNQQVA EMKHSTSKDL QSLQGRMCCW RGASGGRHGS WQFSFDGQIG LLFDPDTRMW TEVHPGASWM KTTWENDRQL TEFLRKVSVG DCTRWLGNFL LPREEMLEST AQPPTTSGAV PSKVTATMPM SWTFLLLLTG SVLLV // ID G1T6L9_RABIT Unreviewed; 241 AA. AC G1T6L9; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 12-SEP-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000012068}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000012068, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Ensembl:ENSOCUP00000012068, ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSOCUP00000012068} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000012068}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAGW02053536; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9986.ENSOCUP00000012068; -. DR Ensembl; ENSOCUT00000014038; ENSOCUP00000012068; ENSOCUG00000025994. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G1T6L9; -. DR OMA; MKEDEND; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001811; Chromosome 12. DR Bgee; ENSOCUG00000025994; Expressed in 1 organ(s), highest expression level in adult mammalian kidney. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}. FT DOMAIN 29 200 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 241 AA; 26896 MW; 95B99B3090254686 CRC64; HPATVLTASA SCFPVCGVSP GWVHIGAYSH SLCYVITVNP KAGPRQQRCD VQGHVDDRRI LHYDCSFTKI SFFDPLGREV DAIDNWAEQT EMLRDVVDTL IQQVAEMKHS TSKDPLSLQG RMCCWRGASG GTHGSWQFSF GGQIGLLFDP DARMWTEVHP GASWLKTTWE NDRQLTEFLR KVSVGDCTRW LGNFLLPREE MLESTARPPT TSGPVPFKAT ATMPMPWTIL LLLTSSVLLV M // ID G1T6T1_RABIT Unreviewed; 857 AA. AC G1T6T1; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 2. DT 12-SEP-2018, entry version 49. DE SubName: Full=TRIM39-RPP21 readthrough {ECO:0000313|Ensembl:ENSOCUP00000012153}; GN Name=TRIM39-RPP21 {ECO:0000313|Ensembl:ENSOCUP00000012153}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000012153, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Ensembl:ENSOCUP00000012153, ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSOCUP00000012153} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000012153}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAGW02068107; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9986.ENSOCUP00000012153; -. DR Ensembl; ENSOCUT00000014141; ENSOCUP00000012153; ENSOCUG00000014141. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118893; -. DR InParanoid; G1T6T1; -. DR OrthoDB; EOG091G05W2; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001811; Chromosome 12. DR Bgee; ENSOCUG00000014141; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005622; C:intracellular; IEA:InterPro. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR CDD; cd00021; BBOX; 1. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR001870; B30.2/SPRY. DR InterPro; IPR003879; Butyrophylin_SPRY. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR InterPro; IPR006574; PRY. DR InterPro; IPR007175; Rpr2. DR InterPro; IPR000315; Znf_B-box. DR InterPro; IPR001841; Znf_RING. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR InterPro; IPR017907; Znf_RING_CS. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR Pfam; PF13765; PRY; 1. DR Pfam; PF04032; Rpr2; 1. DR Pfam; PF00643; zf-B_box; 1. DR PRINTS; PR01407; BUTYPHLNCDUF. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00336; BBOX; 1. DR SMART; SM00407; IGc1; 1. DR SMART; SM00589; PRY; 1. DR SMART; SM00184; RING; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF49899; SSF49899; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50188; B302_SPRY; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. DR PROSITE; PS50119; ZF_BBOX; 1. DR PROSITE; PS00518; ZF_RING_1; 1. DR PROSITE; PS50089; ZF_RING_2; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175, KW ECO:0000256|SAAS:SAAS00139444}; MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175, KW ECO:0000256|SAAS:SAAS00139444}; KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175, KW ECO:0000256|SAAS:SAAS00139444}. FT TRANSMEM 799 822 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 29 70 RING-type. {ECO:0000259|PROSITE:PS50089}. FT DOMAIN 102 143 B box-type. FT {ECO:0000259|PROSITE:PS50119}. FT DOMAIN 289 512 B30.2/SPRY. FT {ECO:0000259|PROSITE:PS50188}. FT DOMAIN 702 790 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 190 221 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 857 AA; 97500 MW; 965107547B00D51B CRC64; MAETSLLEAG TSAASTAAAL ENLQVEASCS VCLEYLKDPV IIECGHNFCK ACITRWWEDL ERDFPCPVCR KTSRYRSLRP NRQLGSMVEI AKQLQAVKRK IRDESLCPQH HEALSLFCYE DQEAVCLICA ISHTHRAHTV VPLDDATQEY KEKLQKCLEP LEQKLQEITR CKSSEEKKPG ELKRLVESRR QQILREFEEL HRRLDEEQQM LFARLEEEEQ DILQRLRENA AHLGDKRRDL AHLAAEVEGK CLQSGFEMLK DVKNTLEKCE KVKTMEVTSV SIELEKNFSN FPRQYFALRK ILKQLIADVT LDPETAHPNL VLSEDRKSVK FVETRLRDLP DTPRRFTFYP CVLATEGFTS GRHYWEVEAA HCVLAQDPEN QALARFYCHT ERTIAKRLVL RRDPSVKRTL CRGCSSPLIP GLTCTQRQRR CKGQRWTVQT CLTCQRSQRF LNDPRHLLWG DRPEAQLGSQ AEEPIGTAGL KSPRRDGDCL YREYGTMECG ALLLLLAGAL TLTETRTGSH SLRYFTTAVS RPGLPEPRFM SVGYVDDTQF VRFDSDAASP RAEPRAPWMQ QVEPWYWDRQ TERAKNTALS FRVNLQTLRG YYNQSDTGSH TLQWMYGCEV GADGRLLRGY EQFAYDGADY IALNEDLRSW TAADTAAQIS KRKSEEASEA ERHRSYLEGE CVEWLRRYLQ DGKETLQRAD PPKAHVTHHP ASDKEATLRC WALGFYPAEI SLTWQRDGED QTQDTELVET RPGGDGTFQK WAAVVVPSGE EQRYTCRVQH EGLPEPLTLR WEPPAQPTAL IVGIVAGVHG VLLILGAVVA VVMRRKLSSD GKGGKYAPAA GGHRDQGSDD SLLSVKP // ID G1T7D7_RABIT Unreviewed; 348 AA. AC G1T7D7; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 2. DT 12-SEP-2018, entry version 53. DE SubName: Full=Hemochromatosis {ECO:0000313|Ensembl:ENSOCUP00000012404}; GN Name=HFE {ECO:0000313|Ensembl:ENSOCUP00000012404}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000012404, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Ensembl:ENSOCUP00000012404, ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSOCUP00000012404} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000012404}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAGW02052081; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_002714258.1; XM_002714212.3. DR ProteinModelPortal; G1T7D7; -. DR STRING; 9986.ENSOCUP00000012404; -. DR Ensembl; ENSOCUT00000014427; ENSOCUP00000012404; ENSOCUG00000014424. DR GeneID; 100347987; -. DR KEGG; ocu:100347987; -. DR CTD; 3077; -. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1T7D7; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001811; Chromosome 12. DR Bgee; ENSOCUG00000014424; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl. DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:Ensembl. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl. DR GO; GO:0030881; F:beta-2-microglobulin binding; IEA:Ensembl. DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl. DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0071281; P:cellular response to iron ion; IEA:Ensembl. DR GO; GO:0042446; P:hormone biosynthetic process; IEA:Ensembl. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:Ensembl. DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IEA:Ensembl. DR GO; GO:1904283; P:negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:Ensembl. DR GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; IEA:Ensembl. DR GO; GO:1900121; P:negative regulation of receptor binding; IEA:Ensembl. DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; IEA:Ensembl. DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR GO; GO:1904434; P:positive regulation of ferrous iron binding; IEA:Ensembl. DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl. DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl. DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IEA:Ensembl. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; IEA:Ensembl. DR GO; GO:1900390; P:regulation of iron ion import; IEA:Ensembl. DR GO; GO:2000008; P:regulation of protein localization to cell surface; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 348 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003422221. FT TRANSMEM 305 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 348 AA; 39526 MW; 1C9D5E863C13F0A4 CRC64; MRPRAQPALL LLLFVRAVVP QARPPRSHSL LYLFMGASQP DLGLPLFEAL GYLDDQLFVS YDHESRRAEP RAPWLQGGTS SQLWLQLSQS LKGWDHMFTV DFWTIMDNHN HSQGSHTLQV ILGCEVREDN STRGFWKYGY DGQDHLEFCP ETLDWKAAEP GAQATKLEWE VHKIRAKQNK VYLERDCPEQ LQQLLEVGRG TLDQQVAPSV TVTRHMSSAT TTLRCRALHF YPPNITMQWL KDRQPLEAKD VELRTMLPNG DGTYQARVAL TVPYGEEQRF TCWVEHPGLD QPIAATWEPS LSSSLVIGIA SGITVCVLTI FFGILYQIFK KRQASRGALG DYVLAECQ // ID G1TJN3_RABIT Unreviewed; 244 AA. AC G1TJN3; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 12-SEP-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000017162}; GN Name=LOC103347295 {ECO:0000313|Ensembl:ENSOCUP00000017162}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000017162, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Genome Assembly Team; RA Lindblad-Toh K., Chang J.L., Gnerre S., Clamp M., Lander E.S.; RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Assembly Computation and Development Core Team; RA Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "Version 2 of The Genome Sequence of Oryctolagus cuniculus (European RT rabbit)."; RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSOCUP00000017162} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000017162}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [4] {ECO:0000313|Ensembl:ENSOCUP00000017162} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000017162}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G1TJN3; -. DR STRING; 9986.ENSOCUP00000017162; -. DR Ensembl; ENSOCUT00000031144; ENSOCUP00000017162; ENSOCUG00000025408. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G1TJN3; -. DR OMA; ISASWEF; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001811; Unplaced. DR Bgee; ENSOCUG00000025408; Expressed in 2 organ(s), highest expression level in adult mammalian kidney. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}. FT DOMAIN 55 198 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 244 AA; 27597 MW; 53331B7E76B617D4 CRC64; WASIVCASFL ECPCGLHFLI TWCRSFCSDA HSLCYNITVN PKARPRQQRC DVQVHVDDRM ILHCDCSFTQ ISFFDPLGRK VDAIDNWAEQ TEMLRDVVDT LNQQVVEMKH STSKGADPPS LQGRMCCWCG ASGGRHGSWQ FSFDGQIGLL LDPNARKWTE VHPGASWNKT TWENDRQLTE FLRKVSIGDC PRWLGKFLLP WKVMLETTAW PPTTLGVVAS KATATMPMPW AFFLLLTSSV LLVV // ID G1TM84_RABIT Unreviewed; 243 AA. AC G1TM84; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 12-SEP-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000018092}; GN Name=LOC100357076 {ECO:0000313|Ensembl:ENSOCUP00000018092}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000018092, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Ensembl:ENSOCUP00000018092, ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSOCUP00000018092} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000018092}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAGW02053233; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1TM84; -. DR STRING; 9986.ENSOCUP00000018092; -. DR Ensembl; ENSOCUT00000023163; ENSOCUP00000018092; ENSOCUG00000024780. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G1TM84; -. DR OMA; CKMWLEE; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001811; Chromosome 12. DR Bgee; ENSOCUG00000024780; Expressed in 3 organ(s), highest expression level in liver. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}. FT DOMAIN 30 194 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 83 103 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 243 AA; 26779 MW; 4FCB9BEB670E0E79 CRC64; AAKAGSDFLR PSPALQLGSL VSELGERDGH SLCYNITVNP KAGPGQQRCD VQGHVDDRRI LHCDCSFTQI SFFDPLGRDV DAIENWAEQT EVLRDVVDAL NQQVAEMQHS TSKGADPPSL QGRMCCRRGA SGGTHGSWQF SFDGQIGLLF APDTRKWTEV HPGASWMKTT WENDRQLTEF LRRVSMGDCT RWLGDFSLSW EEMPEATAWP PTTSGAVPSK ATATMPLPWT FLLLLTGSVL LVV // ID G1TMD5_RABIT Unreviewed; 349 AA. AC G1TMD5; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 2. DT 12-SEP-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000018144}; GN Name=LOC100354611 {ECO:0000313|Ensembl:ENSOCUP00000018144}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000018144, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Ensembl:ENSOCUP00000018144, ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSOCUP00000018144} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000018144}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAGW02043964; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_008260234.1; XM_008262012.2. DR ProteinModelPortal; G1TMD5; -. DR Ensembl; ENSOCUT00000028639; ENSOCUP00000018144; ENSOCUG00000023680. DR GeneID; 100354611; -. DR eggNOG; ENOG410IGE3; Eukaryota. DR eggNOG; ENOG41114P3; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1TMD5; -. DR OMA; RMFGCEI; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001811; Chromosome 11. DR Bgee; ENSOCUG00000023680; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 294 316 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 198 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 349 AA; 39909 MW; 05C2C6890CC4DFCE CRC64; MAELASLKLE NKPWPGGTHS LHYHYLALSE PGPSLPEFLA VGYVDDQPFI RYDSRTGRAE LRAAWMAPVD TQYWETETQK QKAWEKVQQV EMWTVMGYHN QSSGTHTAQR MFGCEVQEDG SSSSFWQFGF DGQDHLSLDV ETLSWVSAEP VAVRTKRWWE TERCYAEYDK AYLEGLCLTS LHRYLELGSQ SLTRKEPPMV HITKHMTQDG TTLRCWALGF YPQDISLNWW LDGEELTLET EHVETRPSGD GTYQTWVAVQ VPAGKEAWYS CHVRHPGLNH TLTVAWESPS NSGLIAMAIS TVLITIMLIA VTVIWSKRCL QAWNKKSYVQ TPAPGAGFQK EEQYYKQLC // ID G1TN25_RABIT Unreviewed; 310 AA. AC G1TN25; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 2. DT 12-SEP-2018, entry version 53. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000018393}; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSOCUP00000018393}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000018393, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Genome Assembly Team; RA Lindblad-Toh K., Chang J.L., Gnerre S., Clamp M., Lander E.S.; RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Assembly Computation and Development Core Team; RA Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "Version 2 of The Genome Sequence of Oryctolagus cuniculus (European RT rabbit)."; RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSOCUP00000018393} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000018393}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [4] {ECO:0000313|Ensembl:ENSOCUP00000018393} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000018393}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR RefSeq; XP_002721920.1; XM_002721874.3. DR ProteinModelPortal; G1TN25; -. DR STRING; 9986.ENSOCUP00000018393; -. DR Ensembl; ENSOCUT00000021347; ENSOCUP00000018393; ENSOCUG00000027203. DR GeneID; 100349289; -. DR KEGG; ocu:100349289; -. DR CTD; 563; -. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1TN25; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001811; Unplaced. DR Bgee; ENSOCUG00000027203; Expressed in 3 organ(s), highest expression level in liver. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 310 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003422784. FT DOMAIN 204 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 310 AA; 35411 MW; 6F06ED22615CE9A5 CRC64; MVPVLLSLPL LLGSTVPQGT QAGPYLLTFL YTGLSRPSKG FPRFQATAFL NDQAFFHYDS ESRKAEPLGP WSQVEGMEDW KKESQLQQAR EEIFLETLKD AMNYYKESTG SHTFQGMFGC ELQNNRSSGA FWRYAYDGED FIEFNKEVPA WVALDPAALN TKKKWEAEKV YVQRAKAYLE EECPGMLQRY LNYSRTHLDR QEPPSVTASS HMAPGQNRTL KCLAYDFYPQ GIGLHWTRAG EMQKLELERH ILPSGKGTYL SWVVVGVPSQ DRAPYSCHVE HRSLAQPLTL LWDERQTASA EDKVETPRPQ // ID G1TQ15_RABIT Unreviewed; 229 AA. AC G1TQ15; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 12-SEP-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000019105}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000019105, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Genome Assembly Team; RA Lindblad-Toh K., Chang J.L., Gnerre S., Clamp M., Lander E.S.; RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Assembly Computation and Development Core Team; RA Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "Version 2 of The Genome Sequence of Oryctolagus cuniculus (European RT rabbit)."; RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSOCUP00000019105} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000019105}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [4] {ECO:0000313|Ensembl:ENSOCUP00000019105} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000019105}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G1TQ15; -. DR STRING; 9986.ENSOCUP00000019105; -. DR Ensembl; ENSOCUT00000022017; ENSOCUP00000019105; ENSOCUG00000023967. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G1TQ15; -. DR OMA; QIAKRPL; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001811; Unplaced. DR Bgee; ENSOCUG00000023967; Expressed in 1 organ(s), highest expression level in adult mammalian kidney. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}. FT DOMAIN 24 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 78 98 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 229 AA; 25609 MW; 13B9F4CB46681488 CRC64; AGGEVECEPF LIPTPHLCFS STDAHSLCYV ITVNPKARPG QQRCDVQGHV DDRRILHCDC SFTQISFFDP LGREVDAIDN WAEQTEMLRD VVDALNQQVA EMKHSTSKAN VFPMGADARS LQGRMCCWRG DSGGRHGSWQ FSFDGKIGLL FDPDARKWTE VHPGASWLKT TWENDRQLTE FLRKVSVGDC TRWLGNFLLP REEMLESTEP SPMPAPASLP GATPGRSAW // ID G1TUV2_RABIT Unreviewed; 263 AA. AC G1TUV2; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000020828}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000020828, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Genome Assembly Team; RA Lindblad-Toh K., Chang J.L., Gnerre S., Clamp M., Lander E.S.; RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Assembly Computation and Development Core Team; RA Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "Version 2 of The Genome Sequence of Oryctolagus cuniculus (European RT rabbit)."; RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSOCUP00000020828} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000020828}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [4] {ECO:0000313|Ensembl:ENSOCUP00000020828} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000020828}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G1TUV2; -. DR STRING; 9986.ENSOCUP00000020828; -. DR Ensembl; ENSOCUT00000023386; ENSOCUP00000020828; ENSOCUG00000022884. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G1TUV2; -. DR OMA; GNETHIP; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001811; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 32 {ECO:0000256|SAM:SignalP}. FT CHAIN 33 263 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003423667. FT TRANSMEM 229 248 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 32 204 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 263 AA; 29226 MW; 309DD4CC607350A5 CRC64; SRRCELTSGP ALLCTAVLVF LLPLRMHVGL DAHSLCYVIT VNPKARPGQQ RCDVQGHVDD KRILHCDCSF TQISFFDPLG REVDAIDNWA EQTDMLRDVV DTLIQQVAEM KHSTNGADPL SLQGRMCCQR GASGGTHGSW QFSFGGQIGL LFDPDTRKWT EVHPGASWLK TTWENDRQLT EFLRKVSVGD CTRWLGSFLL PREEMLESTA RPPTTSGPVP FKATATMPMP WTILLLLTSS VLLVMIGWDD GRALLGLWGL LTS // ID G1U4Y5_RABIT Unreviewed; 359 AA. AC G1U4Y5; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 12-SEP-2018, entry version 45. DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSOCUP00000024461}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSOCUP00000024461}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000024461, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Genome Assembly Team; RA Lindblad-Toh K., Chang J.L., Gnerre S., Clamp M., Lander E.S.; RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Assembly Computation and Development Core Team; RA Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "Version 2 of The Genome Sequence of Oryctolagus cuniculus (European RT rabbit)."; RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSOCUP00000024461} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000024461}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [4] {ECO:0000313|Ensembl:ENSOCUP00000024461} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000024461}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9986.ENSOCUP00000024461; -. DR Ensembl; ENSOCUT00000021967; ENSOCUP00000024461; ENSOCUG00000024751. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G1U4Y5; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001811; Unplaced. DR Bgee; ENSOCUG00000024751; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019864; F:IgG binding; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 359 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003423988. FT DOMAIN 201 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 39301 MW; 4D873FB9E1FB082D CRC64; MGRPRLLPGA LRLLLCLLPG TLAAGSHLSL LYHITAVTDP HGGTPSFFVS GWLGPQQYLS YSNRRSEAEP YGAWIWESQV SWYWEKETVD LKNKQQLFLE ALEVLGEGSY TLQGLLGCEL GPDNASVPTA KFALNGEDFM SFDPKQGSWA GEWPEALRIS TRWQQQAEAV SKERTFLLTS CPQRLLGHLE RGRGNLEWKE PPSMRLKARP GSPGFSVLTC SAFSFYPPEL QFGFLRNGMA AGSGEGGFGP NGDGSFYAWA SLSVRSGDEY RYSCVVRHAG LPQPLSVALV GHAQSSVTVA GIFTVRLLIS SIQLGGLMPY GSRRSLRNAP WVFLRGDDIR TLLPQDEGPQ DVSAFPATA // ID G1U736_RABIT Unreviewed; 210 AA. AC G1U736; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 12-SEP-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000025236}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000025236, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Genome Assembly Team; RA Lindblad-Toh K., Chang J.L., Gnerre S., Clamp M., Lander E.S.; RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Assembly Computation and Development Core Team; RA Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "Version 2 of The Genome Sequence of Oryctolagus cuniculus (European RT rabbit)."; RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSOCUP00000025236} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000025236}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [4] {ECO:0000313|Ensembl:ENSOCUP00000025236} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000025236}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G1U736; -. DR STRING; 9986.ENSOCUP00000025236; -. DR Ensembl; ENSOCUT00000023523; ENSOCUP00000025236; ENSOCUG00000021528. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G1U736; -. DR OMA; EANGHTH; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001811; Unplaced. DR Bgee; ENSOCUG00000021528; Expressed in 2 organ(s), highest expression level in adult mammalian kidney. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}. FT DOMAIN 2 172 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 56 76 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 210 AA; 23525 MW; 6B2FC35C1BCBD65E CRC64; DAHSLCYNIT VNPKARPGQQ RCDVQGHVDD RRILHCDCSF TKISFFDPLG REVDAIDNWA EQTEMLRDVV DALNQQVAEM KRSTSKDPLS LQGRMCCWRG ASGGRHGSWQ FSFDGQIGLL FDLDARMWTE VHPGASWLKT TWNDRQLTEF LRKVSVGDCT RWLGNFLLPR EEMLESTVEC PAPPSESPAP SPGTLSVVIS CCFCLCALGV // ID G1U8R4_RABIT Unreviewed; 357 AA. AC G1U8R4; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 12-SEP-2018, entry version 45. DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSOCUP00000025831}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSOCUP00000025831}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000025831, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Genome Assembly Team; RA Lindblad-Toh K., Chang J.L., Gnerre S., Clamp M., Lander E.S.; RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811}; RG The Genome Sequencing Platform; RG The Assembly Computation and Development Core Team; RA Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "Version 2 of The Genome Sequence of Oryctolagus cuniculus (European RT rabbit)."; RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSOCUP00000025831} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000025831}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [4] {ECO:0000313|Ensembl:ENSOCUP00000025831} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000025831}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSOCUT00000025974; ENSOCUP00000025831; ENSOCUG00000024751. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000001811; Unplaced. DR Bgee; ENSOCUG00000024751; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 357 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003424666. FT DOMAIN 201 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 357 AA; 39190 MW; 912C44417D26440A CRC64; MGRPRLLPGA LRLLLCLLPG TLAAGSHLSL LYHITAVTDP HGGTPSFFVS GWLGPQQYLS YSNRRSEAEP YGAWIWESQV SWYWEKETVD LKNKQQLFLE ALEVLGEGSY TLQGLLGCEL GPDNASVPTA KFALNGEDFM SFDPKQGSWA GEWPEALRIS TRWQQQAEAV SKERTFLLTS CPQRLLGHLE RGRGNLEWKE PPSMRLKARP GSPGFSVLTC SAFSFYPPEL QFGFLRNGMA AGSGEGGFGP NGDGSFYAWA SLSVRSGDEY RYSCVVRHAG LPQPLSVALG WPSSPRPAAH GLLPADALWL SALSAQCLRH RRLTSLPPWV FLRGDDIRTL LPQDEGPQDV SAFPATA // ID G3HDU0_CRIGR Unreviewed; 306 AA. AC G3HDU0; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 23-MAY-2018, entry version 36. DE SubName: Full=Hereditary hemochromatosis protein-like {ECO:0000313|EMBL:EGV94287.1}; GN ORFNames=I79_008706 {ECO:0000313|EMBL:EGV94287.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV94287.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH000302; EGV94287.1; -; Genomic_DNA. DR ProteinModelPortal; G3HDU0; -. DR PRIDE; G3HDU0; -. DR InParanoid; G3HDU0; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 263 287 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 166 245 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 306 AA; 35093 MW; 549DD30444F4ED15 CRC64; MGYVDDQLFV SYNHENRRAE PRAPWILDQT SSQLWLQLSQ SLKGWDHMFI VDFWNIMDNY NHSKGSKLGV MPESHILQVI LGCEVHEDNS TSGIWKYGYD GQDHLEFCPT TLEWRAAEPG AWTTKVEWEE HKIRTRQNKD YLERDCPEQL KQFLELGSGL LKQQVPPLVK VTHHWAPAGT SLRCQALNFF PQNITMKWLK DNQPLDVNDI NPKDVLPNGD GTYQAHMTLP VAPGDETRFT CQVEHPGLDQ PLIATWEPLP SRAMIIGTIS GITICVIFFV GILFLILRKR KASEETMGDY VLAECE // ID G3HQN2_CRIGR Unreviewed; 247 AA. AC G3HQN2; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 23. DE SubName: Full=RT1 class I histocompatibility antigen, AA alpha chain {ECO:0000313|EMBL:EGW09061.1}; GN ORFNames=I79_013137 {ECO:0000313|EMBL:EGW09061.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW09061.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH000617; EGW09061.1; -; Genomic_DNA. DR ProteinModelPortal; G3HQN2; -. DR InParanoid; G3HQN2; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 247 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003444530. FT TRANSMEM 215 238 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 24 202 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 247 AA; 28127 MW; 4E1301998F51CB7A CRC64; MGSPLLWDLL LLVASQALTQ TRAGSHSLLY FRTIVSRPGL GEPRFIAVGY VDDTQFVRFD SDAESLRYEP LTTWAKREGL EHWERQTRFV KISEQIYRGN LRTLLDYYNQ SEGGSHSIQV MYGCDMGSDG RLLRGYRQDA YDGRDYIALN EDLRTWTPAD RAAQITRRKW EQTGFAENEK AYVEGTCLEW LRRYLENGKD QLLRTEPPPQ STVPIMAVIA VLVLLESVAI IGAVVAVVDN EGTMLQL // ID G3HQN3_CRIGR Unreviewed; 789 AA. AC G3HQN3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 23-MAY-2018, entry version 36. DE SubName: Full=H-2 class I histocompatibility antigen, D-D alpha chain {ECO:0000313|EMBL:EGW09062.1}; GN ORFNames=I79_013138 {ECO:0000313|EMBL:EGW09062.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW09062.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH000617; EGW09062.1; -; Genomic_DNA. DR PRIDE; G3HQN3; -. DR InParanoid; G3HQN3; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.30.500.10; -; 3. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 3. DR Pfam; PF00129; MHC_I; 3. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 3. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS00290; IG_MHC; 3. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 789 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003444379. FT TRANSMEM 559 581 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 701 725 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 461 539 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 618 692 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 789 AA; 89001 MW; EA01A4B72AC24401 CRC64; MRIPVLCALL WLAAILGLAQ TGAGSHSLRY FYTIESRPSL REPRFIAVGY VDDTQFVRFD SDAENPRYEP RAQWMEREEP EYWERETRKA KELEQSFRGK LRTLLGYYNQ NKGGSHTFQH LSGCHLGSNG RFQRGYEQFA YDGNDYIALN DDLRTWTAAD PEAQMAWRKW EQTGEAERHR AYLEGECVEW LHRHLEHGKD QLLRTDPPKT HVTHHPKPDG KVTLRCWALG FYPADITLTW NKDEEELTQD MEIVETRPAG DGTFQKWAAV EVPVGEEQNY TCFVEHEGLP EPLTLRWGSH SLRYFHTAVS RPGLGEPRYI EVGYVDDTQF VRFDSDAETP RMEPRAPWME EGPGEGAGVL GEGDTESSHT IQRLAGCEVG SDRRLLRGYS QDAYDGRDYI ALNEDLRTWT AADTMALITR GKLEQNGIAE RLRDYLEGEC VEWLRRYLEK GKDQLLRKDP PKAHVTHHPR SQGDVTLRCW ALDFYPADIS LTWQREEEEQ AQEMELVETR PAGDGNFQKW ASLVVPSGEE QKYTCHVYHE GLPEPLILRW EPPQSTVPIM AVIAVLVLLG AVTIIGAVVV VRKRMRNSGG KGGNYALALG RDSAQSSDLS LEAGKGDVTL RCWAMGFYPA DITLTWKREE EEQTQDMELV ETRPSGDGTF QKWAAVEVPI GEEQKYTCHV YHEGLPEPLT LRWEPPPQST VPIMAVIAAL VLLGAVIIGP VVALVRKKGS GEKGGKYAPG LDCKGDTLGP DLGWGGRKLN MIGLQGLPES PVSEWCGGLF GCCLHSDCS // ID G3HQR3_CRIGR Unreviewed; 213 AA. AC G3HQR3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EGW09092.1}; GN ORFNames=I79_013169 {ECO:0000313|EMBL:EGW09092.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW09092.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH000617; EGW09092.1; -; Genomic_DNA. DR ProteinModelPortal; G3HQR3; -. DR PRIDE; G3HQR3; -. DR InParanoid; G3HQR3; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}. FT DOMAIN 103 191 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 213 AA; 24608 MW; 69817557EE44DE47 CRC64; MLVLGAVLGP HTLQFTYGCQ IRDDRSTTGH WQYGYDGSDY LALDLDSMQY VAATFIAGYT KRKWEHSEYW LERDSSYLKT ECILWLHRYL ALGGENFNRT DPPQTRVTHH PRPEGDATLR CWALGFYPAE ISLTWQLDTE ELTQDMELVE TRPSGDGTFQ KWAAVVVPSG EEQKYTCHVH HEGLPEPLTL RWGKERVGAQ SWAQGKQKPF WRP // ID G3HQR5_CRIGR Unreviewed; 797 AA. AC G3HQR5; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 23-MAY-2018, entry version 33. DE SubName: Full=H-2 class I histocompatibility antigen, D-37 alpha chain {ECO:0000313|EMBL:EGW09094.1}; GN ORFNames=I79_013171 {ECO:0000313|EMBL:EGW09094.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW09094.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH000617; EGW09094.1; -; Genomic_DNA. DR PRIDE; G3HQR5; -. DR InParanoid; G3HQR5; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 3. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 2. DR Pfam; PF00129; MHC_I; 3. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 2. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 3. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS00290; IG_MHC; 2. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 797 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003444573. FT TRANSMEM 204 229 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 699 724 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 117 195 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 602 688 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 797 AA; 90452 MW; 9E738A79B9C9990F CRC64; MGAVAPRTLL LLLAAALAPT QTRAAGPSRP VPTRVPSPAP ARPGFGEPRY LKVGYVDDVQ FVRFDSDAEN PRMEPRAPWV EREGPEYWEG ETQRAKNREQ IFRGNLRTLM GYYNQSEGDD VTLRCWAMGF YPAVITLTWQ REEEEQTQDM ELVETRPSGD GTFQKWAAVV VPSGEEQKYT CHVYHEGLPE PLTLRWEPPP QSTVLIMAVI AVLVLLGVVT IIGAVVFFVR KRRNSGGKGG KYAPAPGSHS LLYFYTTVSR PGLGDPRFIF VGYVDDTQFV RFDSDAETPR VEPCVGWMEQ ERPEYWELQT QMAWTQAKLS GGSLMTLLRY FNQSKDDSHT LQGMRGCDVG ADGRLLHGYN QLGYDGEDYL TLNEDLSSWT ATLGQISQGK LGDHLKDSCV ETLHKHLEKG KEVLLRSGSH SLRYFSTIVS RPGLGEPRFI YVGYVDDRQI VRYDSDAENP RMEPRAPWME REGPGYWERE TRKAKDTGKN FRSNLKTLLG YYNQSDDEPH TLQWMYGCDV GPDGRLLRGY CQEAYDGHDY ISLNEDLRSW TANDLASQIS KQKSENVDEA HHQRAYLQGP CIEWLLKYLE LGKSTLLLSD PPKAYVTHHP GYKGDVTLRC WAMGFYPADI TLTWQREEEE QTQDRELVET RPSGDGTFQK WAAVVVPSGE EQKYTCHVHH ERLPEPLTLR WEPPPQSTVP IMAVIAALVL LGAVTIIGAV VFFVRKRRNS GRKGQGLSSL SAILEVFSAS WKHTYTPLLL SLTWVCCQFW KLPRVRDFPG LLQLFFSQVE KEAMTIL // ID G3HQR6_CRIGR Unreviewed; 209 AA. AC G3HQR6; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 23-MAY-2018, entry version 31. DE SubName: Full=H-2 class I histocompatibility antigen, L-D alpha chain {ECO:0000313|EMBL:EGW09095.1}; GN ORFNames=I79_013172 {ECO:0000313|EMBL:EGW09095.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW09095.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH000617; EGW09095.1; -; Genomic_DNA. DR ProteinModelPortal; G3HQR6; -. DR PRIDE; G3HQR6; -. DR InParanoid; G3HQR6; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 209 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003444746. FT TRANSMEM 181 205 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 98 172 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 209 AA; 23082 MW; 9F3F3D2604BDAF89 CRC64; MGAVAPRTLL LLLAAALAPT QTRAGESGQA YDGDDYIALN EVLRTLTAAD TAAQITRRKW EQAGVADAWR AYLEEECVES LGRYLEHGKD QLLRTGDVTL RCWAMGFSPA DITLTWQREE EEQTQDMELV ETRPSGDGTF QKWASLVVPS GEEQKYTCHL YHEGLPEPLT LRWEPPPQST VPIMAVIAVL VLLVTIITAV VAVSLSQPF // ID G3HVT4_CRIGR Unreviewed; 390 AA. AC G3HVT4; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 45. DE SubName: Full=CHLA class I histocompatibility antigen, A-126 alpha chain {ECO:0000313|EMBL:EGW13253.1}; DE SubName: Full=MHC class I antigen Hm1-C5 {ECO:0000313|EMBL:ERE88521.1}; GN ORFNames=H671_1g2985 {ECO:0000313|EMBL:ERE88521.1}, GN I79_015076 {ECO:0000313|EMBL:EGW13253.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW13253.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). RN [2] {ECO:0000313|EMBL:EGW13253.1} RP NUCLEOTIDE SEQUENCE. RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line."; RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Proteomes:UP000030759} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17A/GY {ECO:0000313|Proteomes:UP000030759}; RX PubMed=23929341; DOI=10.1038/nbt.2645; RA Brinkrolf K., Rupp O., Laux H., Kollin F., Ernst W., Linke B., RA Kofler R., Romand S., Hesse F., Budach W.E., Galosy S., Muller D., RA Noll T., Wienberg J., Jostock T., Leonard M., Grillari J., Tauch A., RA Goesmann A., Helk B., Mott J.E., Puhler A., Borth N.; RT "Chinese hamster genome sequenced from sorted chromosomes."; RL Nat. Biotechnol. 31:694-695(2013). RN [4] {ECO:0000313|EMBL:ERE88521.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=17A/GY {ECO:0000313|EMBL:ERE88521.1}; RA Brinkrolf K., Rupp O., Laux H., Kollin F., Ernst W., Linke B., RA Kofler R., Romand S., Hesse F., Budach W.E., Galosy S., Muller D., RA Noll T., Wienberg J., Jostock T., Leonard M., Grillari J., Tauch A., RA Goesmann A., Helk B., Mott J.E., Puehler A., Borth N.; RT "Chinese hamster genome sequenced from sorted chromosomes."; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH000802; EGW13253.1; -; Genomic_DNA. DR EMBL; KE665736; ERE88521.1; -; Genomic_DNA. DR Proteomes; UP000001075; Unassembled WGS sequence. DR Proteomes; UP000030759; Unassembled WGS sequence. DR GO; GO:0009986; C:cell surface; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 390 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5010496919. FT TRANSMEM 298 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 390 AA; 44999 MW; CCDC0B3E66DE30BA CRC64; METSLLCTLH LLLGASLALT QTFEGSHSLR YFDIAVSRPG LEETLYMTAG YVENTEFVHF NSATVNPRFE PRVPWMEQVG QEYWDDQTHI AKSAKQQIRA CFQKLQGYYN QSQNSPHTIQ RMTGCYIGHD GHLFHAYRQF GYDGEDYLTL NEDLSTWIAA DTAAKITKQQ WVATNEAEFW RVYLQGPCVV WLLKYPKMGN PPKAYVTHHP RPEGDITLRC WALSFYPADT TLTWQRDGED QTQDMELVET RPSGDGTFQK WAVVVVPSRE EQRYTCHVHH EGLPEPLTLR WSRSPQSFIP IIVVAVVLLL LGALVATIEM WRKSSGRERG SLSFPSNWGI QAPDSFLPPC WEGVWPINSQ RHNSECHYPK YLDLKRLKSP KYNIFVFNFK // ID G3HVV6_CRIGR Unreviewed; 759 AA. AC G3HVV6; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 34. DE SubName: Full=HLA class I histocompatibility antigen, A-24 alpha chain {ECO:0000313|EMBL:EGW13275.1}; GN ORFNames=I79_015098 {ECO:0000313|EMBL:EGW13275.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW13275.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH000802; EGW13275.1; -; Genomic_DNA. DR PRIDE; G3HVV6; -. DR InParanoid; G3HVV6; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.30.500.10; -; 3. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 3. DR Pfam; PF00129; MHC_I; 2. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 3. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF54452; SSF54452; 3. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS00290; IG_MHC; 2. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 219 241 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 395 418 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 706 729 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 297 385 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 608 694 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 759 AA; 87023 MW; E9E9567E265D0FB9 CRC64; MEHCAPWVDQ QQPEYWEKLT VDMLSGLESC KVLLKEVLLI YNQSETGYHT VEFRMSCDVL PGSNYIHGQY EIIINGLDYI ALNEDLSTWT AVGKAAEILT QQWEKIGHTK TLRPFLEGEC VQRLHSHLDY GKEILLRRDT PKLHVTHKIP WKWQKDGSNQ NLDMEVIETR PAGDGTFQKW AAVVVPPGEE QSYTCHVNHE GLPEPLTLRW EPPQPSVPIM PIVIGLILGA VLMGAVVTFL IRKWRNKVGK AAEILTQEWD KTVFVKSVTS FLKNKCVTFL LQHLDYGKEF LLRTDIPKFH VTHKVRADGT ITLRCWALDF YHSDITLTWQ RDGSNQNLDI EVMDTRPARD GTFQKWAAVV VPLGEEQRYT CHVYYEGLPE PLTLRWEPPQ LSVPIMPIVT GLVLGVVLMG AVVTFLIWKR RNKGSHSLTY LQTLLTWPDP LASHFIGSAY LDDIHIERLN TITQTPKLEH CAPWLDQQQP EYWEQSTLGM LNLRDFYKRL LKKVLHIYNQ SETGYHTVQF RMSCDVLPGV NYIRGQYEMI FNGHDYIALN EDLTTWTAVG KAAEVLSQEF EKKSYAKNLR PLLEGECVQS LLAQLDYGKE ILLRKDIPKL HVTHKVRADG NITLRCWAQD FYHAEITLTW QKDGSNQNLD MEVIETRPAG DGTFQKWAAV VVPPGEEQRY TCHVNHEGLP ESITLRWEPP QPSVPIMPIV TGLVLGAVLM GAVVTFLIWK WRSKGKKRSG SEFICPWEYQ AQLRVCPAS // ID G3HVV8_CRIGR Unreviewed; 373 AA. AC G3HVV8; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 23-MAY-2018, entry version 34. DE SubName: Full=Class I histocompatibility antigen, GOGO-A0101 alpha chain {ECO:0000313|EMBL:EGW13277.1}; GN ORFNames=I79_015100 {ECO:0000313|EMBL:EGW13277.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW13277.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH000802; EGW13277.1; -; Genomic_DNA. DR ProteinModelPortal; G3HVV8; -. DR PRIDE; G3HVV8; -. DR InParanoid; G3HVV8; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 2. DR Pfam; PF00129; MHC_I; 2. DR SMART; SM00407; IGc1; 2. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS00290; IG_MHC; 2. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 158 181 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 60 148 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 281 369 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 373 AA; 43012 MW; 6BA3238D047FA128 CRC64; MGFDSRAESQ RMQHRAPWLD QQKPKYWEEE TQSILREEKF FKEVMKKVLH VYNQSMSEKP QIHVTHKIRA DGKITLRCLA LNFYPAEITL TWQREGNNQT QDMEVMDTRP AGDGTFQKWA AVVVPPGEEQ RYTCHVHHEG LPEPLTLRWE PRQPSVPIMP IVAGLVFGAV LMGAVVTFLI WKRRTKGYHT VQILIACDVL PGGKFSHGQC KLIFDGHDYI ALNEDLNTWT AFGKAAEILM EEWENTAFAK SVTPYLMNGC VHYLLKELHY EKAFLMRTDI PKLHVTHKVR ADGNITLRCW ALDIYHAEIT LTWQRDGSNQ NLDMEVIETR PAGDGTFQKW AAVVVPPGEE QRYTCHVNHE GLPEPLTLRW GKQ // ID G3HVV9_CRIGR Unreviewed; 262 AA. AC G3HVV9; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 23-MAY-2018, entry version 29. DE SubName: Full=HLA class I histocompatibility antigen, A-24 alpha chain {ECO:0000313|EMBL:EGW13278.1}; DE Flags: Fragment; GN ORFNames=I79_015101 {ECO:0000313|EMBL:EGW13278.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW13278.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH000802; EGW13278.1; -; Genomic_DNA. DR ProteinModelPortal; G3HVV9; -. DR PRIDE; G3HVV9; -. DR InParanoid; G3HVV9; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 2. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 235 259 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 139 227 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:EGW13278.1}. SQ SEQUENCE 262 AA; 30170 MW; EFE6E61698047BA9 CRC64; SHWLQSFDTV TYGPDTWEPR FIHVCYVDAT QVMGFDSNAA TAKMEPRAPW MKQEPPEYWK EETQEALYKS QGDRKFLEVL MNYYKHSKGE GKAAQLIKQT WETHHKAEHW RTYLQGKCVE MLRRCLDLGK ETLLRSDPPQ TYVTHQVRPG GNVTLRCWAL NFYPAEITLS WQRDGNNQTQ DIELGDTRPA GDGTFQKWAA VVVPSGEELR YTCHVNHEGL PEPRILRWEP PLPTISLMVI LIGLLLGALV MGTVAIFLIQ KK // ID G3HVW0_CRIGR Unreviewed; 332 AA. AC G3HVW0; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 23-MAY-2018, entry version 33. DE SubName: Full=CHLA class I histocompatibility antigen, A-126 alpha chain {ECO:0000313|EMBL:EGW13279.1}; GN ORFNames=I79_015102 {ECO:0000313|EMBL:EGW13279.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW13279.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH000802; EGW13279.1; -; Genomic_DNA. DR ProteinModelPortal; G3HVW0; -. DR PRIDE; G3HVW0; -. DR InParanoid; G3HVW0; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 332 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003444703. FT TRANSMEM 304 324 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 332 AA; 38052 MW; 8760BC18003C19BC CRC64; MTPRTLLLLL AAALAPTQTR AGSHSLRYFG TAMTQPGHGE PRFVAFGFVD DTRFVWFDSD AVTPREEPRA RWMEEKRPEY WERQTRIAKA NAQIFRDNLR TLLRYYNQSE AGYHTIQSMR GCYMGSDGRF LGGYYRTAYD GADHISLNED LRSWTAANKV ALITQRKYEA TNEAEHHRAY LKVTCMEWLR SHLEKGKEIL QRADPPKTHL THHPRPEGDI TLKCWALGFY PADITLTWQR DRKEQTQDME LVDTRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP LTLRWAPPPQ HIDLIVGVAA GLVLLGAAVT AVVWRKLPRR NV // ID G3HZH5_CRIGR Unreviewed; 252 AA. AC G3HZH5; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 23-MAY-2018, entry version 31. DE SubName: Full=H-2 class I histocompatibility antigen, L-D alpha chain {ECO:0000313|EMBL:EGV95300.1}; GN ORFNames=I79_016479 {ECO:0000313|EMBL:EGV95300.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV95300.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH000969; EGV95300.1; -; Genomic_DNA. DR ProteinModelPortal; G3HZH5; -. DR PRIDE; G3HZH5; -. DR InParanoid; G3HZH5; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 173 195 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 88 162 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 252 AA; 27940 MW; FD4E9B9E8267BE39 CRC64; MYGCHVGSDG RLLRGYRQVA YDGDDYIALN EVLRTLTAAD TAAQITRRKW EQAGVADAWR AYLEEECVES LGRYLEHGKD QLLRTGDVTL RCWAMGFYPA EITLTWQREE EEQSQDMELV ETRPSGDGTF QKWAAVVVPS GEEQKYTCHV YHEGLPEPLT LRWEPPPQST VCFLAVIAAL VLIGAVIIGA VVFFVRKRRN SGGKEGTYAP APAPHITASV PFPSVADVAR DFIQGCLCVE HVLTDHTSAP LA // ID G3I5E5_CRIGR Unreviewed; 306 AA. AC G3I5E5; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 35. DE SubName: Full=Zinc-alpha-2-glycoprotein {ECO:0000313|EMBL:EGW05032.1}; GN ORFNames=I79_018690 {ECO:0000313|EMBL:EGW05032.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW05032.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH001296; EGW05032.1; -; Genomic_DNA. DR RefSeq; XP_003510460.1; XM_003510412.1. DR RefSeq; XP_007625243.1; XM_007627053.1. DR ProteinModelPortal; G3I5E5; -. DR GeneID; 100773168; -. DR KEGG; cge:100773168; -. DR CTD; 563; -. DR InParanoid; G3I5E5; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 306 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003444911. FT DOMAIN 202 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 306 AA; 34790 MW; F843D044171CB01A CRC64; MVPVLLSLPL LLGPAVLQET GPYSLVFLYT GLSRPSKGIP RFQATAFLND QAFFHYNSNS GKVEPVGPWS QIEGMEDWEK ESQLQKAREE IFLVTLKDIM DYYKDSAGSH TFQGMFGCEL LNNRSSGAFW RYAYDGQDFI EFNKEIPAWI PLDPAAVNTK QKWEAEKAYT QRAKAYLEEE CPTMLKRYLN YSRSHLDQKD PPTVTITSHT APGRNRIFKC LAYDFYPQGI SLHWNQAGKM LTSKSGGVFP NGNGTYLSWV EVEVPAQDRD PYFCHIEHSG LSQSLSVQWD ETRKAKAESN MATQPQ // ID G3IFL9_CRIGR Unreviewed; 499 AA. AC G3IFL9; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 23-MAY-2018, entry version 34. DE SubName: Full=H-2 class I histocompatibility antigen, K-W28 alpha chain {ECO:0000313|EMBL:EGW01413.1}; GN ORFNames=I79_022542 {ECO:0000313|EMBL:EGW01413.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW01413.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH002416; EGW01413.1; -; Genomic_DNA. DR PRIDE; G3IFL9; -. DR InParanoid; G3IFL9; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 2. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 2. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 499 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003445195. FT TRANSMEM 271 293 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 412 434 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 314 402 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 499 AA; 56114 MW; 64D3F3BFEFAEC4AE CRC64; MVIPVVCVLL LPVAALAPTQ TRPGSHSLRY FRTIMSRPGL GEPRFISVGY VDDTQFVRFD SDAEYPRMEP RAPWVEREEP DYWERNTRIA KNNEQAFRVS LRTLLRYYNQ SEGGSHTYQR MYGCHVGSDG RLLRGYSQEA YDGRDYITLN EDLRTWTAAD TAAQITRRKW EQAGVACRWM EGLPGGHVRG VAPQTPRERE GPAAAHREKE EQTQDMELVE TRPSGDGTFQ KWAAVVVPSG EEQKYTCHVR HEGLPEPLTL RWEPPQSTVP IMAVIAVLVL LGVVTIITAV VVVRKRRRNT GEKRGKYAPA PDPPKAHVTH HPGSKGDVTL RCWAMGFYPA DITLTWQREK EEQTQDMELV ETRPSGDGTF QKWAAVVVPS GEEQKYTCHV RHEGLPEPLT LRWEPPQSTV PIMAVIAVLV LLGVVTIITA VVVVRKRRRN TGLLAPFAPT QLQDSHQASK RPSTVHLVQC SLQGAESLQD IQLQELPVDN KSTGDSEDL // ID G3IFM0_CRIGR Unreviewed; 223 AA. AC G3IFM0; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 34. DE SubName: Full=H-2 class I histocompatibility antigen, L-D alpha chain {ECO:0000313|EMBL:EGW01414.1}; GN ORFNames=I79_022543 {ECO:0000313|EMBL:EGW01414.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW01414.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH002416; EGW01414.1; -; Genomic_DNA. DR RefSeq; XP_016822136.1; XM_016966647.1. DR ProteinModelPortal; G3IFM0; -. DR PRIDE; G3IFM0; -. DR GeneID; 100762478; -. DR InParanoid; G3IFM0; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 179 205 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 83 171 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 223 AA; 25288 MW; FADB9DE388A373E2 CRC64; MGSDGRLLRG YDQFAYDGDD YIAMNDDLRT WTAADMAAQI TLRKWEQAGV ALHQRAYLEG ECLEWLSRHL EHGKDQLLRT DPPKTHVTHH PRPEGKVTLK CWALGFYPAD ITLTWMKDEE ELTQYMELVE TRPSGDGTFQ KWAAVEVPVG EEQKYTCHVE HEGLPEPLTL RWEPPQSTIT IMTIAGAVLG AVILVCIIGG VMMWMKKNSD RTSAQRSDLC LEA // ID G3IHQ2_CRIGR Unreviewed; 334 AA. AC G3IHQ2; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 23-MAY-2018, entry version 36. DE SubName: Full=H-2 class I histocompatibility antigen, L-D alpha chain {ECO:0000313|EMBL:EGV96667.1}; GN ORFNames=I79_023357 {ECO:0000313|EMBL:EGV96667.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV96667.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH002836; EGV96667.1; -; Genomic_DNA. DR ProteinModelPortal; G3IHQ2; -. DR PRIDE; G3IHQ2; -. DR InParanoid; G3IHQ2; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 269 295 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 173 261 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 334 AA; 37433 MW; CFE3E819AAA8E470 CRC64; MVSGPGEPRF IVVGYVDDTQ FVRFDSDAET PRYEPRVPWL QKEWPEYWER NTRKAKDSEQ IFRASLRTLL GYYNQSEGGS HTIQLMYGCH VGPDGRLLRG APQYAYDGDD YIALNDDLRT WTAADTAAQI TRRKLQQAGA TERFRAYLEG ECVQWLRRHL ENGKDQLMRT DPPKAHVTHH PGSKGDVTLR CWALGFYPAI ITLIWQKEEE EQTQDMELVE TRPSGDGTFQ KGAALVVPSG EEQKYTCHVH HEGLPEPLTL RWEPPPRSIV PIMALIAALG LLGAVTIIGA LVAVVRKRRR NTGGKGGNYA PAPANPSVPA DSRGHLRPVT SMPP // ID G3IN45_CRIGR Unreviewed; 326 AA. AC G3IN45; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 36. DE SubName: Full=Hereditary hemochromatosis protein-like {ECO:0000313|EMBL:EGW14940.1}; GN ORFNames=I79_025357 {ECO:0000313|EMBL:EGW14940.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW14940.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH005449; EGW14940.1; -; Genomic_DNA. DR ProteinModelPortal; G3IN45; -. DR PRIDE; G3IN45; -. DR InParanoid; G3IN45; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT DOMAIN 211 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 326 AA; 36636 MW; E41A91B6FE7B12DD CRC64; MLFISTYETL RQRIAWFRSL KAELTVGTHE LISTGPHTLH FDLMTTSLDV PDKILALGYF DDKPFLRYKG DNRTAEALRP GIKGHAGAET QARETEGLWK KQLRAMVAEV ARQIDQDRGN HTIQVTFGCE LHRNGSTRGF WRLGYDGQDS ITFDQKTLTW TMAVPSTQQT RNFREIYTPK AAQVFLKDTC PAQLQECLDS SKNILLDTGA PKVKVTSRRY PVGRITLTCW AFNLYPPVAT LVWLQGGKPV QQQTFGPGTI LPSGDGTYQT WVSIWVLPGQ EPEFTCCLRN CSKNIVDPVF LGEKMGQPFT SGGGRQSEGE PVEYNH // ID G3IN54_CRIGR Unreviewed; 282 AA. AC G3IN54; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 32. DE SubName: Full=Hereditary hemochromatosis protein-like {ECO:0000313|EMBL:EGW15054.1}; GN ORFNames=I79_025366 {ECO:0000313|EMBL:EGW15054.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW15054.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH005470; EGW15054.1; -; Genomic_DNA. DR ProteinModelPortal; G3IN54; -. DR PRIDE; G3IN54; -. DR InParanoid; G3IN54; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}. FT DOMAIN 169 261 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 282 AA; 31214 MW; 109FF10AEAB7C1D6 CRC64; MTTSLDVPDK ILALGYFDDK PFLRYKGDNR TAEALTPGIK GHVGAETLAR ETEGLWKEQL RVMLAEVTRQ RNQDRGLHTI QVTFGCELHR NGSTRGFWRL GYDGQDSITF DQKTLAWKMS VSSTKKTKNF WEIYAPKAAQ VKTFLEGTCP AQLQKHLASS KNFLLDTGPP VVKVTSRRYS EDSISLTCSA FNLCPPGATL VWLQGGKPVQ QQTFGPGTIL PGGDETYQTW VSIWVLPGQE PEFTCCLRNC NKAIDAPVFI GEQMGQPFTS GGGMQSEGEP VE // ID G3INM4_CRIGR Unreviewed; 227 AA. AC G3INM4; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 23-MAY-2018, entry version 30. DE SubName: Full=H-2 class I histocompatibility antigen, L-D alpha chain {ECO:0000313|EMBL:EGW12076.1}; GN ORFNames=I79_025552 {ECO:0000313|EMBL:EGW12076.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW12076.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH006581; EGW12076.1; -; Genomic_DNA. DR PRIDE; G3INM4; -. DR InParanoid; G3INM4; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 185 209 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 88 176 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 227 AA; 25659 MW; 8E39713DE4B91EFB CRC64; MYGCHVGLDG RLLRGYEQYA YDGDDYIALN EDLRTWTAAD TAAQITRRKW EQAGFADRQR AYLEEECVGW LRRHLEHGKD QLLRTDPPKA HVTHHPGPKG DVTLRCWVMG FYPADITLIW QREEEEQTQD MELVETRPSG DGTFQKWAAV VVPSGEEQKY TCHVYHEGLP EPLTLRWEPP PQSTVPIMAV IAALGLIGAV IIGALVFFVR KRRNSGGKEG TYAPAPA // ID G3MWG8_BOVIN Unreviewed; 290 AA. AC G3MWG8; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000053867}; GN Name=ULBP21 {ECO:0000313|Ensembl:ENSBTAP00000053867}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000053867, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000053867, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053867, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000053867} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053867}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02027089; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02027090; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02027091; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02027092; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02027093; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005211100.1; XM_005211043.3. DR UniGene; Bt.104971; -. DR ProteinModelPortal; G3MWG8; -. DR STRING; 9913.ENSBTAP00000053867; -. DR PaxDb; G3MWG8; -. DR Ensembl; ENSBTAT00000064751; ENSBTAP00000053867; ENSBTAG00000047902. DR CTD; 513308; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G3MWG8; -. DR OMA; GSLICER; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Reactome; R-BTA-163125; Post-translational modification: synthesis of GPI-anchored proteins. DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000009136; Chromosome 9. DR Bgee; ENSBTAG00000047902; Expressed in 8 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 290 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003447543. FT DOMAIN 44 212 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 290 AA; 32340 MW; 8CA3981E91BDEFAE CRC64; MDRKAGPGAR LGFAAQVLLV ALRFCTARGG PPCAVSQRRT LCNAHSLCYN FTVYPHPSPG EPWCVVQGQV DGNVFLSYHC GGTKIQSTSP LGEEVKTTNT WETQTETLRD IGNFLKGQLP DIIPEKHTAR DPLTLQGRMT CRCEEDGHIS GSWQFGFNGE MCLRFDSENG HWTIDHSRGR QIKEKWENDR AVTDFFKKVS MGDCRAWLQD FMVCWEKMLK TSASPTTGPP TVQPMAPPIK SKPWILPVVL TSFIITFPRL SPFQEQVMLL PGSPNRCSVG LRTQSLLGPL // ID G3MXJ6_BOVIN Unreviewed; 216 AA. AC G3MXJ6; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000054263}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000054263, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000054263, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000054263, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000054263} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000054263}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02027118; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02027119; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02027120; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02027121; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9913.ENSBTAP00000054263; -. DR PaxDb; G3MXJ6; -. DR Ensembl; ENSBTAT00000066107; ENSBTAP00000054263; ENSBTAG00000048114. DR eggNOG; ENOG410JBPA; Eukaryota. DR eggNOG; ENOG411150N; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G3MXJ6; -. DR OMA; WQFAING; -. DR OrthoDB; EOG091G0NI5; -. DR TreeFam; TF339658; -. DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000009136; Chromosome 9. DR Bgee; ENSBTAG00000048114; Expressed in 9 organ(s), highest expression level in liver. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}. FT DOMAIN 1 173 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 216 AA; 24102 MW; C8E11DC0CCA64C83 CRC64; HSLCLDLTVK SQSRPGQPWC QVQGSVDTKP FLQYDSASNK VKPLGFLGKE VNDTKAWTEI SQTLVEAGKE LRMVLPVIKL DENETRGPPT LQVKLCCQRE AEQCSGASLH FSLNGRTALL LDTMSITWTV IDPGATGIKE EWENNQELAE YFRTISTGDC SYWLREFLKH WEKMLVPEPT ESLIMAADIS QSASIRLDSC IILLIITQLV LIASSS // ID G3N1R0_BOVIN Unreviewed; 157 AA. AC G3N1R0; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 38. DE SubName: Full=Major histocompatibility complex class I-related gene protein {ECO:0000313|Ensembl:ENSBTAP00000055813}; GN Name=MR1 {ECO:0000313|Ensembl:ENSBTAP00000055813, GN ECO:0000313|VGNC:VGNC:31595}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000055813, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000055813, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055813, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000055813} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055813}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02043522; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02043523; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSBTAT00000062929; ENSBTAP00000055813; ENSBTAG00000009924. DR VGNC; VGNC:31595; MR1. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000009136; Chromosome 16. DR Bgee; ENSBTAG00000009924; Expressed in 10 organ(s), highest expression level in spleen. DR ExpressionAtlas; G3N1R0; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 157 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003447933. FT TRANSMEM 115 139 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 16 107 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 157 AA; 18263 MW; 3A09A4E382CC459E CRC64; MMLLLPLIIV LMMKLSDARF HTYQRMIGCE LLEDGSITGF LQYAYDGQDF LIFNKDTLSW MAMDNVADII RRVWEANRHE LQYQKNWLEE ECIAWLKRFL EYGKDALQRQ ESETILLVVK AVGFIVLAIA LAGVGILAWR KRPRGKNKVI CLSTPEH // ID G3N2K2_BOVIN Unreviewed; 286 AA. AC G3N2K2; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000056117}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000056117, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000056117, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056117, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000056117} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056117}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02048560; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3N2K2; -. DR STRING; 9913.ENSBTAP00000056117; -. DR PaxDb; G3N2K2; -. DR Ensembl; ENSBTAT00000063976; ENSBTAP00000056117; ENSBTAG00000046595. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G3N2K2; -. DR OMA; DARMWAQ; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Reactome; R-BTA-163125; Post-translational modification: synthesis of GPI-anchored proteins. DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000009136; Chromosome 19. DR Bgee; ENSBTAG00000046595; Expressed in 6 organ(s), highest expression level in heart. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 203 221 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 2 167 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 286 AA; 31936 MW; A60E7401C129ABD1 CRC64; DTHSLFYNFT VDPHPSPGEP WCVVQGQVDG NFFLSYDCGG TKIQSISPLG EEVKTTNAWE TQTETLRDIR DFLKGQLPDI IPEKHTARGP LTLQARMTCQ CEEDGHISGS WQFGFNGEMC LRFDSENGHW TEVHSGGRRM KEKWEKDRAV TDFFKNVSMG DCQTCLQDLI VCWEKTLKTS ASPTTVPHTV QPTAPTSNHI TKIILGVLAG FIIISIVVWI IHKNSRRRCS QEAPDRCSVG LRTQSLLGCF CSPFTLEPRD QTLGIPSLST SYDDTVAAPS RVSCHI // ID G3N4C8_GASAC Unreviewed; 340 AA. AC G3N4C8; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000000148}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000148}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000000148} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000000148} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3N4C8; -. DR STRING; 69293.ENSGACP00000000148; -. DR Ensembl; ENSGACT00000000148; ENSGACP00000000148; ENSGACG00000000116. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3N4C8; -. DR OMA; HIFQRIH; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 340 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003448229. FT TRANSMEM 314 336 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 39068 MW; BEB3BE02FB4038D4 CRC64; MRLVGAEISV LALLMMSLHG AAALTHSLKF FYTGSSGLPN FPEFVAVGLL DEVEIDHYDS DTRRAEPRQD WMSRVIEDDP QYWKSQTEIA MAIQQVYKGN IETLKQRFNQ TGGVHIYQNM YGCEWDNETN KVKGYIQFGY DGEDFISFDL QTEQWIAAKQ KAVITKQKWD QNRADKAHWK NYLTHVCPEW LKKYLNYGRS SLMRTERPSV SLLQKTPSSP VSCHATGFYP DRASLFWRKD EEELHEDVDL GEILPNHDGT FQMRVDLKLS SVPAEDWRRY DCVFQLSGVD EDIVTKLDKT RTNTEKPAGS TSTFIIIIAV AVLVVIMAAV VGFKVYRKRN // ID G3N4D5_GASAC Unreviewed; 228 AA. AC G3N4D5; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000000155}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000155, ECO:0000313|Proteomes:UP000007635}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000000155} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000000155} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSGACT00000000155; ENSGACP00000000155; ENSGACG00000000122. DR GeneTree; ENSGT00910000144007; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 193 218 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 89 176 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 228 AA; 26079 MW; 9B4BEF2E383C4AFA CRC64; MIGCEWDDVT NEVKGYNQYG YDGEDFISFD LQTEQWIAPK QQAVLTKQKW DHDRALKAHD KNYLTHVCPE WLKKFLNYGR SSLMRTERPS VSLLQKTPSS PVSCHATGFY PHRAALFWRK DGEQLHEDVD LGEILPNHDG TFQMRVDLKL SSVPAEDWRR YDCVFQLSGV DEDIVTKLDK TRTNAEKPAG STFIIIIIII IAVVVLVVII AAVVGFMVHR KRNAKCPS // ID G3N4D6_GASAC Unreviewed; 347 AA. AC G3N4D6; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000000156}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000156, ECO:0000313|Proteomes:UP000007635}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000000156} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000000156} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3N4D6; -. DR Ensembl; ENSGACT00000000156; ENSGACP00000000156; ENSGACG00000000122. DR GeneTree; ENSGT00910000144007; -. DR OMA; TETWAGH; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 347 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003448230. FT TRANSMEM 312 337 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 347 AA; 39833 MW; 982FF944E0AEAB7F CRC64; MRLVGAEISV LSLLMMSLHG AAALTHSMKY FYTGSSGVPN FPEFVIVGLL DEVEMFHYDS NTRRAEPRQD WMSRVTEDDP QYWKRQTEKS MDTQQVYKVD IEILKQRFNQ TGGVHIVQLM IGCEWDDVTN EVKGYNQYGY DGEDFISFDL QTEQWIAPKQ QAVLTKQKWD HDRALKAHDK NYLTHVCPEW LKKFLNYGRS SLMRTERPSV SLLQKTPSSP VSCHATGFYP HRAALFWRKD GEQLHEDVDL GEILPNHDGT FQMRVDLKLS SVPAEDWRRY DCVFQLSGVD EDIVTKLDKT RTNAEKPAGS TFIIIIIIII AVVVLVVIIA AVVGFMVHRK RNAKCPS // ID G3N4D9_GASAC Unreviewed; 145 AA. AC G3N4D9; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000000159}; DE Flags: Fragment; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000159, ECO:0000313|Proteomes:UP000007635}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000000159} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000000159} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSGACT00000000159; ENSGACP00000000159; ENSGACG00000000122. DR GeneTree; ENSGT00910000144007; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 1 145 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSGACP00000000159}. SQ SEQUENCE 145 AA; 17267 MW; B86253E349F9DBD1 CRC64; VGLLDEVEMF HYDSNTRRAE PRQDWMSRVT EDDPQYWKSE TETFMGTQQV YKVDIETVKR RFNQTGGVHI VQLMIGCEWD DVTNEVKGYN QYGYDGEDFI SFDLQTEQWI APKQQAVLTK QKWDHDRALK AHDKNYLTHV CPEWL // ID G3N4E0_GASAC Unreviewed; 59 AA. AC G3N4E0; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000000160}; DE Flags: Fragment; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000160, ECO:0000313|Proteomes:UP000007635}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000000160} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000000160} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSGACT00000000160; ENSGACP00000000160; ENSGACG00000000122. DR GeneTree; ENSGT00910000144007; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 1 58 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSGACP00000000160}. SQ SEQUENCE 59 AA; 7236 MW; 2B9BACCA02258EB4 CRC64; VGLLDEVEMF HYDSNTRRAE PRQDWMSRVT EDDPQYWKRQ TEKSMDTQQV YKVDIEILK // ID G3N4E2_GASAC Unreviewed; 334 AA. AC G3N4E2; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000000162}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000162, ECO:0000313|Proteomes:UP000007635}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000000162} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000000162} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3N4E2; -. DR Ensembl; ENSGACT00000000162; ENSGACP00000000162; ENSGACG00000000122. DR GeneTree; ENSGT00910000144007; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 334 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003448118. FT TRANSMEM 300 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 301 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 334 AA; 38233 MW; 518A88FFF6C97CB0 CRC64; MRLVGAEISV LSLLMMSLHG AAALTHSMKY FLTASSGVPN FPEFVIVGLL DEVEMFHYDS NTRRAEPRQD WMSRVTEDDP QYWKSETETF MGTQQVYKVD IETVKRRFNQ TGAGVHIVQF MYGCEWDDET NEVKGYAQDG YDGEDFISFD LQTEQYIAPK QQAVITKQKW DQNRAWIAGK KNYLTHVCPE WVKKHLSYGR SSLMRTERPS VSLLQKTPSS PVSCHATGFY PDRADLFWRK DGEELHEDVD LGEILPNHDG TFQMRVDLKL SSVPAEDWRR YDCVFQLSVN QTEQSSEKPA ASTFIIIIAV AVLVVIIAAV VGFKVHRNRN GERD // ID G3N4E3_GASAC Unreviewed; 325 AA. AC G3N4E3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000000163}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000163, ECO:0000313|Proteomes:UP000007635}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000000163} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000000163} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3N4E3; -. DR Ensembl; ENSGACT00000000163; ENSGACP00000000163; ENSGACG00000000122. DR GeneTree; ENSGT00910000144007; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 194 281 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 325 AA; 37354 MW; 61CAC096BB6453FA CRC64; MSLHGAAALT HSMKYFLTAS SGVPNFPEFV IVGLLDEVEM FHYDSNTRRA EPRQDWMSRV TEDDPQYWKS ETETFMGTQQ VYKVDIETVK RRFNQTGAGV HIVQFMYGCE WDDETNEVKG YAQDGYDGED FISFDLQTEQ YIAPKQQAVI TKQKWDQNRA WIAGKKNYLT HVCPEWVKKH LSYGRSSLMR TERPSVSLLQ KTPSSPVSCH ATGFYPDRAD LFWRKDGEEL HEDVDLGEIL PNHDGTFQMR VDLKLSSVPA EDWRRYDCVF QLSGVDEDIV TKLDKTRTNR GRSETRSGEG GKQTSTLSTL CVLDLFLFVV ILRLG // ID G3N4E4_GASAC Unreviewed; 59 AA. AC G3N4E4; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000000164}; DE Flags: Fragment; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000164, ECO:0000313|Proteomes:UP000007635}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000000164} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000000164} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSGACT00000000164; ENSGACP00000000164; ENSGACG00000000122. DR GeneTree; ENSGT00910000144007; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 1 58 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSGACP00000000164}. SQ SEQUENCE 59 AA; 7117 MW; 3C528D20D93D31A4 CRC64; VGLLDEVEMF HYDSNTRRAE PRQDWMSRVT EDDPQYWKSE TETFMGTQQV YKVDIETVK // ID G3N4E5_GASAC Unreviewed; 336 AA. AC G3N4E5; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000000165}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000165}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000000165} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000000165} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3N4E5; -. DR STRING; 69293.ENSGACP00000000165; -. DR Ensembl; ENSGACT00000000165; ENSGACP00000000165; ENSGACG00000000124. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3N4E5; -. DR OMA; RDLRSWI; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 308 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 204 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 336 AA; 38889 MW; 355D6969126F8C02 CRC64; ENNIIIDYLK CDIRTDDDSF LVPVTHTMKY FLTASSGLPN FPDSVALWLL DEENSNTRRA EPRQDWMSRV TEDDPQYWKS ESETFMGTQQ VYKVDIETVK RRFNQTGAGV HIYQRMVSCE WDDETNEVKG YDQDGYDGED FISFDPETEQ YIAPKQQAVR IKQKWDQDRA RIAHNKNFLT HVFPEWVKKY LSYGRSSLMR TERPSVSLLQ KTPSSPVSCH ATGFYPDRAA LFWRKDGEEL HEDVDLGEIL PNHNGTFQMR VDLKLSSVPA EDWRRYDCVF QLSGVDEDIV TKLDKTRTNT EKPAASTFII IAVAVLVAII AAVVGFKVYR KRNGER // ID G3N4G4_GASAC Unreviewed; 363 AA. AC G3N4G4; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000000184}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000184}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000000184} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000000184} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3N4G4; -. DR STRING; 69293.ENSGACP00000000184; -. DR Ensembl; ENSGACT00000000184; ENSGACP00000000184; ENSGACG00000000141. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3N4G4; -. DR OMA; FQRMIGC; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 363 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003447975. FT TRANSMEM 313 335 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 363 AA; 41266 MW; 74D7240859E232A1 CRC64; MRLVGAEISV LSLLMMSLHG AAALTHSMKF FYTASSGLPN FPEFVIVGLL DEVEMFHYDS NTRRTEPRQD WMSRVTEDDP QYWKSQTEIA MGQQQVFKGH IEIAKQRFNQ TGAGVHIYQN MYGCEWDDET NEVKGYNQDG YDGEDFISFD LQTERWIAPK HQAFITKQKW DHNRALIAGR KNYLTHVCPE WVKKYLNYGR SSLMRTERPS VSLLQKTPSS PVSCHATGFY PDRAALFWRK DGEELHEDVD LGEILPNHDG TFQMRVDLEL SSVPAEDWRR YDCVFQLSGV DEDIVTKLDK TRTNREKPAA STFIIIIAVA VLVAIIAAVV GFKLYRNRNA KPSSSSSAST EGSETSESGL VNI // ID G3N4G5_GASAC Unreviewed; 145 AA. AC G3N4G5; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000000185}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000185}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000000185} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000000185} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSGACT00000000185; ENSGACP00000000185; ENSGACG00000000141. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 1 144 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 145 AA; 17292 MW; 8CE3AF33B1F4E3BF CRC64; VGLLDEVEMF HYDSNTRRTE PRQDWMSRVT EDDPQYWKSQ TEIAMGQQQV FKGHIEIAKQ RFNQTGGVHI YQNMYGCEWD DETNEVKGYN QDGYDGEDFI SFDLQTERWI APKHQAFITK QKWDHNRALI AGRKNYLTHV CPEWV // ID G3N4G6_GASAC Unreviewed; 59 AA. AC G3N4G6; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000000186}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000186}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000000186} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000000186} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSGACT00000000186; ENSGACP00000000186; ENSGACG00000000141. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 1 57 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 59 AA; 7057 MW; 8064BCDB07A76B12 CRC64; VGLLDEVEMF HYDSNTRRTE PRQDWMSRVT EDDPQYWKSQ TEIAMGQQQV FKGHIEIAK // ID G3N4H7_GASAC Unreviewed; 363 AA. AC G3N4H7; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000000197}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000197}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000000197} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000000197} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3N4H7; -. DR STRING; 69293.ENSGACP00000000197; -. DR Ensembl; ENSGACT00000000197; ENSGACP00000000197; ENSGACG00000000151. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3N4H7; -. DR OMA; SALTKTW; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 312 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 363 AA; 41591 MW; B73A00D8AF0A2131 CRC64; LQETQISKFL FKTSQEETSE VPVTHSMKYF YTASSGVPNF PEFVAVGLLD EVEFSHYDSN TRRLEPRQDW MSRVTEDDPQ YWKRYTENFM GAQQVYKGNI ETLKQRFNQT GAGVHINQRM VGCEWDDETN EVKGYDQDGY DGEDFISFDL QTEQWIAPKQ QAVITKRKWD HNRAQIAQNK NYLTHECPEG LKKYLNYGRS SLMRTERPSM SLLQKTPSSP VSCHATGFYP HRAALFWRKD GEELHEDVDL GEILPNHDGT FQMRVDLNLS SVPAEDWRRY DCVFQLSGVD EDIVTKLDKT RTNREKPAGS TFIIIIIAVA VLVVIIAAVV GFKVHRKRNA KPSSSSSATT DGSDVTEELN PKP // ID G3N4H8_GASAC Unreviewed; 362 AA. AC G3N4H8; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000000198}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000198}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000000198} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000000198} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3N4H8; -. DR Ensembl; ENSGACT00000000198; ENSGACP00000000198; ENSGACG00000000151. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003448122. FT TRANSMEM 313 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 41426 MW; 0BE692EA53E921F5 CRC64; MRLVGAEISV LSLLMMSLHG AAALTHSMKY FYTASSGVPN FPEFVAVGLL DEVEFSHYDS NTRRLEPRQD WMSRVTEDDP QYWKRYTENF MGAQQVYKGN IETLKQRFNQ TGAGVHINQR MVGCEWDDET NEVKGYDQDG YDGEDFISFD LQTEQWIAPK QQAVITKRKW DHNRAQIAQN KNYLTHECPE GLKKYLNYGR SSLMRTERPS MSLLQKTPSS PVSCHATGFY PHRAALFWRK DGEELHEDVD LGEILPNHDG TFQMRVDLNL SSVPAEDWRR YDCVFQLSGV DEDIVTKLDK TRTNREKPAG STFIIIIIAV AVLVVIIAAV VGFKVHRKRN AKVQFGSVRQ KDTESFTSAP QI // ID G3N4H9_GASAC Unreviewed; 146 AA. AC G3N4H9; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000000199}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000199}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000000199} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000000199} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSGACT00000000199; ENSGACP00000000199; ENSGACG00000000151. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 1 146 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 146 AA; 17310 MW; DED316F404FF28C5 CRC64; AVGLLDEVEF SHYDSNTRRL EPRQDWMSRV TEDDPQYWKR YTENFMGAQQ VYKGNIETLK QRFNQTGGVH INQRMVGCEW DDETNEVKGY DQDGYDGEDF ISFDLQTEQW IAPKQQAVIT KRKWDHNRAQ IAQNKNYLTH ECPEGL // ID G3N4I0_GASAC Unreviewed; 60 AA. AC G3N4I0; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000000200}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000200}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000000200} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000000200} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSGACT00000000200; ENSGACP00000000200; ENSGACG00000000151. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 1 59 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 60 AA; 7243 MW; 2219C8E124CEEA55 CRC64; AVGLLDEVEF SHYDSNTRRL EPRQDWMSRV TEDDPQYWKR YTENFMGAQQ VYKGNIETLK // ID G3N4I1_GASAC Unreviewed; 59 AA. AC G3N4I1; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000000201}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000201}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000000201} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000000201} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSGACT00000000201; ENSGACP00000000201; ENSGACG00000000151. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 1 58 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 59 AA; 7172 MW; 2219C8A065CEAB14 CRC64; VGLLDEVEFS HYDSNTRRLE PRQDWMSRVT EDDPQYWKRY TENFMGAQQV YKGNIETLK // ID G3N8N8_GASAC Unreviewed; 345 AA. AC G3N8N8; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000001674}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000001674}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000001674} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000001674} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSGACT00000001675; ENSGACP00000001674; ENSGACG00000001288. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 345 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003448365. FT TRANSMEM 299 319 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 183 278 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 345 AA; 38678 MW; 9D6177E7269D0671 CRC64; MRLVGAEISV LSLLMMSLHG AAALTHSLKY FYTASSGVPN FPEFVIVGLL DEVEMFHYDS NTRRAEPRQD WMSRVTEDDP QYWKRYTEIL MGSQQVYKGN IETAKQRFNQ TGGLFMFHTF CFISLSDILQ CEQFMDSLEI VITSSAKTRI ISLSPKSGMR VNELKWTASR EGLRRSFLNV TCPSLLSPER PSVSLLQKTP SSPVSCHATG FYPDRAALFW RKDGEELHED VDLGEILPNH DGTFQMRVDL KLSSVPAEDW RRYDCVFQLS GVDEDIVTKL DKTRTNTEKP AGPPPPSTFI IIFIAVAVLV AIIALFISAK RSAAKSPFSS ASTDGSDVTE ELNPK // ID G3N8P2_GASAC Unreviewed; 349 AA. AC G3N8P2; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000001678}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000001678}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000001678} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000001678} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3N8P2; -. DR STRING; 69293.ENSGACP00000001678; -. DR Ensembl; ENSGACT00000001679; ENSGACP00000001678; ENSGACG00000001288. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3N8P2; -. DR OMA; VPGYYNQ; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 302 322 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 186 281 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 349 AA; 39377 MW; 7E5F0C263E63EF4F CRC64; LQETQISKLL FKTSQDETSE VPVTHSLKYF YTASSGVPNF PEFVIVGLLD EVEMFHYDSN TRRAEPRQDW MSRVTEDDPQ YWKRYTEILM GSQQVYKGNI ETAKQRFNQT GVLFTLKKHF QGFISLSDIL QCEQFMDSLE IVITSSAKTR IISLSPKSGM RVNELKWTAH KAREGLRRSF LNVTCPSLLS PERPSVSLLQ KTPSSPVSCH ATGFYPDRAA LFWRKDGEEL HEDVDLGEIL PNHDGTFQMR VDLKLSSVPA EDWRRYDCVF QLSGVDEDIV TKLDKTRTNT EKPAGPPPPS TFIIIFIAVA VLVAIIALFI SAKRSAAKSP FSSASTDGSD VTEELNPKP // ID G3N8P3_GASAC Unreviewed; 59 AA. AC G3N8P3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000001679}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000001679}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000001679} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000001679} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSGACT00000001680; ENSGACP00000001679; ENSGACG00000001288. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 1 58 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 59 AA; 7113 MW; C4F7AD34DF73BB1C CRC64; VGLLDEVEMF HYDSNTRRAE PRQDWMSRVT EDDPQYWKRY TEILMGSQQV YKGNIETAK // ID G3NAN8_GASAC Unreviewed; 344 AA. AC G3NAN8; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002383}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002383}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002383} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002383} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 69293.ENSGACP00000002383; -. DR Ensembl; ENSGACT00000002390; ENSGACP00000002383; ENSGACG00000001837. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3NAN8; -. DR OMA; RITQRFY; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 344 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003448426. FT TRANSMEM 317 337 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 344 AA; 39506 MW; B07112331A6AADA2 CRC64; MRLVGAEISV LSLLMMSLHG AAALTHSLKN FYTGSSGVPN FPEFVVVGLL DEVEISHYDS NTRREEPRQD WMSRVTEDDP QYWKSETEIL MGQQQGFKVN IETAKQRFNQ TGAGVHIYQN MYGCEWDDET NEVKGYYQFG YDGEDFISFD LQTERWIAPK HQAFITKQKW DHNRALIAGK KNYLTHVCPE WVKKYLNYGR SSLMRTERPS VSLLQKTPSS PVSCHATGFY PDRADLFWRK DGEELHEDVD LGEILPNHDG TFQMRVDLKL SSVPAEDWRR YDCVFQLSGV DEDIVTKLDK TRTNRVNQTE QSSEKPAAST VAVLVVIIAA VVGFKVYRKR NGER // ID G3NAP2_GASAC Unreviewed; 60 AA. AC G3NAP2; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002387}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002387}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002387} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002387} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3NAP2; -. DR Ensembl; ENSGACT00000002394; ENSGACP00000002387; ENSGACG00000001837. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 2 59 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 60 AA; 7114 MW; D91E1B39FC6347FA CRC64; VVGLLDEVEI SHYDSNTRRE EPRQDWMSRV TEDDPQYWKS ETEILMGQQQ GFKVNIETAK // ID G3NAP4_GASAC Unreviewed; 59 AA. AC G3NAP4; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002389}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002389}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002389} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002389} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSGACT00000002396; ENSGACP00000002389; ENSGACG00000001837. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 1 58 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 59 AA; 7015 MW; D91E1B6FAA6311AC CRC64; VGLLDEVEIS HYDSNTRREE PRQDWMSRVT EDDPQYWKSE TEILMGQQQG FKVNIETAK // ID G3NAY1_GASAC Unreviewed; 359 AA. AC G3NAY1; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002477}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002477}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002477} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002477} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3NAY1; -. DR STRING; 69293.ENSGACP00000002477; -. DR Ensembl; ENSGACT00000002485; ENSGACP00000002477; ENSGACG00000001910. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3NAY1; -. DR OMA; MKNATQT; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 359 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003448254. FT TRANSMEM 313 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 41077 MW; 93CC4548075C28CE CRC64; AEISVLSLLM MSLHGAAALP VTHSLKYFLT ASSGLPNFPE FVGVGLLDEV EFVHYDSDTK RAEPRQDWMS RLTEDDPQYW KRNTELAMDT QQVYKRHIEI LNQSFNQTGG VHINQKMVGC EWDDETNEVK GYDQFGYDGE DFLSFDPETE RWITAKQQAV RIKQKWDQDR ARTAHRKFVL TQECPEWLKK YLSYGRSSLM RTERPSVSLL QKTPSSPVSC HATGFYPDIA DLFWRKDGEE LHEDVDLGEI LPNHDGTFQM RVDLKLSSVP AEDWRRYDCV FQLSGVDEDI VTKLDKTRTN RVNQTEQSSE KPAGSTVAVL VVIIAAVVGF KVYRKRNAKC PSSTDGSEES LRDKLNPKP // ID G3NAY7_GASAC Unreviewed; 364 AA. AC G3NAY7; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002483}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002483}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002483} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002483} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3NAY7; -. DR STRING; 69293.ENSGACP00000002483; -. DR Ensembl; ENSGACT00000002491; ENSGACP00000002483; ENSGACG00000001913. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3NAY7; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003448178. FT DOMAIN 209 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 41839 MW; 692B9D57963F8F2C CRC64; MRLVGAEISV LSLLMMSLHG AAALTHSLKY FLTASSGVPN FPEFVIVGLL DEVEFSHYDS DTKRAEPRQD WMSRVTEDDP QFWKRNTELA MDAQQVYKGH IEIAKQRFNQ TGAGVHIYQR MVGCEWDDET NEVKGYDQFG YDGEDFISFD LQTEQYIAAK QQAVRIKQKW DHNRALKAQN KNYLTHVCPE WLKKHLNYGR SSLMRTERPS VSLLQKTPSS PVSCHATGFY PDRAALFWRK DGEELHEDVD LGEILPNHDG TFQMRVDLKL SSVPAEDWRR YDCVFQLSGV DEDIVTKLDK TRTNTGRSET RSGLWWVPSH SVSWLSVCLR LMLLSVWTGR ESIHLGLKHP STLIEISSIH TIFN // ID G3NAZ2_GASAC Unreviewed; 302 AA. AC G3NAZ2; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002488}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002488}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002488} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002488} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3NAZ2; -. DR Ensembl; ENSGACT00000002496; ENSGACP00000002488; ENSGACG00000001913. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; EDRTHNT; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 270 290 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 164 251 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 302 AA; 34946 MW; 69F0072F979DE96C CRC64; IVGLLDEVEF SHYDSDTKRA EPRQDWMSRV TEDDPQFWKR NTELAMDAQQ VYKGHIEIAK QRFNQTGAGV HIYQRMVGCE WDDETNEVKG YDQFGYDGED FISFDLQTEQ YIAAKQQAVR IKQKWDHNRA LKAQNKNYLT HVCPEWLKKH LNYGRSSLMR TERPSVSLLQ KTPSSPVSCH ATGFYPDRAA LFWRKDGEEL HEDVDLGEIL PNHDGTFQMR VDLKLSSVPA EDWRRYDCVF QLSGVDEDIV TKLDKTRTNT GRSETRSGEG GLLVAVLVVI IAAVVGFKVY RKRNGERDDQ RH // ID G3NAZ5_GASAC Unreviewed; 341 AA. AC G3NAZ5; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002491}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002491}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002491} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002491} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3NAZ5; -. DR STRING; 69293.ENSGACP00000002491; -. DR Ensembl; ENSGACT00000002499; ENSGACP00000002491; ENSGACG00000001919. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3NAZ5; -. DR OMA; TESWIAP; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 341 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003448187. FT TRANSMEM 311 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 204 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 341 AA; 38746 MW; 4383D904BDF826AD CRC64; AEISVLSLLM MSLHGAAALT HSLKFFYTAS SGVPNFPEFV AVGLLDEVEV VHYDSDTRRL EPRQNWVSRL RGDDPQYWKR NTKNSMDAQQ VFKGNIETLK QRFNQTGAGV HIVQNMYGCE WDDVTDEVKG YDQYGYNGED FISFDLQTEQ YIAAKQEASI IKQKWNQNRA LIAGKKNFLT HVCPEGLKKF LNYGRSSLMR TERPSVSLLQ KTPSSPVSCH ATGFYPDRAD LFWRKDGEEL HEDVDLGEIL PNHDGTFQMR VDLKLSSVPA EDWRRYDCVF QLSGVDEDIV TKLDKTRTNT GRSETREAST FIIIIAVAVL VVIIAAVVGF KVYRNRNAKC P // ID G3NAZ6_GASAC Unreviewed; 59 AA. AC G3NAZ6; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002492}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002492}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002492} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002492} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSGACT00000002500; ENSGACP00000002492; ENSGACG00000001919. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 1 58 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 59 AA; 7033 MW; C0F31D9CED047F41 CRC64; VGLLDEVEVV HYDSDTRRLE PRQNWVSRLR GDDPQYWKRN TKNSMDAQQV FKGNIETLK // ID G3NB14_GASAC Unreviewed; 244 AA. AC G3NB14; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002510}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002510}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002510} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002510} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3NB14; -. DR STRING; 69293.ENSGACP00000002510; -. DR Ensembl; ENSGACT00000002518; ENSGACP00000002510; ENSGACG00000001932. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3NB14; -. DR OMA; GREDQCQ; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 191 214 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 87 174 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 244 AA; 27757 MW; 5CB773C804423FCC CRC64; GCEWDDETNE FKGYAQYSYN GEDFISFDLQ TEQWIAAKQQ AVRIKQKWDQ DRADIAGRKF VLTQTCREWL KKYLSYGRSS LMRTERPSVS LLQKTPSSPV SCHATGFYPD RAALFWRKDG EELYEDVDLG EILPNHDGTF QMRVDLNLSS VPAEDWRRYD CVFQLSGVDE DIVTKLDKTR TNTEKPADST FIIIIIAVAV LVVIIAAVVG FKVYRKRNVS AQRSSSSSAS TDGSELSEEL NPKP // ID G3NB16_GASAC Unreviewed; 261 AA. AC G3NB16; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002512}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002512}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002512} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002512} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3NB16; -. DR Ensembl; ENSGACT00000002520; ENSGACP00000002512; ENSGACG00000001935. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 261 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003448188. FT DOMAIN 80 257 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 261 AA; 29649 MW; 4882865E68DEB55B CRC64; MRLVGAEISV LSLLMMSLHG AAAPGWIGNP GLVGTAASHP QGGITYTIWP PVRPSESRSR VHPILVAKFV VEIWGFSPLT HSLKYFYTGS SGVPNFPEFV IVGLVDEVEV VHYDSDTWRL EPRQDWVSRV TEDDHWFWNW QTGLAMNAQR EFKGYIEIAK QRFNQTGGVH IVQNMYGCEW DDETNEVKGY DQYGYNGEDF ISFDLQTEQW IAAKQEASII KQKWDQNRAL IAGKKNFLTH VCPEGLKKFL SYGRSSLMRT G // ID G3NB19_GASAC Unreviewed; 324 AA. AC G3NB19; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002515}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002515}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002515} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002515} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3NB19; -. DR STRING; 69293.ENSGACP00000002515; -. DR Ensembl; ENSGACT00000002523; ENSGACP00000002515; ENSGACG00000001935. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3NB19; -. DR OMA; HYLEEEC; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 193 280 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 324 AA; 37220 MW; 2AB65C88B687C72A CRC64; MGVKSSVPVT HSLKYFYTGS SGVPNFPEFV IVGLVDEVEV VHYDSDTWRL EPRQDWVSRV TEDDHWFWNW QTGLAMNAQR EFKGYIEIAK QRFNQTGGVH IVQNMYGCEW DDETNEVKGY DQYGYNGEDF ISFDLQTEQW IAAKQEASII KQKWDQNRAL IAGKKNFLTH VCPEGLKKFL SYGRSSLMRT ERPSVSLLQK TPSSPVSCHA TGFYPDRAAL FWRKDGEELH EDVDLGEILP NHDGTFQMRV DLKLSSVPAE DWRRYDCVFQ LSGVDEDIVT KLDKTRTNRG RSETRSGEGG KQTSTLFTLC VLDLFLFVVI LRLG // ID G3NB23_GASAC Unreviewed; 340 AA. AC G3NB23; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002519}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002519}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002519} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3NB23; -. DR STRING; 69293.ENSGACP00000002519; -. DR Ensembl; ENSGACT00000002527; ENSGACP00000002519; ENSGACG00000001937. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3NB23; -. DR OMA; NTRICKA; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 288 306 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 186 273 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 38752 MW; 5E415F8193C721CA CRC64; VTHSLKYFYT GSSGLPNFPE FVIVGLVDEV EVVHYDSDTW RLEPRQDWVS RVTEDDHWFW NWQTGLAMNA QREFKGYIKT AKQRFNQTGA GVHIVQNMYG CEWDDETNEV KGYDQYGYNG EDFISFDLQT ERYIAAKQQA SIIKQKWNQN RALIAGKKNF LTHECPEGLK KFLSYGRSSL MRTERPSVSL LQKTPSSPVS CHATGFYPHR AALFWRKDGE ELHEDVDLGE ILPNHDGTFQ MRVDLKLSSV PAEDWRRYDC VFQLSGVDED IVTKLDKTRT NREKPADSTA VAVLVVIIAA VVGFKVHRKR NAQRSSAKPS SSSSASTDGS EVTEELNPKP // ID G3NB26_GASAC Unreviewed; 332 AA. AC G3NB26; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002522}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002522}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002522} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002522} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3NB26; -. DR STRING; 69293.ENSGACP00000002522; -. DR Ensembl; ENSGACT00000002530; ENSGACP00000002522; ENSGACG00000001941. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3NB26; -. DR OMA; VTHHPVF; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT DOMAIN 205 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 332 AA; 37991 MW; 85C91380660A3546 CRC64; LQELYIVELL NTTDVIKVPV THSLKFFLTA SSGLPNFPEF VVVGLLDEVE VVHYDSDTRR AEPRQDWMSR VTEDDPQYWK RNTEINMDTQ QDFKANIEIA KQSFNQTGAG VHIVQRMIGC EWYDETNEVN GYDQYGYDGE DFISFDLQTE QWIAAKQEAS IIKQKWNQNR ALIAGKKNFL THECPEGLKK FLSYGRSSLM RTERPSVFLL QKTPSSPVSC HATGFYPDRA ALFWRKDGEE LHEDVDLGEI LPNHDGTFQM RVDLKLSSVP AEDWRRYDCV FQLSGVDEDI VTKLDKTRTN TGRSETRSGE GGKQTSTLST LCVLDLGSFV FL // ID G3NB27_GASAC Unreviewed; 60 AA. AC G3NB27; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002523}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002523}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002523} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002523} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSGACT00000002531; ENSGACP00000002523; ENSGACG00000001941. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 2 58 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 60 AA; 7183 MW; 0ABE1B2CF7C3956A CRC64; VVGLLDEVEV VHYDSDTRRA EPRQDWMSRV TEDDPQYWKR NTEINMDTQQ DFKANIEIAK // ID G3NB28_GASAC Unreviewed; 145 AA. AC G3NB28; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002524}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002524}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002524} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002524} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSGACT00000002532; ENSGACP00000002524; ENSGACG00000001941. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 1 145 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 145 AA; 17012 MW; 8515B53D3D463FDF CRC64; VGLLDEVEVV HYDSDTRRAE PRQDWMSRVT EDDPQYWKRN TEINMDTQQD FKANIEIAKQ SFNQTGGVHI VQRMIGCEWY DETNEVNGYD QYGYDGEDFI SFDLQTEQWI AAKQEASIIK QKWNQNRALI AGKKNFLTHE CPEGL // ID G3NB30_GASAC Unreviewed; 59 AA. AC G3NB30; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002526}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002526}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002526} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002526} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSGACT00000002534; ENSGACP00000002526; ENSGACG00000001941. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 1 57 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 59 AA; 7084 MW; 0ABE1B7AA1C3C33C CRC64; VGLLDEVEVV HYDSDTRRAE PRQDWMSRVT EDDPQYWKRN TEINMDTQQD FKANIEIAK // ID G3NB65_GASAC Unreviewed; 416 AA. AC G3NB65; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002561}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002561}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002561} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002561} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 69293.ENSGACP00000002561; -. DR Ensembl; ENSGACT00000002570; ENSGACP00000002561; ENSGACG00000001973. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3NB65; -. DR OMA; SCEVIHE; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 416 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5005679940. FT TRANSMEM 322 345 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 416 AA; 46580 MW; 842E1232F11634AD CRC64; MRLVGAEISV LSLLMISLHG AAALTHSLKF VLTASSGVPN FPEFVVVGLL DEVEVVHYDG DTRRAEPRQD WMSRVREDDP QFWKSGTELA MDAQQVFKGY IETAKQSFHQ TGGVHIYQRM AGCEWDDETN EDKGYIQDGY DGEDFISFDL QTEQYIAAKQ QAVITKRKWD HNRAKIAHWK NFLTHVCPEG LKKFLSYGRS SLMRTERPSV SLLQKTPSSP VSCHATGFYP HRAALFWRKD GEQLHEDVDL GEILPNHDGT FQMRVDLNLS SVPAEDWRRY DCVFQLSGMD EDIVTKLDKT RTNTGRPETR SSEGEKPAGS TFIIIIIAVA VLVVIIAAVV GFKVYRKRNA KCSSAKCPSS SSSSSSTDGS DVTEELNPKP LKSASCTQRV APRGHELFTA AVPQSCPQYE HKELLM // ID G3NB67_GASAC Unreviewed; 326 AA. AC G3NB67; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002563}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002563}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002563} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002563} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3NB67; -. DR Ensembl; ENSGACT00000002572; ENSGACP00000002563; ENSGACG00000001973. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 232 255 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 137 229 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 326 AA; 36733 MW; 231C42C319B80CFC CRC64; MSRVREDDPQ FWKSGTELAM DAQQVFKGYI ETAKQSFHQT GGVHIYQRMA GCEWDDETNE DKGYIQDGYD GEDFISFDLQ TEQYIAAKQQ AVITKRKWDH NRAKIAHWKN FLTHVCPEGL KKFLSYGRSS LMRTERPSVS LLQKTPSSPV SCHATGFYPH RAALFWRKDG EQLHEDVDLG EILPNHDGTF QMRVDLNLSS VPAEDWRRYD CVFQLSVNQT EQSSEKPAGS TFIIIIIAVA VLVVIIAAVV GFKVYRKRNA KCSSAKCPSS SSSSSSTDGS DVTEELNPKP LKSASCTQRV APRGHELFTA AVPQSCPQYE HKELLM // ID G3NB68_GASAC Unreviewed; 147 AA. AC G3NB68; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002564}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002564}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002564} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002564} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3NB68; -. DR Ensembl; ENSGACT00000002573; ENSGACP00000002564; ENSGACG00000001976. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3NB68; -. DR OMA; EREACPR; -. DR TreeFam; TF352996; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}. FT DOMAIN 2 147 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 147 AA; 17352 MW; 465612B1FFE509CD CRC64; VVGLLDEVEI VHYDGNTRRT EPRQDWMSRL REDDPQFWDI QTDIAMDAQQ DFKGHTETAK QSFNQTGAGV HIFQRMAGCE WDDETNEVKG YDQFGYDGED FISYDLQTEQ WIAAKPQAVL TKQKWDQDRA DIAWRKNFLT HFCPEWL // ID G3NB70_GASAC Unreviewed; 337 AA. AC G3NB70; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002566}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002566}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002566} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002566} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 69293.ENSGACP00000002566; -. DR Ensembl; ENSGACT00000002575; ENSGACP00000002566; ENSGACG00000001978. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3NB70; -. DR OMA; RREPWYL; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 314 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 203 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 337 AA; 39062 MW; 2BDE299FB02A0233 CRC64; NNILIFLDSI HLIPIVPVTH SMKYFLTASS GVPNFPEFVV VGLLDEVEVV HYDGNTTRAE PRQDWMSRLK EDDPQYWKSR TELAMYTQQD FKGNIETAKQ RFNQTGAGVH IYQRMAGCEW DNETDEVQRY IQDGYDGEDF ISFDLQTKRW IAAKQQAVII QQKWNQDRDK IEYWKNFLTD ECAEGLKTFL NYSRTSLLRT ERPSVSLLQK TPSSPVSCHA TGFYPDRAAL FWRKDGEELH EDVDLGEILP NHDGTFQMRV DLNLSSVPAE DWRRYDCVFQ LSGVDEDIVT KLDKTRTNTD KFIHPFVNSF QVRALSVAVL VVIIAAVVGF KLYRKRK // ID G3NBY2_GASAC Unreviewed; 270 AA. AC G3NBY2; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000002830}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002830}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000002830} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000002830} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3NBY2; -. DR STRING; 69293.ENSGACP00000002830; -. DR Ensembl; ENSGACT00000002840; ENSGACP00000002830; ENSGACG00000002179. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3NBY2; -. DR OMA; THECPEW; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 241 264 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 127 214 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 270 AA; 31219 MW; A9821A98A6F4AAB0 CRC64; WKWYTEILMG NQQVFKANIE TLKQRFNQTG AGVHIFQRMY GCEWDDETNE VKGYYQFGYD GEDFISFDLQ TEQWIAAKQQ AVITKQKWNQ NRAEILYNKN YLTHECPEWL KKFLNYGRSS LMRTERPSVS LLQKTPSSPV SCHATGFYPH RAALFWRKDG EQLHEDVDLG EILPNHDGTF QMRVDLKLSS VPAEDWRRYD CVFQLSGVDE DIVTKLDKTR TNTGRSETRS GEGEKPAGST FIIIIIAVAV LVVIIAAVVG FKVYRKRNGE // ID G3P5H0_GASAC Unreviewed; 368 AA. AC G3P5H0; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Major histocompatibility complex class I ZEA {ECO:0000313|Ensembl:ENSGACP00000012843}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000012843, ECO:0000313|Proteomes:UP000007635}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000012843} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000012843} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 69293.ENSGACP00000012843; -. DR Ensembl; ENSGACT00000012867; ENSGACP00000012843; ENSGACG00000009731. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3P5H0; -. DR OMA; RMFGCEI; -. DR TreeFam; TF334519; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 368 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003449250. FT TRANSMEM 314 338 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 300 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 41328 MW; F81CFF99D73D779E CRC64; MSPLAVLVLL QVTAAVFGVK HSLTYTYTAF AHKPVGLPGI HEFTAMGHLD TRMIDYFDSD QQLKVPKQPW MGERLDKDYW VKGTQSRQSK QQWFKVNIGI LMNRLRQNKT SGQHVLQWQH GCEGEMQLDG TLKFSTGVDM YSYDGYDFLS FDDSNSAWVA GAPAAQQTKR TWDGVDVLKE YTKGYLEKEC MEWMEKFLKY QGSVLENATK PEVYLFASKA KKEANVILTC MATGFYPKEI QLWIKRNGRV LRREDGVMSS GSRPNGDETF QRKDWVEILK TDQSQYTCEV IHKATQVNIE KEWDHKLPEN GSPIGVAVGV PVLVLVLAVV AGVLIFCYRK ASSTSSTSST SSTSSTSSTS SSNTDSIS // ID G3P5H3_GASAC Unreviewed; 357 AA. AC G3P5H3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 41. DE SubName: Full=Major histocompatibility complex class I ZEA {ECO:0000313|Ensembl:ENSGACP00000012846}; OS Gasterosteus aculeatus (Three-spined stickleback). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; OC Gasterosteus. OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000012846, ECO:0000313|Proteomes:UP000007635}; RN [1] {ECO:0000313|Ensembl:ENSGACP00000012846} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGACP00000012846} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3P5H3; -. DR Ensembl; ENSGACT00000012870; ENSGACP00000012846; ENSGACG00000009731. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007635; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007635}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007635}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 357 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003449185. FT TRANSMEM 314 338 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 300 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 357 AA; 40651 MW; 3964657984675E3D CRC64; MSPLAVLVLL QVTAAVFGVK HSLTYTYTAF AHKPVGLPGI HEFTAMGHLD TRMIDYFDSD QQLKVPKQPW MGERLDKDYW VKGTQSRQSK QQWFKVNIGI LMNRLRQNKT SGQHVLQWQH GCEGEMQLDG TLKFSTGVDM YSYDGYDFLS FDDSNSAWVA GAPAAQQTKR TWDGVDVLKE YTKGYLEKEC MEWMEKFLKY QGSVLENATK PEVYLFASKA KKEANVILTC MATGFYPKEI QLWIKRNGRV LRREDGVMSS GSRPNGDETF QRKDWVEILK TDQSQYTCEV IHKATQVNIE KEWDHKLPEN GSPIGVAVGV PVLVLVLAVV AGVLIFCYRK GCIRQLTSKK KGKYFNA // ID G3QHX6_GORGO Unreviewed; 298 AA. AC G3QHX6; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 49. DE SubName: Full=Alpha-2-glycoprotein 1, zinc-binding {ECO:0000313|Ensembl:ENSGGOP00000001964}; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSGGOP00000001964}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000001964, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000001964, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000001964} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030053210; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_004045916.1; XM_004045868.2. DR Ensembl; ENSGGOT00000002006; ENSGGOP00000001964; ENSGGOG00000001993. DR GeneID; 101151331; -. DR KEGG; ggo:101151331; -. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3QHX6; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001519; Chromosome 7. DR Bgee; ENSGGOG00000001993; Expressed in 7 organ(s), highest expression level in liver. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 298 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003451098. FT DOMAIN 207 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 298 AA; 34270 MW; 7541E2C329E8A715 CRC64; MVRMVPVLLS LLLLLGPAVP QENQDGHYSL TYIYTGLSKH VEDIPAFQAL GSLNDLQFFR YNSKDRKSQP MGLWRQVEGM EDWKQDSQLQ KAREDIFMET LKDIVEYYND SNGSHVLQGR FGCEIENNRS SGAFWKYYYD GKDYIEFNKE IPAWVPFDPA AQITKQKWEA EPVYVQRAKA YLEEECPATL RKYLKYSKNI LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT RAGEVQEPEL RGDVLHNGNG TYQSWVVVAV PLQDTAPYSC HVQHSSLAQP LVVPWEAS // ID G3QMS0_GORGO Unreviewed; 244 AA. AC G3QMS0; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 39. DE SubName: Full=UL16 binding protein 3 {ECO:0000313|Ensembl:ENSGGOP00000003815}; GN Name=ULBP3 {ECO:0000313|Ensembl:ENSGGOP00000003815}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000003815, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000003815, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000003815} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030048430; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_004044871.1; XM_004044823.2. DR STRING; 9593.ENSGGOP00000003815; -. DR Ensembl; ENSGGOT00000003910; ENSGGOP00000003815; ENSGGOG00000003891. DR GeneID; 101134479; -. DR KEGG; ggo:101134479; -. DR CTD; 79465; -. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G3QMS0; -. DR KO; K07986; -. DR OMA; WGKQLEM; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000003891; Expressed in 5 organ(s), highest expression level in testis. DR GO; GO:0046658; C:anchored component of plasma membrane; IEA:Ensembl. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IEA:Ensembl. DR GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 244 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003451328. FT DOMAIN 31 206 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 92 112 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 244 AA; 27652 MW; 9CD18D09B448E195 CRC64; MAAAASPAVL PRLAILPYLL FDWSGTGRAD THSLWYNFTI IHLPRHGQQW CEVQSQVDQK NVLSYDCGSD KVLSMGHLEE QLDATDAWGK QLEMLREVGQ RLRLELADTE LEDFTPSGPL MLQARMSCEC EADGCIRGSW QFSFDGQKFL LFDSNNRKWT VVHAGARRMK EKWEKDSGLT TFFKMVSMGD CKSWLRDFLM HRKKRLEPTA PPTVAPGLAQ PKAIATTLSP WSFLIILCFI LPGI // ID G3QSL3_GORGO Unreviewed; 357 AA. AC G3QSL3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=Class I histocompatibility antigen, Gogo-A*0501 alpha chain-like precursor {ECO:0000313|Ensembl:ENSGGOP00000005655}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000005655, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000005655, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000005655} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044048; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044049; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044050; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044051; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044052; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044054; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044055; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044056; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044057; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSGGOT00000005802; ENSGGOP00000005655; ENSGGOG00000005772. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3QSL3; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000005772; Expressed in 7 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 357 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014150744. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 357 AA; 40229 MW; 155B553D061C40E4 CRC64; MAVVAPRTLL LLLSGTLALT RTWAGSHSMR YFYTTMSRPG RGEPRFISVG YVDDTQFVRF DSDDASPREE PRAPWMEREG PEYWDRNTQI CKAQAQTERE NLRIALRYYN QSEGGSHTMQ VMYGCDVGPD GRFLRGYEQH AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAARRAEQL RAYLEGEFVE WLRRYLENGK ETLQRADPPK THMTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPG GDGTFQKWAA VVVPSGKEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLLGA VITGAVVAAM MWRKKSSGGE GVKGSNSAQG SDVSLTA // ID G3QT09_GORGO Unreviewed; 347 AA. AC G3QT09; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 42. DE SubName: Full=Major histocompatibility complex, class I, G {ECO:0000313|Ensembl:ENSGGOP00000005814}; GN Name=HLA-G {ECO:0000313|Ensembl:ENSGGOP00000005814}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000005814, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000005814, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000005814} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044043; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044044; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSGGOT00000005969; ENSGGOP00000005814; ENSGGOG00000008012. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000005772; Expressed in 7 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 347 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014135546. FT TRANSMEM 309 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 347 AA; 38891 MW; F07DF61EF5DBDDDB CRC64; MDGVMATRTL LLLLLGALAL TETWAGSHSM RYFSAAVSRP GRGEPRFIAM GYVDDTQFVR FDSDSACPRM EPRAPWVEQE GPEYWEGETR NTKAHAQTDR MNLQTLRGYY NQSEASSHTL QWMIGCDLGS DGRLLRGYEQ YAYDGKDYLA LNEDLRSWTA ADTAAQISKR KCEAANVAEQ RRAYLEGTCV EWLHRYLENG KEMLQRADPP KTHVTHHPVF DYEATLRCWA LGFYPAEIIL TWQRDGEDQT QDVELVETRP AGDGTFQKWA AVVVPSGEEQ RYTCHVQHEG LPEPLMLRWK QSSLPTIPIM GIVAGLVVLA AVVTGAAVAA VLWRKKSSGK EGVTSGV // ID G3QU39_GORGO Unreviewed; 348 AA. AC G3QU39; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 52. DE SubName: Full=Hemochromatosis {ECO:0000313|Ensembl:ENSGGOP00000006230}; GN Name=HFE {ECO:0000313|Ensembl:ENSGGOP00000006230}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000006230, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000006230, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000006230} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030043834; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_004043416.1; XM_004043368.2. DR STRING; 9593.ENSGGOP00000006230; -. DR Ensembl; ENSGGOT00000006399; ENSGGOP00000006230; ENSGGOG00000006373. DR GeneID; 101126285; -. DR KEGG; ggo:101126285; -. DR CTD; 3077; -. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3QU39; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000006373; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl. DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:Ensembl. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl. DR GO; GO:0030881; F:beta-2-microglobulin binding; IEA:Ensembl. DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl. DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0071281; P:cellular response to iron ion; IEA:Ensembl. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:Ensembl. DR GO; GO:1904283; P:negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:Ensembl. DR GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; IEA:Ensembl. DR GO; GO:1900121; P:negative regulation of receptor binding; IEA:Ensembl. DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; IEA:Ensembl. DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR GO; GO:1904434; P:positive regulation of ferrous iron binding; IEA:Ensembl. DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl. DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IEA:Ensembl. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; IEA:Ensembl. DR GO; GO:1900390; P:regulation of iron ion import; IEA:Ensembl. DR GO; GO:2000008; P:regulation of protein localization to cell surface; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 348 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003451558. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 348 AA; 40138 MW; 42991EB96F63378B CRC64; MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGASEQ DLGLSLFEAL GYVDDQLFVF YDHESRRVEP RTPWVSSRIS SQVWLQLSQS LKGWDHMFTV DFWTIMENHN HSKESHTLQV ILGCEMQEDN STEGYWKYGY DGQDHLEFCP DTLDWRAAEP RAWPTKLEWE RHKIRARQNR AYLERDCPAQ LQQLLELGRG LLDQQVPPLV KVTHHVTSSV TTLRCRALNY YPQNITMKWL KDKQPMDAKE FEPKDVLPNG DGTYQGWITL AVPPGEEQRY TCQVEHPGLD QPLIVIWEPS PSGTLVIGVI SGIAVFFVIL FIGILFIILR KRQGSRGAMG HYVLAERE // ID G3QUS4_GORGO Unreviewed; 379 AA. AC G3QUS4; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000006482}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000006482, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000006482, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000006482} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044169; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044170; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044171; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3QUS4; -. DR Ensembl; ENSGGOT00000006653; ENSGGOP00000006482; ENSGGOG00000006624. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000006624; Expressed in 7 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 379 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014135538. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 379 AA; 42120 MW; B84F0EB42B4CBF0D CRC64; MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFYTSVSRPG RGEPRFIAMG YVDDTQFVRF DSDAASPREE PRAPWMEQEG PEYWDRNTQI YKTSAQTDRV SLRNLRGYYN QSEAGSHTLQ RMYGCDLGPD GRLFRGYNQY AYDGKDYLAL NEDLRSWTAA DTAAQISQRK FEAGGEAEHQ RAYLEGLCVE SLRRYLENGK ETLQRAEPPK THVTHDPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLVV TVAVVAVVAA VMCRRKSSGR EGVRGGVGFF CPAGGFKPQV EVFAASLLGS SIHTGANPA // ID G3QX14_GORGO Unreviewed; 299 AA. AC G3QX14; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=Class I histocompatibility antigen, Gogo-A*0501 alpha chain-like precursor {ECO:0000313|Ensembl:ENSGGOP00000007343}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000007343, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000007343, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000007343} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044048; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044049; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044050; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044051; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044052; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044054; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044055; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044056; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044057; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSGGOT00000007536; ENSGGOP00000007343; ENSGGOG00000005772. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000005772; Expressed in 7 organ(s), highest expression level in testis. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 299 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014182864. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 299 AA; 34372 MW; 8BBF9106993746CE CRC64; MAVVAPRTLL LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWMEQEE PEYWDRQTQI SKTNAQIELE SLRIALRYYN QSEDGSHTIQ RMYGCDVGSD GRFLRGYQQD AYDGKDYIAS NEDLRSWTAA DMAAEITKRK WEAAHFAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHPVSD HEAILRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWV // ID G3QX20_GORGO Unreviewed; 249 AA. AC G3QX20; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000007350}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000007350, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000007350, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000007350} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044179; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044180; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044181; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3QX20; -. DR Ensembl; ENSGGOT00000007543; ENSGGOP00000007350; ENSGGOG00000010807. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000010807; Expressed in 7 organ(s), highest expression level in heart. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR Pfam; PF07654; C1-set; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 172 194 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 69 158 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 249 AA; 27554 MW; CE434BB836F0DBDB CRC64; MGQRDQGLDR ERKGPQDDPG SYQGPERRNF LKEDAMKTKT HYYAMHADCL QELRQYVESG IVLRRTVPPM VNVTRSEASE GNITVTCRAS GFYPWNITLS WRQDGVSLSH DTQQWGDVLP DGNGTYQTWV ATRICQGEEQ RFTCYMEHSG NHSTHPVPSG KVLVLQSHWQ TFHVSAVAAA AAAAAIFVII IFYVRCCKKK TSAAEGPELV SLQVLDQHPV GTGDHRDAAQ LGFQLLMSAP GSTDSTEGA // ID G3QXJ6_GORGO Unreviewed; 241 AA. AC G3QXJ6; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000007539}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000007539, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000007539, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000007539} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030048427; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9593.ENSGGOP00000007539; -. DR Ensembl; ENSGGOT00000007741; ENSGGOP00000007539; ENSGGOG00000007707. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G3QXJ6; -. DR OMA; CKMWLEE; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000007707; Expressed in 5 organ(s), highest expression level in cerebellum. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}. FT DOMAIN 34 196 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 241 AA; 27989 MW; B7E48D1C33CC0EBE CRC64; MTDSTFLYTN PLLCFSSTDT HCLCYDFIIT PKFRPEPRWC EVQGLVDERP FLHYDCVNHK AKAFASLQKK VNVTKTWEEQ TETLRDFSLL SHTNVGDFLK GQLPDIEMEN LIPIERLILQ ARMSCEHEAH GHSRGSWQFL FNGQTFLLFD SNNRKWTALH PRAKKMTEKW EKNKEVTVFF HNISMGDCKT WLEDFLICWE QMLDPTKPPS LTPGTTQPKA MASTLSPWSL LIILCFILPG I // ID G3QY25_GORGO Unreviewed; 246 AA. AC G3QY25; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000007747}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000007747, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000007747, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000007747} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030048428; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSGGOT00000007955; ENSGGOP00000007747; ENSGGOG00000007925. DR GeneTree; ENSGT00390000003472; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000007925; Expressed in 6 organ(s), highest expression level in heart. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 246 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003451820. FT TRANSMEM 224 243 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 30 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 246 AA; 27573 MW; 979DBCFDCED2500F CRC64; VAAAAIPALL LCLPLLFLLF GWSRAGRDDP HSLCYDITII PKFRPGPRWC AVQGQVDKKT FLHYDCGNKT VTPVSPLGNK LNVTKSWKAQ NPVLRKVVDI LTEQLLDIQQ ENYTHKEPLT LQARMSCEQK AEGHSSGSWQ FSFDGQIFLL FDSEKRMWTM VHPEARKMKE MWENDKDVAM SFHYISMGDC AGWLEDFLMG MDSTLEPSAG APLAMSSGTT QLRATATSLI LCCLLIILPC FIFPGI // ID G3QYA4_GORGO Unreviewed; 350 AA. AC G3QYA4; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 45. DE SubName: Full=Major histocompatibility complex, class I, G {ECO:0000313|Ensembl:ENSGGOP00000007834}; GN Name=HLA-G {ECO:0000313|Ensembl:ENSGGOP00000007834}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000007834, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000007834, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000007834} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044043; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044044; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3QYA4; -. DR STRING; 9593.ENSGGOP00000007834; -. DR Ensembl; ENSGGOT00000008046; ENSGGOP00000007834; ENSGGOG00000008012. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3QYA4; -. DR OMA; VTHHPVF; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000008012; Expressed in 7 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl. DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl. DR GO; GO:0002767; P:immune response-inhibiting cell surface receptor signaling pathway; IEA:Ensembl. DR GO; GO:2001199; P:negative regulation of dendritic cell differentiation; IEA:Ensembl. DR GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl. DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl. DR GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; IEA:Ensembl. DR GO; GO:0002666; P:positive regulation of T cell tolerance induction; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 350 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014131343. FT TRANSMEM 312 336 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 213 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 350 AA; 39279 MW; 378E36014701A29D CRC64; RYAEDGVMAT RTLLLLLLGA LALTETWAGS HSMRYFSAAV SRPGRGEPRF IAMGYVDDTQ FVRFDSDSAC PRMEPRAPWV EQEGPEYWEG ETRNTKAHAQ TDRMNLQTLR GYYNQSEASS HTLQWMIGCD LGSDGRLLRG YEQYAYDGKD YLALNEDLRS WTAADTAAQI SKRKCEAANV AEQRRAYLEG TCVEWLHRYL ENGKEMLQRA DPPKTHVTHH PVFDYEATLR CWALGFYPAE IILTWQRDGE DQTQDVELVE TRPAGDGTFQ KWAAVVVPSG EEQRYTCHVQ HEGLPEPLML RWKQSSLPTI PIMGIVAGLV VLAAVVTGAA VAAVLWRKKS SGKEGVTSGV // ID G3R097_GORGO Unreviewed; 368 AA. AC G3R097; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 45. DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSGGOP00000008578}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSGGOP00000008578}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000008578, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000008578, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000008578} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030114358; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030114359; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030114360; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_018870204.1; XM_019014659.1. DR STRING; 9593.ENSGGOP00000008578; -. DR Ensembl; ENSGGOT00000008813; ENSGGOP00000008578; ENSGGOG00000008774. DR GeneID; 101149042; -. DR KEGG; ggo:101149042; -. DR CTD; 2217; -. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3R097; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001519; Chromosome 19. DR Bgee; ENSGGOG00000008774; Expressed in 7 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019864; F:IgG binding; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 301 324 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 40021 MW; BFDAFAF9342C2047 CRC64; MFLESGSSSL PQDFPARVLP SALSLSAESH LSLLYHLTAV SSPAPGTPAF WVSGWLGPQQ YLSYNSLRGE AEPCGAWVWE NQVSWYWEKE TTDLRIKEKL FLEAFKALGG KGPYTLQGLL GCELGPDNTS VPTAKFALNG EEFMNFDLKQ GTWGGDWPEA LAISQRWQQQ DKAANKELTF LLFSCPHRLR EHLERGRGNL EWKEPPSMRL KARPSSPGFS VLTCSAFSFY PPELQLRFLR NGLAAGTGQG DFGPNSDGSF HASSSLTVKS GDEHHYCCIV QHAGLAQPLR VELESPAKSS VLVVGIVIGV LLLTAAAVGG ALLWRRMRSG LPAPWISLRG DDTGVLLPTP GEAQDADSKD VNVIPATA // ID G3R1P6_GORGO Unreviewed; 263 AA. AC G3R1P6; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 39. DE SubName: Full=Retinoic acid early transcript 1E {ECO:0000313|Ensembl:ENSGGOP00000009127}; GN Name=RAET1E {ECO:0000313|Ensembl:ENSGGOP00000009127}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000009127, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000009127, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000009127} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030048422; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_018884917.1; XM_019029372.1. DR STRING; 9593.ENSGGOP00000009127; -. DR Ensembl; ENSGGOT00000009381; ENSGGOP00000009127; ENSGGOG00000009347. DR GeneID; 101132678; -. DR KEGG; ggo:101132678; -. DR CTD; 135250; -. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G3R1P6; -. DR KO; K07987; -. DR OMA; WQFAING; -. DR OrthoDB; EOG091G0NI5; -. DR TreeFam; TF339658; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000009347; Expressed in 2 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IEA:Ensembl. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 227 248 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 31 197 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 263 AA; 30003 MW; 7103A859AEAAEFF2 CRC64; MRRISLTSSP VRLLLLLLLL LIALEIMVGG HSLCFNFTIK LLSRPGQPWC EAQVFLNKNL FLQYNSDNNM VKPLGLLGKK VNATSTWGEL TQTLGEVGRD LRMLLLDIKP QIKTSGPSTL QVEMFCQREA ERCTGASWQF AINGEKSLLF DAMNMTWTVI NHEASKIKET WKKDRGLEKY FRKLSKGDCD HWLREFLGHW EAMPEPTVSP VNASDIHWSS SSVPDRWTIL GAFILLVLMG IVLICVWWQN GEWQAGLWPL RTS // ID G3R2C1_GORGO Unreviewed; 357 AA. AC G3R2C1; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000009367}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000009367, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000009367, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000009367} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044169; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044170; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044171; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3R2C1; -. DR Ensembl; ENSGGOT00000009631; ENSGGOP00000009367; ENSGGOG00000006624. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000006624; Expressed in 7 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 357 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014136929. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 357 AA; 40103 MW; 407A58A30480431E CRC64; MRVTAPRTLL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV NLRKLRGYYN QSEDGSHTLQ SMYGCDLGPD GRLLRGYSQF AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQL RAYLEGTCVE WLRRYLENGR ETLQRADTPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEER YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVTAV ICRRKSSGRE GVKTSDSAQG SDVSLTA // ID G3R3J7_GORGO Unreviewed; 187 AA. AC G3R3J7; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000009826}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000009826, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000009826, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000009826} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044039; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSGGOT00000010108; ENSGGOP00000009826; ENSGGOG00000037193. DR GeneTree; ENSGT00900000141162; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000005772; Expressed in 7 organ(s), highest expression level in testis. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}. FT DOMAIN 101 185 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 187 AA; 20633 MW; A76A364E78159412 CRC64; MDWGDPALGI PHLRRVSLLP LPTCVGSFFL DTHRAAPVLT PIECGVSREA NQCSRGPGSK VPTHPPGLRF SPVAEDGVMA PRTLLLLLSG ALVLTQTWAG EYFHTTMSRP GRADPRFLSV GDVDDTQCVR LDSDATSPRM EPRAPWMEQE GPEYWEEETG TAKAKAQFYR VNLRTLSGYY NQSEACE // ID G3R5G1_GORGO Unreviewed; 212 AA. AC G3R5G1; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000010536}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000010536, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000010536, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000010536} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044179; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044180; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044181; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3R5G1; -. DR Ensembl; ENSGGOT00000010846; ENSGGOP00000010536; ENSGGOG00000010807. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000010807; Expressed in 7 organ(s), highest expression level in heart. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 212 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014167407. FT DOMAIN 25 123 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 212 AA; 23669 MW; 39690E6129192E4D CRC64; MGLGPVLLFL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLAEVH LDGQPFLRCD RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL AHIKDQKEVL QSSDLGHESQ EFLEGRCNED QDTLLRYACR LPAGTTAICR IRHSPEENSA PHGECHPQRG LRGQHYRDMQ GFWLLSLEYH TELASGWGIF EPRHPAVGGC PA // ID G3RAL4_GORGO Unreviewed; 354 AA. AC G3RAL4; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 42. DE SubName: Full=Major histocompatibility complex, class I, E {ECO:0000313|Ensembl:ENSGGOP00000012487}; GN Name=HLA-E {ECO:0000313|Ensembl:ENSGGOP00000012487}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000012487, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000012487, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000012487} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044111; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSGGOT00000012849; ENSGGOP00000012487; ENSGGOG00000012802. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000012802; Expressed in 7 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 354 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014136928. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 354 AA; 39751 MW; 4146D373213281CA CRC64; MIDRTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD DTQFVRFDNE AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR TLRGYYNQSE AGSHTLQWMH GCDLGPDGRF LRGYEQFAYD GKDYLTLNED LRSWTAVDTA AQISERKSND ACEAEHQRAY LEDTCVEWLR KYLEKGKETL LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ DGEGHTQDTE LVDTRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP LTLRWKPASQ PTIPIVGIIA GLVLLGSVVS GAVVAAVIWR KKSSGGEGRR VGSCFCSTPG SDSA // ID G3RQV0_GORGO Unreviewed; 345 AA. AC G3RQV0; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=Major histocompatibility complex, class I, E {ECO:0000313|Ensembl:ENSGGOP00000018173}; GN Name=HLA-E {ECO:0000313|Ensembl:ENSGGOP00000018173}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000018173, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000018173, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000018173} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044111; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9593.ENSGGOP00000018173; -. DR Ensembl; ENSGGOT00000023546; ENSGGOP00000018173; ENSGGOG00000012802. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3RQV0; -. DR OMA; EDRTHNT; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000012802; Expressed in 7 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 345 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014134106. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 345 AA; 38961 MW; 59F8566DA24A8366 CRC64; MIDRTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD DTQFVRFDNE AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR TLRGYYNQSE AGSHTLQWMH GCDLGPDGRF LRGYEQFAYD GKDYLTLNED LRSWTAVDTA AQISERKSND ACEAEHQRAY LEDTCVEWLR KYLEKGKETL LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ DGEGHTQDTE LVDTRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP LTLRWKPASQ PTIPIVGIIA GLVLLGSVVS GAVVAAVIWR KKSSGGKGRS YSKAE // ID G3RRN0_GORGO Unreviewed; 275 AA. AC G3RRN0; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000018454}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000018454, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000018454, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000018454} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030053210; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSGGOT00000029931; ENSGGOP00000018454; ENSGGOG00000001997. DR GeneTree; ENSGT00740000114936; -. DR OMA; ILKCLAY; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001519; Chromosome 7. DR Bgee; ENSGGOG00000001997; Expressed in 2 organ(s), highest expression level in liver. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 275 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014154908. FT DOMAIN 184 263 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 275 AA; 31438 MW; 7C1C586BA411139C CRC64; MVRMVSVLLS LLLLLGPAVP QETRDGHYSL TYLYTGLSKP GCRALTVFLN GRAFFHYNSE DRKAEPLGPW RHVEGVEDWE KQSQVQNARE DIFMETLNNI MEYYNDSNGS HALKERFGSF WKNAYDGKDY IEFNKEIPAW VPLVPEAEPV YVQRAKAYLE EECPATLRKY LKYSKNILDR QDPPCVVVTS HQAPGEKKKL KCLAYDFYPG KTDVHWTRAG EVQEPELRGD VLHGGNGTYQ TWLLVHVPPQ DTAPYSCHVQ YSSLAQPLLV PGEAR // ID G3RUA1_GORGO Unreviewed; 398 AA. AC G3RUA1; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000019378}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000019378, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000019378, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000019378} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044086; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSGGOT00000031790; ENSGGOP00000019378; ENSGGOG00000038876. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000005772; Expressed in 7 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 398 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014139673. FT TRANSMEM 325 346 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 250 307 IGc1. {ECO:0000259|SMART:SM00407}. SQ SEQUENCE 398 AA; 43835 MW; D5B48F2E816739B7 CRC64; MAPRTLLLLL SGTLALAETW AGECGVRRET ASAVRSDRSV AGPGEPRREE GRAGLSPSSP PGSHSMRYFS TAVSRPGRGE PRFIAVGYVD DTQFVRVDSD AVSLRMKTRA RWVEQEGPEY WDLQTLGAKA QAQTDRLNLR TLLRYYNQSE AAYHILQGMF GCDLGPDGRL LRGYEQYAYD GKDYIALNED LRSWTAADTA AANVAEQRRA YLEGTCTEWL RRHLENGKET LQRADPPKTH VTHHPVSEHE ITLTWQRDGE DQTQDMELVE TRPAGDGTFQ KWAVVVVPSG EEQRYTCHVQ HKGLPKPLIL RWEPSPQPTI PIVDIIAGLV LLGAVVTGAV VTAVMWRKKS SGGEGVRSSQ SAQGSDVSLT ACKGETLGRL MCVGCWGNSG YSCAMGFL // ID G3S2M3_GORGO Unreviewed; 325 AA. AC G3S2M3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 42. DE SubName: Full=Class I histocompatibility antigen, Gogo-A*0501 alpha chain-like precursor {ECO:0000313|Ensembl:ENSGGOP00000022321}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000022321, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000022321, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000022321} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044048; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044049; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044050; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044051; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044052; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044054; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044055; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044056; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044057; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSGGOT00000034483; ENSGGOP00000022321; ENSGGOG00000005772. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000005772; Expressed in 7 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 325 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014168739. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 325 AA; 36932 MW; A46399DE9F2C6160 CRC64; MAVVAPRTLL LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWMEQEE PEYWDRQTQI SKTNAQIELE SLRIALRYYN QSEDGSHTIQ RMYGCDVGSD GRFLRGYQQD AYDGKDYIAS NEDLRSWTAA DMAAEITKRK WEAAHFAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHPVSD HEAILRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWDR KGGSYSQAAS SDSAQGSDVS LTACK // ID G3S325_GORGO Unreviewed; 365 AA. AC G3S325; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 47. DE SubName: Full=Class I histocompatibility antigen, Gogo-A*0501 alpha chain-like precursor {ECO:0000313|Ensembl:ENSGGOP00000022475}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000022475, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000022475, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000022475} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044048; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044049; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044050; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044051; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044052; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044054; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044055; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044056; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044057; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSGGOT00000029072; ENSGGOP00000022475; ENSGGOG00000005772. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000005772; Expressed in 7 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. SQ SEQUENCE 365 AA; 41261 MW; D8285FFD64DA2B90 CRC64; MAVVAPRTLL LLLSGTLALT RTWAGSHSMR YFYTTMSRPG RGEPRFISVG YVDDTQFVRF DSDDASPREE PRAPWMEREG PEYWDRNTQI CKAQAQTERE NLRIALRYYN QSEGGSHTIQ RMYGCEVGPD GRFLRGYLQD AYDGKDYITL NEDLRSWTAA DMAAQITQRK WEAAREAERL RAYMEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHPVSD HEAILRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDVSL TACKV // ID G3S4E3_GORGO Unreviewed; 332 AA. AC G3S4E3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000022945}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000022945, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000022945, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000022945} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044169; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044170; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044171; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSGGOT00000024203; ENSGGOP00000022945; ENSGGOG00000006624. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000006624; Expressed in 7 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 332 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014191128. SQ SEQUENCE 332 AA; 37375 MW; 9FEFC93A32535498 CRC64; MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFYTSVSRPG RGEPRFIAMG YVDDTQFVRF DSDAASPREE PRAPWMEQEG PEYWDRNTQI YKTSAQTDRV SLRNLRGYYN QSEAGSHTLQ RMYGCDLGPD GRLFRGYNQY AYDGKDYLAL NEDLRSWTAA DTAAQISQRK FEAGGEAEHQ RAYLEGLCVE SLRRYLENGK ETLQRAEPPK THVTHDPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWGK EGDEGSCLFS GKAGALQQAS DSAQGSDVSL TA // ID G3S7T7_GORGO Unreviewed; 370 AA. AC G3S7T7; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000024147}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000024147, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000024147, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000024147} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044169; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044170; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044171; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSGGOT00000034380; ENSGGOP00000024147; ENSGGOG00000006624. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000006624; Expressed in 7 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 370 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014120220. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 370 AA; 41241 MW; A72ADE5221FAA57C CRC64; MRVTAPRTLL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV NLRKLRGYYN QSEDGSHTLQ SMYGCDLGPD GRLLRGYSQF AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQL RAYLEGTCVE WLRRYLENGR ETLQRADTPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEER YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVTAV ICRRKSSGGK GGSCSQAACS NSAQGSDESL ITCKGEILGS // ID G3S957_GORGO Unreviewed; 362 AA. AC G3S957; G3S6A9; G3S6S4; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000024622}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000024622, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000024622, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000024622} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044169; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044170; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044171; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_004043674.1; XM_004043626.2. DR Ensembl; ENSGGOT00000027743; ENSGGOP00000023616; ENSGGOG00000006624. DR Ensembl; ENSGGOT00000029032; ENSGGOP00000024622; ENSGGOG00000006624. DR Ensembl; ENSGGOT00000033635; ENSGGOP00000023781; ENSGGOG00000006624. DR GeneID; 101142998; -. DR KEGG; ggo:101142998; -. DR GeneTree; ENSGT00760000118960; -. DR KO; K06751; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000005772; Expressed in 7 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015091541. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40426 MW; A12B9EBCBB6DFE4A CRC64; MRVTAPRTLL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV NLRKLRGYYN QSEDGSHTLQ SMYGCDLGPD GRLLRGYSQF AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQL RAYLEGTCVE WLRRYLENGR ETLQRADTPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEER YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVTAV ICRRKSSGGK GGSYSQAASS DSAQGSDVSL TA // ID G3SAH3_GORGO Unreviewed; 363 AA. AC G3SAH3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000025096}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000025096, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000025096, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000025096} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044169; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044170; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044171; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSGGOT00000031218; ENSGGOP00000025096; ENSGGOG00000006624. DR GeneTree; ENSGT00760000118960; -. DR OMA; MKNATQT; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000006624; Expressed in 7 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 363 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014132747. FT TRANSMEM 306 327 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 363 AA; 40703 MW; 970419B92A533168 CRC64; MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFYTSVSRPG RGEPRFIAMG YVDDTQFVRF DSDAASPREE PRAPWMEQEG PEYWDRNTQI YKTSAQTDRV SLRNLRGYYN QSEAGSHTLQ RMYGCDLGPD GRLFRGYNQY AYDGKDYLAL NEDLRSWTAA DTAAQISQRK FEAGGEAEHQ RAYLEGLCVE SLRRYLENGK ETLQRAEPPK THVTHDPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLVV TVAVVALTHP IIPPVPRLLR ALTRSCFCST PASDSAQGEI LGV // ID G3SD53_GORGO Unreviewed; 350 AA. AC G3SD53; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 41. DE SubName: Full=Major histocompatibility complex, class I, E {ECO:0000313|Ensembl:ENSGGOP00000026032}; GN Name=HLA-E {ECO:0000313|Ensembl:ENSGGOP00000026032}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000026032, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000026032, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000026032} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044111; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_004043621.1; XM_004043573.2. DR Ensembl; ENSGGOT00000031939; ENSGGOP00000026032; ENSGGOG00000012802. DR GeneID; 101153360; -. DR KEGG; ggo:101153360; -. DR GeneTree; ENSGT00760000118960; -. DR KO; K06751; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000012802; Expressed in 7 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 350 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014125870. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 350 AA; 39507 MW; 3DD8B88F2CE9F856 CRC64; MIDRTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD DTQFVRFDNE AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR TLRGYYNQSE AGSHTLQWMH GCDLGPDGRF LRGYEQFAYD GKDYLTLNED LRSWTAVDTA AQISERKSND ACEAEHQRAY LEDTCVEWLR KYLEKGKETL LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ DGEGHTQDTE LVDTRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP LTLRWKPASQ PTIPIVGIIA GLVLLGSVVS GAVVAAVIWR KKSSGGKGRS YSKAEWSDSA // ID G3SDI2_GORGO Unreviewed; 341 AA. AC G3SDI2; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 47. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSGGOP00000026162}; GN Name=MR1 {ECO:0000313|Ensembl:ENSGGOP00000026162}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000026162, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000026162, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000026162} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030007640; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_004028051.1; XM_004028002.2. DR STRING; 9593.ENSGGOP00000026162; -. DR Ensembl; ENSGGOT00000030376; ENSGGOP00000026162; ENSGGOG00000022903. DR GeneID; 101150279; -. DR KEGG; ggo:101150279; -. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3SDI2; -. DR OMA; GYVDSHP; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001519; Chromosome 1. DR Bgee; ENSGGOG00000022903; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 341 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003453547. FT TRANSMEM 300 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 203 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 341 AA; 39355 MW; 38900281C1878619 CRC64; MGELMAFLLP LIIVLMVKHS DSRTHSLRYF RLGISDPIHG VPEFISVGYV DSHPITTYDS VTRQKEPRAP WMAENLAPDH WERYTQLLRG WQQMFKVELK RLQRHYNHSG SHTYQRMIGC ELLEDGSTTG FLQYAYDGQD FLIFSKDTLS WLAVDNVAHT IKQAWEANQH ELLYQKNWLE EECIAWLKRF LEYGKDTLQR TEPPVVRVNR KETFPGVTAL FCKAHGFYPP EIYMTWMKNG EEIVQEIDYG DILPSGDGTY QTWASVELDP QSSNLYSCHV EHCGVHMVLQ VPQESETIPL VMKAVSGSIV LVIVLAGVGV LVWRRRPREQ NGAIYLPTPD R // ID G3SGJ7_GORGO Unreviewed; 365 AA. AC G3SGJ7; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 44. DE SubName: Full=Class I histocompatibility antigen, Gogo-A*0501 alpha chain-like precursor {ECO:0000313|Ensembl:ENSGGOP00000027233}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000027233, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000027233, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000027233} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044048; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044049; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044050; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044051; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044052; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044054; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044055; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044056; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044057; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSGGOT00000022877; ENSGGOP00000027233; ENSGGOG00000005772. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000005772; Expressed in 7 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003453934. FT TRANSMEM 306 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 41001 MW; 6445FF61BC9D2517 CRC64; MAVVAPRTLL LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWMEQEE PEYWDRQTQI SKTNAQIELE SLRIALRYYN QSEDGSHTIQ RMYGCDVGSD GRFLRGYQQD AYDGKDYIAS NEDLRSWTAA DMAAEITKRK WEAAHFAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHPVSD HEAILRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDVSL TACKV // ID G3SHS8_GORGO Unreviewed; 387 AA. AC G3SHS8; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 48. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000027668}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000027668, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000027668, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000027668} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CABD030044179; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044180; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030044181; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_018884422.1; XM_019028877.1. DR STRING; 9593.ENSGGOP00000027668; -. DR Ensembl; ENSGGOT00000026170; ENSGGOP00000027668; ENSGGOG00000010807. DR GeneID; 101144699; -. DR KEGG; ggo:101144699; -. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3SHS8; -. DR KO; K07985; -. DR OMA; LVLQSHW; -. DR OrthoDB; EOG091G0ANY; -. DR TreeFam; TF342166; -. DR Proteomes; UP000001519; Chromosome 6. DR Bgee; ENSGGOG00000010807; Expressed in 7 organ(s), highest expression level in heart. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 387 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014150719. FT TRANSMEM 310 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 387 AA; 42992 MW; 7CB5D45FF95CCAD6 CRC64; MGLGPVLLFL AGIFPFAPPG AAAEPHSLRY NLMVLSQDGS VQSGFLAEGH LDGQPFLRCD RQKRRAKPQG QWAEDVLGAE TWDTETEDLT ENGQDLRRTL THIKDQKGGL HSLQEIRVCE IHEDSSTRGS RHFYYDGELF LSQNLETEEW TTPQSSRAQT LAMKVRNFLK EDAMKTKTHY YAMHADCLQE LRQYVESGIV LRRTVPPMVN VTRSEASEGN ITVTCRASGF YPWNITLSWR QDGVSLSHDT QQWGDVLPDG NGTYQTWVAT RICQGEEQRF TCYMEHSGNH STHPVPSGKV LVLQSHWQTF HVSAVAAAAA AAAIFVIIIF YVRCCKKKTS AAEGPELVSL QVLDQHPVGT GDHRDAAQLG FQLLMSAPGS TDSTEGA // ID G3SNY1_LOXAF Unreviewed; 376 AA. AC G3SNY1; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000001366}; DE Flags: Fragment; GN Name=LOC100662084 {ECO:0000313|Ensembl:ENSLAFP00000001366}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000001366, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000001366} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001366}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000001366} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001366}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9785.ENSLAFP00000001366; -. DR Ensembl; ENSLAFT00000001638; ENSLAFP00000001366; ENSLAFG00000027580. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3SNY1; -. DR OMA; VTHHPVF; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 376 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003454309. FT TRANSMEM 310 336 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSLAFP00000001366}. SQ SEQUENCE 376 AA; 41480 MW; 01A8F02A57253B43 CRC64; TGVMAPRTLL LLLLGALALT QTRAGSHSLR YFHTAVSRPG RGEPRFISVG YVDDTEFVWF DSDAANPRME PRAPWIEQEG PEYWDQETQN AKVTAQNYRV NLRTLRGYYN QSDAGSGSHT LQRMYGCEVG PDGRLLRGYL QFAYDGADYL ALNEDLSSWT AADRAAQISK GKFEKGGEAE YRRAYLEGSC VQWLSKYLEK GKETLQRVDP PKTLMTYHRI SDHETTLKCW ALGFYPAEIT LTWQRDGEDQ TQDMELVETR PAGDGTFQKW AALVVPSGEE QKYTCRVQHE GLSEPVTLRW ELSSQASTPI IGVVAGLLLL GAVVLGVVVA GAVVMWRKKN SGRDGDEAGG KGGSYTQGSS SNSDQGSDVS LIASKG // ID G3SRG9_LOXAF Unreviewed; 340 AA. AC G3SRG9; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000002478}; GN Name=LOC100664043 {ECO:0000313|Ensembl:ENSLAFP00000002478}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000002478, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000002478} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000002478}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000002478} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000002478}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3SRG9; -. DR STRING; 9785.ENSLAFP00000002478; -. DR Ensembl; ENSLAFT00000002973; ENSLAFP00000002478; ENSLAFG00000022788. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3SRG9; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 340 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003454346. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 38072 MW; 6EFD7CBEFBCB8DBF CRC64; IVSQILLFLL SGPLALTQAR AGSHSLRYFD TVVSRPGRGE PRYIAVGYVD DTEFVRFDSD AVNPRAEPRA PWMEQEGPEY WDRETRSAKG TAQAFRVSLR NVRGYYNQSD AAGSHTFQRI YGCEVGPDGL FLRGYAQYAY DGSDYITLSQ DMRSWTAADT TAQITQRKWE ADKYADQVKA YLEGACVEGL RRYLENGKES LQRADPPKAH VTNHPISDHE VMLRCWALGF YPAEITLTWQ RDGEDQTQDT ELVETRPAGD GTFQKWVAIV VLSGEKQRYT CRVQHEGLPK PLTLRWEPLP QSTIPVMGIV AGLVLFGALA FGAVVAAVVI LRKRSSGRDG // ID G3SUA4_LOXAF Unreviewed; 308 AA. AC G3SUA4; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSLAFP00000003713}; GN Name=MR1 {ECO:0000313|Ensembl:ENSLAFP00000003713}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000003713}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000003713} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000003713}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000003713} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000003713}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLAFT00000004447; ENSLAFP00000003713; ENSLAFG00000004447. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 279 302 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 182 275 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 308 AA; 35558 MW; 4BD06F92A6FA5DC4 CRC64; GTHSLRYFRL GVSDPGHGIP EFISVGYVDS HPITTYDSVT RKKEPRAPWM AENLAPDHWE RYTQLLRGWQ QTFRVELKHL QSHYNHSGGF HTYQRMIGCE LLEDGSTTGF LQYAYDGQDF ITFQKDTLSW TAVDSVAQIT KQAWEANRHE LQYQKNWLET ECIAWLKRFL EYGKDTLQRT EPPLIKVNRK ETSPGITTLF CRAHGFYPPE ISMTWMKNGE EIIQEIDYGD ILPSGDGTYQ TWISIEIDSQ DSNIYSCHVE HCDLHMVLQV PRELEIIPLV MKAISGSIVL VIVLAGVGIL AWKRRHRG // ID G3SWF6_LOXAF Unreviewed; 338 AA. AC G3SWF6; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000004650}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000004650, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000004650} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004650}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000004650} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004650}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLAFT00000005541; ENSLAFP00000004650; ENSLAFG00000029650. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3SWF6; -. DR OMA; NTRICKA; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 338 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003454536. FT TRANSMEM 306 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 74 94 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 338 AA; 37825 MW; 95AD2681D2BE48DB CRC64; MASQVLLFLL SGSLALTQTQ AGSHSLSHFF TAVSRPGGGE PRVIAVGYVD DTQLGRFDSD AANPRAEPRT WWMEQEEQEH LEELTRRAKG VAQNLRVHLW TLRGYYNQSA SGSHTIQWLS ACDLRSDGRF LRGYRQMAYD GTDYIALNED LRSWTAADAA AQITQREWEE AGRAERVRAF LEGDCVEWLY RYLEKGKETL LRADPPKAYV THHPISDHEV TLRCWALGFY PVEITLTWQR DGEDQTQDTE LVETRPAGDG TFQKWAALVV PSGEEQRYVC RVQHEGLSEP LTLRWVEVPP QPTTSILGIV AGLVLLGAVV TGVVIWIKKS SGRGGAGV // ID G3T4P5_LOXAF Unreviewed; 363 AA. AC G3T4P5; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000008346}; DE Flags: Fragment; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000008346, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000008346} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008346}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000008346} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3T4P5; -. DR STRING; 9785.ENSLAFP00000008346; -. DR Ensembl; ENSLAFT00000009966; ENSLAFP00000008346; ENSLAFG00000027473. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3T4P5; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 363 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003454616. FT TRANSMEM 304 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSLAFP00000008346}. SQ SEQUENCE 363 AA; 40291 MW; 02B9528D09355458 CRC64; TRVMAPRALL LLLSGALALT QTRAGSHSLR YFDTTVSRPG GGEPRFIEVG YVDDTQFVRF DSDAANPRME PRAPWIEQEG PEYWDRNTQI AKDNAQTSRV SLRTAGYYNQ SDAGDHTIQV MYGCEVGPDG RLLRGYGQHA YDGADYIALN EDLSSWTAAD TAAQITQRKW EAEKYADQFR AYVEGRCQES LRRYLENGKE SLQRADPPKA HITHHPISDR EATLRCWALG FYPAEITLTW QRDGEDQTQD MELVETRPAG DGTFQKWAAM VVPSGEEQRY TCHVQHEGLP KPLTLTWESR SQSFAIIMGI IAGLVFLVVV VAVVAAAVIW RKKSSDGKGG NYAQAASSNS SQGSDVSLMA CKG // ID G3THV5_LOXAF Unreviewed; 361 AA. AC G3THV5; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 50. DE SubName: Full=Hemochromatosis {ECO:0000313|Ensembl:ENSLAFP00000014186}; GN Name=HFE {ECO:0000313|Ensembl:ENSLAFP00000014186}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000014186}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000014186} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014186}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000014186} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014186}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3THV5; -. DR STRING; 9785.ENSLAFP00000014186; -. DR Ensembl; ENSLAFT00000016923; ENSLAFP00000014186; ENSLAFG00000016925. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3THV5; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 361 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003455062. FT TRANSMEM 318 342 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 220 309 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 361 AA; 41252 MW; 0337C20681729311 CRC64; PSREMGPRAQ PAIVLLMLLR TVAPHWRPPR SHSLRYLFMG ASEPDLGLPL FEALGYVDDR LFVSYNHESR HAELRPLWVW TGSSSQLRLQ LSQSLKGWDH MFTVDFWTIM DNYNHSEIMR LGVLSESHTL QVILGCEVQE DNSTWGFWKY GYDGRDHLEF CPETLDWRAA EPRAQATKLE WEVNKIRAKQ NRAYLEKDCP EQLHQLLELG RGVLDQEVPP SLVKVTHHVT SEATTLRCQA LNFLPQNITM KWLKDKQLLE AKEVEPVDIL PNGDGTYQSW MAVAVPPGEE QRYTCQVEHP GLDQPLTATW EPSSPGTLVI GIISGITVCV IIFFIGILFR ILKKRHVSRG TMGDYVLAEG E // ID G3TJB3_LOXAF Unreviewed; 320 AA. AC G3TJB3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000014812}; DE Flags: Fragment; GN Name=LOC100667840 {ECO:0000313|Ensembl:ENSLAFP00000014812}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000014812, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000014812} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014812}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000014812} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014812}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3TJB3; -. DR Ensembl; ENSLAFT00000017663; ENSLAFP00000014812; ENSLAFG00000028462. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3TJB3; -. DR OMA; GINDRTE; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 320 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003455425. FT DOMAIN 203 304 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSLAFP00000014812}. SQ SEQUENCE 320 AA; 36677 MW; E8CC4E356C86C4A5 CRC64; PRTLLVLLSG ALFLTQTKAG SHSLRYFHTA VSRPGRGEPR FIEVGYVDDT QFVRFDSDAA NPRMEPRARW VEREGPEHWD QETRIAKDNA QNYRVNLRTL RGYYNQSDAA HTIQVMFGCE VGSDGRLLRW YNQHAYDGAD YIALNEDLQS WTAADTAAQI TQRKWEEAGV ADHIRAYVEG RCLEWLRRYL ENGKETLRRA VPPRMHMTHH HISDHEATLK CWALGFYPAE ITLTWQRDGE DQTQDIELVE TRPSGDGTFQ KWVVVVVPSG EEHRYTCNVQ HEGLLEPFTL RWETSSQPTS LVMSIVAGLV PVAVVVENVI // ID G3TLR0_LOXAF Unreviewed; 358 AA. AC G3TLR0; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000015894}; DE Flags: Fragment; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000015894, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000015894} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015894}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000015894} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3TLR0; -. DR STRING; 9785.ENSLAFP00000015894; -. DR Ensembl; ENSLAFT00000020739; ENSLAFP00000015894; ENSLAFG00000020929. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3TLR0; -. DR OMA; CVPCCKK; -. DR OrthoDB; EOG091G0HLX; -. DR TreeFam; TF342166; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 358 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003455512. FT TRANSMEM 310 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 224 296 IGc1. {ECO:0000259|SMART:SM00407}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSLAFP00000015894}. SQ SEQUENCE 358 AA; 40376 MW; 9D638921CE935D3E CRC64; WALTTICLFL SLAYLPSSLR PHSVLLRYDI TVVSQDGSVQ TRFVAEEYFD GKLFLQYDSE KGRAEPQGPW AEAQLGAETW DLETMGFTDI RMELRMTLFD IMKLQDQKRG GAGLDSLQET LGCEIQEDDG PGGFWNYCYG KEHFLCCHLE TKRWTVPLSS VQTLALEMRK TWDVDRDKHK YYGHHVEGDI CKRLRSYLDL GRDFMGRTVP PAVNVTLSQA MKGKVTLTHW AAGFYSQKIT LTRLQDGEPL SKGSQESGSV LSSGNGTYVI WVSTSLPQGE EQRYSCHVED SGKNMTHPVS HGETSVQESA WPIVLDVLVA AIVIILIITA LVLRWCRKKN SGGEDTPFPF HQRVTRAE // ID G3TM25_LOXAF Unreviewed; 309 AA. AC G3TM25; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000016095}; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSLAFP00000016095}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000016095}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000016095} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000016095}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000016095} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000016095}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3TM25; -. DR Ensembl; ENSLAFT00000020726; ENSLAFP00000016095; ENSLAFG00000020942. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3TM25; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 309 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003455194. FT DOMAIN 204 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 309 AA; 34920 MW; 2C416671E3C38AB5 CRC64; LVPVLLSLLL LLGPADPRET QTRPYSLIFL YTGLSKPSEG FPRFQATAYL NDQAFFHYNS EGRKAEPLKP WSQLEGIEDW EKESQLQKAR EEIFMVTLKD IMDYYKDGEG SHTFQGMFGC ELWNNKSSGA FWKYAYDGQD FIEFNKEIPA WVPLDPAAQN TKQKWEAEKV YVKRAKAYLE EECPGMLQRY LEHSKALLDQ QDPPSVSVTS HMAPGRSRTL KCLAYDFYPQ GIGLYWTRAG EAQGSESGGD VLPSGNGTYQ SWVVVGVPPQ DRATYACHVE HSSLAQPLTV LWSDIPETKD KGDLGSQPQ // ID G3TMF3_LOXAF Unreviewed; 229 AA. AC G3TMF3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000016287}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000016287, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000016287} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000016287}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000016287} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLAFT00000023061; ENSLAFP00000016287; ENSLAFG00000023055. DR GeneTree; ENSGT00390000003472; -. DR OMA; YEITIIP; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 229 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003455497. FT TRANSMEM 207 227 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 30 176 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 229 AA; 25967 MW; 6545D94C14E412AA CRC64; MALAPDTKFL PGLLILLHLP GWSFAAPADT HCICYNFTVM FKPPPGQRWC EVRGHVDKKI FVLYDCGSRK VITLGPLGMK INATKEWEKQ TETLKDVGDE LKYLLARIKP ENDTTSAPPT LQAEMCCQRE AGRHTGASWR FRFNGQMFLL FDSEKKTWTK VHPEARLMQE EWEKDRDLSP YPNRTSHSGC HMIEGKQICS FSAPPPMAIA TAITLSPWIF LTCLILLGI // ID G3TMJ7_LOXAF Unreviewed; 237 AA. AC G3TMJ7; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000016344}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000016344, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000016344} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000016344}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000016344} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000016344}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3TMJ7; -. DR Ensembl; ENSLAFT00000021744; ENSLAFP00000016344; ENSLAFG00000029735. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3TMJ7; -. DR OMA; SHEACKE; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 194 219 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 95 181 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 237 AA; 26238 MW; DCD24711ACCEE9AE CRC64; GSHTLQRIHG CEVGPDGLFL RGYVQYAYDG ADYITLSQDM RSWTAADTTA QITQRKWEAD KVADQEKAYL EGACVEGLRR YLENGKESLQ RADPPKALVT NHPISDHEVM LRCWALGFYP AEITLTWQRD GEDQTQDMEL VETRPAGDGT FQKWVAMVVP PGEEQRYTCR VQHEGLPKPL TLRWEPPPQS TIPVMGIVAG LVLFGALVVG AVVAAVVILR KRSSGCGGTN SPLPTWT // ID G3TQ28_LOXAF Unreviewed; 351 AA. AC G3TQ28; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000017610}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000017610, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000017610} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017610}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000017610} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017610}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLAFT00000021627; ENSLAFP00000017610; ENSLAFG00000029181. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 351 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003455599. FT TRANSMEM 295 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 196 284 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 351 AA; 37279 MW; 3539AF1930A75AA4 CRC64; TRVMAPRTLL LLLSGALALT QTRAGECGVG GKTASAEGGA RGPLAGDAGP SGKPPPPRAS TRPYTPALIL RSPHLGPLSP LPSRKSDGGA QKGRADLGAG SGSHTIQLMY GCEVGPDGRL LHGYHQYAYD GADYLALNED LSSWTAADSA AQISKGKFEN RGEAEYRRAY LEGACLQWLG KYLENGKETL QRVDPPKTHM THHHISDREA TLRCWALGFY PAEITLTWQR DGEDQTQDME LVETRPAGDG TFQKWAALMV PSGEEQRYTC RVQHEGLSEP VTLRWELSSQ ASTPIIGVVA GLLLLGAVVL GVVVAGAVVM WRKKNSGGKG GSYTQAASSD SAQGSDVSLT A // ID G3TQD6_LOXAF Unreviewed; 360 AA. AC G3TQD6; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000017750}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000017750, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000017750} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017750}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000017750} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017750}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLAFT00000021978; ENSLAFP00000017750; ENSLAFG00000028488. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 360 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003455742. FT TRANSMEM 308 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 360 AA; 39947 MW; 8639DCE6670FE828 CRC64; TLVMASQVLL FLLSGSLALT QTQAGSHSLS HFFTAVSRPG GGEPRIIAVG YVDDTQWGRF DSDAANPRAE PRTWWMEEVE QEHLEELTRR AKGFARDLRV HLWTLRGYYN QSDSSSHTIQ ALSACDVRSD GRFLRGYRQM AYDGTDYIAL NEDLRSWTAA DAAAQITRRE WEEAGEAELA RAFLEGECVE WLHRYLEKGK ETLLRADPPK AYVTHHPISD REVTLRCWAL GFYPVEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA LVVPSGEEQR YVCRVQHEGL SEPLTLRWEV PPHPTTSILG IVAGLVLLGA VVTGVVIWIK KSSGRGGAGV SSPGGNSAQG SEVSFTDSKG // ID G3TQG8_LOXAF Unreviewed; 230 AA. AC G3TQG8; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000017795}; DE Flags: Fragment; GN Name=FCGRT {ECO:0000313|Ensembl:ENSLAFP00000017795}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000017795}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000017795} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017795}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000017795} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017795}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR RefSeq; XP_010585248.1; XM_010586946.1. DR ProteinModelPortal; G3TQG8; -. DR STRING; 9785.ENSLAFP00000017795; -. DR Ensembl; ENSLAFT00000022875; ENSLAFP00000017795; ENSLAFG00000022155. DR GeneID; 100668988; -. DR KEGG; lav:100668988; -. DR CTD; 2217; -. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3TQG8; -. DR OMA; LYSCHER; -. DR OrthoDB; EOG091G0KJB; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 162 186 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 67 154 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSLAFP00000017795}. SQ SEQUENCE 230 AA; 24604 MW; 219273763C2177FB CRC64; NGEEFMTFNP KAGNWSGDWP EAEAIGNLWK KEAEVVNQER AFLLSSCPQR LLGHLELGRG NLEWKEPPSM RLKARPGSPG FSVLTCSAFS FYPPELQLRF LRNGLAAGTG ESDQGPNGDG SFHAWSSLQV KSGDEHHYCC VVQHAGLAKP LTVELESSAR SAVPVVGIVI GLLLLLAAAT GGALLWRRIR AGQPVPWIAL GADDVGALLP TPGLPQEADS QDKNTLADTA // ID G3TR49_LOXAF Unreviewed; 231 AA. AC G3TR49; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000018057}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000018057, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000018057} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018057}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000018057} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3TR49; -. DR Ensembl; ENSLAFT00000036730; ENSLAFP00000018057; ENSLAFG00000023055. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G3TR49; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 231 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003455621. FT TRANSMEM 209 229 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 30 176 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 231 AA; 26409 MW; E26E04E84AD15080 CRC64; MALAPDTKFL PGLLILLHLP GWSFAAPADT HCICYNFTVM FKPPPGQRWC EVRGHVDKKI FVLYDCGSRK VITLGPLGMK INATKEWEKQ TETLKDVGDE LKYLLARIKP ENDTTSAPPT LQAEMCCQRE AGRHTGASWR FRFNGQMFLL FDSEKKTWTK VHPEARLMQE EWEKDRDLRH VCVLIHSSMN PSWENNGHRN FHPIPPPPMA IATAITLSPW IFLTCLILLG I // ID G3TSQ5_LOXAF Unreviewed; 396 AA. AC G3TSQ5; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000018613}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000018613, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000018613} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018613}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000018613} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018613}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9785.ENSLAFP00000018613; -. DR Ensembl; ENSLAFT00000032372; ENSLAFP00000018613; ENSLAFG00000031929. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3TSQ5; -. DR OMA; QPRFIAV; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 396 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003455451. FT TRANSMEM 312 335 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 396 AA; 43887 MW; 55B6E9B754CD0BB6 CRC64; RVMAPRTLLL LLSGALALSQ TRAGSHSLRY FHTAVSRPGR GEPRYIEVGY VDDTQFVRFD SDAANPRMEP RAPWMEQEGP EYWDRNTQNA KGHAQTFRAS LRTLRGYYNQ SDAGSGSHTI RLLYGCEVGA DGRLLRGYHQ YAYDGADYLA LNEDLRSWTA ADTAAQISKG KFEVVRVAEY RRAYLEGACL QWLGKYLENG KETLQRVDPP KTHMTHHCIS DHEATLKCWA LGFHPAEITL TWQRDGEDQT QDMELVETRP AGDGTFQKWA ALVVPSGEEQ RYTCRVQHEG LSEPVTLRWE LSSQASTPKI EVVAGLLLLG TVVLGVVVAG AVVMWRKKNS GGKGGSYTQG SSSDSDQGSD VSLTASKGET LGGLTWMEQG VRQQPCVGLS DTRFVH // ID G3TW96_LOXAF Unreviewed; 320 AA. AC G3TW96; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSLAFP00000019854}; GN Name=MR1 {ECO:0000313|Ensembl:ENSLAFP00000019854}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000019854}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000019854} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019854}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000019854} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019854}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3TW96; -. DR STRING; 9785.ENSLAFP00000019854; -. DR Ensembl; ENSLAFT00000027520; ENSLAFP00000019854; ENSLAFG00000004447. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3TW96; -. DR OMA; GYVDSHP; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 320 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003455863. FT TRANSMEM 297 318 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 320 AA; 36915 MW; D4E1F52CAC203BD6 CRC64; MVLLLPLIVV LMVKHSDART HSLRYFRLGV SDPGHGIPEF ISVGYVDSHP ITTYDSVTRK KEPRAPWMAE NLAPDHWERY TQLLRGWQQT FRVELKHLQS HYNHSGFHTY QRMIGCELLE DGSTTGFLQY AYDGQDFITF QKDTLSWTAV DSVAQITKQA WEANRHELQY QKNWLETECI AWLKRFLEYG KDTLQRTEPP LIKVNRKETS PGITTLFCRA HGFYPPEISM TWMKNGEEII QEIDYGDILP SGDGTYQTWI SIEIDSQDSN IYSCHVEHCD LHMVLQVPRG KDRVMTLSPI SGSIVLVIVL AGVGILAWKR // ID G3TWU7_LOXAF Unreviewed; 362 AA. AC G3TWU7; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000020055}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000020055, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000020055} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020055}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000020055} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020055}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLAFT00000029931; ENSLAFP00000020055; ENSLAFG00000029181. DR eggNOG; ENOG410JB3C; Eukaryota. DR eggNOG; ENOG4111519; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3TWU7; -. DR OMA; HISDREA; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003455619. FT TRANSMEM 306 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 38777 MW; 10C9288A89DFC445 CRC64; RVMAPRTLLL LLSGALALTQ TRAGECGVGG KTASAEGGAR GPLAGDAGPS GKPPPPRAST RPYTPALILR SPHLGPLSPL PSRKSDGGAQ KPSGGERLSL LSLMRKEKRT RSGSHTIQLM YGCEVGPDGR LLHGYHQYAY DGADYLALNE DLSSWTAADS AAQISKGKFE NRGEAEYRRA YLEGACLQWL GKYLENGKET LQRVDPPKTH MTHHHISDRE ATLRCWALGF YPAEITLTWQ RDGEDQTQDM ELVETRPAGD GTFQKWAALM VPSGEEQRYT CRVQHEGLSE PVTLRWELSS QASTPIIGVV AGLLLLGAVV LGVVVAGAVV MWRKKNSGGK GGSYTQAASS DSAQGSDVSL TA // ID G3TYM2_LOXAF Unreviewed; 367 AA. AC G3TYM2; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000020680}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000020680, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000020680} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020680}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000020680} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020680}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLAFT00000032801; ENSLAFP00000020680; ENSLAFG00000028821. DR eggNOG; ENOG410JB3C; Eukaryota. DR eggNOG; ENOG4111519; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3TYM2; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 2. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 367 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003456046. FT DOMAIN 278 364 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 367 AA; 40664 MW; CF9175413818BA1A CRC64; VMAPRTLLLL LSGALALTQA RAGSHSLRYF STAVSRPGRG EPRYISVGYV DDTQFVRFDS DAANPREEPR APWMEQEGPE YWDQETQISK GNTQTSRVNL RTLRGYYNQS DAGESPRPHR PVAPSPRVRT SPRGRGTRPG RAAEIRPGFV FSLEPFGLRP TAASVGGGGG ADGGAGLTAG AGSGSHTIQR MYGCEVGPDG RLLRGYEQHA YDGADYIALN EDLSSWTAAD TAAQITRHKW EAEKVADRIR AYVEGRCQEY LRRYLENGKE SLQRADPPKA HVTHHPISDR EATLRCWALG FYPAEITLTW KRDGEDQTQD MELVETRPAG DGNFQKWAAV VVPSGEEQRY TCHVQHEGLS KPLTLRW // ID G3U6B9_LOXAF Unreviewed; 367 AA. AC G3U6B9; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000023377}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000023377, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000023377} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000023377}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000023377} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000023377}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9785.ENSLAFP00000023377; -. DR Ensembl; ENSLAFT00000032222; ENSLAFP00000023377; ENSLAFG00000028740. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3U6B9; -. DR OMA; VPGYYNQ; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 367 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003456115. FT TRANSMEM 309 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 367 AA; 40748 MW; C11618E21EA55CDE CRC64; TRVMAPRTLL LLLSGALALT QTGAGSHSLR YFDTTVSRPG RGEPRYISVG YVDDTQFVRF DSDAANPRME PRAPWIGQEG PEYWDRNTQI AKDSAQTSRE SLRTALGYYN QSDAGSHTIQ LMYGCEVSPD GRLLHGYHQY AYDGADYLAL NEDLRSWTAA DRAAQMSKRK FENRGVAERW RAYLEGTCLQ WLGKYLENGK ETLQRVDPPK THMTHHRISD REATLRCWAL GFYPAEITLT WQRDGEDQTQ DMELVETRPA GDGTFQKWAA LVVPTGEEQK YTCRVQHEGL SEPVTLRWEL SSQASTPNIG VVAGLLLLGA LVLGVVVAGA VWMWRKKNSG GKGGSYTQGS SSNSDQGSDV SLTASKG // ID G3U7F5_LOXAF Unreviewed; 344 AA. AC G3U7F5; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000023763}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000023763, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000023763} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000023763}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000023763} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000023763}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3U7F5; -. DR STRING; 9785.ENSLAFP00000023763; -. DR Ensembl; ENSLAFT00000027245; ENSLAFP00000023763; ENSLAFG00000028669. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3U7F5; -. DR OMA; TESWIAP; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 344 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003456371. FT DOMAIN 208 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 344 AA; 38760 MW; 2A97CFCF967ED6C2 CRC64; GVMAFQILLQ LLSGALALTQ TRAGSHSLRY FETAVSRPGL EKPRFIAVGY VDNTQFVRFD SDVANPRMEP RAQWVKQEGP EYWDRNTLIA KDNAQAHRVN LRTLRRYYNQ SDAGSHTIQR MSGCEMEPEG YLLRGYTQYA YDGADYIALN EDLSSWTAVA TAAQITQRKW EEAGVAKKKK TYLEDVCVKW LHRYLENGKE SLQRADPPKA HVTNRPISDR AVTLRCWALG FYPAEITLTW QRDGEDQTQD TELVETRPAG DGTFQKWAAM VVPSGEEDRY TCCVQHEGLP EPLILRWDPP PQSTIPIKGI AAGLKLFGVV VVVVAGGRKG RSYTQAANKC VMWA // ID G3U9S3_LOXAF Unreviewed; 377 AA. AC G3U9S3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000024581}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000024581, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000024581} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024581}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000024581} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024581}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLAFT00000031944; ENSLAFP00000024581; ENSLAFG00000031929. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 377 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003456216. FT TRANSMEM 313 336 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 377 AA; 41676 MW; 7EA4600C0DF01A10 CRC64; TRVMAPRTLL LLLSGALALS QTRAGSHSLR YFHTAVSRPG RGEPRYIEVG YVDDTQFVRF DSDAANPRME PRAPWMEQEG PEYWDRNTQN AKGHAQTFRA SLRTLRGYYN QSDAGSGSHT IRLLYGCEVG ADGRLLRGYH QYAYDGADYL ALNEDLRSWT AADTAAQISK GKFEVVRVAE YRRAYLEGAC LQWLGKYLEN GKETLQRVDP PKTHMTHHCI SDHEATLKCW ALGFHPAEIT LTWQRDGEDQ TQDMELVETR PAGDGTFQKW AALVVPSGEE QRYTCRVQHE GLSEPVTLRW ELSSQASTPK IEVVAGLLLL GTVVLGVVVA GAVVMWRKKN SGRDGDEEGG GKGGSYTQGS SSDSDQGSDV SLTASKG // ID G3UAD3_LOXAF Unreviewed; 379 AA. AC G3UAD3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000024791}; DE Flags: Fragment; GN Name=LOC100657492 {ECO:0000313|Ensembl:ENSLAFP00000024791}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000024791, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000024791} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024791}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000024791} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024791}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9785.ENSLAFP00000024791; -. DR Ensembl; ENSLAFT00000034044; ENSLAFP00000024791; ENSLAFG00000032604. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3UAD3; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 379 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003456503. FT TRANSMEM 309 335 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSLAFP00000024791}. SQ SEQUENCE 379 AA; 41871 MW; 42F1BBFBA190F310 CRC64; GVMAPRTLLL LLSGALALTQ TGAGSHSLRY FHTAVSRPGR GEPRFISVGY VDDTEFVWFD SDAANPRMEP RAPWIEQEGP EYWDQETQNA KVTAQNYRVN LRTLRGYYNQ SDAGSGSHTL QRMYGCEVGP DRRLLRGYLQ FAYDGADYLA LNEDLSSWTA ADRAAQISKG KFEKGGEAEY RRAYLEGSCV QWLGKYLEKG KETLQRVDPP KTLITHHRIS DRETTLRCWA LGFYPAEITL TWQWDGEDQT QDMELVETRP AGDGTFQKWA ALVVPSGEEQ RYTCRVQHEG LSEPVTLRWE LSSQASTPII GVVAGLLLLG AVVLGVVVAG AVVMWRKKNS GGKGGSYTQA ASSDSAQGSD VSLVASKGET LGGLTWMEQ // ID G3UB77_LOXAF Unreviewed; 249 AA. AC G3UB77; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000025085}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000025085, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000025085} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000025085}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000025085} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000025085}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9785.ENSLAFP00000025085; -. DR Ensembl; ENSLAFT00000028887; ENSLAFP00000025085; ENSLAFG00000028657. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3UB77; -. DR OMA; VEHESLL; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 191 215 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 94 182 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 249 AA; 27630 MW; 60E2B4E46D90C91C CRC64; SHTIQRMSGC EVGPDGRLLR GYQQHAYDGA DYIALNEDLS SWTAADTAAQ ITQRKWEAEK AADRIRAYVE GRCQEYLRRY LENGKESLQR ADPPKAHITH HPISDREATL RCWALSFYPA EITLTWQRDG EDQTQDMELV ETRPAGDGTF QKWAAMVVPS GEEQRYTCHV QHEGLPKPLT LTWESRSQSP AIIVVIIAGL VFLVVVVALV ARAVIWRKKS SGGKGGNYAQ AASNNSAQGS DVSLMACKG // ID G3UCD5_LOXAF Unreviewed; 368 AA. AC G3UCD5; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000025493}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000025493, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000025493} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000025493}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000025493} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000025493}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLAFT00000036318; ENSLAFP00000025493; ENSLAFG00000028488. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3UCD5; -. DR OMA; SCEVIHE; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 368 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003456129. FT TRANSMEM 309 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 40964 MW; 57591FC8F4D30E39 CRC64; TLVMASQVLL FLLSGSLALT QTQAGSHSLS HFFTAVSRPG GGEPRIIAVG YVDDTQWGRF DSDAANPRAE PRTWWMEEVE QEHLEELTRR AKGFARDLRV HLWTLRGYYN QSDSSSHTIQ ALSACDVRSD GRFLRGYRQM AYDGTDYIAL NEDLRSWTAA DAAAQITRRE WEEAGEAELA RAFLEGECVE WLHRYLEKGK ETLLRADPPK AYVTHHPISD REVTLRCWAL GFYPVEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA LVVPSGEEQR YVCRVQHEGL SEPLTLRWVE VPPHPTTSIL GIVAGLVLLG AVVTGVVIWI KKSSGRGGAG VEKEGTMFRP LGGNSAQGSE VSFTDSKG // ID G3UCH2_LOXAF Unreviewed; 377 AA. AC G3UCH2; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000025530}; DE Flags: Fragment; GN Name=LOC100657492 {ECO:0000313|Ensembl:ENSLAFP00000025530}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000025530, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000025530} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000025530}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000025530} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000025530}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLAFT00000032642; ENSLAFP00000025530; ENSLAFG00000032604. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 377 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003456132. FT TRANSMEM 310 336 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSLAFP00000025530}. SQ SEQUENCE 377 AA; 41551 MW; 5120FD368F4159AC CRC64; TGVMAPRTLL LLLSGALALT QTGAGSHSLR YFHTAVSRPG RGEPRFISVG YVDDTEFVWF DSDAANPRME PRAPWIEQEG PEYWDQETQN AKVTAQNYRV NLRTLRGYYN QSDAGSGSHT LQRMYGCEVG PDRRLLRGYL QFAYDGADYL ALNEDLSSWT AADRAAQISK GKFEKGGEAE YRRAYLEGSC VQWLGKYLEK GKETLQRVDP PKTLITHHRI SDRETTLRCW ALGFYPAEIT LTWQWDGEDQ TQDMELVETR PAGDGTFQKW AALVVPSGEE QRYTCRVQHE GLSEPVTLRW ELSSQASTPI IGVVAGLLLL GAVVLGVVVA GAVVMWRKKN SGRDGDEVPG GKGGSYTQAA SSDSAQGSDV SLVASKG // ID G3UEZ8_LOXAF Unreviewed; 312 AA. AC G3UEZ8; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000026406}; DE Flags: Fragment; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000026406, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000026406} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026406}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000026406} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3UEZ8; -. DR STRING; 9785.ENSLAFP00000026406; -. DR Ensembl; ENSLAFT00000025355; ENSLAFP00000026406; ENSLAFG00000031105. DR eggNOG; ENOG410J90V; Eukaryota. DR eggNOG; ENOG41117CA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3UEZ8; -. DR OMA; TSRMKIF; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 312 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003456404. FT DOMAIN 216 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 175 195 {ECO:0000256|SAM:Coils}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSLAFP00000026406}. SQ SEQUENCE 312 AA; 36246 MW; 87A4D2619810B2AF CRC64; FSETVFLLFY QLTLSPLSMA PTSGPHSLQY FYMAVSEPSP GVPAFTASGF VDDQLFIGYD SVQMQAKPFA HWLREDSDYF DDETKIFTSR MKIFHLNLRN VQQYYNQTQK HSLKEEHLQK PAGPHILQFT YGCELQDDGQ IIGHWQYGYD GNDYLSLDID TLQYTADSFI AQYTKQKWEA NENSIKRDKD YLEKECIWLQ RYLKCGWESL TRTEPPRTHV THHPSPDGEV TLRCWALGFY PAEITLTWQQ DGEDQTQDVE LVETRPSGDG TFQKWAAMVV PSGEEQRYTC RVQHEGLPEP LILRWETPSQ PT // ID G3UFX3_LOXAF Unreviewed; 302 AA. AC G3UFX3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000026731}; DE Flags: Fragment; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000026731, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000026731} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026731}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000026731} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLAFT00000026899; ENSLAFP00000026731; ENSLAFG00000031105. DR eggNOG; ENOG410J90V; Eukaryota. DR eggNOG; ENOG41117CA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}. FT DOMAIN 213 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 172 192 {ECO:0000256|SAM:Coils}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSLAFP00000026731}. SQ SEQUENCE 302 AA; 34976 MW; 5A8D68B9BA3C21CA CRC64; ITGEVFKALT LSPLSMAPTS GPHSLQYFYM AVSEPSPGVP AFTASGFVDD QLFIGYDSVQ MQAKPFAHWL REDSDYFDDE TKIFTSRMKI FHLNLRNVQQ YYNQTQKHSL KEEHLQKPAG PHILQFTYGC ELQDDGQIIG HWQYGYDGND YLSLDIDTLQ YTADSFIAQY TKQKWEANEN SIKRDKDYLE KECIWLQRYL KCGWESLTRT EPPRTHVTHH PSPDGEVTLR CWALGFYPAE ITLTWQQDGE DQTQDVELVE TRPSGDGTFQ KWAAMVVPSG EEQRYTCRVQ HEGLPEPLIL RW // ID G3UGQ5_LOXAF Unreviewed; 316 AA. AC G3UGQ5; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000027013}; DE Flags: Fragment; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000027013, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000027013} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000027013}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000027013} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3UGQ5; -. DR Ensembl; ENSLAFT00000037342; ENSLAFP00000027013; ENSLAFG00000028506. DR eggNOG; ENOG410IGE3; Eukaryota. DR eggNOG; ENOG41114P3; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3UGQ5; -. DR OMA; RMFGCEI; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 287 310 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 190 278 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSLAFP00000027013}. SQ SEQUENCE 316 AA; 36012 MW; 3104BB77BB41659D CRC64; THVSTGTHSL RYHYLALSEP GPGLPQFLAV GYVDDQPFIR YDSRVGRAQS QAPWMVLVDT QYWERETQKQ RGWEKVQQVE MWTVMGYHNL SSGASGKHSA QRMFGCEIQE DGRSNSFWQF GFNGQDHLSL DLDTLSWVSA HPVALRTKRW WETERCYAQY DKAYLQGLCL TSLRRYLELG GQSLTRTEPP KVQVTWHIGQ DGRVTLKCWA LGFYPQDISL SWWLRGEELA LETEHVETRP SGDGTYQKWA AVQVPAGEES GYTCHVQHPG LNHTLTMTYE SPSHPRLIAD LVIFSILVTI SPVAAVVIWI KKKPSG // ID G3UHW1_LOXAF Unreviewed; 365 AA. AC G3UHW1; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000027419}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000027419, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000027419} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000027419}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000027419} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000027419}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLAFT00000030225; ENSLAFP00000027419; ENSLAFG00000028821. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003456775. FT TRANSMEM 307 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 40661 MW; A40FF59E1A6CD91A CRC64; TGVMAPRTLL LLLSGALALT QARAGSHSLR YFHTAVSRPG LGEPRFIAVG YVDTQFGKFD SDANPRAEPA GGRGLSRRGR RHWGRADAES QVHLTDFPEW RLQSLRDYYN HSDAGGSHTF QRMFGCEVDS KGLFLRGRYQ YAYDGADYIS LNEDLRSWTA ADTVAQITQR QWIEAAVSGH KKAFLEGLCV EWLRRYLENG KESLQRADPP KTHVTHHLIS EREATLRCWA LGFYPAEITL TWQRNGEDQT QDMELVETRP TGDGTFQKWA AIVVPFGQEQ RYTCHVQHDG LPKPLTLRWE SHSQYPAIIM GVIAGLILLM VIVAVVAGAV IWRKKQSGRK GGNYAQAGSS KGAQGCDVSL MASKG // ID G3UJT7_LOXAF Unreviewed; 359 AA. AC G3UJT7; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000028096}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000028096, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000028096} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028096}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000028096} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028096}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLAFT00000032329; ENSLAFP00000028096; ENSLAFG00000028821. DR GeneTree; ENSGT00760000118960; -. DR OMA; FQRMIGC; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 359 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003456590. FT TRANSMEM 304 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 40173 MW; 955E21BED66CB067 CRC64; TGVMAPRTLL LLLLGALALT QTRAGSHSLR YFSTAVSRPG RGEPRYISVG YVDDTQFVRF DSDAANPREE PRAPWMEQEG PEYWDQETQI SKGNTQTSRV NLRTLRGYYN QSDAGDHTIQ RMYGCEVGPD GRLLRGYEQH AYDGADYIAL NEDLSSWTAA DTAAQITRHK WEAEKVADRI RAYVEGRCQE YLRRYLENGK ESLQRADPPK AHVTHHPISD REATLRCWAL GFYPAEITLT WKRDGEDQTQ DMELVETRPA GDGNFQKWAA VVVPSGEEQR YTCHVQHEGL SKPLTLRWES RSQFPAIITG VITALVLLVV VMLAGAAIWK KMSSGGKGRK YAQAASSNSA QGSDTSLMA // ID G3UK64_LOXAF Unreviewed; 308 AA. AC G3UK64; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000028223}; DE Flags: Fragment; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000028223, ECO:0000313|Proteomes:UP000007646}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000028223} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028223}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000028223} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3UK64; -. DR Ensembl; ENSLAFT00000037094; ENSLAFP00000028223; ENSLAFG00000028315. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3UK64; -. DR OMA; GYCQEAY; -. DR OrthoDB; EOG091G04DI; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 283 304 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 185 273 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSLAFP00000028223}. SQ SEQUENCE 308 AA; 34757 MW; 0D67B5FD4EC3DFCB CRC64; GSHSLSHFFT AVSRPGGGEP RVIAVAYVDD TQLGRFDSDA ANPRAEPRTW WMEQEEQEHL EELTRRAKGV AQDLRVDLWT LRGYYNQSAS GSHTIQALSA CEVRSDGRFL RGYRQMAYDG TDYIALNEDL RSWTAADAAA QITRREWEEA GVTKLARAFL EEDCLEWLHR YLEKGKETLL RADPPKAYVT HHPISDREVT LRCWALGFYP AEITLTWQRD GEDQTQDTEL VETRPAGDGT FQKWAALVVP SGKEQRYVCH VQHEGLPEPL TLRWMPPHPT TSILGIVAGL VLLGAVVTGV VIWIKKSS // ID G3UWS8_MOUSE Unreviewed; 287 AA. AC G3UWS8; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 51. DE SubName: Full=Histocompatibility 2, M region locus 10.1 {ECO:0000313|Ensembl:ENSMUSP00000133408}; DE Flags: Fragment; GN Name=H2-M10.1 {ECO:0000313|Ensembl:ENSMUSP00000133408, GN ECO:0000313|MGI:MGI:1276522}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000133408, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000133408, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133408, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000133408} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133408}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC129554; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR MaxQB; G3UWS8; -. DR PRIDE; G3UWS8; -. DR Ensembl; ENSMUST00000172576; ENSMUSP00000133408; ENSMUSG00000024448. DR UCSC; uc012asv.1; mouse. DR MGI; MGI:1276522; H2-M10.1. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000024448; Expressed in 25 organ(s), highest expression level in cardiac ventricle. DR ExpressionAtlas; G3UWS8; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 287 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003456901. FT TRANSMEM 262 285 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 165 253 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMUSP00000133408}. SQ SEQUENCE 287 AA; 32594 MW; 7A2AEDF24E84BDED CRC64; XNTGPCTLLL LLMVALDLNH YCAGMQPRAA WIELEPPEYW EKETSRVLEL SQVERQVLRL MVKKNGHKMD GYHTLQEVYG CNVANDGSFL GGHYRLTYYG YDYLTLNEDL SSWTAEGKGA QHAKSRWEDA GEAKRRKTYL QGECVQRLLR YLDLGKETLL CSDAPQTHVT HHVRPEGNVT LRCWALGFYP ADITMTWKRD GNNLTQDMEL PDTRPAGDGT FQKWAAVVVP SGEELRYTCH VHHEGLPEPL TLKWEPPHTI PIIAILIGLV LGTLVVGTVV IFLVWRK // ID G3UWY8_MOUSE Unreviewed; 128 AA. AC G3UWY8; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 55. DE SubName: Full=Histocompatibility 2, T region locus 24 {ECO:0000313|Ensembl:ENSMUSP00000133476}; GN Name=H2-T24 {ECO:0000313|Ensembl:ENSMUSP00000133476, GN ECO:0000313|MGI:MGI:95958}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000133476, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000133476, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133476, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000133476} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133476}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC112970; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3UWY8; -. DR SMR; G3UWY8; -. DR MaxQB; G3UWY8; -. DR PRIDE; G3UWY8; -. DR Ensembl; ENSMUST00000174063; ENSMUSP00000133476; ENSMUSG00000053835. DR MGI; MGI:95958; H2-T24. DR eggNOG; ENOG410J90V; Eukaryota. DR eggNOG; ENOG41117CA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000053835; Expressed in 141 organ(s), highest expression level in blood. DR ExpressionAtlas; G3UWY8; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|MaxQB:G3UWY8}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 128 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003457173. FT DOMAIN 19 106 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 128 AA; 14692 MW; 1D0E4F5740A6D87E CRC64; MWALIFWLLS HPQDGGARSH SLHYCYSAVT EPGPGVPSFF ASGFLDNQPF IHYDSRSMKA EPCADWLREN AQYFTHETEV FTNRMKIFQL SLRNIRQYYN SSGTQSQRAD GFRQQAGQKK ELACSICS // ID G3UXE9_MOUSE Unreviewed; 396 AA. AC G3UXE9; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 59. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMUSP00000133663}; GN Name=Gm8909 {ECO:0000313|Ensembl:ENSMUSP00000133663, GN ECO:0000313|MGI:MGI:3704134}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000133663, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000133663, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133663, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000133663} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133663}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CT030728; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_006524865.1; XM_006524802.3. DR UniGene; Mm.441651; -. DR UniGene; Mm.489198; -. DR ProteinModelPortal; G3UXE9; -. DR SMR; G3UXE9; -. DR MaxQB; G3UXE9; -. DR PRIDE; G3UXE9; -. DR Ensembl; ENSMUST00000173353; ENSMUSP00000133663; ENSMUSG00000073402. DR GeneID; 667977; -. DR MGI; MGI:3704134; Gm8909. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3UXE9; -. DR OMA; QPRFIAV; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000073402; Expressed in 17 organ(s), highest expression level in colon. DR ExpressionAtlas; G3UXE9; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:G3UXE9}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 396 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003457181. FT TRANSMEM 337 360 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 238 326 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 396 AA; 44661 MW; A3A05EDC48A96D13 CRC64; MAPRTLLLLL AAALILTETR AATEGPGRRS GSHREPPPGP HSMRYFTTAV SRPGPHSMRY FETAVSRPGL GEPWFISVGY VDDTQFVRFD GDAENPRMEP RAPWMEQEGP EYWERETQIA KGHEQGFQGS LRNLLHYYNQ SAGGSHTFQR MYGCDLGSDG RLLRGYWQFA YDGSDYIALN QDLKTWTAAD LAAQITRRRW EQGGVAETLR AYLEDPCLEW LRRYLELGKE TLLRTDPPKV HVTHHPRSED DVTLRCWALG FYPADITLTW QLNGEELTQD MELVETRPAG DGTFQKWASV VVPLGKEQNY TCHVYHEGLP EPLTLRWEPR PSRDSNMVII AVLVVLGVVI IIGAMVPFVL KSRRKIGGKE ENYALAGGSN SVQGSALFLE AFSHPS // ID G3UXW2_MOUSE Unreviewed; 289 AA. AC G3UXW2; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 50. DE SubName: Full=H-2 class I histocompatibility antigen, K-K alpha chain {ECO:0000313|Ensembl:ENSMUSP00000133847}; DE Flags: Fragment; GN Name=H2-K1 {ECO:0000313|Ensembl:ENSMUSP00000133847, GN ECO:0000313|MGI:MGI:95904}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000133847, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000133847, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133847, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000133847} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133847}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR974462; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3UXW2; -. DR SMR; G3UXW2; -. DR MaxQB; G3UXW2; -. DR PeptideAtlas; G3UXW2; -. DR PRIDE; G3UXW2; -. DR Ensembl; ENSMUST00000173075; ENSMUSP00000133847; ENSMUSG00000061232. DR MGI; MGI:95904; H2-K1. DR GeneTree; ENSGT00760000118960; -. DR ChiTaRS; H2-K1; mouse. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000061232; Expressed in 279 organ(s), highest expression level in epididymal fat pad. DR ExpressionAtlas; G3UXW2; baseline and differential. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0042605; F:peptide antigen binding; IEA:Ensembl. DR GO; GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IEA:Ensembl. DR GO; GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; IEA:Ensembl. DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl. DR GO; GO:0048839; P:inner ear development; IEA:Ensembl. DR GO; GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|EPD:G3UXW2, KW ECO:0000213|MaxQB:G3UXW2, ECO:0000213|PeptideAtlas:G3UXW2}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 289 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003457228. FT DOMAIN 226 264 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 289 289 {ECO:0000313|Ensembl:ENSMUSP00000133847}. SQ SEQUENCE 289 AA; 32743 MW; 6BC88197FCBDFC02 CRC64; MVPCTLLLLL AAALAPTQTR AARAAARGLV RWSGSHRAPP PGPHSLRYFV TAVSRPGLGE PRYMEVGYVD DTEFVRFDSD AENPRYEPRA RWMEQEGPEY WERETQKAKG NEQSFRVDLR TLLGYYNQSK GGSHTIQVIS GCEVGSDGRL LRGYQQYAYD GCDYIALNED LKTWTAADMA ALITKHKWEQ AGEAERLRAY LEGTCVEWLR RYLKNGNATL LRTDSPKAHV THHSRPEDKV TLRCWALGFY PADITLTWQL NGEELIQDME LVETRPAGDG TFQKWASVV // ID G3UZL7_MOUSE Unreviewed; 220 AA. AC G3UZL7; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 52. DE SubName: Full=H-2 class I histocompatibility antigen, TLA(B) alpha chain {ECO:0000313|Ensembl:ENSMUSP00000134547}; GN Name=H2-T3 {ECO:0000313|Ensembl:ENSMUSP00000134547, GN ECO:0000313|MGI:MGI:95959}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000134547, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000134547, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134547, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000134547} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134547}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CT030728; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3UZL7; -. DR SMR; G3UZL7; -. DR MaxQB; G3UZL7; -. DR PeptideAtlas; G3UZL7; -. DR PRIDE; G3UZL7; -. DR Ensembl; ENSMUST00000172663; ENSMUSP00000134547; ENSMUSG00000054128. DR MGI; MGI:95959; H2-T3. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000054128; Expressed in 15 organ(s), highest expression level in colon. DR ExpressionAtlas; G3UZL7; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|MaxQB:G3UZL7, KW ECO:0000213|PeptideAtlas:G3UZL7}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 220 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003457234. FT DOMAIN 25 202 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 220 AA; 25042 MW; BFB0F70EE860618A CRC64; MGTMVPGTLL ILLAASQGQT QTCPGSHSLR YFYTALSRPA ISEPWYIAVG YLDDTQFVRF NSSGETATYK LSAPWVEQEG PEYWARETEI VTSNAQFFRE NLQTMLDYYN LSQNGSHTIQ VMYGCEVEFF GSLFRAYEQH GYDGRDYIAL NEDLKTWTAA DTAAEITRSK WEQAGYTELR RTYLEGPCKD SLLRYLENRK KTQECTGGLT DTSGVTRKDI // ID G3UZR8_MOUSE Unreviewed; 119 AA. AC G3UZR8; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 51. DE SubName: Full=H-2 class I histocompatibility antigen, TLA(B) alpha chain {ECO:0000313|Ensembl:ENSMUSP00000134607}; GN Name=H2-T3 {ECO:0000313|Ensembl:ENSMUSP00000134607, GN ECO:0000313|MGI:MGI:95959}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000134607, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000134607, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134607, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000134607} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134607}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CT030728; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3UZR8; -. DR SMR; G3UZR8; -. DR PeptideAtlas; G3UZR8; -. DR PRIDE; G3UZR8; -. DR Ensembl; ENSMUST00000173629; ENSMUSP00000134607; ENSMUSG00000054128. DR MGI; MGI:95959; H2-T3. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000054128; Expressed in 15 organ(s), highest expression level in colon. DR ExpressionAtlas; G3UZR8; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|PeptideAtlas:G3UZR8}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 119 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003457235. FT DOMAIN 25 115 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 119 AA; 13503 MW; 289AC76895270CFA CRC64; MGTMVPGTLL ILLAASQGQT QTCPGSHSLR YFYTALSRPA ISEPWYIAVG YLDDTQFVRF NSSGETATYK LSAPWVEQEG PEYWARETEI VTSNAQFFRE NLQTMLDYYN LSQNGDVWL // ID G3V627_RAT Unreviewed; 339 AA. AC G3V627; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 64. DE SubName: Full=RT1 class Ib, locus M3, gene 1 {ECO:0000313|Ensembl:ENSRNOP00000000990}; DE SubName: Full=RT1 class Ib, locus M3, isoform CRA_a {ECO:0000313|EMBL:EDL84638.1}; GN Name=RT1-M3-1 {ECO:0000313|Ensembl:ENSRNOP00000000990, GN ECO:0000313|RGD:3494}; Synonyms=RT1-M3 {ECO:0000313|EMBL:EDL84638.1}; GN ORFNames=rCG_58606 {ECO:0000313|EMBL:EDL84638.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000000990, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000000990, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000000990, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|EMBL:EDL84638.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL84638.1}; RX PubMed=15632090; DOI=10.1101/gr.2889405; RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., RA Istrail S., Li P., Sutton G.; RT "Gene and alternative splicing annotation with AIR."; RL Genome Res. 15:54-66(2005). RN [3] {ECO:0000313|EMBL:EDL84638.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL84638.1}; RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., RA Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., RA Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSRNOP00000000990} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000000990}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC112568; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH474093; EDL84638.1; -; Genomic_DNA. DR RefSeq; NP_075210.2; NM_022921.2. DR UniGene; Rn.92606; -. DR STRING; 10116.ENSRNOP00000000990; -. DR Ensembl; ENSRNOT00000000990; ENSRNOP00000000990; ENSRNOG00000000763. DR GeneID; 24747; -. DR KEGG; rno:24747; -. DR CTD; 24747; -. DR RGD; 3494; RT1-M3-1. DR eggNOG; ENOG410KII2; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR KO; K06751; -. DR OMA; EYFRAYV; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000000763; Expressed in 10 organ(s), highest expression level in spleen. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0032398; C:MHC class Ib protein complex; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002287; P:alpha-beta T cell activation involved in immune response; IEA:Ensembl. DR GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; IEA:Ensembl. DR GO; GO:0002481; P:antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; IEA:Ensembl. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl. DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 339 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015290731. FT TRANSMEM 305 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 339 AA; 38135 MW; 76090EE4AB0D0A5A CRC64; MATSNKFSLL LMVVVALAVS RTGAGTHSLR YFHTALSRPG RGEPQYISVG YVDDKLFQRC DSVEEIPRME ARAPWMEKEG PEYWEELKLK VKSIAQRARA RLRTLIRYYN QSEGSSHILQ WMVACEVGPD MRLLGAHYQA AYDGSDYITL NEDLSSWTAA DMVAQITKSE LESEGRAEYF RAYVDGECLE LLHRFLQNGK EILQRADPPK AHVTLHPRPE GDVTLRCWAL GFYPADITLT WQLNGEDLTQ DMELVETKPS GDGTFQKWAS VVVPSGEEQK YTCHVEHEGL PEPLVLKWGG SSQSFVVIMV IIVIIVILAL LGGVLTVVLV YRRRGAGML // ID G3VAC9_SARHA Unreviewed; 397 AA. AC G3VAC9; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000000133}; GN Name=SAHAI-01 {ECO:0000313|Ensembl:ENSSHAP00000000133}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000000133}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000000133} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000000133} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01188340; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3VAC9; -. DR STRING; 9305.ENSSHAP00000000133; -. DR Ensembl; ENSSHAT00000000136; ENSSHAP00000000133; ENSSHAG00000000117. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3VAC9; -. DR OMA; SALTKTW; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 341 365 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 246 334 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 397 AA; 43986 MW; 6225EB220450B315 CRC64; MGWDLGVRRH LRFVVHSPGG TRSGGAPRAW PLTPGSRGRP HGVPALSPDR VPPSVSGSHS MRYFDTAVSR PGLGEPRFLA VGYVDDQQFV RFDSDSASQS EEPRAPWMEK VQDVDPGYWE RNTQISKENA QISRVDLQTL RGYYNQSEGA GAHTFQRMYG CEVSPELSFQ RGFLQFAYDG QDYIALDTET LTWTAAQNEA VNTKRKWEAE RSYAERDKAY LEETCVLWLK KYLEMGKESL QRADAPSARV TRHSTPSGEV TLQCRAQDFY PSEISLAWLR DGEEQHQDTE FIETRPAGDG TFQKWAAVGV PSGQEGRYTC RVQHEGLPEP LTLKWEPESS LPWIIVGVLA AVLLLTAVIA GAVVWRKKTS GGKGGDYVPA AGNDSAQGSD VSLTAKG // ID G3VAD0_SARHA Unreviewed; 340 AA. AC G3VAD0; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000000134}; DE Flags: Fragment; GN Name=SAHAI-01 {ECO:0000313|Ensembl:ENSSHAP00000000134}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000000134}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000000134} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000000134} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01188340; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSSHAT00000000137; ENSSHAP00000000134; ENSSHAG00000000117. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 285 309 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 190 278 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSSHAP00000000134}. SQ SEQUENCE 340 AA; 38030 MW; 766EAE0074E4A65B CRC64; SGSHSMRYFD TAVSRPGLGE PRFLAVGYVD DQQFVRFDSD SASQSEEPRA PWMEKVQDVD PGYWERNTQI SKENAQISRV DLQTLRGYYN QSEGGAHTFQ RMYGCEVSPE LSFQRGFLQF AYDGQDYIAL DTETLTWTAA QNEAVNTKRK WEAERSYAER DKAYLEETCV LWLKKYLEMG KESLQRADAP SARVTRHSTP SGEVTLQCRA QDFYPSEISL AWLRDGEEQH QDTEFIETRP AGDGTFQKWA AVGVPSGQEG RYTCRVQHEG LPEPLTLKWE PESSLPWIIV GVLAAVLLLT AVIAGAVVWR KKTSGGKGGD YVPAAGNDSA QGSDVSLTAK // ID G3VAD1_SARHA Unreviewed; 82 AA. AC G3VAD1; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000000135}; DE Flags: Fragment; GN Name=SAHAI-01 {ECO:0000313|Ensembl:ENSSHAP00000000135}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000000135}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000000135} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000000135} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01188340; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSSHAT00000000138; ENSSHAP00000000135; ENSSHAG00000000117. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}. FT DOMAIN 1 82 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSSHAP00000000135}. SQ SEQUENCE 82 AA; 9412 MW; ACB05E2BAE212242 CRC64; TAVSRPGLGE PRFLAVGYVD DQQFVRFDSD SASQSEEPRA PWMEKVQDVD PGYWERNTQI SKENAQISRV DLQTLRGYYN QS // ID G3VAD2_SARHA Unreviewed; 220 AA. AC G3VAD2; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000000136}; DE Flags: Fragment; GN Name=SAHAI-01 {ECO:0000313|Ensembl:ENSSHAP00000000136}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000000136}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000000136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000000136} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01188340; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSSHAT00000000139; ENSSHAP00000000136; ENSSHAG00000000117. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}. FT DOMAIN 150 220 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSSHAP00000000136}. SQ SEQUENCE 220 AA; 25154 MW; 2400C91334B0C85B CRC64; SASQSEEPRA PWMEKVQDVD PGYWERNTQI SKENAQISRV DLQTLRGYYN QSEGGAHTFQ RMYGCEVSPE LSFQRGFLQF AYDGQDYIAL DTETLTWTAA QNEAVNTKRK WEAERSYAER DKAYLEETCV LWLKKYLEMG KESLQRADAP SARVTRHSTP SGEVTLQCRA QDFYPSEISL AWLRDGEEQH QDTEFIETRP AGDGTFQKWA AVGVPSGQEG // ID G3VAD3_SARHA Unreviewed; 209 AA. AC G3VAD3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000000137}; DE Flags: Fragment; GN Name=SAHAI-01 {ECO:0000313|Ensembl:ENSSHAP00000000137}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000000137}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000000137} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000000137} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01188340; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSSHAT00000000140; ENSSHAP00000000137; ENSSHAG00000000117. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}. FT DOMAIN 143 209 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSSHAP00000000137}. SQ SEQUENCE 209 AA; 24064 MW; BBF32120ECF11809 CRC64; PRAPWMEKVQ DVDPGYWERN TQISKENAQI SRVDLQTLRG YYNQSEGGAH TFQRMYGCEV SPELSFQRGF LQFAYDGQDY IALDTETLTW TAAQNEAVNT KRKWEAERSY AERDKAYLEE TCVLWLKKYL EMGKESLQRA DAPSARVTRH STPSGEVTLQ CRAQDFYPSE ISLAWLRDGE EQHQDTEFIE TRPAGDGTFQ KWAAVGVPS // ID G3VAD4_SARHA Unreviewed; 133 AA. AC G3VAD4; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000000138}; DE Flags: Fragment; GN Name=SAHAI-01 {ECO:0000313|Ensembl:ENSSHAP00000000138}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000000138}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000000138} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000000138} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01188340; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSSHAT00000000141; ENSSHAP00000000138; ENSSHAG00000000117. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}. FT DOMAIN 1 133 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSSHAP00000000138}. SQ SEQUENCE 133 AA; 15636 MW; 7BFFD0592644AA68 CRC64; PRAPWMEKVQ DVDPGYWERN TQISKENAQI SRVDLQTLRG YYNQSEGGAH TFQRMYGCEV SPELSFQRGF LQFAYDGQDY IALDTETLTW TAAQNEAVNT KRKWEAERSY AERDKAYLEE TCVLWLKKYL EMG // ID G3VAD5_SARHA Unreviewed; 41 AA. AC G3VAD5; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000000139}; DE Flags: Fragment; GN Name=SAHAI-01 {ECO:0000313|Ensembl:ENSSHAP00000000139}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000000139}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000000139} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000000139} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01188340; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSSHAT00000000142; ENSSHAP00000000139; ENSSHAG00000000117. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}. FT DOMAIN 1 41 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSSHAP00000000139}. SQ SEQUENCE 41 AA; 4876 MW; 80A5EE0B67D175AB CRC64; PRAPWMEKVQ DVDPGYWERN TQISKENAQI SRVDLQTLRG Y // ID G3VGC5_SARHA Unreviewed; 361 AA. AC G3VGC5; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000002229}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000002229}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000002229} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000002229} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01181580; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3VGC5; -. DR STRING; 9305.ENSSHAP00000002229; -. DR Ensembl; ENSSHAT00000002253; ENSSHAP00000002229; ENSSHAG00000001982. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3VGC5; -. DR OMA; DWARYDC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 361 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003457806. FT TRANSMEM 307 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 361 AA; 41420 MW; F44DB119CD337E97 CRC64; MEHYMLFLFF LAALTQTETW AGCHTMKYFD TIVTGPSLGL EERWFMTVGY VDDQQFVRFH NSSGSQITEP RAPWIELETP DYWERETRHL KDSQHCPMSL QNLHFNYNQS DDGGVHTLQR MYGCEVFPNG SFSTFFLRYG YDGQDKLSLD PETVIWIASD QVALNLKLKL ETDRSLAERW EVYLKETCVQ ELLRHLEKGK KTHYPLDPPS VRVTRHITSD REVFLKCRAW GFYPSEISII WLKDGEEQIQ DTEYIETRPG GDGTFQKWAA VEMPFRNEEK YTCLIQHEGL PAPLSLKWEP QSTSNGLFMG IIAAVLLLFT AVVAGVVIWK KSTLGGKGRN YALTSEIDSA QGSDVSLTAR G // ID G3VGQ3_SARHA Unreviewed; 341 AA. AC G3VGQ3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000002357}; GN Name=LOC105749194 {ECO:0000313|Ensembl:ENSSHAP00000002357}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000002357, ECO:0000313|Proteomes:UP000007648}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000002357} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000002357} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01040802; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AEFK01040803; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AEFK01040804; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_012396265.1; XM_012540811.1. DR ProteinModelPortal; G3VGQ3; -. DR Ensembl; ENSSHAT00000002382; ENSSHAP00000002357; ENSSHAG00000002090. DR GeneID; 105749194; -. DR KEGG; shr:105749194; -. DR eggNOG; ENOG410IZF6; Eukaryota. DR eggNOG; ENOG41119ST; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; ADWISEV; -. DR TreeFam; TF352056; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 341 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003457522. FT TRANSMEM 308 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 341 AA; 39172 MW; 7509E7B960D23136 CRC64; MMNWRRESGS FSSWLLILVV LFALRGIQTG HHKNEIKHIA VGTSKTLLDL TVVALIDDIW WASYFKSNQH MVFKADWISE VLGSNLIEEM EHLLINHKED FQFVFHYLTR NDTETEGNHT LQIQLDCELD GDIQLSSHVK YAFDGEDLIK VDELEGQWVV LNPKARNFKL IVNSPFWTEV RKRYIKRYCV GAMQKIIGNS NMKKNESPEV YVSQQDYPDG TTKLSCTATG FYPQPILLHW KKGTDGAIWG KESSSGTLPN SDDTFYLRIS LEIQPGDSVT DYACIVEHSE LERPVVYPVP KKPYKKNFWV VALSILLGVI LTVGCLVVFI QWKKRKSGMY C // ID G3VJJ0_SARHA Unreviewed; 381 AA. AC G3VJJ0; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000003345}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000003345}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000003345} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000003345} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01183470; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3VJJ0; -. DR STRING; 9305.ENSSHAP00000003345; -. DR Ensembl; ENSSHAT00000003381; ENSSHAP00000003345; ENSSHAG00000002942. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3VJJ0; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 327 349 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 230 318 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 188 208 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 381 AA; 43133 MW; CC35567A274337E4 CRC64; MKEKVAAVEA AARIPRWNEF SAFATEAGPG SLGLGGQSWL WSLSLGVHSL RYFQTSMSQP GLTKPRFISV GYVDDQAFVR FDSDSAGLRE EPMVMWLDKS NQNYWERNSR VIWETARTFQ VGLQNLQFYY NQSEGAHTYQ RLVGCEVTYD WIFLRGFEQF AYNGHDYISL DLTTLSWTVA EPTALNSKLK WEAERSIAQR QKEYLEEKCV YWLRKYLEYG KEKLLRAAPP SVRITHRTHP DGKVTLQCRS QDFYPAEISL TWLRDGEEQH QDTEFIETRP AGDGTFQKWV AVEVTSGQEG NYICRVQHEG LPEPLTLKWE PESSSPWIIV GVLAAVFLLN AVIAGAVVWR KKTSGGKGGD YVQAAGNDSA QGSDVSLTAK A // ID G3VK11_SARHA Unreviewed; 244 AA. AC G3VK11; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000003516}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000003516}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000003516} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000003516} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01040805; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3VK11; -. DR Ensembl; ENSSHAT00000003552; ENSSHAP00000003516; ENSSHAG00000003088. DR eggNOG; ENOG410IZF6; Eukaryota. DR eggNOG; ENOG41119ST; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3VK11; -. DR OMA; QYLTHEC; -. DR OrthoDB; EOG090B0CDR; -. DR TreeFam; TF352056; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 215 238 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 115 196 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 244 AA; 27793 MW; 245D4809849710E6 CRC64; MNFSWFLKFL IQNDTKKESS LSTENHTMQL FIDCELNSGI EVGSRIWFAL DGEDFLKTDD QTNHWTAMKP EAEHIKYMAE SYFGVKMRDR TIKIYCYDMM RKILEYSSMK ENVAPEVTVT RHDAPDGRVT FNCIATGFYP RSIQLLWKKD EQLGVWGQES SSGTLPNADS TFYLQITLEL PPGDSGTGYS CVVEHSKLQK PDLVVPEKPA VKRPWGMALG LLTIIMLLLG CAGPFIIWKK KKTG // ID G3VLU3_SARHA Unreviewed; 228 AA. AC G3VLU3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000004148}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000004148, ECO:0000313|Proteomes:UP000007648}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000004148} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000004148} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01041463; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3VLU3; -. DR Ensembl; ENSSHAT00000004189; ENSSHAP00000004148; ENSSHAG00000003654. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}. FT DOMAIN 30 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 228 AA; 26820 MW; F1035DE39307423B CRC64; MGNWKKRGGS LSSWKLVLVI FVLKEVQTGQ HRHEFYFTAV GTTGSLLNFT MVSFIDDIQL CSYHKRNQIS GMMECIPSIL SANFSEQMQS ALMKHEEDFH RLICYLEQND TQSEESHILQ LFVDCHLEDD IQMDSHVQLA WDGEDLSRID EQQGYWIFLK PMGYSLKRGL ESAFWETVRK NYMQEYCYDI MRRILRYSRI KENGESHPSL IFSQEKQISS MLLLWSSS // ID G3VLX9_SARHA Unreviewed; 282 AA. AC G3VLX9; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000004184}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000004184, ECO:0000313|Proteomes:UP000007648}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000004184} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000004184} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01164963; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3VLX9; -. DR STRING; 9305.ENSSHAP00000004184; -. DR Ensembl; ENSSHAT00000004225; ENSSHAP00000004184; ENSSHAG00000003686. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3VLX9; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 237 263 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 144 182 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 282 AA; 32924 MW; 3BBD6927A9B1E37A CRC64; LFVYYDHESQ KAKLQDPWMQ KKDKFWMRLT QSLKGWDHIF FVDHNGQSQS RILQKVIFSC ELLMEDNRTR SFWNYGYDDQ DYLLFHQEIM NWTAVQSKSQ ATKQELEMNK IRAKQHRAYL ESDFPEYLQE YILSLQIAVL SVTPLVRVTR HATHKGTITL RCQALNFSPM TITLSWLWDG KQLNQGIQLG DIYPSEDETF QVWTAVDITP GEEQRYAYQI EHMGLINPSL CLGHGPLSVT LATGISTGII VSIIIITTVV IIWKKRNMSR GLIRNYILAE DK // ID G3VML5_SARHA Unreviewed; 223 AA. AC G3VML5; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000004420}; DE Flags: Fragment; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000004420, ECO:0000313|Proteomes:UP000007648}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000004420} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000004420} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01040806; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3VML5; -. DR Ensembl; ENSSHAT00000004466; ENSSHAP00000004420; ENSSHAG00000003889. DR eggNOG; ENOG410IZF6; Eukaryota. DR eggNOG; ENOG41119ST; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 194 217 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 85 185 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSSHAP00000004420}. SQ SEQUENCE 223 AA; 24924 MW; 528D13B3E692C9C4 CRC64; NHTVQIFALC EIESDSHIGN EIQIAVDGHE FSVLDDEMGL WIALMSEAQS FLPVLTSTLW TTQRELYMQE YCIDTMKKIL QHSGPCIISS VPPEVTVSQY ETVDGITTLS CSATGFYPRS ILLHWQNGKN IIMAGKQSSS GVLPNADSTF YQRITIELLP EDMGTDYDCV VDHIELGPPK AYPIQVKYPK KRSWTVTITI LSVVILVLSC TASFIVWKKM KTG // ID G3VML6_SARHA Unreviewed; 270 AA. AC G3VML6; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000004421}; DE Flags: Fragment; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000004421, ECO:0000313|Proteomes:UP000007648}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000004421} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000004421} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01040806; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3VML6; -. DR Ensembl; ENSSHAT00000004467; ENSSHAP00000004421; ENSSHAG00000003889. DR eggNOG; ENOG410IZF6; Eukaryota. DR eggNOG; ENOG41119ST; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3VML6; -. DR OMA; YLEGICI; -. DR OrthoDB; EOG091G1FFE; -. DR TreeFam; TF352056; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}. FT DOMAIN 184 270 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSSHAP00000004421}. SQ SEQUENCE 270 AA; 30498 MW; 054FEC671DB44943 CRC64; GVHEMQYGVC SHALVRSGLG KPSCLPMDFL DDVQVLSYDK HTQQLKAKED WVVQALGAKF IAKTQQKLLD HEKDFLWFLK KLMLNETKRD VNHTVQIFAL CEIESDSHIG NEIQIAVDGH EFSVLDDEMG LWIALMSEAQ SFLPVLTSTL WTTQRELYMQ EYCIDTMKKI LQHSVINFLP SVPPEVTVSQ YETVDGITTL SCSATGFYPR SILLHWQNGK NIIMAGKQSS SGVLPNADST FYQRITIELL PEDMGTDYDC VVDHIELGPP // ID G3VNZ2_SARHA Unreviewed; 328 AA. AC G3VNZ2; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000004897}; DE Flags: Fragment; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000004897, ECO:0000313|Proteomes:UP000007648}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000004897} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000004897} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01041466; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3VNZ2; -. DR Ensembl; ENSSHAT00000004946; ENSSHAP00000004897; ENSSHAG00000004293. DR eggNOG; ENOG410IZF6; Eukaryota. DR eggNOG; ENOG41119ST; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3VNZ2; -. DR OMA; NETEKTH; -. DR OrthoDB; EOG091G0HHE; -. DR TreeFam; TF352056; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 282 305 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 180 270 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSSHAP00000004897}. SQ SEQUENCE 328 AA; 37460 MW; F7886EBEAB1CEABF CRC64; SAHHSHDFHF TAIGRATSLL NFTVISSVDD VQLCYYNKQD QQVVMKKAWM YEALGAAEIE RKQKKLISLE KTFQWAFRSL IKNETEKTHM LQVFVDCEVD RDVQVSSHFQ FALDGEDFCQ MDEQLGHWVA MKPEAQRFKP LWDSALWKRQ VKHFLQEDCV DSMTKVLQYS SMSSLPSVPP EVTVSRHDAP DDGRVTLFCR ATGFYPRSIT LHWEREGALG VWGQESSSGI LPNADATFYL RVTLELPPSD PGTGYTCVVE HSELETPAVF PVPGKPPMER PWTIVLSTAA VIILVLSCAG AFIIWKKRKA GVYVWREGKE QEREIMRE // ID G3VP00_SARHA Unreviewed; 285 AA. AC G3VP00; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000004905}; GN Name=LOC105749196 {ECO:0000313|Ensembl:ENSSHAP00000004905}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000004905, ECO:0000313|Proteomes:UP000007648}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000004905} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000004905} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01040806; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AEFK01040807; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_012396268.1; XM_012540814.1. DR ProteinModelPortal; G3VP00; -. DR Ensembl; ENSSHAT00000004954; ENSSHAP00000004905; ENSSHAG00000004299. DR GeneID; 105749196; -. DR KEGG; shr:105749196; -. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3VP00; -. DR OrthoDB; EOG091G1JIW; -. DR TreeFam; TF352056; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 255 277 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 153 240 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 285 AA; 32727 MW; E6785B51E4C12F6C CRC64; MDDIEVGSYN SADQQITVKI PWISQVIEAD YTNQIHHILV AHEQNTHWLM QFLSNNDTNH NRNHTAQLLA ECEIDNDIKI KSRIHLIWEG EEYYRIDEEV GQWENLKPEV KKLQYILDSP FWTNLRKNYM NEYCVNLLRK IVGYSSLRDN VPPEVTVSRH VNPEGRIILS CTATGFYPRS ILLQWKKNGE LGVWGKETSS GILPNMDSTF YLRLTLELPP EDSGTGFTCV VEHTELKTPA VYPVPEKPTL KKPPVLTVSI VLAVILVMSC AGAFIAWKKR KSCMQ // ID G3VPX8_SARHA Unreviewed; 332 AA. AC G3VPX8; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000005233}; DE Flags: Fragment; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000005233, ECO:0000313|Proteomes:UP000007648}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000005233} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000005233} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01041466; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3VPX8; -. DR Ensembl; ENSSHAT00000005285; ENSSHAP00000005233; ENSSHAG00000004579. DR eggNOG; ENOG410IZF6; Eukaryota. DR eggNOG; ENOG41119ST; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3VPX8; -. DR OMA; ECKLEAN; -. DR OrthoDB; EOG090B0CDR; -. DR TreeFam; TF352056; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 282 305 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 179 268 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSSHAP00000005233}. SQ SEQUENCE 332 AA; 37671 MW; 29915215C6F72C83 CRC64; HTLEMCFTAV GTTKSLLDFT MVSSMDGVQG SFYDKKDQQL VIKEAWVSQA LGAHYIEKKR QKLVFSEINF LWALQNWIQN DIKGEDNHTV QFWHDCHLDG DIHVSSHFWY AVDGEAFCGV DEQLRHWVAM KPEAECFKPF WEMIFPYKKI KHYMQEDCVE PLRKVLKYSQ TSSLPSVPPE VTVLRHDAPD DSRVTLFCRA TGFYPRSITL HWERDGALGV WGQESSSGIL PNADATFYLQ VTLELPPSDP GTGYTCVVEH SELETPVIFP EVPEKPSMER RWAMALSILA TVILVLSCAG AFNIWREKKA GTYDDLTANG NSNADDGDVI PI // ID G3VQS7_SARHA Unreviewed; 366 AA. AC G3VQS7; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000005532}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSSHAP00000005532}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000005532, ECO:0000313|Proteomes:UP000007648}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000005532} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000005532} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01124044; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3VQS7; -. DR STRING; 9305.ENSSHAP00000005532; -. DR Ensembl; ENSSHAT00000005586; ENSSHAP00000005532; ENSSHAG00000004834. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3VQS7; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 308 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 40097 MW; F7E691BBA5155D7E CRC64; VSSPCLSPIL VGLAFSGCPR GSLGPGLGPA GTPSLFYQLT AVSSAPRGTP KVWGSGWLGP QLFLTYSSGG NAEPWGAWRW EPQEAWFWEE ETWYLKKQER LLQEALRVSK EGAQIFQGLM GCQLKPDNSS QPTARFALDG ADLLTFDPTR RDWFGHSVEA SNVRNNWLNE SQLAEKVAEF LLITCPQRLK SHLQRGKHNF QWKEAPEVRA GSHVGPGAVW STLSCQAFFF FPPELELKFF REGKPVAELS PGLEPWPNGD GTFHSRGTLQ VPSGDEALYS CTVQHPALTE SITVNFETPG RLPLPVRVSL VAGSVLFLAC LAAVVACMIY RKRGGRPALW IFRRRRAGDD VGALLSAPGS AQDSSS // ID G3VYX3_SARHA Unreviewed; 321 AA. AC G3VYX3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000008378}; DE Flags: Fragment; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000008378, ECO:0000313|Proteomes:UP000007648}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000008378} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000008378} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01034782; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3VYX3; -. DR Ensembl; ENSSHAT00000008446; ENSSHAP00000008378; ENSSHAG00000007260. DR eggNOG; ENOG410KEP1; Eukaryota. DR eggNOG; ENOG4111939; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3VYX3; -. DR OrthoDB; EOG091G1FPA; -. DR TreeFam; TF352056; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 293 316 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 192 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSSHAP00000008378}. SQ SEQUENCE 321 AA; 37205 MW; 650D90EE7E3F5E41 CRC64; IFSSSLPSHN SVHHRYVGQF TAVGTYYSLL ELSAISFMDE VEVGFYNKEN QQLIIKIPWL TEALGDAYII QKRNLLVYHE QHFRWMMHFL AMNDTNHNRN HTVQLLADCE IDNDIKVKSY IHIIWDGEEI YRIDEEVGQW EYLKPEAKQY QHILESPFWT DLRKRYMNQF CVDFMKKIMG YKSIRILIPV PPEMTVSYRV NTEGSIILSC TATGFYPRSI QLQWEKNGEL GVWGKETSTG ILPNMDSTFY LRLTLELPPE DPGMNFTCVV EHVALKTPAL YSVPGKLTKE KSFFLALGIV LAVILLLSCA GAFIVWKKRC T // ID G3W4P6_SARHA Unreviewed; 337 AA. AC G3W4P6; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 44. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSSHAP00000010401}; GN Name=MR1 {ECO:0000313|Ensembl:ENSSHAP00000010401}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000010401, ECO:0000313|Proteomes:UP000007648}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000010401} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000010401} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01156363; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AEFK01156364; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AEFK01156365; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3W4P6; -. DR STRING; 9305.ENSSHAP00000010401; -. DR Ensembl; ENSSHAT00000010494; ENSSHAP00000010401; ENSSHAG00000008980. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3W4P6; -. DR OMA; GYVDSHP; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 293 312 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 337 AA; 39097 MW; 02681F89E644199E CRC64; MTVAIQEGHA RTHSLRYFRL GVSDSTQGIP EFISVGYVDS HPITSYDSIR RQKMPQASWM EENLGSDHWE KYTQLLRGWQ QTFKTELRVL QNHYNHTGGF HTYQRMIGCE LLEDGSTTGF LQYAYDGKDF LIFDKDSLSW IAVDNVARLT KQVWETNLNE LRYQKNWLET ECIAWLKKFL DFGKDSFQRT ENPLLRGSCK KSSLGITTLI CRAYGFYPPE ITMTWIKNGE LIIQEIEYGD ILPSGDGTYQ TWISIEIDPQ SKDHYFCQVE HNDFLKVLHV PIEPKTISPF VEIISGFTVI VLFLIGLGIF VYRRKQSGIK EANYIPTPVK KYRTNPS // ID G3WAY4_SARHA Unreviewed; 364 AA. AC G3WAY4; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000012589}; DE Flags: Fragment; GN Name=SAHAI-12 {ECO:0000313|Ensembl:ENSSHAP00000012589}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000012589}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000012589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000012589} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01166366; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3WAY4; -. DR STRING; 9305.ENSSHAP00000012589; -. DR Ensembl; ENSSHAT00000012693; ENSSHAP00000012589; ENSSHAG00000010776. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; G3WAY4; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003458525. FT TRANSMEM 310 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 213 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 164 191 {ECO:0000256|SAM:Coils}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSSHAP00000012589}. SQ SEQUENCE 364 AA; 40636 MW; C4AB06D79E266FFA CRC64; LPTMGSYACS LFLLGALALK ETWEGSHSLR YFGTTVSRPG LGEPRFFSVG YVDDQQFVGF DSDSASQRVE PRAPWIEKME NVDRDYWERN TQNSKRNAQI SREDLQTLHG YYNQSESGVH TFQRLVGCEI SPDLSFKRGF DQYAYDGQDY LALDTETLTW TAAVNEAVNS KHKLEAERSN AERDKAYLEE TCVLWLKMYL EMGKESLQRA DPPSVQVTRH STSNGEVTLQ CRAQDFYPAE ISLTWLRDGE EQHQDTEFIE TRPAGDGTFQ KWAAVGVTSG QEGKYTCRVQ HEGLPEPLIL KWEPESSSPW IIVGILAVAV FLLTVVIAGA VVWRKKTSGG KGGDYVLAAG SDSAQGSDVS LSAK // ID G3WAY6_SARHA Unreviewed; 228 AA. AC G3WAY6; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000012591}; DE Flags: Fragment; GN Name=SAHAI-12 {ECO:0000313|Ensembl:ENSSHAP00000012591}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000012591}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000012591} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000012591} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01166366; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSSHAT00000012695; ENSSHAP00000012591; ENSSHAG00000010776. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}. FT DOMAIN 144 228 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 95 122 {ECO:0000256|SAM:Coils}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSSHAP00000012591}. SQ SEQUENCE 228 AA; 26247 MW; 4C48AF223B5B6698 CRC64; EPRAPWIEKM ENVDRDYWER NTQNSKRNAQ ISREDLQTLH GYYNQSESGV HTFQRLVGCE ISPDLSFKRG FDQYAYDGQD YLALDTETLT WTAAVNEAVN SKHKLEAERS NAERDKAYLE ETCVLWLKMY LEMGKESLQR ADPPSVQVTR HSTSNGEVTL QCRAQDFYPA EISLTWLRDG EEQHQDTEFI ETRPAGDGTF QKWAAVGVTS GQEGKYTCRV QHEGLPEP // ID G3WAY7_SARHA Unreviewed; 258 AA. AC G3WAY7; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000012592}; GN Name=SAHAI-12 {ECO:0000313|Ensembl:ENSSHAP00000012592}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000012592}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000012592} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000012592} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01166366; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSSHAT00000012696; ENSSHAP00000012592; ENSSHAG00000010776. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 258 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003458560. FT DOMAIN 210 258 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 161 188 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 258 AA; 29632 MW; E165D238875E8325 CRC64; MGSYACSLFL LGALALKETW EGSHSLRYFG TTVSRPGLGE PRFFSVGYVD DQQFVGFDSD SASQRVEPRA PWIEKMENVD RDYWERNTQN SKRNAQISRE DLQTLHGYYN QSESGVHTFQ RLVGCEISPD LSFKRGFDQY AYDGQDYLAL DTETLTWTAA VNEAVNSKHK LEAERSNAER DKAYLEETCV LWLKMYLEMG KESLQRADPP SVQVTRHSTS NGEVTLQCRA QDFYPAEISL TWLRDGEEQH QDTEFIET // ID G3WAY8_SARHA Unreviewed; 82 AA. AC G3WAY8; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000012593}; DE Flags: Fragment; GN Name=SAHAI-12 {ECO:0000313|Ensembl:ENSSHAP00000012593}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000012593}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000012593} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000012593} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01166366; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSSHAT00000012697; ENSSHAP00000012593; ENSSHAG00000010776. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}. FT DOMAIN 1 82 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSSHAP00000012593}. SQ SEQUENCE 82 AA; 9602 MW; 444429F79FE4FE56 CRC64; TTVSRPGLGE PRFFSVGYVD DQQFVGFDSD SASQRVEPRA PWIEKMENVD RDYWERNTQN SKRNAQISRE DLQTLHGYYN QS // ID G3WSI9_SARHA Unreviewed; 322 AA. AC G3WSI9; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000018394}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000018394, ECO:0000313|Proteomes:UP000007648}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000018394} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000018394} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01109326; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3WSI9; -. DR Ensembl; ENSSHAT00000018546; ENSSHAP00000018394; ENSSHAG00000015612. DR eggNOG; ENOG410J8UC; Eukaryota. DR eggNOG; ENOG4111ECF; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3WSI9; -. DR OMA; LVLQSHW; -. DR OrthoDB; EOG091G0VOG; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 322 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003459551. FT DOMAIN 205 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 322 AA; 36544 MW; 6804274BE8CA74EC CRC64; MAPEKQNKNL SDSLLFLFLL GSLANAQSHI LQYNVFVTVI DGELLFSVLG YLNDELFFYY DSKSQTPEPR GIWLDSIMKT DTWKTENSNV KEIIKAFRII MGKVMEQSDQ NTDSHTFQEI LGCELHKDGS IRGFLRFGYD GEDFLIFHSE TLTWEAVHPA ARSLENAFEA EPVETKIQKA KLEGDYCAGL QGYLEVWKEE KPVFPSLNLT QSKNPKEIIT LKCRVYNFFP GDIKIMWYRN GDTLSQRDQE GGIILPSGDG TYQTWVSTDV YSEKSNYTCH GEHQGRNQST SISLGPVSEA NRKYGIPPAL FFGVFVAAVH MV // ID G3WY07_SARHA Unreviewed; 190 AA. AC G3WY07; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000020312}; GN Name=LOC105750241 {ECO:0000313|Ensembl:ENSSHAP00000020312}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000020312, ECO:0000313|Proteomes:UP000007648}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000020312} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000020312} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01011640; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_012402835.1; XM_012547381.1. DR ProteinModelPortal; G3WY07; -. DR Ensembl; ENSSHAT00000020473; ENSSHAP00000020312; ENSSHAG00000017227. DR GeneID; 105750241; -. DR KEGG; shr:105750241; -. DR GeneTree; ENSGT00740000115973; -. DR OMA; EREACPR; -. DR OrthoDB; EOG091G1FPA; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 190 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003459561. FT DOMAIN 38 189 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 190 AA; 22144 MW; 0727432182FE9543 CRC64; MMGALVTVFF LLFFSGTVLG QDCDSLMYRD LISSKPQFSF RNTAYFNGER VYQYDSNNQK AVPEPEWKNV QDWDKESQIQ KQRGDFAIET LKEIMNSSKK ERDSHVLNGR IKCELCQNNA TSGSWSYAYD GNPFIRFDKD KVAWIAEQPA ATVIKQKWEE NPGAVNRTKE YLEKECIETL KKFRDYKKAN // ID G3WY24_SARHA Unreviewed; 298 AA. AC G3WY24; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 20-JUN-2018, entry version 50. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000020329}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000020329}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000020329} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000020329} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEFK01011641; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3WY24; -. DR Ensembl; ENSSHAT00000020490; ENSSHAP00000020329; ENSSHAG00000017241. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; G3WY24; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 298 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003459248. FT DOMAIN 208 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 298 AA; 34182 MW; 54B2D0C744CCD5CD CRC64; MMGSLTTIFI LLLFMDTTMS KKSGARCYTL IYQDTALSHP GPEEFSFTNT GYLNGQAFYQ YDSKSQKAIP LSPWDKVEGM NDWEKESQLQ KRREDFVLEN MQNITDYYND GKGSHIFQGR FGCQLCGDNF AKGFWKCQYD GRDFIEFKTT EIPAWIPLDP AADVIKQRWE ADPGAVYRAK AYLEEECIGT LRTYLELGKA YLHQLIPPKV NLSHYSAPGG NLVLECLAYD FYPREIELHW LQDGKIQKKE VGQTQIIGNG TYQVSITVNI PLLKKKSYSC HVVHESLPEA FIVAWDEE // ID G3X6N1_BOVIN Unreviewed; 212 AA. AC G3X6N1; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000009522}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000009522, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000009522, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000009522, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000009522} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000009522}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02048565; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3X6N1; -. DR STRING; 9913.ENSBTAP00000009522; -. DR PaxDb; G3X6N1; -. DR Ensembl; ENSBTAT00000009522; ENSBTAP00000009522; ENSBTAG00000007238. DR eggNOG; ENOG410JBPA; Eukaryota. DR eggNOG; ENOG411150N; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G3X6N1; -. DR OMA; HLEREVN; -. DR OrthoDB; EOG091G0NI5; -. DR TreeFam; TF339658; -. DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000009136; Chromosome 19. DR Bgee; ENSBTAG00000007238; Expressed in 8 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 212 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003459464. FT DOMAIN 33 205 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 212 AA; 23906 MW; F4F352520A0B8B64 CRC64; ARRQRYRHTP GYLLLVTLLK LQGGMSLAQT TDAHSLCLDL TVKSQSRPGQ PWCQVQGSVD TKPFLWYDSD SNKVKPLGFL GKEVNDTKAW TEISQTLVAA GRELRMVLPV IKLDKRGTGP PTLQVKLCCQ REAEQCSGAS LNFSLDGQTA LLLDTMSITW TVIDPGATGI KEEWENNQEL AEYFRTISTG DCSYWLWEFL KHWEKMLVPE PT // ID G3X7K3_BOVIN Unreviewed; 242 AA. AC G3X7K3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 12-SEP-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000033925}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000033925, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000033925, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000033925, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000033925} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000033925}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02048557; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02048558; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02048559; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02048560; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9913.ENSBTAP00000033925; -. DR PaxDb; G3X7K3; -. DR Ensembl; ENSBTAT00000034023; ENSBTAP00000033925; ENSBTAG00000024490. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G3X7K3; -. DR OMA; EANGHTH; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Reactome; R-BTA-163125; Post-translational modification: synthesis of GPI-anchored proteins. DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000009136; Chromosome 19. DR Bgee; ENSBTAG00000024490; Expressed in 6 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 242 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003459764. FT DOMAIN 26 196 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 242 AA; 27405 MW; 87797AA370899125 CRC64; MGGSKSSLDF LVLLLIVLFS GTSSDAHSLS YNVTIDPRPR DGQPWCEVQG EVDQKVFLSY DCGRAKIKSI SPLGEEVKSM NAWETQINTL KDTGDLLKEQ MPDVTPEKHI DKGPLTLQAR MTCWREDNGH TSASWEFGFN GQLCLLFDSE NGYWTMVHSK GRRMKEKWEN DRAVMDFFKK VSMGDCQRWY HTFLVRWEKM LKTAASPTEA PLRVNSTATA TKHVTCILPV LLSSFIITVF LG // ID G5AN09_HETGA Unreviewed; 315 AA. AC G5AN09; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 20-JUN-2018, entry version 28. DE SubName: Full=Zinc-alpha-2-glycoprotein {ECO:0000313|EMBL:EHA98419.1}; GN ORFNames=GW7_15792 {ECO:0000313|EMBL:EHA98419.1}; OS Heterocephalus glaber (Naked mole rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Heterocephalus. OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA98419.1, ECO:0000313|Proteomes:UP000006813}; RN [1] {ECO:0000313|EMBL:EHA98419.1, ECO:0000313|Proteomes:UP000006813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993625; DOI=10.1038/nature10533; RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L., RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X., RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A., RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., RA Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L., RA Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.; RT "Genome sequencing reveals insights into physiology and longevity of RT the naked mole rat."; RL Nature 479:223-227(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH166116; EHA98419.1; -; Genomic_DNA. DR ProteinModelPortal; G5AN09; -. DR InParanoid; G5AN09; -. DR Proteomes; UP000006813; Unassembled WGS sequence. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006813}; KW Reference proteome {ECO:0000313|Proteomes:UP000006813}. FT DOMAIN 210 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 315 AA; 36136 MW; CF63EC602029C115 CRC64; MRGTVKITAS PVNTMKQPAG GARSHSITSP YSLTFLYTGL SRPSRVLPRF QATAFLNDQA FFHYNSDSRK AEPLGPWRQI KGMEDWEKES QLQKAREEIF LVTLKDIMDY YKDREGSHTL QGMFSCEIQN NRSSAAFWRY AYDGQDFIEF NKEIPAWVPL HPAAWKTKQK WEAEKVYLQR AKAYLEEECP RMLRRYLNYS KAHLDRQDSP SVSVTGYSVP GRNKTLKCLA SDFYPPEIGL RWIHAGKKRE SESRVDVLPS GNGTYQSWVV VEIPPHDRGP HFCLVEHSGL AQSLTVPWEE KQKAGAEGNV ETQPQ // ID G5BKK8_HETGA Unreviewed; 338 AA. AC G5BKK8; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 20-JUN-2018, entry version 34. DE SubName: Full=Major histocompatibility complex class I-related gene protein {ECO:0000313|EMBL:EHB09819.1}; GN ORFNames=GW7_08682 {ECO:0000313|EMBL:EHB09819.1}; OS Heterocephalus glaber (Naked mole rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Heterocephalus. OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB09819.1, ECO:0000313|Proteomes:UP000006813}; RN [1] {ECO:0000313|EMBL:EHB09819.1, ECO:0000313|Proteomes:UP000006813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993625; DOI=10.1038/nature10533; RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L., RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X., RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A., RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., RA Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L., RA Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.; RT "Genome sequencing reveals insights into physiology and longevity of RT the naked mole rat."; RL Nature 479:223-227(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH170762; EHB09819.1; -; Genomic_DNA. DR RefSeq; XP_004853403.1; XM_004853346.2. DR ProteinModelPortal; G5BKK8; -. DR GeneID; 101700189; -. DR KEGG; hgl:101700189; -. DR InParanoid; G5BKK8; -. DR Proteomes; UP000006813; Unassembled WGS sequence. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006813}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006813}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 338 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003474466. FT TRANSMEM 293 319 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 278 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 338 AA; 39213 MW; 78C14FD9BF0CEE14 CRC64; MVILLPLLTV LMVKFTHART HSLRYFRLGL SDPSHGVPEF ISVGYVDSHP ITTYDSVTRQ KEPRASWMAE NLAPDHWDRY TQLLRGWQQT FKMELRHLQR HYNHSGFHTY QRMIGCELLE DGSTTGFLQY AYDGQDFIIF NKDTLSWVAI DNVAHITKRA WEANQHELQY QKNWLEKECI AWLRRFLEYG KDTLQRTEPP LVRTNRQEIL PGITTLFCRA HGFYPPEISM MWMKNGEEIV QEVDYGDILP SGDGTYQTWV SIELDPQSSD IYSCHVEHCG LQMVIQASQE PKIIFLMTKA VPVAIGLAIV LAGVGILAWR RRLRGKNEVI YHPTSSDQ // ID G5BQE5_HETGA Unreviewed; 367 AA. AC G5BQE5; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 25-OCT-2017, entry version 34. DE SubName: Full=Hereditary hemochromatosis protein-like protein {ECO:0000313|EMBL:EHB11506.1}; GN ORFNames=GW7_13931 {ECO:0000313|EMBL:EHB11506.1}; OS Heterocephalus glaber (Naked mole rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Heterocephalus. OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB11506.1, ECO:0000313|Proteomes:UP000006813}; RN [1] {ECO:0000313|EMBL:EHB11506.1, ECO:0000313|Proteomes:UP000006813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993625; DOI=10.1038/nature10533; RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L., RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X., RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A., RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., RA Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L., RA Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.; RT "Genome sequencing reveals insights into physiology and longevity of RT the naked mole rat."; RL Nature 479:223-227(2011). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH171342; EHB11506.1; -; Genomic_DNA. DR ProteinModelPortal; G5BQE5; -. DR InParanoid; G5BQE5; -. DR Proteomes; UP000006813; Unassembled WGS sequence. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 2. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006813}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006813}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 367 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003474676. FT TRANSMEM 323 345 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 226 315 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 367 AA; 41173 MW; 7AF13D8F2B9D4B74 CRC64; MCAWAGSALL LLLFMQTAAP QGRPLRSHTL RYLFMCASEP ELGLPLFEAL GYVDDQLFVS YNGESRRAEP RAQWIGRTSS RMWLQLSQSL KGWEHMFILD FWTIVDNHNH SKGMVGTGTY SSGFSNELGV LPESHTLQVI FGCEVQEDNS TRGFWKYGYD GQDHLDFCPE TLDWKAAEPA AHPTKLEWEK NKIREKQNKA YLEKDCPGQL QKFLELGKGI LDQPVPPLAK VTHHVAPAAT TLQCQALRFY PQNITMRWLK DKQLLDAKEG GQKDVLPNGD GTYQGQVVLS VPLGEEQRYT CLVEHEGLDH PLTATWEPSP SSALVIGVSS GIIVCVIIFF TGILFRTLRK KQASRGAIQD YVLAGCE // ID G5C3D6_HETGA Unreviewed; 259 AA. AC G5C3D6; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 28-FEB-2018, entry version 33. DE SubName: Full=Class I histocompatibility antigen, GOGO-OKO alpha chain {ECO:0000313|EMBL:EHB16047.1}; DE Flags: Fragment; GN ORFNames=GW7_04766 {ECO:0000313|EMBL:EHB16047.1}; OS Heterocephalus glaber (Naked mole rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Heterocephalus. OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB16047.1, ECO:0000313|Proteomes:UP000006813}; RN [1] {ECO:0000313|EMBL:EHB16047.1, ECO:0000313|Proteomes:UP000006813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993625; DOI=10.1038/nature10533; RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L., RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X., RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A., RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., RA Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L., RA Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.; RT "Genome sequencing reveals insights into physiology and longevity of RT the naked mole rat."; RL Nature 479:223-227(2011). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH173151; EHB16047.1; -; Genomic_DNA. DR ProteinModelPortal; G5C3D6; -. DR InParanoid; G5C3D6; -. DR Proteomes; UP000006813; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006813}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000006813}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 208 229 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 105 193 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:EHB16047.1}. SQ SEQUENCE 259 AA; 28348 MW; 4BA41564316749DC CRC64; GGGADLGAGP GSHTFQRMYG CEVGSDGRLL RGYTQWAYDG ADYIALAEDL SSWVAADTAA LITQRKWVEA GVAERDRAYL EGTCVEWLRR HLENGKEQLQ RTDPPETRVT RHPFSKEEVT LRCWALGFYP AEISVTWQRD GQDLTQDMEL VETRPAGDGT FQTWAAVAVP SGEEQHYTCR VQHEGLPEPR TLTWERPLHP TMSRGVEVIA VTAALLGVVL IAVVAVGMWR RKRAGGKGAS YGPAASSDRA QGSDSSVMA // ID G5E5F5_BOVIN Unreviewed; 209 AA. AC G5E5F5; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 12-SEP-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000016352}; GN Name=LOC101903261 {ECO:0000313|Ensembl:ENSBTAP00000016352}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000016352, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000016352, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000016352, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000016352} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000016352}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02027081; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G5E5F5; -. DR STRING; 9913.ENSBTAP00000016352; -. DR PaxDb; G5E5F5; -. DR Ensembl; ENSBTAT00000016352; ENSBTAP00000016352; ENSBTAG00000024751. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G5E5F5; -. DR OMA; CKMWLEE; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Reactome; R-BTA-163125; Post-translational modification: synthesis of GPI-anchored proteins. DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000009136; Chromosome 9. DR Bgee; ENSBTAG00000024751; Expressed in 8 organ(s), highest expression level in heart. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}. FT DOMAIN 31 202 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 209 AA; 23578 MW; 587EE9F29F6A0CAC CRC64; VVLGARGAFL LYQPSPAALL GSHISGGRRD THSLFYNFTV DRHPSPGEPW CVVQGQIDGN FFLSYDCGGT KIQSTSPLGE EVKTTNTWET QTEPLRNIGD FLKGQLPDII PEKHTARVES SPLTLQARMT CQCEEDGHIS GSWQFGFNGE MCLRFDSENG HWTEVHSGGR RMKEKWEKDR AVTDFFKNVS MGDCQAWLQD FIVCWEKML // ID G5E5L3_BOVIN Unreviewed; 231 AA. AC G5E5L3; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 12-SEP-2018, entry version 37. DE SubName: Full=UL16-binding protein 27 precursor {ECO:0000313|Ensembl:ENSBTAP00000025021}; GN Name=ULBP27 {ECO:0000313|Ensembl:ENSBTAP00000025021}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000025021, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000025021, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000025021, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000025021} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000025021}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02027088; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9913.ENSBTAP00000025021; -. DR PaxDb; G5E5L3; -. DR Ensembl; ENSBTAT00000025021; ENSBTAP00000025021; ENSBTAG00000036061. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G5E5L3; -. DR OMA; QIAKRPL; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Reactome; R-BTA-163125; Post-translational modification: synthesis of GPI-anchored proteins. DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000009136; Chromosome 9. DR Bgee; ENSBTAG00000036061; Expressed in 8 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 209 230 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 15 183 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 231 AA; 26392 MW; 355BE08ED2E84BCD CRC64; GSPCAMNQHC TLCNAHSLSY NVTIDPRPRD GQPWCEVQGE VDQKVFLSYD CGRAKIMYMS PLGEEVKSMN SWETQTDTLR DIGDLLKEQM PDVTPEKHID EGPLTLQARM TCWREDNGHT SASWEFGFNG QLCLLFDSEN GYWTMVHSKG RRMKEKWEND RAVMDFFKKV SMGDCQRWYH TSLVRWEKML KTAASPTEAP LRVNSTATAT KHVTCILPVL LSSFIIIVFL G // ID G5E5X5_BOVIN Unreviewed; 276 AA. AC G5E5X5; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 12-SEP-2018, entry version 31. DE SubName: Full=UL16 binding protein 3 precursor {ECO:0000313|Ensembl:ENSBTAP00000037395}; GN Name=ULBP3 {ECO:0000313|Ensembl:ENSBTAP00000037395}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000037395, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000037395, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000037395, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000037395} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000037395}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02044837; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9913.ENSBTAP00000037395; -. DR PaxDb; G5E5X5; -. DR Ensembl; ENSBTAT00000037567; ENSBTAP00000037395; ENSBTAG00000026437. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; G5E5X5; -. DR OMA; ISASWEF; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Reactome; R-BTA-163125; Post-translational modification: synthesis of GPI-anchored proteins. DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000009136; Chromosome 17. DR Bgee; ENSBTAG00000026437; Expressed in 8 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 203 225 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 3 174 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 276 AA; 31584 MW; 50EDD7F07FA9B4D9 CRC64; TDAHSLSYNI TIDPRPRDGQ PWCEVQGEVD QKVFLSYDCG RAKIKYMSPL GEEVKSMNAW EAQTDTLRDI GDLLKEQMTD VTPEKHLDKV GSGPLTLQAR MSCWQEDNGL ISASWEFGFN GQLCLLFDSE SGYWTMVHSK GRWMKEKWEN DRAVTEFFKK VSRADCQRWY QDFLLHWEKM LKTTASPTTG PSTMQRMAPD SSYSTWIATG VLAGFVITII IIACIHYKKR RLCSQEARDR CSVGLRTQSL LGSFCCPAVH LRAKRSDLRN PKSVYQ // ID G7NXI2_MACFA Unreviewed; 326 AA. AC G7NXI2; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 25-OCT-2017, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHH50747.1}; GN ORFNames=EGM_01621 {ECO:0000313|EMBL:EHH50747.1}; OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130}; RN [1] {ECO:0000313|EMBL:EHH50747.1, ECO:0000313|Proteomes:UP000009130} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH50747.1}; RX PubMed=22002653; DOI=10.1038/nbt.1992; RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., RA Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., RA Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., RA Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., RA Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., RA Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J., RA Wang X., Wang J.; RT "Genome sequencing and comparison of two nonhuman primate animal RT models, the cynomolgus and Chinese rhesus macaques."; RL Nat. Biotechnol. 29:1019-1023(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CM001276; EHH50747.1; -; Genomic_DNA. DR Proteomes; UP000009130; Chromosome 1. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000009130}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009130}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 285 308 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 188 284 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 326 AA; 37840 MW; 202F2BADC1EF4BD8 CRC64; MVKHSDSRTH SLRYFRLGIS DPGHGVPEFI SVGYVDSQPI TTYDSVTWQK EPRAPWMAEN LAPDHWERYT QLLRGWQQTF KVELKRLQRH YNHSGSHTYQ RMIGCELLED GSTTGFLQYA YDGQDFLIFN KDSLSWLAVD NVAHTVKRAW EANQHELRYQ KNWLEKECIA WLKRFLEYGN DTLQRTEPPL VRVNRKETFP GVTTLFCKAY SFYPPEIYMT WMKNGEEIVQ EMDYGDILPS GDGTYQTWAS VELDPKSSNL YSCHVEHCGV HMVLQVPQES ETIPLVMKAV SGSIILVIVL AGVGVLVWRR RPREQNGAMY LPTPDR // ID G7P0C0_MACFA Unreviewed; 298 AA. AC G7P0C0; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 25-OCT-2017, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHH52032.1}; GN ORFNames=EGM_12396 {ECO:0000313|EMBL:EHH52032.1}; OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130}; RN [1] {ECO:0000313|EMBL:EHH52032.1, ECO:0000313|Proteomes:UP000009130} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH52032.1}; RX PubMed=22002653; DOI=10.1038/nbt.1992; RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., RA Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., RA Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., RA Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., RA Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., RA Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J., RA Wang X., Wang J.; RT "Genome sequencing and comparison of two nonhuman primate animal RT models, the cynomolgus and Chinese rhesus macaques."; RL Nat. Biotechnol. 29:1019-1023(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CM001278; EHH52032.1; -; Genomic_DNA. DR Proteomes; UP000009130; Chromosome 3. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000009130}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000009130}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 298 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003501489. FT DOMAIN 207 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 298 AA; 34423 MW; E50734B85C8E8D05 CRC64; MVRMVPVLLS LLLFLGPAVP QETQDGRYSL TYIYTGLSKL VEDIPQFQAL GSLNDLQFFR YNSKDRKSQP VGLWRQVEGM EDWKQDSQLQ KAREDIFMET LNDIVEYYND SNGSHNLHGR FGCEIENNRS SGSFWKYYYD GKDYIEFNKE IPAWVPLVPE AQNTKQKWEA EPVYMQRAKA YLEEECPETL QKCLKYSKNI LDRQHPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT RDGKVQEPEL RGEVLHNENG TYQSWVVVAV PPQDTAPYSC HVQHSSLAQP LVVPGEAR // ID G7P2L8_MACFA Unreviewed; 348 AA. AC G7P2L8; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 25-OCT-2017, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHH52787.1}; GN ORFNames=EGM_13302 {ECO:0000313|EMBL:EHH52787.1}; OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130}; RN [1] {ECO:0000313|EMBL:EHH52787.1, ECO:0000313|Proteomes:UP000009130} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH52787.1}; RX PubMed=22002653; DOI=10.1038/nbt.1992; RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., RA Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., RA Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., RA Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., RA Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., RA Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J., RA Wang X., Wang J.; RT "Genome sequencing and comparison of two nonhuman primate animal RT models, the cynomolgus and Chinese rhesus macaques."; RL Nat. Biotechnol. 29:1019-1023(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CM001279; EHH52787.1; -; Genomic_DNA. DR Proteomes; UP000009130; Chromosome 4. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000009130}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009130}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 348 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003501618. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 348 AA; 40325 MW; 24EBF4A8EB7DF172 CRC64; MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGSSEQ DLGLSLFEAL GYVDDQLFVF YDHESRRVEP RTPWVSGRTS SQMWLQLSQS LKGWDHMFTV DFWTIMENHN HSKESHTLQV ILGCKMQEDN STEGFWKYGY DGQDHLEFCP DTLDWRAAEP RAWPTKLEWE RHKIRARQNR AYLERDCPVQ LQQLLELGRG VFDRPVPPLV KVTHHVTSSV TTLRCRALNY YPQNITMKWL KDRQPMDAKE VEPKDVLPNG DGTYQGWITL TVPPGEEQRY TCQVEHPGLD QPLLAFWEPS PSRTLVIGVI SGIAVFVIIL FIGILFIILR KRQTSRGVMG HYVLAERE // ID G7P4Z0_MACFA Unreviewed; 210 AA. AC G7P4Z0; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 25-OCT-2017, entry version 16. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHH53308.1}; DE Flags: Fragment; GN ORFNames=EGM_13923 {ECO:0000313|EMBL:EHH53308.1}; OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130}; RN [1] {ECO:0000313|EMBL:EHH53308.1, ECO:0000313|Proteomes:UP000009130} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH53308.1}; RX PubMed=22002653; DOI=10.1038/nbt.1992; RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., RA Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., RA Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., RA Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., RA Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., RA Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J., RA Wang X., Wang J.; RT "Genome sequencing and comparison of two nonhuman primate animal RT models, the cynomolgus and Chinese rhesus macaques."; RL Nat. Biotechnol. 29:1019-1023(2011). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CM001279; EHH53308.1; -; Genomic_DNA. DR ProteinModelPortal; G7P4Z0; -. DR Proteomes; UP000009130; Chromosome 4. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009130}; KW Reference proteome {ECO:0000313|Proteomes:UP000009130}. FT DOMAIN 15 172 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:EHH53308.1}. FT NON_TER 210 210 {ECO:0000313|EMBL:EHH53308.1}. SQ SEQUENCE 210 AA; 24030 MW; 7E2FD09AC1456519 CRC64; DAHSLWYNFN ITHGQQWCEV QGQADQKNFL SYDCGSDKVL SMGHLEEQLD VTDAWGKQLE MLKEVGRRLR MKLADNKLED FTPSGPLTLQ ARMSCECEVD GPIRGSWQFS FNGQKFLLFD SNNRKWTVVQ AGAKRMKEKW EDSELTMFFQ KVSMGDCKSW LRDFLMHRKK RLEPTAPPTV APGTAQTKAM ATSLSPWSLL IILCFTLPGI // ID G7P4Z1_MACFA Unreviewed; 214 AA. AC G7P4Z1; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 25-OCT-2017, entry version 15. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHH53309.1}; DE Flags: Fragment; GN ORFNames=EGM_13924 {ECO:0000313|EMBL:EHH53309.1}; OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130}; RN [1] {ECO:0000313|EMBL:EHH53309.1, ECO:0000313|Proteomes:UP000009130} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH53309.1}; RX PubMed=22002653; DOI=10.1038/nbt.1992; RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., RA Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., RA Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., RA Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., RA Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., RA Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J., RA Wang X., Wang J.; RT "Genome sequencing and comparison of two nonhuman primate animal RT models, the cynomolgus and Chinese rhesus macaques."; RL Nat. Biotechnol. 29:1019-1023(2011). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CM001279; EHH53309.1; -; Genomic_DNA. DR Proteomes; UP000009130; Chromosome 4. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009130}; KW Reference proteome {ECO:0000313|Proteomes:UP000009130}. FT DOMAIN 2 172 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:EHH53309.1}. FT NON_TER 214 214 {ECO:0000313|EMBL:EHH53309.1}. SQ SEQUENCE 214 AA; 24309 MW; FF50201586311884 CRC64; DPHSLCYDIT IIPKFRPGPQ WCAVQGQVDK KTFLHYDCGN KTVTPVSPLG KKFSVTKAWK AQNPVLREVV DMLTEQLLDI QLENYTPREP LTLQAQVSCE QKAEGHSSGS WQFGFDGQVF LLFDSENRMW TTVHPGARKM KEKWENDKDV TMSFHYISMG DCTRWLGDFL MDMDSTLEPS AGEPPSLAQG TTHPKAMATT LIPWRLLLII LLCF // ID G7P4Z2_MACFA Unreviewed; 213 AA. AC G7P4Z2; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 25-OCT-2017, entry version 16. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHH53310.1}; DE Flags: Fragment; GN ORFNames=EGM_13925 {ECO:0000313|EMBL:EHH53310.1}; OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130}; RN [1] {ECO:0000313|EMBL:EHH53310.1, ECO:0000313|Proteomes:UP000009130} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH53310.1}; RX PubMed=22002653; DOI=10.1038/nbt.1992; RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., RA Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., RA Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., RA Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., RA Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., RA Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J., RA Wang X., Wang J.; RT "Genome sequencing and comparison of two nonhuman primate animal RT models, the cynomolgus and Chinese rhesus macaques."; RL Nat. Biotechnol. 29:1019-1023(2011). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CM001279; EHH53310.1; -; Genomic_DNA. DR ProteinModelPortal; G7P4Z2; -. DR Proteomes; UP000009130; Chromosome 4. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009130}; KW Reference proteome {ECO:0000313|Proteomes:UP000009130}. FT DOMAIN 14 170 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:EHH53310.1}. FT NON_TER 213 213 {ECO:0000313|EMBL:EHH53310.1}. SQ SEQUENCE 213 AA; 24807 MW; 05704FD3CADC05F2 CRC64; HCLSYDFIIT PKFRPEPRWC EVQGLVDERP FLHYDCVNHK AKAFASLGKK VNVTKTWEEQ TETLRDVVDF LKGQLPDIQV ENLVPIEPLI LQARMSCEHE AHGHGRGSWQ FLFNGQTFLL FDSNNRKWAV LHPGAKKMKD KWEKNTEVTM FFHKISVGDC KMWLEEFLMY WEKMPDPTKP HSRALGTTQP KTMATTLSPW SFLIVILCFI LPG // ID G7PY78_MACFA Unreviewed; 365 AA. AC G7PY78; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 31-JAN-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHH59789.1}; GN ORFNames=EGM_09981 {ECO:0000313|EMBL:EHH59789.1}; OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130}; RN [1] {ECO:0000313|EMBL:EHH59789.1, ECO:0000313|Proteomes:UP000009130} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH59789.1}; RX PubMed=22002653; DOI=10.1038/nbt.1992; RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., RA Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., RA Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., RA Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., RA Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., RA Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J., RA Wang X., Wang J.; RT "Genome sequencing and comparison of two nonhuman primate animal RT models, the cynomolgus and Chinese rhesus macaques."; RL Nat. Biotechnol. 29:1019-1023(2011). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CM001294; EHH59789.1; -; Genomic_DNA. DR RefSeq; NP_001271480.1; NM_001284551.1. DR RefSeq; XP_015296443.1; XM_015440957.1. DR RefSeq; XP_015296444.1; XM_015440958.1. DR UniGene; Mfa.8387; -. DR ProteinModelPortal; G7PY78; -. DR SMR; G7PY78; -. DR GeneID; 102128913; -. DR KEGG; mcf:102128913; -. DR CTD; 2217; -. DR Proteomes; UP000009130; Chromosome 19. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019864; F:IgG binding; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009130}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009130}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003502878. FT TRANSMEM 298 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 39877 MW; 809EFF1BD432A5DB CRC64; MRVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLS YDSLRGQAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE AFKALGGKGP YTLQGLLGCE LSPDNTSVPT AKFALNGEEF MNFDLKQGTW GGDWPEALAI SQRWQQQDKA ANKELTFLLF SCPHRLREHL ERGRGNLEWK EPPSMRLKAR PGNPGFSVLT CSAFSFYPPE LQLRFLRNGM AAGTGQGDFG PNSDGSFHAS SSLTVKSGDE HHYCCIVQHA GLAQPLRVEL ETPAKSSVLV VGIVIGVLLL TAAAVGGALL WRRMRSGLPA PWISLRGDDT GSLLPTPGEA QDADSKDINV IPATA // ID G8F5N4_MACFA Unreviewed; 328 AA. AC G8F5N4; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 25-OCT-2017, entry version 18. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHH62598.1}; DE Flags: Fragment; GN ORFNames=EGM_21001 {ECO:0000313|EMBL:EHH62598.1}; OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130}; RN [1] {ECO:0000313|EMBL:EHH62598.1, ECO:0000313|Proteomes:UP000009130} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH62598.1}; RX PubMed=22002653; DOI=10.1038/nbt.1992; RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., RA Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., RA Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., RA Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., RA Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., RA Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J., RA Wang X., Wang J.; RT "Genome sequencing and comparison of two nonhuman primate animal RT models, the cynomolgus and Chinese rhesus macaques."; RL Nat. Biotechnol. 29:1019-1023(2011). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH331984; EHH62598.1; -; Genomic_DNA. DR Proteomes; UP000009130; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009130}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009130}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 293 316 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 188 277 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:EHH62598.1}. FT NON_TER 328 328 {ECO:0000313|EMBL:EHH62598.1}. SQ SEQUENCE 328 AA; 36742 MW; FD9D3AFAEA4BC1D5 CRC64; SSSPELHTLR YNVTVLSRDG SVQSEFLAEG HLDGQLFLLY DRQKCRARPQ GQWSEDVLGA KTWDTETGDL TENGKDLRMT LAHIKGQKGG LHSLQEIKVC EIHEDNSTGG LRHFYYDGEL FLSQNLETQE WTELQSSRAQ TLALNIRNFW KEDTMKTKTH YRTVQADCLK KLQRYLESGV AVRRTAPPMV NVTHSEASEG NITVTCRASG FYPRNIALTW RQDGVSLNHN AQQWGGILPD QNGTYQTWVA TKIRQGEEQK FACYMEHSGN HSTHPVPSGK VLVFQSQWLD IPYVLAVAAA VAAAAAAIFV IILYVLCCKK KTSAAEGP // ID G8F5V6_MACFA Unreviewed; 307 AA. AC G8F5V6; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 25-OCT-2017, entry version 16. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHH62670.1}; DE Flags: Fragment; GN ORFNames=EGM_21084 {ECO:0000313|EMBL:EHH62670.1}; OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130}; RN [1] {ECO:0000313|EMBL:EHH62670.1, ECO:0000313|Proteomes:UP000009130} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH62670.1}; RX PubMed=22002653; DOI=10.1038/nbt.1992; RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., RA Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., RA Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., RA Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., RA Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., RA Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J., RA Wang X., Wang J.; RT "Genome sequencing and comparison of two nonhuman primate animal RT models, the cynomolgus and Chinese rhesus macaques."; RL Nat. Biotechnol. 29:1019-1023(2011). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH332188; EHH62670.1; -; Genomic_DNA. DR ProteinModelPortal; G8F5V6; -. DR Proteomes; UP000009130; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009130}; KW Reference proteome {ECO:0000313|Proteomes:UP000009130}. FT DOMAIN 3 173 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:EHH62670.1}. FT NON_TER 307 307 {ECO:0000313|EMBL:EHH62670.1}. SQ SEQUENCE 307 AA; 33930 MW; C04FAA1F9D56D812 CRC64; TDPHSLCYDI TIIPKFRPGP RWCAVQGQVD KKTFLHYDCG NKTVTPVGHL GKKLNVTKAW KAQNPVLREV VDMLTEQLLD IELENYTPRE PLTLQAQVSC EQKAEGHSSG SWQFGFDGQV FLLFDSENRM WTTVHPGARK MKEKWENDKD VTMSFHYISM GDCTRWPKDF LTGTDSTLEP SAGAPPTMSS GAAQLRATAT TLILCCLLLM CLLMCSRHSP THSHGHHPQS LEPPPPPPLL HPPWLLSRVL WSDSYQIGKG PLSGGHMTHV TLPIIGDDSH ALPCPLALYT INNGTARHSG PLPASAS // ID G8F690_MACFA Unreviewed; 343 AA. AC G8F690; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 20-DEC-2017, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHH62804.1}; DE Flags: Fragment; GN ORFNames=EGM_19426 {ECO:0000313|EMBL:EHH62804.1}; OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130}; RN [1] {ECO:0000313|EMBL:EHH62804.1, ECO:0000313|Proteomes:UP000009130} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH62804.1}; RX PubMed=22002653; DOI=10.1038/nbt.1992; RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., RA Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., RA Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., RA Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., RA Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., RA Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J., RA Wang X., Wang J.; RT "Genome sequencing and comparison of two nonhuman primate animal RT models, the cynomolgus and Chinese rhesus macaques."; RL Nat. Biotechnol. 29:1019-1023(2011). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JH334156; EHH62804.1; -; Genomic_DNA. DR Proteomes; UP000009130; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000009130}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009130}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 343 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003509727. FT TRANSMEM 310 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 89 109 {ECO:0000256|SAM:Coils}. FT NON_TER 343 343 {ECO:0000313|EMBL:EHH62804.1}. SQ SEQUENCE 343 AA; 38478 MW; FC6FB6079E679543 CRC64; MGLGRVLLFL GRVLLFLASI FSFTRPGAAA ELHSLRYNVT VLSRDGSVQS EFLAEGHLDG QLFVRYDRET RRARPQGQWA EAVLGDQETE DLTENAQDLR RTLTHIEGQK GGLHSLQEIK VCEIHEDNST GGLRHFYYDG ELFLSLNLET QKWTVAQSSR AQTLAMNFWK EDTMKTKTHY RTVQADCLKK LQRYLESGVA VRRTVPPMVN VTHGEASEGN ITVTCRASGF YPGNITLTWR QDGVSLSHDA QQWGDVLPDW NGTYQTWVAT KIRQGEEQKF ACYMEHSGNH STHPVPSGKP PVLQSERLNL LYVLVAVAVA ITAFIIICVH CCKKKKTSAA EGP // ID H0UVX3_CAVPO Unreviewed; 363 AA. AC H0UVX3; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 12-SEP-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000001179}; GN Name=LOC100713873 {ECO:0000313|Ensembl:ENSCPOP00000001179}; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Caviidae; Cavia. OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000001179}; RN [1] {ECO:0000313|Ensembl:ENSCPOP00000001179} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000001179}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSCPOP00000001179} RP IDENTIFICATION. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000001179}; RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAKN02056636; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAKN02056637; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_013004275.1; XM_013148821.1. DR ProteinModelPortal; H0UVX3; -. DR STRING; 10141.ENSCPOP00000001179; -. DR Ensembl; ENSCPOT00000001316; ENSCPOP00000001179; ENSCPOG00000007659. DR GeneID; 100713873; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H0UVX3; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005447; Unassembled WGS sequence. DR Bgee; ENSCPOG00000007659; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005447}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005447}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 363 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5011522627. FT TRANSMEM 307 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 363 AA; 40788 MW; E5B90C3B81502193 CRC64; MAEVAPRTLL LLLSGVLVLT ETRAGSHSLR YFHTAVSRPG RGDSRFFSVG YVDGTQFVRF DSDAENPREE PRAPWMEREG QEYWDGQTQI AKDSAQTYRV DLRTLRGYYN QSEDASHTLQ RMYGCEVGPD GRFLSEYMQD AYDVKDYIAL AEDLSTWVAA DTAAQITQRK WVQAGEAERY RAYLQGKCVE WLLRYLEHGK EKLQRADPPE AHVTRHPTSK EQVTLRCWAL GFYPEEISVT WQRDGQELTQ EMELVETRPD GDGNFQKWVA VVVPSGEEQN YTCHVQHEGL SEPLALRWES SQPSIPILGV VAAVIVLVAV LTGVVGFVIW RRSRAGAKGG NYTQAARGDS AQGSDSSLMA GKA // ID H0UYB2_CAVPO Unreviewed; 363 AA. AC H0UYB2; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 12-SEP-2018, entry version 48. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000002116}; GN Name=LOC100713317 {ECO:0000313|Ensembl:ENSCPOP00000002116}; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Caviidae; Cavia. OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000002116}; RN [1] {ECO:0000313|Ensembl:ENSCPOP00000002116} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000002116}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSCPOP00000002116} RP IDENTIFICATION. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000002116}; RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAKN02056634; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 10141.ENSCPOP00000002116; -. DR Ensembl; ENSCPOT00000002362; ENSCPOP00000002116; ENSCPOG00000002330. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H0UYB2; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005447; Unassembled WGS sequence. DR Bgee; ENSCPOG00000002330; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005447}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005447}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 363 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013356855. FT TRANSMEM 308 330 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 363 AA; 41029 MW; FF004558EF1E47F3 CRC64; MTVMAPRTLL LLLSGALVLT ETRAGSHSLR YFHTAVSRPG RGDSRFISVG YVDDTQFVRF DSDAESPRME PRAPWMERED QEYWDRETRN AKDAAQSYKR SLRNLRGYYN QSADVSHTVQ RMYGCVVGLD GRFLGGYWQY GYDGDDYIVL AEDLSSWVAA DTAAQITQRK WVQAGVAEQE TAYLEGTCVE WLLRYLEHGK ETLQRADPPE THVTRHHISK EQVTLRCWAL GFYPKEISLT WQRDGQELTQ EMELVETRPD GNGTFQKWAA VIVPSGEEQN YMCRVRHEGL PEPRTLTWES PPQPSIPILG VVAAVILLVA VLTGVAFVVW RRKRAGVKGG NYTQAARDDS DQGSDSSVMA GKV // ID H0UZ47_CAVPO Unreviewed; 363 AA. AC H0UZ47; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 12-SEP-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000002441}; GN Name=LOC100713317 {ECO:0000313|Ensembl:ENSCPOP00000002441}; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Caviidae; Cavia. OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000002441}; RN [1] {ECO:0000313|Ensembl:ENSCPOP00000002441} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000002441}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSCPOP00000002441} RP IDENTIFICATION. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000002441}; RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAKN02056634; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_013004286.1; XM_013148832.1. DR ProteinModelPortal; H0UZ47; -. DR STRING; 10141.ENSCPOP00000002441; -. DR Ensembl; ENSCPOT00000002723; ENSCPOP00000002441; ENSCPOG00000002330. DR GeneID; 100713317; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H0UZ47; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005447; Unassembled WGS sequence. DR Bgee; ENSCPOG00000002689; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005447}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005447}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 363 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5011751944. FT TRANSMEM 306 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 363 AA; 40953 MW; E88E33968961174E CRC64; MTVMAPRTLL LLLSGALVLT ETRAGSHSLR YFHTAVSRPG RGDSRFISVG YVDDTQFVRF DSDAESPRME PRAPWMERED QEYWDRETRN AKDAAQSYKR SLRNLRGYYN QSADVSHTVQ RMYGCVVGLD GRFLGGYWQY GYDGDDYIVL AEDLSSWVAA DTAAQITQRK WVQAGVAEQE TAYLEGTCVE WLLRYLEHGK ETLQRADPPE AHVTHHPNSK DQVTLRCWAL GFYPKDISLT WQRDGQELTQ EMELVETRPD GDGNFQKWVA VVVPSGEEQN YMCRVRHEGL PEPLTLRWES PPQPSIPILG VVAAVILLVA VLTGVAFVVW RRKRAGVKGG NYTQAARDDS DQGSDSSVMA GKV // ID H0VAL4_CAVPO Unreviewed; 453 AA. AC H0VAL4; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 12-SEP-2018, entry version 49. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000006900}; GN Name=LOC100723960 {ECO:0000313|Ensembl:ENSCPOP00000006900}; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Caviidae; Cavia. OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000006900}; RN [1] {ECO:0000313|Ensembl:ENSCPOP00000006900} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000006900}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSCPOP00000006900} RP IDENTIFICATION. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000006900}; RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAKN02057238; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0VAL4; -. DR STRING; 10141.ENSCPOP00000006900; -. DR Ensembl; ENSCPOT00000007732; ENSCPOP00000006900; ENSCPOG00000001300. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H0VAL4; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005447; Unassembled WGS sequence. DR Bgee; ENSCPOG00000001300; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005447}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005447}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 30 {ECO:0000256|SAM:SignalP}. FT CHAIN 31 453 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012361721. FT TRANSMEM 319 343 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 453 AA; 50888 MW; B3DF08EA3692D427 CRC64; MLVPGLGATA SQTVLLLLPG ILFCTETCAG SHSLRYFHTA VSRPERGDSR FISVGYVDDT QFVRFDSDAE SPRMEPQAPW MDRVDQEYWD RETQGAKRDA DDYRVDLRTL RSYYNQSAEG SHTLQKMYGC EVGPEGSFLR GYKQWGYDGE DYIALTEDLS SWVAADTAAQ ITQREWVKAR KAEHHRAYLE GECMDWLLRH LEHGKETLQH AEPPKAHVTR HPVSKDQVTL RCWALGFYPK DISLTWQRDG QELTQELELV ETRPEGNGTF QKWVAVMVPS GEEQNYMCHV EHEGLPEPRT LRWAPLSQTP PPNSKSPSIP ILGVVAAVIL LVAVLTGIAF VMWKAGRGGV RGNYTQAARG DSAQGSDSSL MVGKGETPGG LKWERWAEAE GTQQGPCLTV NPVCEQRAPL LVFIRTWVLC PVFVFTLESW CSCVTRLCFL LLCVPRSIPC LHV // ID H0VNT3_CAVPO Unreviewed; 283 AA. AC H0VNT3; H0VLT7; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 20-JUN-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000012127}; GN Name=LOC106026888 {ECO:0000313|Ensembl:ENSCPOP00000012127}; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Caviidae; Cavia. OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012127}; RN [1] {ECO:0000313|Ensembl:ENSCPOP00000012127, ECO:0000313|Proteomes:UP000005447} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012127, RC ECO:0000313|Proteomes:UP000005447}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSCPOP00000012127} RP IDENTIFICATION. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012127}; RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSCPOP00000021305} RP IDENTIFICATION. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000021305}; RG Ensembl; RL Submitted (OCT-2017) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAKN02044025; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0VNT3; -. DR STRING; 10141.ENSCPOP00000011340; -. DR STRING; 10141.ENSCPOP00000012127; -. DR Ensembl; ENSCPOT00000012726; ENSCPOP00000011340; ENSCPOG00000012605. DR Ensembl; ENSCPOT00000013602; ENSCPOP00000012127; ENSCPOG00000012605. DR Ensembl; ENSCPOT00000044499; ENSCPOP00000021305; ENSCPOG00000012605. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; H0VNT3; -. DR OrthoDB; EOG091G0I62; -. DR OrthoDB; EOG091G0NI5; -. DR TreeFam; TF341724; -. DR Proteomes; UP000005447; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005447}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005447}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 43 {ECO:0000256|SAM:SignalP}. FT CHAIN 44 283 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015092181. FT TRANSMEM 243 263 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 51 227 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 283 AA; 31746 MW; 3757A0A57F3ACA89 CRC64; MVFEALAGAA WKLARVPTGR GNPAAILCFF LAVLVLLLQL AEPLPVASAG THSLFYEFIT TPKSLPGQQQ CKIQGQLDQK IFLSYDCVGA KANTSMGVLG GKLNSTKSWN DQLKTLEDLA TEFRKLLWDI KLEDFASTDP HFFMARMSCL QKADGNILGF WDFGCNGKVF LHFHSNNKTW EDLLSGFSSM KEKLKNDMEL REILYWTSRV DCRSWFKEFL EHSEENLQTT APPTTPAGSE STLMTALLSG LVLVLIISCF LVYKAIKLRY MKKCSRLRFS SAA // ID H0VNX2_CAVPO Unreviewed; 337 AA. AC H0VNX2; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 12-SEP-2018, entry version 46. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSCPOP00000012171}; GN Name=MR1 {ECO:0000313|Ensembl:ENSCPOP00000012171}; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Caviidae; Cavia. OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012171}; RN [1] {ECO:0000313|Ensembl:ENSCPOP00000012171} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012171}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSCPOP00000012171} RP IDENTIFICATION. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012171}; RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAKN02017643; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_013013540.1; XM_013158086.1. DR ProteinModelPortal; H0VNX2; -. DR STRING; 10141.ENSCPOP00000012171; -. DR Ensembl; ENSCPOT00000013653; ENSCPOP00000012171; ENSCPOG00000013519. DR GeneID; 100713400; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H0VNX2; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005447; Unassembled WGS sequence. DR Bgee; ENSCPOG00000013519; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005447}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005447}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 337 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5011460120. FT TRANSMEM 296 319 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 278 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 337 AA; 38909 MW; FC64326CFD7DC6B3 CRC64; MVLLLSLITV LTVKFTHART HSLVYFRLGL SDPGPGVPEF ISVGYVDSHP ITTYDSVTRR KEPRAPWMAE NLAPDHWERY TQLLRGWQQT FKKELRHLQR HYNHSGFHTY QRMIGCELLE DGSTTGFLQY AYDGQDFIIF NKDTLSWVAV DNVAHITKRA WEANQHELQY QKNWLEKECI AWLKRFLEYG KDTLQRTEPP VIRTYRKETF PGITALFCRA HGFYPPEISM MWLKNGEGIT QEADYGDILP SGDGTYQTWV SVELDPQSSD MYSCRVEHCG LQMVVQGPQE SKVRLLVIQA VPAALGLSIV LFGIGIWAWK RRPQEKNGVI YHPASDQ // ID H0VXB0_CAVPO Unreviewed; 269 AA. AC H0VXB0; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 12-SEP-2018, entry version 45. DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSCPOP00000015340}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSCPOP00000015340}; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Caviidae; Cavia. OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000015340}; RN [1] {ECO:0000313|Ensembl:ENSCPOP00000015340} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000015340}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSCPOP00000015340} RP IDENTIFICATION. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000015340}; RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAKN02046407; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 10141.ENSCPOP00000015340; -. DR Ensembl; ENSCPOT00000026760; ENSCPOP00000015340; ENSCPOG00000025125. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H0VXB0; -. DR OrthoDB; EOG091G0KJB; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005447; Unassembled WGS sequence. DR Bgee; ENSCPOG00000025125; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005447}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005447}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 269 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013152882. FT TRANSMEM 209 230 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 111 198 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 269 AA; 28967 MW; 8E1B8F09A565EBF3 CRC64; MGEPGPPRPW ALGLLLLLLP QTWGAENHLS LLYHLTAVSS PATGSPAFWV SGWLGPQQYL SYSSLRREAE PCGAWVWETQ VSWYWEMETT DLKNKESLFL EALKALGGKE PPSMRLKARP GDAGFSVLTC SAFSFYPPEL QLRFLHNGLA AGTGEGGFGP NGDGSFHAWS SLTVQRGDEH NYRCLVQHAG LPQPLSVELE SPAGSSVPIV GIVLGFLLLI ATAAGGVLLW RRMRSGLPAP WISLRGDDVG SLLPGPLQEP DSPDARGTA // ID H0W4S6_CAVPO Unreviewed; 264 AA. AC H0W4S6; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 20-JUN-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000017977}; GN Name=LOC106026888 {ECO:0000313|Ensembl:ENSCPOP00000017977}; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Caviidae; Cavia. OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000017977}; RN [1] {ECO:0000313|Ensembl:ENSCPOP00000017977} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000017977}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSCPOP00000017977} RP IDENTIFICATION. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000017977}; RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAKN02044025; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_013004279.1; XM_013148825.1. DR ProteinModelPortal; H0W4S6; -. DR STRING; 10141.ENSCPOP00000017977; -. DR Ensembl; ENSCPOT00000023866; ENSCPOP00000017977; ENSCPOG00000012605. DR GeneID; 101787270; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; H0W4S6; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000005447; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005447}; KW Reference proteome {ECO:0000313|Proteomes:UP000005447}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 43 {ECO:0000256|SAM:SignalP}. FT CHAIN 44 264 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5011437192. FT DOMAIN 51 224 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 264 AA; 29319 MW; 7AE401B565816F11 CRC64; MVFEALAGAA WKLARVPTGR GNPAAILCFF LAVLVLLLQL AEPLPVASAG THSLFYEFII NPKPLPGQQE CKIQGQLDQK IFLSYDYVGA KAISMGVLGG KLNSTKSWNY QLETLQDVAT EFKQQVWDIK LEDCASTDPH FFMARMTCLQ KADGNIVGFW DFGCNGKVFL HFHSNNKTWE DLLTGSRCMK KLKNVELSEL LYRTSLYDCG SWLKEYLEPS EENLQTTAPP TTGAATPPTS KATRLSHRAL LLILPCSLIL LNVV // ID H0WPA1_OTOGA Unreviewed; 362 AA. AC H0WPA1; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000003699}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000003699, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000003699} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000003699} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03060173; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 30611.ENSOGAP00000003699; -. DR Ensembl; ENSOGAT00000004149; ENSOGAP00000003699; ENSOGAG00000004146. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H0WPA1; -. DR OMA; QPRFIAV; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003544788. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 304 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40840 MW; 090AB849BDC82B67 CRC64; LLLLLSVALV LTQTWAGSHS LRYFSTAVSR PGRGAPRYIA VGYVDDTQFV RFDSDTENLR MEPRAPWAER EGPVYWEEET QRIKDLAQIE RVCPDILRGY YNQSEGAGSH TYQRMYGCDV GPDRRLLRGY YQDAYDGADY RALNQDLRSW TAADKTAQIT QLKWEAEGAA ERYAEHWRVY LEGRCVESLR RHLEYGKDTL QRADPPKTRV THHPTSDSEA TLRCWALGFY PAEITLTWQR DGEDQTQDTE LIETRPSGDN RTFQKWAAVV VPSGEEQRYT CHVQHEGLLE PLTLRWESSQ PSISMVGIIA GLVLLGTVLT GAVVAAVMWR RKSSGGKGGS YTQAESSDSA QGSNVSLTTY KG // ID H0WUV2_OTOGA Unreviewed; 363 AA. AC H0WUV2; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 20-JUN-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000006055}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006055, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000006055} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000006055} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03060206; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 30611.ENSOGAP00000006055; -. DR Ensembl; ENSOGAT00000006771; ENSOGAP00000006055; ENSOGAG00000006768. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H0WUV2; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 363 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003544013. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 363 AA; 40383 MW; 6E83C204072BC897 CRC64; MGVTAPRTLL RLLSAALVLT ESWAGSHSMR YFHTAVSRPG RGEPRFISVG YVDDTQFVRF DSDADNRRME PRAPWVEREG PEYWDQQTRI AKDNAQFYRV GLEILRGYYN QSEDGSHTIQ VMSGCDVGPD GRLLRGYRQD AYDGADYIAL NEDLRSWTAA DTAAQITQRK WEAEGVAEGD RAYLEGTCVE WLRRYLENGK DTLQRADPPE ARVSHHSTSD PEATLRCWAQ GFYPAEITLT WQRDGEDQTQ DMELIETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLSLRWEP SSQPSILVVG IVAGLVLLLT VLIGAVVVMW MKKSSGGKGG SYTQAAISDS AQGSDVSLTA CKG // ID H0WVC6_OTOGA Unreviewed; 237 AA. AC H0WVC6; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 20-JUN-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000006256}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006256, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000006256} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000006256} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03075488; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0WVC6; -. DR STRING; 30611.ENSOGAP00000006256; -. DR Ensembl; ENSOGAT00000006991; ENSOGAP00000006256; ENSOGAG00000006990. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; H0WVC6; -. DR OMA; CKMWLEE; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 237 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003544026. FT DOMAIN 46 190 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 237 AA; 26787 MW; A7E2DD303A7629C0 CRC64; MALTEKTNFI SCILVVLLRY CLWAVGAKTH SLSYDFTITR LGCEVQGQVD EIAFLRYECG SKKVKPFGAL GKELNGTKTW KEQTETLKDL MDVLTQQLPD LQLGSYTQKD PLPLQATMSC QREANGHTTG SWQFGYKGQK FLLFDPENIK WTLLHPGGRQ MKEMWEHGRD MTMVFQKTSV GDCARWLEDF WMCCEKSLKA TALPTQATRI AQPKGTATTS IPWSLHVILP CSILLAI // ID H0WXH0_OTOGA Unreviewed; 348 AA. AC H0WXH0; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 12-SEP-2018, entry version 45. DE SubName: Full=Hemochromatosis {ECO:0000313|Ensembl:ENSOGAP00000007153}; GN Name=HFE {ECO:0000313|Ensembl:ENSOGAP00000007153}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000007153, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000007153} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000007153} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03059044; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_012659956.1; XM_012804502.1. DR ProteinModelPortal; H0WXH0; -. DR STRING; 30611.ENSOGAP00000007153; -. DR Ensembl; ENSOGAT00000007993; ENSOGAP00000007153; ENSOGAG00000007990. DR GeneID; 100966664; -. DR CTD; 3077; -. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H0WXH0; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl. DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:Ensembl. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl. DR GO; GO:0030881; F:beta-2-microglobulin binding; IEA:Ensembl. DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl. DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0071281; P:cellular response to iron ion; IEA:Ensembl. DR GO; GO:0042446; P:hormone biosynthetic process; IEA:Ensembl. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:Ensembl. DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IEA:Ensembl. DR GO; GO:1904283; P:negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:Ensembl. DR GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; IEA:Ensembl. DR GO; GO:1900121; P:negative regulation of receptor binding; IEA:Ensembl. DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; IEA:Ensembl. DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR GO; GO:1904434; P:positive regulation of ferrous iron binding; IEA:Ensembl. DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl. DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl. DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IEA:Ensembl. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; IEA:Ensembl. DR GO; GO:1900390; P:regulation of iron ion import; IEA:Ensembl. DR GO; GO:2000008; P:regulation of protein localization to cell surface; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 348 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003545146. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 348 AA; 39906 MW; 0C84166BE336CE9A CRC64; MGQRARPAFI LLVLLQTLVV QGRLLRSHSL HYLFMGVSER DFGPSLFEAL GYVDDQLFVS YDHESRRVEP RAPWVCTRTS SQLWLQLSQI LKGWDHMFIV DFWTIMDNYN HSKESHTLQV ILGCEMQEDN STRGFWKYGY DGQDHLEFCP EALNWRASDS GAQATKLEWE VHDIRAKQNR AYLERDCPEH LQQLLELGRG ALDQQVPPLV KVTHRMTSAV TILQCQALNF YPQNITMKWL RDKQPLDAKE VESKDVLPNG DGTYQSRVAL AVTPGEEQRY TCQVEHPGLD QPLTATWEPL PSDTLVIGVI SGIAVCVIIF FTGVLFRILR KRHSSREAMG DYVLAESE // ID H0WY75_OTOGA Unreviewed; 351 AA. AC H0WY75; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 20-JUN-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000007447}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000007447, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000007447} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000007447} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03161058; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0WY75; -. DR Ensembl; ENSOGAT00000008319; ENSOGAP00000007447; ENSOGAG00000008315. DR eggNOG; ENOG410IGE3; Eukaryota. DR eggNOG; ENOG41114P3; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H0WY75; -. DR OMA; RMFGCEI; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 302 324 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 351 AA; 39587 MW; 28B0F14D53A0C6CD CRC64; ATQGPPVQVL LGLCCETQSV SAGTHTLHYH YLALSEPGPG LPRFLAVGYV DDQPFIRYDS STGRAKPQAP WMAPEDAQYW ETETLKQRTW EKVQQVEVWS LMDHHNQSGA GAHSAQRMFG CKIHEDGSSS SFWQFGFDGQ DHLSLDLETL SWVSAEPMAV WTKHWWEMER CYAEYDKAYL EGPCLNSLRQ YLELGGQSLT RRDPPSVHVT RNMAAGGEVI LRCWALGFYP RDILLSWWLG DEELTLETEH VETRPSGDGT YQTWVAVWVP TGEEARYTCH VQHPSLNHTL TVAWEWPSHG KFIPMVISAV LATVMLAGVV MILTKKCLQG RWGRNEGVGP SWNSSPVEKN A // ID H0X2P4_OTOGA Unreviewed; 308 AA. AC H0X2P4; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000009341}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000009341, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000009341} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000009341} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03038111; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSOGAT00000010443; ENSOGAP00000009341; ENSOGAG00000010435. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 268 291 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 201 267 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 308 AA; 35170 MW; 20DE5C597A83C1F7 CRC64; TVLQLPSPLQ ALIRFSSCPG THSLRYFRLG VSDPGRGLPE LISVGYVDSY PITTYDSVAQ QKKPKAPWRA ENLVPSHWER YRQLLRGWQQ TTQVELKQLQ RRHNHSGHHT YWRMTGCEVL EDGSTGIAVD NVVHVTKRVR EANQHELQYQ KNWLEEECIT WLKRLLGYGK DVLPEQLEPP LVRVHRKETF PGITTLQALH GFYSPEISMI WMRNGEEMDS GDILPSGDGT YQTRVSVELD PQSTDVYSCY MEHCGLHIVL QESESIPLVM KIIFGSVVLA MVLTGIGLLA WRRPQGKLNI GYLSLSNH // ID H0X5D2_OTOGA Unreviewed; 339 AA. AC H0X5D2; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000010481}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000010481, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000010481} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000010481} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03060189; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0X5D2; -. DR STRING; 30611.ENSOGAP00000010481; -. DR Ensembl; ENSOGAT00000011714; ENSOGAP00000010481; ENSOGAG00000011712. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H0X5D2; -. DR OMA; FQRMIGC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 339 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003544766. FT TRANSMEM 305 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 339 AA; 38443 MW; 87A187D75D59AED9 CRC64; MGVTAPRTLL LLLSAALVLT ESWAGSHSMT YFYTAVSRPG RGEPRFIAVG YVDDTQFVRF DSDAGNPRME PRAPWVEREG PEYWEEQTRR AKETAQTFRV NLRTLRGYYN QSEDGSHSIQ TMYGCDVGPD GRLLRGYMQF AYDGADYIAL NEDLRSWTAA DPAAQNTQRK WEAAGEAEGH RAYLEGTCVE WLRRYLENGK DTLQRADPPE ARVTHHSTSD REATLRCWAQ GFYPAEITLT WQRDEEDQTQ DMELIETRPA GDGTFQKWAA MVVPSGEEQR YTCRVQHEGL PEPLSVRWEP SSQPIILMLG IVAGLVLLLT VLIGAVVVMW RRKISGREG // ID H0X835_OTOGA Unreviewed; 375 AA. AC H0X835; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000011611}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000011611, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000011611} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000011611} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03060148; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAQR03060149; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0X835; -. DR STRING; 30611.ENSOGAP00000011611; -. DR Ensembl; ENSOGAT00000012958; ENSOGAP00000011611; ENSOGAG00000012956. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H0X835; -. DR OMA; TECEIHE; -. DR OrthoDB; EOG091G0ANY; -. DR TreeFam; TF342166; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 375 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003544577. FT DOMAIN 26 197 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 375 AA; 40538 MW; 088FB13F5B6F70A0 CRC64; LPSGQTFLPL LASMLPCAPC RAASRSHSLR YNLTVVSQHG SVSSKFFAEG HLDGERFLLY GKKGRAEPQG PWAKASLGIE VWDTETKDMR ENGKDLRMTL AQIIGQKGLG AARHSLQEIT ECEIHEDNST SGFRHFYYDG ELFLSQNLKT QKQIVPPSSG AHTLAMNIRK VWDEDAMTRP DAVLADCVQK LQRYLDSRMG FSLEELGPRR AYRRPGISEG FRPGGNSGRT QPAPCVSCGG EQGLALGLTA SPLPSSVAPT VNVTHSQVLD GYMGHSRNQS THTVLSGRAG LGLGEQRRNA PRPRSHRLAI LCTALVIALA VVYKKRTSAA RGPDLVSLHV LDQGQVVTGA HEGTTQLGFQ VLLLAPGTTG HTEGT // ID H0XFS6_OTOGA Unreviewed; 358 AA. AC H0XFS6; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 20-JUN-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000014883}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000014883, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000014883} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000014883} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03060177; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0XFS6; -. DR STRING; 30611.ENSOGAP00000014883; -. DR Ensembl; ENSOGAT00000016632; ENSOGAP00000014883; ENSOGAG00000016630. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H0XFS6; -. DR OMA; MKNATQT; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 358 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003545162. FT TRANSMEM 304 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 358 AA; 39840 MW; 5FD9D3831DC56A23 CRC64; APGTLLLLLS AALVLTKTWA GSHSLRYFTT AVSRPGRGAP RYIEVGYVDD TLFVRFDGDA MNPRMEPRAP WVEREGPEYW VEETQKAKGN AQTDRVGLET LRGYYNQSED GSHTIQKTYG CYVGPDGSFL RGYMQFAYDG ADYITLNEDL SSWTAADTAA QITQRKWEAA GAAEHWRVYL EEECVVCLRR YLEKGKDTLQ RTDPPKTLVT HHPISDHEAT LRCWALGFYP AEITLTWQRD GEDQTQDMEL IETRPAGDRT FQKWAAVVVP SGEEQRYTCH VQHEGLREPL TLRWEPSSQP STPIVGIIAG LVLLGTVLTG AVVAAVMWRK KSSGGNGGSY TQAASNDRVQ ASNVSLTA // ID H0XGS6_OTOGA Unreviewed; 252 AA. AC H0XGS6; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000015293}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000015293, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000015293} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000015293} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03060171; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0XGS6; -. DR Ensembl; ENSOGAT00000017082; ENSOGAP00000015293; ENSOGAG00000017077. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H0XGS6; -. DR OMA; ECAWIGS; -. DR OrthoDB; EOG0907079Q; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 195 219 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 95 182 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 252 AA; 27591 MW; E6A3A8EDF01FC96C CRC64; GSHTILLMFG CDVGPDGRLL RGYLQSAYDG TDYIALNQDL RSWTAADTAA QITQRKWEAA DVAEQIRASL GAECVEPLGR HLEKGKDTQQ SADPPKTRVT HHPTSDHEAT LRCWALSFYP AEITLTWQRD GEDQIQDIEF IETRPSGDNR TFQKWVAVVV LPGEEQRYTC HVQHEGLQEP LTLRWEPSSQ PSMPMVSIVA GLLLLGALLT GAVVAAVMWR KKSSGGNGGR YTQAASSDTS LGSNGSLTAS LR // ID H0XIL7_OTOGA Unreviewed; 285 AA. AC H0XIL7; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000015957}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000015957, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000015957} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000015957} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03038111; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0XIL7; -. DR Ensembl; ENSOGAT00000030828; ENSOGAP00000015957; ENSOGAG00000010435. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 245 268 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 158 244 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 285 AA; 32364 MW; DAE6B520846DC0C4 CRC64; TVLQLPSPLQ ALIRFSSCPG THSLRYFRLG VSDPGRGLPE LISVGYVDSY PITTYDSVAQ QKKPKAPWRA ENLVPSHWER YRQLLRGWQQ TTQVELKQLQ RRHNHSGHHT YWRMTGCEVL EDGSTGIAVD NVVHVTKRVR EANQHELQYQ KNWLEEECIT WLKRLLGYGK DVLPEQSPEI SMIWMRNGEE MDSGDILPSG DGTYQTRVSV ELDPQSTDVY SCYMEHCGLH IVLQGKLSES ESIPLVMKII FGSVVLAMVL TGIGLLAWRR PQEPNGVSCL PAPDQ // ID H0XJ71_OTOGA Unreviewed; 355 AA. AC H0XJ71; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSOGAP00000016161}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSOGAP00000016161}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000016161, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000016161} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000016161} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03172716; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAQR03172717; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAQR03172718; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAQR03172719; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAQR03172720; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0XJ71; -. DR STRING; 30611.ENSOGAP00000016161; -. DR Ensembl; ENSOGAT00000025884; ENSOGAP00000016161; ENSOGAG00000033149. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H0XJ71; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019864; F:IgG binding; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 355 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003545752. FT TRANSMEM 300 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 355 AA; 39005 MW; ACE3644B5517491A CRC64; MGVPLPGRWA LALLLFLLPR TLRSESHLSL LYHLTAVSKP APGTPAFWVS GWLGPQQYLS YSNLRAQAEP CGAWVWENQV SWYWERETAD LRIKEKLFLE AFKALEGTGP YTLQGLLGCK LGPDNASVPT AKFALNGEEF MSFDLKKGTW NGDWPEAQAI SQQWMQQAEA ASKEMTFLLY SCPQRLQGHL ERGRGNLEWK EPPSMRLKAR PSSPGFSVLT CSAFSFYPPE LQLRFLRNGL AAGSGESDTG PNGDGSFHAW SSLTVKSGDE HHYRCLVQHA GLAQPLTVKL ESPVKSSMPV VGIIIGFLLL MAAAVGGVLL WRRMKNGLPA PWISLRGDDT GALLPAPGLS QDPDS // ID H0XJT6_OTOGA Unreviewed; 364 AA. AC H0XJT6; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000016376}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000016376, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000016376} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000016376} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03060202; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAQR03060203; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 30611.ENSOGAP00000016376; -. DR Ensembl; ENSOGAT00000032963; ENSOGAP00000016376; ENSOGAG00000031855. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H0XJT6; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003545108. FT TRANSMEM 307 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 40846 MW; 53537F2CE23CA32C CRC64; MGVTVPQTLL LLLSAALVLT EAWAGSHSMR YFSTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAENPREE PRAPWIEREG PEYWDEQTRR AKGAAQTFRV SLENLRRYYN QSEDAGSHTL QEMYGCDVGP DGRLLRGYQQ HAYDGADYIA LNEDLRSWTA ADPAAQITQR KWEAEGASEG DRAYLEEECV DWLRRYLENG KDTLQRADPP ETRVTHHPTS DHEATLRCWA QGFYPAEITL TWQRDGEDQT QDMELIETRP AGDGTFQKWA AVVVPSGEEQ RYTCHVQHEG LPEPLILRWG AASQPSMLMV GMVAGLVLLG TLLTGAVVVM WRKKSSGRKR GNYTQAAISD NAQGLDVSLT ACKS // ID H0XKS3_OTOGA Unreviewed; 186 AA. AC H0XKS3; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000016713}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000016713, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000016713} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000016713} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03038112; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0XKS3; -. DR STRING; 30611.ENSOGAP00000016713; -. DR Ensembl; ENSOGAT00000032087; ENSOGAP00000016713; ENSOGAG00000028147. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; EREACPR; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF342059; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}. FT DOMAIN 1 170 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 134 154 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 186 AA; 21812 MW; B7EC729A39031E4A CRC64; RYFRPGVSDP GHGLPELISV GYVDSYPITT YDSVAQQKKP KAPWRAENLV PSHWERYRQL LRGWQQTTQV ELKQLQRRHN HSGHHTYQRM TGCEVLEDGS TPGLLQYAYD RQDFLIFDKD SLSWMAVDNA AHVTKRAREA NQELQYQKNW LEEECVAWLK RFLENGKDVL QRTGKGEREA CPRTPR // ID H0XL25_OTOGA Unreviewed; 296 AA. AC H0XL25; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 20-JUN-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000016815}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000016815, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000016815} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000016815} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03148684; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAQR03148685; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0XL25; -. DR STRING; 30611.ENSOGAP00000016815; -. DR Ensembl; ENSOGAT00000031822; ENSOGAP00000016815; ENSOGAG00000031686. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H0XL25; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 296 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003546115. FT DOMAIN 203 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 296 AA; 33597 MW; 467072D3B7DE3411 CRC64; KVPVLLLLLL FLSPAVPQKT QAGTYTLTYL YTGLSRPSEG SPWLQAIVFL NDQAFFHYDS ESGKAEPLGP WKHIEGIKNW KQESLLQKVR ESIYLETLQD IMAFYNDSNG SHILQERLGC EVHNNISSGA FWKSAYDGKD FIEFNREIPT WVPLDPAAWN TKKKWEAEEV YVHRAKAYLE QECPDLLRGY LNYSRHILDQ QDPSSVSVTS RKSLGKNSIL KCQAYGFYPQ EISLHWTRAG EVQESESGGE VLPSGEGTYL STMELSVLPQ DRDAYSCLVE HSALAQPLSV SWDRRG // ID H0XP33_OTOGA Unreviewed; 368 AA. AC H0XP33; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000017874}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000017874, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000017874} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000017874} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03060218; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAQR03060219; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0XP33; -. DR STRING; 30611.ENSOGAP00000017874; -. DR Ensembl; ENSOGAT00000031636; ENSOGAP00000017874; ENSOGAG00000034304. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H0XP33; -. DR OMA; GYCQEAY; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 368 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003545226. FT DOMAIN 214 300 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 41254 MW; 53C8843605A5AF91 CRC64; MGVTAPRTLL RLLSAALVLT ESWAGSHSMR YFHTAVSRPG RGEPRYIEVG YVDDTQFVRF DSDAENPRME PRAPWIEREG PEYWERETRS AKGNAQTFRV NLRTALRYYN QSEDGSEGHP EAAGPLRPST RKGPAGTFTR FRFQFRTKSR XYIALNEDLR SWTAADTAAQ ITQRKWEAEG VAEGDRAYLE GTCVEWLRRY LENGKDTLQR ADPPEAHVTH HSTSDREATL RCWAQGFYPA EITLTWQRDG EDQTQDMELI ETRPAGDGTF QKWAAVVVPS GEEQKYTCHV QHEGLPEPLS LRWEPSSQPY ILMVGIVAGL ILLLTVLIGA VVVMRRRKSS GGKGGSYTQA AISDSAQGSD VSLTACKG // ID H0XPM0_OTOGA Unreviewed; 362 AA. AC H0XPM0; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 20-JUN-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000018061}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000018061, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000018061} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000018061} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03060182; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSOGAT00000029412; ENSOGAP00000018061; ENSOGAG00000026635. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H0XPM0; -. DR OMA; RMANEDW; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003545503. FT TRANSMEM 303 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40385 MW; 93E48D9E786DBF50 CRC64; MGFTGLRTLL QLLSALVLTE AWAGSHSLLY FTTSVFRPGR GEPRFIALGY VDDTQLVRVH SEAENPTVEP LAPWVELEYL EGLTQCANHR AQDDRLNLRF LHDYYNRSEN GSHTFQSVIG CDVGPDGRLL RGYQQHAYDG AEYISLNEDL RSWTAADTAA QITQRKWEAA GVAERRRAYL EGVCMEWLRR HLEKGKDTLQ RADPPKTHVT HHPTSDHEAT LRCWALDFYP AEITLTWQRD GEDQTQDMDL IETRPSGDDR TFQKWVAVVV PSGEEQRYTC HVQHEGLREP LTLRWESSSQ PSIPMGGIVA GLVLLGTLLT GAVVATVMRR KKSSGGKGGS YTQAASSDTA QGSDGSFIAA II // ID H0XPX2_OTOGA Unreviewed; 305 AA. AC H0XPX2; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000018163}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000018163, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000018163} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000018163} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03148685; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAQR03148686; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAQR03148687; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0XPX2; -. DR STRING; 30611.ENSOGAP00000018163; -. DR Ensembl; ENSOGAT00000025586; ENSOGAP00000018163; ENSOGAG00000034559. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H0XPX2; -. DR OMA; ENECPER; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 305 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003545256. FT DOMAIN 28 211 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 305 AA; 34807 MW; 34484A94CB737392 CRC64; TMATTVPVLL LLLLLLCPAV PEKTQPCNYT LTYLYIGQSM PSEDSPRFQA TGFLNDKEFL NYNSKDRKAK PQGPWKDIEE MENWEEESQL QRAREAIFMD TLEDIMAFYN DSNETFLPVE LKGSHILQER LGCEVHNNIS SGAFWKSAYD GKDFIEFNRE IPTWVPLDPA AWNTKKKWEA EEVYVHRAKA YLEQECPDLL RGYLNYSRHI LDQQAPILLV KRSWNVGGGV RGEGSHLFPA EITAFCKRSS EKQDCAMVQG HSMIPQGEGT YLSTMELSVL PQDRDAYSCL VEHSALAQPL SVAWD // ID H0XPX7_OTOGA Unreviewed; 312 AA. AC H0XPX7; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000018168}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000018168, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000018168} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000018168} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03038111; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0XPX7; -. DR STRING; 30611.ENSOGAP00000018168; -. DR Ensembl; ENSOGAT00000033825; ENSOGAP00000018168; ENSOGAG00000010435. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H0XPX7; -. DR OMA; GYVDSHP; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 272 295 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 179 271 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 312 AA; 35390 MW; D0AF443ADBEF6A92 CRC64; TVLQLPSPLQ ALIRFSSCPG THSLRYFRLG VSDPGRGLPE LISVGYVDSY PITTYDSVAQ QKKPKAPWRA ENLVPSHWER YRQLLRGWQQ TTQVELKQLQ RRHNHSGHHT YWRMTGCEVL EDGSTGIAVD NVVHVTKRVR EANQHELQYQ KNWLEEECIT WLKRLLGYGK DVLPEQLEPP LVRVHRKETF PGITTLQSSA GFYSPEISMI WMRNGEEMDS GDILPSGDGT YQTRVSVELD PQSTDVYSCY MEHCGLHIVL QGKLSESESI PLVMKIIFGS VVLAMVLTGI GLLAWRRPQE PNGVSCLPAP DQ // ID H0XW45_OTOGA Unreviewed; 365 AA. AC H0XW45; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000020338}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000020338, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000020338} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000020338} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03060062; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0XW45; -. DR STRING; 30611.ENSOGAP00000020338; -. DR Ensembl; ENSOGAT00000031553; ENSOGAP00000020338; ENSOGAG00000027556. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H0XW45; -. DR OMA; EDRTHNT; -. DR OrthoDB; EOG091G0BBK; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003545502. FT TRANSMEM 310 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 41636 MW; 1F33FECF05810262 CRC64; MKVTAPRTLL LLLSGVLVLT EVWAGSHSLR YFHTAVSRPG RGEPRFIEVG YVDNTQFVRF DSDAKNPRME PRAPWIEREG PEYWDEQTRR AKGHAQTFRV NLRTLRGYYN QSEDESHTLQ WMHGCDVGSD LRFLRGYEQF AYDGADYLSL NEDLRSWTAA NSAAQISKHK SDMTGEAEFQ RAYLEEECVE WLRRYLDSGK DALQRSDPPK IYITHHPVSD LKATLRCWAL GFYPAEITLT WHRDGEDQTQ DMELIETRPS GDNRTFQKWA AVVVPSGEEQ RYTCRVQHKG LQEPFTLRLE QPLQPRIHRL GITVVLISLG AVLTGIVFTT IMRAKSSGKE GGSYVPTLSV FSTQGSDVSL TASKD // ID H0XWQ5_OTOGA Unreviewed; 360 AA. AC H0XWQ5; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000020548}; GN Name=LOC100952503 {ECO:0000313|Ensembl:ENSOGAP00000020548}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000020548, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000020548} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000020548} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03060160; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0XWQ5; -. DR STRING; 30611.ENSOGAP00000020548; -. DR Ensembl; ENSOGAT00000026448; ENSOGAP00000020548; ENSOGAG00000033597. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H0XWQ5; -. DR OMA; GINDRTE; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 360 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003545800. FT TRANSMEM 306 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 360 AA; 40355 MW; DAFA5A09273DBC12 CRC64; AAPRILLLLL LGALVLTETC AGSHSLRYFS TAVSRPGRGA PQYIAVGYVD DTQFVRFDSD TENPRMEAWA PWAEREGPEY WDEETQRVKG HAQVNRVCVD ILRGRYNQSE GGSHTIQWMY GCDVGPDGRL LRGYWQEAYD GADHLTLNED LRSWTAADPV AQIAKRDLEA RRDAEYWRAY LEGRCVESLR RHLEYGKDTL QRADPPKTRV THHLTSDYEA TLRCWALGFY PAVITLTWQR DGEDQTQDME LVETRPSGDN RTFQKWAAVV VPSGEEHRYT CHVQHEGLGE PLTLRWEPSS QPSTPVVGII AGLVLLGTVL TGAVVATVMW RKKSSGGKGR SYTQATSSDR AQGSDVSLTA // ID H0XWT8_OTOGA Unreviewed; 363 AA. AC H0XWT8; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 20-JUN-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000020581}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000020581, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000020581} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000020581} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03060228; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 30611.ENSOGAP00000020581; -. DR Ensembl; ENSOGAT00000031963; ENSOGAP00000020581; ENSOGAG00000034852. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H0XWT8; -. DR OMA; VPGYYNQ; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 363 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003546464. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 363 AA; 40381 MW; 5C2C20DB840DFDCE CRC64; MGLTAPQTLL LPLLEVLVLT ETWAGSHSLK YFSTAVSRPG RGEPRYIAVG YVDDTQFVRF DSDGENPRVE PRAPWVAQEG PEYWERETRN AKGNAQTVRV NLRTLRGYYN QSEDGSHTIQ RTYGCDVGPD GRLLRGYYQY AYDGADYITL NEDLRSWTVA DPAARITQRK LEAAAEASYQ RAYLEGECVE SLRKYLENGK DVLQRADPPE TQVTHHSTSD HEATLRCWAQ GFYPAEITLT WQRDGEDQTQ DMELIETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLSLRWEP SSQPSILMVG IVAGLVLLLT VLIGAVVVMW RRKSSGGKGG SYTQAAISDS AQGSDVSLTA CKG // ID H0Y1D0_OTOGA Unreviewed; 233 AA. AC H0Y1D0; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000022173}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000022173, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000022173} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000022173} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03140336; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0Y1D0; -. DR STRING; 30611.ENSOGAP00000022173; -. DR Ensembl; ENSOGAT00000026138; ENSOGAP00000022173; ENSOGAG00000025001. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; H0Y1D0; -. DR OMA; QIAKRPL; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}. FT DOMAIN 1 169 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 233 AA; 27123 MW; 268136BCF154438E CRC64; HSLWYTFTIT PKSRHQPQWC KVQAQVDKMT FLHYDCGNKA TEPFGTLGQA VRGTNAWHEQ IETVHYMAEE LTKELLANLP EDFATSDPLI LQVKMSCQHK ANGHTTGSWD FGSTEKTFLT FDAENRTWKV HYAGAKQMKE KWEHDPHVTR FFYFTSMGDC KSWLTNFLMH WEKMPQFRGH PAFFPSHPLT LSHCTYFWSI HGGFLNLETL GILVFPALWP KGEWLVWSPL LPS // ID H0Y1E4_OTOGA Unreviewed; 352 AA. AC H0Y1E4; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000022187}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000022187, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000022187} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000022187} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03060181; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0Y1E4; -. DR STRING; 30611.ENSOGAP00000022187; -. DR Ensembl; ENSOGAT00000028371; ENSOGAP00000022187; ENSOGAG00000027064. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H0Y1E4; -. DR OMA; QRVYGCD; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 352 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003546297. FT TRANSMEM 298 322 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 201 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 352 AA; 39467 MW; DF88A77CDC7829AF CRC64; MGVTASRTLL LLSGALVVTE TLLGECGVGM FSTAVSQPGS REPRFITVGY VDDTQFVRFD SDAENPRMEP RAPWIEREGP EYWERETRIS KDKRETLRRY YNQSEEGSHT IQVMYGCDMG PDGRLLRGYY PDAYDGADYI ALNEDLRSWT AADSAAQITK HKWEAAGAAE GDRAYLECTC LEWLRRYLEN RKDTLQRADP PKIRVTHHPA SDREATLRCW ALGFYPAEIT LSWQRDGEDQ TQDMDLIETR PSGDGTFQKW TAVVVPSGEE QRYTCHVHHE GLREPHTVRW EPSSQPNILM VGIIAGLVLP GTVITGAVVV MWRKSSGGKG RTYIPAASSD SAQGSDESLT VI // ID H0Y1T1_OTOGA Unreviewed; 351 AA. AC H0Y1T1; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000022324}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000022324, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000022324} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000022324} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAQR03060155; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0Y1T1; -. DR Ensembl; ENSOGAT00000028582; ENSOGAP00000022324; ENSOGAG00000028468. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H0Y1T1; -. DR OMA; VTHHPVF; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 351 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003545978. FT TRANSMEM 298 320 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 351 AA; 40495 MW; F21C72306E8C62F8 CRC64; LLLLLPAALV LTQTWARSHS MRYFSTSVSR AGRAEAQYIE VGYVDDTQFV RFDSDAENPR MEPRAPWVKR EEPEYWDEET QRVKDLTQNF RMNLETLRRY YNQSEDAGSH TLQLMYGCYV GSDGRLLHGY WQYAYDGADY IALNQDLRSW TAADRAAQIT QRKLEAEGAA ERHRTYVEGT CVEWLLRYLK NGKDTLQRVD SPKTYVTHHP VSDLEATLRC WALGFYPAEI TLTWQRDGED QTQDMELIET RPSGDNRTFQ KWAAVVVPSG EEQRYTCHVQ HEGLPEPHTV RWEPSSQLII LVAIIAVLVV LGIVVAAVMW RKKSSGREGA SHSALSSHKW KRRELLSSCK Y // ID H0Y615_HUMAN Unreviewed; 223 AA. AC H0Y615; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 12-SEP-2018, entry version 41. DE SubName: Full=MHC class I polypeptide-related sequence A {ECO:0000313|Ensembl:ENSP00000402410}; DE Flags: Fragment; GN Name=MICA {ECO:0000313|Ensembl:ENSP00000402410}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000402410, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000402410, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000402410} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL645933; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0Y615; -. DR SMR; H0Y615; -. DR Ensembl; ENST00000421350; ENSP00000402410; ENSG00000204520. DR UCSC; uc063nam.1; human. DR EuPathDB; HostDB:ENSG00000204520.12; -. DR HGNC; HGNC:7090; MICA. DR OpenTargets; ENSG00000204520; -. DR GeneTree; ENSGT00740000114936; -. DR PhylomeDB; H0Y615; -. DR ChiTaRS; MICA; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204520; Expressed in 204 organ(s), highest expression level in ectocervix. DR ExpressionAtlas; H0Y615; baseline and differential. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|PeptideAtlas:H0Y615}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 98 187 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000402410}. SQ SEQUENCE 223 AA; 25242 MW; F30DBAC81E64A6E5 CRC64; FPFAPPGAAA EPHSLRYNLT VLSWDGSVQS GFLAEVHLDG QPFLRYDRQK CRAKPQGQWA EDVLGNKTWD RETRDLTGNG KDLRMTLAHI KDQKEVPPMV NVTRSEASEG NITVTCRASS FYPRNIILTW RQDGVSLSHD TQQWGDVLPD GNGTYQTWVA TRICRGEEQR FTCYMEHSGN HSTHPVPSGK VLVLQSHWQT FHVSAVAAGC CYFCYYYFLC PLL // ID H0ZVB6_TAEGU Unreviewed; 100 AA. AC H0ZVB6; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 23-MAY-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTGUP00000014563}; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; OC Estrildidae; Estrildinae; Taeniopygia. OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000014563, ECO:0000313|Proteomes:UP000007754}; RN [1] {ECO:0000313|Proteomes:UP000007754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20360741; DOI=10.1038/nature08819; RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., RA London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B., RA Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., RA Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M., RA Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P., RA Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T., RA Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A., RA Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E., RA Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D., RA Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H., RA Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J., RA Chinwalla A., Hou S., Mardis E.R., Wilson R.K.; RT "The genome of a songbird."; RL Nature 464:757-762(2010). RN [2] {ECO:0000313|Ensembl:ENSTGUP00000014563} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABQF01112620; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSTGUT00000014752; ENSTGUP00000014563; ENSTGUG00000014179. DR GeneTree; ENSGT00530000068158; -. DR InParanoid; H0ZVB6; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000007754; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007754}; KW Reference proteome {ECO:0000313|Proteomes:UP000007754}. FT DOMAIN 2 97 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 100 AA; 11605 MW; 3BAD67BCC1FAD1D8 CRC64; RGRYNQSRGG LHTVQGVSSC DLLSNSVHGF HQYGYEGWDF IFFQLGSRSF AVSNGAVWIS QRCWEHKGIM VEQMKHYLGH TCVERPPKYI RYGREALEHK // ID H0ZXI1_TAEGU Unreviewed; 100 AA. AC H0ZXI1; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 23-MAY-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTGUP00000015332}; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; OC Estrildidae; Estrildinae; Taeniopygia. OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000015332, ECO:0000313|Proteomes:UP000007754}; RN [1] {ECO:0000313|Proteomes:UP000007754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20360741; DOI=10.1038/nature08819; RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., RA London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B., RA Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., RA Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M., RA Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P., RA Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T., RA Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A., RA Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E., RA Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D., RA Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H., RA Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J., RA Chinwalla A., Hou S., Mardis E.R., Wilson R.K.; RT "The genome of a songbird."; RL Nature 464:757-762(2010). RN [2] {ECO:0000313|Ensembl:ENSTGUP00000015332} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABQF01064030; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSTGUT00000015583; ENSTGUP00000015332; ENSTGUG00000014981. DR GeneTree; ENSGT00530000068158; -. DR InParanoid; H0ZXI1; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000007754; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007754}; KW Reference proteome {ECO:0000313|Proteomes:UP000007754}. FT DOMAIN 2 97 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 100 AA; 11514 MW; 1678CD42D1152FA1 CRC64; RGRYNQSRGS LHTVQGVSSC DLLSNSIHGS HQYGYEGWDF ISFLLGSRSF AVSNGAVWIS QRCWEHKGIM VEQMKHYLGH TCVERPPKYI RYGREALEHK // ID H0ZXI4_TAEGU Unreviewed; 178 AA. AC H0ZXI4; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 23-MAY-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTGUP00000015335}; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; OC Estrildidae; Estrildinae; Taeniopygia. OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000015335, ECO:0000313|Proteomes:UP000007754}; RN [1] {ECO:0000313|Proteomes:UP000007754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20360741; DOI=10.1038/nature08819; RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., RA London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B., RA Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., RA Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M., RA Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P., RA Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T., RA Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A., RA Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E., RA Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D., RA Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H., RA Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J., RA Chinwalla A., Hou S., Mardis E.R., Wilson R.K.; RT "The genome of a songbird."; RL Nature 464:757-762(2010). RN [2] {ECO:0000313|Ensembl:ENSTGUP00000015335} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABQF01064032; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01064033; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0ZXI4; -. DR Ensembl; ENSTGUT00000015586; ENSTGUP00000015335; ENSTGUG00000014985. DR GeneTree; ENSGT00530000068158; -. DR InParanoid; H0ZXI4; -. DR OMA; WKGILER; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000007754; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007754}; KW Reference proteome {ECO:0000313|Proteomes:UP000007754}. FT DOMAIN 3 175 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 178 AA; 19586 MW; FBB66FFBDE0BAB63 CRC64; VLHSLQFLEV ALSEPGPGVP QSLIVGDVDG TPCERCGSER GRMEAQTPGM GAGAELGYWD SQSWDIGTAR AGTLGDLESD RLFSPRSPGL HTVQGVSSCD LLSNSVHGFH QYGYEGWDFI SFQLGSELAV SNSAVWISQR CWESRGIMVE QMKHYLGHTC VERPPKYIRY GREALEHK // ID H0ZY44_TAEGU Unreviewed; 270 AA. AC H0ZY44; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 23-MAY-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTGUP00000015546}; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; OC Estrildidae; Estrildinae; Taeniopygia. OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000015546, ECO:0000313|Proteomes:UP000007754}; RN [1] {ECO:0000313|Proteomes:UP000007754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20360741; DOI=10.1038/nature08819; RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., RA London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B., RA Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., RA Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M., RA Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P., RA Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T., RA Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A., RA Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E., RA Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D., RA Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H., RA Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J., RA Chinwalla A., Hou S., Mardis E.R., Wilson R.K.; RT "The genome of a songbird."; RL Nature 464:757-762(2010). RN [2] {ECO:0000313|Ensembl:ENSTGUP00000015546} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABQF01061136; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01061137; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01061138; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01061139; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01061140; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01061141; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01061142; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01061143; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01061144; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01061145; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0ZY44; -. DR STRING; 59729.ENSTGUP00000015546; -. DR Ensembl; ENSTGUT00000015812; ENSTGUP00000015546; ENSTGUG00000015195. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00530000068158; -. DR InParanoid; H0ZY44; -. DR OMA; AYLEENC; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007754; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007754}; KW Reference proteome {ECO:0000313|Proteomes:UP000007754}. FT DOMAIN 182 266 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 270 AA; 30614 MW; 0C9692A8840BA368 CRC64; VLHSLQFLEV ALSEPGPRVP QSLIVGDVDG TPCERCGSER GWMEAQTPGM GAGAELGYWD RQRPCSRTGT GPWPTVTWRR GRYNQSRGGL HTVQGVSSCD LLSNSVHGSH QYGYEGWDFI SFQLGSGSFA VSNTAVWISQ RCWESRGIMV EQMKHYLGHT YVEGPPKYIR YGREALEHKE PPDAHVYRKV EHGTRALSCH MYGFCPRTIR MSWMKGEEMQ DQEIELGGII PNSNGTFHTW ARAEALPGER EQHWCRVEHP RMLELGILIW // ID H0ZYS3_TAEGU Unreviewed; 100 AA. AC H0ZYS3; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 23-MAY-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTGUP00000015776}; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; OC Estrildidae; Estrildinae; Taeniopygia. OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000015776, ECO:0000313|Proteomes:UP000007754}; RN [1] {ECO:0000313|Proteomes:UP000007754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20360741; DOI=10.1038/nature08819; RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., RA London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B., RA Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., RA Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M., RA Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P., RA Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T., RA Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A., RA Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E., RA Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D., RA Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H., RA Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J., RA Chinwalla A., Hou S., Mardis E.R., Wilson R.K.; RT "The genome of a songbird."; RL Nature 464:757-762(2010). RN [2] {ECO:0000313|Ensembl:ENSTGUP00000015776} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABQF01100214; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSTGUT00000016052; ENSTGUP00000015776; ENSTGUG00000015443. DR GeneTree; ENSGT00530000068158; -. DR InParanoid; H0ZYS3; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000007754; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007754}; KW Reference proteome {ECO:0000313|Proteomes:UP000007754}. FT DOMAIN 2 97 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 100 AA; 11396 MW; D80F118C8EBD4241 CRC64; RGRYNQSRGS LHTVQGVSSC DLLSNSVHGS HQYGYEGWDF ISFLLGSGSF AVSSGALWIS QRCWESRGIM VEQMKHYLGH TCVERPPKYI RYGWEALEHK // ID H0ZYU0_TAEGU Unreviewed; 100 AA. AC H0ZYU0; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 23-MAY-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTGUP00000015793}; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; OC Estrildidae; Estrildinae; Taeniopygia. OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000015793, ECO:0000313|Proteomes:UP000007754}; RN [1] {ECO:0000313|Proteomes:UP000007754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20360741; DOI=10.1038/nature08819; RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., RA London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B., RA Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., RA Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M., RA Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P., RA Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T., RA Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A., RA Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E., RA Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D., RA Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H., RA Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J., RA Chinwalla A., Hou S., Mardis E.R., Wilson R.K.; RT "The genome of a songbird."; RL Nature 464:757-762(2010). RN [2] {ECO:0000313|Ensembl:ENSTGUP00000015793} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABQF01107991; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSTGUT00000016070; ENSTGUP00000015793; ENSTGUG00000015460. DR GeneTree; ENSGT00530000068158; -. DR InParanoid; H0ZYU0; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000007754; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007754}; KW Reference proteome {ECO:0000313|Proteomes:UP000007754}. FT DOMAIN 2 93 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 100 AA; 11396 MW; ADFB218CAF5B0C55 CRC64; RGRYNQSRGS LHTVQGVSSC DLLSNSVHGS HQYGYEGWDF ISFQLGSGSF AVSNTAVWIS QRCWESRGIM VEQMKHYLGH TCVERPPKYI RYGWGALEHK // ID H0ZZ42_TAEGU Unreviewed; 98 AA. AC H0ZZ42; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 23-MAY-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTGUP00000015895}; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; OC Estrildidae; Estrildinae; Taeniopygia. OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000015895, ECO:0000313|Proteomes:UP000007754}; RN [1] {ECO:0000313|Proteomes:UP000007754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20360741; DOI=10.1038/nature08819; RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., RA London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B., RA Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., RA Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M., RA Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P., RA Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T., RA Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A., RA Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E., RA Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D., RA Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H., RA Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J., RA Chinwalla A., Hou S., Mardis E.R., Wilson R.K.; RT "The genome of a songbird."; RL Nature 464:757-762(2010). RN [2] {ECO:0000313|Ensembl:ENSTGUP00000015895} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABQF01062934; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0ZZ42; -. DR Ensembl; ENSTGUT00000016181; ENSTGUP00000015895; ENSTGUG00000015564. DR GeneTree; ENSGT00530000068158; -. DR InParanoid; H0ZZ42; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000007754; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007754}; KW Reference proteome {ECO:0000313|Proteomes:UP000007754}. FT DOMAIN 1 95 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 98 AA; 11284 MW; A7369E7226F07217 CRC64; RYNQSRGSLH TVQGVSSCDL LSNSVHGSHQ YGYEGWDFIS FLLGSRSFAV SSGATWITQR CWESRGIMVE QMKHYLGHTC VERPPKYIRY GWEALEHK // ID H1A228_TAEGU Unreviewed; 101 AA. AC H1A228; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 23-MAY-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTGUP00000016940}; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; OC Estrildidae; Estrildinae; Taeniopygia. OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000016940, ECO:0000313|Proteomes:UP000007754}; RN [1] {ECO:0000313|Proteomes:UP000007754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20360741; DOI=10.1038/nature08819; RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., RA London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B., RA Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., RA Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M., RA Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P., RA Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T., RA Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A., RA Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E., RA Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D., RA Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H., RA Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J., RA Chinwalla A., Hou S., Mardis E.R., Wilson R.K.; RT "The genome of a songbird."; RL Nature 464:757-762(2010). RN [2] {ECO:0000313|Ensembl:ENSTGUP00000016940} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABQF01102415; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSTGUT00000017296; ENSTGUP00000016940; ENSTGUG00000016646. DR GeneTree; ENSGT00530000068158; -. DR InParanoid; H1A228; -. DR OMA; DWINTYM; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000007754; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007754}; KW Reference proteome {ECO:0000313|Proteomes:UP000007754}. FT DOMAIN 2 98 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 101 AA; 11589 MW; 3FF468686A8D522B CRC64; RGRYNQSRGS LHTVQGVSSC DLLSNGSIHG SHQYGYEGWD FISFQLGSGS FAVSNTAVWI SQRCWEHKGI MVEQMKHYLG HTCVERPPKY IRYDREALEH K // ID H1A3T8_TAEGU Unreviewed; 333 AA. AC H1A3T8; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 23-MAY-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTGUP00000017552}; GN Name=LOC100231469 {ECO:0000313|Ensembl:ENSTGUP00000017552}; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; OC Estrildidae; Estrildinae; Taeniopygia. OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000017552, ECO:0000313|Proteomes:UP000007754}; RN [1] {ECO:0000313|Proteomes:UP000007754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20360741; DOI=10.1038/nature08819; RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., RA London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B., RA Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., RA Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M., RA Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P., RA Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T., RA Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A., RA Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E., RA Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D., RA Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H., RA Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J., RA Chinwalla A., Hou S., Mardis E.R., Wilson R.K.; RT "The genome of a songbird."; RL Nature 464:757-762(2010). RN [2] {ECO:0000313|Ensembl:ENSTGUP00000017552} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABQF01057773; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H1A3T8; -. DR STRING; 59729.ENSTGUP00000017552; -. DR Ensembl; ENSTGUT00000017953; ENSTGUP00000017552; ENSTGUG00000017273. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H1A3T8; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007754; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007754}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007754}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 278 302 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 182 259 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 333 AA; 37629 MW; F271A7C0840A3E90 CRC64; VLHSLHYLHV AVSEPSPGVP QFTSIGFVDG IPFVRYDSER GRAEPLTQWM KDGAEPGYWD EETQISVRNQ HVDARNLETL QERYNQSRGL HTALWAYGCD LLSDGSVRGS RRYGYDGRDF ISFDLGSGKF LAADSAAEIT RRRWEQEDMA ERLKNYLKHK CPEWLRKYVG YGQKELERKE PPDVHVSGKE EYGTLILSCH AYGFYPNTIT VSWMKENATL DQEMEWGGIV PNSDGTFHTW ARIEALPEEW EQYRCKVDHP GMLEPGLFAW EPTSGRNLTM AVAVSVIAAI LILTVLIGFG VWKLQSGRRD RSGYNVAAGK DVGMNGSTAG TEE // ID H2L5W4_ORYLA Unreviewed; 332 AA. AC H2L5W4; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 23-MAY-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000001201}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001201}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000001201} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001201}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000001201} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001201}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04062036; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2L5W4; -. DR Ensembl; ENSORLT00000001202; ENSORLP00000001201; ENSORLG00000000983. DR eggNOG; ENOG410KFJH; Eukaryota. DR eggNOG; ENOG4110T8Z; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2L5W4; -. DR OMA; EYFRAYV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000001038; Chromosome 11. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 276 297 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 147 254 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 332 AA; 38506 MW; DD4A11EDD9EA726E CRC64; NLPEYVVTAL MDKVELGNFD SIKREFESKQ DWIKKLFNER PKIFQYYINK CRRNQQLFKA NMDVFKDRLN QTEGSHILQR IGGCEWDDES DEVKGFEQYS YDGEICLDLQ TETWIAPKTQ AIVIKHLWDA DKERLKHIQH MLISMCPKML QDYMHYGRSF LQRTESPSVS FLQKTPSSPV CCHATGFYPD RADLFWRKDG EEIHEGMEKG QILPNHDGTF QMSSELNVSL IKHEDWRRYD CVFQLSGLTE DIVSTLDKTQ IQTNWVSPSE FPVGPVVGGA AGVVLLLVIS GVLYCCWRNR NDVEMSPHGH HPHQMDPQPP GSLEVYKKQA IM // ID H2L643_ORYLA Unreviewed; 339 AA. AC H2L643; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 23-MAY-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000001287}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001287, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000001287, ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001287, RC ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000001287} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001287}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04062115; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2L643; -. DR STRING; 8090.ENSORLP00000001287; -. DR Ensembl; ENSORLT00000001288; ENSORLP00000001287; ENSORLG00000001044. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2L643; -. DR OMA; SCEVIHE; -. DR OrthoDB; EOG091G0BBK; -. DR TreeFam; TF334519; -. DR Proteomes; UP000001038; Chromosome 11. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 316 338 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 212 301 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 339 AA; 39430 MW; 7171DA495C603A90 CRC64; FVACGRRGRG KILKFISLCF SEKHSLTYIY TAFSHPVKLP GIHEFTAMGL LDNRMIDYYD SSVQKKIPKQ DWMKERLQQE YWDKGTQSRQ SKQQWFKVNI DILINRMRQT SNDTHVLQWM HGCEGEEDEQ GNLQFKRGMD MYNYDGDDFL AFDDKHQVWV AAADAAFPTK RKWDDVTALK DYTKGYLEKE CMEWMKTFLS YSKQQLRNAS RPDVYMFFKK AKESSNVVLT CLATGFYPKD ITLNIRRDGR VLTKDDGVMS SGVRPNHDET FQRTDYVEIL RSDSANYTCE IIHPASDMHV VKTWDHHLPP VDKNNLGLYV GIVIGLLVLI LGSIIVFLV // ID H2L659_ORYLA Unreviewed; 335 AA. AC H2L659; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000001303}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001303, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000001303, ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001303, RC ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000001303} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001303}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04062115; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2L659; -. DR STRING; 8090.ENSORLP00000001303; -. DR Ensembl; ENSORLT00000001304; ENSORLP00000001303; ENSORLG00000001056. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2L659; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G0BBK; -. DR TreeFam; TF334519; -. DR Proteomes; UP000001038; Chromosome 11. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 335 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003564563. FT TRANSMEM 309 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 335 AA; 38544 MW; EB00E97CA87C1A6C CRC64; MLITSVLVLL GSGLLVNCEK HSLTYIYTAF SHPVKLPGIH EFTAMGLLDN RMIDYYDSSV QKKIPKQDWM KERLQQEYWD KGTQSRQSKQ QWFKVNIDIL INRMRQTSND THVLQWMHGC EGVEDEHGNL QFKRGMDMYN YDGDDFLAFD DERQVWVAAA DAAVPTKRKW DEVTALKDYT KGYLEKECME WMKTFLSYST QQLRNASRPD VYMFFKKAKE SSNVVLTCLA TGFYPKDITL NIRRDGRVLT KDDGVMSSGV RPNHDETFQR KDYVEILRSD SATYTCEIIH PASNVWVVKT WEGSPGSDIG LVLGLVCGIG GVLAIVVIRV LYKKK // ID H2L661_ORYLA Unreviewed; 196 AA. AC H2L661; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 23-MAY-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000001305}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001305, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000001305, ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001305, RC ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000001305} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001305}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04062121; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04062122; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2L661; -. DR STRING; 8090.ENSORLP00000001305; -. DR Ensembl; ENSORLT00000001306; ENSORLP00000001305; ENSORLG00000001058. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2L661; -. DR OMA; RETRICK; -. DR OrthoDB; EOG091G0BBK; -. DR TreeFam; TF334519; -. DR Proteomes; UP000001038; Chromosome 11. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}. FT DOMAIN 27 196 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 196 AA; 23076 MW; 44EA483235ED8702 CRC64; IKAAPRVSSC YQLCSSRLIN TSCKAVEHSL TYIYTAFSKP VKLPGIHEFT AMGLLDNRMI DYYDSTEQKK IPKQDWMKER LQQEYWDKGT QSRQSKQQWF KVNIDILINR MRQTSNDTHV LQWMHGCVGK EDDNGNIQFK RGMNMYNYDG DDFLRFDDEH QVWVAAADAA FPTKRKWDDV TALKDYTKGY LEKECM // ID H2L674_ORYLA Unreviewed; 353 AA. AC H2L674; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 23-MAY-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000001318}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001318, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000001318, ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001318, RC ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000001318} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001318}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04062127; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSORLT00000001319; ENSORLP00000001318; ENSORLG00000001067. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000001038; Chromosome 11. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 353 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003563955. FT TRANSMEM 325 349 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 217 310 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 353 AA; 40602 MW; 837301FC2ABF8543 CRC64; LPLRPILVVL FLSGLLLFLK DFTMEHSLTY IYTAFSHPVK LPGIHEFTAM GLLDNRMIDY YDSSVQKKIP KQKWMKERLQ PEYWEKGTQS RQSKQQWFKV NIDILINRMR QTSNDTHVLQ WMHGCVGKED DNGNIQFERG MDMYNYDGDD FLRFDDEHQV WVAAADAAFP TKRKWDDVTA LKDYTKGYLE KECMEWMKTF LKYSTEQEKV LSTTKPPEVF MFATPAKKKS NMVLTCFATG FLPKEITMEI KRDLEGKSRV LSADDGLVSS GVRPNEDDTF QRRDHVEILK TDPASYSCRV IHKATNMDVE QAWDHQHPDN DATGIIIGAA AGVVVLIAVG IVAVVIVMLK KKS // ID H2L676_ORYLA Unreviewed; 354 AA. AC H2L676; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 23-MAY-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000001320}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001320, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000001320, ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001320, RC ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000001320} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001320}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04062127; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2L676; -. DR STRING; 8090.ENSORLP00000001320; -. DR Ensembl; ENSORLT00000001321; ENSORLP00000001320; ENSORLG00000001067. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2L676; -. DR OMA; CEGETHP; -. DR OrthoDB; EOG091G0BBK; -. DR TreeFam; TF334519; -. DR Proteomes; UP000001038; Chromosome 11. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 26 45 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 334 353 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 227 320 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 354 AA; 41012 MW; E7E01F3758132BC6 CRC64; LKMTNHRISQ MYPVFIFIQQ TQQIKWLFLL LFAVEHSLTY IYTAFSHPVK LPGIHEFTAM GLLDNRMIDY YDSSVQKKIP KQKWMKERLQ PEYWEKGTQS RQSKQQWFKV NIDILINRMR QTSNDTHVLQ WMHGCVGKED DNGNIQFERG MDMYNYDGDD FLRFDDEHQV WVAAADAAFP TKRKWDDVTA LKDYTKGYLE KECMEWMKTF LKYSTEQEKV LSTTKPPEVF MFATPAKKKS NMVLTCFATG FLPKEITMEI KRDLEGKSRV LSADDGLVSS GVRPNEDDTF QRRDHVEILK TDPASYSCRV IHKATNMDVE QAWDHQHPDN DATGIIIGAA AGVVVLIAVG IVAV // ID H2L677_ORYLA Unreviewed; 223 AA. AC H2L677; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 23-MAY-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000001321}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001321, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000001321, ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001321, RC ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000001321} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001321}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04062127; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSORLT00000001322; ENSORLP00000001321; ENSORLG00000001067. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000001038; Chromosome 11. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 223 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003564566. FT DOMAIN 20 201 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 223 AA; 26351 MW; A5078D1FFB41C837 CRC64; MFFIAAFFVL GTLTSVRSVE HSLTYIYTAF SHPVKLPGIH EFTAMGLLDN RMIDYYDSSV QKKIPKQKWM KERLQPEYWE KGTQSRQSKQ QWFKVNIDIL INRMRQTSND THVLQWMHGC VGKEDDNGNI QFERGMDMYN YDGDDFLRFD DEHQVWVAAA DAAFPTKRKW DDVTALKDYT KGYLEKECME WMKTFLKYST EQEKVLSTTK PPEVFMFATP AKK // ID H2LPU3_ORYLA Unreviewed; 387 AA. AC H2LPU3; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 23-MAY-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000008079}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008079}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000008079} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008079}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000008079} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008079}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04001364; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2LPU3; -. DR Ensembl; ENSORLT00000008080; ENSORLP00000008079; ENSORLG00000006435. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2LPU3; -. DR OrthoDB; EOG091G0BU8; -. DR TreeFam; TF352993; -. DR Proteomes; UP000001038; Chromosome 11. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT DOMAIN 217 303 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 387 AA; 44674 MW; 4E824857BC54074B CRC64; MKCMLLKCDF CLNYYIQKSK KQFNLMSSKH SLEYFCTAAS GVKEFPEFVG VATVDKDFVG SCSMIIHRTE PKSTVIKKFI DENSKQIWWY YTTCKEKERF YASIIDGIKK HLNQNTVKYV FSKHVFQQHS GCEWDDETGE TKSFNRYAYD GEDFLKLDLL KHEWTALTEK AYATKLTWEN NKVSLKHSEY FYSIQCPDWL KKYVTFGREY LQRAVLPLVS LLQRSNSSLV SCHATGFFPD IADLFWMKDG EEFHGDVEKG EILPNNDETF QMSIYLNTSS LPLTDWQKFS CVFQLFSSQK NITVSLDKTK IRTNDATHVM CSGNTDSFTK RHWGAGTALF ILVAMAVSGS NMFKRLLNLQ YCLCSSDKEN KDVNGSICPQ VDVSECN // ID H2LQB4_ORYLA Unreviewed; 341 AA. AC H2LQB4; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000008254}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008254, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000008254, ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008254, RC ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000008254} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008254}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04001385; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001386; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001387; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2LQB4; -. DR STRING; 8090.ENSORLP00000008254; -. DR Ensembl; ENSORLT00000008255; ENSORLP00000008254; ENSORLG00000006575. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2LQB4; -. DR OMA; VPGYYNQ; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000001038; Chromosome 11. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 341 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003565041. FT TRANSMEM 302 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 179 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 341 AA; 38715 MW; 76EE80570FF0F598 CRC64; MKILGVLSVI FLGLYSAAAV VTHSLRYLHS ASSGIPGFPG FVTVVLVDGQ PFSYYDSNIR RELPRQSWMV QTEDPDFWER RTQSSFVNEQ VFKRKVAMIK PRFNLTGGVH VVQLLYGCEW DEETGDIKGQ WQFGHNGEDI LALDLKTNTW MESTTVASFS NKNEDWVIQM NNYLSQGCPD QLKKYVSHGR STLMRTESPS VSLLQKNFLS PVRCHATGFY PNRAVMFWRK DGNEIHAGVE KGEILPNNDG TFQMSVDLKL LSDTPEKEGY ECVFQFSGVN ESIITKLEES NIRTNGPSRY EVMVSAVIAI LIFAAVIADW LILYKRRKAA DHLNKKKQIL L // ID H2LR18_ORYLA Unreviewed; 352 AA. AC H2LR18; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 23-MAY-2018, entry version 42. DE SubName: Full=Major histocompatibility complex class I-related gene protein-like precursor {ECO:0000313|Ensembl:ENSORLP00000008515}; GN Name=orla-uaa {ECO:0000313|Ensembl:ENSORLP00000008515}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008515, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000008515, ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008515, RC ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000008515} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008515}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04001391; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001392; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001393; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001394; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001395; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001396; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001397; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001398; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001399; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2LR18; -. DR Ensembl; ENSORLT00000008516; ENSORLP00000008515; ENSORLG00000006772. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000001038; Chromosome 11. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 352 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003564029. FT TRANSMEM 302 324 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 352 AA; 39843 MW; 2DAC945D4B038369 CRC64; MKIQLILCFL GLSFHGAAAV SHSLKYFYTA SSQVPNFPEF VSVGLVDDAQ ISHYDSDTRM TVPKQDWMAM DEQYWKRQTD IGLGHQQTFK ANIEILKPRF NQTGGVHVFQ WMYGCEWDEE TGAVNSFHQY GYDGEDFIAL DLKTESWIAP KQQAEITKHK WDNDKALMAG RKNYLTQICP EWLKKYVNYG SSSLMRKVLP SVSLLQKSSS SAVSCHATGF YPDRAELLWR RDGEEIHEGV EKGQILPNND GTFQMSVHLQ PPSGEDMQRY ECVFQLSGVK EDVITKLEKA KIRTNEGSSS QMLIIIGVLA AVMAVVAVSA FIFYKKKNVS DLTAVDNKEI QEQMLQPENP SA // ID H2LR19_ORYLA Unreviewed; 334 AA. AC H2LR19; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 23-MAY-2018, entry version 41. DE SubName: Full=Major histocompatibility complex class I-related gene protein-like precursor {ECO:0000313|Ensembl:ENSORLP00000008516}; GN Name=orla-uaa {ECO:0000313|Ensembl:ENSORLP00000008516}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008516, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000008516, ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008516, RC ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000008516} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008516}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04001391; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001392; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001393; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001394; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001395; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001396; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001397; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001398; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001399; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSORLT00000008517; ENSORLP00000008516; ENSORLG00000006772. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000001038; Chromosome 11. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 334 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003565286. FT TRANSMEM 302 324 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 334 AA; 37949 MW; 644EA5AD236C89CC CRC64; MKIQLILCFL GLSFHGAAAV SHSLKYFYTA SSQVPNFPEF VSVGLVDDAQ ISHYDSDTRM TVPKQDWMAM DEQYWKRQTD IGLGHQQTFK ANIEILKPRF NQTGGVHVFQ WMYGCEWDEE TGAVNSFHQY GYDGEDFIAL DLKTESWIAP KQQAEITKHK WDNDKALMAG RKNYLTQICP EWLKKYVNYG SSSLMRKVLP SVSLLQKSSS SAVSCHATGF YPDRAELLWR RDGEEIHEGV EKGQILPNND GTFQMSVHLQ PPSGEDMQRY ECVFQLSGVK EDVITKLEKA KIRTNEGSSS QMLIIIGVLA AVMAVVAVSA FIFYKKKNVK IYLQ // ID H2LR42_ORYLA Unreviewed; 360 AA. AC H2LR42; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 23-MAY-2018, entry version 51. DE SubName: Full=Classical MHC class I molecule, alpha-chain {ECO:0000313|EMBL:BAJ07297.2}; DE SubName: Full=Major histocompatibility complex class I-related gene protein-like precursor {ECO:0000313|Ensembl:ENSORLP00000008539}; GN Name=orla-uba {ECO:0000313|Ensembl:ENSORLP00000008539}; GN Synonyms=Orla-UBA {ECO:0000313|EMBL:BAJ07297.2}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008539, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000008539, ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008539, RC ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|EMBL:BAJ07297.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Hd-rR {ECO:0000313|EMBL:BAJ07297.2}; RX PubMed=20174921; DOI=10.1007/s00251-010-0426-3; RA Nonaka M.I., Nonaka M.; RT "Evolutionary analysis of two classical MHC class I loci of the medaka RT fish, Oryzias latipes: haplotype-specific genomic diversity, locus- RT specific polymorphisms, and interlocus homogenization."; RL Immunogenetics 62:319-332(2010). RN [3] {ECO:0000313|Ensembl:ENSORLP00000008539} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008539}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04001401; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001402; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001403; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001404; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001405; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001406; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AB450999; BAJ07297.2; -; mRNA. DR RefSeq; NP_001265807.2; NM_001278878.2. DR RefSeq; XP_011479270.1; XM_011480968.1. DR STRING; 8090.ENSORLP00000008539; -. DR Ensembl; ENSORLT00000008540; ENSORLP00000008539; ENSORLG00000006798. DR GeneID; 101166971; -. DR KEGG; ola:101166971; -. DR CTD; 101166971; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; H2LR42; -. DR KO; K06751; -. DR OMA; SALTKTW; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000001038; Chromosome 11. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 360 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014574546. FT TRANSMEM 304 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 360 AA; 40733 MW; F59C80F24BCD8E38 CRC64; MKIQMFLCFL GLSFHSAAAV THSLKYFYTA SSQVPTLPEF VAVGLVDDAQ IDYYDSDIRM VVPKQDWMKE AMDGQYWKTE TENRLGDQHT FKARIEILKQ SFNQTGGAHV VQNMYGCEWD DETGEVKGYD QYGYDGEDFI ALDLKSESWI AAKQQAVITK DEWDDNKAFT VGRKNYLTQI CPEWLEKYVN YGSSSLMRKV PPSVSLLQKS SSSAVSCHAT GFYPDRAELL WRRDGEEIHE GVEKGQILPN NDGTFQMSVD LQPPSGEDMQ RYECVFQLSG VKEDVITKLE KAKIRTNEGS SSQMLIIIGV LVAVIAVVLS VSAFIFYKKM NFFNLVKPPP SPVDNKEIQQ QMLQPENPSA // ID H2LR44_ORYLA Unreviewed; 335 AA. AC H2LR44; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 23-MAY-2018, entry version 38. DE SubName: Full=Major histocompatibility complex class I-related gene protein-like precursor {ECO:0000313|Ensembl:ENSORLP00000008541}; GN Name=orla-uba {ECO:0000313|Ensembl:ENSORLP00000008541}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008541, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000008541, ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008541, RC ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000008541} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008541}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04001401; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001402; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001403; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001404; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001405; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001406; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2LR44; -. DR Ensembl; ENSORLT00000008542; ENSORLP00000008541; ENSORLG00000006798. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000001038; Chromosome 11. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 335 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003564032. FT TRANSMEM 304 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 335 AA; 38252 MW; 7314148BB3484F07 CRC64; WFTLNLLLIF AKFHIHKLTH SLKYFYTASS QVPTLPEFVA VGLVDDAQID YYDSDIRMVV PKQDWMKEAM DGQYWKTETE NRLGDQHTFK ARIEILKQSF NQTGGAHVVQ NMYGCEWDDE TGEVKGYDQY GYDGEDFIAL DLKSESWIAA KQQAVITKDE WDDNKAFTVG RKNYLTQICP EWLEKYVNYG SSSLMRKVPP SVSLLQKSSS SAVSCHATGF YPDRAELLWR RDGEEIHEGV EKGQILPNND GTFQMSVDLQ PPSGEDMQRY ECVFQLSGVK EDVITKLEKA KIRTNEGRID SSQMLIIIGV LVAVIAVVLS VSAFIFYKKM NCKLL // ID H2MAI2_ORYLA Unreviewed; 371 AA. AC H2MAI2; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000015536}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000015536, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000015536, ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015536, RC ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000015536} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015536}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04052119; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 8090.ENSORLP00000015536; -. DR Ensembl; ENSORLT00000015537; ENSORLP00000015536; ENSORLG00000012414. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2MAI2; -. DR OMA; GINDRTE; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000001038; Chromosome 22. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 371 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003565965. FT TRANSMEM 315 337 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 216 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 371 AA; 42084 MW; F576D2BD228695B2 CRC64; MRILGVLSVI FFGMNSATAV THSLRYLHTA ASGIPAFPEF VTVVLVDGQP FSYYDSSIKR ELPRQTWTVQ TEDPNFWERR TKSSIVDEQV FKSKVEMIKP SFNQTGGVHI IQLMYGCEWD DETGSIKGWW QFGYNGEDLM ALDLKTNTGT AQTPAATFHK HKKDKDKGWA IRMNTYLSQG CPDHLKKYVS YGKSTLLRTA ETPSVFLLQK NFLSPVRCHA TGFYPNRAVM FWRKDGKEIT EGVETGEILP NNDGTFQMST DLKLLLDTTE KKRYECVFQL SGANESIITK LEQSKIKTNG GKWKTGISVA NPYEVTISVV IAVIIFAAVI ADWLIVYKGR KEFSQIKNKS GINDRTEKKK REEERGKLER G // ID H2MAI6_ORYLA Unreviewed; 355 AA. AC H2MAI6; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000015540}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000015540, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000015540, ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015540, RC ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000015540} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015540}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04052119; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2MAI6; -. DR Ensembl; ENSORLT00000015541; ENSORLP00000015540; ENSORLG00000012414. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000001038; Chromosome 22. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 355 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003565937. FT TRANSMEM 305 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 215 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 355 AA; 40314 MW; 833092A512EBE002 CRC64; MRILGVLSVI FFGMNSATAV THSLRYLHTA ASGIPAFPEF VTVVLVDGQP FSYYDSSIKR ELPRQTWTVQ TEDPNFWERR TKSSIVDEQV FKSKVEMIKP SFNQTGGVHI IQLMYGCEWD DETGSIKGWW QFGYNGEDLM ALDLKTNTGT AQTPAATFHK HKKDKDKGWA IRMNTYLSQG CPDHLKKYVS YGKSTLLRTE TPSVFLLQKN FLSPVRCHAT GFYPNRAVMF WRKDGKEITE GVETGEILPN NDGTFQMSTD LKLLLDTTEK KRYECVFQLS GANESIITKL EQSKIKTNGA NPYEVTISVV IAVIIFAAVI ADWLIVYKGR KDSFYIDFFA GPDGKEEEGR REREV // ID H2MAI9_ORYLA Unreviewed; 337 AA. AC H2MAI9; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000015544}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000015544, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000015544, ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015544, RC ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000015544} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015544}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04052119; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSORLT00000015545; ENSORLP00000015544; ENSORLG00000012414. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000001038; Chromosome 22. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 337 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003565967. FT TRANSMEM 305 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 215 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 337 AA; 38192 MW; FCE5EB7B2D67C7F1 CRC64; MRILGVLSVI FFGMNSATAV THSLRYLHTA ASGIPAFPEF VTVVLVDGQP FSYYDSSIKR ELPRQTWTVQ TEDPNFWERR TKSSIVDEQV FKSKVEMIKP SFNQTGGVHI IQLMYGCEWD DETGSIKGWW QFGYNGEDLM ALDLKTNTGT AQTPAATFHK HKKDKDKGWA IRMNTYLSQG CPDHLKKYVS YGKSTLLRTE TPSVFLLQKN FLSPVRCHAT GFYPNRAVMF WRKDGKEITE GVETGEILPN NDGTFQMSTD LKLLLDTTEK KRYECVFQLS GANESIITKL EQSKIKTNGA NPYEVTISVV IAVIIFAAVI ADWLIVYKGR KVNIRLL // ID H2MRT0_ORYLA Unreviewed; 368 AA. AC H2MRT0; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 23-MAY-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000021462}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000021462}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000021462} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000021462}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000021462} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000021462}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04085979; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04085980; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04085981; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2MRT0; -. DR STRING; 8090.ENSORLP00000021462; -. DR Ensembl; ENSORLT00000021463; ENSORLP00000021462; ENSORLG00000017153. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2MRT0; -. DR OMA; RREPWYL; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000001038; Chromosome 8. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 368 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003566568. FT TRANSMEM 308 335 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 42228 MW; 5A384CFB2B7E7E5B CRC64; MKIQMFLCFL GLSFHGAAAV SHSLKILFIG PFPVQNLPGF IILVLVDDVL MTYYDSNITT MVPRQDWLKE VVDEEFWKSY TKISLYAQQT FIGDIERAKQ LYNQTEGVLV VQLMCGCEWD EETGEVKGYS QLGYDGEDFL SFDLKTESWT AANQFAEIMK HQWDNNKPFN AGWKNDLDEI FPKWLKEFVN LGRRFLMRTV LPSVSLLQKS SSSPVSCHAT GFYPDRADLF WRRDGEEIHE GVKKGQILPN NDGTFQMSVD LQLPPEAETH RYECVFQLSG VKEDVITELE KEQINTNEGI TNLRKFSFLL SASLIVAVFQ KCSCCFLLTA IIVYYRKKAI CPTLAKKEQN KSPKRQTRRP EDSSLPNT // ID H2MWX4_ORYLA Unreviewed; 331 AA. AC H2MWX4; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000023398}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000023398, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000023398} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000023398}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSORLT00000023399; ENSORLP00000023398; ENSORLG00000018729. DR eggNOG; ENOG410KFJH; Eukaryota. DR eggNOG; ENOG4110T8Z; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000001038; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 296 317 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 187 274 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 331 AA; 38097 MW; FBB38CC0AA47691A CRC64; SSVKHSLKWI ITATSGITNL PKFVVTASVD KVEFGHFDSI KREFEPKQEW TRKLFKEKPE LFQLGLQSCL YDQHFFKAYL DVFKERLNQT EGSHILQRIG GCEWDDESDE VKGFQQYGYD GEDFISLDLQ TETWIAPKTQ AVVIKHLWDA DKERIKHIQH MLMSECPKSL QDHMLYGRSF LQRTESPSVS FLQKTPSSPV CCHATGFYPD RADLFWRKDG EEIHEGVEKG QILPNHDGTF QMSSELNVSL IKHEDWRRYD CVFQLSGLTE DIVSMLDKTQ IQTNWVSPSE FPVGPVVGGA AGVVLLLVIS GVLCCCWRNR NDENKKKKFL L // ID H2MWX7_ORYLA Unreviewed; 372 AA. AC H2MWX7; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000023402}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000023402, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000023402} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000023402}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H2MWX7; -. DR Ensembl; ENSORLT00000023403; ENSORLP00000023402; ENSORLG00000018729. DR eggNOG; ENOG410KFJH; Eukaryota. DR eggNOG; ENOG4110T8Z; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2MWX7; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000001038; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 312 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 193 280 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 372 AA; 42658 MW; 722395A10E7E6882 CRC64; KSHAILSSVK HSLKWIITAT SGITNLPKFV VTASVDKVEF GHFDSIKREF EPKQEWTRKL FKEKPELFQL GLQSCLYDQH FFKAYLDVFK ERLNQTEGSH ILQRIGGCEW DDESDEVKGF QQYGYDGEDF ISLDLQTETW IAPKTQAVVI KHLWDADKER IKHIQHMLMS ECPKSLQDHM LYGRSFLQRT ESPSVSFLQK TPSSPVCCHA TGFYPDRADL FWRKDGEEIH EGVEKGQILP NHDGTFQMSS ELNVSLIKHE DWRRYDCVFQ LSGLTEDIVS MLDKTQIQTN WGKIFDPCFY SVSPSEFPVG PVVGGAAGVV LLLVISGVLC CCWRNRNVSD FQPVNGKCFL SSHLISFVFG TIDKQKVKCE RR // ID H2MZ76_ORYLA Unreviewed; 350 AA. AC H2MZ76; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000024359}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000024359, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000024359} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000024359}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H2MZ76; -. DR Ensembl; ENSORLT00000024360; ENSORLP00000024359; ENSORLG00000019579. DR eggNOG; ENOG410KFJH; Eukaryota. DR eggNOG; ENOG4110T8Z; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2MZ76; -. DR OMA; QPRFIAV; -. DR OrthoDB; EOG091G0GOV; -. DR TreeFam; TF352993; -. DR Proteomes; UP000001038; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 312 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 303 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 350 AA; 39563 MW; 2BC06C608A8A7E03 CRC64; VLSVQLHSVE EMMKMFITLF FLCHAASAVK HSLILIFTGI SGETNLPEVA ISGSVDKVEI CHFDSIKREV EPKQDWTRKL FKEKPELLQL TLKRLLFHQQ LFKDDMDIFK QRLNQTEGSH ILQTITGCEW DDESNEVKGF IQFGHDGEDF ISLDLQTGTW IASKTQAVVI KIYGMQTKGD LGTFNTYSCQ SVLKTSGSHA LLEFLCPERP SVSFLQKTPS SLVCCHATGF YPDRADLFWR KDGEEIHEGM EKGQILPNHD GTFQMSSELN VSLIKHEDWR RYDCVFQLSG LAEDIVSTLD KISPSEFPVG PVVGGAAGVV LLLVISGVLY CCWRNRNDFQ PVDERFTRST // ID H2N113_ORYLA Unreviewed; 262 AA. AC H2N113; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000025097}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000025097, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000025097} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025097}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSORLT00000025098; ENSORLP00000025097; ENSORLG00000020236. DR eggNOG; ENOG410JB3C; Eukaryota. DR eggNOG; ENOG4111519; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2N113; -. DR OMA; VEHESLL; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000001038; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 205 224 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 98 183 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 262 AA; 29876 MW; DB0FF631711D1488 CRC64; SSGVHAFQYM YGCEWDDETG EVKGYRQYGY DGEDFIVYDL KMESWTAPKQ QAEITKHKWE NDKDFMAFLK NYLSQECPEW LKKYVNDGRS SLMRKVLPSV SLLQKSSSSP VSCHATGFFP HRAELLWRRD GEKIHDGVEK GWILPNNDGT FQMSVDLQLP SEEDMQRYEC VFQLSGVKQD IITKLEKAKI RTNEGIIDSN SSSQMLIITA VIAAVLAVTA FILYKKKNPK RPPARKESTN KTQKLPLSPD SNVNLSLAFS SI // ID H2N114_ORYLA Unreviewed; 241 AA. AC H2N114; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000025098}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000025098, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000025098} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025098}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSORLT00000025099; ENSORLP00000025098; ENSORLG00000020236. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000001038; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 198 217 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 96 181 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 241 AA; 27797 MW; E9661799F887F3EC CRC64; GVHAFQYMYG CEWDDETGEV KGYRQYGYDG EDFIVYDLKM ESWTAPKQQA EITKHKWEND KDFMAFLKNY LSQECPEWLK KYVNDGRSSL MRKVLPSVSL LQKSSSSPVS CHATGFFPHR AELLWRRDGE KIHDGVEKGW ILPNNDGTFQ MSVDLQLPSE EDMQRYECVF QLSGVKQDII TKLEKAKIRT NEDSSSQMLI ITAVIAAVLA VTAFILYKKK NPKRPPAPVE NKEVQQQMVP E // ID H2N1C6_ORYLA Unreviewed; 307 AA. AC H2N1C6; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000025226}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000025226, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000025226} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025226}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSORLT00000025227; ENSORLP00000025226; ENSORLG00000020349. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000001038; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}. FT DOMAIN 207 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 307 AA; 36079 MW; 742B1FBC93A527AB CRC64; IKSEDLIIII VSLKKSDAFF SLVKHSLKWI TTGISGKTNL PEFVVTASMD NVDLWHCDST KRELEPKQEW TRKLFKFRPE LLQFHLQRCL FNQQFFKAHM DVFKQRLNQT EGSHILQRIG GCEWDDESDE VKGFEQYGYD GEDFISLDLK TGTWVAPKTQ AAVIKHSWDA DKERIKYIQQ IFMSWFPKFL KDYMPYRRSF LQRTERPSVS FLQKTPSSPV CCHATGFYPD RADLFWRKDG EEIHEGVEKG QILPNHDGTF QMSSELNVSL IKHEDWRRYD CVFQLSGLTE DIVSMLDKTQ IQTNWGK // ID H2N1C7_ORYLA Unreviewed; 316 AA. AC H2N1C7; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000025227}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000025227, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000025227} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025227}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 8090.ENSORLP00000025227; -. DR Ensembl; ENSORLT00000025228; ENSORLP00000025227; ENSORLG00000020349. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2N1C7; -. DR OMA; MKNATQT; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000001038; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}. FT DOMAIN 219 306 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 316 AA; 37144 MW; 0DB75DC3968987DF CRC64; LKMNILKCCF KIMNSFLKQN EKSDAFFSLV KHSLKWITTG ISGKTNLPEF VVTASMDNVD LWHCDSTKRE LEPKQEWTRK LFKFRPELLQ FHLQRCLFNQ QFFKAHMDVF KQRLNQTEGK VCSGSHILQR IGGCEWDDES DEVKGFEQYG YDGEDFISLD LKTGTWVAPK TQAAVIKHSW DADKERIKYI QQIFMSWFPK FLKDYMPYRR SFLQRTERPS VSFLQKTPSS PVCCHATGFY PDRADLFWRK DGEEIHEGVE KGQILPNHDG TFQMSSELNV SLIKHEDWRR YDCVFQLSGL TEDIVSMLDK TQIQTN // ID H2N1H0_ORYLA Unreviewed; 322 AA. AC H2N1H0; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000025273}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000025273, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSORLP00000025273} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025273}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H2N1H0; -. DR STRING; 8090.ENSORLP00000025273; -. DR Ensembl; ENSORLT00000025274; ENSORLP00000025273; ENSORLG00000020395. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2N1H0; -. DR OMA; NTRICKA; -. DR OrthoDB; EOG091G0BBK; -. DR TreeFam; TF334519; -. DR Proteomes; UP000001038; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 302 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 322 AA; 37179 MW; BFC85D96B20F1AA8 CRC64; LCFSPVSFPE KHSLTYIYTA FSHPVKLPGI HEFTAMGLLD NRMIDYYDSS VQKKIPKQDW MKERLQQEYW EKGTQSRQSK QQWFKVNIDI LINRMRQTSN DTHVLQWMHG CEGVEDGHGN LQFMSGVDMY NYDGDDFLAF DDEHQIWVAT LDAAVPTKRK WDEVTALKDY TKGYLEKECM EWMNTFLSYS KQQLKSASSP DVFLFASEAK EKANVVLTCL ATGFYPKDIT MNIRRDGRIL TKDDGVVSSG VRPNQDDTHQ RRDHVEILRT DVASYTCEII HPGSNMHVEK PWDHRLPTEE NFPIAPTAAI AVILVLIGII LF // ID H2NZN4_PONAB Unreviewed; 365 AA. AC H2NZN4; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 37. DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSPPYP00000011477}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSPPYP00000011477}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000011477, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000011477, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000011477} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01391580; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01391581; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01391582; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01391583; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01391584; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9601.ENSPPYP00000011477; -. DR Ensembl; ENSPPYT00000011920; ENSPPYP00000011477; ENSPPYG00000010253. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2NZN4; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001595; Chromosome 19. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019864; F:IgG binding; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003567260. FT TRANSMEM 298 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 39774 MW; B7591A943AEF263A CRC64; MGVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLK YNSLRGEAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE AFKALGGKGP YTLQGLLGCE LGPDNTSVPT AKFALNGEEF MNFDLKQGTW GGDWPEALAV SQRWQQQDKA ANKELTFLLF SCPHRLREHL ERGRGNLEWK EPPSMRLKAR PSSPGFSVLT CSAFSFYPPE LQLRFQRNGL AAGTGQGDFG PNSDGSFHAS SSLIVKSGDE HHYCCVVQHA GLAQPLRVEL ESPAETSVLV VGIVIGVLLL MAAAVGGALL WRRMRSGLPA PWISLRGDDT GALLPTPGEA QDADSKDVNV IPATA // ID H2PI54_PONAB Unreviewed; 348 AA. AC H2PI54; A0A2J8S4V7; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 23-MAY-2018, entry version 44. DE SubName: Full=HFE isoform 7 {ECO:0000313|EMBL:PNJ15801.1}; DE SubName: Full=Hemochromatosis {ECO:0000313|Ensembl:ENSPPYP00000018234}; GN Name=HFE {ECO:0000313|Ensembl:ENSPPYP00000018234}; GN ORFNames=CR201_G0046176 {ECO:0000313|EMBL:PNJ15801.1}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000018234, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000018234, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000018234} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|EMBL:PNJ15801.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Susie {ECO:0000313|EMBL:PNJ15801.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., RA Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C., RA Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V., RA Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S., RA Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I., RA Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01197352; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01197353; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; NDHI03003609; PNJ15801.1; -; Genomic_DNA. DR RefSeq; XP_002816556.1; XM_002816510.2. DR ProteinModelPortal; H2PI54; -. DR STRING; 9601.ENSPPYP00000018234; -. DR Ensembl; ENSPPYT00000018959; ENSPPYP00000018234; ENSPPYG00000016305. DR GeneID; 100436892; -. DR KEGG; pon:100436892; -. DR CTD; 3077; -. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2PI54; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl. DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:Ensembl. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl. DR GO; GO:0030881; F:beta-2-microglobulin binding; IEA:Ensembl. DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl. DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0071281; P:cellular response to iron ion; IEA:Ensembl. DR GO; GO:0042446; P:hormone biosynthetic process; IEA:Ensembl. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:Ensembl. DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IEA:Ensembl. DR GO; GO:1904283; P:negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:Ensembl. DR GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; IEA:Ensembl. DR GO; GO:1900121; P:negative regulation of receptor binding; IEA:Ensembl. DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; IEA:Ensembl. DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR GO; GO:1904434; P:positive regulation of ferrous iron binding; IEA:Ensembl. DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl. DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl. DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IEA:Ensembl. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; IEA:Ensembl. DR GO; GO:1900390; P:regulation of iron ion import; IEA:Ensembl. DR GO; GO:2000008; P:regulation of protein localization to cell surface; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 348 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014575076. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 348 AA; 39979 MW; 22010D64CF9269E1 CRC64; MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGASEQ DLGLSLFEAL GYVDDQLFVF YDHESRRVEP RTPWVSSRTS SQMWLQLSQS LKGWDHMFTV DFWTIMENHN HSKESHTLQV ILGCEMQEDN STEGHWKYGY DGQDHLEFCP DTLDWRAAEP GAWPTKLEWE RHKIRARQNR AYLERDCPAQ LQQLLELGRG VLDQQVPPLV KVTHHVTSSV TTLRCRALNY YPQNITMKWL KDRQPMDAKE FEPKDVLPNG DGTYQGWITL AVPPGEEQRY TCQVEHPGLD QPLLAIWEPL PSGTLVIGVI SGIAVFVVIL FIGILSIILR KRQVSRGAMG HYVLAERE // ID A0A2J8SJQ8_PONAB Unreviewed; 346 AA. AC A0A2J8SJQ8; H2PID6; DT 25-APR-2018, integrated into UniProtKB/TrEMBL. DT 25-APR-2018, sequence version 1. DT 23-MAY-2018, entry version 2. DE SubName: Full=HLA-F isoform 4 {ECO:0000313|EMBL:PNJ21008.1}; DE SubName: Full=HLA-F isoform 6 {ECO:0000313|EMBL:PNJ21010.1}; DE SubName: Full=HLA-F isoform 7 {ECO:0000313|EMBL:PNJ21011.1}; GN ORFNames=CR201_G0042450 {ECO:0000313|EMBL:PNJ21011.1}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|EMBL:PNJ21011.1}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000018330, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000018330} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|EMBL:PNJ21011.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Susie {ECO:0000313|EMBL:PNJ21011.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., RA Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C., RA Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V., RA Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S., RA Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I., RA Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01076351; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; NDHI03003564; PNJ21008.1; -; Genomic_DNA. DR EMBL; NDHI03003564; PNJ21010.1; -; Genomic_DNA. DR EMBL; NDHI03003564; PNJ21011.1; -; Genomic_DNA. DR STRING; 9601.ENSPPYP00000018330; -. DR Ensembl; ENSPPYT00000019061; ENSPPYP00000018330; ENSPPYG00000016398. DR eggNOG; ENOG410IUXN; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR OMA; RITQRFY; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 346 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014560316. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 346 AA; 39070 MW; 37B6893E8B11D999 CRC64; MAPRTLLLLL SGALALTETW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRA PWVEQEGPQY WEWTTGYAKA NAQTDRVALK NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRIY LEGECLELLR RYLENGKETL QRADPPKAHI AHHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPTGDG TFQKWAAVVV PSGEEQRYTC HVQHKGLPEP LTLRWEQSPQ PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAM // ID H2PID7_PONAB Unreviewed; 164 AA. AC H2PID7; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000018331}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000018331, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000018331, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000018331} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01076356; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPPYT00000019062; ENSPPYP00000018331; ENSPPYG00000016399. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G0ANY; -. DR TreeFam; TF342166; -. DR Proteomes; UP000001595; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 164 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003568616. FT DOMAIN 25 106 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 86 106 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 164 AA; 18439 MW; 94B198D49E52FA4F CRC64; MELSLVLLFL TCTALFAPQG AAAEPHSLHY NLTVLSWDGS VQSGFLAEGH LDGQLFLLCD RQKGRAGPRG QWAEAVLGAE TWDTETKDLT ENEQELRRTL AHIKDQRGGR GDKYMKVLFD TFNREERDSV TDQCWVSSSC NFRTTMNTKR ILKTQSCLES GSHL // ID H2PID8_PONAB Unreviewed; 365 AA. AC H2PID8; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000018332}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000018332, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000018332, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000018332} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01230006; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9601.ENSPPYP00000018332; -. DR Ensembl; ENSPPYT00000019065; ENSPPYP00000018332; ENSPPYG00000016402. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H2PID8; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003568944. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 40820 MW; 6426440814576648 CRC64; MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFITVG YVDDTQFVRF DSDAASPRME PRAPWIEQEG PEYWDRETRS AKAHAQTDRV DLGTLRGYYN QSDGGSHTIQ RMYGCDVGPD GRFLRGYRQY AYDGKDYIAL NGDLRSWTAA DMAAQITQRK WEAAGEAEQR RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHRISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGKEQR YTCLVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLVLLGA VITGAVVAAV MWRRRSSDRK GGSYSQAASN DSAQGSDVSL TACKV // ID H2PIE5_PONAB Unreviewed; 326 AA. AC H2PIE5; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000018339}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000018339, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000018339, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000018339} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01234977; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPPYT00000019073; ENSPPYP00000018339; ENSPPYG00000016406. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2PIE5; -. DR OMA; FWEENAM; -. DR OrthoDB; EOG091G0ANY; -. DR TreeFam; TF342166; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 275 299 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 193 257 IGc1. {ECO:0000259|SMART:SM00407}. SQ SEQUENCE 326 AA; 35963 MW; A216D7FD88BE1C86 CRC64; PHSLHYNLTV LSQDGSLSGF LAEGHLNGQP FLLYDRQTGK APRGQLAEAV LGAETWDTET EDLTENGQDL RRTLTHIKGQ KGALHSLQEI RVCEIHEDSS TKGSWHFYYD GELFLSQNLE TQEWTVPQSS RAQTLAMNIR NFWDEDATQA KHFHPVMADC LQKLQQERKP SGLGLPYLPP SLPILENSAS ENKVTPTCWA SGFYPQNISL AWCQDAQQSV GVLPNGNGTY QTGVATKIPQ GEERVTSYVG HSRNHSTYAG ALWESPGASE SMATIPYVAA AAAAAFVIII IIILCVFWYK KKISAAEDPE HMSLRSPDQH LVGTGD // ID H2PIE6_PONAB Unreviewed; 280 AA. AC H2PIE6; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 28-MAR-2018, entry version 35. DE SubName: Full=Major histocompatibility complex, class I, E {ECO:0000313|Ensembl:ENSPPYP00000018340}; GN Name=HLA-E {ECO:0000313|Ensembl:ENSPPYP00000018340}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000018340, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000018340, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000018340} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01234959; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01234960; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPPYT00000019074; ENSPPYP00000018340; ENSPPYG00000016407. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 240 265 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 141 229 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 280 AA; 31992 MW; F91912E1531C3F96 CRC64; MVPRAQWMEQ EGPEYWDRET RSARDTAQTF RVNLRTLRGY YNQTEAGSHT LQWMHGCDLG PDGRFLRGYE QFAYDGKDYL TLNEDLRSWT AVDTAAQISE RKSNDACEAE HQRAYLEDTC VEWLRKYLEK GKETLLHLDP PKTHVTHHRI SDHEATLRCW ALGFYPAEIT LTWQRDGEDQ NQYTELVETR PAGDGTFQKW AAVVVPSGEE QRYTCHVQHE GLPEPLTLRW EPASQTTIPI VGIFAGLVLL GAVVTGATVV AAVMWRKKSS GGEGMSYPRE // ID H2PIE7_PONAB Unreviewed; 387 AA. AC H2PIE7; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 28-MAR-2018, entry version 37. DE SubName: Full=Major histocompatibility complex, class I, E {ECO:0000313|Ensembl:ENSPPYP00000018341}; GN Name=HLA-E {ECO:0000313|Ensembl:ENSPPYP00000018341}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000018341, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000018341, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000018341} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01234959; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01234960; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2PIE7; -. DR STRING; 9601.ENSPPYP00000018341; -. DR Ensembl; ENSPPYT00000019075; ENSPPYP00000018341; ENSPPYG00000016407. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H2PIE7; -. DR OMA; EDRTHNT; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 348 373 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 249 337 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 387 AA; 43682 MW; A6588785B9CB6FFB CRC64; MTQTQFSFPV GVGFLEKPIS VATTPDYKVS TRIQETQDSE TGIMTHGTLL LLLSEALALT ETWAGSHSLK YFHTSVSRPG RGEPRFISVG YVDDTQFVRF DNDAASPRMV PRAQWMEQEG PEYWDRETRS ARDTAQTFRV NLRTLRGYYN QTEAGSHTLQ WMHGCDLGPD GRFLRGYEQF AYDGKDYLTL NEDLRSWTAV DTAAQISERK SNDACEAEHQ RAYLEDTCVE WLRKYLEKGK ETLLHLDPPK THVTHHRISD HEATLRCWAL GFYPAEITLT WQRDGEDQNQ YTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP ASQTTIPIVG IFAGLVLLGA VVTGATVVAA VMWRKKSSGG EGMRSGV // ID H2PIH0_PONAB Unreviewed; 364 AA. AC H2PIH0; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000018367}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000018367, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000018367, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000018367} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01202072; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01202073; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9601.ENSPPYP00000018367; -. DR Ensembl; ENSPPYT00000019101; ENSPPYP00000018367; ENSPPYG00000016427. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H2PIH0; -. DR OMA; QRVYGCD; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003568947. FT TRANSMEM 304 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 227 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 40046 MW; 8FEFF683076A1491 CRC64; MRAMAPRTLL LLLSGALALT ETWAGSHSMR YFYTAVSRPG RGDPRFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDQETQS YKRQAQYDRV SLRNLRGYYN QSEDGSHTIQ SMYGCYVGPD GRLLSGYNQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQW RAYLEGLCVG SLRRYLENGK ETLQRTGTRG SGEPSPSPIV SSEGPLCSLG QLRDEITLTW QRDGEDQTQD SEIVETRPAG DGTFQKWAAV VVPSGQEQRY ACHVQHEGPE PITLRWEPSS QSTITIVGIV AGLAVLVVLA VLGAVVTTVM CRRKSSGGKG GSCSQAACNN SAQGSDESLI ACKG // ID H2PIH2_PONAB Unreviewed; 274 AA. AC H2PIH2; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 28-MAR-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000018369}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000018369, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000018369, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000018369} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01191071; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPPYT00000019103; ENSPPYP00000018369; ENSPPYG00000016428. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000001595; Chromosome 6. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}. FT DOMAIN 184 273 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 274 AA; 31454 MW; E028DB0B74F2130F CRC64; EPHSLRYNLT VLSQDGSVQS GFLAEVHLDG QPFLRWDRQK CRAKPQGQWA EDVLGNKTWD RETGHLTENG KDLRMTLAHI KDQKGGLHSL QEIKVCEIHE DSSTRSSRHF YYDGELFLSQ NLETQELTVP QSSRAHTLAM NVTNFWKEAA MKTKTHYRAL QANCRQKLQQ YLESGVVLRR TVPPMVNVTH GKASEGNITV TCWASGFYPW NITLTWRQDG VSLSHDTQQW EGVLPDRNGT YQTWVATRIR QGEEQRFTCY MEHSGNQSTH PVPS // ID H2PIH3_PONAB Unreviewed; 360 AA. AC H2PIH3; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000018370}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000018370, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000018370, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000018370} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01191071; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2PIH3; -. DR STRING; 9601.ENSPPYP00000018370; -. DR Ensembl; ENSPPYT00000019104; ENSPPYP00000018370; ENSPPYG00000016428. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2PIH3; -. DR OMA; LVLQSHW; -. DR OrthoDB; EOG091G0ANY; -. DR TreeFam; TF342166; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 286 307 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 183 272 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 360 AA; 40424 MW; C522D5FD19A76C97 CRC64; PHSLRYNLTV LSQDGSVQSG FLAEVHLDGQ PFLRWDRQKC RAKPQGQWAE DVLGNKTWDR ETGHLTENGK DLRMTLAHIK DQKGGLHSLQ EIKVCEIHED SSTRSSRHFY YDGELFLSQN LETQELTVPQ SSRAHTLAMN VTNFWKEAAM KTKTHYRALQ ANCRQKLQQY LESGVVLRRT VPPMVNVTHG KASEGNITVT CWASGFYPWN ITLTWRQDGV SLSHDTQQWE GVLPDRNGTY QTWVATRIRQ GEEQRFTCYM EHSGNQSTHP VPSGKVLVLQ SHWQTFHVSA VAAAAAIFVI IIFYALLCKK KTSAAEGPEL VSLQALDQHP VGTGDHRDDA QLGFQPLMSV LGSTGSTEGA // ID H2PIH4_PONAB Unreviewed; 383 AA. AC H2PIH4; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 18-JUL-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000018371}; GN Name=MICB {ECO:0000313|Ensembl:ENSPPYP00000018371}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000018371, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000018371, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000018371} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01191060; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01191061; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_002816758.1; XM_002816712.3. DR ProteinModelPortal; H2PIH4; -. DR STRING; 9601.ENSPPYP00000018371; -. DR Ensembl; ENSPPYT00000019106; ENSPPYP00000018371; ENSPPYG00000016430. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2PIH4; -. DR OMA; CVPCCKK; -. DR OrthoDB; EOG091G0ANY; -. DR TreeFam; TF342166; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 383 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003568968. FT DOMAIN 207 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 383 AA; 42810 MW; BF3AEB5ACDCE7100 CRC64; MGLGPVLLFL AGIFPFAPPG AAAEPHSLRY NLTVLSQDGS VQSEFLAEGH LDGQPFLHYD RQKHRAKPLG QWAENVLGAK TWDTETEDLT ENGRDLRRTL THIKDQKGGL HSLQEIKVCE IHEDRSTRGS WHFYYDGELF LSQNLETQEW TVPQSSRAQT LAINIMNFWK EDAMKTKTHY RAVQADCLQK LQRYLESGIV LRRIVPPMVN VTCSEASAGN ITMTCRASSF YPWNITLTWR QDGISLSHDA QQWGDVLPDR NGTYQTWVAT RIRQGEEQRF TCYMEHSGNH GTHPVPSGKA LVLQSQWTDF PYVSAAMPCF VIIIILCVPC CKKKISVAEG PELVSLQALD QHPVGTGDHR DAAQLGFQTL MSAPGSTGST EGA // ID H2PKL5_PONAB Unreviewed; 263 AA. AC H2PKL5; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Retinoic acid early transcript 1E {ECO:0000313|Ensembl:ENSPPYP00000019143}; GN Name=RAET1E {ECO:0000313|Ensembl:ENSPPYP00000019143}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000019143, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000019143, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000019143} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01220267; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9601.ENSPPYP00000019143; -. DR Ensembl; ENSPPYT00000019898; ENSPPYP00000019143; ENSPPYG00000017097. DR eggNOG; ENOG410JBPA; Eukaryota. DR eggNOG; ENOG411150N; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; H2PKL5; -. DR OMA; WQFAING; -. DR OrthoDB; EOG091G0NI5; -. DR TreeFam; TF339658; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IEA:Ensembl. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 30 {ECO:0000256|SAM:SignalP}. FT CHAIN 31 263 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003568008. FT TRANSMEM 227 247 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 30 197 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 263 AA; 29973 MW; ADA1E006C41FA9E8 CRC64; MRRISLTSSP VHLLLLLLLL LIALEIMVGA HSLCFNFTIK SLSRPGQPWC EAQVFLNKNL FLQYNSDNNM VKPLGLLGKK VNATSTWGEL TQMLGEVGRD LRMLLLDIKP QIKTSGPSTL QVEMFCQREA EQCTGASWQF AINGEKSLLF DAMNMTWTVI NHEASKIKET WKKDRGLEKY FRKLSKGDCD HWLREFLGHW EAMPEPTVSP VNASDTHWPS SSLPDTWIIL GAFILLVLMG IVLIYVWRQN GEWQAGLWPL RTS // ID H2PKL6_PONAB Unreviewed; 252 AA. AC H2PKL6; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 22. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000019144}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000019144, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000019144, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000019144} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01220269; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01220270; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9601.ENSPPYP00000019144; -. DR Ensembl; ENSPPYT00000019899; ENSPPYP00000019144; ENSPPYG00000017098. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; H2PKL6; -. DR OMA; QIAKRPL; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001595; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 252 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003568705. FT DOMAIN 31 198 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 252 AA; 27830 MW; F8927267C478A234 CRC64; MAAAASPAFL LRLPLLLLLS GWCRTGLADP HSLCYDITII PKFRPGPWWC AVRGQLDKKT FLQYDCGNKT VTPISPLGKK LNVTKAWKAQ NPVLREVVDM FTEQLLDIQL ENYTPREPLT LQARMSCEQK ANGHSGGSWQ FSFDGQVFLL FDSENRMWTT VHPGARKMKE RWENDKDVTM PFHYISMGDC TGWLEDFLVG MDSTLEPSAG APPAVSSGAA QPRATATPLI LCSSSSSSPA SSYLAAEESP LE // ID H2PKL7_PONAB Unreviewed; 243 AA. AC H2PKL7; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 25-APR-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000019145}; GN Name=ULBP2 {ECO:0000313|Ensembl:ENSPPYP00000019145}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000019145, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000019145, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000019145} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01220271; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_002817529.1; XM_002817483.2. DR ProteinModelPortal; H2PKL7; -. DR STRING; 9601.ENSPPYP00000019145; -. DR Ensembl; ENSPPYT00000019900; ENSPPYP00000019145; ENSPPYG00000017099. DR GeneID; 100433010; -. DR KEGG; pon:100433010; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; H2PKL7; -. DR KO; K07986; -. DR OMA; NISMGDC; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 243 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003569040. FT TRANSMEM 221 240 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 27 196 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 243 AA; 27292 MW; 9F8FBEC2FB31885E CRC64; MAAAAATKIL LCLPLLSRWS RAGRADPHSL CYNITIIPKF RPGPRWCAVQ GQLDKKTFLQ YDCGNKTVIP ISPLGKKLNV TKAWKAQNPV LREVVDMLTE QLFEIQLENY TPREPLTLQA RMSCEQKANG HSGGSWQFSF NGQVFLLFDS ENGMWTTVHP GARKMKERWE NDKDVTISFH NISMGDCKGW LEDFLMGMDR TLEPSARAPL TMSSGTTQLR AMATTLILCC LLIILPCFIL PGI // ID H2PKL8_PONAB Unreviewed; 244 AA. AC H2PKL8; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=UL16 binding protein 1 {ECO:0000313|Ensembl:ENSPPYP00000019146}; GN Name=ULBP1 {ECO:0000313|Ensembl:ENSPPYP00000019146}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000019146, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000019146, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000019146} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01220271; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01220272; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01220273; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_002817530.1; XM_002817484.3. DR STRING; 9601.ENSPPYP00000019146; -. DR Ensembl; ENSPPYT00000019901; ENSPPYP00000019146; ENSPPYG00000017100. DR GeneID; 100433399; -. DR KEGG; pon:100433399; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; H2PKL8; -. DR KO; K07986; -. DR OMA; CKMWLEE; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl. DR GO; GO:0046658; C:anchored component of plasma membrane; IEA:Ensembl. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IEA:Ensembl. DR GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 244 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003567401. FT TRANSMEM 222 242 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 40 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 244 AA; 28089 MW; 8E863B213ACE9AC9 CRC64; MAAAASPAFL LCLPLLHLLS GWSRAGRVDT HCLCYDFIIT PKSRPEPQRC EVQGLVDERL FLHYDCVNHK AKAFASLGKK VNVTKTWEEQ TETLRDVVDF LKGQLLDIQV ENLIPIEPLI LQARMSCEHE AHGLSRGSWQ FLFNGQKFLL FDSNNRKWTA LHPRAKKMKE KWEKNRDVTM FFQKISMGDC KMWLEEFLMY WEQMLDPTKP PSLAPGTTQA KAMATTLSPW SLLIIFLCFI LAGR // ID H2PKL9_PONAB Unreviewed; 246 AA. AC H2PKL9; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000019147}; GN Name=LOC100434525 {ECO:0000313|Ensembl:ENSPPYP00000019147}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000019147, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000019147, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000019147} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01220283; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_002817531.1; XM_002817485.1. DR ProteinModelPortal; H2PKL9; -. DR STRING; 9601.ENSPPYP00000019147; -. DR Ensembl; ENSPPYT00000019902; ENSPPYP00000019147; ENSPPYG00000017101. DR GeneID; 100434525; -. DR KEGG; pon:100434525; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; H2PKL9; -. DR KO; K07987; -. DR OMA; FLVHWEE; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 246 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003569032. FT TRANSMEM 224 244 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 30 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 246 AA; 27556 MW; 8940B4C3952DD0A0 CRC64; MAAAAIPALL LCLPLLFLLF GWTRAGRDDP HSLCYDITII PKLRPGPRWC AVQGQVDKST FLHNDCGNKT VTPISPLGKK LNVAKAWKEQ NLVLREVVDM PTEQPLDIQL ENYTPREPLT LQARVSCEQK AKGHSSGSWQ FSFDGQIFLL FDSENRMWTT VHPGARKMKE KWEDNKDVTM SFHYISMGDC TEWLEDFLMG MDRTLEPSAG APITISSGTT QLRAMATTLI LCCLLIILPC FILAGI // ID H2PL04_PONAB Unreviewed; 362 AA. AC H2PL04; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 28-MAR-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000019282}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000019282, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000019282, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000019282} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01291091; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2PL04; -. DR Ensembl; ENSPPYT00000020041; ENSPPYP00000019282; ENSPPYG00000017213. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H2PL04; -. DR OMA; HYLEEEC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003568711. FT TRANSMEM 308 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 282 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 41042 MW; 7895A1BAB86BBB22 CRC64; MAPRTLLLLL SEVLALTETW AGSHSMRYFD TSVSRPGRGE PRFITVGYVD DTQFVRFDSD AASPRMEPRV PCIEQEGPEY WDQETQKAKA SAQTDRVSLR TLLRYYNQSE DGSHTWQRMY GCYVGPDGRL LRGYDQYAYD GKDYIALNED LSSWTAADTA AQITQRKWEA ARWAEQLRAY LEGRCVQWLR RYLENGKETL QRADPPKTHV THHPNSDHET TLRCWALGFY PAEITLTWQR DGEDQTQDTE LVETRPADGT FQWAAVVVPS GEEQRYTCHV QHEGLPDPSP EWIRRGMREP SSQSTIPIVG IVAGLAVLAV VVIGIVVPAV MCRRKSSGRE GVRGGVWVFL STRVSAPVEV FP // ID H2PL08_PONAB Unreviewed; 323 AA. AC H2PL08; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 23-MAY-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000019286}; GN Name=DKFZP469I0912 {ECO:0000313|Ensembl:ENSPPYP00000019286}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000019286, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000019286, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000019286} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01164062; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01164063; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01164064; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_009231327.1; XM_009233052.1. DR ProteinModelPortal; H2PL08; -. DR Ensembl; ENSPPYT00000020045; ENSPPYP00000019286; ENSPPYG00000017214. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H2PL08; -. DR OMA; MKNATQT; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 323 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003569059. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 323 AA; 36375 MW; 50C5C64674CDC418 CRC64; MRAMAPRTLL LLLSGALAPT ETWAGSHSMR YFSTAVSRPG RGEPRFIAVG YVDDTQFVRF DSDAVSPRVE PLVPLIEQEG PEYWDQETQK AKTQAQNDRV SLRNLRGYYN QSEDGSHTWQ RMYGCDVGPD GRLLRGYCQF AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQL RAYLEGLCVE SLRRYLENGK ETLQRADCPK THVTHHPVSE HETILRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWGE KGGSYSQAAC SDTTQGSDVS LTA // ID H2PL35_PONAB Unreviewed; 365 AA. AC H2PL35; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 25-APR-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000019313}; GN Name=LOC100459440 {ECO:0000313|Ensembl:ENSPPYP00000019313}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000019313, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000019313, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000019313} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01360635; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01360636; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01364504; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01405315; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01405316; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01405317; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01405318; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01405319; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_009237821.1; XM_009239546.1. DR ProteinModelPortal; H2PL35; -. DR STRING; 9601.ENSPPYP00000019313; -. DR Ensembl; ENSPPYT00000020072; ENSPPYP00000019313; ENSPPYG00000017232. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003569068. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 40862 MW; 30EEBEDBEA203A26 CRC64; MVVMAPRTLL LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAVG YVDDTQFVRF DSDSASPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRL NLQILRGYYN QSEAGSHTIQ RMYGCEVGSH GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DIAAQIIKRK WEAAGVGEQE RAYLEGTCVE WLRRHLKNGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWVA VVVPSGKEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLVLLGA VITGAVVAAV MWRRRSSDRK GGSYSQAASN DSAQGSDVSL TACKV // ID H2PL65_PONAB Unreviewed; 362 AA. AC H2PL65; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 20-JUN-2018, entry version 49. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000019343}; GN Name=LOC100438533 {ECO:0000313|Ensembl:ENSPPYP00000019343}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000019343}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000019343} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000019343} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01352973; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_003775429.2; XM_003775381.2. DR STRING; 9601.ENSPPYP00000019343; -. DR Ensembl; ENSPPYT00000020102; ENSPPYP00000019343; ENSPPYG00000017252. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H2PL65; -. DR OMA; TESWIAP; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003569074. FT TRANSMEM 306 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40678 MW; A89F1190AD9DE2A0 CRC64; MRIMAPRTLL LLLSAALAPT ETWAGSHSMK YFYTGMSRPG RGEPRFISVG YVDDTQFVWF DSDAVSPREE PRAPWIEQEG PEYWDRNTQI YKANTQTYRE SLRNLRGYYN QSEDGSHTWQ SMYGCDVGPD GRLLRGYDQF AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAGWAEQF RAYLEGRCVE SLRRYLENGK ETLQRAEPPR THMTHHPISD HETTLRCWAL GFYPAEITLT WQRDREDLTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGIVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA // ID H2PL71_PONAB Unreviewed; 259 AA. AC H2PL71; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 28-MAR-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000019349}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000019349}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000019349} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000019349} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01156126; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2PL71; -. DR Ensembl; ENSPPYT00000020108; ENSPPYP00000019349; ENSPPYG00000017256. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H2PL71; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001595; Chromosome 6. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 259 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003567433. FT DOMAIN 208 259 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 259 AA; 29665 MW; 17A9F83A9A10CA45 CRC64; MVMAPRTLLL LLSGTMALAE TWAGSHSLRY FSTAVSQPGR GEPRFIAVGY VDDTQFVRFD SDAASPRMKT RSRWVEQEGP EYWDLQTLGA KAQAQTDRVN LRTLLRYYNQ SEAGYHILQG MFGCDLGPDG RLLRGYEQYA YDGKGYIALN EDLRSWTAAD TAAQITQRKW EVANVAEQRR AYLVSTCVEW LCRHLEKGKE TLQRADPPKT HVTHHPVSEH EATLRCWALG FYPAEITLTW QRDREDQIQD TEFXXXXXX // ID H2PL72_PONAB Unreviewed; 78 AA. AC H2PL72; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000019259}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000019259, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000019259, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000019259} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01089911; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPPYT00000020017; ENSPPYP00000019259; ENSPPYG00000017194. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H2PL72; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000001595; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}. FT DOMAIN 1 78 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 78 AA; 8908 MW; 37C57799BB2672E7 CRC64; GCDLGPDGRL LRGYEQYAYD GKGYIALNED LRSWTAADTA AQITQRKWEV ANVAEQRRAY LVSTCVEWLC RHLEKGKE // ID H2PL75_PONAB Unreviewed; 66 AA. AC H2PL75; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000019353}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000019353, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000019353, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000019353} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01174139; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9601.ENSPPYP00000019353; -. DR Ensembl; ENSPPYT00000020113; ENSPPYP00000019353; ENSPPYG00000017260. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H2PL75; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000001595; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}. FT DOMAIN 1 65 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 66 AA; 7623 MW; BC7F28C1DB5D3BF5 CRC64; AVSRPGRGEP RFIAVGYVDD TQFVRFDSDS ASPRMEPRAP WVEQEGPEYW EEETRNTKAH AQTDRL // ID H2PL81_PONAB Unreviewed; 211 AA. AC H2PL81; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000019360}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000019360, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000019360, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000019360} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01345580; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01345581; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9601.ENSPPYP00000019360; -. DR Ensembl; ENSPPYT00000020121; ENSPPYP00000019360; ENSPPYG00000017268. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; H2PL81; -. DR OMA; WGKQLEM; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000001595; Chromosome 6. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}. FT DOMAIN 2 173 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 62 82 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 211 AA; 24123 MW; 3D52A80DF0F67131 CRC64; AHSLWYNFTI IRLPRHGQQW CEVQSQVDQK NFLCYDCGSD KVLSMGHLEE QLSATDAWGK QLEMLRQVGQ RLRLELADTE LEDFTPSGPL LLRARMSCDC DPDGCFRVSC HFSFDGQKLL DSNRKWTVVH AGARQMKEKW EKDSGLTTFF KMVSMGDCKS WLRDFLMHRK KRLEPTAPPT VAPGLAQPKA IATTLSPWSF LIILCFILPG I // ID H2PLK8_PONAB Unreviewed; 341 AA. AC H2PLK8; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 23-MAY-2018, entry version 50. DE SubName: Full=Alpha-2-glycoprotein 1, zinc-binding {ECO:0000313|Ensembl:ENSPPYP00000019490}; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSPPYP00000019490}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000019490, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000019490, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000019490} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01096962; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2PLK8; -. DR Ensembl; ENSPPYT00000020260; ENSPPYP00000019490; ENSPPYG00000017393. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2PLK8; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001595; Chromosome 7. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT DOMAIN 250 335 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 341 AA; 38572 MW; 519B94CF32B07281 CRC64; MSCSAPPSSP LQHPSLAFPT HHLGSPGGQQ DPEAAAETAE ADTMVRMVSV LLSLLLLLGP AVPQETQDGR YSLTYIYTGL SKLVEDVPAF QALGSLNDLQ FFRYNSRDRK SQPVGLWRQV EGMEDWKQDS QLQKAREDIF METLKDIVEY YNASNGSHVL QGRFGCEIEN NRSSGAFWKY YYDGKDYIEF NKEIPAWVPF DPAAQNTKQK WEAEPVYVQR AKAYLEEECP ATLRKYLKYS KNILDRQDPP SVVVTSHQAP GEKKKLKCLA YDFYPGKIDV HWTRAGEVQE PELWGDVLHN GNGTYQSWVV VAVPPQDTAP YSCHVQHSSL AQPLVVPWEA R // ID H2PLS5_PONAB Unreviewed; 127 AA. AC H2PLS5; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 20-JUN-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000019558}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000019558, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000019558, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000019558} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01059871; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2PLS5; -. DR Ensembl; ENSPPYT00000020329; ENSPPYP00000019558; ENSPPYG00000017447. DR eggNOG; ENOG410IYF3; Eukaryota. DR eggNOG; ENOG4111980; LUCA. DR GeneTree; ENSGT00920000150613; -. DR InParanoid; H2PLS5; -. DR OMA; NDIIDYY; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000001595; Chromosome 7. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 127 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003569078. FT DOMAIN 26 116 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 127 AA; 14681 MW; B6A6DC54C0E44966 CRC64; MVRMVSVLLS LLLLLGPAVP QETQDGHYSL TYLYTGLSRP GKGTHRLLQG TVFLNDRAFF HYNSEDRKAE PLGPWRHVEG VEDWEKQSQV QRAREDIFIE TLNNIMEYYN DSNAPSCRTG CSQYWLN // ID H2PXR2_PONAB Unreviewed; 362 AA. AC H2PXR2; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000023556}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000023556, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000023556, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000023556} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABGA01271989; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9601.ENSPPYP00000023556; -. DR Ensembl; ENSPPYT00000029410; ENSPPYP00000023556; ENSPPYG00000025931. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H2PXR2; -. DR OMA; GYCQEAY; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001595; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003568362. FT TRANSMEM 306 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40450 MW; 4963EC540B14A0B6 CRC64; MAVMAPRTLL LLLSGAPALT QTWAGSHSMR YFSTSVSRPG RGEPRYLEVG YVDDTQFVRF DSDAASPRME LRASWVQQEG PEYWDRNTRR AKANAQTDRV DLGTLRGYYN QSEAGSHTIQ RMYGCEVGSH GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DIAAQIIKRK WEAAGVGEQE RAYLEGTCVE WLRRHLKNGK ETLQRTTPPK THMTHHPISD QEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWVA VVVPSGKEQR YTCHVQHEGL PEPLTLRWEL SSQPTIPIVV IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDVSL TA // ID A0A2J8NX10_PANTR Unreviewed; 346 AA. AC A0A2J8NX10; H2QSL7; DT 25-APR-2018, integrated into UniProtKB/TrEMBL. DT 25-APR-2018, sequence version 1. DT 12-SEP-2018, entry version 5. DE SubName: Full=HLA-F isoform 1 {ECO:0000313|EMBL:PNI76305.1}; DE SubName: Full=HLA-F isoform 3 {ECO:0000313|EMBL:PNI76307.1}; DE SubName: Full=Patr class I histocompatibility antigen, CH28 alpha chain precursor {ECO:0000313|Ensembl:ENSPTRP00000030544}; GN Name=PATR-F {ECO:0000313|Ensembl:ENSPTRP00000030544}; GN ORFNames=CK820_G0006688 {ECO:0000313|EMBL:PNI76305.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|EMBL:PNI76305.1}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000030544, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000030544} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|EMBL:PNI76305.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI76305.1}; RC TISSUE=Blood {ECO:0000313|EMBL:PNI76305.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., RA Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C., RA Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V., RA Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S., RA Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I., RA Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AACZ04022776; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; NBAG03000221; PNI76305.1; -; Genomic_DNA. DR EMBL; NBAG03000221; PNI76307.1; -; Genomic_DNA. DR RefSeq; XP_016810081.1; XM_016954592.1. DR Ensembl; ENSPTRT00000033063; ENSPTRP00000030544; ENSPTRG00000017910. DR GeneTree; ENSGT00760000118960; -. DR OMA; VTHHPVF; -. DR Proteomes; UP000002277; Chromosome 6. DR Bgee; ENSPTRG00000017910; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 346 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015082620. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 346 AA; 39051 MW; 41BAC1AEDB076E5C CRC64; MAPRSLLLLL SGALALTETW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WERTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL QRADPPKAHI AHHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPAGDG NFQKWAAVVV PSGEEQRYTC HVQHEGLPQP LTLRWEQSPQ PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAV // ID H2QSL8_PANTR Unreviewed; 356 AA. AC H2QSL8; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPTRP00000030551}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000030551, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000030551, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000030551} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC192848; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9598.ENSPTRP00000030551; -. DR PaxDb; H2QSL8; -. DR Ensembl; ENSPTRT00000033070; ENSPTRP00000030551; ENSPTRG00000017906. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H2QSL8; -. DR OMA; QPRFIAV; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002277; Chromosome 6. DR Bgee; ENSPTRG00000017906; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 356 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014147984. FT TRANSMEM 307 331 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 356 AA; 40449 MW; 5A12B2F68477AF0E CRC64; MVLMAPRTLL LLLSGTLALT QTWARSHSMR YFYTTMSRPG RGEPRFISVG YVDDTQFVRF DSDDASPREE PRAPWMEREG PEYWDRNTQI CKAQAQTERE NLRMALRYYN QSEGSHTMQV MYGCDVGPDG RFLRGYEQHA YDGKDYIALN EDLSSWTAAD MAAQITKRKW EAARRPEQLR AYLEGEFVEW LRRYLENGKE TLQRADPPKT HMTHHPISDH EATLRCWALG FYPAEITLTW QRDGEDQTQD TELVETRPAG DGTFQKWAAV VVPSGEEQRY TCHVQHEGLP EPLTLRWEPS SQPTVPIVGI VAGLVLLVAV VTGAVVAAVM WRKKSSGKEG VRSSNSAQGS DVSLMA // ID H2QV12_PANTR Unreviewed; 298 AA. AC H2QV12; A0A2J8Q0G5; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 12-SEP-2018, entry version 49. DE SubName: Full=AZGP1 isoform 2 {ECO:0000313|EMBL:PNI89762.1}; DE SubName: Full=Alpha-2-glycoprotein 1, zinc-binding {ECO:0000313|Ensembl:ENSPTRP00000033312}; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSPTRP00000033312, GN ECO:0000313|VGNC:VGNC:14071}; GN ORFNames=CK820_G0047479 {ECO:0000313|EMBL:PNI89762.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000033312, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000033312, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000033312} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|EMBL:PNI89762.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI89762.1}; RC TISSUE=Blood {ECO:0000313|EMBL:PNI89762.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., RA Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C., RA Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V., RA Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S., RA Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I., RA Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC192162; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; NBAG03000093; PNI89762.1; -; Genomic_DNA. DR RefSeq; XP_001143820.1; XM_001143820.5. DR PaxDb; H2QV12; -. DR Ensembl; ENSPTRT00000036038; ENSPTRP00000033312; ENSPTRG00000019465. DR GeneID; 737709; -. DR KEGG; ptr:737709; -. DR CTD; 563; -. DR VGNC; VGNC:14071; AZGP1. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2QV12; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002277; Chromosome 7. DR Bgee; ENSPTRG00000019465; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 298 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015093111. FT DOMAIN 207 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 298 AA; 34328 MW; 01DA153A8E32A0B1 CRC64; MVRMVPVLLS LLLLLGPAVP QENQDGRYSL TYIYTGLSKH VEDVPAFQAL GSLNDLQFFR YNSKDRKSQP MGLWRQVEGM EDWKQDSQLQ KAREDIFMET LKDIVEYYND SNGSHVLQGR FGCEIENNRS SGAFWKYYYD GKDYIEFNKE IPAWVPFDPA AQITKQKWEA EPVYVQRAKA YLEEECPATL RKYLKYSKNI LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT RAGEVQEPEL RGDVLHNGNG TYQSWVVVAV PPQDTAPYSC HVQHSSLAQP LVVPWEAR // ID H2QZS0_PANTR Unreviewed; 263 AA. AC H2QZS0; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 36. DE SubName: Full=Retinoic acid early transcript 1E {ECO:0000313|Ensembl:ENSPTRP00000039447}; GN Name=RAET1E {ECO:0000313|Ensembl:ENSPTRP00000039447, GN ECO:0000313|VGNC:VGNC:3679}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000039447, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000039447, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000039447} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AACZ04054481; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_016811952.1; XM_016956463.1. DR STRING; 9598.ENSPTRP00000039447; -. DR PaxDb; H2QZS0; -. DR Ensembl; ENSPTRT00000050584; ENSPTRP00000039447; ENSPTRG00000022565. DR GeneID; 463064; -. DR KEGG; ptr:463064; -. DR CTD; 135250; -. DR VGNC; VGNC:3679; RAET1E. DR eggNOG; ENOG410JBPA; Eukaryota. DR eggNOG; ENOG411150N; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; H2QZS0; -. DR KO; K07987; -. DR OMA; WQFAING; -. DR OrthoDB; EOG091G0NI5; -. DR TreeFam; TF339658; -. DR Proteomes; UP000002277; Chromosome 6. DR Bgee; ENSPTRG00000022565; Expressed in 4 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 263 AA; 30128 MW; 0AF1564077AD325E CRC64; MRRISLTSRP VRLLLLLLLL LIALEIMVGG HSLCFNFTIK LLSRPGQPWC EAQVFLNKNI FLQYNSDNNM VKPLGLLGKK VNATSTWGEL TQMLGEVGRD LRMLLLDIKP QIKTSGPSTL QVEMFCQREA ERCTGASWQF AINGEKSLLF DAMNMTWTVI NHEASKIKET WKKDRGLEKY FRKLSKGDCD HWLREFLGHW EAMPEPTVSP VNASDIHWSS SSLPDRWIIL GAFILLVLMG IVLICVWWQN GEWQAGLWPL RTS // ID H2QZY1_PANTR Unreviewed; 243 AA. AC H2QZY1; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 12-SEP-2018, entry version 39. DE SubName: Full=UL16 binding protein 1 {ECO:0000313|EMBL:JAA31596.1, ECO:0000313|Ensembl:ENSPTRP00000083167}; GN Name=ULBP1 {ECO:0000313|EMBL:JAA31596.1, GN ECO:0000313|Ensembl:ENSPTRP00000083167}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000083167, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000083167, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|EMBL:JAA31596.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Skin {ECO:0000313|EMBL:JAA31596.1}; RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.; RT "De novo assembly of the reference chimpanzee transcriptome from RT NextGen mRNA sequences."; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPTRP00000083167} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2018) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AACZ04054483; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; GABD01001504; JAA31596.1; -; mRNA. DR EMBL; GABD01001502; JAA31598.1; -; mRNA. DR EMBL; GABD01001501; JAA31599.1; -; mRNA. DR EMBL; GABD01001500; JAA31600.1; -; mRNA. DR EMBL; GABD01001499; JAA31601.1; -; mRNA. DR RefSeq; XP_001134754.1; XM_001134754.5. DR STRING; 9598.ENSPTRP00000039774; -. DR Ensembl; ENSPTRT00000092451; ENSPTRP00000083167; ENSPTRG00000043696. DR GeneID; 735443; -. DR KEGG; ptr:735443; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR KO; K07986; -. DR OMA; CKMWLEE; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000002277; Chromosome 6. DR Bgee; ENSPTRG00000023594; Expressed in 5 organ(s), highest expression level in cerebellum. DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl. DR GO; GO:0046658; C:anchored component of plasma membrane; IEA:Ensembl. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 243 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014093294. FT TRANSMEM 221 241 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 39 202 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 243 AA; 27839 MW; DB68F8BE4978BA31 CRC64; MAAAASPAFL LCLPLLHLLS GWSRAGWVDT HCLCYDFIIT PKSRPEPQWC EVQGLVDEMP FLHYDCVNHK AKAFAPLGKK VNVTKTWEEQ TETLRDVVDF LKGQLLDIQV ENLIPIEPLT LQARMSCEHE AHGHGRGSWQ FLFNGQKFLL FDSNNRKWTA LHPGANKMTE KWENRDVTMF FQKISLGDCK MWLEEFLMYW EQMLDPTKPP SLAPGTTQPK AMATTLSPWS LLIIFLCFIL AGR // ID H2R0L5_PANTR Unreviewed; 246 AA. AC H2R0L5; A0A2J8PRZ5; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 35. DE SubName: Full=ULBP2 isoform 1 {ECO:0000313|EMBL:PNI86778.1}; GN Name=LOC463066 {ECO:0000313|Ensembl:ENSPTRP00000040901}; GN ORFNames=CK820_G0000001 {ECO:0000313|EMBL:PNI86778.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000040901, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000040901, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000040901} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|EMBL:PNI86778.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI86778.1}; RC TISSUE=Blood {ECO:0000313|EMBL:PNI86778.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., RA Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C., RA Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V., RA Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S., RA Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I., RA Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AACZ04054481; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; NBAG03000210; PNI86778.1; -; Genomic_DNA. DR RefSeq; XP_009450502.2; XM_009452227.2. DR RefSeq; XP_518801.3; XM_518801.6. DR STRING; 9598.ENSPTRP00000040901; -. DR PaxDb; H2R0L5; -. DR Ensembl; ENSPTRT00000045084; ENSPTRP00000040901; ENSPTRG00000052558. DR GeneID; 463066; -. DR KEGG; ptr:463066; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; H2R0L5; -. DR KO; K07986; -. DR OMA; FLVHWEE; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000002277; Chromosome 6. DR Bgee; ENSPTRG00000033979; Expressed in 3 organ(s), highest expression level in cerebellum. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 246 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014576335. FT TRANSMEM 224 243 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 46 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 246 AA; 27445 MW; 5E52E90BF65E9219 CRC64; MAAAAATKIL LCLPLLLLLS GWSRAGRADP HSLCCDITII PKFRPGPRWC AVQGQVDKKT FLHYDCGNKT VTPVSPLGNK LNVTKAWKAQ NPVLREVVDI LTEQLLDIQL ENYIPEEPLT LQARMSCEQK AEGHSSGSWQ FSFDGQIFLL FDSEKRMWTT VHPGARKMKE KWENDKDMTM SFHYISMGDC TRWLEDFLMG MDSTLEPSAG APLAMPSGTT QLRATATTLI LCCLLIILPC FILPGI // ID H2R0S1_PANTR Unreviewed; 339 AA. AC H2R0S1; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 39. DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSPTRP00000041152}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSPTRP00000041152, GN ECO:0000313|VGNC:VGNC:7558}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000041152, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000041152, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000041152} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AACZ04055860; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9598.ENSPTRP00000041152; -. DR PaxDb; H2R0S1; -. DR Ensembl; ENSPTRT00000042861; ENSPTRP00000041152; ENSPTRG00000023168. DR VGNC; VGNC:7558; FCGRT. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2R0S1; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002277; Chromosome 19. DR Bgee; ENSPTRG00000023168; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; IBA:GO_Central. DR GO; GO:0019770; F:IgG receptor activity; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 272 295 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 176 263 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 339 AA; 37041 MW; 1BE6634B7CC13AD7 CRC64; HLSLLYHLTA VSSPAPGTPA FWVSGWLGPQ QYLSYNSLRG EAEPCGAWVW ENQVSWYWEK ETTDLRIKEK LFLEAFKALG GKGPYTLQGL LGCELGPDNT SVPTAKFALN GEEFMNFDLK QGTWGGDWPE ALAISQRWQQ QDKAANKELT FLLFSCPHRL REHLERGRGN LEWKEPPSMR LKARPSSPGF SVLTCSAFSF YPPELQLRFL RNGLAAGTGQ GDFGPNSDGS FHASSSLTVK SGDEHHYCCI VQHAGLAQPL RVELESPAKS SVLVVGIVIG VLLLTAAAVG GALLWRRMRS GLPAPWISLR GDDTGVLLPT PGEAQDADLK DVNVIPATA // ID H2R125_PANTR Unreviewed; 353 AA. AC H2R125; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 43. DE SubName: Full=Patr class I histocompatibility antigen, CH28 alpha chain precursor {ECO:0000313|Ensembl:ENSPTRP00000041683}; GN Name=PATR-F {ECO:0000313|Ensembl:ENSPTRP00000041683}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000041683, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000041683, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000041683} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AACZ04022776; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_016810080.1; XM_016954591.1. DR Ensembl; ENSPTRT00000045537; ENSPTRP00000041683; ENSPTRG00000017910. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000002277; Chromosome 6. DR Bgee; ENSPTRG00000017910; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 353 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014185588. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 353 AA; 39808 MW; 793FFB5B4774CF4B CRC64; MAPRSLLLLL SGALALTETW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WERTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL QRADPPKAHI AHHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPAGDG NFQKWAAVVV PSGEEQRYTC HVQHEGLPQP LTLRWEQSPQ PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAGKMKE ADP // ID H2R127_PANTR Unreviewed; 246 AA. AC H2R127; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPTRP00000041687}; GN Name=LOC463159 {ECO:0000313|Ensembl:ENSPTRP00000041687}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000041687, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000041687, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000041687} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AACZ04040566; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_009450503.1; XM_009452228.2. DR STRING; 9598.ENSPTRP00000041687; -. DR PaxDb; H2R127; -. DR Ensembl; ENSPTRT00000046343; ENSPTRP00000041687; ENSPTRG00000044735. DR GeneID; 463159; -. DR KEGG; ptr:463159; -. DR CTD; 154064; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; H2R127; -. DR KO; K07987; -. DR OMA; NISMGDC; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000002277; Chromosome 6. DR Bgee; ENSPTRG00000034064; Expressed in 3 organ(s), highest expression level in cerebellum. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 246 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014156356. FT TRANSMEM 224 244 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 31 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 246 AA; 27538 MW; 804E1699C0120CC1 CRC64; MAAAAIPALL LCLPLLFLLF GWSRAGQDHP HSLCYDITVI PKFRPGPWWC AVQDQVDKKT FLHYDCGNKT VTPVSPLGNK LNVTKAWKAQ NPVLREVVDI LTEQLLDIQL ENYTPKEPLT LQARMSCEQK AEGHSSGSWQ FSFDGQIFLL FDSEKRMWTM VHPGARKMKE KWENDKVVAM SFHYISMGDC TGWLEDFLMG MDSTLEPSAG APLAMSSGTT QLRATATTLI LCCLLIILPC FILLGI // ID A0A2J8N6P1_PANTR Unreviewed; 249 AA. AC A0A2J8N6P1; H2R2K7; DT 25-APR-2018, integrated into UniProtKB/TrEMBL. DT 25-APR-2018, sequence version 1. DT 12-SEP-2018, entry version 3. DE SubName: Full=MR1 isoform 1 {ECO:0000313|EMBL:PNI67434.1}; DE SubName: Full=MR1 isoform 5 {ECO:0000313|EMBL:PNI67438.1}; DE SubName: Full=Major histocompatibility complex class I-related gene protein {ECO:0000313|Ensembl:ENSPTRP00000044099}; DE Flags: Fragment; GN Name=MR1 {ECO:0000313|Ensembl:ENSPTRP00000044099}; GN ORFNames=CK820_G0013608 {ECO:0000313|EMBL:PNI67434.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|EMBL:PNI67434.1}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000044099, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000044099} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|EMBL:PNI67434.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI67434.1}; RC TISSUE=Blood {ECO:0000313|EMBL:PNI67434.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., RA Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C., RA Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V., RA Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S., RA Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I., RA Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AACZ04056183; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; NBAG03000235; PNI67434.1; -; Genomic_DNA. DR EMBL; NBAG03000235; PNI67438.1; -; Genomic_DNA. DR Ensembl; ENSPTRT00000045675; ENSPTRP00000044099; ENSPTRG00000001746. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000002277; Chromosome 1. DR Bgee; ENSPTRG00000001746; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 249 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014559869. FT TRANSMEM 208 231 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 24 198 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:PNI67434.1}. SQ SEQUENCE 249 AA; 28941 MW; D865E979673D6A8A CRC64; VGELMAFLLP LIIVLMVKHS DSRTHSLRYF RLGVSDPIHG VPEFISVGYV DSHPITTYDS VTRQKEPRAP WMAENLAPDH WERYTQLLRG WQQMFKVELK RLQRHYNHSG SHTYQRMIGC ELLEDGSTTG FLQYAYDGQD FLIFNKDTLS WLAVDNVAHT IKQAWEANQH ELLYQKNWLE EECIAWLKRF LEYGKDTLQR TESETIPLVM KAVSGSIVLV IVLAGVGVLV WRRRPREQNG AIYLPTPDR // ID H2R6W1_PANTR Unreviewed; 244 AA. AC H2R6W1; A0A2J8QA13; K7DGX1; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 28. DE SubName: Full=UL16 binding protein 3 {ECO:0000313|EMBL:JAA38480.1, ECO:0000313|Ensembl:ENSPTRP00000049539}; DE SubName: Full=ULBP3 isoform 1 {ECO:0000313|EMBL:PNI93115.1}; DE SubName: Full=ULBP3 isoform 2 {ECO:0000313|EMBL:PNI93116.1}; GN Name=ULBP3 {ECO:0000313|EMBL:JAA38480.1, GN ECO:0000313|Ensembl:ENSPTRP00000049539, ECO:0000313|VGNC:VGNC:3781}; GN ORFNames=CK820_G0037918 {ECO:0000313|EMBL:PNI93115.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000049539, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000049539, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000049539} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|EMBL:JAA38480.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA38480.1}; RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.; RT "De novo assembly of the reference chimpanzee transcriptome from RT NextGen mRNA sequences."; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:PNI93115.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI93115.1}; RC TISSUE=Blood {ECO:0000313|EMBL:PNI93115.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., RA Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C., RA Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V., RA Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S., RA Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I., RA Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AACZ04040565; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; GABE01006259; JAA38480.1; -; mRNA. DR EMBL; NBAG03000056; PNI93115.1; -; Genomic_DNA. DR EMBL; NBAG03000056; PNI93116.1; -; Genomic_DNA. DR RefSeq; XP_009450504.2; XM_009452229.2. DR RefSeq; XP_016811957.1; XM_016956468.1. DR STRING; 9598.ENSPTRP00000049539; -. DR PaxDb; H2R6W1; -. DR Ensembl; ENSPTRT00000034531; ENSPTRP00000049539; ENSPTRG00000034286. DR GeneID; 472155; -. DR KEGG; ptr:472155; -. DR CTD; 79465; -. DR VGNC; VGNC:3781; ULBP3. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; H2R6W1; -. DR KO; K07986; -. DR OMA; WGKQLEM; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000002277; Chromosome 6. DR Bgee; ENSPTRG00000034286; Expressed in 6 organ(s), highest expression level in testis. DR GO; GO:0046658; C:anchored component of plasma membrane; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}. FT DOMAIN 31 206 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 92 112 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 244 AA; 27786 MW; 7DAEA14B460AFF35 CRC64; MAAAASPAIL PRLAILPYLL FDWSETGRAD THSLWYNFTI IHLPRHGQQW CEVQSQVDQK NFLSYDCGSD KVLSMGHLEE QLDATDAWGK QLEMLREVGQ RLRLELADTE LEDFTPSGPL TLQARMSCEC EADGCIRGSW QFSFDGQKFL LFDSNNRKWT VVHAGARWMK EKWEKDSGLT TFFKMVSMGD CKSWLRDFLM HRKKRLEPTA PPTVAPGLAQ PKAIATTLSP WSFLIILCFI LPGI // ID K7DPA9_PANTR Unreviewed; 335 AA. AC K7DPA9; A0A2J8PRY3; H2R6W2; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 12-SEP-2018, entry version 27. DE SubName: Full=RAET1G isoform 2 {ECO:0000313|EMBL:PNI86780.1}; DE SubName: Full=Retinoic acid early transcript 1G {ECO:0000313|EMBL:JAA42895.1, ECO:0000313|Ensembl:ENSPTRP00000049541}; GN Name=RAET1G {ECO:0000313|EMBL:JAA42895.1, GN ECO:0000313|Ensembl:ENSPTRP00000049541, ECO:0000313|VGNC:VGNC:52115}; GN ORFNames=CK820_G0000003 {ECO:0000313|EMBL:PNI86780.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA42895.1}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000049541, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000049541} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|EMBL:JAA42895.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA42895.1}, and RC Skin {ECO:0000313|EMBL:JAA31597.1}; RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.; RT "De novo assembly of the reference chimpanzee transcriptome from RT NextGen mRNA sequences."; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:PNI86780.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI86780.1}; RC TISSUE=Blood {ECO:0000313|EMBL:PNI86780.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., RA Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C., RA Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V., RA Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S., RA Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I., RA Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AACZ04054481; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; GABD01001503; JAA31597.1; -; mRNA. DR EMBL; GABE01001844; JAA42895.1; -; mRNA. DR EMBL; NBAG03000210; PNI86780.1; -; Genomic_DNA. DR RefSeq; XP_518800.3; XM_518800.6. DR STRING; 9598.ENSPTRP00000049541; -. DR Ensembl; ENSPTRT00000056754; ENSPTRP00000049541; ENSPTRG00000029377. DR GeneID; 463065; -. DR KEGG; ptr:463065; -. DR CTD; 353091; -. DR VGNC; VGNC:52115; RAET1G. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR KO; K07987; -. DR OMA; QIAKRPL; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000002277; Chromosome 6. DR Bgee; ENSPTRG00000029377; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IEA:Ensembl. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:0002729; P:positive regulation of natural killer cell cytokine production; IEA:Ensembl. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 335 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015095974. FT DOMAIN 30 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 335 335 {ECO:0000313|EMBL:PNI86780.1}. SQ SEQUENCE 335 AA; 37580 MW; 389363D1964F3847 CRC64; MAAAASPAFL LRLPLLLLLS SWCRTGLADP HSLCYDITVI PKFRPGPRWC AVQGQVDKKT FLRYDCGNKR VIPISHLGKK LNVTKAWKAQ NPVLREVVDM LTEQLLGIQL ENYIPREPLT LQARMSCEQK AEGHSSGSWQ FSFDGQIFLL FDSEKRMWTT VHPGARKMKE KWENDKDMTM SFHYISMGDC TGWLEDFLMG MDSTLEPSAG APPTMSSGTA QPRATATTLI LCCLLIMCLL MCPRHSLTQS HGHHPQSLQP PPHPPLLHPT WLLRRVLWSD SYQIAKRPLS GGHVTRVTLP IIGDDSHSLP CPLALYTINN GAARYSEPLQ VSISW // ID H2R7H5_PANTR Unreviewed; 383 AA. AC H2R7H5; A0A2J8NXM7; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 12-SEP-2018, entry version 51. DE SubName: Full=MHC class I polypeptide-related sequence B precursor {ECO:0000313|Ensembl:ENSPTRP00000050400}; DE SubName: Full=MICB isoform 3 {ECO:0000313|EMBL:PNI76518.1}; GN Name=MICB {ECO:0000313|EMBL:JAA06059.1, GN ECO:0000313|Ensembl:ENSPTRP00000050400}; GN ORFNames=CK820_G0006828 {ECO:0000313|EMBL:PNI76518.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000050400, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000050400, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000050400} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|EMBL:JAA06059.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA06059.1}, RC Skeletal muscle {ECO:0000313|EMBL:JAA44007.1}, RC Skin {ECO:0000313|EMBL:JAA23339.1}, and RC Smooth vascular {ECO:0000313|EMBL:JAA16146.1}; RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.; RT "De novo assembly of the reference chimpanzee transcriptome from RT NextGen mRNA sequences."; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:PNI76518.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI76518.1}; RC TISSUE=Blood {ECO:0000313|EMBL:PNI76518.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., RA Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C., RA Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V., RA Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S., RA Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I., RA Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AACZ04022799; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; GABC01005279; JAA06059.1; -; mRNA. DR EMBL; GABF01005999; JAA16146.1; -; mRNA. DR EMBL; GABD01009761; JAA23339.1; -; mRNA. DR EMBL; GABE01000732; JAA44007.1; -; mRNA. DR EMBL; GABE01000731; JAA44008.1; -; mRNA. DR EMBL; NBAG03000221; PNI76518.1; -; Genomic_DNA. DR UniGene; Ptr.6636; -. DR STRING; 9598.ENSPTRP00000050400; -. DR Ensembl; ENSPTRT00000033163; ENSPTRP00000050400; ENSPTRG00000017957. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; CVPCCKK; -. DR OrthoDB; EOG091G0ANY; -. DR TreeFam; TF342166; -. DR Proteomes; UP000002277; Chromosome 6. DR Bgee; ENSPTRG00000017957; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 383 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015093394. FT TRANSMEM 312 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 383 AA; 42660 MW; 2C0EDE6523E44D8F CRC64; MGLGPVLLFL AGIFHFAPPG AAAEPHSLRY NLTVLSRDGS VQSGFLAEVH LDGQPFLRCD RQKCRAKPQG QWAEDVLGNK TWDRETGDLT ENGKDLRMTL AHIKDQKGGL HSLQEIRVCE IHEDSSTRSS WHFYYDGELF LSQNLETQKW TAPQSSRAQT LAMNVTNFWK KEAMKTKTHY RAMQADCRQK LKRYLESGVV LRRTVPPMVN VTRSEASEGN ITVTCWASSF YPRNITLTWR QDGISLSHNA QQWGDVLPDG NGTYQTWVAT RICQGEEQRF TCYVEHSGNH GTHPVPSGKA LVLQSQRTEF PYVPVVMTCF VIIIILCVPC CKKKTSAAEG PELVSLQVLD QHPVGTGDHR DAAQLGFQPL MSAPGSTGST EGA // ID H2RAW5_PANTR Unreviewed; 343 AA. AC H2RAW5; A0A2J8NX27; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 41. DE SubName: Full=HLA-G isoform 1 {ECO:0000313|EMBL:PNI76312.1}; DE SubName: Full=Patr class I histocompatibility antigen, alpha chain G {ECO:0000313|Ensembl:ENSPTRP00000054628}; GN Name=PATR-G {ECO:0000313|Ensembl:ENSPTRP00000054628}; GN ORFNames=CK820_G0006703 {ECO:0000313|EMBL:PNI76312.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000054628, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000054628, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000054628} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|EMBL:PNI76312.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI76312.1}; RC TISSUE=Blood {ECO:0000313|EMBL:PNI76312.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., RA Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C., RA Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V., RA Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S., RA Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I., RA Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC192848; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; NBAG03000221; PNI76312.1; -; Genomic_DNA. DR Ensembl; ENSPTRT00000062077; ENSPTRP00000054628; ENSPTRG00000017908. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000002277; Chromosome 6. DR Bgee; ENSPTRG00000017910; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 343 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014576539. FT TRANSMEM 313 337 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 343 AA; 38822 MW; EF8F056ABB4F1B22 CRC64; MKTPRMVVMA PRTLFLLLSG ALTLTETWAG SHSMRYFSAA VSRPGRGEPR FIAMGYVDDT QFVWFDSDSA CPRMEPRAPW VEQEGPEYWE EETRNTKAHA QTDRINLQTL RGYYNQSEAS SHTLQWMIGC DLGSDGRLLR GYEQYAYDGK DYLALNEDLR SWTAADTAAQ ISKRKCEAAN AAEQRRAYLE GTCVEWLHRY LENGKEMLQR ADPPKTHVTH HPVFDYEATL RCWALGFYPA EIILTWQRDG EDQTQDVELV ETRPAGDGTF QKWAAVVVPS GEEQRYTCHV QHEGLPEPLM LRWKQSSLPT IPIMGIVAGL VVLAAVVTGA AVAAVLWRKK SSD // ID H2RAW6_PANTR Unreviewed; 442 AA. AC H2RAW6; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 42. DE SubName: Full=Patr class I histocompatibility antigen, CH28 alpha chain precursor {ECO:0000313|Ensembl:ENSPTRP00000054635}; GN Name=PATR-F {ECO:0000313|Ensembl:ENSPTRP00000054635}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000054635, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000054635, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000054635} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AACZ04022776; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_016810084.1; XM_016954595.1. DR UniGene; Ptr.6324; -. DR Ensembl; ENSPTRT00000062084; ENSPTRP00000054635; ENSPTRG00000017910. DR GeneID; 100169977; -. DR CTD; 100169977; -. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000002277; Chromosome 6. DR Bgee; ENSPTRG00000017910; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0009986; C:cell surface; IEA:Ensembl. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0046978; F:TAP1 binding; IEA:Ensembl. DR GO; GO:0046979; F:TAP2 binding; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 442 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014156360. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 350 372 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 392 412 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 442 AA; 50496 MW; 80EB3C2D44C66A28 CRC64; MAPRSLLLLL SGALALTETW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WERTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL QRADPPKAHI AHHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPAGDG NFQKWAAVVV PSGEEQRYTC HVQHEGLPQP LTLRWEQSPQ PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAAYSVV SRNLMIARWS SLFLLGVLFQ GYLGCLRSHS VLGRRKVGDM RILFFLWLWT SFNTAFLALQ SIRFGFGFRR GRSFLLRFWH HLMKRVQIKI FD // ID H2RB71_PANTR Unreviewed; 355 AA. AC H2RB71; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 45. DE SubName: Full=Patr class I histocompatibility antigen, alpha chain G {ECO:0000313|Ensembl:ENSPTRP00000055208}; GN Name=PATR-G {ECO:0000313|Ensembl:ENSPTRP00000055208}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000055208, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000055208, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000055208} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC192848; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2RB71; -. DR Ensembl; ENSPTRT00000062647; ENSPTRP00000055208; ENSPTRG00000017908. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H2RB71; -. DR OMA; FQRMIGC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002277; Chromosome 6. DR Bgee; ENSPTRG00000017908; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 33 {ECO:0000256|SAM:SignalP}. FT CHAIN 34 355 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014124443. FT TRANSMEM 317 341 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 218 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 355 AA; 39906 MW; 413F7738A45B8A87 CRC64; MDWGGPTPRM VVMAPRTLFL LLSGALTLTE TWAGSHSMRY FSAAVSRPGR GEPRFIAMGY VDDTQFVWFD SDSACPRMEP RAPWVEQEGP EYWEEETRNT KAHAQTDRIN LQTLRGYYNQ SEASSHTLQW MIGCDLGSDG RLLRGYEQYA YDGKDYLALN EDLRSWTAAD TAAQISKRKC EAANAAEQRR AYLEGTCVEW LHRYLENGKE MLQRADPPKT HVTHHPVFDY EATLRCWALG FYPAEIILTW QRDGEDQTQD VELVETRPAG DGTFQKWAAV VVPSGEEQRY TCHVQHEGLP EPLMLRWKQS SLPTIPIMGI VAGLVVLAAV VTGAAVAAVL WRKKSSGKEG VTSGV // ID H2RBW1_PANTR Unreviewed; 371 AA. AC H2RBW1; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 48. DE SubName: Full=Patr class I histocompatibility antigen, alpha chain G {ECO:0000313|Ensembl:ENSPTRP00000056399}; GN Name=PATR-G {ECO:0000313|Ensembl:ENSPTRP00000056399}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000056399, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000056399, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000056399} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC192848; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPTRT00000064838; ENSPTRP00000056399; ENSPTRG00000017908. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H2RBW1; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002277; Chromosome 6. DR Bgee; ENSPTRG00000017910; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0002767; P:immune response-inhibiting cell surface receptor signaling pathway; IEA:Ensembl. DR GO; GO:2001199; P:negative regulation of dendritic cell differentiation; IEA:Ensembl. DR GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl. DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl. DR GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; IEA:Ensembl. DR GO; GO:0002666; P:positive regulation of T cell tolerance induction; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 371 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014145172. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 371 AA; 41323 MW; 36CBD4956B29638E CRC64; MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG YVDDTQFVWF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRI NLQTLRGYYN QSEASSHTLQ WMIGCDLGSD GRLLRGYEQY AYDGKDYLAL NEDLRSWTAA DTAAQISKRK CEAANAAEQR RAYLEGTCVE WLHRYLENGK EMLQRADPPK THVTHHPVFD YEATLRCWAL GFYPAEIILT WQRDGEDQTQ DVELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLMLRWKQ SSLPTIPIMG IVAGLVVLAA VVTGAAVAAV LWRKKSSGKE GVTSSDSAQG SNVSLTACKC DTPGGPMCVG C // ID H2RBY9_PANTR Unreviewed; 337 AA. AC H2RBY9; A0A2J8JQD8; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=HFE isoform 13 {ECO:0000313|EMBL:PNI24995.1}; DE SubName: Full=Hereditary hemochromatosis protein homolog {ECO:0000313|Ensembl:ENSPTRP00000056517}; GN Name=HFE {ECO:0000313|Ensembl:ENSPTRP00000056517, GN ECO:0000313|VGNC:VGNC:2860}; GN ORFNames=CK820_G0045387 {ECO:0000313|EMBL:PNI24995.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000056517, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000056517, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000056517} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|EMBL:PNI24995.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI24995.1}; RC TISSUE=Blood {ECO:0000313|EMBL:PNI24995.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., RA Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C., RA Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V., RA Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S., RA Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I., RA Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AACZ04065844; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; NBAG03000433; PNI24995.1; -; Genomic_DNA. DR Ensembl; ENSPTRT00000064955; ENSPTRP00000056517; ENSPTRG00000017805. DR VGNC; VGNC:2860; HFE. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002277; Chromosome 6. DR Bgee; ENSPTRG00000017805; Expressed in 6 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 337 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015093461. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 337 AA; 38862 MW; 8F825D574C6C8048 CRC64; MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGASEQ DLGLSLFEAL GYVDDQLFVF YDHESRRVEP RTPWVSSRIS SQMWLQLSQS LKGWDHMFTV DFWTIMENHN HSKESHTLQV ILGCEMQEDN STEGYWKYGY DGQDHLEFCP DTLDWRAAEP RAWPTKLEWE RHKIRARQNR AYLERDCPAQ LQQLLELGRG VLDQQVPPLV KVTHHVTSSV TTLRCRALNY YPQNITMKWL KDKQPMDAKE FEPKDVLPNG DGTYQGWITL AVSPGEEQRY TCQVEHPGLD QPLIVIWEPS PSGTLVIGVI SGIAVFVVIL FIGILFIILR KRQGSSF // ID H2RDU4_PANTR Unreviewed; 165 AA. AC H2RDU4; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPTRP00000059356}; GN Name=LOC101056959 {ECO:0000313|Ensembl:ENSPTRP00000059356}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000059356, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000059356, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000059356} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AACZ04022776; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2RDU4; -. DR PaxDb; H2RDU4; -. DR Ensembl; ENSPTRT00000067768; ENSPTRP00000059356; ENSPTRG00000034414. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2RDU4; -. DR OMA; FWEENAM; -. DR OrthoDB; EOG091G0ANY; -. DR TreeFam; TF342166; -. DR Proteomes; UP000002277; Chromosome 6. DR Bgee; ENSPTRG00000034414; Expressed in 4 organ(s), highest expression level in liver. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 165 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014163279. FT DOMAIN 25 127 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 165 AA; 18534 MW; F2B8A5EA4B793FF5 CRC64; MEMSLVLLFL TRTALFAPQG AAAEPHSLCY NLTVLSRDGS VQSGFLAEGH LDGQLFLLCD RQKGRARPRG QWAEAVLGAE TWDTETEDLT ENGQELRRTL AHIKGQKGGR GDKYMKVLFG TEFNREERDG ITHQCWVSSS CNFRTTMNTK RILKTQSCLE RGSHL // ID H2RLY6_TAKRU Unreviewed; 258 AA. AC H2RLY6; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000001149}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000001149}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000001149} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000001149} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000001153; ENSTRUP00000001149; ENSTRUG00000000486. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 210 233 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 96 181 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 258 AA; 29147 MW; 7486E4F20FF9738A CRC64; GVHIAQRMYG CEWDDETGEK NGFRQDGYDG ADFISLKLKE GIWVAGKREA EITKHKWDQD EAQIEQQKFY YTQVCIHWLQ KYVNYGKSSL MRTELPSVSL LQKTPSSPVS CHATGFYPDR ATLSWRKGEE ELHEDVDHGE MLLNPDGTFQ MSVDLKVSSV PPEDWSSYKC VFQLSGGKEI TTTLDKNQIR TNWRKPWVRG DGAEDPSNTA VIAAVAVVVL VLVLAAVVGF LLYRKKKGKC TKPKGHSEVK EPLKPNPN // ID H2RLY7_TAKRU Unreviewed; 270 AA. AC H2RLY7; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000001150}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000001150}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000001150} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000001150} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H2RLY7; -. DR STRING; 31033.ENSTRUP00000001150; -. DR Ensembl; ENSTRUT00000001154; ENSTRUP00000001150; ENSTRUG00000000486. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2RLY7; -. DR OMA; YLEGICI; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 210 233 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 96 181 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 270 AA; 30391 MW; AFA8CCA8870CF20B CRC64; GVHIAQRMYG CEWDDETGEK NGFRQDGYDG ADFISLKLKE GIWVAGKREA EITKHKWDQD EAQIEQQKFY YTQVCIHWLQ KYVNYGKSSL MRTELPSVSL LQKTPSSPVS CHATGFYPDR ATLSWRKGEE ELHEDVDHGE MLLNPDGTFQ MSVDLKVSSV PPEDWSSYKC VFQLSGGKEI TTTLDKNQIR TNWRKPWVRG DGAEDPSNTA VIAAVAVVVL VLVLAAVVGF LLYRKKKVIV CNCGFCSKNL CSDLTAKGHS EVKEPLKPNP // ID H2RX06_TAKRU Unreviewed; 203 AA. AC H2RX06; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000004676}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000004676}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000004676} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000004676} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H2RX06; -. DR Ensembl; ENSTRUT00000004703; ENSTRUP00000004676; ENSTRUG00000002033. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2RX06; -. DR OMA; LENECTQ; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}. FT DOMAIN 85 170 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 203 AA; 22935 MW; 5C4E110C85AD0EEF CRC64; CELDSETGEI SAFSKFGYDG EDLLELDLKT LHWTALTPKA LAVKPRWDSD EHRTLRISLY ITKVPERMKQ YSAIMKEHLE RTELPSVSLL QKTPSSPVSC HATGFYPDRA TLFWRKGEEE LHEDVDHGEM LLNPDGTFQM SVDLKVSSVP PEDWSSYKCV FQLSGAKEIT TTLDKNQIRT NWGETGEPPG ILISYFVIGI LAA // ID H2RYQ8_TAKRU Unreviewed; 372 AA. AC H2RYQ8; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000005279}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005279}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000005279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000005279} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H2RYQ8; -. DR STRING; 31033.ENSTRUP00000005279; -. DR Ensembl; ENSTRUT00000005312; ENSTRUP00000005279; ENSTRUG00000002296. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2RYQ8; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005622; C:intracellular; IEA:GOC. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 323 345 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 62 120 PI-PLC Y-box. FT {ECO:0000259|PROSITE:PS50008}. FT DOMAIN 206 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 372 AA; 42109 MW; 2D4E5980695F7C62 CRC64; RSVVACLLIS LSSFFYTNYF TVTHTLKYFY TGSFGVPNFP EFVAVGLVDD VPIIRYDSNT RRAQPKQEWM KEVTADDPQY WSKSTQTLLF TQQTLKINME IAEQRFNQTR GVHIIQKMCG CEWDDETGEK NGFDQFGYDG ADFISLKLKE GIWVAGKREA EITKHKWDQD EAQIEQQKFY YTQVCIHWLQ KYVNYGKSSL MRTELPSVSL LQKTPSSPVS CHATGFYPDR ATLSWRKGEE ELHEDVDHGE ILLNPDGTFQ TSVDLKVSSV PPEDWSSYKC LFQLSGVKEI TTTLDKNQIR TNWGKSGVLL VSSPAEDPSN TTVIAAVAVV VLALVLAAVV GFLLYRKKKV AGKCTKTEGH SEVKEPLKPN PN // ID H2RYQ9_TAKRU Unreviewed; 370 AA. AC H2RYQ9; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000005280}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005280}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000005280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000005280} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000005313; ENSTRUP00000005280; ENSTRUG00000002296. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005622; C:intracellular; IEA:GOC. DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 370 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003571399. FT TRANSMEM 311 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 57 115 PI-PLC Y-box. FT {ECO:0000259|PROSITE:PS50008}. FT DOMAIN 201 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 370 AA; 41907 MW; 92C4543DA078627A CRC64; MRVVLSLTVV FHLTSAVTHT LKYFYTGSFG VPNFPEFVAV GLVDDVPIIR YDSNTRRAQP KQEWMKEVTA DDPQYWSKST QTLLFTQQTL KINMEIAEQR FNQTRGVHII QKMCGCEWDD ETGEKNGFDQ FGYDGADFIS LKLKEGIWVA GKREAEITKH KWDQDEAQIE QQKFYYTQVC IHWLQKYVNY GKSSLMRTEL PSVSLLQKTP SSPVSCHATG FYPDRATLSW RKGEEELHED VDHGEILLNP DGTFQTSVDL KVSSVPPEDW SSYKCLFQLS GVKEITTTLD KNQIRTNWGK SGAEDPSNTT VIAAVAVVVL ALVLAAVVGF LLYRKKKVIV WNCGFCSKNL CSDLTAEGHS EVKEPLKPNP // ID H2RYR0_TAKRU Unreviewed; 345 AA. AC H2RYR0; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000005281}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005281}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000005281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000005281} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000005314; ENSTRUP00000005281; ENSTRUG00000002296. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005622; C:intracellular; IEA:GOC. DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 320 342 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 70 128 PI-PLC Y-box. FT {ECO:0000259|PROSITE:PS50008}. FT DOMAIN 214 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 345 AA; 39497 MW; FBFED05195A9DF92 CRC64; CVYDKRICFL YIKMRVVLSL TVVFHLTSAV THTLKYFYTG SFGVPNFPEF VAVGLVDDVP IIRYDSNTRR AQPKQEWMKE VTADDPQYWS KSTQTLLFTQ QTLKINMEIA EQRFNQTRGV HIIQKMCGCE WDDETGEKNG FDQFGYDGAD FISLKLKEGI WVAGKREAEI TKHKWDQDEA QIEQQKFYYT QVCIHWLQKY VNYGKSSLMR TELPSVSLLQ KTPSSPVSCH ATGFYPDRAT LSWRKGEEEL HEDVDHGEIL LNPDGTFQTS VDLKVSSVPP EDWSSYKCLF QLSGVKEITT TLDKNQIRTN WAEDPSNTTV IAAVAVVVLA LVLAAVVGFL LYRKK // ID H2S0E1_TAKRU Unreviewed; 358 AA. AC H2S0E1; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000005862}; GN Name=LOC101063259 {ECO:0000313|Ensembl:ENSTRUP00000005862}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005862, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000005862} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000005862} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000005898; ENSTRUP00000005862; ENSTRUG00000002529. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 358 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003572513. FT TRANSMEM 310 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 358 AA; 40624 MW; FAB56DC03C7AF42A CRC64; MKSLDFLLLL ALLSLPDSSA VTHTLKYFYT ASSGVPNFPE FVAFGMVDDV QMVRYDSNTG RLQFKQEWMK EATADDPQFW DKKTGILMGA QQWFKVNIEI LKQRFNQTGG KLIFNTDMYG CEWDDETREK NGFFQDGYDG ADFISLKLKE GIWVAAKREA EISKHKWDQD EALIEQLMDY YTQICIKWLQ KFVNYGKSSL MRTELPSVSL LQKTPSSPVR CHATGFYPDT AVMSWRKGEE ELHEDVDHGE MLLNPDGTFQ ASVDLNVSSV PPEDWSSYKC VFQLSGGKEI NTTLDKNQIR TNWKDPSNTA VIAAVAVVVL ALVLIGVVGF LLYRKKKGKC TKPEGHSEVK VPLKPNPI // ID H2S0E2_TAKRU Unreviewed; 358 AA. AC H2S0E2; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000005863}; GN Name=LOC101063259 {ECO:0000313|Ensembl:ENSTRUP00000005863}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005863, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000005863} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000005863} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000005899; ENSTRUP00000005863; ENSTRUG00000002529. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 358 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003571488. FT TRANSMEM 310 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 358 AA; 40681 MW; 58A06C498444CDA8 CRC64; MKSLDFLLLL ALLSLPDSSA VTHTLKYFYT ASSGVPNFPE FVAFGMVDDV QMVRYDSNTG RLQFKQEWMK EATADDPQFW DKKTGILMGA QQWFKVNIEI LKQRFNQTGV ENIFKVDMYG CEWDDETREK NGFFQDGYDG ADFISLKLKE GIWVAAKREA EISKHKWDQD EALIEQLMDY YTQICIKWLQ KFVNYGKSSL MRTELPSVSL LQKTPSSPVR CHATGFYPDT AVMSWRKGEE ELHEDVDHGE MLLNPDGTFQ ASVDLNVSSV PPEDWSSYKC VFQLSGGKEI NTTLDKNQIR TNWKDPSNTA VIAAVAVVVL ALVLIGVVGF LLYRKKKGKC TKPEGHSEVK VPLKPNPI // ID H2S0E3_TAKRU Unreviewed; 371 AA. AC H2S0E3; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000005864}; GN Name=LOC101063259 {ECO:0000313|Ensembl:ENSTRUP00000005864}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005864, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000005864} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000005864} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 31033.ENSTRUP00000005864; -. DR Ensembl; ENSTRUT00000005900; ENSTRUP00000005864; ENSTRUG00000002529. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2S0E3; -. DR OMA; FQRMIGC; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 371 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003572501. FT TRANSMEM 321 344 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 371 AA; 42049 MW; 30AE9CA1C1D35C14 CRC64; MKSLDFLLLL ALLSLPDSSA VTHTLKYFYT ASSGVPNFPE FVAFGMVDDV QMVRYDSNTG RLQFKQEWMK EATADDPQFW DKKTGILMGA QQWFKVNIEI LKQRFNQTGE RIYLVFLNMY GCEWDDETRE KNGFFQDGYD GADFISLKLK EGIWVAAKRE AEISKHKWDQ DEALIEQLMD YYTQICIKWL QKFVNYGKSS LMRTELPSVS LLQKTPSSPV RCHATGFYPD TAVMSWRKGE EELHEDVDHG EMLLNPDGTF QASVDLNVSS VPPEDWSSYK CVFQLSGGKE INTTLDKNQI RTNWRKPGVR GDGAEDPSNT AVIAAVAVVV LALVLIGVVG FLLYRKKKVA GKCTKPEGHS EVKVPLKPNP I // ID H2S0E4_TAKRU Unreviewed; 371 AA. AC H2S0E4; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000005865}; GN Name=LOC101063259 {ECO:0000313|Ensembl:ENSTRUP00000005865}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005865, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000005865} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000005865} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000005901; ENSTRUP00000005865; ENSTRUG00000002529. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 371 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003571600. FT TRANSMEM 321 344 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 371 AA; 41875 MW; 4EA27439E772A0B7 CRC64; MKSLDFLLLL ALLSLPDSSA VTHTLKYFYT ASSGVPNFPE FVAFGMVDDV QMVRYDSNTG RLQFKQEWMK EATADDPQFW DKKTGILMGA QQWFKVNIEI LKQRFNQTGG SMRTVQVDMY GCEWDDETRE KNGFFQDGYD GADFISLKLK EGIWVAAKRE AEISKHKWDQ DEALIEQLMD YYTQICIKWL QKFVNYGKSS LMRTELPSVS LLQKTPSSPV RCHATGFYPD TAVMSWRKGE EELHEDVDHG EMLLNPDGTF QASVDLNVSS VPPEDWSSYK CVFQLSGGKE INTTLDKNQI RTNWRKPGVR GDGAEDPSNT AVIAAVAVVV LALVLIGVVG FLLYRKKKVA GKCTKPEGHS EVKVPLKPNP I // ID H2S0E5_TAKRU Unreviewed; 306 AA. AC H2S0E5; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000005866}; GN Name=LOC101063259 {ECO:0000313|Ensembl:ENSTRUP00000005866}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005866, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000005866} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000005866} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H2S0E5; -. DR Ensembl; ENSTRUT00000005902; ENSTRUP00000005866; ENSTRUG00000002529. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 306 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003572119. FT DOMAIN 206 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 306 AA; 35166 MW; 8646A56792BD5E8F CRC64; MKSLDFLLLL ALLSLPDSSA VTHTLKYFYT ASSGVPNFPE FVAFGMVDDV QMVRYDSNTG RLQFKQEWMK EATADDPQFW DKKTGILMGA QQWFKVNIEI LKQRFNQTGG KCPHLSDMYG CEWDDETREK NGFFQDGYDG ADFISLKLKE GIWVAAKREA EISKHKWDQD EALIEQLMDY YTQICIKWLQ KFVNYGKSSL MRTELPSVSL LQKTPSSPVR CHATGFYPDT AVMSWRKGEE ELHEDVDHGE MLLNPDGTFQ ASVDLNVSSV PPEDWSSYKC VFQLSGGKEI NTTLDKNQIR TNWRKP // ID H2S0E6_TAKRU Unreviewed; 369 AA. AC H2S0E6; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000005867}; GN Name=LOC101063259 {ECO:0000313|Ensembl:ENSTRUP00000005867}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005867, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000005867} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000005867} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000005903; ENSTRUP00000005867; ENSTRUG00000002529. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 369 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003572516. FT TRANSMEM 319 342 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 369 AA; 41741 MW; D34570D4330726FE CRC64; MKSLDFLLLL ALLSLPDSSA VTHTLKYFYT ASSGVPNFPE FVAFGMVDDV QMVRYDSNTG RLQFKQEWMK EATADDPQFW DKKTGILMGA QQWFKVNIEI LKQRFNQTGV VHFSRNMYGC EWDDETREKN GFFQDGYDGA DFISLKLKEG IWVAAKREAE ISKHKWDQDE ALIEQLMDYY TQICIKWLQK FVNYGKSSLM RTELPSVSLL QKTPSSPVRC HATGFYPDTA VMSWRKGEEE LHEDVDHGEM LLNPDGTFQA SVDLNVSSVP PEDWSSYKCV FQLSGGKEIN TTLDKNQIRT NWRKPGVRGD GAEDPSNTAV IAAVAVVVLA LVLIGVVGFL LYRKKKVAGK CTKPEGHSEV KVPLKPNPI // ID H2S0E7_TAKRU Unreviewed; 369 AA. AC H2S0E7; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000005868}; GN Name=LOC101063259 {ECO:0000313|Ensembl:ENSTRUP00000005868}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005868, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000005868} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000005868} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000005904; ENSTRUP00000005868; ENSTRUG00000002529. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 369 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003571492. FT TRANSMEM 319 342 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 369 AA; 41692 MW; F03A704F83320657 CRC64; MKSLDFLLLL ALLSLPDSSA VTHTLKYFYT ASSGVPNFPE FVAFGMVDDV QMVRYDSNTG RLQFKQEWMK EATADDPQFW DKKTGILMGA QQWFKVNIEI LKQRFNQTGA AEIYKDMYGC EWDDETREKN GFFQDGYDGA DFISLKLKEG IWVAAKREAE ISKHKWDQDE ALIEQLMDYY TQICIKWLQK FVNYGKSSLM RTELPSVSLL QKTPSSPVRC HATGFYPDTA VMSWRKGEEE LHEDVDHGEM LLNPDGTFQA SVDLNVSSVP PEDWSSYKCV FQLSGGKEIN TTLDKNQIRT NWRKPGVRGD GAEDPSNTAV IAAVAVVVLA LVLIGVVGFL LYRKKKVAGK CTKPEGHSEV KVPLKPNPI // ID H2S0E8_TAKRU Unreviewed; 368 AA. AC H2S0E8; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000005869}; GN Name=LOC101063259 {ECO:0000313|Ensembl:ENSTRUP00000005869}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005869, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000005869} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000005869} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000005905; ENSTRUP00000005869; ENSTRUG00000002529. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 368 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003572502. FT TRANSMEM 318 341 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 204 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 41598 MW; 7B17C80BB51B3950 CRC64; MKSLDFLLLL ALLSLPDSSA VTHTLKYFYT ASSGVPNFPE FVAFGMVDDV QMVRYDSNTG RLQFKQEWMK EATADDPQFW DKKTGILMGA QQWFKVNIEI LKQRFNQTGG VHIYQMYGCE WDDETREKNG FFQDGYDGAD FISLKLKEGI WVAAKREAEI SKHKWDQDEA LIEQLMDYYT QICIKWLQKF VNYGKSSLMR TELPSVSLLQ KTPSSPVRCH ATGFYPDTAV MSWRKGEEEL HEDVDHGEML LNPDGTFQAS VDLNVSSVPP EDWSSYKCVF QLSGGKEINT TLDKNQIRTN WRKPGVRGDG AEDPSNTAVI AAVAVVVLAL VLIGVVGFLL YRKKKVAGKC TKPEGHSEVK VPLKPNPI // ID H2S0E9_TAKRU Unreviewed; 362 AA. AC H2S0E9; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000005870}; GN Name=LOC101063259 {ECO:0000313|Ensembl:ENSTRUP00000005870}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005870, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000005870} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000005870} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000005906; ENSTRUP00000005870; ENSTRUG00000002529. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003571602. FT TRANSMEM 312 335 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40938 MW; 0EFF095517B9AFBA CRC64; MKSLDFLLLL ALLSLPDSSA VTHTLKYFYT ASSGVPNFPE FVAFGMVDDV QMVRYDSNTG RLQFKQEWMK EATADDPQFW DKKTGILMGA QQWFKVNIEI LKQRFNQTGA VGGDKHQHMY GCEWDDETRE KNGFFQDGYD GADFISLKLK EGIWVAAKRE AEISKHKWDQ DEALIEQLMD YYTQICIKWL QKFVNYGKSS LMRTELPSVS LLQKTPSSPV RCHATGFYPD TAVMSWRKGE EELHEDVDHG EMLLNPDGTF QASVDLNVSS VPPEDWSSYK CVFQLSGGKE INTTLDKNQI RTNWTEDPSN TAVIAAVAVV VLALVLIGVV GFLLYRKKKV AGKCTKPEGH SEVKVPLKPN PI // ID H2S0F0_TAKRU Unreviewed; 360 AA. AC H2S0F0; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000005871}; GN Name=LOC101063259 {ECO:0000313|Ensembl:ENSTRUP00000005871}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005871, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000005871} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000005871} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000005907; ENSTRUP00000005871; ENSTRUG00000002529. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 360 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003572122. FT TRANSMEM 310 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 360 AA; 40812 MW; 0222B97B34F61C36 CRC64; MKSLDFLLLL ALLSLPDSSA VTHTLKYFYT ASSGVPNFPE FVAFGMVDDV QMVRYDSNTG RLQFKQEWMK EATADDPQFW DKKTGILMGA QQWFKVNIEI LKQRFNQTGG YNINQDMYGC EWDDETREKN GFFQDGYDGA DFISLKLKEG IWVAAKREAE ISKHKWDQDE ALIEQLMDYY TQICIKWLQK FVNYGKSSLM RTELPSVSLL QKTPSSPVRC HATGFYPDTA VMSWRKGEEE LHEDVDHGEM LLNPDGTFQA SVDLNVSSVP PEDWSSYKCV FQLSGGKEIN TTLDKNQIRT NWTEDPSNTA VIAAVAVVVL ALVLIGVVGF LLYRKKKVAG KCTKPEGHSE VKVPLKPNPI // ID H2S7D6_TAKRU Unreviewed; 336 AA. AC H2S7D6; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000008308}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000008308}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000008308} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000008308} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000008357; ENSTRUP00000008308; ENSTRUG00000003539. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 309 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 197 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 336 AA; 37912 MW; E65EB94703526B06 CRC64; FGLVLLSFQV SASAVQPSLT IYYSLSSGLP NIPEFFASVE VSGLEAGYCD TTKKKVEPKT NWAKTFLDHH QEQLDWYTAE CVERFPAYMK YWMYNVKEIY NQTGAGVHVI QRLDHCELDS ETGEISAFSK FGYDGEDLLE LDLKTLHWTA LTPKALAVKP RWDSDSVHHQ ERMKQYSAIM KEHLERTGRD TLTFFPPELP SVSLLQKTPS SPVSCHATGF YPDRATLSWR KGEEELHEDV DHGEMLLNPD GTFQMSVDLN VSSVPPEDWS SYKCVFQLSG AKEITTTLDK NQIRTNWGET VSSSNHPGAA VIIVILVVLL LPVGVAIRFC IRTRNN // ID H2S7D7_TAKRU Unreviewed; 363 AA. AC H2S7D7; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000008309}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000008309}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000008309} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000008309} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H2S7D7; -. DR Ensembl; ENSTRUT00000008358; ENSTRUP00000008309; ENSTRUG00000003539. DR eggNOG; ENOG410KH3D; Eukaryota. DR eggNOG; ENOG4110RPC; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2S7D7; -. DR OMA; ADIVNIM; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 363 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003571877. FT TRANSMEM 317 339 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 363 AA; 40769 MW; AB7805FDFF9A7829 CRC64; PDKMRKLLFM LLLSCKSASA VQPSLTIYYS LSSGLPNIPE FFASVEVSGL EAGYCDTTKK KVEPKTNWAK TFLDHHQEQL DWYTAECVER FPAYMKYWMY NVKEIYNQTG AGVHVIQRLD HCELDSETGE ISAFSKFGYD GEDLLELDLK TLHWTALTPK ALAVKPRWDS DEHRTLWISL YITKLTLVLL MNHHETNDGF LSVPPELPSV SLLQKTPSSP VSCHATGFYP DRATLSWRKG EEELHEDVDH GEMLLNPDGT FQMSVDLNVS SVPPEDWSSY KCVFQLSGAK EITTTLDKNQ IRTNWGETVS SSNHPGAAVI IVILVVLLLP VGVAIRFCIR TRNNPAAFSG DPSQQAASHM LNN // ID H2S7D8_TAKRU Unreviewed; 343 AA. AC H2S7D8; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000008310}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000008310}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000008310} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000008310} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000008359; ENSTRUP00000008310; ENSTRUG00000003539. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 343 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003572301. FT TRANSMEM 309 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 343 AA; 38899 MW; 1B8C2D1990142D5E CRC64; MRKLLFMLLL SCKSASAVQP SLTIYYSLSS GLPNIPEFFA SVEVSGLEAG YCDTTKKKVE PKTNWAKTFL DHHQEQLDWY TAECVERFPA YMKYWMYNVK EIYNQTGAGV HVIQRLDHCE LDSETGEISA FSKFGYDGED LLELDLKTLH WTALTPKALA VKPRWDSDEH RTLWISLYIT KKMKQYSAIM KEHLERTELP SVSLLQKTPS SPVSCHATGF YPDRATLSWR KGEEELHEDV DHGEMLLNPD GTFQMSVDLN VSSVPPEDWS SYKCVFQLSG AKEITTTLDK NQIRTNWGET VSSSNHPGAA VIIVILVVLL LPVGVAIRFC IRTRNNPGEQ LKP // ID H2S7D9_TAKRU Unreviewed; 340 AA. AC H2S7D9; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000008311}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000008311}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000008311} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000008311} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000008360; ENSTRUP00000008311; ENSTRUG00000003539. DR eggNOG; ENOG410KH3D; Eukaryota. DR eggNOG; ENOG4110RPC; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 340 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003572717. FT TRANSMEM 313 335 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 201 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 38452 MW; 09F2C0DF169EC024 CRC64; MRKLLFMLLL SCKSASAVQP SLTIYYSLSS GLPNIPEFFA SVEVSGLEAG YCDTTKKKVE PKTNWAKTFL DHHQEQLDWY TAECVERFPA YMKYWMYNVK EIYNQTGAGV HVIQRLDHCE LDSETGEISA FSKFGYDGED LLELDLKTLH WTALTPKALA VKPRWDSDEH RTLWISLYIT KTQQDQMNHH ETNDGFLSVP PELPSVSLLQ KTPSSPVSCH ATGFYPDRAT LSWRKGEEEL HEDVDHGEML LNPDGTFQMS VDLNVSSVPP EDWSSYKCVF QLSGAKEITT TLDKNQIRTN WGETVSSSNH PGAAVIIVIL VVLLLPVGVA IRFCIRTRNN // ID H2S7E0_TAKRU Unreviewed; 342 AA. AC H2S7E0; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000008312}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000008312}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000008312} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000008312} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000008361; ENSTRUP00000008312; ENSTRUG00000003539. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 298 320 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 183 268 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 342 AA; 38629 MW; 07FECBA9FF6C8A1B CRC64; LSCKSASAVQ PSLTIYYSLS SGLPNIPEFF ASVEVSGLEA GYCDTTKKKV EPKTNWAKTF LDHHQEQLDW YTAECVERFP AYMKYWMYNV KEIYNQTGAG VHVIQRLDHC ELDSETGEIS AFSKFGYDGE DLLELDLKTL HWTALTPKAL AVKPRWDSDE HRTLWISLYI TNMKEHLERT ELPSVSLLQK TPSSPVSCHA TGFYPDRATL SWRKGEEELH EDVDHGEMLL NPDGTFQMSV DLNVSSVPPE DWSSYKCVFQ LSGAKEITTT LDKNQIRTNW GETVNITSQV SSSNHPGAAV IIVILVVLLL PVGVAIRFCI RTRNNPVNQT SLYSVPVVRR LH // ID H2S7E1_TAKRU Unreviewed; 228 AA. AC H2S7E1; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000008313}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000008313}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000008313} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000008313} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000008362; ENSTRUP00000008313; ENSTRUG00000003539. DR eggNOG; ENOG410KH3D; Eukaryota. DR eggNOG; ENOG4110RPC; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}. FT DOMAIN 124 212 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 228 AA; 26015 MW; F7DBF91230254566 CRC64; DSKSKERRHR SAYMKYWMYN VKEIYNQTGA GVHVIQRLDH CELDSETGEI SAFSKFGYDG EDLLELDLKT LHWTALTPKA LAVKPRWDSD EHRTLWISLY ITKLTLVLLM NHHETNDGFL SVPPELPSVS LLQKTPSSPV SCHATGFYPD RATLSWRKGE EELHEDVDHG EMLLNPDGTF QMSVDLNVSS VPPEDWSSYK CVFQLSGAKE ITTTLDKNQI RTNWGETG // ID H2SAD4_TAKRU Unreviewed; 340 AA. AC H2SAD4; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000009360}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000009360, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000009360} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000009360} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000009415; ENSTRUP00000009360; ENSTRUG00000003955. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 340 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003572007. FT TRANSMEM 312 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 39344 MW; 5AE6CB459D9CEAFA CRC64; KRLSRVLFSI ICFSFHVLFS EKHSLHYIYT ATSQPISRQG IHEFTAMGVL DGNVIDYFDS DAQKKVPRQK WMEKELDKSY WEKGTESRKS KQQWFKVNIN ILKTRYRQND SDIHILQWMH GCDADIDHGE PRFLHGIDKY SYDGANFLAF NENQEIWDAR DDAARETKTR WDKVQVLREY TMAYLQKECV TWLKRFLDYQ NKNEIPAKPD LYVFITGAKD PTNMVLKCMA TGFTPTNTVL QIKLGGRVLT REDGVNSTDI LPNGDGTFQK TDYVEIPRSD NSDYYCELSH TPSSLRVVKF WDKKAPDDTT KILLAVRISL GAVILIGGLL ILVIKKFCIG // ID H2SAD5_TAKRU Unreviewed; 353 AA. AC H2SAD5; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000009361}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000009361, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000009361} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000009361} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H2SAD5; -. DR STRING; 31033.ENSTRUP00000009361; -. DR Ensembl; ENSTRUT00000009416; ENSTRUP00000009361; ENSTRUG00000003955. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2SAD5; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G0BBK; -. DR TreeFam; TF334519; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 290 312 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 187 276 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 353 AA; 40618 MW; FE3DB08A171137FF CRC64; HSLHYIYTAT SQPISRQGIH EFTAMGVLDG NVIDYFDSDA QKKVPRQKWM EKELDKSYWE KGTESRKSKQ QWFKVNINIL KTRYRQNDSD IHILQWMHGC DADIDHGEPR FLHGIDKYSY DGANFLAFNE NQEIWDARDD AARETKTRWD KVQVLREYTM AYLQKECVTW LKRFLDYQNK NEIPAKPDLY VFITGAKDPT NMVLKCMATG FTPTNTVLQI KLGGRVLTRE DGVNSTDILP NGDGTFQKTD YVEIPRSDNS DYYCELSHTP SSLRVVKFWD KKAPDDTTKI LLAVRISLGA VILIGGLLIL VIKKFCIDSG SQDSPFFLPV AQSSKSNEEK ECEVKLCDPN SRE // ID H2SAD6_TAKRU Unreviewed; 293 AA. AC H2SAD6; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000009362}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000009362, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000009362} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000009362} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000009417; ENSTRUP00000009362; ENSTRUG00000003955. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}. FT DOMAIN 190 279 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 293 AA; 34020 MW; 65A5FC7F247D5ADD CRC64; SEKHSLHYIY TATSQPISRQ GIHEFTAMGV LDGNVIDYFD SDAQKKVPRQ KWMEKELDKS YWEKGTESRK SKQQWFKVNI NILKTRYRQN DSDIHILQWM HGCDADIDHG EPRFLHGIDK YSYDGANFLA FNENQEIWDA RDDAARETKT RWDKVQVLRE YTMAYLQKEC VTWLKRFLDY QNKNEIPAKP DLYVFITGAK DPTNMVLKCM ATGFTPTNTV LQIKLGGRVL TREDGVNSTD ILPNGDGTFQ KTDYVEIPRS DNSDYYCELS HTPSSLRVVK FWDSGSQDSP VSI // ID H2SAD7_TAKRU Unreviewed; 266 AA. AC H2SAD7; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000009363}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000009363, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000009363} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000009363} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000009418; ENSTRUP00000009363; ENSTRUG00000003955. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}. FT DOMAIN 184 266 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 266 AA; 31038 MW; 7E60320874BC7C14 CRC64; HSLHYIYTAT SQPISRQGIH EFTAMGVLDG NVIDYFDSDA QKKVPRQKWM EKELDKSYWE KGTESRKSKQ QWFKVNINIL KTRYRQNDSD IHILQWMHGC DADIDHGEPR FLHGIDKYSY DGANFLAFNE NQEIWDARDD AARETKTRWD KVQVLREYTM AYLQKECVTW LKRFLDYQNK NEIPGNINLI ESAKDPTNMV LKCMATGFTP TNTVLQIKLG GRVLTREDGV NSTDILPNGD GTFQKTDYVE IPRSDNSDYY CELSHT // ID H2SCQ6_TAKRU Unreviewed; 220 AA. AC H2SCQ6; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000010186}; DE Flags: Fragment; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000010186, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000010186} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSTRUP00000010186}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000010186} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 31033.ENSTRUP00000010186; -. DR Ensembl; ENSTRUT00000010242; ENSTRUP00000010186; ENSTRUG00000004298. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2SCQ6; -. DR OMA; TENARWI; -. DR TreeFam; TF334519; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 196 218 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 93 182 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSTRUP00000010186}. SQ SEQUENCE 220 AA; 24962 MW; 055F04231D4CCFED CRC64; XWMHGCDADI DHGEPTFLHG IEKYSYDGAN FLAFNENQEI WDARDDAARE TKTRWDKVQV LREYTMAYLQ KECVTWLTRF LKYQNENEVP AKPDLYVFIT GAKDPTNMVL KCMATGFTPT NTVLQIKLGG RVLTREDGLH STDILPNGDG TFQKTEYVEI PKSDNSDYYC ELSHTPSSLR VVKFWDKKAP DNTTTILLAV GIPVVVVILI GGLLILVIKK // ID H2V3C9_TAKRU Unreviewed; 335 AA. AC H2V3C9; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000043711}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000043711}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000043711} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000043711} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H2V3C9; -. DR Ensembl; ENSTRUT00000043857; ENSTRUP00000043711; ENSTRUG00000017062. DR eggNOG; ENOG410KFJH; Eukaryota. DR eggNOG; ENOG4110T8Z; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2V3C9; -. DR OMA; LENECIE; -. DR OrthoDB; EOG091G0TWV; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 308 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 203 277 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 335 AA; 38793 MW; 39DE7F6753D68860 CRC64; SYMLIITIMT QNKVKLFAAA EKHYLRYFLT ASTGATNFQD FLAQVVADDL QGGYCDSNGA KPRDEWAERI VEDDPEELKY YTDACVHYVH TYRAQVKNFN QQFNQSEGIH TFQRIHGCEW DDKTGKVTAF NQFGYDGEDF IALDPETMTW VAAKPQALIT KRKWDNEITY LEIKKIFNTE TCPKRLKKFL QYIQKFHQRD VQPSVFLLQK TPSSPVSCHA TGFYPKVAVM FWRKDGEKLH EEVEYMEILP NHDGTFQRSV DLKLSSVSPE EWSRYECVFQ LPGVVEDIAI VLDTSVIRTN WGKMAPKVSY WVVAGVVVVV LLLLASIMGY FIWKR // ID H2V3D0_TAKRU Unreviewed; 351 AA. AC H2V3D0; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000043712}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000043712}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000043712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000043712} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000043858; ENSTRUP00000043712; ENSTRUG00000017063. DR eggNOG; ENOG410KFJH; Eukaryota. DR eggNOG; ENOG4110T8Z; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 351 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003575822. FT TRANSMEM 312 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 351 AA; 41077 MW; 78F6A52520C76587 CRC64; AKQWKKLLMK GMNWQLFLLL HLYSLSAKKH SLRYFLTESS GVTNLPEFVA QLMVDDLLGG YCDSNRKIPK PRDWAVKMIL EDPKQFEIYE NECDRYQHKY RTQIKNLKEQ FNQTEGIHIF QRIHGCEWDD ETDKKTAFNQ FGYDGEDFIA LDPETMTWVA AKPQALITKR NWDNEIIYLE IKKLFNAEIC PKRLRKYLQY IQKFHQRDVQ PSVFLLQKTP SSPVSCHATG FYPKEAVMFW RKDGEKLHEE VEYMEILPNH DGTFQRSVDL KLSSVSPEEW SRYECVFQLP GVVEDIAIVL DTIPPAEFPT GVVAGVVVVV LLLLASIMGY FIWKRPNKGM MKTSCYSKYC V // ID H2V3D1_TAKRU Unreviewed; 336 AA. AC H2V3D1; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000043713}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000043713}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000043713} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000043713} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000043859; ENSTRUP00000043713; ENSTRUG00000017063. DR eggNOG; ENOG410KFJH; Eukaryota. DR eggNOG; ENOG4110T8Z; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 310 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 276 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 336 AA; 39094 MW; D39020D22738D252 CRC64; TLEEASSDLG LLENDQGKKK HSLRYFLTES SGVTNLPEFV AQLMVDDLLG GYCDSNRKIP KPRDWAVKMI LEDPKQFEIY ENECDRYQHK YRTQIKNLKE QFNQTEGIHI FQRIHGCEWD DETDKKTAFN QFGYDGEDFI ALDPETMTWV AAKPQALITK RNWDNEIIYL EIKKLFNAEI CPKRLRKYLQ YIQKFHQRDV QPSVFLLQKT PSSPVSCHAT GFYPKEAVMF WRKDGEKLHE EVEYMEILPN HDGTFQRSVD LKLSSVSPEE WSRYECVFQL PGVVEDIAIV LDTSVIRTNW VPPAEFPTGV VAGVVVVVLL LLASIMGYFI WKRPNK // ID H2V3D2_TAKRU Unreviewed; 338 AA. AC H2V3D2; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000043714}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000043714}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000043714} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000043714} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000043860; ENSTRUP00000043714; ENSTRUG00000017063. DR eggNOG; ENOG410KFJH; Eukaryota. DR eggNOG; ENOG4110T8Z; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 308 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 274 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 338 AA; 39289 MW; 29AFAAD686B744F6 CRC64; IAMVVTGLLK LYIFSAEKHS LRYFLTESSG VTNLPEFVAQ LMVDDLLGGY CDSNRKIPKP RDWAVKMILE DPKQFEIYEN ECDRYQHKYR TQIKNLKEQF NQTEGIHIFQ RIHGCEWDDE TDKKTAFNQF GYDGEDFIAL DPETMTWVAA KPQALITKRN WDNEIIYLEI KKLFNAEICP KRLRKYLQYI QKFHQRDVQP SVFLLQKTPS SPVSCHATGF YPKEAVMFWR KDGEKLHEEV EYMEILPNHD GTFQRSVDLK LSSVSPEEWS RYECVFQLPG VVEDIAIVLD TSVIRTNWVP PAEFPTGVVA GVVVVVLLLL ASIMGYFIWK RPNKGGFL // ID H2V3D3_TAKRU Unreviewed; 340 AA. AC H2V3D3; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000043715}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000043715}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000043715} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000043715} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000043861; ENSTRUP00000043715; ENSTRUG00000017063. DR eggNOG; ENOG410KFJH; Eukaryota. DR eggNOG; ENOG4110T8Z; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 312 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 204 278 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 39573 MW; F273A17FCA0D936F CRC64; AMVVTGLLNK IINDYIKVCT EKHSLRYFLT ESSGVTNLPE FVAQLMVDDL LGGYCDSNRK IPKPRDWAVK MILEDPKQFE IYENECDRYQ HKYRTQIKNL KEQFNQTEGI HIFQRIHGCE WDDETDKKTA FNQFGYDGED FIALDPETMT WVAAKPQALI TKRNWDNEII YLEIKKLFNA EICPKRLRKY LQYIQKFHQR DVQPSVFLLQ KTPSSPVSCH ATGFYPKEAV MFWRKDGEKL HEEVEYMEIL PNHDGTFQRS VDLKLSSVSP EEWSRYECVF QLPGVVEDIA IVLDTSVIRT NWVPPAEFPT GVVAGVVVVV LLLLASIMGY FIWKRPNKGM // ID H2V3D4_TAKRU Unreviewed; 367 AA. AC H2V3D4; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JUN-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000043716}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000043716}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000043716} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000043716} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H2V3D4; -. DR STRING; 31033.ENSTRUP00000043716; -. DR Ensembl; ENSTRUT00000043862; ENSTRUP00000043716; ENSTRUG00000017063. DR eggNOG; ENOG410KFJH; Eukaryota. DR eggNOG; ENOG4110T8Z; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2V3D4; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 306 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 192 266 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 367 AA; 43100 MW; F779B35D4E6FE12C CRC64; LHLYSLSAKK HSLRYFLTES SGVTNLPEFV AQLMVDDLLG GYCDSNRKIP KPRDWAVKMI LEDPKQFEIY ENECDRYQHK YRTQIKNLKE QFNQTEGIHI FQRIHGCEWD DETDKKTAFN QFGYDGEDFI ALDPETMTWV AAKPQALITK RNWDNEIIYL EIKKLFNAEI CPKRLRKYLQ YIQKFHQRDV QPSVFLLQKT PSSPVSCHAT GFYPKEAVMF WRKDGEKLHE EVEYMEILPN HDGTFQRSVD LKLSSVSPEE WSRYECVFQL PGVVEDIAIV LDTSVIRTNW GKMAPKWVPP AEFPTGVVAG VVVVVLLLLA SIMGYFIWKR PNKVENTAKY NLVKISHFQL YTHRLNTLRL FNHRERK // ID H2ZRX3_LATCH Unreviewed; 193 AA. AC H2ZRX3; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000000144}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000000144, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000000144} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000000144}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000000144} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01279416; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2ZRX3; -. DR Ensembl; ENSLACT00000000145; ENSLACP00000000144; ENSLACG00000000127. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}. FT DOMAIN 18 190 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 193 AA; 22402 MW; DD7C3DB03F0F4860 CRC64; CKQVLPSYKY SHFISIRKHS LHYICTGIAG DPTFPEFILV VVLDGTQIGY YDSNTKTTVS KLDGLNKQTD LDWDVYISYA TQQQATFPLK LNKIMKRANH TAGFHIYQRL VGCELDANGN MRGFNQHGYD GEDILSFDKD NLQWTAASQL AVVTKDNWNM NREDCRDTKY FLEETCIRWL KKYVKHQQDT ITR // ID H2ZTH9_LATCH Unreviewed; 341 AA. AC H2ZTH9; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000000700}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000000700, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000000700} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000000700}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000000700} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01255751; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01255752; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01255753; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2ZTH9; -. DR Ensembl; ENSLACT00000000706; ENSLACP00000000700; ENSLACG00000000626. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2ZTH9; -. DR OMA; CERDENT; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 341 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003579548. FT TRANSMEM 295 317 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 280 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 341 AA; 39014 MW; 38A1FC139690270C CRC64; MLLWALLLQK WTILIFLLPG KHSLHYICTG IAGDPTFPEF ILVVVLDGTQ IGYYDSNMKT IASKLDGLNK QTDLDWDVYI SYATQQQATF PLKLNKIMKW ANHTAGFHIY QRLVGCELDA NENMRGFNQH GYDSEDILSF DKDNLQWTAA SQLAVVMKDN WNMNREDCRD TKYFLEETCI QWLKKYVKHQ TCVCTVLVPP EVSIRARKSE NSETLTLTCM ATGFYPCDIE VNWIKNGDTR LVLPNEDRTF QIQKFIEIHA ADTNTYSCQV EHSSLNMTLT YAVPQTVDPR NTTRMVVIIG VILIVGFIAA IAAYLLSRKK RETSGKRIGT DIIQTFDNVQ I // ID H2ZTI9_LATCH Unreviewed; 184 AA. AC H2ZTI9; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000000710}; GN Name=LOC102357613 {ECO:0000313|Ensembl:ENSLACP00000000710}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000000710, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000000710} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000000710}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000000710} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01274746; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2ZTI9; -. DR Ensembl; ENSLACT00000000716; ENSLACP00000000710; ENSLACG00000000636. DR GeneTree; ENSGT00740000114936; -. DR OMA; EREACPR; -. DR OrthoDB; EOG09371V7T; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 184 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003578959. FT DOMAIN 11 180 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 184 AA; 21843 MW; 2633073960784832 CRC64; LLLIYLLFLP GSHYLHFFFT GIEGGQTFPE FIVVVMFDGA QIGYYDSTDE KVISKVEWLK EDTDPDWSEY IRRSRRSQQN FKYNMKILMQ RANHTESVHV YQRMIGCGTD NNGKTRGFDQ FGYNGEDYLM FETENVRWIA ASHFAVLQQD KWNSDRAGRQ DSKDFIDHVC TRWLKKFIIY QEKS // ID H2ZVF6_LATCH Unreviewed; 226 AA. AC H2ZVF6; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000001377}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000001377, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000001377} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000001377}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000001377} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01265392; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2ZVF6; -. DR Ensembl; ENSLACT00000001389; ENSLACP00000001377; ENSLACG00000001235. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2ZVF6; -. DR OMA; GCEMNEN; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 196 220 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 96 183 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 226 AA; 25227 MW; C35D88DA230A8FC8 CRC64; AGVHVYQKMV GCEMNENRLT RGFQQYGYDG DDFLVFDLEN LQWVAASQLS VPTKDRWNSN RASCSRCKQF VDQVCLHWLK NFVSYREKSS TPKTPPEVRI IPRKSDDGGT LTLSCMVTGF YPRAVDVNWI KNGETALNDT ISNETLPNED RTFQIKKSIE IHSADTNTYS CLVDHSSLNT NLNVPYDPKA NGNPTVISGI IIGVGIVGIL IVAIAGFLVW KYKGKG // ID H2ZYG3_LATCH Unreviewed; 342 AA. AC H2ZYG3; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000002434}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002434, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000002434} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000002434}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000002434} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01257432; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H2ZYG3; -. DR Ensembl; ENSLACT00000002454; ENSLACP00000002434; ENSLACG00000002173. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H2ZYG3; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 311 337 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 342 AA; 39337 MW; 7A5AD900797CE5AB CRC64; LLNMSLKNSE RNVHKIPDYI LSQWVGAVLP GSHYLHFFLT GIEGDQTFPE FIVVAMFDGA QIGYYDSTYK KLISKVEWLK EDKDPHWSEY IAYSVEQQQS FKYNMKILMQ RANHTVCVHV YQRMVGCKTD ANGKMRALDQ FGYNGEDYLV FETENVRWIA ASHLAVLQKD RWNFNRAGRQ DSNDFLDFVC FRWLKKFIIY QEKSSISQIP PEVRIIPRKS DDGETLTLSC MVTGFYPRDV DVNWIKNGET TLYDTQFSGI LPNEGRTFQV RKSIEIHPAD ANTYSCQVEH SSLNMTLNVP YDPRANGNPT VIPGIIIGVG IIGILIVTIA GFLVWTYKRK GK // ID H3A257_LATCH Unreviewed; 335 AA. AC H3A257; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000003728}; GN Name=LOC102348044 {ECO:0000313|Ensembl:ENSLACP00000003728}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000003728, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000003728} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000003728}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000003728} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01253572; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H3A257; -. DR STRING; 7897.ENSLACP00000003728; -. DR Ensembl; ENSLACT00000003762; ENSLACP00000003728; ENSLACG00000003320. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3A257; -. DR OMA; NTRICKA; -. DR OrthoDB; EOG091G0BU8; -. DR TreeFam; TF352056; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 295 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 194 280 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 335 AA; 38153 MW; FA31EE7EBE9FBEC9 CRC64; CGMFSLSSAG SRSHRYLETG TVGLPNRPDF MVVGYVDEVL FGDYDSWSGK VVLKQPWIEE YSQAEDPKYL ERMTLVAKEH HAGFKANIQI IKQRYNQTSG VHTLQNRYGC ELRDDATTDG FVHFGYDGED FISFDKEKLT WVAAVDQAIP TRDQWNADIP FTQGTRSFLE GECIELLKKF IRYGNKTLER KVRPEVTVYD KPGSESKSIS LTCMATGFHP RSIDVSWVRD ENTQMNDAYT DGILPNEDGT FQIKTTLQID SEDKRSYACH VDHSSLDEIM KVPWSKLLRR LSNGLAPWII IIIVIVVVVV AVLVAAVIGF VTWRRKKRGK KKQQP // ID H3A272_LATCH Unreviewed; 295 AA. AC H3A272; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000003743}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000003743, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000003743} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000003743}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000003743} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01255762; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H3A272; -. DR STRING; 7897.ENSLACP00000003743; -. DR Ensembl; ENSLACT00000003777; ENSLACP00000003743; ENSLACG00000003335. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3A272; -. DR OMA; WKGILER; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 295 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003578916. FT DOMAIN 206 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 295 AA; 33942 MW; 4ECFF15AD8EC8550 CRC64; MTKKMLLLIL VGCLYAEVRG GSHSLRYFYT GTSGLPDFPE FVIVGYVDEA QIMKYDSKSG RAVPKQSWME EYVRKEDLGY WERQTQISQG QQVLFKGDIQ TTMQRYNQTS GGVHTLQEMY GCELRDDGTT AGFEQFAYDG QDFVAFDKET QTWVTPVLAA VITKHKWDAD RASNQMLKGY LEQECVEWLI KYMCYRKEML ERKVRPEVRI YDGPGSESNS IALTCMVTGF YPRAIDVTWI RDGETQMDNT YTDGILPNED GMYQIEKIEI GSDDKCNHTC EVDHGSLNLE LNIVW // ID H3A2S0_LATCH Unreviewed; 354 AA. AC H3A2S0; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000003941}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000003941, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000003941} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000003941}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000003941} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01257433; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H3A2S0; -. DR Ensembl; ENSLACT00000003977; ENSLACP00000003941; ENSLACG00000003508. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3A2S0; -. DR OMA; TENARWI; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 299 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 354 AA; 40512 MW; 14B43ADD67CCF32D CRC64; HFGVLEVESQ VIYLLFLPGS HYLHFFLTGI KGDQTFPEFL IVAMFDGAQI AYYDSTDEKV ISKVEWLKED TDPDWSEYIR RSRISQQNFK YNMKILMQRA NHTESVHVYQ FMFGCETNNN GKTRGFDQFG YNGEDYLVFE TENARWIAAS QFAVFIQDRL NLNRAGRQDS KDFIDHVCTR WLKKFIIYQE KSSISQIPPE VRIIPRKSDD DETLTLSCMI TGFYPRDVDV NWVKNGETTL YDTQSSGILP NEDRTFQIQK SIEVHPADTN TYSCQVEHSG LNMTLNVPYD PRTNGNPTVI PGIITGVAIV GILIVTIAGF LVWKYKGKGK SGGKLKINSD VPSRMNNSCS EKQP // ID H3A5K4_LATCH Unreviewed; 350 AA. AC H3A5K4; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 20-JUN-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000004925}; GN Name=LOC102348567 {ECO:0000313|Ensembl:ENSLACP00000004925}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000004925, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000004925} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000004925}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000004925} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01253576; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 7897.ENSLACP00000004925; -. DR Ensembl; ENSLACT00000004968; ENSLACP00000004925; ENSLACG00000004379. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3A5K4; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G0BU8; -. DR TreeFam; TF352056; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 315 342 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 219 305 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 350 AA; 40315 MW; CC3F61DEB1C3BEEF CRC64; IISLLFFPAE SALLCNLHTL QEILSLSLSQ SRRSESLRYF YTAARTVGLP DLPEFMAVGY MDEVLLGEYN SWSGKAVSRQ HWMQEYSQAE EPQFWERMTQ LAKEHQASFK VNIQILMHIY NQTSGVHTYQ RRYGCELRDD ATTGGFDQFG YDGEDFISFD KEKLIWVAAV DQAIPSQDNW NANTAFIQGT KTYLEEECIE FLKKLIRYGN KTLERKVCPE VTVYDRPDFE SESIILTCMA TGFHPRSIDV SWVRDENTQM NDVYTDGILP NEDGTFQIKM TLQIDLKDKR SYACHVDHSS LEEIMKVPWV LSNVLATWII IVIVIVVVGT VLVAAVVGFV IWRRKKRGKK // ID H3A6H0_LATCH Unreviewed; 357 AA. AC H3A6H0; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000005241}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000005241, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000005241} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000005241}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000005241} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01181860; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01181861; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01181862; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01181863; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01181864; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01181865; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H3A6H0; -. DR STRING; 7897.ENSLACP00000005241; -. DR Ensembl; ENSLACT00000005288; ENSLACP00000005241; ENSLACG00000004656. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3A6H0; -. DR OMA; GINDRTE; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 300 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 204 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 357 AA; 40337 MW; BB29F761A0BA7930 CRC64; LIFTVIIIII IIIINGSPAG LHSLLHFYSG TEGLPGFPKF MAVGYVDGVQ IEYYDSWSEK VVPRQHWMEE YSQAEDPGYW EGRTQRLQQW RQTFKTRIHN YMQLYNQTSG VHTLQHICGC KLQGDATIDG VMKYGYDGED FISFDKEKLM WVAAVDQAIP TRNQWNADTA YIQALKAYFE GQCNELLSKF IHYGNKTLEQ KVRPEVTVYD KPGSESKSVS LTCMATGFHP RAVDVSWVRD GNTQMSNAYT AGILPNEDGT FQIKRTLQID SEDKRSYACH VDHSSLEEIM KVPWVPSNGL ATWIIIVIVI VVVVVAVLVA AVVGFLIWRI RRHGASNATS ARFLNSEARS RASNAMP // ID H3A9T7_LATCH Unreviewed; 358 AA. AC H3A9T7; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000006408}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000006408, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000006408} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000006408}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000006408} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01228263; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01228264; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01228265; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H3A9T7; -. DR Ensembl; ENSLACT00000006461; ENSLACP00000006408; ENSLACG00000005685. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3A9T7; -. DR OMA; QRVYGCD; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 303 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 203 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 358 AA; 40513 MW; DF6A04316CFB5742 CRC64; ISDRMEPLPL AAPITEVETG SHSWKAYLTF LKGDSRLPEF MAMHMVDDIQ IMYYDSEIGH CVTKQDWMET VNKEVSNYWN TQGDALRDRQ KNLKFMVKAL MNESNQSSGV HTFQNLYGCT LNDDDTTTGF WNSGYDGDDF SNFDTRGMTL SPGQGKSRMV EKFCSVDQKN VPHTKVYLEQ ECIEWLRNFL RYGKQKLERK VRPKVVVYDR LASESNSIVL TCLATGFYPR AIDVSWVRDG ETQMDSAATE GILPNEDETY QIRKRLEIGS EDKHNYTCRV EHSSTELPQI VAWAPSPGLK DGILVPVLVV SVLVLVLVLL LSVTGFVVWK KKKPGIKESG YNQAQQNESG DSSSNTSS // ID H3AB59_LATCH Unreviewed; 212 AA. AC H3AB59; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000006880}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000006880, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000006880} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000006880}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000006880} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01181869; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H3AB59; -. DR Ensembl; ENSLACT00000006939; ENSLACP00000006880; ENSLACG00000006106. DR eggNOG; ENOG410JP0A; Eukaryota. DR eggNOG; ENOG410ZMMY; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; LANRIMF; -. DR OrthoDB; EOG091G1N7D; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}. FT DOMAIN 96 183 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 212 AA; 23790 MW; 4BFE567D461E85B2 CRC64; TGVNIYQRRS GCEMDADGNK TRGFNVHSYN GKDYIEFDTE TQKWKASSEF AETQEEDNNK NTALFRQKCQ SLPKCASRSS STICMLANRI MFLVPPEVRV VDKKSDNGET LTLSCMVTGF YPRAVDVNWI KNGETTLTDV QSSGILPNED RTFQIQKSIE IYPADNNIYS CQVEHSSLNT ALNVPYDPRA NYNLKVILGI TTPLGILVIV LV // ID H3ACA4_LATCH Unreviewed; 156 AA. AC H3ACA4; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000007275}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000007275, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000007275} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000007275}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000007275} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01228267; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H3ACA4; -. DR Ensembl; ENSLACT00000007335; ENSLACP00000007275; ENSLACG00000006454. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3ACA4; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}. FT DOMAIN 80 156 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 156 AA; 18453 MW; A725EC7FDF851452 CRC64; DDETTTVFCK TSFQGEDFSS FDADRNLFTP ATGKAQIRSK IFPRKIRDSY FNEVWKQDCI EWLKKHLLYG KETLERKVAP EVRVYDRPDL ERNLITLTCM ATGFYPRAVD MTWVRDGKTQ MHNAHTDGIL PNEDETYQIR KTIEINPEDK RNYTCW // ID H3AE78_LATCH Unreviewed; 157 AA. AC H3AE78; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000007949}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000007949, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000007949} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000007949}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000007949} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01228271; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H3AE78; -. DR Ensembl; ENSLACT00000008015; ENSLACP00000007949; ENSLACG00000007036. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3AE78; -. DR OMA; IYHISSC; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}. FT DOMAIN 81 157 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 157 AA; 18437 MW; C337528BA03BD4CC CRC64; DDRTTAAFWK NSFHGEDFGS FDREQGLFTA VAEKAQIREK VCNIHKSWGN YIKDYLEKEC IEWLKKHILY GKEILEQKVA PEVRVYNRPG SERNSVALTC MATGFYPRTI DMTWVRDGET QMDDAHTDGI LPNEDETYQM RKTIEIDLED KHSYTCW // ID H3AEN8_LATCH Unreviewed; 280 AA. AC H3AEN8; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000008109}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000008109, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000008109} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000008109}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000008109} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01181874; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H3AEN8; -. DR Ensembl; ENSLACT00000008175; ENSLACP00000008109; ENSLACG00000007179. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3AEN8; -. DR OMA; FIEIHAS; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 15 {ECO:0000256|SAM:SignalP}. FT CHAIN 16 280 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012203935. FT DOMAIN 192 279 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 280 AA; 32007 MW; 92DE61461BFA55D5 CRC64; IKWTILIFLL PGKHSLHYIC TGIAGDPTFP EFILVVVLDG TQIGYYDSNT KTTVSKLDGL NKQTDLDWDV YISYATQQQA TFPLKLNKIM KRANHTAGFH IYQRLVGCEL DANGNMRGFN QHGYDGEDIL SFDKDNLQWT AASQVAVITK DTWNMNHEDC RDTKYFLEET CIRWLKKYVK HQEKISKGKI PPQVSIHARK SENSETLTLT CIATGFYPCD IEVNWIKNGE TILYDTLSSG VLPNEDRTFQ IQKFIEIHAS DTNTYSCQVE HSSLNTTLTY // ID H3AFD9_LATCH Unreviewed; 338 AA. AC H3AFD9; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 20-JUN-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000008360}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000008360, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000008360} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000008360}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000008360} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01228272; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01228273; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H3AFD9; -. DR Ensembl; ENSLACT00000008428; ENSLACP00000008360; ENSLACG00000007402. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3AFD9; -. DR OMA; DEGHEYT; -. DR OrthoDB; EOG091G0M1Y; -. DR TreeFam; TF352056; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 285 308 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 185 272 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 338 AA; 38882 MW; 26CED44C3EC310AF CRC64; GHVWKEYITF TEGTDGHLNM VAVDMVNDIQ TAYYDNTIRR YVLKHPCMEE LARVEDPDSW ARKATEFLLR KEQHNKGVIG RLKKETNHSS GVFVYQQMHG CELNDDETTT VFWKTSFQGE DFSSFDKDKE LFTPAAGKAQ IRSKVCRVTK AWINYISEDW KQECIEGLKK HLLYGKETLE RKVAPEVRVY DRPDSERNLI MLTCMATGFY PRAVDMTWVR DGKTKMDNAH TDGILPNEDE THQIRKTIEI DPEDKRNYTC WVDHSSLEKQ LSITWAPSPG VKSGITVPVV VVILVLILVL LITGFVIWRK KKPGVKKSDY TPAQRREAED SSSNTSSN // ID H3AG77_LATCH Unreviewed; 182 AA. AC H3AG77; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 20-JUN-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000008648}; GN Name=LOC102350052 {ECO:0000313|Ensembl:ENSLACP00000008648}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000008648, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000008648} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000008648}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000008648} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01221694; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01221695; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSLACT00000008716; ENSLACP00000008648; ENSLACG00000007644. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G0M1Y; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}. FT DOMAIN 10 179 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 182 AA; 21126 MW; 6F4E3F5BFA454DD5 CRC64; GHIWKEYITF TKETDGHLKI MAVDMVDDVQ TAYYDDMISR HVLKQPWMEE LGRVEDPNSW ASKATEFLLG NKEFNKGVIG RLKKETNHSS GVFIYQQMHG CELNDDETTT VLWKTSFQGE DFSSFDGDRN LYTPAAGKAQ IRSKVCPVDE AWDSYFSEDW KQECIEGLKK YLLYGKETLE RK // ID H3AH48_LATCH Unreviewed; 375 AA. AC H3AH48; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000008969}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000008969, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000008969} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000008969}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000008969} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01221696; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01221697; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01221698; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01221699; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01221700; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H3AH48; -. DR Ensembl; ENSLACT00000009038; ENSLACP00000008969; ENSLACG00000007920. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3AH48; -. DR OMA; WMEREGR; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 375 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003580308. FT TRANSMEM 320 343 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 375 AA; 42916 MW; 71E64BD1DF06A8F7 CRC64; SLACVCVCVC VCVCHLKVSV PRGGHVWKEY VTFTEGIDGH LNMVAVDMVD DVQTAYYDNT IRRYVLKHPW MEELGRVEDP DSWARKATEF LLSNEQRHKG VIDRLKKETD HSSGVFIYQQ MYGCELNDDE TTTMFRISSF QGEDFASFDR DRKLYTPATG KAQIMNKVCQ ATKAWTNYLS EGWKLECIEW LKKHLLYGKE TLERKVAPEV RVYDRPDLER NLIALTCMAT GFYPRDVDMT WVRDGETQMD NAHTDGILPN EDETYQIRKT IEIDLEDEHS YTCWVDHSSL EKQLSVTWGR YHRDPIVSVL NITPSSDFKV GIIVAVGVLA LILILVLIVI GFVKWKKEKK PGAACLGYTP AQREEAEDSS SNTSS // ID H3ALM2_LATCH Unreviewed; 342 AA. AC H3ALM2; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000010543}; GN Name=LOC102365873 {ECO:0000313|Ensembl:ENSLACP00000010543}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000010543, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000010543} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000010543}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000010543} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01201878; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSLACT00000010622; ENSLACP00000010543; ENSLACG00000009290. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 342 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003580388. FT TRANSMEM 302 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 342 AA; 39156 MW; 88AB402F2A84FE33 CRC64; MEMFLVFLLF SLFLPVNSEG NHYLHFYLTG VEGDQTFPEF LIVAMFDGAQ IGYYDSTYKK LISKVEWIKE DKDQDWNEYI AYSLRQQQSF EYNMKILMQR ANHTGIHVYQ EMVGCETDAN GKTRAFNQFG YNGEDYLVFE TENVRWIAAS HFAVLQQNRW NLNRAGHQYS KDFTDHVCAR WLKKFIIYQE KSSMSQIPPE VRIIPRKSDD GESLTLSCMV TGFYPHDVDV NWVKTGEITL YDTQSSGILP NEDRTFQLQK SIEIHPADTN TYSCQVEHSS LNMTLNVPYD PRANGDPTVN PGIIIGVGIV GILIVAIAGF LVWKYKGKGK IGGKVKKNCV GL // ID H3ALM3_LATCH Unreviewed; 353 AA. AC H3ALM3; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000010544}; GN Name=LOC102365873 {ECO:0000313|Ensembl:ENSLACP00000010544}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000010544, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000010544} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000010544}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000010544} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01201878; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H3ALM3; -. DR Ensembl; ENSLACT00000010623; ENSLACP00000010544; ENSLACG00000009290. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3ALM3; -. DR OMA; CLINTIE; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 353 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003579720. FT TRANSMEM 309 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 353 AA; 40477 MW; 47AFE0EB066E1C03 CRC64; LSENKEMEMF LVFLLFSLFL PVNSEGNHYL HFYLTGVEGD QTFPEFLIVA MFDGAQIGYY DSTYKKLISK VEWIKEDKDQ DWNEYIAYSL RQQQSFEYNM KILMQRANHT VCIHVYQEMV GCETDANGKT RAFNQFGYNG EDYLVFETEN VRWIAASHFA VLQQNRWNLN RAGHQYSKDF TDHVCARWLK KFIIYQEKSS MSQIPPEVRI IPRKSDDGES LTLSCMVTGF YPHDVDVNWV KTGEITLYDT QSSGILPNED RTFQLQKSIE IHPADTNTYS CQVEHSSLNM TLNVPYDPRA NGDPTVNPGI IIGVGIVGIL IVAIAGFLVW KYKGKGKIGG KDNSDVPSRM NNS // ID H3ANY8_LATCH Unreviewed; 338 AA. AC H3ANY8; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000011359}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000011359, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000011359} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000011359}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000011359} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01065260; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H3ANY8; -. DR Ensembl; ENSLACT00000011445; ENSLACP00000011359; ENSLACG00000009994. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3ANY8; -. DR OMA; AYLEENC; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 285 306 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 187 273 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 338 AA; 38326 MW; CD513D4FDEADBD00 CRC64; FSGTHIYRIT KTLISDGIET PHYIAVGILD DVQVTYYDSH LQQYIPKQKF MLDTEAGDRG FWTQASKKCT LRKQIYTEQL KMLIKRSNRT ASGDHILQVQ NGCEIDDQGN KRGFQSYAFD GVDFMSFDQK NNKWLAAVPE AMLTAQSLNL NKEFSSDRQD YLSYRCFNLL EKHYSLGKET FEKKVPPKVS VHRGKYADKA HTLSCVVTGF YPRAIDVMWL QDGNIVHAEL QSTGILPNHD ETYQIRKIIE IDPSSSYNYS CQVEHASLKE ALTVQWGPKD QRFKILIPVC STVVVVVLIV TVAGLLRWKK RRSAGSGGAQ LSVQASQRRG SRYHASAG // ID H3AS74_LATCH Unreviewed; 428 AA. AC H3AS74; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000012495}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000012495, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000012495} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000012495}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000012495} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01115950; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 7897.ENSLACP00000012495; -. DR Ensembl; ENSLACT00000012588; ENSLACP00000012495; ENSLACG00000011010. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3AS74; -. DR OMA; TCVEWLC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 428 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003580540. FT TRANSMEM 301 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 203 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 82 102 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 428 AA; 48334 MW; 01A9664E50DD8D83 CRC64; MLFVLLLSVL CALGVGAEPH TLRYLYLGTM NVKDFPEFLT VGLVDNVRIR YFDSVTGHCL SSQKWMEAFV EKEDPEYWES MNRRLKSRHQ NFKENIQILR RRYNQTNGAH SLQWTHGCTL GETGESVSGF MRFGYDGEDF ISFNMEGLNW VAAKQEAKIT KDKWDKDQAL NHQTKGYLQD ECIHWLKKYL EYGNGDLGRK VHPEVQIYNR PGPWKNSISL TCMVTGFYPQ SISVNWIKNG EVFQVSSSDN VLPNEDETYQ LRNTIEIDPE DEGSYACHVE HSSLEEKRIV SWEKETGLNT GIIVAVVIVV LLLVLAGVGF MIWKKVSPLF NRGAAQGPRP HIYRLPSPQS SVVVPVTDPS EQATETYTLL TENNEESHSD SGKGFSKGSI GDSGKGSISG SSKVSMESLI AEGKKFRINL PFVSTLRK // ID H3ATD5_LATCH Unreviewed; 359 AA. AC H3ATD5; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000012906}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000012906, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000012906} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000012906}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000012906} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01115954; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01115955; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H3ATD5; -. DR STRING; 7897.ENSLACP00000012906; -. DR Ensembl; ENSLACT00000013000; ENSLACP00000012906; ENSLACG00000011364. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3ATD5; -. DR OMA; RITQRFY; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 359 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003579892. FT TRANSMEM 303 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 40634 MW; B456ECA4C9730F82 CRC64; LFKALCKLVL CLHIHTFSMT GSHSLQYFYT STEGAEGFPE FEMVGFVDDV QIVYFDSQEG KANHKQQWLE KIVRDEDPSY WERITQTLSG DENMYKTSVT NVMKRFNQNS GVHTLQEMYG CELRDDGTTG GFDEFAYDGQ DFISFDKETQ TWTTPVQQAV ITKHKWDANR ASNQILKGYL EQECIEWLKK YIHYGKEMLE RKVQPQVKLS HRPGSERNSI VLTCMVTGFH PRAIDVTWIR DGETQMDNAH TDGILPNEDG TYQIKKTIEI GSDDKSRYAC EVEHGSLNPK LNVVWVPPSG SNMVIIIAVV IVVLVLVAAA IVGFVMWKNN PDGSDVGYSQ AQTKESSSDT SSDTTPPKV // ID H3AWB8_LATCH Unreviewed; 294 AA. AC H3AWB8; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000013939}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000013939, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000013939} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000013939}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000013939} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01115965; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01115966; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01115967; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H3AWB8; -. DR STRING; 7897.ENSLACP00000013939; -. DR Ensembl; ENSLACT00000014038; ENSLACP00000013939; ENSLACG00000012273. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3AWB8; -. DR OMA; GYVDSHP; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}. FT DOMAIN 208 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 294 AA; 33815 MW; 2141A66B6B16818F CRC64; EGHGSRGFVL IILRDYILSL SPAGSHSLRY FYTGTNGLPG LPEFVIVGYV DEVQIMQYDS ESRRAVSRQR WMDEITQEDP QYWERNRQIA QATQPIFKVG VQIALQRFNQ TSGGVHTLQE MYGCELRDDG TTGGFEQFAY DGQDFIAFDK ETQTWIAAVQ QAVITKHKWE ADQAFNHGLK GYLEQECIEW LKKYMRYGKE MLERKVRPEV RIYDRPGSEK NSIALTCIVT GFHPRAIDVA WIRDGDTRMD NAHTDGILPN EDGTYQIKKT IEIGSDDKHM YACEVEHSSL EQKL // ID H3B0A0_LATCH Unreviewed; 280 AA. AC H3B0A0; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000015321}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000015321, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000015321} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000015321}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000015321} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01115993; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01115994; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01115995; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01115996; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01115997; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01115998; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01115999; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H3B0A0; -. DR STRING; 7897.ENSLACP00000015321; -. DR Ensembl; ENSLACT00000015427; ENSLACP00000015321; ENSLACG00000013487. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3B0A0; -. DR OMA; YLEGICI; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 280 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003580027. FT TRANSMEM 223 247 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 116 203 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 280 AA; 31384 MW; 44BCEDBF92E25AF9 CRC64; MIKKLLLVFL LGVLYSAGVF AGIHTVQRMY GCELQEDGTT KGFFQDAYDG QDFISFDKET QTWTAPVQQA VITKQKWDAE RAMNQQWKGY LEGICIEWLK KYLRYGKETL ERKVRPQVKL SDRPGSEKNS IVLTCMVTGF HPRAIDVTWI RDGETRMDNA HTDGILPNED GTYQIKKTIE IGSDDKRSYA CEVDHGSLNP KLNVVWDPEE QTYSEAPPSG SNMVIIIAVV IVVLVLVAAA IVGFVMWKSE QGGSWKVGYS QAQTKESSSD TSSDTTPPKV // ID H3BJA9_MOUSE Unreviewed; 318 AA. AC H3BJA9; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 12-SEP-2018, entry version 42. DE SubName: Full=Histocompatibility 2, M region locus 5 {ECO:0000313|Ensembl:ENSMUSP00000134912}; DE Flags: Fragment; GN Name=H2-M5 {ECO:0000313|Ensembl:ENSMUSP00000134912, GN ECO:0000313|MGI:MGI:95917}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000134912, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000134912, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134912, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000134912} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134912}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR956641; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR MaxQB; H3BJA9; -. DR PRIDE; H3BJA9; -. DR Ensembl; ENSMUST00000176712; ENSMUSP00000134912; ENSMUSG00000024459. DR UCSC; uc012ata.1; mouse. DR MGI; MGI:95917; H2-M5. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000024459; Expressed in 21 organ(s), highest expression level in bone marrow. DR ExpressionAtlas; H3BJA9; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 278 301 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 180 268 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMUSP00000134912}. SQ SEQUENCE 318 AA; 36404 MW; ED8ED1CD26DDAC33 CRC64; XFFATTMTQP GLREHSFIFV VFVDDTQFLC YNNKGKNQRM EPRALWVKQM GPEYWEQQTR TVKVIEKIAL VNLQEAMDIY NHSKDGSHVF QCVYGCEVGP DGLFLRGHEK HAYDGRDYLT LSPDLHSWVA GDTAAQITLR RWEKSGVSEQ RQSFLKGECV ESLRTYLEIG KETLLRTDPP KAHVTHHPRP EGEVTLRCWA LGFYPANIIL TWQWDEEDLT QDMDLIETRP AGDGTFQKWA SVVVPSGEEQ RYTCHVQHEG LTQPLVLKWD PSKHTIPIMG ITVGLLLFGV VFTGAVVAIV MRKRKAHLET SDKYLTLT // ID H3BK58_MOUSE Unreviewed; 327 AA. AC H3BK58; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 12-SEP-2018, entry version 41. DE SubName: Full=Histocompatibility 2, M region locus 5 {ECO:0000313|Ensembl:ENSMUSP00000135262}; DE Flags: Fragment; GN Name=H2-M5 {ECO:0000313|Ensembl:ENSMUSP00000135262, GN ECO:0000313|MGI:MGI:95917}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000135262, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000135262, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000135262, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000135262} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000135262}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR956641; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR MaxQB; H3BK58; -. DR PRIDE; H3BK58; -. DR Ensembl; ENSMUST00000176784; ENSMUSP00000135262; ENSMUSG00000024459. DR MGI; MGI:95917; H2-M5. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000024459; Expressed in 21 organ(s), highest expression level in bone marrow. DR ExpressionAtlas; H3BK58; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 278 300 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 180 268 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMUSP00000135262}. SQ SEQUENCE 327 AA; 37369 MW; F3922763004750F2 CRC64; XFFATTMTQP GLREHSFIFV VFVDDTQFLC YNNKGKNQRM EPRALWVKQM GPEYWEQQTR TVKVIEKIAL VNLQEAMDIY NHSKDGSHVF QCVYGCEVGP DGLFLRGHEK HAYDGRDYLT LSPDLHSWVA GDTAAQITLR RWEKSGVSEQ RQSFLKGECV ESLRTYLEIG KETLLRTDPP KAHVTHHPRP EGEVTLRCWA LGFYPANIIL TWQWDEEDLT QDMDLIETRP AGDGTFQKWA SVVVPSGEEQ RYTCHVQHEG LTQPLVLKWD PSKHTIPIMG ITVGLLLFGV VFTGAVVAIV MRKRKGYCVL TLSKAHLETS DKYLTLT // ID H3BWB1_TETNG Unreviewed; 370 AA. AC H3BWB1; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 20-JUN-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTNIP00000000273}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000000273, ECO:0000313|Proteomes:UP000007303}; RN [1] {ECO:0000313|Ensembl:ENSTNIP00000000273} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|Ensembl:ENSTNIP00000000273} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H3BWB1; -. DR STRING; 99883.ENSTNIP00000000273; -. DR Ensembl; ENSTNIT00000003613; ENSTNIP00000000273; ENSTNIG00000005106. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3BWB1; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 370 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003580333. FT TRANSMEM 323 343 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 370 AA; 41555 MW; CBD34BFF61C00F13 CRC64; MNSLVFLLLL ALKSVPNCFA VTHTLNYFHT VSSGVPNFPE FVAVVMVDDV HISHYDSNTR RTQPRQEWME NVNADDPQYW EGETGNFMGA HQAYKARIEI LKPRFNQTGG VHTYQLMYGC EWDDETDEIN GFNQYGYDAE DFISFKLKEE IWVAAKREAE ITKRKCDQNR ANTDYLKSYY TQICIKWLQK FVDYGRSSLM RTELPSVSLL QKEPSSPVTC MATGFYPDGA TLSWRRGEEE LHEEVEPGEI LPNPDGTFQM SAALDLSSVP PEDWSSYKCV FQLSGGQEVP TSLDRKRIRT NRGKTGGGGD DAENPSNTSI TTAIVAVAVL VLVLGAIAGF LVYRQKVLAG KCPRAEGHPE VKEPLKPAPT // ID H3BX41_TETNG Unreviewed; 340 AA. AC H3BX41; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 20-JUN-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTNIP00000000554}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000000554, ECO:0000313|Proteomes:UP000007303}; RN [1] {ECO:0000313|Ensembl:ENSTNIP00000000554} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|Ensembl:ENSTNIP00000000554} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTNIT00000004097; ENSTNIP00000000554; ENSTNIG00000001085. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; GYVDSHP; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 311 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 38550 MW; 75C7F90B54C345B4 CRC64; MKIAKFVVVL AALAVYRSRA VIHTLKYFYY RSSGVPNFPE FSGAALLDGA EIVHYDSDTR RAEPRQEWME NLSAGDPQYW ERETAKFLGA QQTYNARIEI LKPRFNQTGA GVHIFQNMYG CEWDDETDER NGFDQWGYDG EDLMSFNLTE EIWVAAKREA EITTHTWNQD RAEMEYWKNY LTRECVSSLK TYLDYGRSSL MRTELPSVSL LQKEPSSPVT CMATGFYPGG ATLSWRRGEE ELHEEVEPGE ILPNPDGTFQ MSAALDLSSV PPEDWSSYKC VFQLSGGQEV PTSLDRKRIR TNWENPSITS ITSAIVGVAV LVLVLGAIAG FLVSRQRKGE // ID H3C1Q0_TETNG Unreviewed; 307 AA. AC H3C1Q0; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTNIP00000002167}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000002167, ECO:0000313|Proteomes:UP000007303}; RN [1] {ECO:0000313|Ensembl:ENSTNIP00000002167} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|Ensembl:ENSTNIP00000002167} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H3C1Q0; -. DR STRING; 99883.ENSTNIP00000002167; -. DR Ensembl; ENSTNIT00000003219; ENSTNIP00000002167; ENSTNIG00000001016. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3C1Q0; -. DR OMA; KTHITHY; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 276 298 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 177 268 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 129 149 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 307 AA; 34683 MW; D440FFB02AD0E831 CRC64; VTVSSGIPNL PEYVVVGMLD DVQTDHYDSI TGRAEPRQEW RKKVKAEHPE DWEGQTQIAA GIHQNFKATI EILKQRFNQT GAGVHIFQLM YGCEWDDETE ERNGFHQWGY DGEDFISFKL KEEIYVAAKR EAEVSARRWN QDRAEIEQQK NYYQTCIKWL KKYLDYGRSS LMRTEPPPLS VPSSRKEPSS PVTCVATGFY PGGATLSWRR GEEELHEEVE PGEILPNPDG TFQMSAALDL SSVPPEDWSS YKCVFQLSGG QEVPTSLDKN PSITTAIVGV GVAVLVLVLG AIAGFIMYRQ KKGESWR // ID H3C3X2_TETNG Unreviewed; 357 AA. AC H3C3X2; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 20-JUN-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTNIP00000002941}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000002941, ECO:0000313|Proteomes:UP000007303}; RN [1] {ECO:0000313|Ensembl:ENSTNIP00000002941} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|Ensembl:ENSTNIP00000002941} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTNIT00000001503; ENSTNIP00000002941; ENSTNIG00000001085. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3C3X2; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 312 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 357 AA; 40717 MW; 5F3A56132AE76904 CRC64; MKIAKFVVVL AALAVYRSRA VIHTLKYFYY RSSGVPNFPE FSGAALLDGA EIVHYDSDTR RAEPRQEWME NLSAGDPQYW ERETAKFLGA QQTYNARIEI LKPRFNQTGA GVHIFQNMYG CEWDDETDER NGFDQWGYDG EDLMSFNLTE EIWVAAKREA EITTHTWNQD RAEMEYWKNY LTRECVSSLK TYLDYGRSSL MRTELPSVSL LQKEPSSPVT CMATGFYPGG ATLSWRRGEE ELHEEVEPGE ILPNPDGTFQ MSAALDLSSV PPEDWSSYKC VFQLSGGQEV PTSLDRKRIR TNWENPSNTS TIVRVVISVL VLVLGTIAGF LVYRQKKGKC PRGRHHSGAE KKTNMQL // ID H3C426_TETNG Unreviewed; 357 AA. AC H3C426; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 20-JUN-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTNIP00000002995}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000002995, ECO:0000313|Proteomes:UP000007303}; RN [1] {ECO:0000313|Ensembl:ENSTNIP00000002995} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|Ensembl:ENSTNIP00000002995} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 99883.ENSTNIP00000002995; -. DR Ensembl; ENSTNIT00000000248; ENSTNIP00000002995; ENSTNIG00000001085. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 312 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 357 AA; 40597 MW; 19CD58AF3F10C538 CRC64; MKIAKFVVVL AALAVYRSRA VIHTLKYFYY RSSGVPNFPE FSGAALLDGA EIVHYDSDTR RAEPRQEWME NLSAGDPQYW ERETAKFLGA QQTYNARIEI LKPRFNQTGA GVHIFQNMYG CEWDDETDER NGFDQWGYDG EDLMSFNLTE EIWVAAKREA EITTHTWNQD RAEMEYWKNY LTRECVSSLK TYLDYGRSSL MRTELPSVSL LQKEPSSPVT CMATGFYPGG ATLSWRRGEE ELHEEVEPGE ILPNPDGTFQ MSAALDLSSV PPEDWSSYKC VFQLSGGQEV PTSLDRKRIR TNWENPSNTS TIVRVVISVL VLVLGTIAGF LVYRQKKGKC PRDTPASDLG VELKLES // ID H3C5B8_TETNG Unreviewed; 263 AA. AC H3C5B8; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTNIP00000003437}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000003437, ECO:0000313|Proteomes:UP000007303}; RN [1] {ECO:0000313|Ensembl:ENSTNIP00000003437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|Ensembl:ENSTNIP00000003437} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTNIT00000003521; ENSTNIP00000003437; ENSTNIG00000000474. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3C5B8; -. DR OMA; LANRIMF; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}. FT DOMAIN 139 227 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 263 AA; 29406 MW; 68D89080794C5AC2 CRC64; EGGGVGRIRA SLGEDGAHLS TGESAGTSLC FPHLCLCLCL SGVHVLQRMY GCEWDDETNE SLSGFYQYGY DGEDFISFNL TEEAWVAARR EAEVTKRRWE KHEGVKEHWK TYLTHRCISW VQEYVAYRQS SLVRTELPPS VSLLQKEPSS PVTCMATGFY PGATLSWRRG EEELHEEVEP GEILPNPDGT FQMSAALDLS SVPPEDWSSY KCVFQLSGGQ EVPTSLDRKR IRTNWGKTGG GGDDGEKNGL VLLWEQRLLL FSS // ID H3C7Z8_TETNG Unreviewed; 194 AA. AC H3C7Z8; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTNIP00000004370}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000004370, ECO:0000313|Proteomes:UP000007303}; RN [1] {ECO:0000313|Ensembl:ENSTNIP00000004370} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|Ensembl:ENSTNIP00000004370} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H3C7Z8; -. DR Ensembl; ENSTNIT00000004509; ENSTNIP00000004370; ENSTNIG00000001973. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3C7Z8; -. DR OMA; YLEGICI; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}. FT DOMAIN 95 189 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 194 AA; 22625 MW; D891AD08A1648079 CRC64; GVHIFQWMYG CEWDDEIDER NWFCQWGYDG EDFISFKLKE EIYVAAKREA EIITHRWNQN RALIEQQKYY YQICIKWLQK FVDYGRSSLM RTELPSVSLL QKEPSSPVTC MATGFYPGGA TLSWRRGEEE LHEEVEPGEI LPNPDGTFQM SAALDLSSVP PEDWSSYKCV FQLSGGQEVP TSLDRKRITT NWEG // ID H3CBH2_TETNG Unreviewed; 251 AA. AC H3CBH2; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTNIP00000005594}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000005594, ECO:0000313|Proteomes:UP000007303}; RN [1] {ECO:0000313|Ensembl:ENSTNIP00000005594} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|Ensembl:ENSTNIP00000005594} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H3CBH2; -. DR Ensembl; ENSTNIT00000005742; ENSTNIP00000005594; ENSTNIG00000003024. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3CBH2; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}. FT DOMAIN 199 251 IGc1. {ECO:0000259|SMART:SM00407}. SQ SEQUENCE 251 AA; 28628 MW; 572FD00818104AF3 CRC64; SLPVTHTLKY FYYRSSGVPN FPEFLAVVMV DDVQISHCDS NTRRAEPRQE WMEKVTADDP QYWERETAKF LDAQQTYNAR IEILKPSFNQ TGAGVHVYQS TYGCEWDDET KKINGFSQGG YDGEDLLRFK LKEAICAAAK PEAEILKRSG DEKKAEMESL KYYLTHECVY WLKKYLDYGR SSLMRTELPS VSLLQKEPSS PVTCMATGFY PGGATLSWRR GEEELHEEVE PGEILPNPDG TFQMSAALDL S // ID H3CCR3_TETNG Unreviewed; 333 AA. AC H3CCR3; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 20-JUN-2018, entry version 42. DE SubName: Full=Major histocompatibility complex class I ZJA {ECO:0000313|Ensembl:ENSTNIP00000006036}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000006036, ECO:0000313|Proteomes:UP000007303}; RN [1] {ECO:0000313|Ensembl:ENSTNIP00000006036} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|Ensembl:ENSTNIP00000006036} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 99883.ENSTNIP00000006036; -. DR Ensembl; ENSTNIT00000006184; ENSTNIP00000006036; ENSTNIG00000003449. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3CCR3; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G0BBK; -. DR TreeFam; TF334519; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 333 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003582163. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 333 AA; 37889 MW; 996EACA0B0DAC1C9 CRC64; KSFMVLLVLL GSGLVVDGGL SEIHSLHYIY TALSRPVNRP GIHEFTAMGM LDDHMIDYFD SDKQVKVPKQ TWMKTELEEN YWEKGTQSRK SKQQWFKVNI KILKDRFRQN DSDIHVLQWV HGCNIDTSGN ETEFLHGIDM YSYDGESFLT FDEANENWVA PNDAALQTKR KWDDLQVLKE YTKVYLKKEC VTWLERFLKY QKENTAPVKP AVYALSREAN VQANIVLTCM ATGFSSINTI VQIKRDGLVL TKDDGDVRPN GDGTYQKRDQ VEIPKSDKSK YTCEVIHESS GLHEIRVWDT DEGNTAVVVG AVVGVVVVVV LVIGIGLYMA VKK // ID H3CEU0_TETNG Unreviewed; 205 AA. AC H3CEU0; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTNIP00000006764}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000006764, ECO:0000313|Proteomes:UP000007303}; RN [1] {ECO:0000313|Ensembl:ENSTNIP00000006764} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|Ensembl:ENSTNIP00000006764} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H3CEU0; -. DR Ensembl; ENSTNIT00000006915; ENSTNIP00000006764; ENSTNIG00000004145. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3CEU0; -. DR OMA; VEHESLL; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}. FT DOMAIN 96 186 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 205 AA; 23412 MW; 87D3F9106FA92D77 CRC64; GVHTFQWMVG CEWDDETDEI NGFDQYGYDG DDFLSFKLKD GTWVAAKREA EITKRKWDYD GAGIDYWKYY HNQNCIKWLK KYLDYGRSSL MRTELPHSVS LLQKEPSSPV ICMATVFYPD GATLSWRRGE EELHEEVEPG EILPNPDGTF QMSAALDLSS VPPEDWSSYK CVFQLSGGQE VHTSLDRKQI RTNWGKTGGG GDDGE // ID H3CHP6_TETNG Unreviewed; 366 AA. AC H3CHP6; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 20-JUN-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTNIP00000007774}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000007774, ECO:0000313|Proteomes:UP000007303}; RN [1] {ECO:0000313|Ensembl:ENSTNIP00000007774} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|Ensembl:ENSTNIP00000007774} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSTNIT00000007935; ENSTNIP00000007774; ENSTNIG00000005106. DR GeneTree; ENSGT00740000114936; -. DR OMA; VTHHPVF; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003581275. FT TRANSMEM 320 342 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 41454 MW; 67D7A6E3B125AC37 CRC64; MNSLVFLLLL ALKSVPNCFA VTHTLNYFHT VSSGVPNFPE FVAVVMVDDV HISHYDSNTR RTQPRQEWME NVNADDPQYW EGETGNFMGA HQAYKARIEI LKPRFNQTGA GVHTYQLMYG CEWDDETDEI NGFNQYGYDA EDFISFKLKE EIWVAAKREA EITKRKCDQN RANTDYLKSY YTQICIKWLQ KFVDYGRSSL MRTELPSVSL LQKEPSSPVT CMATGFYPDG ATLSWRRGEE ELHEEVEPGE ILPNPDGTFQ MSAALDLSSV PPEDWSSYKC VFQLSGGQEV PTSLDRKRNR TNWEVWVVFS PPENPSITTA IVGVAVAVLV LVLGAIAGFI VYRQKKGKCP RAEGHPEVKE PLKPAA // ID H3CXA2_TETNG Unreviewed; 323 AA. AC H3CXA2; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTNIP00000012887}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000012887, ECO:0000313|Proteomes:UP000007303}; RN [1] {ECO:0000313|Ensembl:ENSTNIP00000012887} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|Ensembl:ENSTNIP00000012887} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H3CXA2; -. DR STRING; 99883.ENSTNIP00000012887; -. DR Ensembl; ENSTNIT00000013079; ENSTNIP00000012887; ENSTNIG00000009992. DR eggNOG; ENOG410KF51; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H3CXA2; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 323 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003581746. FT DOMAIN 204 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 323 AA; 37477 MW; 0BDF2E20E596C2AD CRC64; MFYTCIFICL FSVTDHLFAE KHYLKYYLTA SSGVTNQPEF VAQLVVDNLP GGYCDSNGKI PQPRDDWAIK MIHEDPKQLE LYENECVRYQ HTYRGHIKNI KQQFNQSGGI HIFQRIHGCE WDDETGEVTA FNQFGYDGED FISLDPVTMT WVAAKPQALI TKYKWDSEII YLQIKKMFNS HLCPDRLKMY LQFLKRFQQK KVQPSVFLLQ KTPSSPVSCH VTGFHPENGV VFWRKDGQKL QEEVEYTEIL PNHDGTFQTR VDLELSSVSP EEWSRYECVF HPPGDQEDIT LKLDKDVIRT NWGKTGSACC VICQSETSLL KCV // ID H7BZJ8_HUMAN Unreviewed; 85 AA. AC H7BZJ8; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 12-SEP-2018, entry version 39. DE SubName: Full=Zinc-alpha-2-glycoprotein {ECO:0000313|Ensembl:ENSP00000389942}; DE Flags: Fragment; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSP00000389942}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000389942, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000389942, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., RA Waterston R.H., Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000389942} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC004522; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H7BZJ8; -. DR MaxQB; H7BZJ8; -. DR PeptideAtlas; H7BZJ8; -. DR PRIDE; H7BZJ8; -. DR Ensembl; ENST00000419575; ENSP00000389942; ENSG00000160862. DR UCSC; uc064fxu.1; human. DR EuPathDB; HostDB:ENSG00000160862.12; -. DR HGNC; HGNC:910; AZGP1. DR OpenTargets; ENSG00000160862; -. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR ChiTaRS; AZGP1; human. DR Proteomes; UP000005640; Chromosome 7. DR Bgee; ENSG00000160862; Expressed in 195 organ(s), highest expression level in minor salivary gland. DR ExpressionAtlas; H7BZJ8; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:H7BZJ8, KW ECO:0000213|PeptideAtlas:H7BZJ8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 2 50 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000389942}. SQ SEQUENCE 85 AA; 9709 MW; 445C67B8A51F0C72 CRC64; XTYIYTGLSK HVEDVPAFQA LGSLNDLQFF RYNSKDRKSQ PMGLWRQQKY PGPARSSLCG GHQPPGPRRK EETEVPGLRL LPREN // ID H9G3R8_ANOCA Unreviewed; 302 AA. AC H9G3R8; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 12-SEP-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000000429}; GN Name=LOC100555175 {ECO:0000313|Ensembl:ENSACAP00000000429}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000000429, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000000429} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000000429}; RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000000429} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9G3R8; -. DR Ensembl; ENSACAT00000000446; ENSACAP00000000429; ENSACAG00000000468. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9G3R8; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000000468; Expressed in 3 organ(s), highest expression level in kidney. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}. FT DOMAIN 201 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 302 AA; 35136 MW; 739D90AD8F23A7B7 CRC64; LVTHYRLSGR WETVWFSSTH NLYYSLTMWE HTGDPVHFVL HNYLDYESLY YYDNNIREVI PHATWINKAE KEYPGYWKQN QLGAASLERG LRADLLYLKN NINQTMSTLT WQMSFGCMLH PDNTTSSYYK TAYNGKDFLA FDTVKGSWTA LSVEGQNNKL EWDARNVTNK SFKTFLELGC IAWLKKYLEY LEGVSLKKNP PKARVTIRVK PDGEEVLTCR AYGFSPKEIS VNWVNDRDVI TAGVVYGNVT PNFDGTFYTW LRITVDPKER SNFQCRMEHE MLKKPIKVFL RKPGKGAVVG RV // ID H9G3Y5_ANOCA Unreviewed; 321 AA. AC H9G3Y5; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 12-SEP-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000000544}; GN Name=LOC100560414 {ECO:0000313|Ensembl:ENSACAP00000000544}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000000544, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000000544} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000000544}; RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000000544} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9G3Y5; -. DR STRING; 28377.ENSACAP00000000544; -. DR Ensembl; ENSACAT00000000563; ENSACAP00000000544; ENSACAG00000000562. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9G3Y5; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000000562; Expressed in 1 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 321 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003619649. FT DOMAIN 205 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 321 AA; 37373 MW; AFB135FAAC6096F1 CRC64; MGSLFLLGFI VLLAGSCSGC SSHSMLYFVT SVSEPGQQVP QFSYVGFVND QEFVFYNAST KRYLPKVPWI SQVEKDDPDY WERNTLYAQG HERSFRDHLA TLAKYYNQSG GLHTFQWMYG CELRNNWSKR GYYQYAYDGR DYISLDKKTL TWTAADVPAQ NTKRKWDANF RDNKFKKFYL EETCIKWLQR YLNYGKETLL RTEKPEVKVT RKVDYDGMET LICRVGGFYP KEIDITWTRD GEVWMQDTFH GLVSPNSDGT YYTWWNVTVD PKEKERYKCH VEHDGLLNPV DVAWEEPASK SVLIGCAVGI LLPIAGLAVY F // ID H9G723_ANOCA Unreviewed; 261 AA. AC H9G723; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 12-SEP-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000003009}; DE Flags: Fragment; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000003009, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000003009} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000003009} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9G723; -. DR STRING; 28377.ENSACAP00000003009; -. DR Ensembl; ENSACAT00000003086; ENSACAP00000003009; ENSACAG00000003088. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9G723; -. DR OMA; VEHESLL; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000003088; Expressed in 4 organ(s), highest expression level in kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 212 233 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 113 201 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSACAP00000003009}. SQ SEQUENCE 261 AA; 29915 MW; FD6B692675B413B1 CRC64; HFNLKTLTHT NRNSSVGMGF HTLQQMYGCD LRKDGSKAGY RQYAYDGKDF ISFDKETLTW TAADVEAQTT KRKWDAQYTR NQYLKAYLEA ECIGWLQKYL EYGKETLLRT ETPEVMVTRK VDHDGMETLI CRVGGFYPKE IDIEWTRDGE VWTQDVFHGL VSPNSDGTYY TWRSITVDPK ERERYQCHVE HDGLLKPVDV AWEEPASNLR RIIGCVVVAL VAIAAIAGLA VYFKKCQGDC KATSGGRRGL QNSNKKKNIK M // ID H9G890_ANOCA Unreviewed; 311 AA. AC H9G890; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 12-SEP-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000003807}; DE Flags: Fragment; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000003807, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000003807} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000003807} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9G890; -. DR Ensembl; ENSACAT00000003899; ENSACAP00000003807; ENSACAG00000003922. DR GeneTree; ENSGT00740000114936; -. DR OMA; CHIDHAS; -. DR OrthoDB; EOG091G0GOV; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000003922; Expressed in 4 organ(s), highest expression level in brain. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 263 287 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 167 253 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSACAP00000003807}. SQ SEQUENCE 311 AA; 35540 MW; E636931A55CCC7A4 CRC64; ASSHSLYYFR TYMSEAIPGA PRYVEIGYLD GQPIERYDSK SGKMHPLTPW ISHSVSLMEN YWEVQSSLAQ LNEEGFEHFT VILERYYNGY DVGLHTLQCV DGCELSDDGT EKLYHREAYD GKELTDWDIV WDIYRHRKGF WGQTCIGWLR RHLEFQKKNL PTDAEAPDVK LIHRPINGSL ETLICKVNGF FPKDINAFWL KDGKIVDDEN IHVKVVPNAD GTYQARLTIQ VDPTEAQHYE CHIDHASLNE PLHKGWRWSA DSAWPIVGSV AAAVAVGLVV VSGLIFYTSR VWRGAGASRS LSMGRIQRKH L // ID H9GBH1_ANOCA Unreviewed; 311 AA. AC H9GBH1; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 12-SEP-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000006333}; GN Name=LOC100552169 {ECO:0000313|Ensembl:ENSACAP00000006333}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000006333, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000006333} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000006333} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR RefSeq; XP_008122411.1; XM_008124204.2. DR ProteinModelPortal; H9GBH1; -. DR STRING; 28377.ENSACAP00000006333; -. DR Ensembl; ENSACAT00000006475; ENSACAP00000006333; ENSACAG00000006471. DR GeneID; 100552169; -. DR KEGG; acs:100552169; -. DR eggNOG; ENOG410KF51; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9GBH1; -. DR KO; K06751; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000006471; Expressed in 4 organ(s), highest expression level in kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 257 280 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 175 246 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 311 AA; 35983 MW; D0D4966676C9B89E CRC64; MAVVQVDGVT IGHYDSQVRR AIPRVPWITR VEEAYPMFWD WVTDRAQKAE MWFGWDMKKL QKLHNQSGGI YTLQSMYGCE MDGDGDRIQG YGLYGYNGED FLSFDIETRI WTVSDVRAET LKKRWDSNVD RSQKIKDYLE RNCIEYLQKF LDYGKEVLTI KEPPTVKVSY DGLKTLTCRV DGFYPKEIDA VWKKDSEVWE QETLRGGVVP NSDGTFHTWL RLEVDPKDRD LYRCHVDHAA LEEALDTAWE EPASIPIIII IIIIAVLSVL VAHAVLLLWY KRNELPKIIS KPFERQPLNT GGTKGQSQPD S // ID H9GBL3_ANOCA Unreviewed; 341 AA. AC H9GBL3; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 12-SEP-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000006420}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000006420, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000006420} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000006420} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9GBL3; -. DR STRING; 28377.ENSACAP00000006420; -. DR Ensembl; ENSACAT00000006565; ENSACAP00000006420; ENSACAG00000006498. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9GBL3; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000006498; Expressed in 4 organ(s), highest expression level in heart. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 341 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003619798. FT TRANSMEM 302 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 341 AA; 39266 MW; 512AD47CC60A22C1 CRC64; MSPVSGLFPL LLGAIVSPFG CSAHSGRSHR LHYFFTGVSE PGGGLPHFSI VGYLDDEQFV RYDSETRRDL PRSSWIRKME EHDAQYWDWQ TQLSRSWELY FRVSLWTRFN HSRGHHTWQW MHGCEVSADG RKGGLSQFGY DGRDFLSLDK ETLTWTASNP KAQVTKRKWE ADRVWTQGRK TFLEEDCIDW LHKYLNYGKE TLLRKESPVV KVTRKAGYGD LETLLCRAHG FYPKEIDITW RMEGNVMEQE TRRGGIAPNA DGTYHTWLSI EVDTKDRDLY RCHVEHDSLP EPLDAAWEEA GVLWPLVAGI SGAVAVVILL GVILVLYLKR RHEGYRATAS S // ID H9GBT0_ANOCA Unreviewed; 362 AA. AC H9GBT0; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 12-SEP-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000006547}; GN Name=LOC100559565 {ECO:0000313|Ensembl:ENSACAP00000006547}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000006547, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000006547} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000006547}; RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000006547} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9GBT0; -. DR STRING; 28377.ENSACAP00000006547; -. DR Ensembl; ENSACAT00000006692; ENSACAP00000006547; ENSACAG00000006674. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9GBT0; -. DR OMA; DWARYDC; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000006674; Expressed in 4 organ(s), highest expression level in heart. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 41313 MW; ED4C9BB63ADB23CA CRC64; SGTSKLPILG LPLEEDPLGG PSSSSSHSMC YFVTSISEPG QQVPQFFYVG YVDDQEFVSY NTGTRRYLAK VPWISQVEKN DPKYWERNTL YAQGHEQSFR DHLATLAEYY NQSGGLHTFQ WMYGCELRRD GSKGGYYQYA YDGRDYISLD KDTLTWMAAD VPAQNTKRKW EADFSDNKYK KIYLEETCIE WLQRYLNYGK KTLLRTEVPE VKVTRKEDYD GMETLICRVG GFYPKDIDID WTRDGEVWMQ DVFHGLVSPN SDGTYYTWRS VTVDPKERER YKCHVEHDGL PNPVDVAWEE PASNLGLIIG CVVGVLFLMA VMAGIAVYFS EKQDEKHHSG YKAAAASEQG SNSSGTGKCP QT // ID H9GQM1_ANOCA Unreviewed; 114 AA. AC H9GQM1; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 12-SEP-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000018273}; DE Flags: Fragment; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000018273, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000018273} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000018273} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9GQM1; -. DR Ensembl; ENSACAT00000028789; ENSACAP00000018273; ENSACAG00000025539. DR GeneTree; ENSGT00900000141162; -. DR InParanoid; H9GQM1; -. DR OMA; WDSETEI; -. DR OrthoDB; EOG091G0GOV; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000025539; Expressed in 4 organ(s), highest expression level in heart. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}. FT DOMAIN 25 113 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSACAP00000018273}. SQ SEQUENCE 114 AA; 13554 MW; BC590E4E644D880F CRC64; INLPRLGRNF LISYPFLQTC HSFSSHSLKY FYTAISEDNE LLSSFYVVGY MDDQRISQYD STVRLELPCV SWMKKVEEVD PSYWKDETEV SRNSEQFFKE NLVIARNRYN QSRG // ID H9GQP3_ANOCA Unreviewed; 202 AA. AC H9GQP3; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 12-SEP-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000018317}; GN Name=LOC100568154 {ECO:0000313|Ensembl:ENSACAP00000018317}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000018317, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000018317} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000018317}; RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000018317} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 28377.ENSACAP00000018317; -. DR Ensembl; ENSACAT00000025313; ENSACAP00000018317; ENSACAG00000024309. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9GQP3; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000024309; Expressed in 3 organ(s), highest expression level in kidney. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}. FT DOMAIN 108 196 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 202 AA; 23751 MW; 2A77B57547E79022 CRC64; PSLNLHHLCI SLSGFHTLQQ MYGCDLRKDG SKAGYRQYAY DGKDFISFDK ETLTWTAADV KAQFTKRKWD AQYTRNQYLK AYLEEECILW LKKYLEYGKE TLLRTETPEV MVTRKVDHDG METLICRVGG FYPKEIDIEW TRDGEVWTQD VFHGLVSPNS DGTYYTWRSI TVDPKERERY KCHVEHDGLL KPVDVAWEEP GM // ID H9GQU0_ANOCA Unreviewed; 346 AA. AC H9GQU0; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 12-SEP-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000018398}; GN Name=LOC100553015 {ECO:0000313|Ensembl:ENSACAP00000018398}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000018398, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000018398} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000018398}; RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000018398} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9GQU0; -. DR STRING; 28377.ENSACAP00000018398; -. DR Ensembl; ENSACAT00000024930; ENSACAP00000018398; ENSACAG00000024638. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9GQU0; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000024638; Expressed in 4 organ(s), highest expression level in heart. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 346 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003621068. FT TRANSMEM 301 325 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 346 AA; 40001 MW; A489F3459A44D39C CRC64; MGAFRGLFFF FLFFPGTLAG SFSHSMRGFY TATWDPSQAQ PQVAIVIYVD DQLATQYNSS TRQALPQVYW MEKMDEHIPS FWEVNTLKGQ RLELRLKKTL ENLKERSNQS TGFLTFQLMT GCEIRKNGHK EGYHQYSYNG RDFLSFDPKT QTWTAADLEA QITQRQWDGD VDYSRHVMYY VEEECPEDLQ RFVEYGKESL LRRETPVVTI SRKAYYDGLE TLLCRVHGFY PKEIDVNWKR DGEVWVQDTF SGGILPNADG TYHTWISIEV EPKERDRYRC HVEHDSLEEP LVLAWEDRGS VWPLVGGVLG AVVGVLLVAA GIILYKKKGQ EATEEEPQVE DPLMNG // ID H9GR22_ANOCA Unreviewed; 320 AA. AC H9GR22; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 12-SEP-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000018536}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000018536, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000018536} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000018536} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9GR22; -. DR STRING; 28377.ENSACAP00000018536; -. DR Ensembl; ENSACAT00000011953; ENSACAP00000018536; ENSACAG00000011968. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9GR22; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000011968; Expressed in 4 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 320 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003621479. FT DOMAIN 224 312 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 320 AA; 36788 MW; 1D675B933ADBA2E5 CRC64; MALPLWLLLG PACLSLFLLG DSVLALPKGT AEPEMAPGAS FHFLRFFYTG VTESSPGVPH FVIVGYVDDQ LFFQYDAQTR KAVPRVPWME KVGEADPQYW VEQTQVAQNA EVGFRVDLAN LRERYNQTGG FHTWQWMYGC ELRKDRSKGG YYQYAYDGRG SLSFDKKTLT WTAADVPAQI TKRRWEREKI QAQRFNHYLE GECIDWLQNY LDYGKQTLLR TERPVGRVSR TTASDGQEAL ICQAHGFHPR EIDATWRKGE ENMDHETLRR NIAPNSDGTY HTWLSIEIDP KEMDLLRCHL EHASLSTPMV LAYEEPGVNI // ID H9GR57_ANOCA Unreviewed; 360 AA. AC H9GR57; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 12-SEP-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000018603}; DE Flags: Fragment; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000018603, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000018603} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000018603} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9GR57; -. DR STRING; 28377.ENSACAP00000018603; -. DR Ensembl; ENSACAT00000022425; ENSACAP00000018603; ENSACAG00000023667. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9GR57; -. DR OMA; QPRFIAV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000023667; Expressed in 3 organ(s), highest expression level in kidney. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}. FT DOMAIN 210 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSACAP00000018603}. SQ SEQUENCE 360 AA; 42019 MW; 6A14DD9B239917EE CRC64; VGFPFAEPRL HINIICAFFL TSLAISSHSL RYFYTAASED NKWLSSFIIV GYVDDQQICQ YDSIMREKRP CVPWMSKVEE EDPSYWEEET EMSRNSEQFF KESLVTAKNR YNQSGGFHTL QQMYGCDLRK DGSKAGYRQY AYDGKDFISF DKETLTWTAA DVEAQFTKRK WDAQYTRNQY LKAYLEEECI LWLKKYLEYG KETLLRTEAP EVKVTRKEDY DGMETLICRV WGFYPKEIDI EWTRDGEVWM QDTFHGLVSP NSDGTYYTWR SVTVDPKERE RYTCHVEHDG LPSPVDMAWK EPDSASKSVL IGCSVGILLP ITGLGVYFQK HQDDYKTVSG SDKKFNSSKE GKSIQFVRQS // ID H9GRY4_ANOCA Unreviewed; 319 AA. AC H9GRY4; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 12-SEP-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000019090}; DE Flags: Fragment; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000019090, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000019090} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000019090} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9GRY4; -. DR STRING; 28377.ENSACAP00000019090; -. DR Ensembl; ENSACAT00000024765; ENSACAP00000019090; ENSACAG00000024528. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9GRY4; -. DR OMA; ESEHYKC; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000024528; Expressed in 4 organ(s), highest expression level in heart. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 319 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003621492. FT TRANSMEM 296 318 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 204 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSACAP00000019090}. SQ SEQUENCE 319 AA; 36528 MW; 93E0D3A0B77CA104 CRC64; LSRDGPFFLL LGVSALLLGG SAGSSSHSLR YFTTIVSEPG QEVPQFFSVG YVDDQEVTSY DAKARRDLPK APWMRKVDKW ERNSQVAWNW EQIFRVGLGT LLGYYNQSGG AHTLQWMYGC EMRKDRSKVG YFQYGYDGRD YLSLDKETLT WTAANVPAQN TKRKWEANHA FLQYSKDYLE KDCIEWLQRY LDYGKETLLR TEKPEVKVTR KEDYDGMETL TCHVGGFYPK DIDIDGEVWM QDVFHGLVSP NSDGTYYTWR SIKVDPKESE HYKCHMEHDG LPNPVDVAWE EPASNLGLII GCVLGIIFLI AVMAGIAVY // ID H9GSQ9_ANOCA Unreviewed; 338 AA. AC H9GSQ9; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 12-SEP-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000019604}; GN Name=LOC100565608 {ECO:0000313|Ensembl:ENSACAP00000019604}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000019604, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000019604} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000019604}; RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000019604} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9GSQ9; -. DR Ensembl; ENSACAT00000026277; ENSACAP00000019604; ENSACAG00000022657. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9GSQ9; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000022657; Expressed in 4 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 338 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003621503. FT TRANSMEM 312 336 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 216 304 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 338 AA; 38911 MW; B824C64743476DEC CRC64; MARLLLLRVV ALLLGHPGIA LLNPAPGVSS SSSHSLRYFY TAASEDNKMH SSFIIVGYVD DQRICQYDST VREKRPSVPW MSKVEEEDPS YWKDESEESR NAEVFFKESL VIARNRYNQS GGFHTLQQMY GCDLRKDGSK AGYRQYAYDG KDFISFDKET LTWTAADVEA QTTKRKWDAQ SMRNQYLKAY LEEECILWLQ KYLEYGKETL LRTEKPEVKV TRKVDYDGME TLICRVGGFY PKEIDITWTR DGEVWMQDTF HGLVSPNSDG TYYTWWNVTV DPKEKERYKC HVEHDGLLNP VDVAWEEPDS KFGLIIGCIV GALLAIAAIA GLAVYFRE // ID H9GT81_ANOCA Unreviewed; 115 AA. AC H9GT81; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 12-SEP-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000019917}; GN Name=LOC103282603 {ECO:0000313|Ensembl:ENSACAP00000019917}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000019917, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000019917} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000019917}; RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000019917} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9GT81; -. DR Ensembl; ENSACAT00000025186; ENSACAP00000019917; ENSACAG00000024939. DR GeneTree; ENSGT00900000141162; -. DR InParanoid; H9GT81; -. DR OMA; LEYWDRE; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000024939; Expressed in 3 organ(s), highest expression level in heart. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}. FT DOMAIN 26 113 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 115 AA; 13248 MW; 773F810380F96264 CRC64; FYLLALRDVL DLICTAVEIT TSGCSSHSML YFVTSVSEPG QQVPQFSYVG FVNDQEFVFY NASTKRYLPK VPWISQVEKD DPDYWERNTL YAQGHERSFR DHLATLAKYY NQSGG // ID H9GTB3_ANOCA Unreviewed; 356 AA. AC H9GTB3; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 12-SEP-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000019987}; GN Name=LOC100566979 {ECO:0000313|Ensembl:ENSACAP00000019987}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000019987, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000019987} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000019987}; RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000019987} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9GTB3; -. DR STRING; 28377.ENSACAP00000019987; -. DR Ensembl; ENSACAT00000023281; ENSACAP00000019987; ENSACAG00000027871. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9GTB3; -. DR OMA; SALTKTW; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000027871; Expressed in 4 organ(s), highest expression level in heart. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT DOMAIN 211 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 356 AA; 41182 MW; 9CA4A92F7C2C6A40 CRC64; FNLHSKVSLF LHILSPVFMP SSFSSSSSHS LRYFYTAASE DNKWLSSFII VGYVDDQRIC QYDSIVREKR PCVPWMSKVE EEDPSYWAEE TEVSRNSELF FKVSLVTANN RYNQSGGFHT LQQMYGCDLR KDGSKAGYRQ YAYDGKDFIS FDKETLTWTA ADVKAQITKR TWDAQSTRNQ YLKAYLEEEC IKWLQKYLEY GNETLLRTEK PEVKVTRKVD YDGMETLICR VGGFYPKDID IEWTRDGEVW MQDTFHGLVS PNSDGTYYTW RSITVDPKER ERYKCHVEHD GLPSPVDVAW EDPASKSVLI GCAVGILLPI TGLAVYFPEK HQDDYKTVSA SDQKFNISEV KNEVPL // ID H9GUX5_ANOCA Unreviewed; 189 AA. AC H9GUX5; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 12-SEP-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000020986}; DE Flags: Fragment; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000020986, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000020986} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000020986} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 28377.ENSACAP00000020986; -. DR Ensembl; ENSACAT00000026079; ENSACAP00000020986; ENSACAG00000024081. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9GUX5; -. DR OMA; KTHITHH; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000024081; Expressed in 4 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}. FT DOMAIN 108 189 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSACAP00000020986}. SQ SEQUENCE 189 AA; 22222 MW; E2B25293226A09E4 CRC64; PSLNLHHLCI SLSGFHTLQQ MYGCDLRKDG SKAGYRQYAY DGKDFISFDK ETLTWTAADV EAQTTKRKWD AQSMRNQYLK AYLEEECIEW LKKYLEYGKE TLLRTETPEV MVTRKVDHDG METLICRVGG FYPKEIDIEW TRDGEVWTQD VFHGLVSPNS DGTYYTWRSI TVDPKERERY QCHVEHNGL // ID H9GVB8_ANOCA Unreviewed; 189 AA. AC H9GVB8; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 12-SEP-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000021228}; DE Flags: Fragment; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000021228, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000021228} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000021228} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 28377.ENSACAP00000021228; -. DR Ensembl; ENSACAT00000022785; ENSACAP00000021228; ENSACAG00000025947. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9GVB8; -. DR OMA; YLEGICI; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000025947; Expressed in 2 organ(s), highest expression level in heart. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}. FT DOMAIN 108 189 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSACAP00000021228}. SQ SEQUENCE 189 AA; 22136 MW; 4A83C7A36E786E1B CRC64; PSLNLHHLCI SLSGFHTLQQ MYGCDLRKDG SKAGYRQYAY DGKDFISFDK ETLTWTAADV EAQITKRTWD AQSMRNQYLK AYLEEECIGW LQKYLEYGKE TLLRTETPEV MVTRKVDHDG METLICRVGG FYPKEIDIEW TRDGEVWTQD VFHGLVSPNS DGTYYTWRSI TVDPKERERY QCHVEHDGL // ID H9H0W8_MELGA Unreviewed; 327 AA. AC H9H0W8; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 18-JUL-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMGAP00000005893}; OS Meleagris gallopavo (Wild turkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Meleagridinae; Meleagris. OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000005893, ECO:0000313|Proteomes:UP000001645}; RN [1] {ECO:0000313|Ensembl:ENSMGAP00000005893, ECO:0000313|Proteomes:UP000001645} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475; RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A., RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K., RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C., RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A., RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., RA de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., RA Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P., RA Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S., RA Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M., RA Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S., RA Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F., RA Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P., RA Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.; RT "Multi-platform next-generation sequencing of the domestic turkey RT (Meleagris gallopavo): genome assembly and analysis."; RL PLoS Biol. 8:E1000475-E1000475(2010). RN [2] {ECO:0000313|Ensembl:ENSMGAP00000005893} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9103.ENSMGAP00000005893; -. DR Ensembl; ENSMGAT00000006637; ENSMGAP00000005893; ENSMGAG00000005937. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9H0W8; -. DR OMA; MKNATQT; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001645; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001645}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001645}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 271 295 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 177 264 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 327 AA; 37037 MW; 311958F4E88476FD CRC64; RYFLTGMTDP GPGMPQFTAV GYVDGKAFGN YDSERRTVRP IVDWLPREDR EHWDAETKKA RSGELDFYVG LGWLREHYNK SGGSHTLQKM FGCDILEDGS VRGYDQYAFD GRDYIAFEMD TMTFTAANAV AQSTKRKWES EGTYAERWKH ELGTVCVENL RRYRGARKDR AERRERPEVR VRGKEADGIL TLSCRAHSFY PRPITISWMK DGVVQDQETH WGGIVPNSDG TYHASATIDV PPGDWDKYQC RVEHASLLQS SFFSWELQPN LILIVAGAII TVVAVVAVVA GLVVWRSKSG KDEKCYRAEL GHDGESSSMA TGTVWDR // ID H9H0Y9_MELGA Unreviewed; 330 AA. AC H9H0Y9; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMGAP00000006312}; DE Flags: Fragment; OS Meleagris gallopavo (Wild turkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Meleagridinae; Meleagris. OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000006312, ECO:0000313|Proteomes:UP000001645}; RN [1] {ECO:0000313|Ensembl:ENSMGAP00000006312, ECO:0000313|Proteomes:UP000001645} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475; RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A., RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K., RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C., RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A., RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., RA de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., RA Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P., RA Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S., RA Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M., RA Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S., RA Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F., RA Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P., RA Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.; RT "Multi-platform next-generation sequencing of the domestic turkey RT (Meleagris gallopavo): genome assembly and analysis."; RL PLoS Biol. 8:E1000475-E1000475(2010). RN [2] {ECO:0000313|Ensembl:ENSMGAP00000006312} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9103.ENSMGAP00000006312; -. DR Ensembl; ENSMGAT00000007060; ENSMGAP00000006312; ENSMGAG00000006286. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9H0Y9; -. DR OMA; GYVDSHP; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001645; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001645}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001645}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 330 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003621237. FT TRANSMEM 289 319 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 197 282 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMGAP00000006312}. SQ SEQUENCE 330 AA; 36879 MW; 02CFD8DA9995B42D CRC64; LVPSEAVVLG LLLGSLSTTV CESHSLRYFV TAMTDPGPGM PQFVIIGYVD GKAFGNYDSK SWRAQPIVEI LPQEDWEHWD AQTQRAQDGE VDLYWFLGRL QKLYNKSGGS HTLQKMFGCD ILEDGGIQGY NQYTFDRRDY IAFDMDTMTF TAAGAVAQIT KRRLEEEGTC AVRFLCVENL RRYLEHGKAV LKRRERPEVQ VRGKEADGIL TLSCRAHGFY PWPIAIWRKD GKVRDQETHW GRIVPNSDST CHASATIDVL PDGDKYRCRV EHASLPQPSL FSWKPQPNLI PIAAGAVIAI MAVIAIMAVI AAIVGLVVWR ASHVKAEGRG // ID H9H1N2_MELGA Unreviewed; 233 AA. AC H9H1N2; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMGAP00000010090}; OS Meleagris gallopavo (Wild turkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Meleagridinae; Meleagris. OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000010090, ECO:0000313|Proteomes:UP000001645}; RN [1] {ECO:0000313|Ensembl:ENSMGAP00000010090, ECO:0000313|Proteomes:UP000001645} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475; RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A., RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K., RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C., RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A., RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., RA de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., RA Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P., RA Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S., RA Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M., RA Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S., RA Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F., RA Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P., RA Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.; RT "Multi-platform next-generation sequencing of the domestic turkey RT (Meleagris gallopavo): genome assembly and analysis."; RL PLoS Biol. 8:E1000475-E1000475(2010). RN [2] {ECO:0000313|Ensembl:ENSMGAP00000010090} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9H1N2; -. DR STRING; 9103.ENSMGAP00000010090; -. DR Ensembl; ENSMGAT00000010936; ENSMGAP00000010090; ENSMGAG00000009766. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9H1N2; -. DR OMA; VEHESLL; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001645; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001645}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001645}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 192 217 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 97 176 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 233 AA; 26056 MW; E751285816FD31C0 CRC64; VSGSHTVQRK IGCDILEDGT TRGYHQVAYD GRDFIAFDKD TKTFTATVPE AVLTKRRWED DGSVAERFKH YLEETCVEWL RTYMERGKAE LERREPPEVR VWGKKADGIL TLSCRAHGFY PRPIDVSWMK DGVAQNQDTQ SGGIAPNSDG TYHTLVTIDA RPEDWDKYQC RVEHASLQQP GFYSWEPSQP NLVPIVVGVI VAIVAIAIVG GVGFIIYRSH AGKKGKGYNI APG // ID H9H295_MELGA Unreviewed; 59 AA. AC H9H295; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 20-JUN-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMGAP00000017795}; DE Flags: Fragment; OS Meleagris gallopavo (Wild turkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Meleagridinae; Meleagris. OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000017795, ECO:0000313|Proteomes:UP000001645}; RN [1] {ECO:0000313|Ensembl:ENSMGAP00000017795, ECO:0000313|Proteomes:UP000001645} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475; RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A., RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K., RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C., RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A., RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., RA de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., RA Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P., RA Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S., RA Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M., RA Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S., RA Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F., RA Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P., RA Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.; RT "Multi-platform next-generation sequencing of the domestic turkey RT (Meleagris gallopavo): genome assembly and analysis."; RL PLoS Biol. 8:E1000475-E1000475(2010). RN [2] {ECO:0000313|Ensembl:ENSMGAP00000017795} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSMGAT00000019578; ENSMGAP00000017795; ENSMGAG00000016965. DR InParanoid; H9H295; -. DR Proteomes; UP000001645; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001645}; KW Reference proteome {ECO:0000313|Proteomes:UP000001645}. FT DOMAIN 2 59 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMGAP00000017795}. SQ SEQUENCE 59 AA; 6709 MW; 99B9F45738CB4FFA CRC64; VSGSHTVQRM YGCDILGNST TRGYNQYAYD GRDFIAFDKD KKTFTAAVPE AVLTKRKWE // ID H9H2S6_MACMU Unreviewed; 155 AA. AC H9H2S6; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000002225}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000002225, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000002225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002225}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000002225} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002225}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030519; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMMUT00000002354; ENSMMUP00000002225; ENSMMUG00000001660. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9H2S6; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF342059; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000001660; Expressed in 13 organ(s), highest expression level in peripheral blood mononuclear cell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 155 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959603. FT TRANSMEM 122 148 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 25 115 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 155 AA; 17406 MW; A7DCCD2B50FB2A7C CRC64; MVVMAPRTLL LLLSGALALT ETWAGSHSMR YFSAAVSRPG RGEPRFIPVG YVDNTQFVRL DSDAASPRME PRAPWVEQEG PEYWEEETRN IKAHAHTDRV NLRTLRSCYN QSQAEQSFQP TIPIMGIIAG LVVFAAVVTE AVVTFVLWRK KSSDR // ID H9H2V2_MACMU Unreviewed; 362 AA. AC H9H2V2; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000003461}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000003461, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000003461} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000003461}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000003461} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000003461}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9544.ENSMMUP00000003461; -. DR Ensembl; ENSMMUT00000003662; ENSMMUP00000003461; ENSMMUG00000041144. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9H2V2; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Unplaced. DR Bgee; ENSMMUG00000002570; Expressed in 13 organ(s), highest expression level in peripheral blood mononuclear cell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959608. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 41095 MW; 6390F572880AAB25 CRC64; MAPRTLLLLL SGALALTETW AGSHSLRYFH TAVSRPGRWE PRFISVGYVD DTQFVRFDSD AESPRMEPRA PWMEQEGPEY WEEQTRIAKE AAQTFRGNLR TLRGYYNQSE TGSHTLQWMY GCDLGPDGRL LRGYDQSAYD GRDYIVLNED LRSWTAADMA AQNTQRKWEA ARAAERQRAY LEGECLEWLR RYLENGKEML QRADPPKTHV THHPVSDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPGGDG TFQKWAAVVV PSGEEHRYRC HVQHEGLPEP VTLRWEPSSQ STIPIVGIVV GLAVLAVVVT GAVVAAVMWR RKSSGHFLPT RGKRGSYSQA ASHPLYNSSC PT // ID H9H2Y1_MACMU Unreviewed; 354 AA. AC H9H2Y1; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000005021}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000005021, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000005021} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000005021}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000005021} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000005021}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9544.ENSMMUP00000005021; -. DR Ensembl; ENSMMUT00000005333; ENSMMUP00000005021; ENSMMUG00000041144. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9H2Y1; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Unplaced. DR Bgee; ENSMMUG00000003765; Expressed in 13 organ(s), highest expression level in peripheral blood mononuclear cell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 354 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959611. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 354 AA; 40310 MW; 2C541D64B94DE908 CRC64; MAPRTLLLLL SGALALTETW AGSHSLRYFH TAVSRPGRWE PRFISVGYVD DTQFVRFDSD AESPRMEPRA PWMEQEGPEY WEEQTRIAKE AAQTFRGNLR TLRGYYNQSE TGSHTLQWMY GCDLGPDGRL LRGYDQSAYD GRDYIVLNED LRSWTAADMA AQNTQRKWEA ARAAERQRAY LEGECLEWLR RYLENGKEML QRADPPKTHV THHPVSDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPGGDG TFQKWAAVVV PSGEEHRYRC HVQHEGLPEP VTLRWEPSSQ STIPIVGIVV GLAVLAVVVT GAVVAAVMWR RKSSGREGVR APGRRSYSQA ACKW // ID H9H2Y6_MACMU Unreviewed; 331 AA. AC H9H2Y6; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000005183}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000005183, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000005183} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000005183}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000005183} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000005183}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030553; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9544.ENSMMUP00000005183; -. DR Ensembl; ENSMMUT00000005506; ENSMMUP00000005183; ENSMMUG00000039519. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9H2Y6; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000003886; Expressed in 13 organ(s), highest expression level in rectum. DR ExpressionAtlas; H9H2Y6; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 331 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959613. FT TRANSMEM 292 316 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 193 271 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 331 AA; 37006 MW; FE424BADBCD21AB4 CRC64; MALRTLLLLL SALTKTWAGS HSLKYFHTSV SRPGRGEPRF ISGWPTWTTP SSSRGRRGWS RRGRGIGTRR HGAARDTART FRVNLKTLPR ATYNQSEAGS HTLQWMHGCD LGPDGRFLRG YEQFAYDGKD YLTLNEDLRS WSAVDTAAQI SEQKSNDGSE AEHQRAYLED TCVEWLHRYL ENGKETLQRS ESPKTHVTRH PVSDHEATLR CWALGFYPAE ITVTWQRDGE DQTQDTELVE TRPAGDGTFQ KWAAVVVPSG EEQRYTCHVQ HEGLPEPLIL RWEPSSQSSI PIVGIIVGLV LLGAVVTGAV VAAVMWRKSS GRKGGSYSQA S // ID H9H333_MACMU Unreviewed; 227 AA. AC H9H333; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000007371}; GN Name=RAET1E {ECO:0000313|Ensembl:ENSMMUP00000007371}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000007371, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000007371} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000007371}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000007371} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000007371}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03031936; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9544.ENSMMUP00000007371; -. DR Ensembl; ENSMMUT00000007844; ENSMMUP00000007371; ENSMMUG00000003953. DR eggNOG; ENOG410JBPA; Eukaryota. DR eggNOG; ENOG411150N; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; H9H333; -. DR OrthoDB; EOG091G0NI5; -. DR TreeFam; TF339658; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000003953; Expressed in 5 organ(s), highest expression level in lung. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR029287; RAE-1. DR Pfam; PF14586; MHC_I_2; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 32 {ECO:0000256|SAM:SignalP}. FT CHAIN 33 227 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959616. FT TRANSMEM 188 210 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 26 163 MHC_I_2. {ECO:0000259|Pfam:PF14586}. SQ SEQUENCE 227 AA; 25935 MW; E2133BE44EAEE8CF CRC64; VPRMPLTCSP VRLLLLLLLL LTVLEIMYDS DSNMVKPLGL LGKKVNATST WGELTQTLGE VGRDLRMLLL DIKPQIKTSS PSTLQVEMLC QREAERCTGA SWQFTINGEK CLLLDAMNMT WTVINHEASK IKETWKKDRG LEKYFRKLSV GDCDHWLREF SEQWEAMPEP TVSPVNVSDV HGSSSSLLYT WIILGAFILF VLMGIFLIYI RWQKGEWQAG LWPLKMS // ID H9H3F0_MACMU Unreviewed; 359 AA. AC H9H3F0; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000013944}; GN Name=LOC694372 {ECO:0000313|Ensembl:ENSMMUP00000013944}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000013944, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000013944} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000013944}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000013944} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000013944}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSMMUT00000014885; ENSMMUP00000013944; ENSMMUG00000039687. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9H3F0; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Unplaced. DR Bgee; ENSMMUG00000012835; Expressed in 14 organ(s), highest expression level in peripheral blood mononuclear cell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 359 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959624. FT TRANSMEM 296 320 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 197 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 39807 MW; 9137123DC98218AF CRC64; MAPRTLLLLL SGALALTETW AGSHSLRYFG TTVSRPGRGE PRFISVGYVD DTQFVRFDSD AESPRMEPRA PWMEQEGPEY WEEETRIAKA RAQTERGNLR TALRYYNQSE GGSHTLQKMC GCDLGPDGRL LRGYYQSAYD GRDYIALNED LRSWTAAGEA AQNTQRKWEA AGEAEQRRWL RRYLEKGKET LQRADPPKTH VTHHPVSDHE ATLRCWALGF YPAEITLTWQ RDGEEQTQDT ELVETRPGGD GTFQKWGAVV VPSGEEQRYT CHVQHEGLPE PLTLRWEPSS QSTIPIMGIV AGLAVLAVVV TGAVVAAVMW RRKSSGGKGG SYSQAACNSC FCSTPASDSA QGSDVSLTA // ID H9H3U5_MACMU Unreviewed; 361 AA. AC H9H3U5; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000021169}; GN Name=LOC714964 {ECO:0000313|Ensembl:ENSMMUP00000021169}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000021169, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000021169} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000021169}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000021169} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000021169}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSMMUT00000022630; ENSMMUP00000021169; ENSMMUG00000047461. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000006718; Unplaced. DR Bgee; ENSMMUG00000016091; Expressed in 14 organ(s), highest expression level in CD4-positive helper T cell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 361 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959628. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 361 AA; 40774 MW; 81158F7A1AA566F2 CRC64; VRVMAPRTLL LLLSGALALT ETWAGSHSLR YFHTAVSRPG RWEPRFISVG YVDDTQFVRF DSDAASPREE PRAPWAEQEG PEYWEEQTRN AEAHAQSHRV SLRNLRGYYN QSEWGSHTLQ KMYGCDLGPD GRLLRGYDQY AYDGKDYIAL NEDLRSWTAA DMAAQNTQRK WEAARAAEKL RAYLEGTCVK WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEIILT WQRDGEDQTQ DTELVETRPA GDGTFQKWGA VVVPSGEEQR YTCHVQHKGL LEPLTLRWEP SSQSTIPIVG IVVGLAVLAV VVTGAVVAAV MWRRKSSGRE GVRGRTSDSA QGSDVSHSLK R // ID H9H3U6_MACMU Unreviewed; 273 AA. AC H9H3U6; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000021172}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000021172, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000021172} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000021172}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000021172} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000021172}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSMMUT00000022633; ENSMMUP00000021172; ENSMMUG00000049007. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9H3U6; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Unplaced. DR Bgee; ENSMMUG00000016095; Expressed in 13 organ(s), highest expression level in peripheral blood mononuclear cell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 273 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959630. FT TRANSMEM 214 240 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 25 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 252 267 MHC_I_C. {ECO:0000259|Pfam:PF06623}. SQ SEQUENCE 273 AA; 30698 MW; 0CBF17C423038453 CRC64; MAVMAPRTLL LVLSGVLALT RTWAGSHSMR YFYTSMSRPG RGEPRFFAVG YVDDTQFVRF DSDAESPRME PRAPWVEQEG PEYWDRETQN MKNATQTYRG NLRTLLRYYN QSEAGSHTIQ KMYGCDLGPD GRLLRGYEQF AYDGRDYIAL NEDLRSWTAA DMAAQNTQRK WEAAGAAEQH RTYLEGECLE WLRRYLENGK ETLQRAEPSS QSTILIVGII AGLVLLGTVV TGAVVAAVMW RRKSSGEEGV RSSDSAQGSD VSLTALKVRP WGA // ID H9H407_MACMU Unreviewed; 344 AA. AC H9H407; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000024214}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000024214, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000024214} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000024214}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000024214} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000024214}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSMMUT00000025877; ENSMMUP00000024214; ENSMMUG00000049007. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000006718; Unplaced. DR Bgee; ENSMMUG00000003765; Expressed in 13 organ(s), highest expression level in peripheral blood mononuclear cell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 285 311 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 188 276 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 344 AA; 39027 MW; 6837930F2778382F CRC64; RGQGSHSMRY FYTSMSRPGR GEPRFFAVGY VDDTQFVRFD SDAESPRMEP RAPWVEQEGP EYWDRETQNM KNATQTYRGN LRTLLRYYNQ SEAGSHTIQK MYGCDLGPDG RLLRGYEQFA YDGRDYIALN EDLRSWTAAD MAAQNTQRKW EAAGAAEQHR TYLEGECLEW LRRYLENGKE TLQRADPPKT HVTHHPVSDY EATLRCWALG FYPAEITLTW QRDGEEQTQD TELVETRPTG DGTFQKWAAV VVPSGEEQRY TCHVQHEGLP EPLTLRWEPS SQSTILIVGI IAGLVLLGTV VTGAVVAAVM WRRKSSGEEG VRSSDSAQGS DVSLTALKVR PWGA // ID H9H440_MACMU Unreviewed; 113 AA. AC H9H440; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 28. DE SubName: Full=Uncharacterized protein LOC700391 precursor {ECO:0000313|Ensembl:ENSMMUP00000025934}; GN Name=MAMU-B {ECO:0000313|Ensembl:ENSMMUP00000025934}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000025934, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000025934} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000025934}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000025934} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000025934}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030595; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030596; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030597; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030598; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030599; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030600; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030601; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030602; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030603; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030604; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMMUT00000027725; ENSMMUP00000025934; ENSMMUG00000045600. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000014879; Expressed in 13 organ(s), highest expression level in testis. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 113 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959636. FT DOMAIN 22 112 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 113 AA; 12843 MW; 0324C04F4215A625 CRC64; LAPRTLLLLL SGALALTETW AGSHSLRYFS TTVSWPGRGE PRFISVGYVD DTQFVRFDSD AESPREEPRA PWAEQEGPEY WEEQTRNTEA HAQNHRVCLR TVPGYYNQSE AGE // ID H9H467_MACMU Unreviewed; 343 AA. AC H9H467; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 43. DE SubName: Full=Mamu class I histocompatibility antigen, alpha chain F precursor {ECO:0000313|Ensembl:ENSMMUP00000027180}; GN Name=MAMU-F {ECO:0000313|Ensembl:ENSMMUP00000027180}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000027180, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000027180} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000027180}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000027180} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000027180}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030514; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030515; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9544.ENSMMUP00000027180; -. DR Ensembl; ENSMMUT00000029052; ENSMMUP00000027180; ENSMMUG00000008799. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9H467; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000032619; Expressed in 13 organ(s), highest expression level in peripheral blood mononuclear cell. DR ExpressionAtlas; H9H467; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 343 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959643. FT TRANSMEM 307 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 343 AA; 38860 MW; 5D635D53C051A1F8 CRC64; MAPRTLLLVL SGALALTETW AGSHSLRYFS TAVSRPGRRE PQYRYIAVEY VDDTQFLRFD SDAAIPRMEP REPWVEQEGP QYWERTTGYA KANARTDRVA LRKLLLRYNQ SEAGSHTLQG MNGCDMGPDG RLLRGYHQHA YDGKDYISLN EDLRSWTAAD TVARITQRFY EAEEYAEEFR TYLEGECLEL LRRYLENGKE TLQRADPPKA HVAHHPISDR EATLRCWALG FYPAEITLTW QRDGEEQTQD TELVETRPAG DGTFQKWAAV VVPSGEEQRY TCHVQHEGLP QPLTLRWESS SQPTIPIVGI VAGLAVLAVV VTGAVVTAVM WRRKSSGREG GKV // ID H9H493_MACMU Unreviewed; 326 AA. AC H9H493; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000029075}; GN Name=LOC723514 {ECO:0000313|Ensembl:ENSMMUP00000029075}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000029075, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000029075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000029075}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000029075} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000029075}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9544.ENSMMUP00000029075; -. DR Ensembl; ENSMMUT00000031065; ENSMMUP00000029075; ENSMMUG00000042067. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9H493; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Unplaced. DR Bgee; ENSMMUG00000030591; Expressed in 13 organ(s), highest expression level in peripheral blood mononuclear cell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 292 316 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 193 281 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 326 AA; 36677 MW; 16AFC0FF08190E6D CRC64; RALGTRGGGS HSLRYFYTAV SRPGRGQPRF ISVGYVDDTQ FVRFDSDAES PREEPRAPWV EQEGPEYWDR NTRIYKAATQ NYREGLQNLR GYYNQSEAGS HTFQRMYGCD LGPDGRLLRG YEQFAYDGKD YIALNGDLRS WTAADMAAQN TQRKWEAAGA AERVRVYLEG RCVESLRRYL ENGKETLQRA DPPKTHVTHH PVSDHEATLR CWALGFYPAE ITLTWQRDGE DQTQDTELVE TRPAGDGTFQ KWAAVVVPSG KEQRYTCHVQ HEGLPEPLTL RWEPSSQSTI PMVGIIAGLV LLGAVVTGAV VAAVMWRRKS SGKEGG // ID H9H4C6_MACMU Unreviewed; 297 AA. AC H9H4C6; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000030889}; GN Name=LOC715737 {ECO:0000313|Ensembl:ENSMMUP00000030889}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000030889, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000030889} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000030889}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000030889} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000030889}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030526; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030527; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMMUT00000033010; ENSMMUP00000030889; ENSMMUG00000019888. DR GeneTree; ENSGT00760000118960; -. DR OrthoDB; EOG0907079Q; -. DR TreeFam; TF342059; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000023461; Expressed in 13 organ(s), highest expression level in peripheral blood mononuclear cell. DR ExpressionAtlas; H9H4C6; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 297 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959646. FT TRANSMEM 214 240 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 25 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 252 267 MHC_I_C. {ECO:0000259|Pfam:PF06623}. SQ SEQUENCE 297 AA; 32987 MW; 1159FB722F646276 CRC64; MAIMAPRTLL LVLSGALALT QTRAGSHSMR YFYTSMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWVEQEG PEYWDRETQN MKTATQNAPV ALRNLRGYYN QSEVGSHTFQ RMVGCDLGPD GRLLRGYEQY AYDGRDYIAL NEDLRSWTAA DMAAQNTQRK WEAADVAERM RAYLEGECVE WLPRYLENGK ETLQRAEPSS QSTIPIVGII AGLVLLGAVV TGAVVAAVMW RRKSSGKEGV RSSDSAQGSD VSLTACKGET LGGLMCVGCW GEQWTQLCCG VSLTWMY // ID H9H4F3_MACMU Unreviewed; 345 AA. AC H9H4F3; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000032222}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000032222, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000032222} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000032222}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000032222} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000032222}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9544.ENSMMUP00000032222; -. DR Ensembl; ENSMMUT00000039137; ENSMMUP00000032222; ENSMMUG00000049007. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9H4F3; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Unplaced. DR Bgee; ENSMMUG00000029029; Expressed in 14 organ(s), highest expression level in peripheral blood mononuclear cell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 345 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959647. FT TRANSMEM 306 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 345 AA; 39362 MW; 6B915255BE745504 CRC64; MAVMAPRTLL LVLSGVLALT RTWAGSHSMR YFYTSMSRPG RGEPRFFAVG YVDDTQFVRF DSDAESPRME PRAPWVEQEG PEYWDRETQN MKNATQTYRG NLRTLLRYYN QSEAGSHTIQ KMYGCDLGPD GRLLRGYEQF AYDGRDYIAL NEDLRSWTAA DMAAQNTQRK WEAAGAAEQH RTYLEGECLE WLRRYLENGK ETLQRADPPK THVTHHPVSD YEATLRCWAL GFYPAEITLT WQRDGEEQTQ DTELVETRPT GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQSTILIVG IIAGLVLLGT VVTGAVVAAV MWRRKSSGHF LLIDR // ID H9H4S5_MACMU Unreviewed; 95 AA. AC H9H4S5; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000033404}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000033404, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000033404} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000033404}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000033404} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000033404}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030539; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMMUT00000013934; ENSMMUP00000033404; ENSMMUG00000043529. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00900000141162; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000029555; Expressed in 14 organ(s), highest expression level in peripheral blood mononuclear cell. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 95 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959651. FT DOMAIN 22 94 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 95 AA; 10552 MW; B4B0A5D3B0F7A0E5 CRC64; MAPRTLLLLL SGTLALTETK AGSLSLRYFS TAVSRPGRGE PRFIAVGYVD NTQFVRFDSD AASPRMEPRA WWMEQEGPEY WELQTLGAKA QAQTG // ID H9H4S7_MACMU Unreviewed; 357 AA. AC H9H4S7; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000033407}; GN Name=LOC720309 {ECO:0000313|Ensembl:ENSMMUP00000033407}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000033407, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000033407} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000033407}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000033407} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000033407}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSMMUT00000040339; ENSMMUP00000033407; ENSMMUG00000043614. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000006718; Unplaced. DR Bgee; ENSMMUG00000029555; Expressed in 14 organ(s), highest expression level in peripheral blood mononuclear cell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 357 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959652. FT TRANSMEM 306 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 357 AA; 40550 MW; ADD449E551691EFF CRC64; MQVMAPRTLL LLLSGALALT ETWAVSHSMR YFSTAVSRPG RREPWYLEVG YVDDTQFVWF DSDAESPRME PRAPWVEQEG PEYWDRNTRR AKGNAQTERG SLRTLLRYYN QSEGGSHTFQ RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DMAARFTQRK WEAAREAEQR RAYLEGTCVE WLRRHLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEEQTQ DTELVETRPG GDGTFQKWGA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQSTIPIVD IVAVVVTGAV VAAVMWRRKS SGREGVSCFC STPAKDNAQG SDESLMA // ID H9H4S9_MACMU Unreviewed; 377 AA. AC H9H4S9; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000033409}; GN Name=LOC715737 {ECO:0000313|Ensembl:ENSMMUP00000033409}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000033409, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000033409} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000033409}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000033409} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000033409}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030526; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03030527; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9544.ENSMMUP00000033409; -. DR Ensembl; ENSMMUT00000040341; ENSMMUP00000033409; ENSMMUG00000019888. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9H4S9; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000029555; Expressed in 14 organ(s), highest expression level in peripheral blood mononuclear cell. DR ExpressionAtlas; H9H4S9; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 377 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959653. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 377 AA; 42038 MW; 40ED8B39FD9AF6BC CRC64; MAIMAPRTLL LVLSGALALT QTRAGSHSMR YFYTSMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWVEQEG PEYWDRETQN MKTATQNAPV ALRNLRGYYN QSEVGSHTFQ RMVGCDLGPD GRLLRGYEQY AYDGRDYIAL NEDLRSWTAA DMAAQNTQRK WEAADVAERM RAYLEGECVE WLPRYLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGKEQR YTCHVQHEGL PKPLTLKWEP SSQSTIPIVG IIAGLVLLGA VVTGAVVAAV MWRRKSSGKE GVRSSDSAQG SDVSLTACKG ETLGGLMCAR FVHAFSL // ID H9H4X3_MACMU Unreviewed; 342 AA. AC H9H4X3; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000034951}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000034951, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000034951} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034951}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000034951} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000034951}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030553; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9544.ENSMMUP00000034951; -. DR Ensembl; ENSMMUT00000041942; ENSMMUP00000034951; ENSMMUG00000039519. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9H4X3; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000030209; Expressed in 14 organ(s), highest expression level in spleen. DR ExpressionAtlas; H9H4X3; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 342 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959657. FT TRANSMEM 294 318 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 195 273 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 342 AA; 38775 MW; 45502243E0672EC9 CRC64; MALRTLLLLL SALTKTWAGE LFPHFRVPAR PRGAPLHLRV AYVDDTQFVR YDSDRRRVRG MSARAPWVEQ EGPRYWDQET RSGSFTRFRF QFRPKSLRVG GSHTLQWMHG CDLGPDGRFL RGYEQFAYDG KDYLTLNEDL RSWSAVDTAA QISEQKSNDG SEAEHQRAYL EDTCVEWLHR YLENGKETLQ RSESPKTHVT RHPVSDHEAT LRCWALGFYP AEITVTWQRD GEDQTQDTEL VETRPAGDGT FQKWAAVVVP SGEEQRYTCH VQHEGLPEPL ILRWEPSSQS SIPIVGIIVG LVLLGAVVTG AVVAAVMWRK SSGREGRGVE SEFSCPTGGF KP // ID H9H4X4_MACMU Unreviewed; 359 AA. AC H9H4X4; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 12-SEP-2018, entry version 42. DE SubName: Full=MHC class 1 protein {ECO:0000313|EMBL:CUS58452.1}; GN Name=Mamu-B {ECO:0000313|EMBL:CUS58452.1}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|EMBL:CUS58452.1}; RN [1] {ECO:0000313|EMBL:CUS58452.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=GD057 {ECO:0000313|EMBL:CUS58452.1}; RA Otting N., Wiseman R., Karl J.A., Doxiadis G.G.M., Bontrop R.E.; RT "New MHC class I alleles in rhesus macaques (Macaca mulatta)."; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; LN899742; CUS58452.1; -; mRNA. DR STRING; 9544.ENSMMUP00000034994; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G09OH; -. DR Bgee; ENSMMUG00000030234; Expressed in 13 organ(s), highest expression level in peripheral blood mononuclear cell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 359 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5009956330. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 40022 MW; 49DFB18C76C355EF CRC64; MAPRTLLLLL SGALALTETW AGSHSLRYFG TAVSRPGRGE PRFIAVGYVD DTQFVRFDSD AASPRTEPRA PWVEQEGPEY WEEETRRAKA RAQTDRADLR TLRGYYNQSE AGSHTLQWMA GCDLGPNGRL LRGYHQSAYD GKDYIALNRD LRSWIAADMA AQNTQRKWEA TRYAERFRAY LEGPCLEWLR RYLENGKKTL QHADPPKTHV THHPVSDHEA TLRCWALGFY PAEITLTWQR DGEDQTQDIE FVETRPAGDG TFQKWGAVVV PSGEEQRYTC HVQHKGLPEP LTLRWEPSSQ STIPIVGIVV GLAVLAVVVT GAVVAAVMWR RKSSGGKGGS YSQAVSSDSA QGSDVSLTA // ID H9H556_MACMU Unreviewed; 354 AA. AC H9H556; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000036697}; GN Name=LOC100424348 {ECO:0000313|Ensembl:ENSMMUP00000036697}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000036697, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000036697} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000036697}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000036697} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000036697}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9544.ENSMMUP00000036697; -. DR Ensembl; ENSMMUT00000043706; ENSMMUP00000036697; ENSMMUG00000041305. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9H556; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Unplaced. DR Bgee; ENSMMUG00000030910; Expressed in 13 organ(s), highest expression level in CD4-positive helper T cell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 354 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959664. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 354 AA; 39987 MW; 891689AE392F6486 CRC64; MAPRALLLLL SAALALTETR AGSHSLRYFS AGTSRPGRGE PRFISVGYVD DTQFLRFDSD AASPRMEPRA PWAEQEGPEY WEEQTGLAKD FTQSFRVGLG NLRGYYNQSE AGSHTLQWMY GCDLGPDGRL LRGYHQFAYD GKDYIALNGD LRSWTAADTA AQITQRKWEA AREAEQWRAH LEGTCVEWLR RHLENGKEML QRADPPKTHM THHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPAGDG TYQKWGAVVV PSGEEQRYTC HVQHEGLPEP LTLRWEPSSQ STIPIVGIVV GLAVLAVVVT GAVVAAVMWR RKSSGREGRP GRQFRMWLLH MEHL // ID H9H5G5_MACMU Unreviewed; 113 AA. AC H9H5G5; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000040106}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000040106, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000040106} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000040106}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000040106} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000040106}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSMMUT00000047080; ENSMMUP00000040106; ENSMMUG00000045208. DR GeneTree; ENSGT00900000141162; -. DR Proteomes; UP000006718; Unplaced. DR Bgee; ENSMMUG00000001660; Expressed in 13 organ(s), highest expression level in peripheral blood mononuclear cell. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 113 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959663. FT DOMAIN 22 112 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 113 AA; 12745 MW; A12469F7F3B332E4 CRC64; MAPRTLLLLL SGALALTETW AGSHSMRYFS AAVSRPGRGK PRFIAVGHVD DTQFLRLDSD AASPRMEPRA PWVEQEGPEY WEEETRIAKA HAQTDRVNLR TLRSYYNQSQ AGE // ID H9H5I4_MACMU Unreviewed; 348 AA. AC H9H5I4; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000040543}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000040543, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718}; RG Macaca mulatta Genome Sequencing Consortium; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMMUP00000040543} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000040543}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000040543} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000040543}; RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; JSUE03030553; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9544.ENSMMUP00000040543; -. DR Ensembl; ENSMMUT00000047508; ENSMMUP00000040543; ENSMMUG00000039519. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9H5I4; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000006718; Chromosome 4. DR Bgee; ENSMMUG00000032227; Expressed in 14 organ(s), highest expression level in prefrontal cortex. DR ExpressionAtlas; H9H5I4; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 348 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008959668. FT TRANSMEM 292 316 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 193 271 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 348 AA; 38870 MW; CE591220EC5087DE CRC64; MALRTLLLLL SALTKTWAGS HSLKYFHTSV SRPGRGEPRF ISGWPTWTTP SSSRGRRGWS RRGRGIGTRR HGAARDTART FRVNLKTLPR ATYNQSEAGS HTLQWMHGCD LGPDGRFLRG YEQFAYDGKD YLTLNEDLRS WSAVDTAAQI SEQKSNDGSE AEHQRAYLED TCVEWLHRYL ENGKETLQRS ESPKTHVTRH PVSDHEATLR CWALGFYPAE ITVTWQRDGE DQTQDTELVE TRPAGDGTFQ KWAAVVVPSG EEQRYTCHVQ HEGLPEPLIL RWEPSSQSSI PIVGIIVGLV LLGAVVTGAV VAAVMWRKSS GREGRGSLFV HRPGSDSTGE LTESTSQL // ID H9KVZ8_CALJA Unreviewed; 374 AA. AC H9KVZ8; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000005685}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000005685, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000005685} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000005685} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9483.ENSCJAP00000005685; -. DR Ensembl; ENSCJAT00000005992; ENSCJAP00000005685; ENSCJAG00000046546. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9KVZ8; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 374 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015327897. FT TRANSMEM 306 332 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 374 AA; 42325 MW; 44EE680826B4D9C0 CRC64; MAVLARRTLL LLLLGALAQT KTWAGSHFMR YFHIAVSRPG RGEPRYLEVG YVDDTQFVRF DSDAARPRME PRAPWVEQEG PEYWEEETQR AKDVAQTFRV NLQTLRGYYN QSGAGSHTLQ LMYGCDLGPD WRLLRGYLQF AYDAKDYISL NHDLSSWTAA DTAAQITQRK WEAANVAEEW RAYMEGTCLE WLRRHLKNGK ETLQRADPPK THVTHHPISD HEAILRCWAL GFYPAEITLT WQRDGEDQTQ DMELVETRPA GDGNFQKWAA VVVPSGEEQR YMCHVQHEGL LEPLTLRWEP SSQLTISIMG IVAGLVVLGA VVIGVMVTAV MWRKKSSGRE GSDSTQGSDV SLMACKGETL RGPKWLGVGQ KGKD // ID H9KW16_CALJA Unreviewed; 296 AA. AC H9KW16; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 12-SEP-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000006672}; GN Name=LOC100403653 {ECO:0000313|Ensembl:ENSCJAP00000006672}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000006672, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000006672} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000006672} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR RefSeq; XP_008992347.2; XM_008994099.2. DR ProteinModelPortal; H9KW16; -. DR Ensembl; ENSCJAT00000007045; ENSCJAP00000006672; ENSCJAG00000038321. DR GeneID; 100403653; -. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9KW16; -. DR OMA; RREPWYL; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008225; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 296 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015356820. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 296 AA; 34003 MW; 48D6DAEB16509371 CRC64; MGVMAPRTLL LLSTALLLTK TRVDSHSLRY FYTAVSQPGR GEPRVISVGY VDDTQVARFD SDAASPRMEP RAPWVEQEGL EYWEEETRTA LDTAQNFRVK LRTLLRYYNQ SEAMSHTYQG VFGCDLGLHG RLLRGYYQFA YDGKDYIALN EDLRSWSAAD LAAQITQRKW EVQKHAEDVR AYLEGTCVDR LRRYLKNGKE TLQRADPPKT HVTHHPVSDH EATLRCWALG FYPAEITLTW QRDGEEQTQD MELVETRPAG DGNFQKWAAV VVPSGEEQRY TCHVHHEGLP EPLTLR // ID H9KW17_CALJA Unreviewed; 277 AA. AC H9KW17; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 12-SEP-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000006690}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000006690, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000006690} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000006690} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9KW17; -. DR Ensembl; ENSCJAT00000007063; ENSCJAP00000006690; ENSCJAG00000035381. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 222 245 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 141 213 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 277 AA; 31067 MW; B5A2D3E5841DF47A CRC64; MGGRGEPRAP WMEQEGPEYW DRETLTLRAS AQTHRGNLRT LRGYYNQSEA GSHTLQTTYG CDLGPDGRLF RGYYQHAYDD KDYIALNEDL RSWTAADTAA QITQRKAYLE GTCLKWLRRY LAKGKETATH VTHHPVSDHE ATLRCWALGF YPVEITLTWQ KDGEDQTQDA ELVETRPAGD GTFQKWTAVV VPSGEEQGYM CHVQHKGLPK PLTLRWEPSS QLTIPIVGIV ADLVFFGAVV IGAVVTAMMW RRKSSGSDSA QDSDVSLTAC KGEILRV // ID H9KW18_CALJA Unreviewed; 361 AA. AC H9KW18; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000006695}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000006695, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000006695} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000006695} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSCJAT00000007069; ENSCJAP00000006695; ENSCJAG00000017426. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 361 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015326955. FT TRANSMEM 303 328 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 361 AA; 40536 MW; 6BBC40459DEA622D CRC64; MAPRTLLLLL SGALALTETW AGSHSMRYFS TAVSRPGRGE PRYIEVGYVD DTQFVRFDSD AASPRMEPRA PWVEQEGPEY WDEETRRAKT LAQTFRGNLR TALGYYNQTD AGSHTIQWMS GCDVGPDGRL LRGYNQFAYD GKDYIALNED LRSWTAADVA AQITQRKWEA ANEAERRRAY LEGTCVEWLR RYLENGKETL QRAEPPKTHV THHPVSDHEA TLRCWALGFY PAEITLTWQR DGEDQTQDME LVETRPAGDR TFQKWAAVVV LSGEERRYTC HVHHEGLPEP LTLRWEPPSQ PTIPIMGIVA ALAILGAVTG AVVVAVMWRK KSSDKKGGSY SQAARSDSAQ GSDVSLTACK V // ID H9KW27_CALJA Unreviewed; 469 AA. AC H9KW27; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 38. DE SubName: Full=Major histocompatibility complex, class I, F {ECO:0000313|Ensembl:ENSCJAP00000007090}; GN Name=HLA-F {ECO:0000313|Ensembl:ENSCJAP00000007090}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000007090, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000007090} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000007090} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9KW27; -. DR STRING; 9483.ENSCJAP00000007090; -. DR Ensembl; ENSCJAT00000007490; ENSCJAP00000007090; ENSCJAG00000040213. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9KW27; -. DR OMA; WMEREGR; -. DR OrthoDB; EOG091G0DR2; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0009986; C:cell surface; IEA:Ensembl. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0046978; F:TAP1 binding; IEA:Ensembl. DR GO; GO:0046979; F:TAP2 binding; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 427 449 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 330 418 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 469 AA; 53107 MW; A61AE9A3ADBDBB18 CRC64; MRRLSPWFLS LGAKAQGAPE THPAQQEEVR VKSQRPRRGS QWLRSGVGRL SVWGFPISTA FFLPNSCRVL LSDTQDADTH DVYPVPTPIG CRVSREANQR RRGPDSKVPT HPRGLRFSPN TEDGVMAPRT LLLLLSGALA LAETQAGSHS LRYLSTAVSR PGRGESRYRY IAVGYVDDTQ FMRFDSDAQS PMMEPRAPWV EQERPEYWDR EVKESAQTDR VNLRILLRYY NQSETGSHTL QGMNGCDVGP DGRFLRGYHQ HAYDGKDYIS LNEDLRSWTA ADTAAQITQR KWEAEKYAEE FSTYLKGACV EWLHRYLENG KETLQRTDPP KAHVAHHPIS DHEATLRCWA LGFYPVEIML TWQRDGEDQT QDTELVETRP AGDGTFQKWA AVVVLSGEEE RYTCHVQHEG LPEPLTLRWE PSSQPTILIV GIVAGLVVLG AVVTGAVMWS KKIWLGRDGN RERYSQAAM // ID H9KW37_CALJA Unreviewed; 330 AA. AC H9KW37; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 12-SEP-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000007499}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000007499, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000007499} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000007499} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9KW37; -. DR STRING; 9483.ENSCJAP00000007499; -. DR Ensembl; ENSCJAT00000007924; ENSCJAP00000007499; ENSCJAG00000035381. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9KW37; -. DR OMA; PTITIMG; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 330 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015361699. FT TRANSMEM 284 312 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 203 275 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 330 AA; 37036 MW; AFB920D6FA65D084 CRC64; MAPRILLLLL SGALVLTKTW AGSHYMRYFC TAVSWPGRGE PRFISAGYVD DTQFVRFDSD AASGRGEPRA PWMEQEGPEY WDRETLTLRA SAQTHRGNLR TLRGYYNQSE AGSHTLQTTY GCDLGPDGRL FRGYYQHAYD DKDYIALNED LRSWTAADTA AQITQRKLAY LEGTCLKWLR RYLAKGKETA THVTHHPVSD HEATLRCWAL GFYPVEITLT WQKDGEDQTQ DAELVETRPA GDGTFQKWTA VVVPSGEEQG YMCHVQHKGL PKPLTLRWEP SSQLTIPIVG IVADLVFFGA VVIGAVVTAM MWRRKSSAGK RGSYSQAACT // ID H9KWK7_CALJA Unreviewed; 242 AA. AC H9KWK7; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000017031}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000017031, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000017031} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000017031} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9KWK7; -. DR STRING; 9483.ENSCJAP00000017031; -. DR Ensembl; ENSCJAT00000018008; ENSCJAP00000017031; ENSCJAG00000009297. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9KWK7; -. DR OMA; ECAWIGS; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 182 208 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 88 175 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 242 AA; 26413 MW; 30B56822D0C6FDC8 CRC64; MYGCDVGPEG RFLRGYRQDA YDGKDYIALN EDLRSWTAAD MAAQIIKNKL EAANEAERMT AYLEGTCVKW LLRHLQNGKE TLQRADPPKT HVTHHPVSDH EATLRCALGF YPAEITLTWQ RDGEDQTQDT ELVETRPAGD GTFPKWAAVV VPSGEEQRYT CHVQHEGLLE PLTLRWEPSS QLTIPIMGIV AGLAVLGAVV IGAVVIAVMQ RRKSSGGKGG SYSQAAGSNS AQGSDVSLMA CK // ID H9KWP5_CALJA Unreviewed; 361 AA. AC H9KWP5; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000019786}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000019786, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000019786} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000019786} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSCJAT00000020912; ENSCJAP00000019786; ENSCJAG00000047963. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 361 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015323094. FT TRANSMEM 303 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 361 AA; 40568 MW; FA4BCF61F165D195 CRC64; MAPRTLLLLL SGALALTETW AGSHSMRYFS TAVSRPGRGE PRFIIVGYVD DTQFVRFDSD AANPRMEPRA PWVEQEGPEY WEEQTRRAKA IAQIDRVDLR TLRGYYNQSD AGSHTIQWMS GCDVGPDGRL LRGYRQDAYD GKDYIALNED LRSWTAADMA AQITQRKWEA ANAAEEMRAY LEGECLEWLH RYLENAKETL QRAEPPKTHV THHPVSDHEA TLRCWALGFY PAEITLTWQR DGEDQTQDME LVETRPTGDR TFQKWAAVVV PSGEEHRYTC HMQHEGLPEP LTLRWEPPSQ PTIPIMGIVA ALAILGAVGG AVVVAVMWRK KSSDKKGGSY SQVASSNSAQ DSDVSLTACK V // ID H9KWV6_CALJA Unreviewed; 104 AA. AC H9KWV6; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000021979}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000021979, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000021979} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000021979} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSCJAT00000023232; ENSCJAP00000021979; ENSCJAG00000047727. DR GeneTree; ENSGT00900000141162; -. DR Proteomes; UP000008225; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 104 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015330882. FT DOMAIN 22 104 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 104 AA; 12543 MW; 5BE8618DAE7F422B CRC64; MEHRTLLLLL SGALFLTETW AGSHSLRYFY TAVSWPRGEP HFIYVGYVDD TQFVRFDSDD PSLRMETRAP WVEQEGPEYW DWETRIVKAH AQNFRMNLRN LRRY // ID H9KWX9_CALJA Unreviewed; 365 AA. AC H9KWX9; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 41. DE SubName: Full=Major histocompatibility complex, class I, E {ECO:0000313|Ensembl:ENSCJAP00000023496}; GN Name=HLA-E {ECO:0000313|Ensembl:ENSCJAP00000023496}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000023496, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000023496} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000023496} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSCJAT00000024856; ENSCJAP00000023496; ENSCJAG00000042967. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015323108. FT TRANSMEM 306 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 40912 MW; AA80D20199256161 CRC64; DGVMSPRSLL LLLSGALALT DTWASSHSLR YFHTSVSRPG RGEPHFISVG YVDDTQFVRF DSDAAIPRME PRAPWMEQQG QEYWDRETRS ARDTAQSFRV NLRTLLRYYN QSEAGSHTLQ WLHGCDVGPD GRFLRGYEQF AYDGKDYLTL NEDLRSWTAA DTAAQISQRK SEEACEAEHQ RAYLEDTCVE WLRRYLENGK ETLQRAEPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ DMELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL REPLTLRWEP SSQPTIPIVG IVVGLAVLGA VVTGAVVAAV MQKKKSLGEE GVRGNDSAQG SDVSLTGCKG ETLGV // ID H9KWY3_CALJA Unreviewed; 362 AA. AC H9KWY3; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 40. DE SubName: Full=Major histocompatibility complex, class I, E {ECO:0000313|Ensembl:ENSCJAP00000023937}; GN Name=HLA-E {ECO:0000313|Ensembl:ENSCJAP00000023937}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000023937, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000023937} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000023937} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSCJAT00000025322; ENSCJAP00000023937; ENSCJAG00000042967. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015350931. FT TRANSMEM 303 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40625 MW; 08F36010EBAAAB24 CRC64; MSPRSLLLLL SGALALTDTW ASSHSLRYFH TSVSRPGRGE PHFISVGYVD DTQFVRFDSD AAIPRMEPRA PWMEQQGQEY WDRETRSARD TAQSFRVNLR TLLRYYNQSE AGSHTLQWLH GCDVGPDGRF LRGYEQFAYD GKDYLTLNED LRSWTAADTA AQISQRKSEE ACEAEHQRAY LEDTCVEWLR RYLENGKETL QRAEPPKTHV THHPVSDHEA TLRCWALGFY PAEITLTWQW DGEDQTQDME LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLREP LTLRWEPSSQ PTIPIVGIVV GLAVLGAVVT GAVVAAVMQK KKSLGGKGGS YFQAACNDSA QGSDVSLTGC KV // ID H9KWY6_CALJA Unreviewed; 262 AA. AC H9KWY6; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 12-SEP-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000023962}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000023962, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000023962} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000023962} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9KWY6; -. DR Ensembl; ENSCJAT00000025347; ENSCJAP00000023962; ENSCJAG00000018186. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 262 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015310503. FT TRANSMEM 208 236 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 113 211 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 262 AA; 29407 MW; 8E340B78192472FE CRC64; MAVLAPRTLL LLLLGALAQT KTWAGSHFMR YFHIAVSRPG RGEPRYLEVG YVDDTQFVRF DSDAMEPRAP WVEQEGPEYW EEETQRAKDV AQTFRVNLQT LRGYYNQSGA DPPKTHVTHH PISDHEAILR CWAMGFYAAE ITLTWQRDGE DQTQDMELVE TRPAGDGNFQ KWAAVVVPSG EEQRYMCHVQ HEGLLEPLTL RWEPSSQLTI SIVGIVAGLV VLGAVVIGAM VTAVMWRKKS SGREGMKRGL GFLVPLGVSS PR // ID H9KXB3_CALJA Unreviewed; 359 AA. AC H9KXB3; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000032185}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000032185, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000032185} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000032185} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSCJAT00000034023; ENSCJAP00000032185; ENSCJAG00000043681. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 359 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015320212. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 40624 MW; AF1EA4FE5420158B CRC64; MTVMAPRTLL LLLSGALALT ETGAGSHSMR YFSTAVSRPG RGEPRYIEVG YVDDTQFVRF DSDAASPRME PRAPWVEQEG PEYWEEQTRN AKTHAQTDRV NLRTLRGYYN QTDAGSHTFQ VMYGCDVGPD GRLLRGYDQY AYDGKDYIAL NEDLRSWTAA DVAAQITQRK WEAANEAERI RAYLEGTCLE WLRRYLENGK ETLQRAEPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DMELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHMQHEGL PEPLTLRWEP PSQPTIPIMG IVTALAILGT VAGAVVVAVM WRKKSSGEEG QSYSRGARLL EGTVRNRKK // ID H9KXC9_CALJA Unreviewed; 356 AA. AC H9KXC9; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000033676}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000033676, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000033676} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000033676} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9483.ENSCJAP00000033676; -. DR Ensembl; ENSCJAT00000035576; ENSCJAP00000033676; ENSCJAG00000048240. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9KXC9; -. DR OMA; VPGYYNQ; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 356 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015327868. FT TRANSMEM 303 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 356 AA; 39907 MW; 6E4C3258346091D2 CRC64; MAPRTLLLLL SAAMALTETW AGSHSLRYFQ TAVSRSGSRE PHFFAVGYVD DTQFERFDSD AAIPRGEPRT PWMELEGPEY WDLQTRTLKA RAQTNQVCLR TLRGYYNQSE AGSHIYQRMY GCDLGPDGRL LRGYDKRAYD GKDYLALNED LRSWTAADRA AQVTQRKFEA AHEAEKMKAY LEGTCVESLR RYLENGKERL QRADPPKTHV AHHPISDQEA TLRCWALGFY PAEITLTWQR DGEDQTQDTE FVETRPSGDG TFQKWVAVVV PSGEEQRYTC HVQHEGLLEP LTLRWEPSSQ PTIHIMGIIA GLAVLGAVVT GAVVTAVIWR SLSSGSDSTQ GSDVSLTTCK GEIVGI // ID H9KXJ1_CALJA Unreviewed; 368 AA. AC H9KXJ1; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 12-SEP-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000036350}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000036350, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000036350} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000036350} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9483.ENSCJAP00000036350; -. DR Ensembl; ENSCJAT00000038389; ENSCJAP00000036350; ENSCJAG00000019566. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9KXJ1; -. DR OMA; LENICVQ; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 368 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015314314. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 40876 MW; 44890EFDCA5D848E CRC64; MAVVTPRTLL LLLSGALALT ETWAGSHSLR YFDTAVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASGRGE PRAPWMEQEG SEYWEERTMS YKAQAQSSRL CLKLLPGHYN QSEARSHTYQ RMYGCEVGPD GRFLRGFYQS AYDGKDYLAL NEDLSSLIAA DTEAQITQRK WEAANLAEGW RAYLEGKCVE LLRRYLENGK ETLQRADPPK TRVTHHPISD HEATLRCWAL GFYPAEITLT WQQDGEDQTQ DTELVETRPS GDGTFQKWAA VVVPSGEEQR YTCHVQHKGL PEPLTLRWEP SSQPTIPIVG IVAGLILLGA VVTGAVVAAV MWRRKSSGRE GVRSGACSES ARGSDVSLTA CKGEVLEV // ID H9KXM2_CALJA Unreviewed; 364 AA. AC H9KXM2; M9ZP22; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 12-SEP-2018, entry version 45. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:AGK36261.1}; DE SubName: Full=MHC class I protein {ECO:0000313|EMBL:SPM26442.1}; GN Name=Caja-G {ECO:0000313|EMBL:SPM26442.1}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000038437, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000038437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000038437} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. RN [4] {ECO:0000313|EMBL:AGK36261.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=IA6-07 {ECO:0000313|EMBL:AGK36261.1}; RA Sun Z.Z., Li A.X., Zeng L., Cao Y.H.; RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:SPM26442.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Enwor {ECO:0000313|EMBL:SPM26442.1}; RA Keele B.F.; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KC510687; AGK36261.1; -; mRNA. DR EMBL; LT992523; SPM26442.1; -; mRNA. DR STRING; 9483.ENSCJAP00000038437; -. DR Ensembl; ENSCJAT00000040606; ENSCJAP00000038437; ENSCJAG00000043365. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9KXM2; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015390993. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 40867 MW; 71E5AE5791B0F5AE CRC64; MTVMAPRTLL LLLSGALALT ETWAGSHSMR YFHTAMSRPG RGEPRFIIVG YVDDTQFVRF DSDAASPRME PRAPWVEQEG PEYWDEETRK AKANAQIDRV DLQTLRGYYN QTDAGSHTIQ WMSGCDVGPD GRLLRGYRQD AYDGKDYIAL NEDLRSWTAA DVAAQITQRK WEAANVAERR RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DMELIETRPA GDRTFQKWAA VVVLSGEEHR YTCHVQHEGL PEPLTLRWEP SSQPTIPIMG IVAALAILGA LAGAVVAAVM WRKKSSDKKG GSYSQAARSE SAQGSDVSLT ACKV // ID H9KY30_CALJA Unreviewed; 333 AA. AC H9KY30; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 12-SEP-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000044669}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000044669, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000044669} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000044669} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H9KY30; -. DR STRING; 9483.ENSCJAP00000044669; -. DR Ensembl; ENSCJAT00000057988; ENSCJAP00000044669; ENSCJAG00000039652. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9KY30; -. DR OMA; AYLEENC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 333 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015349939. FT TRANSMEM 273 300 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 177 263 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 131 151 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 333 AA; 37047 MW; EC459DE55B718AD9 CRC64; MAPRTLLLLL SGTLALTKTS ASSHSLYGFF STVSRPGRGE PRFIGVGYVD DTQFMRFDSD AAVPRMEPRA PWAEQEGPEY WDGLTRRAKA CAQACRVSLR DIRGYYNQSE DGKDHVTLNE DLRSWTAADT VAEFTQRKLE AEKYAEQLRA ELQGECVERL KRFLENGKEK LQRAEPPKTH VTHHSITDHE ATLRCWALGF YPAEITLTWQ RDGEEQTQDT ELVETRPAGD GTFQKWAAVV VPSGEEQRYT CHVQHEGLPE PLSLRWEPPS QPIIPIVSIV AGLAVLASVV TGAVVTAVMW RRKSSGREGV RGSDSAQGSD VSLTVCKGEF LGV // ID H9KYD9_CALJA Unreviewed; 454 AA. AC H9KYD9; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 18-JUL-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000049333}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000049333, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000049333} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000049333} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSCJAT00000060108; ENSCJAP00000049333; ENSCJAG00000043681. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 396 421 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 299 387 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 454 AA; 50412 MW; A0EC998F6FE0C004 CRC64; MAPGVALTVS DPEGGVWIVE AQPWGFPISA EFLFLSQTVS GPSSWLLTTR TQFPLPLGAG FPEKPISVPA VLVLKSPVTH LESNSPQTPR MTVMAPRTLL LLLSGALALT ETGAGSHSMR YFSTAVSRPG RGEPRYIEVG YVDDTQFVRF DSDAASPRME PRAPWVEQEG PEYWEEQTRN AKTHAQTDRV NLRTLRGYYN QTDAGSHTFQ VMYGCDVGPD GRLLRGYDQY AYDGKDYIAL NEDLRSWTAA DVAAQITQRK WEAANEAERI RAYLEGTCLE WLRRYLENGK ETLQRAEPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DMELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHMQHEGL PEPLTLRWEP PSQPTIPIMG IVTALAILGT VAGAVVVAVM WRKKSSDKKG GSYSQAARSE SAQGSDVSLT ACKV // ID H9KYE8_CALJA Unreviewed; 354 AA. AC H9KYE8; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 12-SEP-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000049603}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000049603, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RT "6.6x PCAP assembly of the genome of Callithrix jacchus."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000049603} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCJAP00000049603} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 9483.ENSCJAP00000049603; -. DR Ensembl; ENSCJAT00000055785; ENSCJAP00000049603; ENSCJAG00000018186. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; H9KYE8; -. DR OMA; CEGETHP; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 354 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015325031. FT TRANSMEM 300 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 303 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 354 AA; 40173 MW; EBC2EDFC5590B7CD CRC64; MAVLAPRTLL LLLLGALAQT KTWAGSHFMR YFHIAVSRPG RGEPRYLEVG YVDDTQFVRF DSDAMEPRAP WVEQEGPEYW EEETQRAKDV AQTFRVNLQT LRGYYNQSGA GSHTLQLMYR CYLGPDWSLL RGYLQFAYDA KDYISLNHDL SSWTAADTAA QITQRKWEAA NVAEEWRAYM EGTCLEWLRR HLKNGKETLQ RADPPKTHVT HHPISDHEAI LRCWAMGFYA AEITLTWQRD GEDQTQDMEL VETRPAGDGN FQKWAAVVVP SGEEQRYMCH VQHEGLLEPL TLRWEPSSQL TISIVGIVAG LVVLGAVVIG AMVTAVMWRK KSSGREGMKR GLGFLVPLGV SSPR // ID H9L3V2_CHICK Unreviewed; 354 AA. AC H9L3V2; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 3. DT 12-SEP-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGALP00000040545}; GN Name=MHCIA4 {ECO:0000313|Ensembl:ENSGALP00000040545}; OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Phasianinae; Gallus. OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000040545, ECO:0000313|Proteomes:UP000000539}; RN [1] {ECO:0000313|Ensembl:ENSGALP00000040545, ECO:0000313|Proteomes:UP000000539} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000040545, RC ECO:0000313|Proteomes:UP000000539}; RX PubMed=15592404; DOI=10.1038/nature03154; RG International Chicken Genome Sequencing Consortium; RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., RA Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., RA Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., RA Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C., RA Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., RA Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., RA Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., RA Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., RA Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., RA Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., RA van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., RA Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., RA Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., RA Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., RA Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., RA Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., RA Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., RA Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., RA King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., RA Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., RA Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., RA Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., RA Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., RA Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., RA Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., RA Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., RA Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., RA Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., RA Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., RA Mardis E.R., Wilson R.K.; RT "Sequence and comparative analysis of the chicken genome provide RT unique perspectives on vertebrate evolution."; RL Nature 432:695-716(2004). RN [2] {ECO:0000313|Ensembl:ENSGALP00000040545} RP IDENTIFICATION. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000040545}; RG Ensembl; RL Submitted (APR-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AADN04000614; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AADN04000615; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSGALT00000041340; ENSGALP00000040545; ENSGALG00000032602. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; H9L3V2; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000000539; Chromosome 16. DR Bgee; ENSGALG00000026466; Expressed in 10 organ(s), highest expression level in heart. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000539}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000539}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 269 289 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 171 258 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 354 AA; 38944 MW; 7FC39B44417DB503 CRC64; MTDPGPGMPQ FVIVGCVDGE LLWNYNSLGR TVRPIMGWLP QEDQEHWDAE TQKARDVELH FYEFLGRLQV HYNKSGGSHT LQKMIGCDIL EDGSIRGYVQ YAFDGRDFLA FDMDTMTFTA ADPVAEITKR RWEEEGIYTE GCKHELGTIC VQNLRRYLEH GKAVLKRRER PEVRVWGKEA NGILTLSCRA YGFYPRRIAI SWMKDGMVRD QETHWGGIVP NSDGTYHASA AIDVLPKDVD KYWCRVEHTS LPQPGLFSWE LQPNLTPSVA GAVGAIVAVI AAVVGVVVWK SKSGKGRGLG GEGVLGGAGG KEKKGYEAAA GECQGQNWQK TASAWGQGTL GPLVASGVTV QVVA // ID HA10_MOUSE Reviewed; 325 AA. AC P01898; O19475; Q31214; Q95HC3; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 06-MAR-2007, sequence version 3. DT 12-SEP-2018, entry version 161. DE RecName: Full=H-2 class I histocompatibility antigen, Q10 alpha chain; DE Flags: Precursor; GN Name=H2-Q10; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6420070; DOI=10.1016/0092-8674(84)90082-5; RA Mellor A.L., Weiss E.H., Kress M., Jay G., Flavell R.A.; RT "A nonpolymorphic class I gene in the murine major histocompatibility RT complex."; RL Cell 36:139-144(1984). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=C3H/HeJ; RX PubMed=2767053; RA Watts S., Davis A.C., Gaut B., Wheeler C., Hill L., Goodenow R.S.; RT "Organization and structure of the Qa genes of the major RT histocompatibility complex of the C3H mouse: implications for Qa RT function and class I evolution."; RL EMBO J. 8:1749-1759(1989). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Liver; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; TISSUE=Liver; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9. RX PubMed=3510743; DOI=10.1016/0092-8674(86)90760-9; RA Kimura A., Israel A., le Bail O., Kourilsky P.; RT "Detailed analysis of the mouse H-2Kb promoter: enhancer-like RT sequences and their role in the regulation of class I gene RT expression."; RL Cell 44:261-272(1986). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] OF 85-325 (CLONE PH16). RX PubMed=6411351; DOI=10.1016/0092-8674(83)90149-6; RA Kress M., Cosman D., Khoury G., Jay G.; RT "Secretion of a transplantation-related antigen."; RL Cell 34:189-196(1983). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 300-325. RX PubMed=2584927; DOI=10.1084/jem.170.6.1837; RA Brorson K.A., Hunt S.W. III, Hunkapiller T., Sun Y.H., Cheroutre H., RA Nickerson D.A., Hood L.; RT "Comparison of exon 5 sequences from 35 class I genes of the BALB/c RT mouse."; RL J. Exp. Med. 170:1837-1858(1989). RN [8] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110 AND ASN-280. RC STRAIN=C57BL/6J; TISSUE=Plasma; RX PubMed=17330941; DOI=10.1021/pr0604559; RA Bernhard O.K., Kapp E.A., Simpson R.J.; RT "Enhanced analysis of the mouse plasma proteome using cysteine- RT containing tryptic glycopeptides."; RL J. Proteome Res. 6:987-995(2007). RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, and Pancreas; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAA39574.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC Sequence=AAA39676.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; K01207; AAA39574.1; ALT_INIT; Genomic_DNA. DR EMBL; K01205; AAA39574.1; JOINED; Genomic_DNA. DR EMBL; X16426; CAA34449.1; -; Genomic_DNA. DR EMBL; AK131620; BAE20725.1; -; mRNA. DR EMBL; BC011215; AAH11215.1; -; mRNA. DR EMBL; M12484; AAA39676.1; ALT_INIT; Genomic_DNA. DR EMBL; K00614; AAA39681.1; -; mRNA. DR EMBL; X16206; CAA34326.1; -; Genomic_DNA. DR CCDS; CCDS37599.1; -. DR PIR; A02199; HLMSTR. DR PIR; A21125; A21125. DR PIR; S20045; S20045. DR RefSeq; NP_034521.1; NM_010391.4. DR UniGene; Mm.88795; -. DR PDB; 5J6G; X-ray; 3.30 A; A/C=25-280. DR PDB; 5J6H; X-ray; 2.30 A; A=25-325. DR PDBsum; 5J6G; -. DR PDBsum; 5J6H; -. DR ProteinModelPortal; P01898; -. DR SMR; P01898; -. DR BioGrid; 200177; 1. DR STRING; 10090.ENSMUSP00000066419; -. DR iPTMnet; P01898; -. DR PhosphoSitePlus; P01898; -. DR EPD; P01898; -. DR MaxQB; P01898; -. DR PaxDb; P01898; -. DR PeptideAtlas; P01898; -. DR PRIDE; P01898; -. DR Ensembl; ENSMUST00000068291; ENSMUSP00000066419; ENSMUSG00000067235. DR Ensembl; ENSMUST00000174525; ENSMUSP00000134163; ENSMUSG00000067235. DR GeneID; 15007; -. DR KEGG; mmu:15007; -. DR UCSC; uc008cht.1; mouse. DR CTD; 15007; -. DR MGI; MGI:95929; H2-Q10. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; P01898; -. DR KO; K06751; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G09OH; -. DR PhylomeDB; P01898; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; H2-Q10; mouse. DR PRO; PR:P01898; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000067235; Expressed in 101 organ(s), highest expression level in liver. DR CleanEx; MM_H2-Q10; -. DR Genevisible; P01898; MM. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI. DR GO; GO:0005615; C:extracellular space; IDA:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; ISO:MGI. DR GO; GO:0042277; F:peptide binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0046977; F:TAP binding; ISO:MGI. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000255}. FT CHAIN 25 325 H-2 class I histocompatibility antigen, FT Q10 alpha chain. FT /FTId=PRO_0000018936. FT TOPO_DOM 25 310 Extracellular. {ECO:0000255}. FT TRANSMEM 311 324 Helical. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 310 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:17330941}. FT CARBOHYD 280 280 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:17330941}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT CONFLICT 99 99 H -> R (in Ref. 4; AAH11215). FT {ECO:0000305}. FT CONFLICT 108 108 Y -> H (in Ref. 1; AAA39574). FT {ECO:0000305}. FT STRAND 27 36 {ECO:0000244|PDB:5J6H}. FT TURN 39 41 {ECO:0000244|PDB:5J6H}. FT STRAND 45 52 {ECO:0000244|PDB:5J6H}. FT STRAND 55 61 {ECO:0000244|PDB:5J6H}. FT STRAND 64 66 {ECO:0000244|PDB:5J6H}. FT STRAND 70 73 {ECO:0000244|PDB:5J6H}. FT TURN 74 78 {ECO:0000244|PDB:5J6H}. FT HELIX 81 108 {ECO:0000244|PDB:5J6H}. FT STRAND 118 127 {ECO:0000244|PDB:5J6H}. FT STRAND 133 142 {ECO:0000244|PDB:5J6H}. FT STRAND 145 150 {ECO:0000244|PDB:5J6H}. FT STRAND 157 159 {ECO:0000244|PDB:5J6H}. FT HELIX 162 173 {ECO:0000244|PDB:5J6H}. FT HELIX 176 185 {ECO:0000244|PDB:5J6H}. FT HELIX 187 198 {ECO:0000244|PDB:5J6H}. FT HELIX 200 203 {ECO:0000244|PDB:5J6H}. FT STRAND 210 218 {ECO:0000244|PDB:5J6H}. FT STRAND 222 235 {ECO:0000244|PDB:5J6H}. FT STRAND 238 243 {ECO:0000244|PDB:5J6H}. FT STRAND 246 248 {ECO:0000244|PDB:5J6G}. FT STRAND 261 263 {ECO:0000244|PDB:5J6H}. FT STRAND 265 274 {ECO:0000244|PDB:5J6H}. FT HELIX 278 280 {ECO:0000244|PDB:5J6H}. FT STRAND 281 286 {ECO:0000244|PDB:5J6H}. FT STRAND 294 296 {ECO:0000244|PDB:5J6H}. SQ SEQUENCE 325 AA; 37251 MW; 82B8B7B9140CD72A CRC64; MGAMAPRTLL LLLAAALAPT QTQAGSHSMR YFETSVSRPG LGEPRFIIVG YVDDTQFVRF DSDAETPRME PRAPWMEQEG PEYWERETQR AKGNEQSFHV SLRTLLGYYN QSESGSHTIQ WMYGCKVGSD GRFLRGYLQY AYDGRDYIAL NEDLKTWTAA DVAAIITRRK WEQAGAAEYY RAYLEAECVE WLLRYLELGK ETLLRTDPPK THVTHHPGSE GDVTLRCWAL GFYPADITLT WQLNGEELTQ DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCHVYHEGL PEPLTLRWEP PPSTDSIMSH IADLLWPSLK LWWYL // ID HA11_MOUSE Reviewed; 362 AA. AC P01899; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 2. DT 12-SEP-2018, entry version 183. DE RecName: Full=H-2 class I histocompatibility antigen, D-B alpha chain; DE Short=H-2D(B); DE Flags: Precursor; GN Name=H2-D1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=C3H/HeJ; RX PubMed=3680952; RA Watts S., Vogel J.M., Harriman W.D., Itoh T., Stauss H.J., RA Goodenow R.S.; RT "DNA sequence analysis of the C3H H-2Kk and H-2Dk loci. Evolutionary RT relationships to H-2 genes from four other mouse strains."; RL J. Immunol. 139:3878-3885(1987). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=NOD/LT; RA Girgis K.R., Capra D.J., Stroynowski I.; RL Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=C57BL/10; RX PubMed=9869916; RA Wang M., Stepkowski S.M., Hebert J.S., Tian L., Yu J., Kahan B.D.; RT "Nucleotide sequences of three H-2K and three H-2D complementary DNA RT clones coding mouse class I MHC heavy chain proteins."; RL Ann. Transplant. 1:26-31(1996). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] OF 105-362. RX PubMed=7118211; DOI=10.1007/BF00364437; RA Reyes A.A., Schold M., Wallace R.B.; RT "The complete amino acid sequence of the murine transplantation RT antigen H-2Db as deduced by molecular cloning."; RL Immunogenetics 16:1-9(1982). RN [5] RP PROTEIN SEQUENCE OF 25-122. RX PubMed=7225204; RA Maloy W.L., Nathenson S.G., Coligan J.E.; RT "Primary structure of murine major histocompatibility complex RT alloantigens. Amino acid sequence of the NH2-terminal ninety-eight RT residues of the H-2Db glycoprotein."; RL J. Biol. Chem. 256:2863-2872(1981). RN [6] RP PROTEIN SEQUENCE OF 253-308 AND 332-358. RX PubMed=7118212; DOI=10.1007/BF00364438; RA Maloy W.L., Coligan J.E.; RT "Primary structure of the H-2Db alloantigen. II. Additional amino acid RT sequence information, localization of a third site of glycosylation RT and evidence for K and D region specific sequences."; RL Immunogenetics 16:11-22(1982). RN [7] RP GLYCOSYLATION AT ASN-110 AND ASN-280. RX PubMed=3980466; RA Swiedler S.J., Freed J.H., Tarentino A.L., Plummer T.H. Jr., RA Hart G.W.; RT "Oligosaccharide microheterogeneity of the murine major RT histocompatibility antigens. Reproducible site-specific patterns of RT sialylation and branching in asparagine-linked oligosaccharides."; RL J. Biol. Chem. 260:4046-4054(1985). RN [8] RP UBIQUITINATION, INTERACTION WITH MURID HERPESVIRUS 4 K3, AND RP MUTAGENESIS OF LYS-55; LYS-92; LYS-155; LYS-170; LYS-197; LYS-210; RP LYS-220; LYS-267; LYS-277; LYS-332; THR-337; LYS-340; 350-SER--SER-356 RP AND 360-CYS-LYS-361. RX PubMed=17502423; DOI=10.1083/jcb.200611063; RA Wang X., Herr R.A., Chua W.J., Lybarger L., Wiertz E.J., Hansen T.H.; RT "Ubiquitination of serine, threonine, or lysine residues on the RT cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3."; RL J. Cell Biol. 177:613-624(2007). RN [9] RP UBIQUITINATION AT SER-353, INTERACTION WITH MURID HERPESVIRUS 4 K3, RP AND MUTAGENESIS OF LYS-332; THR-337; LYS-340; 350-SER--SER-352; RP SER-356 AND 360-CYS-LYS-361. RX PubMed=19951915; DOI=10.1083/jcb.200908036; RA Wang X., Herr R.A., Rabelink M., Hoeben R.C., Wiertz E.J., RA Hansen T.H.; RT "Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated RT degradation substrates."; RL J. Cell Biol. 187:655-668(2009). RN [10] RP UBIQUITINATION, INTERACTION WITH MURID HERPESVIRUS 4 K3, AND RP MUTAGENESIS OF LYS-332; THR-337; LYS-340; 350-SER--SER-352; SER-356 RP AND 360-CYS-LYS-361. RX PubMed=19531064; DOI=10.1111/j.1600-0854.2009.00946.x; RA Herr R.A., Harris J., Fang S., Wang X., Hansen T.H.; RT "Role of the RING-CH domain of viral ligase mK3 in ubiquitination of RT non-lysine and lysine MHC I residues."; RL Traffic 10:1301-1317(2009). RN [11] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 25-296. RX PubMed=7506996; DOI=10.1016/0092-8674(94)90171-6; RA Young A.C.M., Zhang W., Sacchettini J.C., Nathenson S.G.; RT "The three-dimensional structure of H-2Db at 2.4-A resolution: RT implications for antigen-determinant selection."; RL Cell 76:39-50(1994). RN [12] RP X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 24-304, AND DISULFIDE BONDS. RX PubMed=10993729; DOI=10.1006/jmbi.2000.4501; RA Tissot A.C., Ciatto C., Mittl P.R., Grutter M.G., Pluckthun A.; RT "Viral escape at the molecular level explained by quantitative T-cell RT receptor/peptide/MHC interactions and the crystal structure of a RT peptide/MHC complex."; RL J. Mol. Biol. 302:873-885(2000). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). Interacts with murid herpesvirus 4 protein K3 CC (mK3). {ECO:0000269|PubMed:17502423, ECO:0000269|PubMed:19531064, CC ECO:0000269|PubMed:19951915}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in case of infection by murid herpesvirus CC 4, by the viral E3 ligase K3 (mK3). This modification causes the CC protein to be targeted for rapid degradation by the endoplasmic CC reticulum-associated degradation (ERAD) system. Ubiquitination CC occurs on lysine, as well as serine and threonine residues present CC in the cytoplasmic tail. Serine and threonine residues are subject CC to ubiquitination via ester bonds instead of the usual isopeptide CC linkage. {ECO:0000269|PubMed:17502423, CC ECO:0000269|PubMed:19531064, ECO:0000269|PubMed:19951915}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAA39580.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M18523; AAA53200.1; -; Genomic_DNA. DR EMBL; L36068; AAA89206.1; -; mRNA. DR EMBL; U47325; AAB17603.1; -; mRNA. DR EMBL; K00129; AAA39580.1; ALT_INIT; mRNA. DR CCDS; CCDS57074.1; -. DR PIR; B60854; B60854. DR PIR; I56002; HLMSDB. DR RefSeq; NP_034510.3; NM_010380.3. DR UniGene; Mm.439675; -. DR PDB; 1BZ9; X-ray; 2.80 A; A=26-299. DR PDB; 1CE6; X-ray; 2.90 A; A=25-298. DR PDB; 1FFN; X-ray; 2.70 A; A/D=26-298. DR PDB; 1FFO; X-ray; 2.65 A; A/D=26-298. DR PDB; 1FFP; X-ray; 2.60 A; A/D=26-298. DR PDB; 1FG2; X-ray; 2.75 A; A/D/G/J=25-304. DR PDB; 1HOC; X-ray; 2.40 A; A=25-296. DR PDB; 1INQ; X-ray; 2.20 A; A=25-299. DR PDB; 1JPF; X-ray; 2.18 A; A=25-304. DR PDB; 1JPG; X-ray; 2.20 A; A=25-304. DR PDB; 1JUF; X-ray; 2.00 A; A=25-299. DR PDB; 1N3N; X-ray; 3.00 A; A/C/E/G=25-304. DR PDB; 1N5A; X-ray; 2.85 A; A/D/G/J=25-300. DR PDB; 1QLF; X-ray; 2.65 A; A=25-300. DR PDB; 1S7U; X-ray; 2.20 A; A/D/G/J=25-362. DR PDB; 1S7V; X-ray; 2.20 A; A/D=25-362. DR PDB; 1S7W; X-ray; 2.40 A; A/D/G/J=25-362. DR PDB; 1S7X; X-ray; 2.41 A; A/D/G/J=25-362. DR PDB; 1WBX; X-ray; 1.90 A; A=25-300. DR PDB; 1WBY; X-ray; 2.30 A; A=25-300. DR PDB; 1YN6; X-ray; 2.20 A; A=26-298. DR PDB; 1YN7; X-ray; 2.20 A; A=26-298. DR PDB; 1ZHB; X-ray; 2.70 A; A/D/G/J=25-300. DR PDB; 2CII; X-ray; 2.55 A; A=25-299. DR PDB; 2F74; X-ray; 2.70 A; A/D=25-300. DR PDB; 2VE6; X-ray; 2.65 A; A/D/G/J=25-301. DR PDB; 2ZOK; X-ray; 2.10 A; A/C/E/G=25-299. DR PDB; 2ZOL; X-ray; 2.70 A; A/C=25-299. DR PDB; 3BUY; X-ray; 2.60 A; A=26-300. DR PDB; 3CC5; X-ray; 1.91 A; A/D=25-300. DR PDB; 3CCH; X-ray; 2.60 A; A/D/G/J=25-300. DR PDB; 3CH1; X-ray; 2.30 A; A/D/G/J=25-300. DR PDB; 3CPL; X-ray; 2.50 A; A/C=25-299. DR PDB; 3FTG; X-ray; 2.60 A; A=25-304. DR PDB; 3L3H; X-ray; 2.70 A; A=26-300. DR PDB; 3PQY; X-ray; 3.19 A; A/F/K/P=26-300. DR PDB; 3QUK; X-ray; 2.41 A; A/D=25-362. DR PDB; 3QUL; X-ray; 2.00 A; A/D/G/J=25-362. DR PDB; 3TBS; X-ray; 2.49 A; A/D=25-362. DR PDB; 3TBT; X-ray; 2.30 A; A/D/G/J=25-362. DR PDB; 3TBV; X-ray; 2.10 A; A/C/E/G=25-362. DR PDB; 3TBW; X-ray; 2.15 A; A/C/E/G=25-362. DR PDB; 3TBY; X-ray; 2.50 A; A/D/G/J=25-362. DR PDB; 3WS3; X-ray; 2.34 A; A/C=26-298. DR PDB; 3WS6; X-ray; 1.98 A; A/B=26-300. DR PDB; 4HUU; X-ray; 2.00 A; A/D=25-304. DR PDB; 4HUV; X-ray; 2.50 A; A/D=25-304. DR PDB; 4HUW; X-ray; 3.16 A; A/C/E/G=25-304. DR PDB; 4HUX; X-ray; 2.20 A; A=25-304. DR PDB; 4HV8; X-ray; 2.00 A; A/C=25-304. DR PDB; 4IHO; X-ray; 2.80 A; A/D=25-300. DR PDB; 4L8B; X-ray; 2.20 A; A=25-304. DR PDB; 4L8C; X-ray; 2.80 A; A/C/E/G=25-304. DR PDB; 4L8D; X-ray; 1.90 A; A/C=25-304. DR PDB; 4NSK; X-ray; 2.60 A; A=25-300. DR PDB; 4PG2; X-ray; 2.80 A; A=25-299. DR PDB; 5E8N; X-ray; 2.25 A; A/D/G/J=25-300. DR PDB; 5E8O; X-ray; 1.98 A; A/D=25-300. DR PDB; 5E8P; X-ray; 2.00 A; A/D=25-300. DR PDB; 5JWD; X-ray; 2.50 A; A=25-298. DR PDB; 5JWE; X-ray; 2.40 A; A/C/E/G=25-300. DR PDB; 5M00; X-ray; 1.95 A; A=25-300. DR PDB; 5M01; X-ray; 1.95 A; A=25-300. DR PDB; 5M02; X-ray; 1.75 A; A=25-300. DR PDB; 5MZM; X-ray; 2.40 A; A/D=25-300. DR PDB; 5OPI; X-ray; 3.30 A; A=25-300. DR PDB; 5SWS; X-ray; 2.86 A; A=25-304. DR PDB; 5SWZ; X-ray; 2.65 A; A/F/K/P=25-304. DR PDB; 5TIL; X-ray; 2.83 A; A/D=25-300. DR PDB; 5TJE; X-ray; 3.20 A; A/C=25-300. DR PDB; 5WLG; X-ray; 2.10 A; A/F=25-302. DR PDB; 5WLI; X-ray; 2.20 A; A/D/G/J=25-302. DR PDBsum; 1BZ9; -. DR PDBsum; 1CE6; -. DR PDBsum; 1FFN; -. DR PDBsum; 1FFO; -. DR PDBsum; 1FFP; -. DR PDBsum; 1FG2; -. DR PDBsum; 1HOC; -. DR PDBsum; 1INQ; -. DR PDBsum; 1JPF; -. DR PDBsum; 1JPG; -. DR PDBsum; 1JUF; -. DR PDBsum; 1N3N; -. DR PDBsum; 1N5A; -. DR PDBsum; 1QLF; -. DR PDBsum; 1S7U; -. DR PDBsum; 1S7V; -. DR PDBsum; 1S7W; -. DR PDBsum; 1S7X; -. DR PDBsum; 1WBX; -. DR PDBsum; 1WBY; -. DR PDBsum; 1YN6; -. DR PDBsum; 1YN7; -. DR PDBsum; 1ZHB; -. DR PDBsum; 2CII; -. DR PDBsum; 2F74; -. DR PDBsum; 2VE6; -. DR PDBsum; 2ZOK; -. DR PDBsum; 2ZOL; -. DR PDBsum; 3BUY; -. DR PDBsum; 3CC5; -. DR PDBsum; 3CCH; -. DR PDBsum; 3CH1; -. DR PDBsum; 3CPL; -. DR PDBsum; 3FTG; -. DR PDBsum; 3L3H; -. DR PDBsum; 3PQY; -. DR PDBsum; 3QUK; -. DR PDBsum; 3QUL; -. DR PDBsum; 3TBS; -. DR PDBsum; 3TBT; -. DR PDBsum; 3TBV; -. DR PDBsum; 3TBW; -. DR PDBsum; 3TBY; -. DR PDBsum; 3WS3; -. DR PDBsum; 3WS6; -. DR PDBsum; 4HUU; -. DR PDBsum; 4HUV; -. DR PDBsum; 4HUW; -. DR PDBsum; 4HUX; -. DR PDBsum; 4HV8; -. DR PDBsum; 4IHO; -. DR PDBsum; 4L8B; -. DR PDBsum; 4L8C; -. DR PDBsum; 4L8D; -. DR PDBsum; 4NSK; -. DR PDBsum; 4PG2; -. DR PDBsum; 5E8N; -. DR PDBsum; 5E8O; -. DR PDBsum; 5E8P; -. DR PDBsum; 5JWD; -. DR PDBsum; 5JWE; -. DR PDBsum; 5M00; -. DR PDBsum; 5M01; -. DR PDBsum; 5M02; -. DR PDBsum; 5MZM; -. DR PDBsum; 5OPI; -. DR PDBsum; 5SWS; -. DR PDBsum; 5SWZ; -. DR PDBsum; 5TIL; -. DR PDBsum; 5TJE; -. DR PDBsum; 5WLG; -. DR PDBsum; 5WLI; -. DR ProteinModelPortal; P01899; -. DR SMR; P01899; -. DR BioGrid; 200150; 3. DR DIP; DIP-6121N; -. DR IntAct; P01899; 2. DR MINT; P01899; -. DR STRING; 10090.ENSMUSP00000134570; -. DR iPTMnet; P01899; -. DR PhosphoSitePlus; P01899; -. DR EPD; P01899; -. DR PaxDb; P01899; -. DR PRIDE; P01899; -. DR Ensembl; ENSMUST00000172785; ENSMUSP00000134570; ENSMUSG00000073411. DR GeneID; 14964; -. DR KEGG; mmu:14964; -. DR UCSC; uc008chg.1; mouse. DR CTD; 14964; -. DR MGI; MGI:95896; H2-D1. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; VPGYYNQ; -. DR OrthoDB; EOG091G09OH; -. DR PhylomeDB; P01899; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; H2-D1; mouse. DR EvolutionaryTrace; P01899; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000073411; Expressed in 296 organ(s), highest expression level in mammary gland. DR CleanEx; MM_H2-D1; -. DR ExpressionAtlas; P01899; baseline and differential. DR Genevisible; P01899; MM. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IDA:MGI. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; ISO:MGI. DR GO; GO:0042277; F:peptide binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0046977; F:TAP binding; ISO:MGI. DR GO; GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IDA:MGI. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0010977; P:negative regulation of neuron projection development; IDA:MGI. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Direct protein sequencing; KW Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I; KW Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 {ECO:0000269|PubMed:7225204}. FT CHAIN 25 362 H-2 class I histocompatibility antigen, FT D-B alpha chain. FT /FTId=PRO_0000018923. FT TOPO_DOM 25 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 331 Helical. {ECO:0000255}. FT TOPO_DOM 332 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT MOD_RES 353 353 Phosphoserine; alternate. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:3980466, FT ECO:0000269|PubMed:7118212}. FT CARBOHYD 200 200 N-linked (GlcNAc...) asparagine. FT {ECO:0000305}. FT CARBOHYD 280 280 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:3980466}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:10993729}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:10993729}. FT CROSSLNK 353 353 Glycyl serine ester (Ser-Gly) (interchain FT with G-Cter in ubiquitin); alternate. FT {ECO:0000305|PubMed:19951915}. FT MUTAGEN 55 55 K->R: In K-less, no effect on FT ubiquitination; when associated with R- FT 92, R-155, R-170, R-197, R-210, R-220, R- FT 267 and R-277. FT {ECO:0000269|PubMed:17502423}. FT MUTAGEN 92 92 K->R: In K-less, no effect on FT ubiquitination; when associated with R- FT 55, R-155, R-170, R-197, R-210, R-220, R- FT 267 and R-277. FT {ECO:0000269|PubMed:17502423}. FT MUTAGEN 155 155 K->R: In K-less, no effect on FT ubiquitination; when associated with R- FT 55, R-92, R-170, R-197, R-210, R-220, R- FT 267 and R-277. FT {ECO:0000269|PubMed:17502423}. FT MUTAGEN 170 170 K->R: In K-less, no effect on FT ubiquitination; when associated with R- FT 55, R-92, R-155, R-197, R-210, R-220, R- FT 267 and R-277. FT {ECO:0000269|PubMed:17502423}. FT MUTAGEN 197 197 K->R: In K-less, no effect on FT ubiquitination; when associated with R- FT 55, R-92, R-155, R-170, R-210, R-220, R- FT 267 and R-277. FT {ECO:0000269|PubMed:17502423}. FT MUTAGEN 210 210 K->R: In K-less, no effect on FT ubiquitination; when associated with R- FT 55, R-92, R-155, R-170, R-197, R-220, R- FT 267 and R-277. FT {ECO:0000269|PubMed:17502423}. FT MUTAGEN 220 220 K->R: In K-less, no effect on FT ubiquitination; when associated with R- FT 55, R-92, R-155, R-170, R-197, R-210, R- FT 267 and R-277. FT {ECO:0000269|PubMed:17502423}. FT MUTAGEN 267 267 K->R: In K-less, no effect on FT ubiquitination; when associated with R- FT 55, R-92, R-155, R-170, R-197, R-210, R- FT 220 and R-277. FT {ECO:0000269|PubMed:17502423}. FT MUTAGEN 277 277 K->R: In K-less, no effect on FT ubiquitination; when associated with R- FT 55, R-92, R-155, R-170, R-197, R-210, R- FT 220 and R-267. FT {ECO:0000269|PubMed:17502423}. FT MUTAGEN 332 332 K->R: In Ld KCST-less, strongly impairs FT ubiquitination; when associated with I- FT 337; R-340; 350-A--A-356 and 360-R-R-361. FT In Ld tail 1S, restores ubiquitination; FT when associated I-337; R-340; 350-A--A- FT 352; A-356 and 360-R-R-361. FT {ECO:0000269|PubMed:17502423, FT ECO:0000269|PubMed:19531064, FT ECO:0000269|PubMed:19951915}. FT MUTAGEN 337 337 T->I: In Ld KCST-less, strongly impairs FT ubiquitination; when associated with R- FT 332; R-340; 350-A--A-356 and 360-R-R-361. FT In Ld tail 1S, restores ubiquitination; FT when associated R-332; R-340; 350-A--A- FT 352; A-356 and 360-R-R-361. FT {ECO:0000269|PubMed:17502423, FT ECO:0000269|PubMed:19531064, FT ECO:0000269|PubMed:19951915}. FT MUTAGEN 340 340 K->R: In Ld KCST-less, strongly impairs FT ubiquitination; when associated with R- FT 332; I-337; 350-A--A-356 and 360-R-R-361. FT In Ld tail 1S, restores ubiquitination; FT when associated R-332; I-337; 350-A--A- FT 352; A-356 and 360-R-R-361. FT {ECO:0000269|PubMed:17502423, FT ECO:0000269|PubMed:19531064, FT ECO:0000269|PubMed:19951915}. FT MUTAGEN 350 356 SQSSEMS->AQGAEMA: In Ld KCST-less, FT strongly impairs ubiquitination; when FT associated with R-332; I-337 and 360-R-R- FT 361. {ECO:0000269|PubMed:17502423}. FT MUTAGEN 350 352 SQS->AQG: In Ld tail 1S, restores FT ubiquitination; when associated R-332; I- FT 337; R-340; A-356 and 360-R-R-361. FT {ECO:0000269|PubMed:19531064, FT ECO:0000269|PubMed:19951915}. FT MUTAGEN 356 356 S->A: In Ld tail 1S, restores FT ubiquitination; when associated R-332; I- FT 337; R-340 and A-356. FT {ECO:0000269|PubMed:19531064, FT ECO:0000269|PubMed:19951915}. FT MUTAGEN 360 361 CK->RR: In Ld KCST-less, strongly impairs FT ubiquitination; when associated with R- FT 332; I-337; R-340 and 350-A--A-356. In Ld FT tail 1S, restores ubiquitination; when FT associated R-332; I-337; R-340; 350-A--A- FT 352; A-356 and 360-R-R-361. FT {ECO:0000269|PubMed:17502423, FT ECO:0000269|PubMed:19531064, FT ECO:0000269|PubMed:19951915}. FT STRAND 27 36 {ECO:0000244|PDB:5M02}. FT STRAND 39 41 {ECO:0000244|PDB:5M02}. FT STRAND 45 52 {ECO:0000244|PDB:5M02}. FT STRAND 55 61 {ECO:0000244|PDB:5M02}. FT STRAND 64 66 {ECO:0000244|PDB:5M02}. FT STRAND 70 73 {ECO:0000244|PDB:3CC5}. FT HELIX 74 78 {ECO:0000244|PDB:5M02}. FT HELIX 81 108 {ECO:0000244|PDB:5M02}. FT STRAND 113 115 {ECO:0000244|PDB:1WBX}. FT STRAND 118 127 {ECO:0000244|PDB:5M02}. FT STRAND 129 131 {ECO:0000244|PDB:5SWZ}. FT STRAND 133 142 {ECO:0000244|PDB:5M02}. FT STRAND 145 150 {ECO:0000244|PDB:5M02}. FT STRAND 157 159 {ECO:0000244|PDB:5M02}. FT HELIX 162 174 {ECO:0000244|PDB:5M02}. FT HELIX 176 185 {ECO:0000244|PDB:5M02}. FT HELIX 187 203 {ECO:0000244|PDB:5M02}. FT STRAND 210 218 {ECO:0000244|PDB:5M02}. FT TURN 219 221 {ECO:0000244|PDB:5M01}. FT STRAND 222 235 {ECO:0000244|PDB:5M02}. FT STRAND 238 243 {ECO:0000244|PDB:5M02}. FT STRAND 246 248 {ECO:0000244|PDB:3CC5}. FT HELIX 249 251 {ECO:0000244|PDB:1YN6}. FT STRAND 252 254 {ECO:0000244|PDB:5M02}. FT STRAND 261 263 {ECO:0000244|PDB:5M02}. FT STRAND 265 274 {ECO:0000244|PDB:5M02}. FT HELIX 278 280 {ECO:0000244|PDB:5M02}. FT STRAND 281 286 {ECO:0000244|PDB:5M02}. FT STRAND 290 292 {ECO:0000244|PDB:5M02}. FT STRAND 294 296 {ECO:0000244|PDB:5M02}. SQ SEQUENCE 362 AA; 40836 MW; 6EE6AEF97263FA71 CRC64; MGAMAPRTLL LLLAAALAPT QTRAGPHSMR YFETAVSRPG LEEPRYISVG YVDNKEFVRF DSDAENPRYE PRAPWMEQEG PEYWERETQK AKGQEQWFRV SLRNLLGYYN QSAGGSHTLQ QMSGCDLGSD WRLLRGYLQF AYEGRDYIAL NEDLKTWTAA DMAAQITRRK WEQSGAAEHY KAYLEGECVE WLHRYLKNGN ATLLRTDSPK AHVTHHPRSK GEVTLRCWAL GFYPADITLT WQLNGEELTQ DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCRVYHEGL PEPLTLRWEP PPSTDSYMVI VAVLGVLGAM AIIGAVVAFV MKRRRNTGGK GGDYALAPGS QSSEMSLRDC KA // ID HA11_RAT Reviewed; 319 AA. AC P15978; DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1990, sequence version 1. DT 23-MAY-2018, entry version 118. DE RecName: Full=Class I histocompatibility antigen, Non-RT1.A alpha-1 chain; DE Flags: Precursor; GN Name=RT1-Aw2; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2315309; DOI=10.1073/pnas.87.6.2167; RA Rada C., Lorenzi R., Powis S.J., van den Bogaerde J., Parham P., RA Howard J.C.; RT "Concerted evolution of class I genes in the major histocompatibility RT complex of murine rodents."; RL Proc. Natl. Acad. Sci. U.S.A. 87:2167-2171(1990). RN [2] RP PROTEIN SEQUENCE OF 25-49. RX PubMed=3585249; DOI=10.1084/jem.165.6.1595; RA Spencer S.C., Fabre J.W.; RT "Identification in rat liver and serum of water-soluble class I MHC RT molecules possibly homologous to the murine Q10 gene product."; RL J. Exp. Med. 165:1595-1608(1987). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M31038; AAA41608.1; -; mRNA. DR PIR; B35090; B35090. DR RefSeq; NP_036777.1; NM_012645.1. DR UniGene; Rn.116785; -. DR UniGene; Rn.116787; -. DR UniGene; Rn.128939; -. DR UniGene; Rn.145377; -. DR UniGene; Rn.217243; -. DR UniGene; Rn.219012; -. DR UniGene; Rn.222446; -. DR UniGene; Rn.228833; -. DR UniGene; Rn.233151; -. DR UniGene; Rn.40130; -. DR ProteinModelPortal; P15978; -. DR SMR; P15978; -. DR PRIDE; P15978; -. DR GeneID; 24737; -. DR KEGG; rno:24737; -. DR CTD; 24737; -. DR RGD; 3512; RT1-Aw2. DR HOVERGEN; HBG016709; -. DR InParanoid; P15978; -. DR KO; K06751; -. DR PhylomeDB; P15978; -. DR PRO; PR:P15978; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Glycoprotein; Immunity; Membrane; MHC I; Reference proteome; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1 24 {ECO:0000255}. FT CHAIN 25 319 Class I histocompatibility antigen, Non- FT RT1.A alpha-1 chain. FT /FTId=PRO_0000018943. FT TOPO_DOM 25 307 Extracellular. {ECO:0000255}. FT TRANSMEM 308 319 Helical. {ECO:0000255}. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 307 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT CARBOHYD 280 280 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 319 AA; 36570 MW; E87C15B2409E1FC0 CRC64; MGAMAPRTLL LLLAAVLAPT QTWAGSHSLR YFHTAVSRPG LGEPRFISVG YVDDTQFVRY DSDAENPRYE PRARWMEREG PEYWEEQTLV AKGQELDYRV SLRNLLSYYN QSEGGSHTIQ RMYGCDVGSD GSLLRGYEQH AYDGRDYIAL NEDLKTWAVA DFAAWITRSK WQRNGAAERS RAYLEGTCVE WLLRYLERGK ETLLRSDPPE AHVTLHPRPE GDVTLRCWAL GFYPADITLT WQLNGEDLTQ DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCRVEHEGL PEPLSQRWEP SPSTDSNLLL LFLELWQFL // ID HA12_MOUSE Reviewed; 365 AA. AC P01900; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 13-AUG-1987, sequence version 1. DT 12-SEP-2018, entry version 163. DE RecName: Full=H-2 class I histocompatibility antigen, D-D alpha chain; DE Short=H-2D(D); DE Flags: Precursor; GN Name=H2-D1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6571712; RA Margulies D.H., Evans G.A., Ozato K., Camerini-Otero R.D., Tanaka K., RA Appella E., Seidman J.G.; RT "Expression of H-2Dd and H-2Ld mouse major histocompatibility antigen RT genes in L cells after DNA-mediated gene transfer."; RL J. Immunol. 130:463-470(1983). RN [2] RP SEQUENCE REVISION. RX PubMed=3925012; RA Margulies D.H., Evans G.A., Ozato K., Camerini-Otero R.D., Tanaka K., RA Appella E., Seidman J.G.; RT "Partial nucleotide sequence of H-2Dd major histocompatibility antigen RT gene."; RL J. Immunol. 135:1537-1537(1985). RN [3] RP NUCLEOTIDE SEQUENCE. RX PubMed=3856254; DOI=10.1073/pnas.82.4.1175; RA Sher B.T., Nairn R., Coligan J.E., Hood L.E.; RT "DNA sequence of the mouse H-2Dd transplantation antigen gene."; RL Proc. Natl. Acad. Sci. U.S.A. 82:1175-1179(1985). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=BALB/cJ; RX PubMed=9869916; RA Wang M., Stepkowski S.M., Hebert J.S., Tian L., Yu J., Kahan B.D.; RT "Nucleotide sequences of three H-2K and three H-2D complementary DNA RT clones coding mouse class I MHC heavy chain proteins."; RL Ann. Transplant. 1:26-31(1996). RN [5] RP PROTEIN SEQUENCE OF 25-125. RX PubMed=7295646; DOI=10.1021/bi00519a033; RA Nairn R., Nathenson S.G., Coligan J.E.; RT "Amino acid sequence of cyanogen bromide fragment CN-C (residues 24- RT 98) of the mouse histocompatibility antigen H-2Dd. A comparison of the RT amino-terminal 100 residues of H-2Dd, Dd, Kd, and Kb reveals discrete RT areas of diversity."; RL Biochemistry 20:4739-4745(1981). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356 AND SER-359, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006; RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M., RA Thibault P.; RT "The phagosomal proteome in interferon-gamma-activated macrophages."; RL Immunity 30:143-154(2009). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brown adipose tissue, Kidney, Liver, Lung, and Spleen; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [8] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS). RX PubMed=9729040; DOI=10.1016/S1074-7613(00)80602-0; RA Achour A., Persson K., Harris R.A., Sundbaeck J., Sentman C.L., RA Lindqvist Y., Schneider G., Kaerre K.; RT "The crystal structure of H-2Dd MHC class I complexed with the HIV-1- RT derived peptide P18-I10 at 2.4-A resolution: implications for T cell RT and NK cell recognition."; RL Immunity 9:199-208(1998). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; L29190; AAA39581.1; -; Genomic_DNA. DR EMBL; U47326; AAB17604.1; -; mRNA. DR UniGene; Mm.439675; -. DR PDB; 1BII; X-ray; 2.40 A; A=1-365. DR PDB; 1DDH; X-ray; 3.10 A; A=26-298. DR PDB; 1QO3; X-ray; 2.30 A; A=26-301. DR PDB; 3DMM; X-ray; 2.60 A; A=26-299. DR PDB; 3E6F; X-ray; 2.41 A; A=26-298. DR PDB; 3E6H; X-ray; 2.10 A; A=26-299. DR PDB; 3ECB; X-ray; 1.70 A; A=26-301. DR PDB; 5IVX; X-ray; 2.10 A; A=26-301. DR PDB; 5KD4; X-ray; 3.05 A; A/C=26-301. DR PDB; 5KD7; X-ray; 2.35 A; A/C/F/I=26-300. DR PDB; 5T7G; X-ray; 1.96 A; A/C=26-300. DR PDB; 5WER; X-ray; 3.41 A; A/D/G/J=26-301. DR PDB; 5WES; X-ray; 2.71 A; A=26-301. DR PDB; 5WET; X-ray; 2.64 A; A=26-301. DR PDB; 5WEU; X-ray; 1.58 A; A=26-301. DR PDBsum; 1BII; -. DR PDBsum; 1DDH; -. DR PDBsum; 1QO3; -. DR PDBsum; 3DMM; -. DR PDBsum; 3E6F; -. DR PDBsum; 3E6H; -. DR PDBsum; 3ECB; -. DR PDBsum; 5IVX; -. DR PDBsum; 5KD4; -. DR PDBsum; 5KD7; -. DR PDBsum; 5T7G; -. DR PDBsum; 5WER; -. DR PDBsum; 5WES; -. DR PDBsum; 5WET; -. DR PDBsum; 5WEU; -. DR ProteinModelPortal; P01900; -. DR SMR; P01900; -. DR DIP; DIP-6110N; -. DR MINT; P01900; -. DR iPTMnet; P01900; -. DR PhosphoSitePlus; P01900; -. DR EPD; P01900; -. DR MaxQB; P01900; -. DR PeptideAtlas; P01900; -. DR PRIDE; P01900; -. DR MGI; MGI:95896; H2-D1. DR HOVERGEN; HBG016709; -. DR ChiTaRS; H2-D1; mouse. DR EvolutionaryTrace; P01900; -. DR Proteomes; UP000000589; Unplaced. DR CleanEx; MM_H2-D1; -. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IDA:MGI. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; ISO:MGI. DR GO; GO:0042277; F:peptide binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0046977; F:TAP binding; ISO:MGI. DR GO; GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IDA:MGI. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0010977; P:negative regulation of neuron projection development; IDA:MGI. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Direct protein sequencing; KW Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I; KW Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000269|PubMed:7295646}. FT CHAIN 25 365 H-2 class I histocompatibility antigen, FT D-D alpha chain. FT /FTId=PRO_0000018924. FT TOPO_DOM 25 311 Extracellular. {ECO:0000255}. FT TRANSMEM 312 334 Helical. {ECO:0000255}. FT TOPO_DOM 335 365 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 311 Connecting peptide. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000244|PubMed:19144319}. FT MOD_RES 359 359 Phosphoserine. FT {ECO:0000244|PubMed:19144319}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 200 200 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT STRAND 27 36 {ECO:0000244|PDB:5WEU}. FT STRAND 41 43 {ECO:0000244|PDB:5WEU}. FT STRAND 45 52 {ECO:0000244|PDB:5WEU}. FT STRAND 55 61 {ECO:0000244|PDB:5WEU}. FT STRAND 64 66 {ECO:0000244|PDB:5WEU}. FT STRAND 70 73 {ECO:0000244|PDB:3E6H}. FT HELIX 74 76 {ECO:0000244|PDB:5WEU}. FT HELIX 81 109 {ECO:0000244|PDB:5WEU}. FT STRAND 113 115 {ECO:0000244|PDB:5IVX}. FT STRAND 118 127 {ECO:0000244|PDB:5WEU}. FT STRAND 129 131 {ECO:0000244|PDB:3E6H}. FT STRAND 133 142 {ECO:0000244|PDB:5WEU}. FT STRAND 145 150 {ECO:0000244|PDB:5WEU}. FT STRAND 157 159 {ECO:0000244|PDB:5WEU}. FT HELIX 162 174 {ECO:0000244|PDB:5WEU}. FT HELIX 176 185 {ECO:0000244|PDB:5WEU}. FT HELIX 187 198 {ECO:0000244|PDB:5WEU}. FT TURN 199 204 {ECO:0000244|PDB:5WEU}. FT STRAND 210 217 {ECO:0000244|PDB:5WEU}. FT STRAND 221 235 {ECO:0000244|PDB:5WEU}. FT STRAND 238 246 {ECO:0000244|PDB:5WEU}. FT TURN 249 251 {ECO:0000244|PDB:3ECB}. FT STRAND 252 254 {ECO:0000244|PDB:5WEU}. FT STRAND 261 263 {ECO:0000244|PDB:5WEU}. FT STRAND 265 273 {ECO:0000244|PDB:5WEU}. FT HELIX 278 280 {ECO:0000244|PDB:5WEU}. FT STRAND 282 286 {ECO:0000244|PDB:5WEU}. FT STRAND 290 292 {ECO:0000244|PDB:3E6H}. FT STRAND 294 296 {ECO:0000244|PDB:5WEU}. SQ SEQUENCE 365 AA; 41110 MW; D127F5A4F0E79513 CRC64; MGAMAPRTLL LLLAAALGPT QTRAGSHSLR YFVTAVSRPG FGEPRYMEVG YVDNTEFVRF DSDAENPRYE PRARWIEQEG PEYWERETRR AKGNEQSFRV DLRTALRYYN QSAGGSHTLQ WMAGCDVESD GRLLRGYWQF AYDGCDYIAL NEDLKTWTAA DMAAQITRRK WEQAGAAERD RAYLEGECVE WLRRYLKNGN ATLLRTDPPK AHVTHHRRPE GDVTLRCWAL GFYPADITLT WQLNGEELTQ EMELVETRPA GDGTFQKWAS VVVPLGKEQK YTCHVEHEGL PEPLTLRWGK EEPPSSTKTN TVIIAVPVVL GAVVILGAVM AFVMKRRRNT GGKGGDYALA PGSQSSDMSL PDCKV // ID HA12_RAT Reviewed; 371 AA. AC P16391; O02940; DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1998, sequence version 2. DT 12-SEP-2018, entry version 135. DE RecName: Full=RT1 class I histocompatibility antigen, AA alpha chain; DE Flags: Precursor; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2315309; DOI=10.1073/pnas.87.6.2167; RA Rada C., Lorenzi R., Powis S.J., van den Bogaerde J., Parham P., RA Howard J.C.; RT "Concerted evolution of class I genes in the major histocompatibility RT complex of murine rodents."; RL Proc. Natl. Acad. Sci. U.S.A. 87:2167-2171(1990). RN [2] RP SEQUENCE REVISION. RC STRAIN=DA; TISSUE=Lymph node, and Spleen; RA Howard J.C.; RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases. RN [3] RP X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 25-299. RX PubMed=11163232; DOI=10.1016/S1074-7613(01)00091-7; RA Speir J.A., Stevens J., Joly E., Butcher G.W., Wilson I.A.; RT "Two different, highly exposed, bulged structures for an unusually RT long peptide bound to rat MHC class I RT1-A(a)."; RL Immunity 14:81-92(2001). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M31018; AAB49324.1; -; mRNA. DR PIR; A35090; A35090. DR UniGene; Rn.116785; -. DR UniGene; Rn.116787; -. DR UniGene; Rn.128939; -. DR UniGene; Rn.145377; -. DR UniGene; Rn.217243; -. DR UniGene; Rn.219012; -. DR UniGene; Rn.222446; -. DR UniGene; Rn.228833; -. DR UniGene; Rn.233151; -. DR UniGene; Rn.40130; -. DR PDB; 1ED3; X-ray; 2.55 A; A/D=25-299. DR PDB; 1KJM; X-ray; 2.35 A; A=25-300. DR PDBsum; 1ED3; -. DR PDBsum; 1KJM; -. DR ProteinModelPortal; P16391; -. DR SMR; P16391; -. DR MINT; P16391; -. DR PRIDE; P16391; -. DR HOVERGEN; HBG016709; -. DR EvolutionaryTrace; P16391; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000255}. FT CHAIN 25 371 RT1 class I histocompatibility antigen, FT AA alpha chain. FT /FTId=PRO_0000018944. FT TOPO_DOM 25 311 Extracellular. {ECO:0000255}. FT TRANSMEM 312 336 Helical. {ECO:0000255}. FT TOPO_DOM 337 371 Cytoplasmic. FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 311 Connecting peptide. FT MOD_RES 362 362 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 365 365 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 280 280 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT STRAND 26 36 {ECO:0000244|PDB:1KJM}. FT STRAND 41 43 {ECO:0000244|PDB:1KJM}. FT STRAND 45 52 {ECO:0000244|PDB:1KJM}. FT STRAND 55 61 {ECO:0000244|PDB:1KJM}. FT STRAND 64 66 {ECO:0000244|PDB:1KJM}. FT HELIX 74 76 {ECO:0000244|PDB:1KJM}. FT STRAND 77 79 {ECO:0000244|PDB:1ED3}. FT HELIX 81 108 {ECO:0000244|PDB:1KJM}. FT STRAND 113 115 {ECO:0000244|PDB:1ED3}. FT STRAND 118 128 {ECO:0000244|PDB:1KJM}. FT STRAND 133 142 {ECO:0000244|PDB:1KJM}. FT STRAND 145 150 {ECO:0000244|PDB:1KJM}. FT STRAND 157 162 {ECO:0000244|PDB:1KJM}. FT HELIX 163 173 {ECO:0000244|PDB:1KJM}. FT HELIX 176 185 {ECO:0000244|PDB:1KJM}. FT HELIX 187 198 {ECO:0000244|PDB:1KJM}. FT HELIX 200 203 {ECO:0000244|PDB:1KJM}. FT STRAND 210 217 {ECO:0000244|PDB:1KJM}. FT STRAND 221 235 {ECO:0000244|PDB:1KJM}. FT STRAND 238 243 {ECO:0000244|PDB:1KJM}. FT TURN 248 251 {ECO:0000244|PDB:1ED3}. FT STRAND 261 263 {ECO:0000244|PDB:1KJM}. FT STRAND 265 273 {ECO:0000244|PDB:1KJM}. FT HELIX 278 280 {ECO:0000244|PDB:1KJM}. FT STRAND 281 285 {ECO:0000244|PDB:1KJM}. FT STRAND 294 296 {ECO:0000244|PDB:1KJM}. SQ SEQUENCE 371 AA; 41830 MW; 79C162463E1746D8 CRC64; MEAMAPRTLL LLLAAALAPT QTRAGSHSLR YFYTAVSRPG LGEPRFIAVG YVDDTEFVRF DSDAENPRME PRARWMEREG PEYWEQQTRI AKEWEQIYRV DLRTLRGYYN QSEGGSHTIQ EMYGCDVGSD GSLLRGYRQD AYDGRDYIAL NEDLKTWTAA DFAAQITRNK WERARYAERL RAYLEGTCVE WLSRYLELGK ETLLRSDPPE AHVTLHPRPE GDVTLRCWAL GFYPADITLT WQLNGEDLTQ DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCRVEHEGL PKPLSQRWEP SPSTDSNMET TVIYVILGAV AMIGAVAIIG AMVAVVRRRK RNTGGKGGDY APAPGRDSSQ SSDVSLPDCK A // ID HA13_MOUSE Reviewed; 362 AA. AC P14426; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 20-JUN-2018, entry version 135. DE RecName: Full=H-2 class I histocompatibility antigen, D-K alpha chain; DE Short=H-2D(K); DE Flags: Precursor; GN Name=H2-D1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=C3H/HeJ; RX PubMed=3680952; RA Watts S., Vogel J.M., Harriman W.D., Itoh T., Stauss H.J., RA Goodenow R.S.; RT "DNA sequence analysis of the C3H H-2Kk and H-2Dk loci. Evolutionary RT relationships to H-2 genes from four other mouse strains."; RL J. Immunol. 139:3878-3885(1987). RN [2] RP UBIQUITINATION. RX PubMed=11672544; DOI=10.1016/S1074-7613(01)00213-8; RA Boname J.M., Stevenson P.G.; RT "MHC class I ubiquitination by a viral PHD/LAP finger protein."; RL Immunity 15:627-636(2001). RN [3] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110 AND ASN-200. RC TISSUE=Myoblast; RX PubMed=19656770; DOI=10.1074/mcp.M900195-MCP200; RA Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., RA Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., RA Wollscheid B.; RT "The mouse C2C12 myoblast cell surface N-linked glycoproteome: RT identification, glycosite occupancy, and membrane orientation."; RL Mol. Cell. Proteomics 8:2555-2569(2009). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in case of infection by murid herpesvirus CC 4, by the viral E3 ligase K3 (mK3), leading to target the protein CC for rapid degradation by the endoplasmic reticulum-associated CC degradation (ERAD) system. Ubiquitination takes place on lysine, CC as well as serine and threonine residues present in the CC cytoplasmic tail. Hydroxylated serine and threonine residues in CC the cytoplasmic tail are subject to ubiquitination via ester bonds CC instead of the classical isopeptide linkage (Probable). CC {ECO:0000305|PubMed:11672544}. CC -!- PTM: Hydroxylation of residues in the cytoplasmic tail. CC {ECO:0000250}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M18524; AAA53201.1; -; Genomic_DNA. DR PIR; I71998; I71998. DR UniGene; Mm.439675; -. DR ProteinModelPortal; P14426; -. DR SMR; P14426; -. DR iPTMnet; P14426; -. DR PhosphoSitePlus; P14426; -. DR SwissPalm; P14426; -. DR EPD; P14426; -. DR MaxQB; P14426; -. DR PeptideAtlas; P14426; -. DR PRIDE; P14426; -. DR MGI; MGI:95896; H2-D1. DR HOVERGEN; HBG016709; -. DR ChiTaRS; H2-D1; mouse. DR Proteomes; UP000000589; Unplaced. DR CleanEx; MM_H2-D1; -. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IDA:MGI. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; ISO:MGI. DR GO; GO:0042277; F:peptide binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0046977; F:TAP binding; ISO:MGI. DR GO; GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IDA:MGI. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0010977; P:negative regulation of neuron projection development; IDA:MGI. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Hydroxylation; KW Immunity; Membrane; MHC I; Phosphoprotein; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Ubl conjugation. FT SIGNAL 1 24 {ECO:0000250}. FT CHAIN 25 362 H-2 class I histocompatibility antigen, FT D-K alpha chain. FT /FTId=PRO_0000018925. FT TOPO_DOM 25 306 Extracellular. {ECO:0000255}. FT TRANSMEM 307 333 Helical. {ECO:0000255}. FT TOPO_DOM 334 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 306 Connecting peptide. FT MOD_RES 353 353 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:19656770}. FT CARBOHYD 200 200 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:19656770}. FT CARBOHYD 280 280 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 362 AA; 40620 MW; FF071720457D084D CRC64; MGAMVPRTLL LLLAAALAPA QTRAGPHSLR YFETVVSRPG LGEPRFISVG YVDNTEFVRF DSDAENPRDE PRVRWMEQEG PEYWERETQI AKGNEQSFRV DLRTLLRYYN QSEGGSHTIQ RLSGCDVGSD WRLLRGYEQF AYDGCDYIAL NEDLKTWTAA DMAALITKHK WEQAGAAERD RAYLEGTCVE WLRRYLELGN ATLLHTDSPK AHVTHHPRSK VEVTLRCWAL GFYPADITLT WQLNGEELTQ DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCHVYHEGL PEPLTLRWEP PPSTDSYMVI VAVLGVLGAV AIIGAVVAFV MMMRRNTGGK GGDYTLTPGS QSSEMSLPDC KA // ID HA14_MOUSE Reviewed; 368 AA. AC P14427; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 20-JUN-2018, entry version 130. DE RecName: Full=H-2 class I histocompatibility antigen, D-P alpha chain; DE Short=H-2D(P); DE Flags: Precursor; GN Name=H2-D1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=3082989; RA Schepart B.S., Takahashi H., Cozad K.M., Murray R., Ozato K., RA Appella E., Frelinger J.A.; RT "The nucleotide sequence and comparative analysis of the H-2Dp class I RT H-2 gene."; RL J. Immunol. 136:3489-3495(1986). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-111. RX PubMed=2903482; DOI=10.1093/nar/16.20.9761; RA Murray R., Pederson K., Prosser H., Muller D., Hutchison C.A. III, RA Frelinger J.A.; RT "Random oligonucleotide mutagenesis: application to a large protein RT coding sequence of a major histocompatibility complex class I gene, H- RT 2DP."; RL Nucleic Acids Res. 16:9761-9773(1988). RN [3] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brown adipose tissue, Kidney, Liver, Lung, and Spleen; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M12381; AAA39603.1; -; Genomic_DNA. DR PIR; I55961; I55961. DR UniGene; Mm.439675; -. DR ProteinModelPortal; P14427; -. DR SMR; P14427; -. DR EPD; P14427; -. DR MaxQB; P14427; -. DR PeptideAtlas; P14427; -. DR PRIDE; P14427; -. DR MGI; MGI:95896; H2-D1. DR HOVERGEN; HBG016709; -. DR InParanoid; P14427; -. DR ChiTaRS; H2-D1; mouse. DR Proteomes; UP000000589; Unplaced. DR CleanEx; MM_H2-D1; -. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IDA:MGI. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; ISO:MGI. DR GO; GO:0042277; F:peptide binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0046977; F:TAP binding; ISO:MGI. DR GO; GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IDA:MGI. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0010977; P:negative regulation of neuron projection development; IDA:MGI. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 21 {ECO:0000250}. FT CHAIN 22 368 H-2 class I histocompatibility antigen, FT D-P alpha chain. FT /FTId=PRO_0000018926. FT TOPO_DOM 22 303 Extracellular. {ECO:0000255}. FT TRANSMEM 304 330 Helical. {ECO:0000255}. FT TOPO_DOM 331 368 Cytoplasmic. {ECO:0000255}. FT DOMAIN 206 294 Ig-like C1-type. FT REGION 22 111 Alpha-1. FT REGION 112 203 Alpha-2. FT REGION 204 295 Alpha-3. FT REGION 296 303 Connecting peptide. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 353 353 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT CARBOHYD 107 107 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 197 197 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 277 277 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 122 185 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 224 280 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 368 AA; 41342 MW; EFD4FB8E14E6FAC0 CRC64; MAPRTLLLLL AAALAPTQTR AGPHSLRYFV TAVSRPGLGK PRYMEVGYVD NTEFVRFDSD AENPRMKPRV RWMEQEGPEY WEQETQNAKD HEQSFRVSLR NLLGYYNQSK GGSHTIQGMR GCDVGSDWRL LRGYEQFAYD GPDYIALNED LKTWTAADMA AQITRRKWEQ AGAAETLRAY LEGACVEWLR RYLELGNATL LCTDPPKAHV THHPRSEGKV TLRCWALGFY PADITLTWQL NGEELTQDME LVETRPAGDG TFQKWAALVV PLGKEQNYTC HVEHEGLPEP LTLRWEPPPS TDSYMVIVAV LVVLGAVFII GAVVAFVMMM RRNTGGKGGD YTLAPGSQSS EMSLRDCKVM VHDSHSLA // ID HA15_MOUSE Reviewed; 357 AA. AC P06339; DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1988, sequence version 1. DT 12-SEP-2018, entry version 160. DE RecName: Full=H-2 class I histocompatibility antigen, D-37 alpha chain; DE Flags: Precursor; GN Name=H2-T23; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=DBA/2J; RX PubMed=3838699; DOI=10.1016/S0092-8674(85)80020-9; RA Lalanne J.-L., Transy C., Guerin S., Darche S., Meulien P., RA Kourilsky P.; RT "Expression of class I genes in the major histocompatibility complex: RT identification of eight distinct mRNAs in DBA/2 mouse liver."; RL Cell 41:469-478(1985). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=BALB/cJ; TISSUE=Sperm; RX PubMed=3036997; DOI=10.1084/jem.166.2.341; RA Transy C., Nash S.R., David-Watine B., Cochet M., Hunt S.W. III, RA Hood L.E., Kourilsky P.; RT "A low polymorphic mouse H-2 class I gene from the Tla complex is RT expressed in a broad variety of cell types."; RL J. Exp. Med. 166:341-361(1987). RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-347, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006; RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M., RA Thibault P.; RT "The phagosomal proteome in interferon-gamma-activated macrophages."; RL Immunity 30:143-154(2009). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M11284; AAA39693.1; -; mRNA. DR EMBL; Y00629; CAA68665.1; -; Genomic_DNA. DR CCDS; CCDS28715.1; -. DR PIR; A02205; HLMS37. DR RefSeq; NP_034528.1; NM_010398.3. DR UniGene; Mm.439648; -. DR UniGene; Mm.441651; -. DR PDB; 3VJ6; X-ray; 1.90 A; A=21-297. DR PDBsum; 3VJ6; -. DR ProteinModelPortal; P06339; -. DR SMR; P06339; -. DR STRING; 10090.ENSMUSP00000099739; -. DR iPTMnet; P06339; -. DR PhosphoSitePlus; P06339; -. DR EPD; P06339; -. DR PaxDb; P06339; -. DR PRIDE; P06339; -. DR Ensembl; ENSMUST00000102678; ENSMUSP00000099739; ENSMUSG00000067212. DR GeneID; 15040; -. DR KEGG; mmu:15040; -. DR UCSC; uc008cjr.1; mouse. DR CTD; 15040; -. DR MGI; MGI:95957; H2-T23. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; P06339; -. DR KO; K06751; -. DR OMA; GYCQEAY; -. DR OrthoDB; EOG091G09OH; -. DR PhylomeDB; P06339; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR PRO; PR:P06339; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000067212; Expressed in 235 organ(s), highest expression level in lymph node. DR CleanEx; MM_H2-T23; -. DR ExpressionAtlas; P06339; baseline and differential. DR Genevisible; P06339; MM. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0032398; C:MHC class Ib protein complex; ISO:MGI. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042288; F:MHC class I protein binding; ISO:MGI. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0002250; P:adaptive immune response; ISO:MGI. DR GO; GO:0019731; P:antibacterial humoral response; ISO:MGI. DR GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; ISO:MGI. DR GO; GO:0002489; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; IDA:MGI. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0036037; P:CD8-positive, alpha-beta T cell activation; ISO:MGI. DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:MGI. DR GO; GO:0048839; P:inner ear development; IDA:MGI. DR GO; GO:2000566; P:positive regulation of CD8-positive, alpha-beta T cell proliferation; ISO:MGI. DR GO; GO:0051024; P:positive regulation of immunoglobulin secretion; ISO:MGI. DR GO; GO:0032736; P:positive regulation of interleukin-13 production; ISO:MGI. DR GO; GO:0032753; P:positive regulation of interleukin-4 production; ISO:MGI. DR GO; GO:0002717; P:positive regulation of natural killer cell mediated immunity; ISO:MGI. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI. DR GO; GO:0032759; P:positive regulation of TRAIL production; ISO:MGI. DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISO:MGI. DR GO; GO:0042270; P:protection from natural killer cell mediated cytotoxicity; ISO:MGI. DR GO; GO:0002715; P:regulation of natural killer cell mediated immunity; ISO:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Phosphoprotein; Reference proteome; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1 20 {ECO:0000255}. FT CHAIN 21 357 H-2 class I histocompatibility antigen, FT D-37 alpha chain. FT /FTId=PRO_0000018927. FT TOPO_DOM 21 304 Extracellular. {ECO:0000255}. FT TRANSMEM 305 327 Helical. {ECO:0000255}. FT TOPO_DOM 328 357 Cytoplasmic. {ECO:0000255}. FT DOMAIN 205 293 Ig-like C1-type. FT REGION 21 110 Alpha-1. FT REGION 111 202 Alpha-2. FT REGION 203 294 Alpha-3. FT REGION 295 304 Connecting peptide. FT MOD_RES 347 347 Phosphoserine. FT {ECO:0000244|PubMed:19144319}. FT CARBOHYD 106 106 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 196 196 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 121 184 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 223 279 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT STRAND 23 32 {ECO:0000244|PDB:3VJ6}. FT STRAND 41 48 {ECO:0000244|PDB:3VJ6}. FT STRAND 51 57 {ECO:0000244|PDB:3VJ6}. FT STRAND 60 62 {ECO:0000244|PDB:3VJ6}. FT STRAND 66 69 {ECO:0000244|PDB:3VJ6}. FT HELIX 70 74 {ECO:0000244|PDB:3VJ6}. FT HELIX 77 105 {ECO:0000244|PDB:3VJ6}. FT STRAND 114 123 {ECO:0000244|PDB:3VJ6}. FT STRAND 129 138 {ECO:0000244|PDB:3VJ6}. FT STRAND 141 146 {ECO:0000244|PDB:3VJ6}. FT STRAND 153 155 {ECO:0000244|PDB:3VJ6}. FT HELIX 158 169 {ECO:0000244|PDB:3VJ6}. FT HELIX 172 181 {ECO:0000244|PDB:3VJ6}. FT HELIX 183 194 {ECO:0000244|PDB:3VJ6}. FT HELIX 196 199 {ECO:0000244|PDB:3VJ6}. FT STRAND 206 215 {ECO:0000244|PDB:3VJ6}. FT STRAND 218 231 {ECO:0000244|PDB:3VJ6}. FT STRAND 234 239 {ECO:0000244|PDB:3VJ6}. FT STRAND 257 259 {ECO:0000244|PDB:3VJ6}. FT STRAND 261 270 {ECO:0000244|PDB:3VJ6}. FT HELIX 274 276 {ECO:0000244|PDB:3VJ6}. FT STRAND 277 282 {ECO:0000244|PDB:3VJ6}. FT STRAND 290 292 {ECO:0000244|PDB:3VJ6}. SQ SEQUENCE 357 AA; 40875 MW; 62139862B099D411 CRC64; MLLFAHLLQL LVSATVPTQS SPHSLRYFTT AVSRPGLGEP RFIIVGYVDD TQFVRFDSDA ENPRMEPRAR WIEQEGPEYW ERETWKARDM GRNFRVNLRT LLGYYNQSND ESHTLQWMYG CDVGPDGRLL RGYCQEAYDG QDYISLNEDL RSWTANDIAS QISKHKSEAV DEAHQQRAYL QGPCVEWLHR YLRLGNETLQ RSDPPKAHVT HHPRSEDEVT LRCWALGFYP ADITLTWQLN GEELTQDMEL VETRPAGDGT FQKWAAVVVP LGKEQYYTCH VYHEGLPEPL TLRWEPPPST VSNMVIIAVL VVLGAVIILG AVVAFVMKRR RHIGVKGCYA HVLGSKSFQT SDWPQKA // ID HA17_MOUSE Reviewed; 334 AA. AC P14429; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 12-SEP-2018, entry version 173. DE RecName: Full=H-2 class I histocompatibility antigen, Q7 alpha chain; DE AltName: Full=QA-2 antigen; DE Flags: Precursor; GN Name=H2-Q7; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=C57BL/10; RX PubMed=3004940; RA Devlin J.J., Weiss E.H., Paulson M., Flavell R.A.; RT "Duplicated gene pairs and alleles of class I genes in the Qa2 region RT of the murine major histocompatibility complex: a comparison."; RL EMBO J. 4:3203-3207(1985). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=C57BL/10; RX PubMed=3502706; DOI=10.1084/jem.165.5.1358; RA Waneck G.L., Sherman D.H., Calvin S., Allen H., Flavell R.A.; RT "Tissue-specific expression of cell-surface Qa-2 antigen from a RT transfected Q7b gene of C57BL/10 mice."; RL J. Exp. Med. 165:1358-1370(1987). RN [3] RP NUCLEOTIDE SEQUENCE. RX PubMed=6895187; DOI=10.1016/0092-8674(81)90175-6; RA Steinmetz M., Moore K.W., Frelinger J.G., Sher B.T., Shen F.W., RA Boyse E.A., Hood L.; RT "A pseudogene homologous to mouse transplantation antigens: RT transplantation antigens are encoded by eight exons that correlate RT with protein domains."; RL Cell 25:683-692(1981). RN [4] RP NUCLEOTIDE SEQUENCE OF 292-334. RX PubMed=2249652; RA Ulker N., Lewis K.D., Hood L.E., Stroynowski I.; RT "Activated T cells transcribe an alternatively spliced mRNA encoding a RT soluble form of Qa-2 antigen."; RL EMBO J. 9:3839-3847(1990). RN [5] RP NUCLEOTIDE SEQUENCE OF 300-334. RX PubMed=2584927; DOI=10.1084/jem.170.6.1837; RA Brorson K.A., Hunt S.W. III, Hunkapiller T., Sun Y.H., Cheroutre H., RA Nickerson D.A., Hood L.; RT "Comparison of exon 5 sequences from 35 class I genes of the BALB/c RT mouse."; RL J. Exp. Med. 170:1837-1858(1989). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=CAA28977.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X03210; CAA26954.1; -; Genomic_DNA. DR EMBL; X03441; CAA26954.1; JOINED; Genomic_DNA. DR EMBL; X05389; CAA28977.1; ALT_INIT; mRNA. DR EMBL; X57330; CAA40606.1; -; mRNA. DR CCDS; CCDS28697.1; -. DR PIR; A24582; A24582. DR RefSeq; NP_034524.3; NM_010394.4. DR UniGene; Mm.431282; -. DR PDB; 1K8D; X-ray; 2.30 A; A=22-295. DR PDBsum; 1K8D; -. DR ProteinModelPortal; P14429; -. DR SMR; P14429; -. DR MINT; P14429; -. DR STRING; 10090.ENSMUSP00000071843; -. DR iPTMnet; P14429; -. DR PhosphoSitePlus; P14429; -. DR EPD; P14429; -. DR MaxQB; P14429; -. DR PaxDb; P14429; -. DR PRIDE; P14429; -. DR Ensembl; ENSMUST00000071951; ENSMUSP00000071843; ENSMUSG00000060550. DR GeneID; 15018; -. DR KEGG; mmu:15018; -. DR CTD; 15018; -. DR MGI; MGI:95936; H2-Q7. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; P14429; -. DR KO; K06751; -. DR OMA; FQRMIGC; -. DR OrthoDB; EOG091G09OH; -. DR PhylomeDB; P14429; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR EvolutionaryTrace; P14429; -. DR PRO; PR:P14429; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000060550; Expressed in 24 organ(s), highest expression level in spleen. DR CleanEx; MM_H2-Q7; -. DR ExpressionAtlas; P14429; baseline and differential. DR Genevisible; P14429; MM. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; ISO:MGI. DR GO; GO:0042277; F:peptide binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0046977; F:TAP binding; ISO:MGI. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0071346; P:cellular response to interferon-gamma; IDA:MGI. DR GO; GO:0007566; P:embryo implantation; IDA:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 21 {ECO:0000250}. FT CHAIN 22 334 H-2 class I histocompatibility antigen, FT Q7 alpha chain. FT /FTId=PRO_0000018933. FT TOPO_DOM 22 310 Extracellular. {ECO:0000255}. FT TRANSMEM 311 332 Helical. {ECO:0000255}. FT DOMAIN 206 294 Ig-like C1-type. FT REGION 22 111 Alpha-1. FT REGION 112 203 Alpha-2. FT REGION 204 295 Alpha-3. FT REGION 296 310 Connecting peptide. FT CARBOHYD 107 107 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 277 277 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 122 185 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 224 280 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT CONFLICT 87 87 I -> M (in Ref. 3). {ECO:0000305}. FT STRAND 24 33 {ECO:0000244|PDB:1K8D}. FT STRAND 42 49 {ECO:0000244|PDB:1K8D}. FT STRAND 52 58 {ECO:0000244|PDB:1K8D}. FT STRAND 61 63 {ECO:0000244|PDB:1K8D}. FT HELIX 71 73 {ECO:0000244|PDB:1K8D}. FT HELIX 77 105 {ECO:0000244|PDB:1K8D}. FT STRAND 115 124 {ECO:0000244|PDB:1K8D}. FT STRAND 128 139 {ECO:0000244|PDB:1K8D}. FT STRAND 142 147 {ECO:0000244|PDB:1K8D}. FT STRAND 154 156 {ECO:0000244|PDB:1K8D}. FT HELIX 159 170 {ECO:0000244|PDB:1K8D}. FT HELIX 173 182 {ECO:0000244|PDB:1K8D}. FT HELIX 184 195 {ECO:0000244|PDB:1K8D}. FT HELIX 197 200 {ECO:0000244|PDB:1K8D}. FT STRAND 207 214 {ECO:0000244|PDB:1K8D}. FT STRAND 216 232 {ECO:0000244|PDB:1K8D}. FT STRAND 235 240 {ECO:0000244|PDB:1K8D}. FT TURN 246 248 {ECO:0000244|PDB:1K8D}. FT STRAND 249 251 {ECO:0000244|PDB:1K8D}. FT STRAND 258 260 {ECO:0000244|PDB:1K8D}. FT STRAND 262 271 {ECO:0000244|PDB:1K8D}. FT STRAND 278 283 {ECO:0000244|PDB:1K8D}. FT STRAND 287 289 {ECO:0000244|PDB:1K8D}. FT STRAND 291 293 {ECO:0000244|PDB:1K8D}. SQ SEQUENCE 334 AA; 37924 MW; 1E63FAFCCBD6763B CRC64; MALTMLLLLV AAALTLIETR AGQHSLQYFH TAVSRPGLGE PWFISVGYVD DTQFVRFDSD AENPRMEPRA RWMEQEGPEY WERETQIAKG HEQSFRGSLR TAQSYYNQSK GGSHTLQWMY GCDMGSDGRL LRGYLQFAYE GRDYIALNED LKTWTAVDMA AQITRRKWEQ AGIAEKDQAY LEGTCMQSLR RYLQLGKETL LRTDPPKAHV THHPRSYGAV TLRCWALGFY PADITLTWQL NGEELTQDME LVETRPAGDG TFQKWASVVV PLGKEQNYTC HVNHEGLPEP LTLRWGRWEP PPYTVSNMAT IAVVVDLGAV AIIGAVVAFV MNRR // ID HA18_MOUSE Reviewed; 326 AA. AC P14430; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 23-MAY-2018, entry version 131. DE RecName: Full=H-2 class I histocompatibility antigen, Q8 alpha chain; DE Flags: Precursor; GN Name=H2-Q8; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=C57BL/10; RX PubMed=3004940; RA Devlin J.J., Weiss E.H., Paulson M., Flavell R.A.; RT "Duplicated gene pairs and alleles of class I genes in the Qa2 region RT of the murine major histocompatibility complex: a comparison."; RL EMBO J. 4:3203-3207(1985). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X03211; CAA26955.1; -; Genomic_DNA. DR EMBL; X03442; CAA27171.1; -; Genomic_DNA. DR PIR; B24582; B24582. DR UniGene; Mm.486287; -. DR ProteinModelPortal; P14430; -. DR SMR; P14430; -. DR STRING; 10090.ENSMUSP00000109511; -. DR iPTMnet; P14430; -. DR PhosphoSitePlus; P14430; -. DR EPD; P14430; -. DR MaxQB; P14430; -. DR PaxDb; P14430; -. DR PeptideAtlas; P14430; -. DR PRIDE; P14430; -. DR UCSC; uc008chr.1; mouse. DR MGI; MGI:95937; H2-Q8. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR InParanoid; P14430; -. DR PhylomeDB; P14430; -. DR PRO; PR:P14430; -. DR Proteomes; UP000000589; Unplaced. DR CleanEx; MM_H2-Q8; -. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 21 FT CHAIN 22 326 H-2 class I histocompatibility antigen, FT Q8 alpha chain. FT /FTId=PRO_0000018934. FT TOPO_DOM 22 305 Extracellular. {ECO:0000255}. FT TRANSMEM 306 326 Helical. {ECO:0000255}. FT DOMAIN 206 294 Ig-like C1-type. FT REGION 22 111 Alpha-1. FT REGION 112 203 Alpha-2. FT REGION 204 295 Alpha-3. FT REGION 296 305 Connecting peptide. FT CARBOHYD 107 107 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 277 277 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 122 185 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 224 280 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 326 AA; 37411 MW; 22874A2A5C771F98 CRC64; MALTMLLLLV AAALTLIETR AGPHSLRYFH TAVSWPGLVE PRFIIVGYVD DTQFVRFDSD AENPRMEPRA RWMEQEGPEY WERETQKAKG HEESFRVSLR TAQRYYNQSK GGSHTLQWMY GCDVGSDERL LRGYLQFAYE GRDYIALNED LKTWTAADMA AQITLHKWEQ AGIAERDRAY LEGACVQSLR RYLQLRKETL LCTDPPKAHV THHPRSYGAV TLRCWALGFY PADITLTWQL NGEELTQDME LVETRPAGDG TFQKWASVVV PLGKEQNYTC HVNHEGLPEP LTLRWEPPPS TVSNMANVAI LVVLVAWPSL ELWWIL // ID HA19_CANLF Reviewed; 362 AA. AC P18466; DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1990, sequence version 1. DT 23-MAY-2018, entry version 103. DE RecName: Full=DLA class I histocompatibility antigen, A9/A9 alpha chain; DE Flags: Precursor; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2370086; DOI=10.1007/BF02115019; RA Sarmiento U.M., Storb R.; RT "Nucleotide sequence of a dog class I cDNA clone."; RL Immunogenetics 31:400-404(1990). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M32283; AAA30865.1; -; mRNA. DR PIR; A45845; A45845. DR ProteinModelPortal; P18466; -. DR SMR; P18466; -. DR PRIDE; P18466; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000002254; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 24 {ECO:0000255}. FT CHAIN 25 362 DLA class I histocompatibility antigen, FT A9/A9 alpha chain. FT /FTId=PRO_0000018945. FT TOPO_DOM 25 306 Extracellular. {ECO:0000255}. FT TRANSMEM 307 329 Helical. {ECO:0000255}. FT TOPO_DOM 330 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 210 296 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 207 Alpha-2. FT REGION 208 299 Alpha-3. FT REGION 300 306 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 125 189 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 228 284 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 362 AA; 40462 MW; AC893ABD4F4941AA CRC64; MEVVMPRALL VLLSAALALT PTRAGSHSLR YFYTSVSRPG AGDPRFIAVG YVDDTQFVRF DSDAATGRME PRAPWVEQEG PEYWDRQTRT IKETARTFRV DLDTLRGYYN QSEAGSHTRQ TMYGCDLGPD GRLLRGYSQD AYDGADYIAL NEDLRSWTAA DTAAQITQRK WEAAGVAELQ WRNYLETTCV EWLRRYLEMG KETLLRADPP STRVTHHPVS DHEVTLRCWA LGFYPAEITL TWQRDGEDQT QDTEVVDTRP AGDGTFQKWA AVVVPSGQEQ RYTCHVQHEG LPEPITRRWE PSPLSTIVIV SIAALVLLVV AGVIGAVIWR KQRSGGKGPG YSHAARDDSA QGSDVSLTAP RV // ID HA19_MOUSE Reviewed; 200 AA. AC P14431; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 23-MAY-2018, entry version 125. DE RecName: Full=H-2 class I histocompatibility antigen, Q9 alpha chain; DE Flags: Precursor; Fragment; GN Name=H2-Q9; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=C57BL/10; RX PubMed=3004940; RA Devlin J.J., Weiss E.H., Paulson M., Flavell R.A.; RT "Duplicated gene pairs and alleles of class I genes in the Qa2 region RT of the murine major histocompatibility complex: a comparison."; RL EMBO J. 4:3203-3207(1985). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=CAA27172.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X03443; CAA27172.1; ALT_INIT; Genomic_DNA. DR UniGene; Mm.431282; -. DR ProteinModelPortal; P14431; -. DR SMR; P14431; -. DR EPD; P14431; -. DR MaxQB; P14431; -. DR PRIDE; P14431; -. DR MGI; MGI:95938; H2-Q9. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; P14431; -. DR Proteomes; UP000000589; Unplaced. DR GO; GO:0009986; C:cell surface; IDA:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0032398; C:MHC class Ib protein complex; IDA:MGI. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; IDA:MGI. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; IDA:MGI. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0071346; P:cellular response to interferon-gamma; IDA:MGI. DR GO; GO:0051607; P:defense response to virus; IDA:MGI. DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IDA:MGI. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Reference proteome; Signal. FT SIGNAL 1 21 FT CHAIN 22 >200 H-2 class I histocompatibility antigen, FT Q9 alpha chain. FT /FTId=PRO_0000018935. FT TOPO_DOM 22 >200 Extracellular. {ECO:0000255}. FT REGION 22 111 Alpha-1. FT REGION 112 >200 Alpha-2. FT CARBOHYD 107 107 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 122 185 {ECO:0000250}. FT NON_TER 200 200 SQ SEQUENCE 200 AA; 23025 MW; 4C2B7B2D059EA82E CRC64; MALTMLLLLV AAALTLIETR AGQHSLQYFH TAVSRPGLGE PWFISVGYVD DTQFVRFDSD AENPRMEPRA RWMEQEGPEY WERETQIAKG HEQSFRGSLR TAQSYYNQSK GGSHTLQWMY GCDMGSDGRL LRGYLQFAYE GRDYIALNED LKTWTAVDMA AQITRRKWEQ AGIAEKDQAY LEGTCMQSLR RYLELGKETL // ID HA1A_BOVIN Reviewed; 360 AA. AC P13752; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 25-OCT-2017, entry version 104. DE RecName: Full=BOLA class I histocompatibility antigen, alpha chain BL3-6; DE Flags: Precursor; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=3133413; RA Ennis P.D., Jackson A.P., Parham P.; RT "Molecular cloning of bovine class I MHC cDNA."; RL J. Immunol. 141:642-651(1988). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M21044; AAA30640.1; -; mRNA. DR PIR; A27638; A27638. DR UniGene; Bt.102097; -. DR UniGene; Bt.12775; -. DR UniGene; Bt.71409; -. DR ProteinModelPortal; P13752; -. DR SMR; P13752; -. DR PeptideAtlas; P13752; -. DR PRIDE; P13752; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000009136; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 21 {ECO:0000255}. FT CHAIN 22 360 BOLA class I histocompatibility antigen, FT alpha chain BL3-6. FT /FTId=PRO_0000018939. FT TOPO_DOM 22 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 328 Helical. {ECO:0000255}. FT TOPO_DOM 329 360 Cytoplasmic. {ECO:0000255}. FT DOMAIN 206 292 Ig-like C1-type. FT REGION 22 111 Alpha-1. FT REGION 112 203 Alpha-2. FT REGION 204 295 Alpha-3. FT REGION 296 308 Connecting peptide. FT MOD_RES 351 351 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 354 354 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT CARBOHYD 107 107 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 122 185 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 224 280 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 360 AA; 40363 MW; 2399AF055A0485A9 CRC64; MGPRALLLLL SGVLILTETR AGSHSLRYFS TAVSRPGLGE PRYLEVGYVD DTQFVQFDSD APNPRMEPRA RWVEQEGPEY WDRNTRNAKG NAQSFRVNLN TLRGYYNQSE AGSHTLQWMS GCDVGPDGAL RRGFMQYGYD GRDYLALNED LRSWTAGETE AQITKRKWEA AGYAEVQRNY LEGECVEWLR RYLENGKDTL LRADPPKAHV THHPISGREV TLRCWALGFY PEEISLTWQH DGEDQTQDME LVETRPSGDG TFQKWAALVV PSGDEQRYTC RVQHEGLQEP LTLRWEPPQP SFLTMGIIVG LVLLVVTGAV VAGVVICMKK RSGEKGGNYI QASSSDSAQG SDVSLTVPKV // ID HA1A_RABIT Reviewed; 361 AA. AC P01894; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 28-FEB-2018, entry version 96. DE RecName: Full=RLA class I histocompatibility antigen, alpha chain 11/11; DE Flags: Precursor; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6432910; RA Tykocinski M.L., Marche P.N., Max E.E., Kindt T.J.; RT "Rabbit class I MHC genes: cDNA clones define full-length transcripts RT of an expressed gene and a putative pseudogene."; RL J. Immunol. 133:2261-2269(1984). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; K02441; AAA98729.1; -; mRNA. DR PIR; A02193; HLRB. DR RefSeq; NP_001164741.1; NM_001171270.1. DR UniGene; Ocu.2064; -. DR ProteinModelPortal; P01894; -. DR SMR; P01894; -. DR PRIDE; P01894; -. DR GeneID; 100328967; -. DR KEGG; ocu:100328967; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR Proteomes; UP000001811; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000255}. FT CHAIN 25 361 RLA class I histocompatibility antigen, FT alpha chain 11/11. FT /FTId=PRO_0000018941. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 329 Helical. {ECO:0000255}. FT TOPO_DOM 330 361 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 355 355 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 358 358 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 361 AA; 40447 MW; 580B673323C1AE35 CRC64; MGSMAPRTLL LLLAGALTLK DTQAGSHSMR YFYTSVSRPG LGEPRFIIVG YVDDTQFVRF DSDAASPRME QRAPWMGQVE PEYWDQQTQI AKDTAQTFRV NLNTALRYYN QSAAGSHTFQ TMFGCEVWAD GRFFHGYRQY AYDGADYIAL NEDLRSWTAA DTAAQNTQRK WEAAGEAERH RAYLERECVE WLRRYLEMGK ETLQRADPPK AHVTHHPASD REATLRCWAL GFYPAEISLT WQRDGEDQTQ DTELVETRPG GDGTFQKWAA VVVPSGEEQR YTCRVQHEGL PEPLTLTWEP PAQPTALIVG IVAGVLGVLL ILGAVVAVVR RKKHSSDGKG GRYTPAAGGH RDQGSDDSLM P // ID HA1B_BOVIN Reviewed; 364 AA. AC P13753; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 25-OCT-2017, entry version 112. DE RecName: Full=BOLA class I histocompatibility antigen, alpha chain BL3-7; DE Flags: Precursor; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=3133413; RA Ennis P.D., Jackson A.P., Parham P.; RT "Molecular cloning of bovine class I MHC cDNA."; RL J. Immunol. 141:642-651(1988). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M21043; AAA30641.1; -; mRNA. DR PIR; B27638; B27638. DR ProteinModelPortal; P13753; -. DR SMR; P13753; -. DR PeptideAtlas; P13753; -. DR PRIDE; P13753; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000009136; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 27 {ECO:0000255}. FT CHAIN 28 364 BOLA class I histocompatibility antigen, FT alpha chain BL3-7. FT /FTId=PRO_0000018940. FT TOPO_DOM 28 310 Extracellular. {ECO:0000255}. FT TRANSMEM 311 331 Helical. {ECO:0000255}. FT TOPO_DOM 332 364 Cytoplasmic. {ECO:0000255}. FT DOMAIN 212 298 Ig-like C1-type. FT REGION 28 117 Alpha-1. FT REGION 118 209 Alpha-2. FT REGION 210 301 Alpha-3. FT REGION 302 310 Connecting peptide. FT MOD_RES 355 355 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 358 358 Phosphoserine. FT {ECO:0000250|UniProtKB:P01901}. FT CARBOHYD 113 113 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 128 191 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 230 286 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 364 AA; 41513 MW; 622056CF7DCF7873 CRC64; MRVMRVMRPR TLLLLLSGVL VLTETLAGSH SLRYFYTGVS RPGLGEPRFI AVGYVDDTQF VRFDSDAPNP REEPRVPWME QEGPEYWDRN TRIYKDTAQI FRVDLNTLRG YYNQSETGSH NIQAMYGCDV GPDGRLLRGF WQFGYDGRDY IALNEELRSW TAADTAAQIT KRKWEAAGAA ETWRNYLEGE CVEWLRRYLE NGKDTLLRAD PPKAHVTHHS ISDREVTLRC WALGFYPEEI SLTWQREGED QTQDMELVET RPSGDGTFQK WAALVVPSGE EQRYTCRVQH EGLQEPLTLR WEPPQTSFLI MGIIVGLVLL VVALVAGAVI WRKKRSGEKG RIYTQAASSD SAQGSDVSLT VPKV // ID HA1B_MOUSE Reviewed; 369 AA. AC P01901; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 12-SEP-2018, entry version 187. DE RecName: Full=H-2 class I histocompatibility antigen, K-B alpha chain; DE Short=H-2K(B); DE Flags: Precursor; GN Name=H2-K1; Synonyms=H2-K; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RX PubMed=11894963; RA Weiss E., Golden L., Zakut R., Mellor A., Fahrner K., Kvist S., RA Flavell R.A.; RT "The DNA sequence of the H-2K(b) gene: evidence for gene conversion as RT a mechanism for the generation of polymorphism in histocompatibility RT antigens."; RL EMBO J. 2:453-462(1983). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=C57BL/10; RX PubMed=9869916; RA Wang M., Stepkowski S.M., Hebert J.S., Tian L., Yu J., Kahan B.D.; RT "Nucleotide sequences of three H-2K and three H-2D complementary DNA RT clones coding mouse class I MHC heavy chain proteins."; RL Ann. Transplant. 1:26-31(1996). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] OF 87-369. RX PubMed=6954478; DOI=10.1073/pnas.79.10.3270; RA Reyes A.A., Schold M., Itakura K., Wallace R.B.; RT "Isolation of a cDNA clone for the murine transplantation antigen H- RT 2Kb."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3270-3274(1982). RN [4] RP PROTEIN SEQUENCE OF 22-367, AND GLYCOSYLATION AT ASN-107 AND ASN-197. RX PubMed=7306483; DOI=10.1021/bi00524a003; RA Uehara H., Coligan J.E., Nathenson S.G.; RT "Amino acid sequence of the carboxyl-terminal hydrophilic region of RT the H-2Kb MHC alloantigen. Completion of the entire primary structure RT of the H-2Kb molecule."; RL Biochemistry 20:5940-5945(1981). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=17242355; DOI=10.1073/pnas.0609836104; RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; RT "Large-scale phosphorylation analysis of mouse liver."; RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). RN [6] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-107. RX PubMed=19349973; DOI=10.1038/nbt.1532; RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., RA Schiess R., Aebersold R., Watts J.D.; RT "Mass-spectrometric identification and relative quantification of N- RT linked cell surface glycoproteins."; RL Nat. Biotechnol. 27:378-386(2009). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, RC Spleen, and Testis; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [8] RP X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 22-295. RX PubMed=1323877; DOI=10.1126/science.1323877; RA Fremont D.H., Matsumura M., Stura E.A., Peterson P.A., Wilson I.A.; RT "Crystal structures of two viral peptides in complex with murine MHC RT class I H-2Kb."; RL Science 257:919-927(1992). RN [9] RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 22-295 IN COMPLEX WITH CD8A. RX PubMed=9806638; DOI=10.1016/S1074-7613(00)80635-4; RA Kern P.S., Teng M.K., Smolyar A., Liu J.H., Liu J., Hussey R.E., RA Spoerl R., Chang H.-C., Reinherz E.L., Wang J.-H.; RT "Structural basis of CD8 coreceptor function revealed by RT crystallographic analysis of a murine CD8alphaalpha ectodomain RT fragment in complex with H-2Kb."; RL Immunity 9:519-530(1998). RN [10] RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 22-295. RX PubMed=10023770; DOI=10.1016/S1074-7613(00)80006-0; RA Speir J.A., Abdel-Motal U.M., Jondal M., Wilson I.A.; RT "Crystal structure of an MHC class I presented glycopeptide that RT generates carbohydrate-specific CTL."; RL Immunity 10:51-61(1999). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000269|PubMed:9806638}. CC -!- INTERACTION: CC P16879:Fes; NbExp=3; IntAct=EBI-1265227, EBI-771815; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; J00400; AAA39648.1; -; mRNA. DR EMBL; U47328; AAB17606.1; -; mRNA. DR EMBL; V00746; CAA24119.2; -; Genomic_DNA. DR EMBL; V00747; CAA24119.2; JOINED; Genomic_DNA. DR CCDS; CCDS50069.1; -. DR PIR; A90980; HLMSKB. DR RefSeq; NP_001001892.2; NM_001001892.2. DR UniGene; Mm.422886; -. DR UniGene; Mm.439675; -. DR UniGene; Mm.440940; -. DR UniGene; Mm.441651; -. DR UniGene; Mm.466882; -. DR PDB; 1BQH; X-ray; 2.80 A; A/D=22-295. DR PDB; 1FO0; X-ray; 2.50 A; H=22-296. DR PDB; 1FZJ; X-ray; 1.90 A; A=22-295. DR PDB; 1FZK; X-ray; 1.70 A; A=22-295. DR PDB; 1FZM; X-ray; 1.80 A; A=22-295. DR PDB; 1FZO; X-ray; 1.80 A; A=22-295. DR PDB; 1G6R; X-ray; 2.80 A; H/I=22-295. DR PDB; 1G7P; X-ray; 1.50 A; A=22-295. DR PDB; 1G7Q; X-ray; 1.60 A; A=22-295. DR PDB; 1KBG; X-ray; 2.20 A; H=22-295. DR PDB; 1KJ2; X-ray; 2.71 A; H/I=22-298. DR PDB; 1KJ3; X-ray; 2.30 A; H/I=22-299. DR PDB; 1KPU; X-ray; 1.50 A; A=22-295. DR PDB; 1KPV; X-ray; 1.71 A; A=22-295. DR PDB; 1LEG; X-ray; 1.75 A; A=22-295. DR PDB; 1LEK; X-ray; 2.15 A; A=22-295. DR PDB; 1LK2; X-ray; 1.35 A; A=22-295. DR PDB; 1MWA; X-ray; 2.40 A; H/I=22-295. DR PDB; 1N59; X-ray; 2.95 A; A/C=22-297. DR PDB; 1NAM; X-ray; 2.70 A; H=22-296. DR PDB; 1NAN; X-ray; 2.30 A; H/L=22-299. DR PDB; 1OSZ; X-ray; 2.10 A; A=22-295. DR PDB; 1P1Z; X-ray; 3.26 A; A=22-295. DR PDB; 1P4L; X-ray; 2.90 A; A=22-295. DR PDB; 1RJY; X-ray; 1.90 A; A/D=22-301. DR PDB; 1RJZ; X-ray; 2.60 A; A/D=22-301. DR PDB; 1RK0; X-ray; 2.61 A; A=22-295. DR PDB; 1RK1; X-ray; 2.10 A; A=22-295. DR PDB; 1S7Q; X-ray; 1.99 A; A=22-369. DR PDB; 1S7R; X-ray; 2.95 A; A/D=22-369. DR PDB; 1S7S; X-ray; 1.99 A; A=22-369. DR PDB; 1S7T; X-ray; 2.30 A; A/D=22-369. DR PDB; 1T0M; X-ray; 2.00 A; A/D=22-299. DR PDB; 1T0N; X-ray; 1.80 A; A/D=22-299. DR PDB; 1VAC; X-ray; 2.50 A; A=22-295. DR PDB; 1VAD; X-ray; 2.50 A; A=22-295. DR PDB; 1WBZ; X-ray; 2.00 A; A/C=22-296. DR PDB; 2CKB; X-ray; 3.00 A; H/I=22-295. DR PDB; 2CLV; X-ray; 1.90 A; A/H=22-300. DR PDB; 2CLZ; X-ray; 1.90 A; A/H=22-300. DR PDB; 2FO4; X-ray; 2.70 A; A=22-295. DR PDB; 2MHA; X-ray; 2.50 A; A/C=22-291. DR PDB; 2OL3; X-ray; 2.90 A; H=22-300. DR PDB; 2QRI; X-ray; 2.00 A; A/B=22-301. DR PDB; 2QRS; X-ray; 2.00 A; A/B=22-301. DR PDB; 2QRT; X-ray; 1.80 A; A/B=22-301. DR PDB; 2VAA; X-ray; 2.30 A; A=22-295. DR PDB; 2VAB; X-ray; 2.50 A; A=22-295. DR PDB; 2ZSV; X-ray; 1.80 A; A/C=22-299. DR PDB; 2ZSW; X-ray; 2.80 A; A/C/E/G=22-299. DR PDB; 3C8K; X-ray; 2.90 A; A=22-295. DR PDB; 3CVH; X-ray; 2.90 A; A/M=22-295. DR PDB; 3P4M; X-ray; 2.50 A; A/D=22-298. DR PDB; 3P4N; X-ray; 2.50 A; A/D=22-298. DR PDB; 3P4O; X-ray; 2.30 A; A/D=22-298. DR PDB; 3P9L; X-ray; 2.00 A; A/D=22-299. DR PDB; 3P9M; X-ray; 2.00 A; A/D=22-298. DR PDB; 3PAB; X-ray; 2.20 A; A/D=22-299. DR PDB; 3RGV; X-ray; 2.90 A; C=22-296. DR PDB; 3ROL; X-ray; 2.60 A; A/C=22-296. DR PDB; 3ROO; X-ray; 2.00 A; A/C=22-296. DR PDB; 3TID; X-ray; 1.65 A; A=22-297. DR PDB; 3TIE; X-ray; 2.25 A; A/D=22-297. DR PDB; 4HKJ; X-ray; 3.00 A; A/E/I/M=22-301. DR PDB; 4HS3; X-ray; 2.10 A; A=22-297. DR PDB; 4PG9; X-ray; 2.40 A; A=22-299. DR PDB; 4PGB; X-ray; 2.80 A; A/D=22-299. DR PDB; 4PGC; X-ray; 2.30 A; A/D=22-299. DR PDB; 4PGD; X-ray; 2.70 A; A=22-299. DR PDB; 4PGE; X-ray; 2.00 A; A=22-299. DR PDB; 4PV8; X-ray; 2.31 A; A/C=22-299. DR PDB; 4PV9; X-ray; 2.00 A; A/C=22-299. DR PDB; 5OQF; X-ray; 2.27 A; A/B=23-304. DR PDB; 5OQG; X-ray; 1.90 A; A/B=22-304. DR PDB; 5OQH; X-ray; 2.05 A; A/B=22-304. DR PDB; 5OQI; X-ray; 2.40 A; A/B=22-304. DR PDBsum; 1BQH; -. DR PDBsum; 1FO0; -. DR PDBsum; 1FZJ; -. DR PDBsum; 1FZK; -. DR PDBsum; 1FZM; -. DR PDBsum; 1FZO; -. DR PDBsum; 1G6R; -. DR PDBsum; 1G7P; -. DR PDBsum; 1G7Q; -. DR PDBsum; 1KBG; -. DR PDBsum; 1KJ2; -. DR PDBsum; 1KJ3; -. DR PDBsum; 1KPU; -. DR PDBsum; 1KPV; -. DR PDBsum; 1LEG; -. DR PDBsum; 1LEK; -. DR PDBsum; 1LK2; -. DR PDBsum; 1MWA; -. DR PDBsum; 1N59; -. DR PDBsum; 1NAM; -. DR PDBsum; 1NAN; -. DR PDBsum; 1OSZ; -. DR PDBsum; 1P1Z; -. DR PDBsum; 1P4L; -. DR PDBsum; 1RJY; -. DR PDBsum; 1RJZ; -. DR PDBsum; 1RK0; -. DR PDBsum; 1RK1; -. DR PDBsum; 1S7Q; -. DR PDBsum; 1S7R; -. DR PDBsum; 1S7S; -. DR PDBsum; 1S7T; -. DR PDBsum; 1T0M; -. DR PDBsum; 1T0N; -. DR PDBsum; 1VAC; -. DR PDBsum; 1VAD; -. DR PDBsum; 1WBZ; -. DR PDBsum; 2CKB; -. DR PDBsum; 2CLV; -. DR PDBsum; 2CLZ; -. DR PDBsum; 2FO4; -. DR PDBsum; 2MHA; -. DR PDBsum; 2OL3; -. DR PDBsum; 2QRI; -. DR PDBsum; 2QRS; -. DR PDBsum; 2QRT; -. DR PDBsum; 2VAA; -. DR PDBsum; 2VAB; -. DR PDBsum; 2ZSV; -. DR PDBsum; 2ZSW; -. DR PDBsum; 3C8K; -. DR PDBsum; 3CVH; -. DR PDBsum; 3P4M; -. DR PDBsum; 3P4N; -. DR PDBsum; 3P4O; -. DR PDBsum; 3P9L; -. DR PDBsum; 3P9M; -. DR PDBsum; 3PAB; -. DR PDBsum; 3RGV; -. DR PDBsum; 3ROL; -. DR PDBsum; 3ROO; -. DR PDBsum; 3TID; -. DR PDBsum; 3TIE; -. DR PDBsum; 4HKJ; -. DR PDBsum; 4HS3; -. DR PDBsum; 4PG9; -. DR PDBsum; 4PGB; -. DR PDBsum; 4PGC; -. DR PDBsum; 4PGD; -. DR PDBsum; 4PGE; -. DR PDBsum; 4PV8; -. DR PDBsum; 4PV9; -. DR PDBsum; 5OQF; -. DR PDBsum; 5OQG; -. DR PDBsum; 5OQH; -. DR PDBsum; 5OQI; -. DR ProteinModelPortal; P01901; -. DR SMR; P01901; -. DR BioGrid; 200155; 1. DR DIP; DIP-6189N; -. DR IntAct; P01901; 5. DR MINT; P01901; -. DR STRING; 10090.ENSMUSP00000025181; -. DR iPTMnet; P01901; -. DR PhosphoSitePlus; P01901; -. DR SwissPalm; P01901; -. DR EPD; P01901; -. DR PaxDb; P01901; -. DR PeptideAtlas; P01901; -. DR PRIDE; P01901; -. DR Ensembl; ENSMUST00000025181; ENSMUSP00000025181; ENSMUSG00000061232. DR GeneID; 14972; -. DR KEGG; mmu:14972; -. DR UCSC; uc008cap.1; mouse. DR CTD; 14972; -. DR MGI; MGI:95904; H2-K1. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR InParanoid; P01901; -. DR KO; K06751; -. DR OMA; VHEIHER; -. DR OrthoDB; EOG091G09OH; -. DR PhylomeDB; P01901; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; H2-K1; mouse. DR EvolutionaryTrace; P01901; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000061232; Expressed in 279 organ(s), highest expression level in epididymal fat pad. DR CleanEx; MM_H2-K1; -. DR ExpressionAtlas; P01901; baseline and differential. DR Genevisible; P01901; MM. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; IDA:MGI. DR GO; GO:0042277; F:peptide binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0046977; F:TAP binding; ISO:MGI. DR GO; GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IDA:MGI. DR GO; GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; IDA:MGI. DR GO; GO:0042742; P:defense response to bacterium; IDA:MGI. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0048839; P:inner ear development; IDA:MGI. DR GO; GO:0010977; P:negative regulation of neuron projection development; IDA:MGI. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Direct protein sequencing; KW Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I; KW Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 21 {ECO:0000269|PubMed:7306483}. FT CHAIN 22 369 H-2 class I histocompatibility antigen, FT K-B alpha chain. FT /FTId=PRO_0000018928. FT TOPO_DOM 22 305 Extracellular. {ECO:0000255}. FT TRANSMEM 306 328 Helical. {ECO:0000255}. FT TOPO_DOM 329 369 Cytoplasmic. {ECO:0000255}. FT DOMAIN 206 294 Ig-like C1-type. FT REGION 22 111 Alpha-1. FT REGION 112 203 Alpha-2. FT REGION 204 295 Alpha-3. FT REGION 296 305 Connecting peptide. FT MOD_RES 351 351 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 354 354 Phosphoserine. FT {ECO:0000244|PubMed:17242355, FT ECO:0000244|PubMed:21183079}. FT CARBOHYD 107 107 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:19349973, FT ECO:0000269|PubMed:7306483}. FT CARBOHYD 197 197 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:7306483}. FT DISULFID 122 185 FT DISULFID 224 280 FT CONFLICT 217 217 E -> D (in Ref. 4; AA sequence). FT {ECO:0000305}. FT CONFLICT 289 289 E -> Q (in Ref. 4; AA sequence). FT {ECO:0000305}. FT CONFLICT 334 334 N -> A (in Ref. 4; AA sequence). FT {ECO:0000305}. FT CONFLICT 364 364 D -> P (in Ref. 4; AA sequence). FT {ECO:0000305}. FT STRAND 24 33 {ECO:0000244|PDB:1LK2}. FT STRAND 38 40 {ECO:0000244|PDB:1LK2}. FT STRAND 42 49 {ECO:0000244|PDB:1LK2}. FT STRAND 52 58 {ECO:0000244|PDB:1LK2}. FT STRAND 61 63 {ECO:0000244|PDB:1LK2}. FT STRAND 67 70 {ECO:0000244|PDB:3TID}. FT HELIX 71 75 {ECO:0000244|PDB:1LK2}. FT HELIX 78 105 {ECO:0000244|PDB:1LK2}. FT STRAND 110 112 {ECO:0000244|PDB:1G7P}. FT STRAND 115 124 {ECO:0000244|PDB:1LK2}. FT STRAND 126 128 {ECO:0000244|PDB:1G6R}. FT STRAND 130 139 {ECO:0000244|PDB:1LK2}. FT STRAND 142 147 {ECO:0000244|PDB:1LK2}. FT TURN 149 152 {ECO:0000244|PDB:2MHA}. FT STRAND 154 158 {ECO:0000244|PDB:1LK2}. FT HELIX 159 171 {ECO:0000244|PDB:1LK2}. FT HELIX 173 182 {ECO:0000244|PDB:1LK2}. FT HELIX 184 195 {ECO:0000244|PDB:1LK2}. FT HELIX 197 200 {ECO:0000244|PDB:1LK2}. FT STRAND 207 214 {ECO:0000244|PDB:1LK2}. FT STRAND 216 232 {ECO:0000244|PDB:1LK2}. FT STRAND 235 240 {ECO:0000244|PDB:1LK2}. FT STRAND 243 245 {ECO:0000244|PDB:2MHA}. FT TURN 246 248 {ECO:0000244|PDB:1LK2}. FT STRAND 249 251 {ECO:0000244|PDB:1T0N}. FT STRAND 258 260 {ECO:0000244|PDB:1LK2}. FT STRAND 262 271 {ECO:0000244|PDB:1LK2}. FT HELIX 275 277 {ECO:0000244|PDB:1LK2}. FT STRAND 278 283 {ECO:0000244|PDB:1LK2}. FT STRAND 287 289 {ECO:0000244|PDB:2QRT}. FT STRAND 291 293 {ECO:0000244|PDB:1LK2}. SQ SEQUENCE 369 AA; 41302 MW; 3D2F125318193443 CRC64; MVPCTLLLLL AAALAPTQTR AGPHSLRYFV TAVSRPGLGE PRYMEVGYVD DTEFVRFDSD AENPRYEPRA RWMEQEGPEY WERETQKAKG NEQSFRVDLR TLLGYYNQSK GGSHTIQVIS GCEVGSDGRL LRGYQQYAYD GCDYIALNED LKTWTAADMA ALITKHKWEQ AGEAERLRAY LEGTCVEWLR RYLKNGNATL LRTDSPKAHV THHSRPEDKV TLRCWALGFY PADITLTWQL NGEELIQDME LVETRPAGDG TFQKWASVVV PLGKEQYYTC HVYHQGLPEP LTLRWEPPPS TVSNMATVAV LVVLGAAIVT GAVVAFVMKM RRRNTGGKGG DYALAPGSQT SDLSLPDCKV MVHDPHSLA // ID HA1B_RABIT Reviewed; 361 AA. AC P06140; DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1988, sequence version 1. DT 28-FEB-2018, entry version 94. DE RecName: Full=RLA class I histocompatibility antigen, alpha chain 19-1; DE Flags: Precursor; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=3917974; DOI=10.1007/BF00372243; RA Marche P.N., Tykocinski M.L., Max E.E., Kindt T.J.; RT "Structure of a functional rabbit class I MHC gene: similarity to RT human class I genes."; RL Immunogenetics 21:71-82(1985). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; K02819; AAA98730.1; -; Genomic_DNA. DR PIR; I46858; I46858. DR UniGene; Ocu.2064; -. DR ProteinModelPortal; P06140; -. DR SMR; P06140; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000001811; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000255}. FT CHAIN 25 361 RLA class I histocompatibility antigen, FT alpha chain 19-1. FT /FTId=PRO_0000018942. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 329 Helical. {ECO:0000255}. FT TOPO_DOM 330 361 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT MOD_RES 355 355 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 358 358 Phosphoserine. FT {ECO:0000250|UniProtKB:P01901}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 361 AA; 40455 MW; C06FBD8B87ED0546 CRC64; MGSIPPRTLL LLLAGALTLK DTQAGSHSMR YFYTSVSRPG LGEPRFIIVG YVDDTQFVRF DSDAASPRME QRAPWMGQVE PEYWDQQTQI AKDTAQTFRV NLNTALRYYN QSAAGSHTFQ TMFGCEVWAD GRFFHGYRQY AYDGADYIAL NEDLRSWTAA DTAAQNTQRK WEAAGEAERH RAYLERECVE WLRRYLEMGK ETLQRADPPK AHVTHHPASD REATLRCWAL GFYPAEISLT WQRDGEDQTQ DTELVETRPG GDGTFQKWAA VVVPSGEEQR YTCRVQHEGL PEPLTLTWEP PAQPTALIVG IVAGVLGVLL ILGAVVAVVR RKKHSSDGKG GRYTPAAGGH RDQGSDDSLM P // ID HA1D_MOUSE Reviewed; 368 AA. AC P01902; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 20-JUN-2018, entry version 153. DE RecName: Full=H-2 class I histocompatibility antigen, K-D alpha chain; DE Short=H-2K(D); DE Flags: Precursor; GN Name=H2-K1; Synonyms=H2-K; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=11894934; RA Kvist S., Roberts L., Dobberstein B.; RT "Mouse histocompatibility genes: structure and organisation of a Kd RT gene."; RL EMBO J. 2:245-254(1983). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=BALB/cJ; RX PubMed=6298749; DOI=10.1093/nar/11.5.1567; RA Lalanne J.-L., Delarbre C., Gachelin G., Kourilsky P.; RT "A cDNA clone containing the entire coding sequence of a mouse H-2Kd RT histocompatibility antigen."; RL Nucleic Acids Res. 11:1567-1577(1983). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=NOD/LT; RA Girgis K.R., Capra D.J., Stroynowski I.; RL Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=BALB/cJ; RX PubMed=9869916; RA Wang M., Stepkowski S.M., Hebert J.S., Tian L., Yu J., Kahan B.D.; RT "Nucleotide sequences of three H-2K and three H-2D complementary DNA RT clones coding mouse class I MHC heavy chain proteins."; RL Ann. Transplant. 1:26-31(1996). RN [5] RP PROTEIN SEQUENCE OF 22-119. RX PubMed=7018573; DOI=10.1021/bi00514a049; RA Kimball E.S., Nathenson S.G., Coligan J.E.; RT "Amino acid sequence of residues 1-98 of the K-2Kb murine major RT histocompatibility alloantigen: comparison with H-2Kb and H-2db RT reveals extensive localized differences."; RL Biochemistry 20:3301-3308(1981). RN [6] RP GLYCOSYLATION AT ASN-107 AND ASN-277. RX PubMed=3980466; RA Swiedler S.J., Freed J.H., Tarentino A.L., Plummer T.H. Jr., RA Hart G.W.; RT "Oligosaccharide microheterogeneity of the murine major RT histocompatibility antigens. Reproducible site-specific patterns of RT sialylation and branching in asparagine-linked oligosaccharides."; RL J. Biol. Chem. 260:4046-4054(1985). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=17242355; DOI=10.1073/pnas.0609836104; RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; RT "Large-scale phosphorylation analysis of mouse liver."; RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). RN [8] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-353, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006; RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M., RA Thibault P.; RT "The phagosomal proteome in interferon-gamma-activated macrophages."; RL Immunity 30:143-154(2009). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350 AND SER-353, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen, and RC Testis; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; J00402; AAA39652.1; -; mRNA. DR EMBL; L36065; AAA89205.1; -; mRNA. DR EMBL; U47329; AAB17607.1; -; mRNA. DR PIR; A90977; HLMSKD. DR UniGene; Mm.422886; -. DR UniGene; Mm.439675; -. DR UniGene; Mm.440940; -. DR UniGene; Mm.441651; -. DR UniGene; Mm.466882; -. DR PDB; 1VGK; X-ray; 2.06 A; A=22-295. DR PDB; 2FWO; X-ray; 2.60 A; A=22-304. DR PDB; 3NWM; X-ray; 2.70 A; A=22-295. DR PDB; 4WDI; X-ray; 2.31 A; A/D=22-296. DR PDB; 4Z76; X-ray; 1.88 A; A/D=22-296. DR PDB; 4Z77; X-ray; 1.85 A; A/D=22-296. DR PDB; 4Z78; X-ray; 2.30 A; A/D/G=22-296. DR PDB; 5GR7; X-ray; 2.40 A; A=22-295. DR PDB; 5GSB; X-ray; 1.80 A; A=22-295. DR PDB; 5GSR; X-ray; 2.20 A; A/C=22-295. DR PDB; 5GSV; X-ray; 2.00 A; A=22-295. DR PDB; 5GSX; X-ray; 2.50 A; A/D=22-295. DR PDB; 5TRZ; X-ray; 2.25 A; A/C=23-297. DR PDB; 5TS1; X-ray; 2.30 A; A/C/E/G=23-297. DR PDBsum; 1VGK; -. DR PDBsum; 2FWO; -. DR PDBsum; 3NWM; -. DR PDBsum; 4WDI; -. DR PDBsum; 4Z76; -. DR PDBsum; 4Z77; -. DR PDBsum; 4Z78; -. DR PDBsum; 5GR7; -. DR PDBsum; 5GSB; -. DR PDBsum; 5GSR; -. DR PDBsum; 5GSV; -. DR PDBsum; 5GSX; -. DR PDBsum; 5TRZ; -. DR PDBsum; 5TS1; -. DR ProteinModelPortal; P01902; -. DR SMR; P01902; -. DR IntAct; P01902; 1. DR iPTMnet; P01902; -. DR PhosphoSitePlus; P01902; -. DR EPD; P01902; -. DR MaxQB; P01902; -. DR PRIDE; P01902; -. DR MGI; MGI:95904; H2-K1. DR HOVERGEN; HBG016709; -. DR ChiTaRS; H2-K1; mouse. DR EvolutionaryTrace; P01902; -. DR Proteomes; UP000000589; Unplaced. DR CleanEx; MM_H2-K1; -. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; IDA:MGI. DR GO; GO:0042277; F:peptide binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0046977; F:TAP binding; ISO:MGI. DR GO; GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IDA:MGI. DR GO; GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; IDA:MGI. DR GO; GO:0042742; P:defense response to bacterium; IDA:MGI. DR GO; GO:0048839; P:inner ear development; IDA:MGI. DR GO; GO:0010977; P:negative regulation of neuron projection development; IDA:MGI. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Direct protein sequencing; KW Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I; KW Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 21 {ECO:0000269|PubMed:7018573}. FT CHAIN 22 368 H-2 class I histocompatibility antigen, FT K-D alpha chain. FT /FTId=PRO_0000018929. FT TOPO_DOM 22 305 Extracellular. {ECO:0000255}. FT TRANSMEM 306 328 Helical. {ECO:0000255}. FT TOPO_DOM 329 368 Cytoplasmic. {ECO:0000255}. FT DOMAIN 206 294 Ig-like C1-type. FT REGION 22 111 Alpha-1. FT REGION 112 203 Alpha-2. FT REGION 204 295 Alpha-3. FT REGION 296 305 Connecting peptide. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000244|PubMed:21183079}. FT MOD_RES 353 353 Phosphoserine. FT {ECO:0000244|PubMed:19144319, FT ECO:0000244|PubMed:21183079}. FT CARBOHYD 107 107 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:3980466, FT ECO:0000269|PubMed:6298749}. FT CARBOHYD 197 197 N-linked (GlcNAc...) asparagine. FT {ECO:0000255, FT ECO:0000303|PubMed:6298749}. FT CARBOHYD 277 277 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:3980466}. FT DISULFID 122 185 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 224 280 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT CONFLICT 135 135 Q -> H (in Ref. 2; AAA39652). FT {ECO:0000305}. FT STRAND 24 35 {ECO:0000244|PDB:5GSB}. FT TURN 36 38 {ECO:0000244|PDB:5GSB}. FT STRAND 39 49 {ECO:0000244|PDB:5GSB}. FT STRAND 52 58 {ECO:0000244|PDB:5GSB}. FT STRAND 61 63 {ECO:0000244|PDB:5GSB}. FT STRAND 67 70 {ECO:0000244|PDB:5GSB}. FT HELIX 71 73 {ECO:0000244|PDB:5GSB}. FT HELIX 78 105 {ECO:0000244|PDB:5GSB}. FT STRAND 110 112 {ECO:0000244|PDB:3NWM}. FT STRAND 115 124 {ECO:0000244|PDB:5GSB}. FT STRAND 129 139 {ECO:0000244|PDB:5GSB}. FT STRAND 142 147 {ECO:0000244|PDB:5GSB}. FT STRAND 154 158 {ECO:0000244|PDB:5GSB}. FT HELIX 159 171 {ECO:0000244|PDB:5GSB}. FT HELIX 173 182 {ECO:0000244|PDB:5GSB}. FT HELIX 184 195 {ECO:0000244|PDB:5GSB}. FT HELIX 197 200 {ECO:0000244|PDB:5GSB}. FT STRAND 202 204 {ECO:0000244|PDB:4Z77}. FT STRAND 207 214 {ECO:0000244|PDB:5GSB}. FT STRAND 216 232 {ECO:0000244|PDB:5GSB}. FT STRAND 235 240 {ECO:0000244|PDB:5GSB}. FT STRAND 243 245 {ECO:0000244|PDB:5GSV}. FT HELIX 246 248 {ECO:0000244|PDB:4Z77}. FT STRAND 249 251 {ECO:0000244|PDB:5GSV}. FT STRAND 258 260 {ECO:0000244|PDB:5GSB}. FT STRAND 262 271 {ECO:0000244|PDB:5GSB}. FT HELIX 275 277 {ECO:0000244|PDB:5GSB}. FT STRAND 278 283 {ECO:0000244|PDB:5GSB}. FT STRAND 287 289 {ECO:0000244|PDB:4Z76}. FT STRAND 291 293 {ECO:0000244|PDB:5GSB}. SQ SEQUENCE 368 AA; 41490 MW; 4C83897CBCF7C6E5 CRC64; MAPCTLLLLL AAALAPTQTR AGPHSLRYFV TAVSRPGLGE PRFIAVGYVD DTQFVRFDSD ADNPRFEPRA PWMEQEGPEY WEEQTQRAKS DEQWFRVSLR TAQRYYNQSK GGSHTFQRMF GCDVGSDWRL LRGYQQFAYD GRDYIALNED LKTWTAADTA ALITRRKWEQ AGDAEYYRAY LEGECVEWLR RYLELGNETL LRTDSPKAHV TYHPRSQVDV TLRCWALGFY PADITLTWQL NGEDLTQDME LVETRPAGDG TFQKWAAVVV PLGKEQNYTC HVHHKGLPEP LTLRWKLPPS TVSNTVIIAV LVVLGAAIVT GAVVAFVMKM RRNTGGKGVN YALAPGSQTS DLSLPDGKVM VHDPHSLA // ID HA1F_CHICK Reviewed; 345 AA. AC P15979; DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1990, sequence version 1. DT 25-OCT-2017, entry version 114. DE RecName: Full=Class I histocompatibility antigen, F10 alpha chain; DE AltName: Full=B-F histocompatibility F10 antigen; DE AltName: Full=B-F-beta-IV; DE AltName: Full=B12; DE Flags: Precursor; OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Phasianinae; Gallus. OX NCBI_TaxID=9031; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=B12; TISSUE=Liver; RX PubMed=3141149; RA Guillemot F., Billault A., Pourquie O., Behar G., Chausse A.M., RA Zoorob R., Kreibich G., Auffray C.; RT "A molecular map of the chicken major histocompatibility complex: the RT class II beta genes are closely linked to the class I genes and the RT nucleolar organizer."; RL EMBO J. 7:2775-2785(1988). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=2370087; DOI=10.1007/BF02115020; RA Kroemer G., Zoorob R., Auffray C.; RT "Structure and expression of a chicken MHC class I gene."; RL Immunogenetics 31:405-409(1990). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X12780; CAA31272.1; -; mRNA. DR EMBL; M31012; AAA48947.1; -; Genomic_DNA. DR PIR; A45846; HLCHB4. DR UniGene; Gga.33600; -. DR UniGene; Gga.4973; -. DR ProteinModelPortal; P15979; -. DR SMR; P15979; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000000539; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 22 {ECO:0000255}. FT CHAIN 23 345 Class I histocompatibility antigen, F10 FT alpha chain. FT /FTId=PRO_0000018946. FT TOPO_DOM 23 301 Extracellular. {ECO:0000255}. FT TRANSMEM 302 324 Helical. {ECO:0000255}. FT TOPO_DOM 325 345 Cytoplasmic. FT DOMAIN 204 293 Ig-like C1-type. FT REGION 23 110 Alpha-1. FT REGION 111 201 Alpha-2. FT REGION 202 292 Alpha-3. FT REGION 293 301 Connecting peptide. FT CARBOHYD 59 59 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 107 107 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 121 183 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 221 277 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT CONFLICT 339 339 P -> PDREGGSSSSST (in Ref. 2; AAA48947). FT {ECO:0000305}. SQ SEQUENCE 345 AA; 38246 MW; 430DCCF8091B69A4 CRC64; MGPCGALGLG LLLAAVCGAA APELHTLRYI QTAMTDPGPG QPWFVTVGYV DGELFVHYNS TARRYVPRTE WIAAKADQQY WDGQTQIGQG NEQIDRENLG ILQRRYNQTG GSHTVQWMYG CDILEGGPIR GYYQMAYDGR DFTAFDKGTM TFTAAVPEAV PTKRKWEEES EPERWKNYLE ETCVEWLRRY VEYGKAELGR RERPEVRVWG KEADGILTLS CRAHGFYPRP IVVSWLKDGA VRGQDAHSGG IVPNGDGTYH TWVTIDAQPG DGDKYQCRVE HASLPQPGLY SWEPPQPNLV PIVAGVAVAI VAIAIMVGVG FIIYRRHAGK KGKGYNIAPG SNPAI // ID HA1K_MOUSE Reviewed; 369 AA. AC P04223; O19459; Q31165; Q31192; Q95458; DT 20-MAR-1987, integrated into UniProtKB/Swiss-Prot. DT 20-MAR-1987, sequence version 1. DT 20-JUN-2018, entry version 155. DE RecName: Full=H-2 class I histocompatibility antigen, K-K alpha chain; DE Short=H-2K(K); DE Flags: Precursor; GN Name=H2-K1; Synonyms=H2-K; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). RX PubMed=6096831; DOI=10.1093/nar/12.24.9473; RA Arnold B., Burgert H.-G., Archibald A.L., Kvist S.; RT "Complete nucleotide sequence of the murine H-2Kk gene. Comparison of RT three H-2K locus alleles."; RL Nucleic Acids Res. 12:9473-9487(1984). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). RC STRAIN=C3H/HeJ; RX PubMed=3680952; RA Watts S., Vogel J.M., Harriman W.D., Itoh T., Stauss H.J., RA Goodenow R.S.; RT "DNA sequence analysis of the C3H H-2Kk and H-2Dk loci. Evolutionary RT relationships to H-2 genes from four other mouse strains."; RL J. Immunol. 139:3878-3885(1987). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). RC STRAIN=C3H/HeJ; TISSUE=Splenocyte; RX PubMed=9869916; RA Wang M., Stepkowski S.M., Hebert J.S., Tian L., Yu J., Kahan B.D.; RT "Nucleotide sequences of three H-2K and three H-2D complementary DNA RT clones coding mouse class I MHC heavy chain proteins."; RL Ann. Transplant. 1:26-31(1996). RN [4] RP NUCLEOTIDE SEQUENCE OF 1-359. RC STRAIN=C3H/HeN; RX PubMed=3335396; DOI=10.1007/BF00351091; RA Minamide L.S., Callahan G.N., Grosveld F.G., Hui K.M.; RT "The nucleotide sequence of the H-2K gene of C3Hf/HeN mice."; RL Immunogenetics 27:148-152(1988). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 13-369 (ISOFORM 2). RX PubMed=3840763; DOI=10.1016/0378-1119(85)90223-9; RA Reddy E.S., Pan J.Y.; RT "Molecular cloning and sequencing of H-2Kk cDNA: comparison with other RT H-2 genes and evidence for alternative splicing."; RL Gene 38:239-244(1985). RN [6] RP NUCLEOTIDE SEQUENCE OF 22-313. RX PubMed=3374494; DOI=10.1016/0161-5890(88)90018-1; RA Martinko J.M., Solheim J.C., Geliebter J.; RT "The H-2Kkml mutation: a single nucleotide substitution is responsible RT for multiple functional differences in a class I MHC molecule."; RL Mol. Immunol. 25:267-274(1988). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=17242355; DOI=10.1073/pnas.0609836104; RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; RT "Large-scale phosphorylation analysis of mouse liver."; RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). RN [8] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-107. RC TISSUE=Myoblast; RX PubMed=19656770; DOI=10.1074/mcp.M900195-MCP200; RA Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., RA Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., RA Wollscheid B.; RT "The mouse C2C12 myoblast cell surface N-linked glycoproteome: RT identification, glycosite occupancy, and membrane orientation."; RL Mol. Cell. Proteomics 8:2555-2569(2009). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, PHOSPHORYLATION RP [LARGE SCALE ANALYSIS] AT SER-351 AND SER-354 (ISOFORM 2), AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen, RC and Testis; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=P04223-1; Sequence=Displayed; CC Name=2; CC IsoId=P04223-2; Sequence=VSP_011855; CC Note=No experimental confirmation available. Contains a CC phosphoserine at position 354. Contains a phosphoserine at CC position 351. {ECO:0000244|PubMed:21183079}; CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01652; CAA25816.1; -; Genomic_DNA. DR EMBL; M18525; AAA53202.1; -; Genomic_DNA. DR EMBL; U47330; AAB17608.1; -; mRNA. DR EMBL; M18964; AAA39568.1; -; Genomic_DNA. DR EMBL; M11975; AAA39654.1; -; mRNA. DR EMBL; M34932; AAA39596.1; -; mRNA. DR PIR; A02203; HLMSKK. DR UniGene; Mm.422886; -. DR UniGene; Mm.439675; -. DR UniGene; Mm.440940; -. DR UniGene; Mm.441651; -. DR UniGene; Mm.466882; -. DR PDB; 1ZT1; X-ray; 2.50 A; A=22-297. DR PDB; 1ZT7; X-ray; 3.00 A; A/C=22-296. DR PDBsum; 1ZT1; -. DR PDBsum; 1ZT7; -. DR ProteinModelPortal; P04223; -. DR SMR; P04223; -. DR iPTMnet; P04223; -. DR PhosphoSitePlus; P04223; -. DR MaxQB; P04223; -. DR PeptideAtlas; P04223; -. DR PRIDE; P04223; -. DR MGI; MGI:95904; H2-K1. DR HOVERGEN; HBG016709; -. DR ChiTaRS; H2-K1; mouse. DR EvolutionaryTrace; P04223; -. DR Proteomes; UP000000589; Unplaced. DR CleanEx; MM_H2-K1; -. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; IDA:MGI. DR GO; GO:0042277; F:peptide binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0046977; F:TAP binding; ISO:MGI. DR GO; GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IDA:MGI. DR GO; GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; IDA:MGI. DR GO; GO:0042742; P:defense response to bacterium; IDA:MGI. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0048839; P:inner ear development; IDA:MGI. DR GO; GO:0010977; P:negative regulation of neuron projection development; IDA:MGI. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Complete proteome; Disulfide bond; KW Glycoprotein; Immunity; Membrane; MHC I; Phosphoprotein; Polymorphism; KW Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 21 FT CHAIN 22 369 H-2 class I histocompatibility antigen, FT K-K alpha chain. FT /FTId=PRO_0000018930. FT TOPO_DOM 22 305 Extracellular. {ECO:0000255}. FT TRANSMEM 306 328 Helical. {ECO:0000255}. FT TOPO_DOM 329 369 Cytoplasmic. {ECO:0000255}. FT DOMAIN 206 294 Ig-like C1-type. FT REGION 22 111 Alpha-1. FT REGION 112 203 Alpha-2. FT REGION 204 295 Alpha-3. FT REGION 296 305 Connecting peptide. FT MOD_RES 351 351 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 354 354 Phosphoserine. FT {ECO:0000244|PubMed:17242355, FT ECO:0000244|PubMed:21183079}. FT CARBOHYD 107 107 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:19656770}. FT CARBOHYD 197 197 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 122 185 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 224 280 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VAR_SEQ 360 369 VMVHDPHSLA -> A (in isoform 2). FT {ECO:0000303|PubMed:3840763, FT ECO:0000303|PubMed:9869916}. FT /FTId=VSP_011855. FT VARIANT 173 173 D -> A. FT CONFLICT 50 50 D -> E (in Ref. 5; AAA39654). FT {ECO:0000305}. FT CONFLICT 98 98 N -> S (in Ref. 2; AAA53202). FT {ECO:0000305}. FT STRAND 23 33 {ECO:0000244|PDB:1ZT1}. FT TURN 36 38 {ECO:0000244|PDB:1ZT1}. FT STRAND 42 49 {ECO:0000244|PDB:1ZT1}. FT STRAND 52 59 {ECO:0000244|PDB:1ZT1}. FT STRAND 61 63 {ECO:0000244|PDB:1ZT1}. FT STRAND 67 70 {ECO:0000244|PDB:1ZT7}. FT HELIX 71 73 {ECO:0000244|PDB:1ZT1}. FT HELIX 78 105 {ECO:0000244|PDB:1ZT1}. FT STRAND 110 112 {ECO:0000244|PDB:1ZT1}. FT STRAND 115 124 {ECO:0000244|PDB:1ZT1}. FT STRAND 128 139 {ECO:0000244|PDB:1ZT1}. FT STRAND 142 147 {ECO:0000244|PDB:1ZT1}. FT STRAND 154 158 {ECO:0000244|PDB:1ZT1}. FT HELIX 159 170 {ECO:0000244|PDB:1ZT1}. FT HELIX 173 182 {ECO:0000244|PDB:1ZT1}. FT HELIX 184 193 {ECO:0000244|PDB:1ZT1}. FT TURN 196 199 {ECO:0000244|PDB:1ZT7}. FT STRAND 207 214 {ECO:0000244|PDB:1ZT1}. FT STRAND 216 232 {ECO:0000244|PDB:1ZT1}. FT STRAND 235 240 {ECO:0000244|PDB:1ZT1}. FT STRAND 249 251 {ECO:0000244|PDB:1ZT7}. FT STRAND 258 260 {ECO:0000244|PDB:1ZT1}. FT STRAND 262 271 {ECO:0000244|PDB:1ZT1}. FT HELIX 275 277 {ECO:0000244|PDB:1ZT1}. FT STRAND 278 283 {ECO:0000244|PDB:1ZT1}. FT STRAND 291 293 {ECO:0000244|PDB:1ZT1}. SQ SEQUENCE 369 AA; 41646 MW; 9533CF96600A595C CRC64; MAPCMLLLLL AAALAPTQTR AGPHSLRYFH TAVSRPGLGK PRFISVGYVD DTQFVRFDSD AENPRYEPRV RWMEQVEPEY WERNTQIAKG NEQIFRVNLR TALRYYNQSA GGSHTFQRMY GCEVGSDWRL LRGYEQYAYD GCDYIALNED LKTWTAADMA ALITKHKWEQ AGDAERDRAY LEGTCVEWLR RYLQLGNATL PRTDSPKAHV TRHSRPEDKV TLRCWALGFY PADITLTWQL NGEELTQDME LVETRPAGDG TFQKWASVVV PLGKEQYYTC HVYHQGLPEP LTLRWEPPPS TVSNTVIIAV LVVLGAAIVT GAVVAFVMKM RRRNTGGKGG DYALAPGSQT SDLSLPDCKV MVHDPHSLA // ID HA1L_MOUSE Reviewed; 362 AA. AC P01897; Q31195; Q31196; Q31197; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1998, sequence version 2. DT 12-SEP-2018, entry version 168. DE RecName: Full=H-2 class I histocompatibility antigen, L-D alpha chain; DE Flags: Precursor; GN Name=H2-L; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1705528; DOI=10.1016/0378-1119(91)90054-F; RA Joly E., Oldstone M.B.; RT "Generation of a functional cDNA encoding the LdH2 class-I molecule by RT using a single-LTR retroviral shuttle vector."; RL Gene 97:213-221(1991). RN [2] RP NUCLEOTIDE SEQUENCE (CLONE 27.5). RC STRAIN=BALB/cJ; TISSUE=Sperm; RX PubMed=7058332; DOI=10.1126/science.7058332; RA Moore K.W., Sher B.T., Sun Y.H., Eakle K.A., Hood L.E.; RT "DNA sequence of a gene encoding a BALB/c mouse Ld transplantation RT antigen."; RL Science 215:679-682(1982). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=BALB/cJ; TISSUE=Sperm; RX PubMed=6604582; DOI=10.1016/0092-8674(83)90386-0; RA Zuniga M.C., Malissen B., McMillan M., Brayton P.R., Clark S.S., RA Forman J., Hood L.E.; RT "Expression and function of transplantation antigens with altered or RT deleted cytoplasmic domains."; RL Cell 34:535-544(1983). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-311 AND 339-348. RX PubMed=6952248; DOI=10.1073/pnas.79.6.1994; RA Evans G.A., Margulies D.H., Camerini-Otero R.D., Ozato K., RA Seidman J.G.; RT "Structure and expression of a mouse major histocompatibility antigen RT gene, H-2Ld."; RL Proc. Natl. Acad. Sci. U.S.A. 79:1994-1998(1982). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 205-362 (CLONE PH-2D-3). RX PubMed=6895103; DOI=10.1038/292078a0; RA Bregegere F., Abastado J.P., Kvist S., Rask L., Lalanne J.-L., RA Garoff H., Cami B., Wiman K.G., Larhammar D., Peterson P.A., RA Gachelin G., Kourilsky P., Dobberstein B.; RT "Structure of C-terminal half of two H-2 antigens from cloned mRNA."; RL Nature 292:78-81(1981). RN [6] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 25-293. RX PubMed=9192660; DOI=10.1073/pnas.94.13.6880; RA Balendiran G.K., Solheim J.C., Young A.C., Hansen T.H., RA Nathenson S.G., Sacchettini J.C.; RT "The three-dimensional structure of an H-2Ld-peptide complex explains RT the unique interaction of Ld with beta-2 microglobulin and peptide."; RL Proc. Natl. Acad. Sci. U.S.A. 94:6880-6885(1997). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=CAA24126.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M33151; AAA39659.1; -; mRNA. DR EMBL; V00749; CAA24126.1; ALT_INIT; Genomic_DNA. DR EMBL; V00750; CAA24127.1; -; Genomic_DNA. DR EMBL; V00751; CAA24128.1; -; Genomic_DNA. DR EMBL; V00752; CAA24129.1; ALT_SEQ; Genomic_DNA. DR EMBL; L00129; AAA39662.1; -; Genomic_DNA. DR EMBL; J00394; AAA39578.1; -; mRNA. DR EMBL; L00128; AAA39661.1; -; Genomic_DNA. DR EMBL; L00127; AAA39661.1; JOINED; Genomic_DNA. DR PIR; B60854; B60854. DR PIR; C60854; C60854. DR PIR; I54069; HLMSLD. DR UniGene; Mm.439675; -. DR PDB; 1LD9; X-ray; 2.40 A; A/D=25-292. DR PDB; 1LDP; X-ray; 3.10 A; H=25-296. DR PDB; 2E7L; X-ray; 2.50 A; E/F=25-205. DR PDB; 2OI9; X-ray; 2.35 A; A=25-203. DR PDB; 3E2H; X-ray; 3.80 A; A=25-199. DR PDB; 3E3Q; X-ray; 2.95 A; A/B/H/L/P/U/Y/c=25-199. DR PDB; 3ERY; X-ray; 1.95 A; A/B=25-198. DR PDB; 3TF7; X-ray; 2.75 A; A/E=25-203. DR PDB; 3TFK; X-ray; 2.75 A; A=25-203. DR PDB; 3TJH; X-ray; 2.12 A; A=25-203. DR PDB; 3TPU; X-ray; 3.10 A; E/I/K/Q=25-203. DR PDB; 3UO1; X-ray; 1.64 A; P=70-78. DR PDB; 3UYR; X-ray; 1.70 A; P=70-77. DR PDB; 3V4U; X-ray; 1.64 A; P=70-78. DR PDB; 3V52; X-ray; 1.70 A; P=70-77. DR PDB; 3VJ6; X-ray; 1.90 A; P=3-11. DR PDB; 4MS8; X-ray; 1.92 A; A=25-203. DR PDB; 4MVB; X-ray; 3.09 A; A=25-203. DR PDB; 4MXQ; X-ray; 2.60 A; A=25-203. DR PDB; 4N0C; X-ray; 2.90 A; A/E=25-203. DR PDB; 4N5E; X-ray; 3.06 A; A=25-203. DR PDB; 4NHU; X-ray; 2.90 A; E/G=25-204. DR PDB; 5VCL; X-ray; 2.05 A; P=3-11. DR PDBsum; 1LD9; -. DR PDBsum; 1LDP; -. DR PDBsum; 2E7L; -. DR PDBsum; 2OI9; -. DR PDBsum; 3E2H; -. DR PDBsum; 3E3Q; -. DR PDBsum; 3ERY; -. DR PDBsum; 3TF7; -. DR PDBsum; 3TFK; -. DR PDBsum; 3TJH; -. DR PDBsum; 3TPU; -. DR PDBsum; 3UO1; -. DR PDBsum; 3UYR; -. DR PDBsum; 3V4U; -. DR PDBsum; 3V52; -. DR PDBsum; 3VJ6; -. DR PDBsum; 4MS8; -. DR PDBsum; 4MVB; -. DR PDBsum; 4MXQ; -. DR PDBsum; 4N0C; -. DR PDBsum; 4N5E; -. DR PDBsum; 4NHU; -. DR PDBsum; 5VCL; -. DR ProteinModelPortal; P01897; -. DR SMR; P01897; -. DR IntAct; P01897; 2. DR MINT; P01897; -. DR iPTMnet; P01897; -. DR PhosphoSitePlus; P01897; -. DR MaxQB; P01897; -. DR PeptideAtlas; P01897; -. DR PRIDE; P01897; -. DR MGI; MGI:95912; H2-L. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR InParanoid; P01897; -. DR EvolutionaryTrace; P01897; -. DR Proteomes; UP000000589; Unplaced. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006952; P:defense response; TAS:MGI. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Phosphoprotein; Reference proteome; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1 24 FT CHAIN 25 362 H-2 class I histocompatibility antigen, FT L-D alpha chain. FT /FTId=PRO_0000018932. FT TOPO_DOM 25 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 331 Helical. {ECO:0000255}. FT TOPO_DOM 332 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT MOD_RES 353 353 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 356 356 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT CARBOHYD 200 200 N-linked (GlcNAc...) asparagine. FT CARBOHYD 280 280 N-linked (GlcNAc...) asparagine. FT {ECO:0000305}. FT DISULFID 125 188 FT DISULFID 227 283 FT CONFLICT 17 24 LAPTQTRA -> WPDSDPR (in Ref. 2, 3 and 4). FT {ECO:0000305}. FT CONFLICT 35 35 Missing (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 145 145 C -> R (in Ref. 2, 3 and 4). FT {ECO:0000305}. FT CONFLICT 220 220 K -> E (in Ref. 5). {ECO:0000305}. FT CONFLICT 292 292 E -> H (in Ref. 4; CAA24129/AAA39661). FT {ECO:0000305}. FT CONFLICT 303 303 S -> F (in Ref. 5). {ECO:0000305}. FT STRAND 27 36 {ECO:0000244|PDB:4MS8}. FT STRAND 39 42 {ECO:0000244|PDB:3ERY}. FT STRAND 45 52 {ECO:0000244|PDB:4MS8}. FT STRAND 55 61 {ECO:0000244|PDB:4MS8}. FT STRAND 64 66 {ECO:0000244|PDB:4MS8}. FT STRAND 70 73 {ECO:0000244|PDB:4MS8}. FT TURN 74 76 {ECO:0000244|PDB:3V4U}. FT HELIX 81 107 {ECO:0000244|PDB:4MS8}. FT STRAND 113 115 {ECO:0000244|PDB:3ERY}. FT STRAND 118 127 {ECO:0000244|PDB:4MS8}. FT STRAND 129 131 {ECO:0000244|PDB:1LD9}. FT STRAND 133 142 {ECO:0000244|PDB:4MS8}. FT STRAND 145 150 {ECO:0000244|PDB:4MS8}. FT TURN 152 155 {ECO:0000244|PDB:1LD9}. FT STRAND 157 159 {ECO:0000244|PDB:4MS8}. FT HELIX 162 174 {ECO:0000244|PDB:4MS8}. FT HELIX 176 185 {ECO:0000244|PDB:4MS8}. FT HELIX 187 198 {ECO:0000244|PDB:4MS8}. FT HELIX 201 204 {ECO:0000244|PDB:1LD9}. FT STRAND 215 217 {ECO:0000244|PDB:1LD9}. FT TURN 219 221 {ECO:0000244|PDB:1LD9}. FT STRAND 223 228 {ECO:0000244|PDB:1LD9}. FT STRAND 231 235 {ECO:0000244|PDB:1LD9}. FT STRAND 238 247 {ECO:0000244|PDB:1LD9}. FT TURN 249 251 {ECO:0000244|PDB:1LDP}. FT STRAND 261 263 {ECO:0000244|PDB:1LD9}. FT STRAND 268 273 {ECO:0000244|PDB:1LD9}. FT TURN 275 277 {ECO:0000244|PDB:1LDP}. FT HELIX 278 280 {ECO:0000244|PDB:1LDP}. FT STRAND 282 286 {ECO:0000244|PDB:1LD9}. FT STRAND 288 290 {ECO:0000244|PDB:1LD9}. SQ SEQUENCE 362 AA; 40711 MW; A5EFDEE31177BF22 CRC64; MGAMAPRTLL LLLAAALAPT QTRAGPHSMR YFETAVSRPG LGEPRYISVG YVDNKEFVRF DSDAENPRYE PQAPWMEQEG PEYWERITQI AKGQEQWFRV NLRTLLGYYN QSAGGTHTLQ WMYGCDVGSD GRLLRGYEQF AYDGCDYIAL NEDLKTWTAA DMAAQITRRK WEQAGAAEYY RAYLEGECVE WLHRYLKNGN ATLLRTDSPK AHVTHHPRSK GEVTLRCWAL GFYPADITLT WQLNGEELTQ DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCRVYHEGL PEPLTLRWEP PPSTDSYMVI VAVLGVLGAM AIIGAVVAFV MKRRRNTGGK GGDYALAPGS QSSEMSLRDC KA // ID HA1Q_MOUSE Reviewed; 328 AA. AC P14428; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 20-JUN-2018, entry version 138. DE RecName: Full=H-2 class I histocompatibility antigen, K-Q alpha chain; DE Short=H-2K(Q); DE Flags: Fragment; GN Name=H2-K1; Synonyms=H2-K; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=3838967; DOI=10.1007/BF00430802; RA Morita T., Delarbre C., Kress M., Kourilsky P., Gachelin G.; RT "An H-2K gene of the tw32 mutant at the T/t complex is a close parent RT of an H-2Kq gene."; RL Immunogenetics 21:367-383(1985). RN [2] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-313, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=17242355; DOI=10.1073/pnas.0609836104; RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; RT "Large-scale phosphorylation analysis of mouse liver."; RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-313, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brown adipose tissue, Kidney, Lung, Pancreas, and Spleen; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M14827; AAA39656.1; -; mRNA. DR PIR; I54414; I54414. DR UniGene; Mm.422886; -. DR UniGene; Mm.439675; -. DR UniGene; Mm.440940; -. DR UniGene; Mm.441651; -. DR UniGene; Mm.466882; -. DR ProteinModelPortal; P14428; -. DR SMR; P14428; -. DR iPTMnet; P14428; -. DR MaxQB; P14428; -. DR PeptideAtlas; P14428; -. DR PRIDE; P14428; -. DR MGI; MGI:95904; H2-K1. DR HOVERGEN; HBG016709; -. DR ChiTaRS; H2-K1; mouse. DR Proteomes; UP000000589; Unplaced. DR CleanEx; MM_H2-K1; -. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; IDA:MGI. DR GO; GO:0042277; F:peptide binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0046977; F:TAP binding; ISO:MGI. DR GO; GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IDA:MGI. DR GO; GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; IDA:MGI. DR GO; GO:0042742; P:defense response to bacterium; IDA:MGI. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0048839; P:inner ear development; IDA:MGI. DR GO; GO:0010977; P:negative regulation of neuron projection development; IDA:MGI. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Transmembrane; KW Transmembrane helix. FT CHAIN <1 328 H-2 class I histocompatibility antigen, FT K-Q alpha chain. FT /FTId=PRO_0000080741. FT TOPO_DOM <1 265 Extracellular. {ECO:0000255}. FT TRANSMEM 266 289 Helical. {ECO:0000255}. FT TOPO_DOM 290 328 Cytoplasmic. {ECO:0000255}. FT DOMAIN 166 252 Ig-like C1-type. FT REGION <1 71 Alpha-1. FT REGION 72 163 Alpha-2. FT REGION 164 255 Alpha-3. FT REGION 256 265 Connecting peptide. FT MOD_RES 310 310 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 313 313 Phosphoserine. FT {ECO:0000244|PubMed:17242355, FT ECO:0000244|PubMed:21183079}. FT CARBOHYD 67 67 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 157 157 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 82 145 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 184 240 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT NON_TER 1 1 SQ SEQUENCE 328 AA; 36856 MW; ADFF1BD811BC37B4 CRC64; PRFISVGYVD DTELVRFDSD AENPRYEPRA RWMEQVEPEY WERNTQIAKD NEQSSRVDLR TLLRYYNQSA GGSHTIQRMY GCDVGSDGRL LRGYEQVAYD GCDYIALNED LKTWTAADMA ALITKHKWEQ AGAAERRRAY LEGACVEWLS RHLKNGNATL LRTDSPKAHV THHSRPEDKV TLRCWALGFY PADITLTWQL NGEELTQDME LVETRPAGDG TFQKWASVVV PLGKEQYYTC HVYHQGLPKP LTLRWEPPPS AVSNTVIIAV LVVLGAAIVT GAVVAFVMMR RRNTGGKGGD YALAPGSQTS DLSLPDCKVM VHDPHSLA // ID HA1T_MOUSE Reviewed; 384 AA. AC P14432; P14433; Q31194; Q31203; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 2. DT 23-MAY-2018, entry version 140. DE RecName: Full=H-2 class I histocompatibility antigen, TLA(B) alpha chain; DE AltName: Full=MHC thymus leukemia antigen; DE Flags: Precursor; GN Name=H2-T3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=BALB/cJ; RX PubMed=3894562; DOI=10.1084/jem.162.2.528; RA Fisher D.A., Hunt S.W. III, Hood L.E.; RT "Structure of a gene encoding a murine thymus leukemia antigen, and RT organization of Tla genes in the BALB/c mouse."; RL J. Exp. Med. 162:528-545(1985). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=3456611; DOI=10.1073/pnas.83.6.1782; RA Pontarotti P.A., Mashimo H., Zeff R.A., Fisher D.A., Hood L., RA Mellor A., Flavell R.A., Nathenson S.G.; RT "Conservation and diversity in the class I genes of the major RT histocompatibility complex: sequence analysis of a Tlab gene and RT comparison with a Tlac gene."; RL Proc. Natl. Acad. Sci. U.S.A. 83:1782-1786(1986). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=1339405; DOI=10.1007/BF00215662; RA Mashimo H., Chorney M.J., Pontarotti P., Fisher D.A., Hood L., RA Nathenson S.G.; RT "Nucleotide sequence of the BALB/c H-2T region gene, T3d."; RL Immunogenetics 36:326-332(1992). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-384. RX PubMed=2410925; DOI=10.1073/pnas.82.16.5475; RA Obata Y., Chen Y.-T., Stockert E., Old L.J.; RT "Structural analysis of TL genes of the mouse."; RL Proc. Natl. Acad. Sci. U.S.A. 82:5475-5479(1985). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- TISSUE SPECIFICITY: TL antigens are only expressed on thymocytes, CC activated T-lymphocytes and on some thymic leukemias. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=CAA26586.1; Type=Frameshift; Positions=359; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X02817; CAA26586.1; ALT_FRAME; Genomic_DNA. DR EMBL; M13285; AAA39687.1; -; Genomic_DNA. DR EMBL; M75875; AAA39658.1; -; Genomic_DNA. DR EMBL; M11741; AAA39692.1; -; Genomic_DNA. DR EMBL; M11742; AAA39692.1; JOINED; Genomic_DNA. DR CCDS; CCDS28718.1; -. DR PIR; A25132; A25132. DR PIR; A25148; A25148. DR PIR; I48851; I48851. DR PIR; I54499; I54499. DR UniGene; Mm.426002; -. DR PDB; 1NEZ; X-ray; 2.10 A; A=27-300. DR PDBsum; 1NEZ; -. DR ProteinModelPortal; P14432; -. DR SMR; P14432; -. DR STRING; 10090.ENSMUSP00000099736; -. DR MaxQB; P14432; -. DR PaxDb; P14432; -. DR PeptideAtlas; P14432; -. DR PRIDE; P14432; -. DR MGI; MGI:95959; H2-T3. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; P14432; -. DR PhylomeDB; P14432; -. DR EvolutionaryTrace; P14432; -. DR PRO; PR:P14432; -. DR Proteomes; UP000000589; Unplaced. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 26 {ECO:0000255}. FT CHAIN 27 384 H-2 class I histocompatibility antigen, FT TLA(B) alpha chain. FT /FTId=PRO_0000018937. FT TOPO_DOM 27 314 Extracellular. {ECO:0000255}. FT TRANSMEM 315 334 Helical. {ECO:0000255}. FT TOPO_DOM 335 384 Cytoplasmic. {ECO:0000255}. FT DOMAIN 211 299 Ig-like C1-type. FT REGION 27 116 Alpha-1. FT REGION 117 208 Alpha-2. FT REGION 209 300 Alpha-3. FT REGION 301 314 Connecting peptide. FT CARBOHYD 63 63 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 112 112 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 116 116 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 309 309 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 127 190 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 229 285 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 147 147 P -> R (in haplotype T3B). FT VARIANT 365 365 E -> D (in haplotype T3B). FT VARIANT 381 381 P -> H (in haplotype T3B). FT CONFLICT 6 6 P -> Q (in Ref. 1; CAA26586). FT {ECO:0000305}. FT CONFLICT 9 9 G -> S (in Ref. 1; CAA26586). FT {ECO:0000305}. FT CONFLICT 20 20 G -> V (in Ref. 1; CAA26586). FT {ECO:0000305}. FT CONFLICT 60 60 V -> A (in Ref. 1; CAA26586). FT {ECO:0000305}. FT CONFLICT 63 63 N -> D (in Ref. 1; CAA26586). FT {ECO:0000305}. FT CONFLICT 65 65 S -> A (in Ref. 1; CAA26586). FT {ECO:0000305}. FT CONFLICT 69 69 A -> G (in Ref. 1; CAA26586). FT {ECO:0000305}. FT CONFLICT 147 147 P -> Q (in Ref. 1; CAA26586). FT {ECO:0000305}. FT CONFLICT 164 164 T -> M (in Ref. 1; CAA26586). FT {ECO:0000305}. FT CONFLICT 219 219 P -> A (in Ref. 1; CAA26586). FT {ECO:0000305}. FT CONFLICT 224 224 Y -> D (in Ref. 1; CAA26586). FT {ECO:0000305}. FT CONFLICT 233 233 R -> G (in Ref. 1; CAA26586). FT {ECO:0000305}. FT CONFLICT 238 238 D -> H (in Ref. 1; CAA26586). FT {ECO:0000305}. FT CONFLICT 277 277 L -> S (in Ref. 1; CAA26586). FT {ECO:0000305}. FT CONFLICT 279 279 K -> E (in Ref. 1; CAA26586). FT {ECO:0000305}. FT CONFLICT 302 302 P -> L (in Ref. 4; AAA39692). FT {ECO:0000305}. FT CONFLICT 305 305 T -> S (in Ref. 1; CAA26586). FT {ECO:0000305}. FT CONFLICT 359 359 D -> T (in Ref. 4; AAA39692). FT {ECO:0000305}. FT STRAND 28 39 {ECO:0000244|PDB:1NEZ}. FT STRAND 48 54 {ECO:0000244|PDB:1NEZ}. FT STRAND 57 64 {ECO:0000244|PDB:1NEZ}. FT TURN 65 68 {ECO:0000244|PDB:1NEZ}. FT STRAND 70 73 {ECO:0000244|PDB:1NEZ}. FT HELIX 76 79 {ECO:0000244|PDB:1NEZ}. FT HELIX 83 102 {ECO:0000244|PDB:1NEZ}. FT HELIX 104 110 {ECO:0000244|PDB:1NEZ}. FT STRAND 115 117 {ECO:0000244|PDB:1NEZ}. FT STRAND 119 130 {ECO:0000244|PDB:1NEZ}. FT TURN 131 134 {ECO:0000244|PDB:1NEZ}. FT STRAND 135 144 {ECO:0000244|PDB:1NEZ}. FT STRAND 147 152 {ECO:0000244|PDB:1NEZ}. FT STRAND 159 163 {ECO:0000244|PDB:1NEZ}. FT HELIX 164 175 {ECO:0000244|PDB:1NEZ}. FT HELIX 178 187 {ECO:0000244|PDB:1NEZ}. FT HELIX 189 204 {ECO:0000244|PDB:1NEZ}. FT STRAND 212 219 {ECO:0000244|PDB:1NEZ}. FT STRAND 223 237 {ECO:0000244|PDB:1NEZ}. FT STRAND 240 245 {ECO:0000244|PDB:1NEZ}. FT STRAND 253 256 {ECO:0000244|PDB:1NEZ}. FT STRAND 263 265 {ECO:0000244|PDB:1NEZ}. FT STRAND 267 275 {ECO:0000244|PDB:1NEZ}. FT HELIX 280 282 {ECO:0000244|PDB:1NEZ}. FT STRAND 283 288 {ECO:0000244|PDB:1NEZ}. FT STRAND 292 294 {ECO:0000244|PDB:1NEZ}. FT STRAND 296 299 {ECO:0000244|PDB:1NEZ}. SQ SEQUENCE 384 AA; 43479 MW; 305891FC35F41E76 CRC64; MRMGTPVPGT LLILLAASQG QTQTCPGSHS LRYFYTALSR PAISEPWYIA VGYLDDTQFV RFNSSGETAT YKLSAPWVEQ EGPEYWARET EIVTSNAQFF RENLQTMLDY YNLSQNGSHT IQVMYGCEVE FFGSLFRAYE QHGYDGPDYI ALNEDLKTWT AADTAAEITR SKWEQAGYTE LRRTYLEGPC KDSLLRYLEN RKKTQECTDP PKTHVTHHPR PEGYVTLRCW ALRFYPADIT LTWQLNGEEL IQDTELVETR PAGDGTFQKW AAVVVPLGKE QKYTCHVYHE GLPEPLTLRW EPPQTSMPNR TTVRALLGAM IILGFMSGSV MMWMRKNNGG NGDDNTAAYQ NEREHLSLDP RAESEALGVE AGMKDLPSAP PLVS // ID HA1W_MOUSE Reviewed; 368 AA. AC P03991; P03990; DT 23-OCT-1986, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 2. DT 20-JUN-2018, entry version 145. DE RecName: Full=H-2 class I histocompatibility antigen, K-W28 alpha chain; DE Flags: Precursor; GN Name=H2-K1; Synonyms=H2-K; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=3838967; DOI=10.1007/BF00430802; RA Morita T., Delarbre C., Kress M., Kourilsky P., Gachelin G.; RT "An H-2K gene of the tw32 mutant at the T/t complex is a close parent RT of an H-2Kq gene."; RL Immunogenetics 21:367-383(1985). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 258-368. RC STRAIN=SWR; RX PubMed=6689056; DOI=10.1038/306602a0; RA Kress M., Glaros D., Khoury G., Jay G.; RT "Alternative RNA splicing in expression of the H-2K gene."; RL Nature 306:602-604(1983). RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-353, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=17242355; DOI=10.1073/pnas.0609836104; RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; RT "Large-scale phosphorylation analysis of mouse liver."; RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). RN [4] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-353, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brown adipose tissue, Kidney, Lung, Pancreas, and Spleen; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M14825; AAA39657.1; -; Genomic_DNA. DR EMBL; X00172; CAA24997.1; -; mRNA. DR PIR; A02197; A02197. DR PIR; I68705; I68705. DR UniGene; Mm.422886; -. DR UniGene; Mm.439675; -. DR UniGene; Mm.440940; -. DR UniGene; Mm.441651; -. DR UniGene; Mm.466882; -. DR ProteinModelPortal; P03991; -. DR SMR; P03991; -. DR iPTMnet; P03991; -. DR PhosphoSitePlus; P03991; -. DR MaxQB; P03991; -. DR PeptideAtlas; P03991; -. DR PRIDE; P03991; -. DR MGI; MGI:95904; H2-K1. DR HOVERGEN; HBG016709; -. DR ChiTaRS; H2-K1; mouse. DR Proteomes; UP000000589; Unplaced. DR CleanEx; MM_H2-K1; -. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; IDA:MGI. DR GO; GO:0042277; F:peptide binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0046977; F:TAP binding; ISO:MGI. DR GO; GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IDA:MGI. DR GO; GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; IDA:MGI. DR GO; GO:0042742; P:defense response to bacterium; IDA:MGI. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0048839; P:inner ear development; IDA:MGI. DR GO; GO:0010977; P:negative regulation of neuron projection development; IDA:MGI. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 21 {ECO:0000250}. FT CHAIN 22 368 H-2 class I histocompatibility antigen, FT K-W28 alpha chain. FT /FTId=PRO_0000018931. FT TOPO_DOM 22 305 Extracellular. {ECO:0000255}. FT TRANSMEM 306 329 Helical. {ECO:0000255}. FT TOPO_DOM 330 368 Cytoplasmic. {ECO:0000255}. FT DOMAIN 206 292 Ig-like C1-type. FT REGION 22 111 Alpha-1. FT REGION 112 203 Alpha-2. FT REGION 204 295 Alpha-3. FT REGION 296 305 Connecting peptide. FT MOD_RES 350 350 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT MOD_RES 353 353 Phosphoserine. FT {ECO:0000244|PubMed:17242355, FT ECO:0000244|PubMed:21183079}. FT CARBOHYD 107 107 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 197 197 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 122 185 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 224 280 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 368 AA; 41104 MW; C07A9CDC458BA58F CRC64; MAPCMLLLLL AAALAPTQTR AGPHSLRYFH TAVSRPGLGK PRFISVGYVD DTEFVRFDSD AENPRYEPRA RWMEQVEPEY WERNTQIAKD NEQSSRVDLR TLLRYYNQSA GGSHTIQRMY GCDVGSDGRL LRGYEQVAYD GCDYIALNED LKTWTAADMA ALITKHKWEQ AGAAERRRAY LEGACVEWLS RHLKNGNATL LRTDSPKAHV THHSRPEDKV TLRCWALGFY PADITLTWQL NGEELTQDME LVETRPAGDG TFQKWASVVV PLGKEQYYTC HVYHQGLPKP LTLRWEPPPS AVSNTVIIAV LVVLGAAIVT GAVVAFVMMR RRNTGGKGGD YALAPGSQTS DLSLPDCKVM VHDPHSLA // ID HA1Y_MOUSE Reviewed; 298 AA. AC P01895; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 20-JUN-2018, entry version 140. DE RecName: Full=H-2 class I histocompatibility antigen, alpha chain; DE AltName: Full=Clone PAG64; DE Flags: Fragment; GN Name=H2-D1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-285 (CLONE PAG64). RX PubMed=6318117; DOI=10.1038/306756a0; RA Brickell P.M., Latchman D.S., Murphy D., Willison K., Rigby P.W.J.; RT "Activation of a Qa/Tla class I major histocompatibility antigen gene RT is a general feature of oncogenesis in the mouse."; RL Nature 306:756-760(1983). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 90-298 (CLONE PH-2D-1). RX PubMed=6895103; DOI=10.1038/292078a0; RA Bregegere F., Abastado J.P., Kvist S., Rask L., Lalanne J.-L., RA Garoff H., Cami B., Wiman K.G., Larhammar D., Peterson P.A., RA Gachelin G., Kourilsky P., Dobberstein B.; RT "Structure of C-terminal half of two H-2 antigens from cloned mRNA."; RL Nature 292:78-81(1981). RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289 AND SER-292, VARIANT RP [LARGE SCALE ANALYSIS] GLY-285, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006; RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M., RA Thibault P.; RT "The phagosomal proteome in interferon-gamma-activated macrophages."; RL Immunity 30:143-154(2009). RN [4] RP VARIANT [LARGE SCALE ANALYSIS] GLY-285, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Lung, and Spleen; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=P01895-1; Sequence=Displayed; CC Name=2; CC IsoId=P01895-2; Sequence=VSP_003228; CC Note=Exon 7 is missing.; CC -!- MISCELLANEOUS: The antigen encoded by the PAG64 clone, normally CC expressed only on lymphocyte subsets and thymocytes, is found in CC increased concentrations in all transformed cells tested, in an CC embryonic carcinoma cell line, and in pluripotent embryonic cells. CC Activation of the gene appears to be a general feature of CC carcinogenesis in the mouse. The PAG64 clone, and related cDNA CC clones, have in common a repetitive sequence in their 3' CC transcription units that has characteristics of a transposable CC element. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X00246; CAA25061.1; -; mRNA. DR PIR; A93322; HLMS1. DR UniGene; Mm.439675; -. DR ProteinModelPortal; P01895; -. DR SMR; P01895; -. DR iPTMnet; P01895; -. DR MaxQB; P01895; -. DR PeptideAtlas; P01895; -. DR PRIDE; P01895; -. DR MGI; MGI:95896; H2-D1. DR HOVERGEN; HBG016709; -. DR ChiTaRS; H2-D1; mouse. DR Proteomes; UP000000589; Unplaced. DR CleanEx; MM_H2-D1; -. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IDA:MGI. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; ISO:MGI. DR GO; GO:0042277; F:peptide binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0046977; F:TAP binding; ISO:MGI. DR GO; GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IDA:MGI. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0010977; P:negative regulation of neuron projection development; IDA:MGI. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Phosphoprotein; Reference proteome; KW Transmembrane; Transmembrane helix. FT CHAIN <1 298 H-2 class I histocompatibility antigen, FT alpha chain. FT /FTId=PRO_0000080742. FT TOPO_DOM <1 244 Extracellular. {ECO:0000255}. FT TRANSMEM 245 265 Helical. {ECO:0000255}. FT TOPO_DOM 266 298 Cytoplasmic. {ECO:0000255}. FT DOMAIN 142 230 Ig-like C1-type. FT MOD_RES 289 289 Phosphoserine. FT {ECO:0000244|PubMed:19144319}. FT MOD_RES 292 292 Phosphoserine. FT {ECO:0000244|PubMed:19144319}. FT CARBOHYD 43 43 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT CARBOHYD 133 133 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 58 121 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 160 216 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VAR_SEQ 286 298 Missing (in isoform 2). {ECO:0000305}. FT /FTId=VSP_003228. FT VARIANT 212 212 Q -> L (in clone PH-2D-1). FT VARIANT 223 223 Missing (in clone PH-2D-1). FT VARIANT 285 285 V -> G (in clone PH-2D-1). FT {ECO:0000244|PubMed:19144319, FT ECO:0000244|PubMed:21183079}. FT NON_TER 1 1 SQ SEQUENCE 298 AA; 33850 MW; 7F9CE29A053B06FB CRC64; RYEPRARWIE QEGPEYWERE TRRAKGNEQS FRVDLRTALR YYNQSAGGSH TLQWMAGCDV ESDGRLLRGY WQFAYDGCDY IALNEDLKTW TAADMAAQIT RRKWEQAGAA ERDRAYLEGE CVEWLRRYLK NGNATLLRTD PPKAHVTHHR RPEGDVTLRC WALGFYPADI TLTWQLNGEE LTQEMELVET RPAGDGTFQK WASVVVPLGK EQKYTCHVEH EGLPEPLTLR WGKEEPPSST KTNTVIIAVP VVLGAVVILG AVMAFVMKRR RNTGGKGGDY ALAPVSQSSD MSLPDCKV // ID HFE_HUMAN Reviewed; 348 AA. AC Q30201; B2CKL0; O75929; O75930; O75931; Q17RT0; Q96KU5; Q96KU6; AC Q96KU7; Q96KU8; Q9HC64; Q9HC68; Q9HC70; Q9HC83; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 12-SEP-2018, entry version 198. DE RecName: Full=Hereditary hemochromatosis protein; DE AltName: Full=HLA-H; DE Flags: Precursor; GN Name=HFE; Synonyms=HLAH; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT HFE1 TYR-282, AND RP VARIANT ASP-63. RX PubMed=8696333; DOI=10.1038/ng0896-399; RA Feder J.N., Gnirke A., Thomas W., Tsuchihashi Z., Ruddy D.A., RA Basava A., Dormishian F., Domingo R. Jr., Ellis M.C. Jr., Fullan A., RA Hinton L.M., Jones N.L., Kimmel B.E., Kronmal G.S., Lauer P., RA Lee V.K., Loeb D.B., Mapa F.A., McClelland E., Meyer N.C., RA Mintier G.A., Moeller N., Moore T., Morikang E., Prass C.E., RA Quintana L., Starnes S.M., Schatzman R.C., Brunke K.J., Drayna D.T., RA Risch N.J., Bacon B.R., Wolff R.K.; RT "A novel MHC class I-like gene is mutated in patients with hereditary RT haemochromatosis."; RL Nat. Genet. 13:399-409(1996). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1). RX PubMed=9149941; RA Ruddy D.A., Kronmal G.S., Lee V.K., Mintier G.A., Quintana L., RA Domingo R. Jr., Meyer N.C., Irrinki A., McClelland E.E., Fullan A., RA Mapa F.A., Moore T., Thomas W., Loeb D.B., Harmon C., Tsuchihashi Z., RA Wolff R.K., Schatzman R.C., Feder J.N.; RT "A 1.1-Mb transcript map of the hereditary hemochromatosis locus."; RL Genome Res. 7:441-456(1997). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). RX PubMed=9548560; RX DOI=10.1002/(SICI)1097-4644(19980501)69:2<117::AID-JCB3>3.0.CO;2-V; RA Albig W., Drabent B., Burmester N., Bode C., Doenecke D.; RT "The haemochromatosis candidate gene HFE (HLA-H) of man and mouse is RT located in syntenic regions within the histone gene."; RL J. Cell. Biochem. 69:117-126(1998). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). RA Gasparini P.; RT "Hereditary hemochromatosis genomic structure and organization of HLA- RT H gene."; RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4). RX PubMed=10079302; DOI=10.1007/s002510050505; RA Rhodes D.A., Trowsdale J.; RT "Alternate splice variants of the hemochromatosis gene Hfe."; RL Immunogenetics 49:357-359(1999). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 7; 8; 9 AND 10). RX PubMed=11001625; DOI=10.1006/bcmd.2000.0291; RA Thenie A., Orhant M., Gicquel I., Fergelot P., Le Gall J.-Y., RA David V., Mosser J.; RT "The HFE gene undergoes alternate splicing processes."; RL Blood Cells Mol. Dis. 26:155-162(2000). RN [7] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 5; 6; 7 AND 11). RX PubMed=11358357; DOI=10.1006/bcmd.2000.0346; RA Sanchez M., Bruguera M., Rodos J., Oliva R.; RT "Complete characterization of the 3' region of the human and mouse RT hereditary hemochromatosis HFE gene and detection of novel splicing RT forms."; RL Blood Cells Mol. Dis. 27:35-43(2001). RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS MET-53; ASP-63; RP GLN-224 AND TYR-282. RG NIEHS SNPs program; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Colon; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [11] RP FUNCTION, AND SUBCELLULAR LOCATION. RX PubMed=9465039; DOI=10.1073/pnas.95.4.1472; RA Feder J.N., Penny D.M., Irrinki A., Lee V.K., Lebron J.A., Watson N., RA Tsuchihashi Z., Sigal E., Bjorkman P.J., Schatzman R.C.; RT "The hemochromatosis gene product complexes with the transferrin RT receptor and lowers its affinity for ligand binding."; RL Proc. Natl. Acad. Sci. U.S.A. 95:1472-1477(1998). RN [12] RP INVOLVEMENT IN TFQTL2. RX PubMed=19084217; DOI=10.1016/j.ajhg.2008.11.011; RA Benyamin B., McRae A.F., Zhu G., Gordon S., Henders A.K., Palotie A., RA Peltonen L., Martin N.G., Montgomery G.W., Whitfield J.B., RA Visscher P.M.; RT "Variants in TF and HFE explain approximately 40% of genetic variation RT in serum-transferrin levels."; RL Am. J. Hum. Genet. 84:60-65(2009). RN [13] RP X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 23-297 IN COMPLEX WITH TFR. RX PubMed=9546397; DOI=10.1016/S0092-8674(00)81151-4; RA Lebron J.A., Bennett M.J., Vaughn D.E., Chirino A.J., Snow P.M., RA Mintier G.A., Feder J.N., Bjorkman P.J.; RT "Crystal structure of the hemochromatosis protein HFE and RT characterization of its interaction with transferrin receptor."; RL Cell 93:111-123(1998). RN [14] RP 3D-STRUCTURE MODELING OF 26-293 IN COMPLEX WITH B2MG. RX PubMed=11018711; DOI=10.1016/S0167-4838(00)00126-6; RA Dupradeau F., Altenberg-Greulich B., Warin R., Fuentes V., Monti J., RA Rochette J.; RT "A 3-dimensional model building by homology of the HFE protein: RT molecular consequences and application to antibody development."; RL Biochim. Biophys. Acta 1481:213-221(2000). RN [15] RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 26-297 IN COMPLEX WITH TFR. RX PubMed=10638746; DOI=10.1038/47417; RA Bennett M.J., Lebron J.A., Bjorkman P.J.; RT "Crystal structure of the hereditary haemochromatosis protein HFE RT complexed with transferrin receptor."; RL Nature 403:46-53(2000). RN [16] RP SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S). RX PubMed=14759258; DOI=10.1186/gb-2004-5-2-r8; RA Hillman R.T., Green R.E., Brenner S.E.; RT "An unappreciated role for RNA surveillance."; RL Genome Biol. 5:R8.1-R8.16(2004). RN [17] RP VARIANT HFE1 TYR-282, AND VARIANT ASP-63. RX PubMed=9106528; RA Carella M., D'Ambrosio L., Totaro A., Grifa A., Valentino M.A., RA Piperno A., Girelli D., Roetto A., Franco B., Gasparini P., RA Camaschella C.; RT "Mutation analysis of the HLA-H gene in Italian hemochromatosis RT patients."; RL Am. J. Hum. Genet. 60:828-832(1997). RN [18] RP VARIANT HFE1 TYR-282, AND ASSOCIATION WITH PORPHYRIA CUTANEA TARDA. RX PubMed=9024376; DOI=10.1016/S0140-6736(96)09436-6; RA Roberts A.G., Whatley S.D., Morgan R.R., Worwood M., Elder G.H.; RT "Increased frequency of the haemochromatosis Cys282Tyr mutation in RT sporadic porphyria cutanea tarda."; RL Lancet 349:321-323(1997). RN [19] RP VARIANT ASP-63. RX PubMed=9425935; DOI=10.1002/hep.510270128; RA Sampietro M., Piperno A., Lupica L., Arosio C., Vergani A., RA Corbetta N., Malosio I., Mattioli M., Fracanzani A.L., RA Cappellini M.D., Fiorelli G., Fargion S.; RT "High prevalence of the His63Asp HFE mutation in Italian patients with RT porphyria cutanea tarda."; RL Hepatology 27:181-184(1998). RN [20] RP VARIANT HFE1 TYR-282, AND VARIANT ASP-63. RX PubMed=9620340; DOI=10.1002/hep.510270627; RA Bonkovsky H.L., Poh-Fitzpatrick M., Pimstone N., Obando J., RA Di Bisceglie A., Tattrie C., Tortorelli K., LeClair P., Mercurio M.G., RA Lambrecht R.W.; RT "Porphyria cutanea tarda, hepatitis C, and HFE gene mutations in North RT America."; RL Hepatology 27:1661-1669(1998). RN [21] RP VARIANTS HFE1 CYS-65 AND TYR-282, AND VARIANT ASP-63. RX PubMed=10194428; RA Mura C., Raguenes O., Ferec C.; RT "HFE mutations analysis in 711 hemochromatosis probands: evidence for RT S65C implication in mild form of hemochromatosis."; RL Blood 93:2502-2505(1999). RN [22] RP VARIANTS HFE1 CYS-65; ARG-93 AND THR-105. RX PubMed=10575540; DOI=10.1006/bcmd.1999.0240; RA Barton J.C., Sawada-Hirai R., Rothenberg B.E., Acton R.T.; RT "Two novel missense mutations of the HFE gene (I105T and G93R) and RT identification of the S65C mutation in Alabama hemochromatosis RT probands."; RL Blood Cells Mol. Dis. 25:147-155(1999). RN [23] RP VARIANTS HFE1 HIS-127 AND MET-330, AND VARIANTS MET-53; MET-59 AND RP ASP-63. RX PubMed=10401000; DOI=10.1093/hmg/8.8.1517; RA de Villiers J.N.P., Hillermann R., Loubser L., Kotze M.J.; RT "Spectrum of mutations in the HFE gene implicated in haemochromatosis RT and porphyria."; RL Hum. Mol. Genet. 8:1517-1522(1999). RN [24] RP VARIANT HFE1 TYR-282, AND VARIANT ASP-63. RX PubMed=10094552; RX DOI=10.1002/(SICI)1098-1004(1999)13:2<154::AID-HUMU8>3.0.CO;2-E; RA Merryweather-Clarke A.T., Simonsen H., Shearman J.D., Pointon J.J., RA Norgaard-Pedersen B., Robson K.J.H.; RT "A retrospective anonymous pilot study in screening newborns for HFE RT mutations in Scandinavian populations."; RL Hum. Mutat. 13:154-159(1999). RN [25] RP VARIANT HFE1 CYS-65. RA Fagan E., Payne S.J.; RT "A novel missense mutation S65C in the HFE gene with a possible role RT in hereditary haemochromatosis."; RL Hum. Mutat. 13:507-508(1999). RN [26] RP VARIANT LYS-277. RX PubMed=10612845; RX DOI=10.1002/(SICI)1098-1004(200001)15:1<120::AID-HUMU32>3.0.CO;2-B; RA Bradbury R., Fagan E., Payne S.J.; RT "Two novel polymorphisms (E277K and V212V) in the haemochromatosis RT gene HFE."; RL Hum. Mutat. 15:120-120(2000). RN [27] RP VARIANTS ASP-63 AND TYR-282. RX PubMed=11069625; DOI=10.1046/j.1523-1747.2000.00148.x; RA Brady J.J., Jackson H.A., Roberts A.G., Morgan R.R., Whatley S.D., RA Rowlands G.L., Darby C., Shudell E., Watson R., Paiker J., RA Worwood M.W., Elder G.H.; RT "Co-inheritance of mutations in the uroporphyrinogen decarboxylase and RT hemochromatosis genes accelerates the onset of porphyria cutanea RT tarda."; RL J. Invest. Dermatol. 115:868-874(2000). RN [28] RP VARIANT HFE1 TYR-282, VARIANT ASP-63, AND ASSOCIATION WITH DIABETIC RP NEPHROPATHY SUSCEPTIBILITY. RX PubMed=11423500; DOI=10.2337/diacare.24.7.1187; RA Moczulski D.K., Grzeszczak W., Gawlik B.; RT "Role of hemochromatosis C282Y and H63D mutations in HFE gene in RT development of type 2 diabetes and diabetic nephropathy."; RL Diabetes Care 24:1187-1191(2001). RN [29] RP VARIANT HFE1 VAL-176. RX PubMed=11446670; RA Imanishi H., Liu W., Cheng J., Ikeda N., Amuro Y., Hada T.; RT "Idiopathic hemochromatosis with the mutation of Ala176Val RT heterozygous for HFE gene."; RL Intern. Med. 40:479-483(2001). RN [30] RP VARIANTS HFE1 CYS-65; TYR-282 AND ALA-295. RX PubMed=12542741; DOI=10.1034/j.1399-0039.2002.600603.x; RA Jones D.C., Young N.T., Pigott C., Fuggle S.V., Barnardo M.C.N.M., RA Marshall S.E., Bunce M.; RT "Comprehensive hereditary hemochromatosis genotyping."; RL Tissue Antigens 60:481-488(2002). RN [31] RP VARIANT HFE1 PRO-283, AND CHARACTERIZATION OF VARIANT HFE1 PRO-283. RX PubMed=12737937; DOI=10.1016/S1079-9796(03)00036-6; RA Le Gac G., Dupradeau F.-Y., Mura C., Jacolot S., Scotet V., RA Esnault G., Mercier A.-Y., Rochette J., Ferec C.; RT "Phenotypic expression of the C282Y/Q283P compound heterozygosity in RT HFE and molecular modeling of the Q283P mutation effect."; RL Blood Cells Mol. Dis. 30:231-237(2003). RN [32] RP VARIANTS HFE1 CYS-65; CYS-66; GLY-224 AND TYR-282. RX PubMed=14633868; DOI=10.1373/clinchem.2003.023440; RA Biasiotto G., Belloli S., Ruggeri G., Zanella I., Gerardi G., RA Corrado M., Gobbi E., Albertini A., Arosio P.; RT "Identification of new mutations of the HFE, hepcidin, and transferrin RT receptor 2 genes by denaturing HPLC analysis of individuals with RT biochemical indications of iron overload."; RL Clin. Chem. 49:1981-1988(2003). RN [33] RP VARIANT HFE1 SER-6. RX PubMed=12584229; DOI=10.1136/gut.52.3.433; RA Wigg A.J., Harley H., Casey G.; RT "Heterozygous recipient and donor HFE mutations associated with a RT hereditary haemochromatosis phenotype after liver transplantation."; RL Gut 52:433-435(2003). RN [34] RP VARIANT HFE1 ALA-295. RX PubMed=15046077; RA Bento M.C., Ribeiro M.L., Relvas L.; RT "Gene symbol: HFE. Disease: haemochromatosis."; RL Hum. Genet. 114:405-405(2004). RN [35] RP CHARACTERIZATION OF VARIANT HFE1 PRO-283. RX PubMed=15965644; DOI=10.1007/s00439-005-1307-y; RA Ka C., Le Gac G., Dupradeau F.-Y., Rochette J., Ferec C.; RT "The Q283P amino-acid change in HFE leads to structural and functional RT consequences similar to those described for the mutated 282Y HFE RT protein."; RL Hum. Genet. 117:467-475(2005). RN [36] RP VARIANTS HFE1 ASP-43 AND TYR-282, AND VARIANT ASP-63. RX PubMed=18157833; DOI=10.1002/humu.9517; RA Dupradeau F.-Y., Pissard S., Coulhon M.-P., Cadet E., Foulon K., RA Fourcade C., Goossens M., Case D.A., Rochette J.; RT "An unusual case of hemochromatosis due to a new compound RT heterozygosity in HFE (p.[Gly43Asp;His63Asp]+[Cys282Tyr]): structural RT implications with respect to binding with transferrin receptor 1."; RL Hum. Mutat. 29:206-206(2008). CC -!- FUNCTION: Binds to transferrin receptor (TFR) and reduces its CC affinity for iron-loaded transferrin. CC {ECO:0000269|PubMed:9465039}. CC -!- SUBUNIT: Binds TFR through the extracellular domain in a pH- CC dependent manner. {ECO:0000269|PubMed:10638746, CC ECO:0000269|PubMed:9546397}. CC -!- INTERACTION: CC P61769:B2M; NbExp=4; IntAct=EBI-1028850, EBI-714718; CC P02786:TFRC; NbExp=3; IntAct=EBI-1028850, EBI-355727; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9465039}; CC Single-pass type I membrane protein {ECO:0000305|PubMed:8696333}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=11; CC Comment=Additional isoforms seem to exist.; CC Name=1; CC IsoId=Q30201-1; Sequence=Displayed; CC Note=May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay.; CC Name=2; Synonyms=delE2; CC IsoId=Q30201-2; Sequence=VSP_003218; CC Name=3; Synonyms=del14E4; CC IsoId=Q30201-3; Sequence=VSP_003225; CC Name=4; Synonyms=delE214E4; CC IsoId=Q30201-4; Sequence=VSP_003218, VSP_003225; CC Name=5; CC IsoId=Q30201-5; Sequence=VSP_003219; CC Name=6; CC IsoId=Q30201-6; Sequence=VSP_047336, VSP_003220; CC Name=7; Synonyms=delE3; CC IsoId=Q30201-7; Sequence=VSP_003221; CC Name=8; Synonyms=1043-2283del,intron6ins; CC IsoId=Q30201-8; Sequence=VSP_003226, VSP_003227; CC Name=9; Synonyms=delE3-7; CC IsoId=Q30201-9; Sequence=VSP_003223, VSP_003224; CC Name=10; Synonyms=562-878del; CC IsoId=Q30201-10; Sequence=VSP_003222; CC Name=11; CC IsoId=Q30201-11; Sequence=VSP_043477, VSP_043478; CC Note=No experimental confirmation available.; CC -!- TISSUE SPECIFICITY: Expressed in all tissues tested except brain. CC -!- POLYMORPHISM: Genetic variations in HFE define the transferrin CC serum level quantitative trait locus 2 (TFQTL2) [MIM:614193]. Iron CC is essential for biochemical functions such as oxygen transport CC and oxidative phosphorylation. Excessive iron can cause iron- CC overload-related liver diseases, whereas iron deficiency can lead CC to anemia. Iron status can be assessed by measuring the levels of CC serum iron, serum transferrin, transferrin saturation with iron, CC and serum ferritin. CC -!- DISEASE: Hemochromatosis 1 (HFE1) [MIM:235200]: A disorder of iron CC metabolism characterized by iron overload. Excess iron is CC deposited in a variety of organs leading to their failure, and CC resulting in serious illnesses including cirrhosis, hepatomas, CC diabetes, cardiomyopathy, arthritis, and hypogonadotropic CC hypogonadism. Severe effects of the disease usually do not appear CC until after decades of progressive iron loading. CC {ECO:0000269|PubMed:10094552, ECO:0000269|PubMed:10194428, CC ECO:0000269|PubMed:10401000, ECO:0000269|PubMed:10575540, CC ECO:0000269|PubMed:11423500, ECO:0000269|PubMed:11446670, CC ECO:0000269|PubMed:12542741, ECO:0000269|PubMed:12584229, CC ECO:0000269|PubMed:12737937, ECO:0000269|PubMed:14633868, CC ECO:0000269|PubMed:15046077, ECO:0000269|PubMed:15965644, CC ECO:0000269|PubMed:18157833, ECO:0000269|PubMed:8696333, CC ECO:0000269|PubMed:9024376, ECO:0000269|PubMed:9106528, CC ECO:0000269|PubMed:9620340, ECO:0000269|Ref.25}. Note=The disease CC is caused by mutations affecting the gene represented in this CC entry. CC -!- DISEASE: Variegate porphyria (VP) [MIM:176200]: A form of CC porphyria. Porphyrias are inherited defects in the biosynthesis of CC heme, resulting in the accumulation and increased excretion of CC porphyrins or porphyrin precursors. They are classified as CC erythropoietic or hepatic, depending on whether the enzyme CC deficiency occurs in red blood cells or in the liver. Variegate CC porphyria is the most common form of porphyria in South Africa. It CC is characterized by skin hyperpigmentation and hypertrichosis, CC abdominal pain, tachycardia, hypertension and neuromuscular CC disturbances. High fecal levels of protoporphyrin and CC coproporphyrin, increased urine uroporphyrins and iron overload CC are typical markers of the disease. Note=Disease susceptibility is CC associated with variations affecting the gene represented in this CC entry. Iron overload due to HFE variants is a precipitating or CC exacerbating factor in variegate porphyria. CC -!- DISEASE: Microvascular complications of diabetes 7 (MVCD7) CC [MIM:612635]: Pathological conditions that develop in numerous CC tissues and organs as a consequence of diabetes mellitus. They CC include diabetic retinopathy, diabetic nephropathy leading to end- CC stage renal disease, and diabetic neuropathy. Diabetic retinopathy CC remains the major cause of new-onset blindness among diabetic CC adults. It is characterized by vascular permeability and increased CC tissue ischemia and angiogenesis. Note=Disease susceptibility is CC associated with variations affecting the gene represented in this CC entry. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology CC and Haematology; CC URL="http://atlasgeneticsoncology.org/Genes/HFEID44099ch6p22.html"; CC -!- WEB RESOURCE: Name=NIEHS-SNPs; CC URL="http://egp.gs.washington.edu/data/hfe/"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; U60319; AAC51823.1; -; mRNA. DR EMBL; U91328; AAB82083.1; -; Genomic_DNA. DR EMBL; Z92910; CAB07442.1; -; Genomic_DNA. DR EMBL; Y09801; CAA70934.1; -; Genomic_DNA. DR EMBL; Y09800; CAA70934.1; JOINED; Genomic_DNA. DR EMBL; Y09803; CAA70934.1; JOINED; Genomic_DNA. DR EMBL; Y09799; CAA70934.1; JOINED; Genomic_DNA. DR EMBL; AF079407; AAC62646.1; -; mRNA. DR EMBL; AF079408; AAC62647.1; -; mRNA. DR EMBL; AF079409; AAC62648.1; -; mRNA. DR EMBL; AF115264; AAG29571.1; -; mRNA. DR EMBL; AF115265; AAG29572.1; -; mRNA. DR EMBL; AF144240; AAG29575.1; -; mRNA. DR EMBL; AF144242; AAG29577.1; -; mRNA. DR EMBL; AF149804; AAG29342.1; -; mRNA. DR EMBL; AJ249335; CAC67792.1; -; mRNA. DR EMBL; AJ249336; CAC67793.1; -; mRNA. DR EMBL; AJ249337; CAC67794.1; -; mRNA. DR EMBL; AJ249338; CAC67795.1; -; mRNA. DR EMBL; AJ250635; CAC80805.1; -; mRNA. DR EMBL; EU523119; ACB21042.1; -; Genomic_DNA. DR EMBL; CH471087; EAW55524.1; -; Genomic_DNA. DR EMBL; CH471087; EAW55526.1; -; Genomic_DNA. DR EMBL; BC117201; AAI17202.1; -; mRNA. DR EMBL; BC117203; AAI17204.1; -; mRNA. DR CCDS; CCDS4578.1; -. [Q30201-1] DR CCDS; CCDS4579.1; -. [Q30201-7] DR CCDS; CCDS4580.1; -. [Q30201-2] DR CCDS; CCDS4581.1; -. [Q30201-6] DR CCDS; CCDS4582.1; -. [Q30201-11] DR CCDS; CCDS47386.1; -. [Q30201-10] DR CCDS; CCDS47387.1; -. [Q30201-5] DR CCDS; CCDS54974.1; -. [Q30201-3] DR CCDS; CCDS54975.1; -. [Q30201-4] DR RefSeq; NP_000401.1; NM_000410.3. [Q30201-1] DR RefSeq; NP_001287678.1; NM_001300749.1. DR RefSeq; NP_620572.1; NM_139003.2. [Q30201-10] DR RefSeq; NP_620573.1; NM_139004.2. [Q30201-7] DR RefSeq; NP_620575.1; NM_139006.2. [Q30201-3] DR RefSeq; NP_620576.1; NM_139007.2. [Q30201-2] DR RefSeq; NP_620577.1; NM_139008.2. [Q30201-4] DR RefSeq; NP_620578.1; NM_139009.2. [Q30201-5] DR RefSeq; NP_620579.1; NM_139010.2. [Q30201-6] DR RefSeq; NP_620580.1; NM_139011.2. [Q30201-11] DR UniGene; Hs.233325; -. DR PDB; 1A6Z; X-ray; 2.60 A; A/C=23-297. DR PDB; 1C42; Model; -; A=26-293. DR PDB; 1DE4; X-ray; 2.80 A; A/D/G=23-297. DR PDBsum; 1A6Z; -. DR PDBsum; 1C42; -. DR PDBsum; 1DE4; -. DR ProteinModelPortal; Q30201; -. DR SMR; Q30201; -. DR BioGrid; 109325; 95. DR DIP; DIP-2737N; -. DR IntAct; Q30201; 8. DR MINT; Q30201; -. DR STRING; 9606.ENSP00000417404; -. DR iPTMnet; Q30201; -. DR PhosphoSitePlus; Q30201; -. DR BioMuta; HFE; -. DR DMDM; 2497915; -. DR MaxQB; Q30201; -. DR PaxDb; Q30201; -. DR PeptideAtlas; Q30201; -. DR PRIDE; Q30201; -. DR ProteomicsDB; 61558; -. DR ProteomicsDB; 61559; -. [Q30201-10] DR ProteomicsDB; 61560; -. [Q30201-11] DR ProteomicsDB; 61561; -. [Q30201-2] DR ProteomicsDB; 61562; -. [Q30201-3] DR ProteomicsDB; 61563; -. [Q30201-4] DR ProteomicsDB; 61564; -. [Q30201-5] DR ProteomicsDB; 61565; -. [Q30201-6] DR ProteomicsDB; 61566; -. [Q30201-7] DR ProteomicsDB; 61567; -. [Q30201-8] DR ProteomicsDB; 61568; -. [Q30201-9] DR TopDownProteomics; Q30201-1; -. [Q30201-1] DR DNASU; 3077; -. DR Ensembl; ENST00000317896; ENSP00000313776; ENSG00000010704. [Q30201-7] DR Ensembl; ENST00000336625; ENSP00000337819; ENSG00000010704. [Q30201-10] DR Ensembl; ENST00000349999; ENSP00000259699; ENSG00000010704. [Q30201-2] DR Ensembl; ENST00000352392; ENSP00000315936; ENSG00000010704. [Q30201-11] DR Ensembl; ENST00000353147; ENSP00000312342; ENSG00000010704. [Q30201-6] DR Ensembl; ENST00000357618; ENSP00000417404; ENSG00000010704. [Q30201-1] DR Ensembl; ENST00000397022; ENSP00000380217; ENSG00000010704. [Q30201-5] DR Ensembl; ENST00000461397; ENSP00000420802; ENSG00000010704. [Q30201-3] DR Ensembl; ENST00000488199; ENSP00000420559; ENSG00000010704. [Q30201-4] DR GeneID; 3077; -. DR KEGG; hsa:3077; -. DR UCSC; uc003nfx.2; human. [Q30201-1] DR CTD; 3077; -. DR DisGeNET; 3077; -. DR EuPathDB; HostDB:ENSG00000010704.18; -. DR GeneCards; HFE; -. DR GeneReviews; HFE; -. DR H-InvDB; HIX0025100; -. DR HGNC; HGNC:4886; HFE. DR HPA; HPA017276; -. DR HPA; HPA053470; -. DR MalaCards; HFE; -. DR MIM; 176200; phenotype. DR MIM; 235200; phenotype. DR MIM; 612635; phenotype. DR MIM; 613609; gene. DR MIM; 614193; phenotype. DR neXtProt; NX_Q30201; -. DR OpenTargets; ENSG00000010704; -. DR Orphanet; 139498; Hemochromatosis type 1. DR Orphanet; 101330; Porphyria cutanea tarda. DR Orphanet; 79473; Porphyria variegata. DR PharmGKB; PA29263; -. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000151270; -. DR HOVERGEN; HBG016709; -. DR InParanoid; Q30201; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR PhylomeDB; Q30201; -. DR TreeFam; TF336617; -. DR Reactome; R-HSA-917977; Transferrin endocytosis and recycling. DR EvolutionaryTrace; Q30201; -. DR GeneWiki; HFE_(gene); -. DR GenomeRNAi; 3077; -. DR PRO; PR:Q30201; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000010704; Expressed in 196 organ(s), highest expression level in mononuclear cell. DR ExpressionAtlas; Q30201; baseline and differential. DR Genevisible; Q30201; HS. DR GO; GO:0045177; C:apical part of cell; IDA:UniProtKB. DR GO; GO:0045178; C:basal part of cell; IDA:UniProtKB. DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB. DR GO; GO:0005769; C:early endosome; IDA:UniProtKB. DR GO; GO:0009897; C:external side of plasma membrane; IDA:BHF-UCL. DR GO; GO:0005615; C:extracellular space; IDA:BHF-UCL. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IDA:BHF-UCL. DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055037; C:recycling endosome; IDA:UniProtKB. DR GO; GO:1990357; C:terminal web; IEA:Ensembl. DR GO; GO:0030881; F:beta-2-microglobulin binding; IPI:BHF-UCL. DR GO; GO:0039706; F:co-receptor binding; IPI:BHF-UCL. DR GO; GO:0005102; F:signaling receptor binding; IPI:UniProtKB. DR GO; GO:1990459; F:transferrin receptor binding; IPI:BHF-UCL. DR GO; GO:0006953; P:acute-phase response; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; IDA:BHF-UCL. DR GO; GO:0006879; P:cellular iron ion homeostasis; TAS:ProtInc. DR GO; GO:0071281; P:cellular response to iron ion; IGI:BHF-UCL. DR GO; GO:0010106; P:cellular response to iron ion starvation; IEA:Ensembl. DR GO; GO:0007565; P:female pregnancy; IEA:Ensembl. DR GO; GO:0042446; P:hormone biosynthetic process; IEA:Ensembl. DR GO; GO:0055072; P:iron ion homeostasis; IMP:BHF-UCL. DR GO; GO:0098711; P:iron ion import across plasma membrane; IDA:UniProtKB. DR GO; GO:0097421; P:liver regeneration; IEA:Ensembl. DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IEA:Ensembl. DR GO; GO:1904283; P:negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I; IGI:BHF-UCL. DR GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; IGI:BHF-UCL. DR GO; GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IC:BHF-UCL. DR GO; GO:1900121; P:negative regulation of receptor binding; IDA:BHF-UCL. DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IDA:BHF-UCL. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; IGI:BHF-UCL. DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IDA:BHF-UCL. DR GO; GO:1904434; P:positive regulation of ferrous iron binding; IGI:BHF-UCL. DR GO; GO:0010628; P:positive regulation of gene expression; ISS:BHF-UCL. DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IDA:BHF-UCL. DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IMP:BHF-UCL. DR GO; GO:0032092; P:positive regulation of protein binding; IGI:BHF-UCL. DR GO; GO:1900122; P:positive regulation of receptor binding; IGI:BHF-UCL. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IGI:BHF-UCL. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IGI:BHF-UCL. DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; IGI:BHF-UCL. DR GO; GO:0065003; P:protein-containing complex assembly; TAS:ProtInc. DR GO; GO:1900390; P:regulation of iron ion import; IGI:BHF-UCL. DR GO; GO:2000008; P:regulation of protein localization to cell surface; IMP:BHF-UCL. DR GO; GO:0010039; P:response to iron ion; IMP:BHF-UCL. DR GO; GO:1990641; P:response to iron ion starvation; IEA:Ensembl. DR GO; GO:0033572; P:transferrin transport; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Cell membrane; Complete proteome; KW Disease mutation; Disulfide bond; Glycoprotein; Ion transport; Iron; KW Iron transport; Membrane; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix; Transport. FT SIGNAL 1 22 FT CHAIN 23 348 Hereditary hemochromatosis protein. FT /FTId=PRO_0000018892. FT TOPO_DOM 23 306 Extracellular. FT {ECO:0000305|PubMed:9465039}. FT TRANSMEM 307 330 Helical. {ECO:0000255}. FT TOPO_DOM 331 348 Cytoplasmic. FT {ECO:0000305|PubMed:9465039}. FT DOMAIN 207 298 Ig-like C1-type. FT REGION 23 114 Alpha-1. FT REGION 115 205 Alpha-2. FT REGION 206 297 Alpha-3. FT REGION 298 306 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 130 130 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 234 234 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 124 187 FT DISULFID 225 282 FT VAR_SEQ 26 114 RSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVFYDHESR FT RVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIME FT NHNHSKE -> Q (in isoform 2 and isoform FT 4). {ECO:0000303|PubMed:10079302, FT ECO:0000303|PubMed:11358357}. FT /FTId=VSP_003218. FT VAR_SEQ 26 49 RSHSLHYLFMGASEQDLGLSLFEA -> P (in isoform FT 5). {ECO:0000303|PubMed:11358357}. FT /FTId=VSP_003219. FT VAR_SEQ 26 26 R -> Q (in isoform 11). FT {ECO:0000303|PubMed:11358357}. FT /FTId=VSP_043477. FT VAR_SEQ 26 26 R -> L (in isoform 6). FT {ECO:0000303|PubMed:11358357}. FT /FTId=VSP_047336. FT VAR_SEQ 27 298 Missing (in isoform 11). FT {ECO:0000303|PubMed:11358357}. FT /FTId=VSP_043478. FT VAR_SEQ 27 206 Missing (in isoform 6). FT {ECO:0000303|PubMed:11358357}. FT /FTId=VSP_003220. FT VAR_SEQ 114 219 Missing (in isoform 10). FT {ECO:0000303|PubMed:11001625}. FT /FTId=VSP_003222. FT VAR_SEQ 114 205 Missing (in isoform 7). FT {ECO:0000303|PubMed:11001625, FT ECO:0000303|PubMed:11358357}. FT /FTId=VSP_003221. FT VAR_SEQ 144 161 DHLEFCPDTLDWRAAEPR -> VLQDTIYSSEVSSLGIKF FT (in isoform 9). FT {ECO:0000303|PubMed:11001625}. FT /FTId=VSP_003223. FT VAR_SEQ 162 348 Missing (in isoform 9). FT {ECO:0000303|PubMed:11001625}. FT /FTId=VSP_003224. FT VAR_SEQ 207 220 Missing (in isoform 3 and isoform 4). FT {ECO:0000303|PubMed:10079302}. FT /FTId=VSP_003225. FT VAR_SEQ 275 276 GE -> KY (in isoform 8). FT {ECO:0000303|PubMed:11001625}. FT /FTId=VSP_003226. FT VAR_SEQ 277 348 Missing (in isoform 8). FT {ECO:0000303|PubMed:11001625}. FT /FTId=VSP_003227. FT VARIANT 6 6 R -> S (in HFE1; unknown pathological FT significance; dbSNP:rs149342416). FT {ECO:0000269|PubMed:12584229}. FT /FTId=VAR_042506. FT VARIANT 43 43 G -> D (in HFE1; associated with D-63 in FT one patient). FT {ECO:0000269|PubMed:18157833}. FT /FTId=VAR_042507. FT VARIANT 53 53 V -> M (in dbSNP:rs28934889). FT {ECO:0000269|PubMed:10401000, FT ECO:0000269|Ref.8}. FT /FTId=VAR_008111. FT VARIANT 59 59 V -> M (in dbSNP:rs111033557). FT {ECO:0000269|PubMed:10401000}. FT /FTId=VAR_008112. FT VARIANT 63 63 H -> D (polymorphism associated with FT hemochromatosis and variegate porphyria; FT increased frequency among patients with FT diabetic nephropathy; dbSNP:rs1799945). FT {ECO:0000269|PubMed:10094552, FT ECO:0000269|PubMed:10194428, FT ECO:0000269|PubMed:10401000, FT ECO:0000269|PubMed:11069625, FT ECO:0000269|PubMed:11423500, FT ECO:0000269|PubMed:18157833, FT ECO:0000269|PubMed:8696333, FT ECO:0000269|PubMed:9106528, FT ECO:0000269|PubMed:9425935, FT ECO:0000269|PubMed:9620340, FT ECO:0000269|Ref.8}. FT /FTId=VAR_004396. FT VARIANT 65 65 S -> C (in HFE1; mild form; FT dbSNP:rs1800730). FT {ECO:0000269|PubMed:10194428, FT ECO:0000269|PubMed:10575540, FT ECO:0000269|PubMed:12542741, FT ECO:0000269|PubMed:14633868, FT ECO:0000269|Ref.25}. FT /FTId=VAR_004397. FT VARIANT 66 66 R -> C (in HFE1; dbSNP:rs747739169). FT {ECO:0000269|PubMed:14633868}. FT /FTId=VAR_042508. FT VARIANT 93 93 G -> R (in HFE1; dbSNP:rs28934597). FT {ECO:0000269|PubMed:10575540}. FT /FTId=VAR_008729. FT VARIANT 105 105 I -> T (in HFE1; dbSNP:rs28934596). FT {ECO:0000269|PubMed:10575540}. FT /FTId=VAR_008730. FT VARIANT 127 127 Q -> H (in HFE1; dbSNP:rs28934595). FT {ECO:0000269|PubMed:10401000}. FT /FTId=VAR_008113. FT VARIANT 176 176 A -> V (in HFE1; uncertain pathological FT significance). FT {ECO:0000269|PubMed:11446670}. FT /FTId=VAR_042509. FT VARIANT 217 217 T -> I (in dbSNP:rs4986950). FT /FTId=VAR_020270. FT VARIANT 224 224 R -> G (in HFE1). FT {ECO:0000269|PubMed:14633868}. FT /FTId=VAR_042510. FT VARIANT 224 224 R -> Q (in dbSNP:rs62625346). FT {ECO:0000269|Ref.8}. FT /FTId=VAR_062279. FT VARIANT 277 277 E -> K (rare polymorphism; FT dbSNP:rs140080192). FT {ECO:0000269|PubMed:10612845}. FT /FTId=VAR_008731. FT VARIANT 282 282 C -> Y (in HFE1; associated with FT susceptibility to porphyria cutanea FT tarda; associated with increased serum FT transferrin levels; higher frequency in FT patients with type 2 diabetes than in FT controls; dbSNP:rs1800562). FT {ECO:0000269|PubMed:10094552, FT ECO:0000269|PubMed:10194428, FT ECO:0000269|PubMed:11069625, FT ECO:0000269|PubMed:11423500, FT ECO:0000269|PubMed:12542741, FT ECO:0000269|PubMed:14633868, FT ECO:0000269|PubMed:18157833, FT ECO:0000269|PubMed:8696333, FT ECO:0000269|PubMed:9024376, FT ECO:0000269|PubMed:9106528, FT ECO:0000269|PubMed:9620340, FT ECO:0000269|Ref.8}. FT /FTId=VAR_004398. FT VARIANT 283 283 Q -> P (in HFE1; destabilizing effect on FT the tertiary structure of the protein; FT prevents the normal interaction between FT HFE and B2M and between HFE and TFRC; FT decreases the capacity of HFE to reduce FT transferrin-mediated iron uptake; FT dbSNP:rs111033563). FT {ECO:0000269|PubMed:12737937, FT ECO:0000269|PubMed:15965644}. FT /FTId=VAR_037304. FT VARIANT 295 295 V -> A (in HFE1; dbSNP:rs143175221). FT {ECO:0000269|PubMed:12542741, FT ECO:0000269|PubMed:15046077}. FT /FTId=VAR_042511. FT VARIANT 330 330 R -> M (in HFE1; dbSNP:rs111033558). FT {ECO:0000269|PubMed:10401000}. FT /FTId=VAR_008114. FT CONFLICT 230 230 Y -> H (in Ref. 7; AAG29342). FT {ECO:0000305}. FT CONFLICT 248 248 A -> T (in Ref. 7; AAG29575). FT {ECO:0000305}. FT CONFLICT 256 256 V -> A (in Ref. 7; AAG29577). FT {ECO:0000305}. FT CONFLICT 275 275 G -> E (in Ref. 7; AAG29342). FT {ECO:0000305}. FT CONFLICT 311 311 S -> R (in Ref. 7; AAG29342). FT {ECO:0000305}. FT CONFLICT 339 339 M -> V (in Ref. 7; AAG29577). FT {ECO:0000305}. FT STRAND 28 38 {ECO:0000244|PDB:1A6Z}. FT STRAND 43 45 {ECO:0000244|PDB:1A6Z}. FT STRAND 48 53 {ECO:0000244|PDB:1A6Z}. FT STRAND 56 65 {ECO:0000244|PDB:1A6Z}. FT STRAND 68 70 {ECO:0000244|PDB:1A6Z}. FT HELIX 75 78 {ECO:0000244|PDB:1DE4}. FT TURN 79 82 {ECO:0000244|PDB:1A6Z}. FT HELIX 83 107 {ECO:0000244|PDB:1A6Z}. FT TURN 108 110 {ECO:0000244|PDB:1A6Z}. FT STRAND 112 114 {ECO:0000244|PDB:1A6Z}. FT STRAND 117 126 {ECO:0000244|PDB:1A6Z}. FT STRAND 132 140 {ECO:0000244|PDB:1A6Z}. FT STRAND 143 149 {ECO:0000244|PDB:1A6Z}. FT HELIX 150 152 {ECO:0000244|PDB:1A6Z}. FT STRAND 154 159 {ECO:0000244|PDB:1A6Z}. FT HELIX 160 162 {ECO:0000244|PDB:1A6Z}. FT HELIX 163 170 {ECO:0000244|PDB:1A6Z}. FT HELIX 174 184 {ECO:0000244|PDB:1A6Z}. FT HELIX 186 198 {ECO:0000244|PDB:1A6Z}. FT TURN 199 201 {ECO:0000244|PDB:1A6Z}. FT STRAND 209 216 {ECO:0000244|PDB:1A6Z}. FT STRAND 221 233 {ECO:0000244|PDB:1A6Z}. FT STRAND 236 241 {ECO:0000244|PDB:1A6Z}. FT HELIX 248 250 {ECO:0000244|PDB:1A6Z}. FT STRAND 255 258 {ECO:0000244|PDB:1A6Z}. FT STRAND 264 272 {ECO:0000244|PDB:1A6Z}. FT HELIX 276 279 {ECO:0000244|PDB:1A6Z}. FT STRAND 280 285 {ECO:0000244|PDB:1A6Z}. FT STRAND 289 291 {ECO:0000244|PDB:1A6Z}. FT STRAND 293 296 {ECO:0000244|PDB:1A6Z}. SQ SEQUENCE 348 AA; 40108 MW; 432EB9A314A55BEA CRC64; MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGASEQ DLGLSLFEAL GYVDDQLFVF YDHESRRVEP RTPWVSSRIS SQMWLQLSQS LKGWDHMFTV DFWTIMENHN HSKESHTLQV ILGCEMQEDN STEGYWKYGY DGQDHLEFCP DTLDWRAAEP RAWPTKLEWE RHKIRARQNR AYLERDCPAQ LQQLLELGRG VLDQQVPPLV KVTHHVTSSV TTLRCRALNY YPQNITMKWL KDKQPMDAKE FEPKDVLPNG DGTYQGWITL AVPPGEEQRY TCQVEHPGLD QPLIVIWEPS PSGTLVIGVI SGIAVFVVIL FIGILFIILR KRQGSRGAMG HYVLAERE // ID HFE_MOUSE Reviewed; 359 AA. AC P70387; Q14AQ5; Q5SZ90; Q9D754; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 27-JUL-2011, sequence version 2. DT 12-SEP-2018, entry version 143. DE RecName: Full=Hereditary hemochromatosis protein homolog; DE Flags: Precursor; GN Name=Hfe; Synonyms=Mr2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/SvJ; RX PubMed=9396865; DOI=10.1007/s002510050344; RA Riegert P., Gilfillan S., Nanda I., Schmid M., Bahram S.; RT "The mouse HFE gene."; RL Immunogenetics 47:174-177(1998). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=BALB/cJ; TISSUE=Lung; RA Hashimoto K.; RL Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Tongue; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-211. RC STRAIN=BALB/cJ; TISSUE=Liver; RX PubMed=9020055; DOI=10.1006/bbrc.1996.5889; RA Hashimoto K., Hirai M., Kurosawa Y.; RT "Identification of a mouse homolog for the human hereditary RT haemochromatosis candidate gene."; RL Biochem. Biophys. Res. Commun. 230:35-39(1997). RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 79-359. RC STRAIN=129; RA Albig W., Drabent B., Doenecke D.; RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases. RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Lung; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Binds to transferrin receptor (TFR) and reduces its CC affinity for iron-loaded transferrin. CC {ECO:0000250|UniProtKB:Q30201}. CC -!- SUBUNIT: Binds TFR through the extracellular domain in a pH- CC dependent manner. {ECO:0000250|UniProtKB:Q30201}. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000250|UniProtKB:Q30201}; Single-pass type I membrane CC protein {ECO:0000250|UniProtKB:Q30201}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AF007558; AAC03447.1; -; Genomic_DNA. DR EMBL; U66849; AAB07525.1; -; mRNA. DR EMBL; AK009581; BAB26373.1; -; mRNA. DR EMBL; AK150697; BAE29776.1; -; mRNA. DR EMBL; AL590388; CAI25849.2; -; Genomic_DNA. DR EMBL; CH466561; EDL32544.1; -; Genomic_DNA. DR EMBL; BC116744; AAI16745.1; -; mRNA. DR EMBL; BC116746; AAI16747.1; -; mRNA. DR EMBL; Y12650; CAA73197.1; -; Genomic_DNA. DR EMBL; U80604; AAB51504.1; -; Genomic_DNA. DR CCDS; CCDS26360.1; -. DR PIR; JC5382; JC5382. DR RefSeq; NP_001334422.1; NM_001347493.1. DR RefSeq; NP_034554.2; NM_010424.5. DR UniGene; Mm.2681; -. DR ProteinModelPortal; P70387; -. DR SMR; P70387; -. DR BioGrid; 200285; 1. DR STRING; 10090.ENSMUSP00000089298; -. DR iPTMnet; P70387; -. DR PhosphoSitePlus; P70387; -. DR MaxQB; P70387; -. DR PaxDb; P70387; -. DR PeptideAtlas; P70387; -. DR PRIDE; P70387; -. DR Ensembl; ENSMUST00000091706; ENSMUSP00000089298; ENSMUSG00000006611. DR GeneID; 15216; -. DR KEGG; mmu:15216; -. DR UCSC; uc007pup.1; mouse. DR CTD; 3077; -. DR MGI; MGI:109191; Hfe. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; P70387; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-917977; Transferrin endocytosis and recycling. DR PRO; PR:P70387; -. DR Proteomes; UP000000589; Chromosome 13. DR Bgee; ENSMUSG00000006611; Expressed in 203 organ(s), highest expression level in epididymal fat pad. DR CleanEx; MM_HFE; -. DR ExpressionAtlas; P70387; baseline and differential. DR Genevisible; P70387; MM. DR GO; GO:0045177; C:apical part of cell; ISO:MGI. DR GO; GO:0045178; C:basal part of cell; ISO:MGI. DR GO; GO:0031410; C:cytoplasmic vesicle; ISO:MGI. DR GO; GO:0005769; C:early endosome; ISO:MGI. DR GO; GO:0009897; C:external side of plasma membrane; ISO:MGI. DR GO; GO:0005615; C:extracellular space; ISO:MGI. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IDA:BHF-UCL. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI. DR GO; GO:0055037; C:recycling endosome; ISO:MGI. DR GO; GO:1990357; C:terminal web; ISO:MGI. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0039706; F:co-receptor binding; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:1990459; F:transferrin receptor binding; IPI:BHF-UCL. DR GO; GO:0006953; P:acute-phase response; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; ISO:MGI. DR GO; GO:0071281; P:cellular response to iron ion; ISO:MGI. DR GO; GO:0010106; P:cellular response to iron ion starvation; IEA:Ensembl. DR GO; GO:0007565; P:female pregnancy; IEA:Ensembl. DR GO; GO:0042446; P:hormone biosynthetic process; IMP:MGI. DR GO; GO:0055072; P:iron ion homeostasis; IMP:MGI. DR GO; GO:0098711; P:iron ion import across plasma membrane; IMP:MGI. DR GO; GO:0097421; P:liver regeneration; IEA:Ensembl. DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IMP:MGI. DR GO; GO:1904283; P:negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I; ISO:MGI. DR GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; ISO:MGI. DR GO; GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IC:BHF-UCL. DR GO; GO:1900121; P:negative regulation of receptor binding; ISO:MGI. DR GO; GO:2000272; P:negative regulation of signaling receptor activity; ISO:MGI. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; ISO:MGI. DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; ISO:MGI. DR GO; GO:1904434; P:positive regulation of ferrous iron binding; ISO:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; IMP:BHF-UCL. DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISO:MGI. DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; ISO:MGI. DR GO; GO:0032092; P:positive regulation of protein binding; ISO:MGI. DR GO; GO:1900122; P:positive regulation of receptor binding; ISO:MGI. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; ISO:MGI. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; ISO:MGI. DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; ISO:MGI. DR GO; GO:1900390; P:regulation of iron ion import; ISO:MGI. DR GO; GO:2000008; P:regulation of protein localization to cell surface; ISO:MGI. DR GO; GO:0010039; P:response to iron ion; ISO:MGI. DR GO; GO:1990641; P:response to iron ion starvation; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; KW Ion transport; Iron; Iron transport; Membrane; Reference proteome; KW Signal; Transmembrane; Transmembrane helix; Transport. FT SIGNAL 1 24 {ECO:0000255}. FT CHAIN 25 359 Hereditary hemochromatosis protein FT homolog. FT /FTId=PRO_0000018894. FT TOPO_DOM 25 318 Extracellular. FT {ECO:0000250|UniProtKB:Q30201}. FT TRANSMEM 319 339 Helical. {ECO:0000255}. FT TOPO_DOM 340 359 Cytoplasmic. FT {ECO:0000250|UniProtKB:Q30201}. FT DOMAIN 219 308 Ig-like C1-type. FT REGION 25 126 Alpha-1. FT REGION 127 217 Alpha-2. FT REGION 218 309 Alpha-3. FT REGION 310 318 Connecting peptide. FT CARBOHYD 114 114 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 142 142 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 166 166 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 246 246 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 136 199 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 237 294 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT CONFLICT 327 327 V -> I (in Ref. 1; AAC03447, 2; AAB07525, FT 6; AAI16745/AAI16747 and 8; CAA73197). FT {ECO:0000305}. SQ SEQUENCE 359 AA; 40534 MW; 586657B7F9FF20B4 CRC64; MSLSAGLPVR PLLLLLLLLW SVAPQALPPR SHSLRYLFMG ASEPDLGLPL FEARGYVDDQ LFVSYNHESR RAEPRAPWIL EQTSSQLWLH LSQSLKGWDY MFIVDFWTIM GNYNHSKVTK LGVVSESHIL QVVLGCEVHE DNSTSGFWRY GYDGQDHLEF CPKTLNWSAA EPGAWATKVE WDEHKIRAKQ NRDYLEKDCP EQLKRLLELG RGVLGQQVPT LVKVTRHWAS TGTSLRCQAL DFFPQNITMR WLKDNQPLDA KDVNPEKVLP NGDETYQGWL TLAVAPGDET RFTCQVEHPG LDQPLTASWE PLQSQAMIIG IISGVTVCAI FLVGILFLIL RKRKASGGTM GGYVLTDCE // ID HFE_PANTR Reviewed; 348 AA. AC P60018; DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot. DT 21-NOV-2003, sequence version 1. DT 23-MAY-2018, entry version 98. DE RecName: Full=Hereditary hemochromatosis protein homolog; DE Flags: Precursor; GN Name=HFE; Synonyms=Patr-H; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=12196404; RA Toomajian C., Kreitman M.; RT "Sequence variation and haplotype structure at the Human HFE Locus."; RL Genetics 161:1609-1623(2002). CC -!- FUNCTION: Binds to transferrin receptor (TFR) and reduces its CC affinity for iron-loaded transferrin. CC {ECO:0000250|UniProtKB:Q30201}. CC -!- SUBUNIT: Binds TFR through the extracellular domain in a pH- CC dependent manner. {ECO:0000250|UniProtKB:Q30201}. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000250|UniProtKB:Q30201}; Single-pass type I membrane CC protein {ECO:0000250|UniProtKB:Q30201}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AF447807; AAN09793.1; -; Genomic_DNA. DR RefSeq; NP_001009101.1; NM_001009101.1. DR UniGene; Ptr.6185; -. DR ProteinModelPortal; P60018; -. DR SMR; P60018; -. DR STRING; 9598.ENSPTRP00000056517; -. DR PaxDb; P60018; -. DR GeneID; 462489; -. DR KEGG; ptr:462489; -. DR CTD; 3077; -. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; P60018; -. DR Proteomes; UP000002277; Unplaced. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IBA:GO_Central. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; KW Ion transport; Iron; Iron transport; Membrane; Reference proteome; KW Signal; Transmembrane; Transmembrane helix; Transport. FT SIGNAL 1 22 {ECO:0000250}. FT CHAIN 23 348 Hereditary hemochromatosis protein FT homolog. FT /FTId=PRO_0000018893. FT TOPO_DOM 23 306 Extracellular. FT {ECO:0000250|UniProtKB:Q30201}. FT TRANSMEM 307 330 Helical. {ECO:0000255}. FT TOPO_DOM 331 348 Cytoplasmic. FT {ECO:0000250|UniProtKB:Q30201}. FT DOMAIN 207 298 Ig-like C1-type. FT REGION 23 114 Alpha-1. FT REGION 115 205 Alpha-2. FT REGION 206 297 Alpha-3. FT REGION 298 306 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 130 130 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 234 234 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 124 187 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 225 282 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 348 AA; 40108 MW; 432EB9A314A55BEA CRC64; MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGASEQ DLGLSLFEAL GYVDDQLFVF YDHESRRVEP RTPWVSSRIS SQMWLQLSQS LKGWDHMFTV DFWTIMENHN HSKESHTLQV ILGCEMQEDN STEGYWKYGY DGQDHLEFCP DTLDWRAAEP RAWPTKLEWE RHKIRARQNR AYLERDCPAQ LQQLLELGRG VLDQQVPPLV KVTHHVTSSV TTLRCRALNY YPQNITMKWL KDKQPMDAKE FEPKDVLPNG DGTYQGWITL AVPPGEEQRY TCQVEHPGLD QPLIVIWEPS PSGTLVIGVI SGIAVFVVIL FIGILFIILR KRQGSRGAMG HYVLAERE // ID HFE_RAT Reviewed; 360 AA. AC O35799; O35175; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 12-SEP-2018, entry version 138. DE RecName: Full=Hereditary hemochromatosis protein homolog; DE AltName: Full=RT1-CAFE; DE Flags: Precursor; GN Name=Hfe; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Liver; RA Banasch M.W., Schaefer H., Schmidt W.E.; RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 42-303. RC TISSUE=Small intestine; RA Sawada-Hirai R., Rothenberg B.E.; RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Binds to transferrin receptor (TFR) and reduces its CC affinity for iron-loaded transferrin. CC {ECO:0000250|UniProtKB:Q30201}. CC -!- SUBUNIT: Binds TFR through the extracellular domain in a pH- CC dependent manner. {ECO:0000250|UniProtKB:Q30201}. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000250|UniProtKB:Q30201}; Single-pass type I membrane CC protein {ECO:0000250|UniProtKB:Q30201}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AJ001517; CAA04799.1; -; mRNA. DR EMBL; AF008587; AAB86597.1; -; mRNA. DR RefSeq; NP_445753.1; NM_053301.4. DR UniGene; Rn.42931; -. DR ProteinModelPortal; O35799; -. DR SMR; O35799; -. DR STRING; 10116.ENSRNOP00000022881; -. DR PaxDb; O35799; -. DR PRIDE; O35799; -. DR Ensembl; ENSRNOT00000022881; ENSRNOP00000022881; ENSRNOG00000016967. DR GeneID; 29199; -. DR KEGG; rno:29199; -. DR UCSC; RGD:2793; rat. DR CTD; 3077; -. DR RGD; 2793; Hfe. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; O35799; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR PhylomeDB; O35799; -. DR TreeFam; TF336617; -. DR Reactome; R-RNO-917977; Transferrin endocytosis and recycling. DR PRO; PR:O35799; -. DR Proteomes; UP000002494; Chromosome 17. DR Bgee; ENSRNOG00000016967; Expressed in 9 organ(s), highest expression level in liver. DR ExpressionAtlas; O35799; baseline and differential. DR Genevisible; O35799; RN. DR GO; GO:0045177; C:apical part of cell; IDA:RGD. DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:Ensembl. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl. DR GO; GO:1990357; C:terminal web; IDA:RGD. DR GO; GO:0030881; F:beta-2-microglobulin binding; IEA:Ensembl. DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl. DR GO; GO:0006953; P:acute-phase response; IEP:RGD. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0006879; P:cellular iron ion homeostasis; TAS:RGD. DR GO; GO:0071281; P:cellular response to iron ion; IEA:Ensembl. DR GO; GO:0010106; P:cellular response to iron ion starvation; IEP:RGD. DR GO; GO:0007565; P:female pregnancy; IEP:RGD. DR GO; GO:0042446; P:hormone biosynthetic process; IEA:Ensembl. DR GO; GO:0055072; P:iron ion homeostasis; IEP:RGD. DR GO; GO:0098711; P:iron ion import across plasma membrane; IBA:GO_Central. DR GO; GO:0097421; P:liver regeneration; IEP:RGD. DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IEA:Ensembl. DR GO; GO:1904283; P:negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:Ensembl. DR GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; IEA:Ensembl. DR GO; GO:1900121; P:negative regulation of receptor binding; IEA:Ensembl. DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; IEA:Ensembl. DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR GO; GO:1904434; P:positive regulation of ferrous iron binding; IEA:Ensembl. DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl. DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl. DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IEA:Ensembl. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; IEA:Ensembl. DR GO; GO:1900390; P:regulation of iron ion import; IEA:Ensembl. DR GO; GO:2000008; P:regulation of protein localization to cell surface; IEA:Ensembl. DR GO; GO:1990641; P:response to iron ion starvation; IEP:RGD. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; KW Ion transport; Iron; Iron transport; Membrane; Reference proteome; KW Signal; Transmembrane; Transmembrane helix; Transport. FT SIGNAL 1 25 {ECO:0000255}. FT CHAIN 26 360 Hereditary hemochromatosis protein FT homolog. FT /FTId=PRO_0000018895. FT TOPO_DOM 26 319 Extracellular. FT {ECO:0000250|UniProtKB:Q30201}. FT TRANSMEM 320 340 Helical. {ECO:0000255}. FT TOPO_DOM 341 360 Cytoplasmic. FT {ECO:0000250|UniProtKB:Q30201}. FT DOMAIN 220 309 Ig-like C1-type. FT REGION 26 127 Alpha-1. FT REGION 128 218 Alpha-2. FT REGION 219 310 Alpha-3. FT REGION 311 319 Connecting peptide. FT CARBOHYD 115 115 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 143 143 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 167 167 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 247 247 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 137 200 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 238 295 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT CONFLICT 198 198 R -> K (in Ref. 2; AAB86597). FT {ECO:0000305}. SQ SEQUENCE 360 AA; 40988 MW; CC819834EE3240B3 CRC64; MDRSAGLPVR LLLLLLLLLL WSVAPQALRP GSHSLRYLFM GASKPDLGLP FFEALGYVDD QLFVSYNHES RRAEPRAPWI LGQTSSQLWL QLSQSLKGWD YMFIVDFWTI MGNYNHSKVT KLRVVPESHI LQVILGCEVH EDNSTSGFWK YGYDGQDHLE FCPKTLNWSA AEPRAWATKM EWEEHRIRAR QSRDYLQRDC PQQLKQVLEL QRGVLGQQVP TLVKVTRHWA STGTSLRCQA LNFFPQNITM RWLKDSQPLD AKDVNPENVL PNGDGTYQGW LTLAVAPGEE TRFSCQVEHP GLDQPLTATW EPSRSQDMII GIISGITICA IFFVGILILV LRKRKVSGGT MGDYVLTECE // ID HLAE_HUMAN Reviewed; 358 AA. AC P13747; Q30169; Q9BT83; Q9GIY7; Q9GIY8; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 29-AUG-2003, sequence version 3. DT 18-JUL-2018, entry version 186. DE RecName: Full=HLA class I histocompatibility antigen, alpha chain E; DE AltName: Full=MHC class I antigen E; DE Flags: Precursor; GN Name=HLA-E; Synonyms=HLA-6.2, HLAE; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE E*01:01). RX PubMed=3131426; RA Mizuno S., Trapani J.A., Koller B.H., Dupont B., Yang S.Y.; RT "Isolation and nucleotide sequence of a cDNA clone encoding a novel RT HLA class I gene."; RL J. Immunol. 140:4024-4030(1988). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELES E*01:01 AND E*01:03). RX PubMed=10064069; RX DOI=10.1002/(SICI)1521-4141(199902)29:02<537::AID-IMMU537>3.0.CO;2-6; RA Ulbrecht M., Courturier A., Martinozzi S., Pla M., Srivastava R., RA Peterson P.A., Weiss E.H.; RT "Cell surface expression of HLA-E: interaction with human beta-2 RT microglobulin and allelic differences."; RL Eur. J. Immunol. 29:537-547(1999). RN [3] RP NUCLEOTIDE SEQUENCE (ALLELES E*01:01 AND E*01:03). RA Ishitani A., Miki A., Williams L.M., Moore Y., Geraghty D.E.; RT "HLA-E, F, and G polymorphism: genomic sequence defines new variation RT spanning the nonclassical class I genes."; RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE E*01:01). RA Shiina S., Tamiya G., Oka A., Inoko H.; RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE E*01:01). RC TISSUE=Ovarian adenocarcinoma, and Pancreas; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE E*01:02). RX PubMed=3260916; RA Koller B.H., Geraghty D.E., Shimizu Y., Demars R., Orr H.T.; RT "HLA-E. A novel HLA class I gene expressed in resting T lymphocytes."; RL J. Immunol. 141:897-904(1988). RN [7] RP NUCLEOTIDE SEQUENCE (ALLELE E*01:03). RA Ulbrecht M.; RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE E*01:03). RA He X., Xu L., Liu Y., Zeng Y.; RT "A new variant of HLA-E*010303 with three synonymous mutations."; RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE E*01:03). RA He X., Xu L., Liu Y., Zeng Y.; RT "Cloning of HLA-E cDNA from activated peripheral leukocytes."; RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 112-203 (ALLELE E*01:04). RC TISSUE=Peripheral blood; RX PubMed=1977695; DOI=10.1007/BF02114975; RA Ohya K., Kondo K., Mizuno S.; RT "Polymorphism in the human class I MHC locus HLA-E in Japanese."; RL Immunogenetics 32:205-209(1990). RN [11] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-107. RC TISSUE=Leukemic T-cell; RX PubMed=19349973; DOI=10.1038/nbt.1532; RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., RA Schiess R., Aebersold R., Watts J.D.; RT "Mass-spectrometric identification and relative quantification of N- RT linked cell surface glycoproteins."; RL Nat. Biotechnol. 27:378-386(2009). RN [12] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [13] RP X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 22-295. RX PubMed=9660937; DOI=10.1016/S1097-2765(00)80053-2; RA O'Callaghan C.A., Tormo J., Willcox B.E., Braud V.M., Jakobsen B.K., RA Stuart D.I., McMichael A.J., Bell J.I., Jones E.Y.; RT "Structural features impose tight peptide binding specificity in the RT nonclassical MHC molecule HLA-E."; RL Mol. Cell 1:531-541(1998). RN [14] RP POLYMORPHISM, AND QUESTIONING ON ALLELES E*01:02 AND E*01:04. RX PubMed=12445303; DOI=10.1034/j.1399-0039.2002.600302.x; RA Grimsley C., Kawasaki A., Gassner C., Sageshima N., Nose Y., RA Hatake K., Geraghty D.E., Ishitani A.; RT "Definitive high resolution typing of HLA-E allelic polymorphisms: RT identifying potential errors in existing allele data."; RL Tissue Antigens 60:206-212(2002). CC -!- FUNCTION: Preferably binds to a peptide derived from the signal CC sequence of most HLA-A, -B, -C and -G molecules. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- INTERACTION: CC P30511:HLA-F; NbExp=2; IntAct=EBI-726583, EBI-2811134; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- POLYMORPHISM: The following alleles of E-1 are known: E*01:01, CC E*01:02, E*01:03 and E*01:04. The sequence shown is that of CC E*01:01. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC -!- CAUTION: The existence of allele E*01:02 (PubMed:3260916) and CC allele E*01:04 (PubMed:1977695) is uncertain. The alleles could CC not be confirmed in further studies (PubMed:12445303). CC {ECO:0000305|PubMed:12445303, ECO:0000305|PubMed:1977695, CC ECO:0000305|PubMed:3260916}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M20022; AAA52655.1; -; mRNA. DR EMBL; AJ293263; CAC07212.1; -; mRNA. DR EMBL; AJ293264; CAC07213.1; -; mRNA. DR EMBL; AF523274; AAM74969.1; -; Genomic_DNA. DR EMBL; AF523275; AAM74970.1; -; Genomic_DNA. DR EMBL; AF523276; AAM74971.1; -; Genomic_DNA. DR EMBL; AF523277; AAM74972.1; -; Genomic_DNA. DR EMBL; AF523278; AAM74973.1; -; Genomic_DNA. DR EMBL; AF523279; AAM74974.1; -; Genomic_DNA. DR EMBL; AF523280; AAM74975.1; -; Genomic_DNA. DR EMBL; AF523281; AAM74976.1; -; Genomic_DNA. DR EMBL; AF523282; AAM74977.1; -; Genomic_DNA. DR EMBL; AF523283; AAM74978.1; -; Genomic_DNA. DR EMBL; BA000025; BAB63328.1; -; Genomic_DNA. DR EMBL; BC002578; AAH02578.1; -; mRNA. DR EMBL; BC004297; AAH04297.1; -; mRNA. DR EMBL; M21533; AAA59835.1; -; Genomic_DNA. DR EMBL; AY221103; AAO34408.1; -; mRNA. DR EMBL; AY216681; AAO37688.1; -; mRNA. DR EMBL; M32508; AAA63225.1; -; Genomic_DNA. DR CCDS; CCDS34379.1; -. DR PIR; A28834; A28834. DR RefSeq; NP_005507.3; NM_005516.5. DR UniGene; Hs.650174; -. DR PDB; 1KPR; X-ray; 2.80 A; A/C=22-295. DR PDB; 1KTL; X-ray; 3.10 A; A/C=22-295. DR PDB; 1MHE; X-ray; 2.85 A; A/C=22-295. DR PDB; 2ESV; X-ray; 2.60 A; A=23-297. DR PDB; 3AM8; X-ray; 2.80 A; A/B=22-297. DR PDB; 3BZE; X-ray; 2.50 A; A/C/E/G=23-295. DR PDB; 3BZF; X-ray; 2.50 A; A/C=22-297. DR PDB; 3CDG; X-ray; 3.40 A; A/C=23-295. DR PDB; 3CII; X-ray; 4.41 A; A/D=23-295. DR PDB; 5W1V; X-ray; 3.31 A; A/F/K/P=22-299. DR PDB; 5W1W; X-ray; 3.10 A; A/F/K/P=22-299. DR PDBsum; 1KPR; -. DR PDBsum; 1KTL; -. DR PDBsum; 1MHE; -. DR PDBsum; 2ESV; -. DR PDBsum; 3AM8; -. DR PDBsum; 3BZE; -. DR PDBsum; 3BZF; -. DR PDBsum; 3CDG; -. DR PDBsum; 3CII; -. DR PDBsum; 5W1V; -. DR PDBsum; 5W1W; -. DR ProteinModelPortal; P13747; -. DR SMR; P13747; -. DR BioGrid; 109378; 51. DR DIP; DIP-32N; -. DR IntAct; P13747; 21. DR STRING; 9606.ENSP00000365817; -. DR iPTMnet; P13747; -. DR PhosphoSitePlus; P13747; -. DR SwissPalm; P13747; -. DR BioMuta; HLA-E; -. DR DMDM; 34395942; -. DR EPD; P13747; -. DR PaxDb; P13747; -. DR PeptideAtlas; P13747; -. DR PRIDE; P13747; -. DR ProteomicsDB; 52981; -. DR TopDownProteomics; P13747; -. DR DNASU; 3133; -. DR Ensembl; ENST00000383597; ENSP00000373091; ENSG00000206493. DR Ensembl; ENST00000415289; ENSP00000409910; ENSG00000229252. DR Ensembl; ENST00000415649; ENSP00000390707; ENSG00000233904. DR Ensembl; ENST00000427936; ENSP00000397420; ENSG00000230254. DR GeneID; 3133; -. DR KEGG; hsa:3133; -. DR CTD; 3133; -. DR DisGeNET; 3133; -. DR GeneCards; HLA-E; -. DR HGNC; HGNC:4962; HLA-E. DR HPA; HPA031454; -. DR MIM; 143010; gene. DR neXtProt; NX_P13747; -. DR PharmGKB; PA35081; -. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR HOVERGEN; HBG016709; -. DR InParanoid; P13747; -. DR KO; K06751; -. DR OrthoDB; EOG091G09OH; -. DR PhylomeDB; P13747; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-2172127; DAP12 interactions. DR Reactome; R-HSA-2424491; DAP12 signaling. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR SIGNOR; P13747; -. DR ChiTaRS; HLA-E; human. DR EvolutionaryTrace; P13747; -. DR GeneWiki; HLA-E; -. DR GenomeRNAi; 3133; -. DR PRO; PR:P13747; -. DR Proteomes; UP000005640; Chromosome 6. DR CleanEx; HS_HLA-E; -. DR GO; GO:0009986; C:cell surface; IDA:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0042612; C:MHC class I protein complex; IDA:UniProtKB. DR GO; GO:0032398; C:MHC class Ib protein complex; IDA:UniProtKB. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; IDA:UniProtKB. DR GO; GO:0042288; F:MHC class I protein binding; IDA:UniProtKB. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IPI:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; IDA:UniProtKB. DR GO; GO:0005102; F:signaling receptor binding; IPI:UniProtKB. DR GO; GO:0042608; F:T cell receptor binding; IDA:UniProtKB. DR GO; GO:0002250; P:adaptive immune response; IDA:UniProtKB. DR GO; GO:0019731; P:antibacterial humoral response; IDA:UniProtKB. DR GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; IDA:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0036037; P:CD8-positive, alpha-beta T cell activation; IDA:UniProtKB. DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB. DR GO; GO:0045087; P:innate immune response; TAS:Reactome. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:2000566; P:positive regulation of CD8-positive, alpha-beta T cell proliferation; IDA:UniProtKB. DR GO; GO:0051024; P:positive regulation of immunoglobulin secretion; IDA:UniProtKB. DR GO; GO:0032736; P:positive regulation of interleukin-13 production; IDA:UniProtKB. DR GO; GO:0032753; P:positive regulation of interleukin-4 production; IDA:UniProtKB. DR GO; GO:0002717; P:positive regulation of natural killer cell mediated immunity; IDA:UniProtKB. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0032759; P:positive regulation of TRAIL production; IDA:UniProtKB. DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IDA:UniProtKB. DR GO; GO:0042270; P:protection from natural killer cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0002715; P:regulation of natural killer cell mediated immunity; IDA:UniProtKB. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Phosphoprotein; Polymorphism; KW Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 21 FT CHAIN 22 358 HLA class I histocompatibility antigen, FT alpha chain E. FT /FTId=PRO_0000018882. FT TOPO_DOM 22 305 Extracellular. {ECO:0000255}. FT TRANSMEM 306 329 Helical. {ECO:0000255}. FT TOPO_DOM 330 358 Cytoplasmic. {ECO:0000255}. FT DOMAIN 206 294 Ig-like C1-type. FT REGION 22 111 Alpha-1. FT REGION 112 203 Alpha-2. FT REGION 204 295 Alpha-3. FT REGION 296 305 Connecting peptide. FT MOD_RES 353 353 Phosphoserine. FT {ECO:0000250|UniProtKB:P01900}. FT CARBOHYD 107 107 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:19349973}. FT DISULFID 122 185 FT DISULFID 224 280 FT VARIANT 98 98 N -> K (in dbSNP:rs1059510). FT /FTId=VAR_059510. FT VARIANT 104 104 G -> R (in allele E*01:02). FT /FTId=VAR_004395. FT VARIANT 128 128 R -> G (in allele E*01:03 and allele FT E*01:04; dbSNP:rs1264457). FT /FTId=VAR_016651. FT VARIANT 178 178 R -> G (in allele E*01:04; FT dbSNP:rs41562314). FT /FTId=VAR_016652. FT CONFLICT 10 10 L -> S (in Ref. 1; AAA52655). FT {ECO:0000305}. FT STRAND 24 33 {ECO:0000244|PDB:3BZE}. FT STRAND 36 40 {ECO:0000244|PDB:3BZE}. FT STRAND 42 49 {ECO:0000244|PDB:3BZE}. FT STRAND 52 58 {ECO:0000244|PDB:3BZE}. FT STRAND 61 63 {ECO:0000244|PDB:3BZE}. FT STRAND 65 68 {ECO:0000244|PDB:1KPR}. FT HELIX 71 73 {ECO:0000244|PDB:3BZE}. FT STRAND 74 76 {ECO:0000244|PDB:5W1V}. FT HELIX 78 105 {ECO:0000244|PDB:3BZE}. FT STRAND 110 112 {ECO:0000244|PDB:3BZE}. FT STRAND 115 124 {ECO:0000244|PDB:3BZE}. FT STRAND 128 139 {ECO:0000244|PDB:3BZE}. FT STRAND 142 147 {ECO:0000244|PDB:3BZE}. FT STRAND 151 158 {ECO:0000244|PDB:3BZE}. FT HELIX 159 161 {ECO:0000244|PDB:3BZE}. FT HELIX 162 170 {ECO:0000244|PDB:3BZE}. FT TURN 171 173 {ECO:0000244|PDB:3BZE}. FT HELIX 174 182 {ECO:0000244|PDB:3BZE}. FT HELIX 184 195 {ECO:0000244|PDB:3BZE}. FT HELIX 197 200 {ECO:0000244|PDB:3BZE}. FT STRAND 207 214 {ECO:0000244|PDB:3BZE}. FT STRAND 216 232 {ECO:0000244|PDB:3BZE}. FT STRAND 235 239 {ECO:0000244|PDB:3BZE}. FT TURN 241 243 {ECO:0000244|PDB:1KPR}. FT STRAND 249 251 {ECO:0000244|PDB:3BZF}. FT STRAND 258 260 {ECO:0000244|PDB:3BZE}. FT STRAND 262 271 {ECO:0000244|PDB:3BZE}. FT HELIX 275 277 {ECO:0000244|PDB:3BZE}. FT STRAND 279 283 {ECO:0000244|PDB:3BZE}. FT STRAND 287 289 {ECO:0000244|PDB:3BZE}. FT STRAND 291 293 {ECO:0000244|PDB:3BZE}. SQ SEQUENCE 358 AA; 40157 MW; 2A211B603591D248 CRC64; MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD DTQFVRFDND AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR TLRGYYNQSE AGSHTLQWMH GCELGPDRRF LRGYEQFAYD GKDYLTLNED LRSWTAVDTA AQISEQKSND ASEAEHQRAY LEDTCVEWLH KYLEKGKETL LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ DGEGHTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTLRWKPASQ PTIPIVGIIA GLVLLGSVVS GAVVAAVIWR KKSSGGKGGS YSKAEWSDSA QGSESHSL // ID HLAE_PANTR Reviewed; 350 AA. AC Q95IT3; DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 12-SEP-2018, entry version 102. DE RecName: Full=Patr class I histocompatibility antigen, alpha chain E; DE AltName: Full=MHC class I antigen E; DE Flags: Precursor; GN Name=Patr-E; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=11398964; DOI=10.1007/s002510100318; RA Adams E.J., Parham P.; RT "Genomic analysis of common chimpanzee major histocompatibility RT complex class I genes."; RL Immunogenetics 53:200-208(2001). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12799463; DOI=10.1073/pnas.1230533100; RA Anzai T., Shiina T., Kimura N., Yanagiya K., Kohara S., Shigenari A., RA Yamagata T., Kulski J.K., Naruse T.K., Fujimori Y., Fukuzumi Y., RA Yamazaki M., Tashiro H., Iwamoto C., Umehara Y., Imanishi T., RA Meyer A., Ikeo K., Gojobori T., Bahram S., Inoko H.; RT "Comparative sequencing of human and chimpanzee MHC class I regions RT unveils insertions/deletions as the major path to genomic RT divergence."; RL Proc. Natl. Acad. Sci. U.S.A. 100:7708-7713(2003). CC -!- FUNCTION: Preferably binds to a peptide derived from the signal CC sequence of most HLA-A, -B, -C and -G molecules. {ECO:0000250}. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I CC membrane protein {ECO:0000250}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AF338354; AAK77478.1; -; Genomic_DNA. DR EMBL; BA000041; BAC78182.1; -; Genomic_DNA. DR RefSeq; NP_001038963.1; NM_001045498.1. DR UniGene; Ptr.2716; -. DR ProteinModelPortal; Q95IT3; -. DR SMR; Q95IT3; -. DR STRING; 9598.ENSPTRP00000054601; -. DR PaxDb; Q95IT3; -. DR PRIDE; Q95IT3; -. DR GeneID; 462540; -. DR KEGG; ptr:462540; -. DR CTD; 462540; -. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; Q95IT3; -. DR KO; K06751; -. DR OMA; SALTKTW; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002277; Unplaced. DR Bgee; ENSPTRG00000017912; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 21 {ECO:0000250}. FT CHAIN 22 350 Patr class I histocompatibility antigen, FT alpha chain E. FT /FTId=PRO_0000018883. FT TOPO_DOM 22 305 Extracellular. {ECO:0000255}. FT TRANSMEM 306 329 Helical. {ECO:0000255}. FT TOPO_DOM 330 350 Cytoplasmic. {ECO:0000255}. FT DOMAIN 206 294 Ig-like C1-type. FT REGION 22 111 Alpha-1. FT REGION 112 203 Alpha-2. FT REGION 204 295 Alpha-3. FT REGION 296 305 Connecting peptide. FT CARBOHYD 107 107 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 122 185 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 224 280 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 350 AA; 39379 MW; CD3364274632D95E CRC64; MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD DTQFVRFDND AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR TLRGYYNQSE AGSHTLQWMH GCDLGPDGRF LRGYEQFAYD GKDYLTLNED LRSWTAVDTA AQISERKSND ACEAEHQRAY LEDTCVEWLH KYLEKGKETL LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ DGEGHTQDTE LVDTRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP LTLRWKPASQ PTIPIVGIIA GLVLLGSVVS GAVVAAVMWR KKSSGGKGRS YSKAEWSDSA // ID HLAF_HUMAN Reviewed; 346 AA. AC P30511; Q5JQI8; Q5JQJ1; Q5SPT5; Q860R0; Q8MGQ1; Q8WLP5; Q95HC0; AC Q9TP68; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 11-JAN-2011, sequence version 3. DT 12-SEP-2018, entry version 167. DE RecName: Full=HLA class I histocompatibility antigen, alpha chain F; DE AltName: Full=CDA12; DE AltName: Full=HLA F antigen; DE AltName: Full=Leukocyte antigen F; DE AltName: Full=MHC class I antigen F; DE Flags: Precursor; GN Name=HLA-F; Synonyms=HLA-5.4, HLAF; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1), RP AND VARIANT SER-272. RX PubMed=1688605; DOI=10.1084/jem.171.1.1; RA Geraghty D.E., Wei X., Orr H.T., Koller B.H.; RT "Human leukocyte antigen F (HLA-F). An expressed HLA gene composed of RT a class I coding sequence linked to a novel transcribed repetitive RT element."; RL J. Exp. Med. 171:1-18(1990). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1), RP AND VARIANT SER-272. RX PubMed=1707659; DOI=10.1093/intimm/2.6.531; RA Lury D., Epstein H., Holmes N.; RT "The human class I MHC gene HLA-F is expressed in lymphocytes."; RL Int. Immunol. 2:531-537(1990). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1), RP AND VARIANT SER-272. RX PubMed=10727083; DOI=10.3109/10425179909033955; RA Hampe A., Coriton O., Andrieux N., Carn G., Lepourcelet M., RA Mottier S., Dreano S., Gatius M.T., Hitte C., Soriano N., Galibert F.; RT "A 356-Kb sequence of the subtelomeric part of the MHC class I RT region."; RL DNA Seq. 10:263-299(1999). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANT SER-272. RX PubMed=14705989; DOI=10.1111/j.1399-0039.2004.00145.x; RA He X., Xu L., Liu Y., Zeng Y.; RT "Identification of a novel HLA-F allele - HLA-F*010102."; RL Tissue Antigens 63:181-183(2004). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1), RP AND VARIANT SER-272. RX PubMed=16570139; DOI=10.1007/s00251-005-0076-z; RA Pyo C.W., Williams L.M., Moore Y., Hyodo H., Li S.S., Zhao L.P., RA Sageshima N., Ishitani A., Geraghty D.E.; RT "HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines RT haplotype structure and variation spanning the nonclassical class I RT genes."; RL Immunogenetics 58:241-251(2006). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT SER-272. RA Gharwan H., Sageshima N., Ishitani A., Geraghty D.E.; RT "A comparative study of the MHC-F expression patterns between humans RT and nonhuman primates."; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT SER-272. RA Shiina S., Tamiya G., Oka A., Inoko H.; RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT SER-272. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT RP SER-272. RC TISSUE=Lung, and Lymph; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- INTERACTION: CC P13747:HLA-E; NbExp=2; IntAct=EBI-2811134, EBI-726583; CC P43632:KIR2DS4; NbExp=4; IntAct=EBI-2811134, EBI-13916812; CC P43629:KIR3DL1; NbExp=4; IntAct=EBI-2811134, EBI-3910993; CC P43630:KIR3DL2; NbExp=6; IntAct=EBI-2811134, EBI-6165894; CC Q14943:KIR3DS1; NbExp=6; IntAct=EBI-2811134, EBI-15316524; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=P30511-1; Sequence=Displayed; CC Name=2; CC IsoId=P30511-2; Sequence=VSP_038846; CC Name=3; CC IsoId=P30511-3; Sequence=VSP_040349; CC Note=Ref.10 (AAH09260) sequence is in conflict in position: CC 353:N->L. {ECO:0000305}; CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAC24827.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC Sequence=AAH09260.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; CC Sequence=BAB63337.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC Sequence=CAA34947.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC Sequence=CAB46623.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X17093; CAA34947.1; ALT_SEQ; Genomic_DNA. DR EMBL; AF055066; AAC24827.1; ALT_SEQ; Genomic_DNA. DR EMBL; AY253269; AAO86773.1; -; mRNA. DR EMBL; AY253270; AAO86774.1; -; mRNA. DR EMBL; AY253271; AAO86775.1; -; mRNA. DR EMBL; AF523284; AAM74979.1; -; Genomic_DNA. DR EMBL; AF523285; AAM74980.1; -; Genomic_DNA. DR EMBL; AF523286; AAM74981.1; -; Genomic_DNA. DR EMBL; AF523287; AAM74982.1; -; Genomic_DNA. DR EMBL; AF523288; AAM74983.1; -; Genomic_DNA. DR EMBL; AF523289; AAM74984.1; -; Genomic_DNA. DR EMBL; AF523290; AAM74985.1; -; Genomic_DNA. DR EMBL; AF523291; AAM74986.1; -; Genomic_DNA. DR EMBL; AF523292; AAM74987.1; -; Genomic_DNA. DR EMBL; AF523293; AAM74988.1; -; Genomic_DNA. DR EMBL; AF523294; AAM74989.1; -; Genomic_DNA. DR EMBL; AF523295; AAM74990.1; -; Genomic_DNA. DR EMBL; AF523296; AAM74991.1; -; Genomic_DNA. DR EMBL; AF523297; AAM74992.1; -; Genomic_DNA. DR EMBL; AY645742; AAT73225.1; -; Genomic_DNA. DR EMBL; AY645743; AAT73226.1; -; Genomic_DNA. DR EMBL; AY645744; AAT73227.1; -; Genomic_DNA. DR EMBL; AY645745; AAT73228.1; -; Genomic_DNA. DR EMBL; AY645746; AAT73229.1; -; Genomic_DNA. DR EMBL; AY645748; AAT73231.1; -; Genomic_DNA. DR EMBL; AY645749; AAT73232.1; -; Genomic_DNA. DR EMBL; AY645750; AAT73233.1; -; Genomic_DNA. DR EMBL; AY645751; AAT73234.1; -; Genomic_DNA. DR EMBL; AY645752; AAT73235.1; -; Genomic_DNA. DR EMBL; AY645753; AAT73236.1; -; Genomic_DNA. DR EMBL; AY645754; AAT73237.1; -; Genomic_DNA. DR EMBL; AY645756; AAT73239.1; -; Genomic_DNA. DR EMBL; AY645757; AAT73240.1; -; Genomic_DNA. DR EMBL; AY645758; AAT73241.1; -; Genomic_DNA. DR EMBL; AY645759; AAT73242.1; -; Genomic_DNA. DR EMBL; DQ367723; ABD38924.1; -; mRNA. DR EMBL; BA000025; BAB63337.1; ALT_SEQ; Genomic_DNA. DR EMBL; AL022723; CAB46623.1; ALT_SEQ; Genomic_DNA. DR EMBL; AL645939; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL669813; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL844851; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX005428; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR753818; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX927250; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471081; EAX03223.1; -; Genomic_DNA. DR EMBL; CH471081; EAX03226.1; -; Genomic_DNA. DR EMBL; BC009260; AAH09260.2; ALT_INIT; mRNA. DR EMBL; BC062991; AAH62991.1; -; mRNA. DR CCDS; CCDS43437.1; -. [P30511-3] DR CCDS; CCDS43438.1; -. [P30511-1] DR CCDS; CCDS43439.1; -. [P30511-2] DR PIR; A60384; A60384. DR RefSeq; NP_001091948.1; NM_001098478.1. [P30511-2] DR RefSeq; NP_001091949.1; NM_001098479.1. [P30511-3] DR RefSeq; NP_061823.2; NM_018950.2. [P30511-1] DR UniGene; Hs.519972; -. DR PDB; 5IUE; X-ray; 2.62 A; A/E/G/I=22-305. DR PDB; 5KNM; X-ray; 3.30 A; A=22-305. DR PDBsum; 5IUE; -. DR PDBsum; 5KNM; -. DR ProteinModelPortal; P30511; -. DR SMR; P30511; -. DR BioGrid; 109379; 20. DR IntAct; P30511; 11. DR STRING; 9606.ENSP00000259951; -. DR iPTMnet; P30511; -. DR PhosphoSitePlus; P30511; -. DR BioMuta; HLA-F; -. DR DMDM; 317373438; -. DR EPD; P30511; -. DR PaxDb; P30511; -. DR PeptideAtlas; P30511; -. DR PRIDE; P30511; -. DR ProteomicsDB; 54704; -. DR ProteomicsDB; 54705; -. [P30511-2] DR ProteomicsDB; 54706; -. [P30511-3] DR DNASU; 3134; -. DR Ensembl; ENST00000259951; ENSP00000259951; ENSG00000204642. [P30511-3] DR Ensembl; ENST00000334668; ENSP00000334263; ENSG00000204642. [P30511-1] DR Ensembl; ENST00000359076; ENSP00000351977; ENSG00000206509. [P30511-2] DR Ensembl; ENST00000376848; ENSP00000366044; ENSG00000229698. [P30511-2] DR Ensembl; ENST00000376861; ENSP00000366057; ENSG00000204642. [P30511-1] DR Ensembl; ENST00000383515; ENSP00000373007; ENSG00000137403. [P30511-2] DR Ensembl; ENST00000420067; ENSP00000393535; ENSG00000235220. [P30511-2] DR Ensembl; ENST00000434407; ENSP00000397376; ENSG00000204642. [P30511-2] DR Ensembl; ENST00000440590; ENSP00000399835; ENSG00000237508. [P30511-2] DR GeneID; 3134; -. DR KEGG; hsa:3134; -. DR UCSC; uc003nnm.5; human. [P30511-1] DR CTD; 3134; -. DR DisGeNET; 3134; -. DR EuPathDB; HostDB:ENSG00000204642.13; -. DR GeneCards; HLA-F; -. DR HGNC; HGNC:4963; HLA-F. DR MIM; 143110; gene. DR neXtProt; NX_P30511; -. DR OpenTargets; ENSG00000204642; -. DR PharmGKB; PA35082; -. DR eggNOG; ENOG410IUXN; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; P30511; -. DR KO; K06751; -. DR OMA; RITQRFY; -. DR PhylomeDB; P30511; -. DR TreeFam; TF336617; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR SIGNOR; P30511; -. DR ChiTaRS; HLA-F; human. DR GeneWiki; HLA-F; -. DR GenomeRNAi; 3134; -. DR PRO; PR:P30511; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204642; Expressed in 237 organ(s), highest expression level in blood. DR CleanEx; HS_HLA-F; -. DR ExpressionAtlas; P30511; baseline and differential. DR Genevisible; P30511; HS. DR GO; GO:0009986; C:cell surface; IDA:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0016020; C:membrane; HDA:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0046978; F:TAP1 binding; IPI:UniProtKB. DR GO; GO:0046979; F:TAP2 binding; IPI:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Complete proteome; Disulfide bond; KW Glycoprotein; Immunity; Membrane; MHC I; Polymorphism; KW Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 21 FT CHAIN 22 346 HLA class I histocompatibility antigen, FT alpha chain F. FT /FTId=PRO_0000018884. FT TOPO_DOM 22 305 Extracellular. {ECO:0000255}. FT TRANSMEM 306 329 Helical. {ECO:0000255}. FT TOPO_DOM 330 346 Cytoplasmic. {ECO:0000255}. FT DOMAIN 206 296 Ig-like C1-type. FT REGION 22 111 Alpha-1. FT REGION 112 203 Alpha-2. FT REGION 204 295 Alpha-3. FT REGION 296 305 Connecting peptide. FT CARBOHYD 107 107 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 122 185 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 224 280 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VAR_SEQ 204 295 Missing (in isoform 2). FT {ECO:0000303|PubMed:14705989}. FT /FTId=VSP_038846. FT VAR_SEQ 346 346 V -> AYSVVSGNLMITWWSSLFLLGVLFQGYLGCLRSHSV FT LGRRKVGDMWILFFLWLWTSFNTAFLALQSLRFGFGFRRGR FT SFLLRSWHHLMKRVQIKIFD (in isoform 3). FT {ECO:0000303|PubMed:15489334}. FT /FTId=VSP_040349. FT VARIANT 13 13 A -> V (in dbSNP:rs17875379). FT /FTId=VAR_056525. FT VARIANT 71 71 P -> Q (in dbSNP:rs17875380). FT /FTId=VAR_056526. FT VARIANT 272 272 P -> S (in dbSNP:rs1736924). FT {ECO:0000269|PubMed:10727083, FT ECO:0000269|PubMed:14574404, FT ECO:0000269|PubMed:14705989, FT ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:16570139, FT ECO:0000269|PubMed:1688605, FT ECO:0000269|PubMed:1707659, FT ECO:0000269|Ref.6, ECO:0000269|Ref.7}. FT /FTId=VAR_018327. FT STRAND 24 35 {ECO:0000244|PDB:5IUE}. FT TURN 36 38 {ECO:0000244|PDB:5IUE}. FT STRAND 39 49 {ECO:0000244|PDB:5IUE}. FT STRAND 52 58 {ECO:0000244|PDB:5IUE}. FT STRAND 61 63 {ECO:0000244|PDB:5IUE}. FT STRAND 67 70 {ECO:0000244|PDB:5IUE}. FT HELIX 71 73 {ECO:0000244|PDB:5IUE}. FT HELIX 78 105 {ECO:0000244|PDB:5IUE}. FT STRAND 115 124 {ECO:0000244|PDB:5IUE}. FT STRAND 128 139 {ECO:0000244|PDB:5IUE}. FT STRAND 142 147 {ECO:0000244|PDB:5IUE}. FT STRAND 154 158 {ECO:0000244|PDB:5IUE}. FT HELIX 161 170 {ECO:0000244|PDB:5IUE}. FT HELIX 173 182 {ECO:0000244|PDB:5IUE}. FT HELIX 184 195 {ECO:0000244|PDB:5IUE}. FT HELIX 197 200 {ECO:0000244|PDB:5IUE}. FT STRAND 207 214 {ECO:0000244|PDB:5IUE}. FT STRAND 216 232 {ECO:0000244|PDB:5IUE}. FT STRAND 235 240 {ECO:0000244|PDB:5IUE}. FT TURN 246 248 {ECO:0000244|PDB:5KNM}. FT STRAND 249 251 {ECO:0000244|PDB:5IUE}. FT STRAND 258 260 {ECO:0000244|PDB:5IUE}. FT STRAND 262 271 {ECO:0000244|PDB:5IUE}. FT HELIX 275 277 {ECO:0000244|PDB:5IUE}. FT STRAND 278 283 {ECO:0000244|PDB:5IUE}. FT STRAND 287 289 {ECO:0000244|PDB:5IUE}. FT STRAND 291 293 {ECO:0000244|PDB:5IUE}. SQ SEQUENCE 346 AA; 39062 MW; D4782968A67E9B7D CRC64; MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL QRADPPKAHV AHHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPAGDG TFQKWAAVVV PPGEEQRYTC HVQHEGLPQP LILRWEQSPQ PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAV // ID HLAF_MACMU Reviewed; 348 AA. AC P33617; DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot. DT 08-APR-2008, sequence version 2. DT 23-MAY-2018, entry version 105. DE RecName: Full=Mamu class I histocompatibility antigen, alpha chain F; DE AltName: Full=Leukocyte antigen F; DE AltName: Full=MHC class I antigen F; DE Flags: Precursor; GN Name=Mamu-F; Synonyms=HLAF; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=8482576; DOI=10.1007/BF00190901; RA Otting N., Bontrop R.E.; RT "Characterization of the rhesus macaque (Macaca mulatta) equivalent of RT HLA-F."; RL Immunogenetics 38:141-145(1993). RN [2] RP SEQUENCE REVISION TO 39; 49; 212; 217; 234; 333 AND 346-347. RA Otting N.; RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; Z21819; CAA79885.2; -; mRNA. DR PIR; S29990; S29990. DR RefSeq; NP_001036235.2; NM_001042770.2. DR UniGene; Mmu.3379; -. DR ProteinModelPortal; P33617; -. DR SMR; P33617; -. DR STRING; 9544.ENSMMUP00000011541; -. DR GeneID; 709076; -. DR KEGG; mcc:709076; -. DR CTD; 709076; -. DR eggNOG; ENOG410IUXN; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; P33617; -. DR KO; K06751; -. DR Proteomes; UP000006718; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; KW MHC I; Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 21 {ECO:0000250}. FT CHAIN 22 348 Mamu class I histocompatibility antigen, FT alpha chain F. FT /FTId=PRO_0000018885. FT TOPO_DOM 22 307 Extracellular. {ECO:0000255}. FT TRANSMEM 308 331 Helical. {ECO:0000255}. FT TOPO_DOM 332 348 Cytoplasmic. {ECO:0000255}. FT DOMAIN 208 296 Ig-like C1-type. FT REGION 22 113 Alpha-1. FT REGION 114 205 Alpha-2. FT REGION 206 297 Alpha-3. FT REGION 298 307 Connecting peptide. FT CARBOHYD 109 109 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 124 187 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 226 282 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 348 AA; 39481 MW; 010108EA2FDE4EAD CRC64; MAPRTLLLVL SGALALTETW AGSHSLRYFS TAVSRPGRRE PQYRYIAVEY VDDTQFLRFD SDAAIPRMEP RAPWVEQEGP QYWERTTGYA KANARTDRVA LRKLLLRYNQ SEAGSHTLQG MNGCDMGPDG RLLRGYHQHA YDGKDYISLN EDLRSWTAAD TVARITQRFY EAEEYAEEFR TYLEGECLEL LRRYLENGKE TLQRADPPKA HVAHHPISDR EATLRCWALG FYPAEITLTW QRDGEEQTQD TELVETRPAG DGTFQKWAAV VVPSGEEQRY TCHVQHEGLP QPLTLRWESS SQPTIPIVGI VAGLAVLAVV VTGAVVAAVM WRRKSSDRNR GSYSQPTM // ID HLAG_HUMAN Reviewed; 338 AA. AC P17693; DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1990, sequence version 1. DT 12-SEP-2018, entry version 183. DE RecName: Full=HLA class I histocompatibility antigen, alpha chain G; DE AltName: Full=HLA G antigen; DE AltName: Full=MHC class I antigen G; DE Flags: Precursor; GN Name=HLA-G; Synonyms=HLA-6.0, HLAG; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY. RC TISSUE=Fetal eye; RX PubMed=2336406; DOI=10.1093/nar/18.8.2189; RA Shukla H., Swaroop A., Srivastava R., Weissman S.M.; RT "The mRNA of a human class I gene HLA G/HLA 6.0 exhibits a restricted RT pattern of expression."; RL Nucleic Acids Res. 18:2189-2189(1990). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=3480534; DOI=10.1073/pnas.84.24.9145; RA Geraghty D.E., Koller B.H., Orr H.T.; RT "A human major histocompatibility complex class I gene that encodes a RT protein with a shortened cytoplasmic segment."; RL Proc. Natl. Acad. Sci. U.S.A. 84:9145-9149(1987). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Placenta; RA Ishitani A., Geraghty D.E.; RL Submitted (APR-1992) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=10727083; DOI=10.3109/10425179909033955; RA Hampe A., Coriton O., Andrieux N., Carn G., Lepourcelet M., RA Mottier S., Dreano S., Gatius M.T., Hitte C., Soriano N., Galibert F.; RT "A 356-Kb sequence of the subtelomeric part of the MHC class I RT region."; RL DNA Seq. 10:263-299(1999). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Shiina S., Tamiya G., Oka A., Inoko H.; RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. RN [6] RP ALTERNATIVE SPLICING (ISOFORMS 1; 2 AND 3), AND TISSUE SPECIFICITY. RX PubMed=1570318; RA Ishitani A., Geraghty D.E.; RT "Alternative splicing of HLA-G transcripts yields proteins with RT primary structures resembling both class I and class II antigens."; RL Proc. Natl. Acad. Sci. U.S.A. 89:3947-3951(1992). RN [7] RP ALTERNATIVE SPLICING (ISOFORM 4), AND TISSUE SPECIFICITY (ISOFORM RP HLA-G4). RX PubMed=7589701; RA Moreau P., Teyssier M., Kirszenbaum M., Gluckman E., Gourand L., RA Carosella E., Dausset J.; RT "HLA-G mRNA forms in human trophoblasts and peripheral blood RT lymphocytes: potential use in prenatal diagnosis."; RL Folia Biol. (Praha) 40:431-438(1994). RN [8] RP ALTERNATIVE SPLICING (ISOFORMS 5 AND 6). RX PubMed=7989753; RA Fujii T., Ishitani A., Geraghty D.E.; RT "A soluble form of the HLA-G antigen is encoded by a messenger RT ribonucleic acid containing intron 4."; RL J. Immunol. 153:5516-5524(1994). RN [9] RP ALTERNATIVE SPLICING (ISOFORM 4). RX PubMed=8183892; RA Kirszenbaum M., Moreau P., Gluckman E., Dausset J., Carosella E.; RT "An alternatively spliced form of HLA-G mRNA in human trophoblasts and RT evidence for the presence of HLA-G transcript in adult lymphocytes."; RL Proc. Natl. Acad. Sci. U.S.A. 91:4209-4213(1994). RN [10] RP ALTERNATIVE SPLICING (ISOFORM 5), AND SUBCELLULAR LOCATION (ISOFORM RP 5). RX PubMed=7558941; RA Moreau P., Carosella E., Teyssier M., Prost S., Gluckman E., RA Dausset J., Kirszenbaum M.; RT "Soluble HLA-G molecule. An alternatively spliced HLA-G mRNA form RT candidate to encode it in peripheral blood mononuclear cells and human RT trophoblasts."; RL Hum. Immunol. 43:231-236(1995). RN [11] RP ALTERNATIVE SPLICING (ISOFORM 7), SUBCELLULAR LOCATION (ISOFORM 5), RP AND TISSUE SPECIFICITY (ISOFORM 7). RX PubMed=11137219; RA Paul P., Cabestre F.A., Ibrahim E.C., Lefebvre S., Khalil-Daher I., RA Vazeux G., Quiles R.M., Bermond F., Dausset J., Carosella E.D.; RT "Identification of HLA-G7 as a new splice variant of the HLA-G mRNA RT and expression of soluble HLA-G5, -G6, and -G7 transcripts in human RT transfected cells."; RL Hum. Immunol. 61:1138-1149(2000). RN [12] RP SUBUNIT, MUTAGENESIS OF CYS-66, AND DISULFIDE BOND AT CYS-66. RX PubMed=12454284; DOI=10.1073/pnas.212643199; RA Boyson J.E., Erskine R., Whitman M.C., Chiu M., Lau J.M., RA Koopman L.A., Valter M.M., Angelisova P., Horejsi V., Strominger J.L.; RT "Disulfide bond-mediated dimerization of HLA-G on the cell surface."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16180-16185(2002). RN [13] RP SUBUNIT (ISOFORM 2), INTERACTION WITH LILRB2 (ISOFORM 2), AND RP MUTAGENESIS OF CYS-66. RX PubMed=28348268; DOI=10.4049/jimmunol.1601296; RA Kuroki K., Mio K., Takahashi A., Matsubara H., Kasai Y., Manaka S., RA Kikkawa M., Hamada D., Sato C., Maenaka K.; RT "Class II-like structural features and strong receptor binding of the RT nonclassical HLA-G2 isoform homodimer."; RL J. Immunol. 198:3399-3403(2017). RN [14] RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 26-300. RX PubMed=15718280; DOI=10.1073/pnas.0409676102; RA Clements C.S., Kjer-Nielsen L., Kostenko L., Hoare H.L., RA Dunstone M.A., Moses E., Freed K., Brooks A.G., Rossjohn J., RA McCluskey J.; RT "Crystal structure of HLA-G: a nonclassical MHC class I molecule RT expressed at the fetal-maternal interface."; RL Proc. Natl. Acad. Sci. U.S.A. 102:3360-3365(2005). RN [15] RP X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 25-300, DISULFIDE BONDS, AND RP INTERACTION WITH LILRB1 AND LILRB2. RX PubMed=16455647; DOI=10.1074/jbc.M512305200; RA Shiroishi M., Kuroki K., Ose T., Rasubala L., Shiratori I., Arase H., RA Tsumoto K., Kumagai I., Kohda D., Maenaka K.; RT "Efficient leukocyte Ig-like receptor signaling and crystal structure RT of disulfide-linked HLA-G dimer."; RL J. Biol. Chem. 281:10439-10447(2006). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. Plays a role in maternal tolerance of the fetus by CC mediating protection from the deleterious effects of natural CC killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear CC cells. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). Homodimer; disulfide-linked (PubMed:12454284, CC PubMed:16455647). Binds to LILRB1 and LILRB2 (PubMed:16455647). CC Isoform 2: Forms a non-disulfide-linked homodimer and interacts CC with LILRB2 (PubMed:28348268). {ECO:0000269|PubMed:12454284, CC ECO:0000269|PubMed:16455647, ECO:0000269|PubMed:28348268}. CC -!- INTERACTION: CC Self; NbExp=5; IntAct=EBI-1043063, EBI-1043063; CC Q8NHL6:LILRB1; NbExp=5; IntAct=EBI-1043063, EBI-2805262; CC Q8N423:LILRB2; NbExp=7; IntAct=EBI-1043063, EBI-2816428; CC -!- SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000305}; CC Single-pass type I membrane protein {ECO:0000255}. CC -!- SUBCELLULAR LOCATION: Isoform 2: Cell membrane {ECO:0000305}; CC Single-pass type I membrane protein {ECO:0000255}. CC -!- SUBCELLULAR LOCATION: Isoform 3: Cell membrane {ECO:0000305}; CC Single-pass type I membrane protein {ECO:0000255}. CC -!- SUBCELLULAR LOCATION: Isoform 4: Cell membrane {ECO:0000305}; CC Single-pass type I membrane protein {ECO:0000255}. CC -!- SUBCELLULAR LOCATION: Isoform 5: Secreted CC {ECO:0000269|PubMed:11137219, ECO:0000269|PubMed:7558941}. CC -!- SUBCELLULAR LOCATION: Isoform 6: Secreted {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Isoform 7: Secreted {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=7; CC Name=1; Synonyms=HLA-G1 {ECO:0000303|PubMed:1570318}; CC IsoId=P17693-1; Sequence=Displayed; CC Name=2; Synonyms=HLA-G2 {ECO:0000303|PubMed:1570318}; CC IsoId=P17693-2; Sequence=VSP_059192, VSP_059195; CC Name=3; Synonyms=HLA-G3 {ECO:0000303|PubMed:1570318}; CC IsoId=P17693-3; Sequence=VSP_059191; CC Name=4; Synonyms=HLA-G.3-5 {ECO:0000303|PubMed:8183892}, HLA-G4 CC {ECO:0000303|PubMed:7589701}; CC IsoId=P17693-4; Sequence=VSP_059196; CC Name=5; Synonyms=HLA-G1sol {ECO:0000303|PubMed:7989753}, HLA-G5 CC {ECO:0000303|PubMed:7558941}; CC IsoId=P17693-5; Sequence=VSP_059197; CC Name=6; Synonyms=HLA-G2sol {ECO:0000303|PubMed:7989753}, HLA-G6 CC {ECO:0000303|PubMed:11137219}; CC IsoId=P17693-6; Sequence=VSP_059192, VSP_059195, VSP_059197; CC Name=7; Synonyms=HLA-G7 {ECO:0000303|PubMed:11137219}; CC IsoId=P17693-7; Sequence=VSP_059193, VSP_059194; CC -!- TISSUE SPECIFICITY: Expressed in trophoblasts. Expressed in fetal CC eye and thymus (PubMed:2336406). Also expressed in adult eye CC (PubMed:1570318). Isoform 4: Expressed in fetal first trimester CC trophoblasts (PubMed:7589701). Isoform 7: Expressed in first CC trimester, second trimester and term placenta, fetal liver, CC amniotic membrane, skin, cord blood and peripheral blood CC mononuclear cells (PubMed:11137219). {ECO:0000269|PubMed:11137219, CC ECO:0000269|PubMed:1570318, ECO:0000269|PubMed:2336406, CC ECO:0000269|PubMed:7589701}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology CC and Haematology; CC URL="http://atlasgeneticsoncology.org/Genes/HLAGID43744ch6p22.html"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X17273; CAA35174.1; -; mRNA. DR EMBL; J03027; AAA98745.1; -; Genomic_DNA. DR EMBL; M90683; AAA52673.1; -; mRNA. DR EMBL; AF055066; AAC24826.1; -; Genomic_DNA. DR EMBL; BA000025; BAB63336.1; -; Genomic_DNA. DR CCDS; CCDS4668.1; -. [P17693-1] DR PIR; A39953; A39953. DR RefSeq; NP_002118.1; NM_002127.5. [P17693-1] DR UniGene; Hs.512152; -. DR PDB; 1YDP; X-ray; 1.90 A; A=26-300. DR PDB; 2D31; X-ray; 3.20 A; A/D=25-300. DR PDB; 2DYP; X-ray; 2.50 A; A=25-300. DR PDB; 3BZE; X-ray; 2.50 A; P/Q/R/S=3-11. DR PDB; 3CDG; X-ray; 3.40 A; P/Q=3-11. DR PDB; 3CII; X-ray; 4.41 A; C/F=3-11. DR PDB; 3KYN; X-ray; 2.40 A; A=26-299. DR PDB; 3KYO; X-ray; 1.70 A; A/C=26-298. DR PDBsum; 1YDP; -. DR PDBsum; 2D31; -. DR PDBsum; 2DYP; -. DR PDBsum; 3BZE; -. DR PDBsum; 3CDG; -. DR PDBsum; 3CII; -. DR PDBsum; 3KYN; -. DR PDBsum; 3KYO; -. DR ProteinModelPortal; P17693; -. DR SMR; P17693; -. DR BioGrid; 109380; 18. DR DIP; DIP-46121N; -. DR IntAct; P17693; 7. DR MINT; P17693; -. DR STRING; 9606.ENSP00000353472; -. DR iPTMnet; P17693; -. DR PhosphoSitePlus; P17693; -. DR SwissPalm; P17693; -. DR BioMuta; HLA-G; -. DR DMDM; 122132; -. DR EPD; P17693; -. DR PaxDb; P17693; -. DR PeptideAtlas; P17693; -. DR PRIDE; P17693; -. DR ProteomicsDB; 53506; -. DR DNASU; 3135; -. DR Ensembl; ENST00000360323; ENSP00000353472; ENSG00000204632. [P17693-1] DR Ensembl; ENST00000376815; ENSP00000366011; ENSG00000204632. [P17693-3] DR Ensembl; ENST00000383621; ENSP00000373116; ENSG00000206506. [P17693-1] DR Ensembl; ENST00000383622; ENSP00000373117; ENSG00000206506. [P17693-3] DR Ensembl; ENST00000415687; ENSP00000389969; ENSG00000237216. [P17693-3] DR Ensembl; ENST00000423011; ENSP00000389522; ENSG00000233095. [P17693-1] DR Ensembl; ENST00000423373; ENSP00000405238; ENSG00000235346. [P17693-1] DR Ensembl; ENST00000428701; ENSP00000412927; ENSG00000204632. [P17693-1] DR Ensembl; ENST00000428952; ENSP00000388176; ENSG00000235680. [P17693-1] DR Ensembl; ENST00000429890; ENSP00000401326; ENSG00000235680. [P17693-3] DR Ensembl; ENST00000444098; ENSP00000398200; ENSG00000230413. [P17693-1] DR Ensembl; ENST00000445373; ENSP00000416408; ENSG00000230413. [P17693-3] DR Ensembl; ENST00000448306; ENSP00000413926; ENSG00000233095. [P17693-3] DR Ensembl; ENST00000449127; ENSP00000408773; ENSG00000237216. [P17693-1] DR Ensembl; ENST00000457132; ENSP00000410247; ENSG00000235346. [P17693-3] DR Ensembl; ENST00000546545; ENSP00000447762; ENSG00000230413. [P17693-1] DR Ensembl; ENST00000546634; ENSP00000447780; ENSG00000235346. [P17693-1] DR Ensembl; ENST00000547241; ENSP00000448085; ENSG00000233095. [P17693-1] DR Ensembl; ENST00000547931; ENSP00000448363; ENSG00000237216. [P17693-1] DR Ensembl; ENST00000550897; ENSP00000449903; ENSG00000235680. [P17693-1] DR Ensembl; ENST00000553052; ENSP00000449291; ENSG00000206506. [P17693-1] DR Ensembl; ENST00000622601; ENSP00000479399; ENSG00000276051. [P17693-3] DR GeneID; 3135; -. DR KEGG; hsa:3135; -. DR CTD; 3135; -. DR DisGeNET; 3135; -. DR EuPathDB; HostDB:ENSG00000204632.11; -. DR GeneCards; HLA-G; -. DR H-InvDB; HIX0166674; -. DR H-InvDB; HIX0167370; -. DR HGNC; HGNC:4964; HLA-G. DR HPA; CAB016158; -. DR MalaCards; HLA-G; -. DR MIM; 142871; gene. DR neXtProt; NX_P17693; -. DR OpenTargets; ENSG00000204632; -. DR PharmGKB; PA35083; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR InParanoid; P17693; -. DR KO; K06751; -. DR PhylomeDB; P17693; -. DR TreeFam; TF336617; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR SIGNOR; P17693; -. DR ChiTaRS; HLA-G; human. DR EvolutionaryTrace; P17693; -. DR GeneWiki; HLA-G; -. DR GenomeRNAi; 3135; -. DR PRO; PR:P17693; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204632; Expressed in 233 organ(s), highest expression level in blood. DR CleanEx; HS_HLA-G; -. DR ExpressionAtlas; P17693; baseline and differential. DR Genevisible; P17693; HS. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0016020; C:membrane; HDA:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0042802; F:identical protein binding; IPI:IntAct. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB. DR GO; GO:0005102; F:signaling receptor binding; IPI:UniProtKB. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006968; P:cellular defense response; TAS:ProtInc. DR GO; GO:0002767; P:immune response-inhibiting cell surface receptor signaling pathway; IDA:BHF-UCL. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:2001199; P:negative regulation of dendritic cell differentiation; IDA:BHF-UCL. DR GO; GO:0050777; P:negative regulation of immune response; IC:UniProtKB. DR GO; GO:0042130; P:negative regulation of T cell proliferation; IDA:BHF-UCL. DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IDA:BHF-UCL. DR GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; IMP:BHF-UCL. DR GO; GO:0002666; P:positive regulation of T cell tolerance induction; IMP:BHF-UCL. DR GO; GO:0002645; P:positive regulation of tolerance induction; IMP:UniProtKB. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Cell membrane; Complete proteome; KW Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I; KW Reference proteome; Secreted; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 FT CHAIN 25 338 HLA class I histocompatibility antigen, FT alpha chain G. FT /FTId=PRO_0000018886. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 338 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 299 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 66 66 Interchain. {ECO:0000255|PROSITE- FT ProRule:PRU00114, FT ECO:0000269|PubMed:12454284}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:16455647}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:16455647}. FT VAR_SEQ 115 298 Missing (in isoform 3). FT {ECO:0000269|PubMed:1570318}. FT /FTId=VSP_059191. FT VAR_SEQ 115 206 Missing (in isoform 2 and isoform 6). FT {ECO:0000269|PubMed:1570318}. FT /FTId=VSP_059192. FT VAR_SEQ 116 116 S -> E (in isoform 7). FT {ECO:0000269|PubMed:11137219}. FT /FTId=VSP_059193. FT VAR_SEQ 117 338 Missing (in isoform 7). FT {ECO:0000269|PubMed:11137219}. FT /FTId=VSP_059194. FT VAR_SEQ 207 298 Missing (in isoform 4). FT {ECO:0000269|PubMed:7589701, FT ECO:0000269|PubMed:8183892}. FT /FTId=VSP_059196. FT VAR_SEQ 207 207 D -> K (in isoform 2 and isoform 6). FT {ECO:0000269|PubMed:1570318}. FT /FTId=VSP_059195. FT VAR_SEQ 299 338 KQSSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD FT -> SKEGDGGIMSVRESRSLSEDL (in isoform 5 FT and isoform 6). FT {ECO:0000269|PubMed:7989753}. FT /FTId=VSP_059197. FT MUTAGEN 66 66 C->S: Abolishes homodimerization. Does FT not affect binding of isoform 2 to FT LILRB2. {ECO:0000269|PubMed:12454284, FT ECO:0000269|PubMed:28348268}. FT STRAND 27 36 {ECO:0000244|PDB:3KYO}. FT STRAND 41 43 {ECO:0000244|PDB:3KYO}. FT STRAND 45 52 {ECO:0000244|PDB:3KYO}. FT STRAND 55 61 {ECO:0000244|PDB:3KYO}. FT STRAND 64 66 {ECO:0000244|PDB:3KYO}. FT STRAND 70 73 {ECO:0000244|PDB:2D31}. FT HELIX 74 76 {ECO:0000244|PDB:3KYO}. FT HELIX 81 108 {ECO:0000244|PDB:3KYO}. FT STRAND 113 115 {ECO:0000244|PDB:2DYP}. FT STRAND 118 132 {ECO:0000244|PDB:3KYO}. FT STRAND 134 142 {ECO:0000244|PDB:3KYO}. FT STRAND 145 150 {ECO:0000244|PDB:3KYO}. FT STRAND 157 161 {ECO:0000244|PDB:3KYO}. FT HELIX 162 173 {ECO:0000244|PDB:3KYO}. FT HELIX 176 185 {ECO:0000244|PDB:3KYO}. FT HELIX 187 198 {ECO:0000244|PDB:3KYO}. FT HELIX 200 203 {ECO:0000244|PDB:3KYO}. FT STRAND 210 218 {ECO:0000244|PDB:3KYO}. FT TURN 219 221 {ECO:0000244|PDB:3KYO}. FT STRAND 222 235 {ECO:0000244|PDB:3KYO}. FT STRAND 238 243 {ECO:0000244|PDB:3KYO}. FT STRAND 246 248 {ECO:0000244|PDB:3KYO}. FT HELIX 249 251 {ECO:0000244|PDB:1YDP}. FT STRAND 261 263 {ECO:0000244|PDB:3KYO}. FT STRAND 265 274 {ECO:0000244|PDB:3KYO}. FT HELIX 278 280 {ECO:0000244|PDB:3KYO}. FT STRAND 281 286 {ECO:0000244|PDB:3KYO}. FT STRAND 290 292 {ECO:0000244|PDB:3KYO}. FT STRAND 294 296 {ECO:0000244|PDB:3KYO}. SQ SEQUENCE 338 AA; 38224 MW; 0678E263BE8962FF CRC64; MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM NLQTLRGYYN QSEASSHTLQ WMIGCDLGSD GRLLRGYEQY AYDGKDYLAL NEDLRSWTAA DTAAQISKRK CEAANVAEQR RAYLEGTCVE WLHRYLENGK EMLQRADPPK THVTHHPVFD YEATLRCWAL GFYPAEIILT WQRDGEDQTQ DVELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLMLRWKQ SSLPTIPIMG IVAGLVVLAA VVTGAAVAAV LWRKKSSD // ID HLAG_PANTR Reviewed; 338 AA. AC Q95IT1; Q1XHW6; Q7YR28; DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 23-MAY-2018, entry version 94. DE RecName: Full=Patr class I histocompatibility antigen, alpha chain G; DE AltName: Full=MHC class I antigen G; DE Flags: Precursor; GN Name=Patr-G; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=11398964; DOI=10.1007/s002510100318; RA Adams E.J., Parham P.; RT "Genomic analysis of common chimpanzee major histocompatibility RT complex class I genes."; RL Immunogenetics 53:200-208(2001). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12799463; DOI=10.1073/pnas.1230533100; RA Anzai T., Shiina T., Kimura N., Yanagiya K., Kohara S., Shigenari A., RA Yamagata T., Kulski J.K., Naruse T.K., Fujimori Y., Fukuzumi Y., RA Yamazaki M., Tashiro H., Iwamoto C., Umehara Y., Imanishi T., RA Meyer A., Ikeo K., Gojobori T., Bahram S., Inoko H.; RT "Comparative sequencing of human and chimpanzee MHC class I regions RT unveils insertions/deletions as the major path to genomic RT divergence."; RL Proc. Natl. Acad. Sci. U.S.A. 100:7708-7713(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16702430; DOI=10.1534/genetics.106.057034; RA Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., RA Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., RA Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., RA Meyer A., Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., RA Gojobori T., Inoko H., Bahram S.; RT "Rapid evolution of major histocompatibility complex class I genes in RT primates generates new disease alleles in humans via hitchhiking RT diversity."; RL Genetics 173:1555-1570(2006). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000250}. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). Homodimer; disulfide-linked. Binds to LILRB1 and CC LILRB2. {ECO:0000250|UniProtKB:P17693}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass CC type I membrane protein {ECO:0000255}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AF338356; AAK77480.1; -; Genomic_DNA. DR EMBL; BA000041; BAC78190.1; -; Genomic_DNA. DR EMBL; AB210189; BAE92803.1; -; Genomic_DNA. DR EMBL; AB210190; BAE92804.1; -; Genomic_DNA. DR RefSeq; NP_001038977.1; NM_001045512.1. DR RefSeq; XP_016810228.1; XM_016954739.1. DR UniGene; Ptr.6339; -. DR UniGene; Ptr.6628; -. DR ProteinModelPortal; Q95IT1; -. DR SMR; Q95IT1; -. DR PRIDE; Q95IT1; -. DR Ensembl; ENSPTRT00000108079; ENSPTRP00000077334; ENSPTRG00000017908. DR GeneID; 494187; -. DR KEGG; ptr:494187; -. DR CTD; 494187; -. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; Q95IT1; -. DR KO; K06751; -. DR Proteomes; UP000002277; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000255}. FT CHAIN 25 338 Patr class I histocompatibility antigen, FT alpha chain G. FT /FTId=PRO_0000018887. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 338 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 299 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 66 66 Interchain. {ECO:0000255|PROSITE- FT ProRule:PRU00114}. FT DISULFID 125 188 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 338 AA; 38208 MW; 30193B7525BC9018 CRC64; MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG YVDDTQFVWF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRI NLQTLRGYYN QSEASSHTLQ WMIGCDLGSD GRLLRGYEQY AYDGKDYLAL NEDLRSWTAA DTAAQISKRK CEAANAAEQR RAYLEGTCVE WLHRYLENGK EMLQRADPPK THVTHHPVFD YEATLRCWAL GFYPAEIILT WQRDGEDQTQ DVELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLMLRWKQ SSLPTIPIMG IVAGLVVLAA VVTGAAVAAV LWRKKSSD // ID HLAH_HUMAN Reviewed; 362 AA. AC P01893; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 05-OCT-2010, sequence version 3. DT 20-JUN-2018, entry version 145. DE RecName: Full=Putative HLA class I histocompatibility antigen, alpha chain H; DE AltName: Full=HLA-12.4; DE AltName: Full=HLA-AR; DE AltName: Full=MHC class I antigen H; DE Flags: Precursor; GN Name=HLA-H; Synonyms=HLAH; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6461010; DOI=10.1073/pnas.79.3.893; RA Malissen M., Malissen B., Jordan B.R.; RT "Exon/intron organization and complete nucleotide sequence of an HLA RT gene."; RL Proc. Natl. Acad. Sci. U.S.A. 79:893-897(1982). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass CC membrane protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAA36218.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; J00191; AAA36218.1; ALT_INIT; Genomic_DNA. DR PIR; A02189; HLHU12. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR UniGene; Hs.728808; -. DR ProteinModelPortal; P01893; -. DR SMR; P01893; -. DR IntAct; P01893; 2. DR iPTMnet; P01893; -. DR SwissPalm; P01893; -. DR EPD; P01893; -. DR MaxQB; P01893; -. DR PeptideAtlas; P01893; -. DR PRIDE; P01893; -. DR ProteomicsDB; 51507; -. DR DisGeNET; 3136; -. DR GeneCards; HLA-H; -. DR HGNC; HGNC:4965; HLA-H. DR MIM; 142800; gene. DR neXtProt; NX_P01893; -. DR HOVERGEN; HBG016709; -. DR InParanoid; P01893; -. DR PhylomeDB; P01893; -. DR Reactome; R-HSA-1236974; ER-Phagosome pathway. DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-6798695; Neutrophil degranulation. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR ChiTaRS; HLA-H; human. DR PRO; PR:P01893; -. DR Proteomes; UP000005640; Unplaced. DR GO; GO:0035577; C:azurophil granule membrane; TAS:Reactome. DR GO; GO:0009986; C:cell surface; IMP:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome. DR GO; GO:0030881; F:beta-2-microglobulin binding; IMP:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. DR GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. DR GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 5: Uncertain; KW Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; MHC I; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000255}. FT CHAIN 25 362 Putative HLA class I histocompatibility FT antigen, alpha chain H. FT /FTId=PRO_0000018888. FT TOPO_DOM 25 308 Extracellular. {ECO:0000255}. FT TRANSMEM 309 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}. FT DOMAIN 209 297 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000250}. FT DISULFID 227 283 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 362 AA; 40892 MW; 8ADFD2388FEC4645 CRC64; MVLMAPRTLL LLLSGALALT QTWARSHSMR YFYTTMSRPG AGEPRFISVG YVDDTQFVRF DSDDASPREE PRAPWMEREG PKYWDRNTQI CKAQAQTERE NLRIALRYYN QSEGGSHTMQ VMYGCDVGPD GPFLRGYEQH AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAARRAEQR RVYLEGEFVE WLRRYLENGK ETLQRADPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTVPIVG IVAGLVLLVA VVTGAVVAAV MWRKKSSDRK GGSYSQAASS NSAQGSDVSL TA // ID HMR1_BOVIN Reviewed; 336 AA. AC C1ITJ8; F1MVL8; DT 19-FEB-2014, integrated into UniProtKB/Swiss-Prot. DT 26-MAY-2009, sequence version 1. DT 12-SEP-2018, entry version 71. DE RecName: Full=Major histocompatibility complex class I-related gene protein; DE Short=MHC class I-related gene protein; DE AltName: Full=Class I histocompatibility antigen-like protein; DE Flags: Precursor; GN Name=MR1; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBUNIT. RX PubMed=19416870; DOI=10.1073/pnas.0903196106; RA Huang S., Martin E., Kim S., Yu L., Soudais C., Fremont D.H., RA Lantz O., Hansen T.H.; RT "MR1 antigen presentation to mucosal-associated invariant T cells was RT highly conserved in evolution."; RL Proc. Natl. Acad. Sci. U.S.A. 106:8290-8295(2009). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Van Rhijn I.; RT "Ruminant MR1 and MAIT cells."; RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [4] RP X-RAY CRYSTALLOGRAPHY (2.86 ANGSTROMS) OF 19-295 IN COMPLEX WITH B2M RP AND HUMAN T-CELL RECEPTOR, AND DISULFIDE BONDS. RX PubMed=23613577; DOI=10.1073/pnas.1222678110; RA Lopez-Sagaseta J., Dulberger C.L., Crooks J.E., Parks C.D., RA Luoma A.M., McFedries A., Van Rhijn I., Saghatelian A., Adams E.J.; RT "The molecular basis for Mucosal-Associated Invariant T cell RT recognition of MR1 proteins."; RL Proc. Natl. Acad. Sci. U.S.A. 110:E1771-E1778(2013). CC -!- FUNCTION: Antigen-presenting molecule specialized in presenting CC microbial vitamin B metabolites (By similarity). Involved in the CC development and expansion of a small population of T-cells CC expressing an invariant T-cell receptor alpha chain called CC mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are CC preferentially located in the gut lamina propria and therefore may CC be involved in monitoring commensal flora or serve as a distress CC signal. Expression and MAIT cell recognition seem to be ligand- CC dependent. {ECO:0000250, ECO:0000269|PubMed:19416870}. CC -!- SUBUNIT: Heterodimerizes with B2M, this interaction is required CC for surface expression. Associated with the peptide-loading CC complex, TAPBP, CALR and PDIA3. {ECO:0000269|PubMed:19416870, CC ECO:0000269|PubMed:23613577}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass CC type I membrane protein {ECO:0000250}; Extracellular side CC {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. CC -!- DOMAIN: The alpha-3 region and to a lesser extent the CC transmembrane and cytosolic domains regulate surface expression CC (By similarity). The alpha-3 region mediates interaction with B2M. CC {ECO:0000250}. CC -!- DOMAIN: The ligand-binding groove is ideally suited to present CC small organic compounds that can originate from vitamins rather CC than antigenic peptides. {ECO:0000250}. CC -!- PTM: N-glycosylated. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; EU792881; ACH56827.1; -; mRNA. DR EMBL; FJ028657; ACN18277.1; -; mRNA. DR EMBL; DAAA02043522; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DAAA02043523; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001177227.1; NM_001190298.1. DR UniGene; Bt.63045; -. DR PDB; 4IIQ; X-ray; 2.86 A; C=19-295. DR PDB; 4L8S; X-ray; 2.90 A; C=19-295. DR PDB; 4L9L; X-ray; 3.40 A; C=19-295. DR PDB; 4LCC; X-ray; 3.26 A; C=19-295. DR PDBsum; 4IIQ; -. DR PDBsum; 4L8S; -. DR PDBsum; 4L9L; -. DR PDBsum; 4LCC; -. DR ProteinModelPortal; C1ITJ8; -. DR SMR; C1ITJ8; -. DR STRING; 9913.ENSBTAP00000013095; -. DR PaxDb; C1ITJ8; -. DR PRIDE; C1ITJ8; -. DR Ensembl; ENSBTAT00000013095; ENSBTAP00000013095; ENSBTAG00000009924. DR GeneID; 506206; -. DR KEGG; bta:506206; -. DR CTD; 3140; -. DR VGNC; VGNC:31595; MR1. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR InParanoid; C1ITJ8; -. DR OMA; GYVDSHP; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000009136; Chromosome 16. DR Bgee; ENSBTAG00000009924; Expressed in 10 organ(s), highest expression level in spleen. DR ExpressionAtlas; C1ITJ8; baseline and differential. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Cell membrane; Complete proteome; Disulfide bond; KW Endoplasmic reticulum; Glycoprotein; Immunity; Immunoglobulin domain; KW Innate immunity; Membrane; MHC I; Reference proteome; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1 18 {ECO:0000250}. FT CHAIN 19 336 Major histocompatibility complex class I- FT related gene protein. FT /FTId=PRO_0000425531. FT TOPO_DOM 19 298 Extracellular. {ECO:0000255}. FT TRANSMEM 299 319 Helical. {ECO:0000255}. FT TOPO_DOM 320 336 Cytoplasmic. {ECO:0000255}. FT DOMAIN 199 295 Ig-like C1-type. FT REGION 19 197 Ligand-binding. {ECO:0000250}. FT REGION 19 105 Alpha-1. FT REGION 106 197 Alpha-2. FT REGION 198 289 Alpha-3. FT REGION 290 298 Connecting peptide. {ECO:0000250}. FT BINDING 61 61 Pathogen-derived ligand. {ECO:0000250}. FT CARBOHYD 103 103 N-linked (GlcNAc...) asparagine. FT {ECO:0000305}. FT DISULFID 116 179 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:23613577}. FT DISULFID 218 274 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:23613577}. FT STRAND 21 30 {ECO:0000244|PDB:4IIQ}. FT STRAND 39 46 {ECO:0000244|PDB:4IIQ}. FT STRAND 49 58 {ECO:0000244|PDB:4IIQ}. FT STRAND 63 65 {ECO:0000244|PDB:4IIQ}. FT HELIX 66 69 {ECO:0000244|PDB:4IIQ}. FT HELIX 74 101 {ECO:0000244|PDB:4IIQ}. FT STRAND 109 118 {ECO:0000244|PDB:4IIQ}. FT STRAND 120 122 {ECO:0000244|PDB:4IIQ}. FT STRAND 124 132 {ECO:0000244|PDB:4IIQ}. FT STRAND 135 141 {ECO:0000244|PDB:4IIQ}. FT TURN 142 145 {ECO:0000244|PDB:4IIQ}. FT STRAND 146 153 {ECO:0000244|PDB:4IIQ}. FT HELIX 154 163 {ECO:0000244|PDB:4IIQ}. FT HELIX 165 176 {ECO:0000244|PDB:4IIQ}. FT HELIX 178 189 {ECO:0000244|PDB:4IIQ}. FT HELIX 191 194 {ECO:0000244|PDB:4IIQ}. FT STRAND 201 206 {ECO:0000244|PDB:4IIQ}. FT STRAND 215 226 {ECO:0000244|PDB:4IIQ}. FT STRAND 229 234 {ECO:0000244|PDB:4IIQ}. FT STRAND 241 245 {ECO:0000244|PDB:4L8S}. FT STRAND 252 254 {ECO:0000244|PDB:4IIQ}. FT STRAND 256 263 {ECO:0000244|PDB:4IIQ}. FT STRAND 272 280 {ECO:0000244|PDB:4IIQ}. FT STRAND 282 288 {ECO:0000244|PDB:4IIQ}. SQ SEQUENCE 336 AA; 38894 MW; D0501CC96F59A2C1 CRC64; MMLLLPLIIV LMMKLSDART HSLRYFRLGI SEPGYGIPEF ISAGYVDSHP ITMYNSVSQL KEPRALWMEE NLAPDHWERY TQLLRGWQQA FKVELKQLQH HYNHSGFHTY QRMIGCELLE DGSITGFLQY AYDGQDFLIF NKDTLSWMAM DNVADIIRRV WEANRHELQY QKNWLEEECI AWLKRFLEYG KDALQRTEPP KVRVNHKETF PGITTLYCRA YGFYPPEISI NWMKNGEEIF QDTDYGGILP SGDGTYQTWV SVELDPQNGD IYSCHVEHGG VHMVLQGFQE SETILLVVKA VGFIVLAIAL AGVGILAWRK RPRGKNKVIC LSTPEH // ID HMR1_HUMAN Reviewed; 341 AA. AC Q95460; A8K2V9; B4E3B1; O97985; O97986; Q53GM1; Q95HB8; Q9MY23; AC Q9NPL2; Q9TQB3; Q9TQB9; Q9TQK3; DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 12-SEP-2018, entry version 161. DE RecName: Full=Major histocompatibility complex class I-related gene protein; DE Short=MHC class I-related gene protein; DE AltName: Full=Class I histocompatibility antigen-like protein; DE Flags: Precursor; GN Name=MR1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND RP TOPOLOGY. RC TISSUE=Thymus; RX PubMed=7624800; DOI=10.1126/science.7624800; RA Hashimoto K., Hirai M., Kurosawa Y.; RT "A gene outside the human MHC related to classical HLA class I RT genes."; RL Science 269:693-695(1995). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND POLYMORPHISM. RC TISSUE=Peripheral blood; RX PubMed=11019920; DOI=10.1034/j.1399-0039.2000.560211.x; RA Parra-Cuadrado J.F., Navarro P., Mirones I., Setien F., Oteo M., RA Martinez-Naves E.; RT "A study on the polymorphism of human MHC class I-related MR1 gene and RT identification of an MR1-like pseudogene."; RL Tissue Antigens 56:170-172(2000). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5). RC TISSUE=Tongue, and Uterus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Kidney proximal tubule; RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., RA Tanaka A., Yokoyama S.; RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., RA Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11, NUCLEOTIDE SEQUENCE [MRNA] RP OF 5-341 (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 6-229 (ISOFORM 4), RP TOPOLOGY, AND ALTERNATIVE SPLICING. RX PubMed=9780177; RA Riegert P., Wanner V., Bahram S.; RT "Genomics, isoforms, expression, and phylogeny of the MHC class I- RT related MR1 gene."; RL J. Immunol. 161:4066-4077(1998). RN [9] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-341. RC TISSUE=Placenta; RX PubMed=9784382; DOI=10.1006/bbrc.1998.9353; RA Yamaguchi H., Kurosawa Y., Hashimoto K.; RT "Expanded genomic organization of conserved mammalian MHC class I- RT related genes, human MR1 and its murine ortholog."; RL Biochem. Biophys. Res. Commun. 250:558-564(1998). RN [10] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-109, AND VARIANT ARG-39. RA Han M., Robinson M.A.; RT "Unrelated expression patterns of MHC class Ia, Ib and TCRA RT molecules."; RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases. RN [11] RP FUNCTION, SUBCELLULAR LOCATION, SIGNAL SEQUENCE CLEAVAGE SITE, RP GLYCOSYLATION AT ASN-107, INTERACTION WITH B2M; TAPBP; CALR AND PDIA3, RP AND MUTAGENESIS OF CYS-283. RX PubMed=12794138; DOI=10.4049/jimmunol.170.12.6090; RA Miley M.J., Truscott S.M., Yu Y.Y., Gilfillan S., Fremont D.H., RA Hansen T.H., Lybarger L.; RT "Biochemical features of the MHC-related protein 1 consistent with an RT immunological function."; RL J. Immunol. 170:6090-6098(2003). RN [12] RP SUBCELLULAR LOCATION, AND INTERACTION WITH B2M. RX PubMed=18068122; DOI=10.1016/j.bbrc.2007.11.156; RA Aldemir H.; RT "Novel MHC class I-related molecule MR1 affects MHC class I expression RT in 293T cells."; RL Biochem. Biophys. Res. Commun. 366:328-334(2008). RN [13] RP FUNCTION, AND MUTAGENESIS OF GLN-169. RX PubMed=19416870; DOI=10.1073/pnas.0903196106; RA Huang S., Martin E., Kim S., Yu L., Soudais C., Fremont D.H., RA Lantz O., Hansen T.H.; RT "MR1 antigen presentation to mucosal-associated invariant T cells was RT highly conserved in evolution."; RL Proc. Natl. Acad. Sci. U.S.A. 106:8290-8295(2009). RN [14] RP SUBCELLULAR LOCATION (ISOFORM 3), AND SUBUNIT (ISOFORM 3). RX PubMed=23457030; DOI=10.1002/eji.201242461; RA Lion J., Debuysscher V., Wlodarczyk A., Hodroge A., Serriari N.E., RA Choteau L., Ouled-haddou H., Plistat M., Lassoued K., Lantz O., RA Treiner E.; RT "MR1B, a natural spliced isoform of the MHC-related 1 protein, is RT expressed as homodimers at the cell surface and activates MAIT RT cells."; RL Eur. J. Immunol. 43:1363-1373(2013). RN [15] RP X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 23-292 IN COMPLEX WITH RP VITAMIN B9 METABOLITE, LIGAND-BINDING SITES, AND DISULFIDE BONDS. RX PubMed=23051753; DOI=10.1038/nature11605; RA Kjer-Nielsen L., Patel O., Corbett A.J., Le Nours J., Meehan B., RA Liu L., Bhati M., Chen Z., Kostenko L., Reantragoon R., RA Williamson N.A., Purcell A.W., Dudek N.L., McConville M.J., RA O'Hair R.A., Khairallah G.N., Godfrey D.I., Fairlie D.P., Rossjohn J., RA McCluskey J.; RT "MR1 presents microbial vitamin B metabolites to MAIT cells."; RL Nature 491:717-723(2012). CC -!- FUNCTION: Antigen-presenting molecule specialized in presenting CC microbial vitamin B metabolites. Involved in the development and CC expansion of a small population of T-cells expressing an invariant CC T-cell receptor alpha chain called mucosal-associated invariant T- CC cells (MAIT). MAIT lymphocytes are preferentially located in the CC gut lamina propria and therefore may be involved in monitoring CC commensal flora or serve as a distress signal. Expression and MAIT CC cell recognition seem to be ligand-dependent. CC {ECO:0000269|PubMed:12794138, ECO:0000269|PubMed:19416870}. CC -!- SUBUNIT: Heterodimerizes with B2M, this interaction is required CC for surface expression. Associated with the peptide-loading CC complex, TAPBP, CALR and PDIA3. Isoform 3/MR1B homodimerizes and CC doesn't associates with B2M nor proteins of the peptide-loading CC complex. {ECO:0000269|PubMed:23051753}. CC -!- INTERACTION: CC P61769:B2M; NbExp=3; IntAct=EBI-16016814, EBI-714718; CC Q969F0:FATE1; NbExp=3; IntAct=EBI-10280401, EBI-743099; CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein; CC Extracellular side. Endoplasmic reticulum. CC -!- SUBCELLULAR LOCATION: Isoform 4: Secreted. CC -!- SUBCELLULAR LOCATION: Isoform 3: Cell membrane CC {ECO:0000269|PubMed:23457030}; Single-pass type I membrane protein CC {ECO:0000269|PubMed:23457030}. Endoplasmic reticulum membrane CC {ECO:0000269|PubMed:23457030}. Note=The larger proportion remains CC in the ER in an immature state. The subset that reach cell surface CC does it through a B2M-independent pathway. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=1; Synonyms=MR1A; CC IsoId=Q95460-1; Sequence=Displayed; CC Name=2; CC IsoId=Q95460-2; Sequence=VSP_034755; CC Name=3; Synonyms=MR1B, MR1D; CC IsoId=Q95460-3; Sequence=VSP_034757; CC Name=4; Synonyms=MR1C; CC IsoId=Q95460-4; Sequence=VSP_034756, VSP_034758; CC Name=5; CC IsoId=Q95460-5; Sequence=VSP_043479; CC Note=No experimental confirmation available.; CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:7624800}. CC -!- DOMAIN: The alpha-3 region and to a lesser extent the CC transmembrane and cytosolic domains regulate surface expression. CC The alpha-3 region mediates interaction with B2M CC (PubMed:23051753). {ECO:0000269|PubMed:23051753}. CC -!- DOMAIN: The ligand-binding groove is ideally suited to present CC small organic compounds that can originate from vitamins rather CC than antigenic peptides. {ECO:0000269|PubMed:23051753}. CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:12794138}. CC -!- POLYMORPHISM: Several individuals from different ethnic background CC were analyzed for polymorphism. MR1 was identical in all CC individuals analyzed, except one. MR1 is not polymorphic. CC -!- MISCELLANEOUS: MR1 is detected in an open versus folded CC conformation. Only the folded MR1 conformer activates MAIT cells. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAD01443.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; U22963; AAC50174.1; -; mRNA. DR EMBL; AJ249778; CAB77667.1; -; mRNA. DR EMBL; AK290374; BAF83063.1; -; mRNA. DR EMBL; AK304645; BAG65423.1; -; mRNA. DR EMBL; AK222910; BAD96630.1; -; mRNA. DR EMBL; AL356267; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471067; EAW91097.1; -; Genomic_DNA. DR EMBL; CH471067; EAW91098.1; -; Genomic_DNA. DR EMBL; CH471067; EAW91095.1; -; Genomic_DNA. DR EMBL; BC012485; AAH12485.1; -; mRNA. DR EMBL; AF010446; AAD01442.1; -; mRNA. DR EMBL; AF010447; AAD01443.1; ALT_INIT; mRNA. DR EMBL; AF031469; AAD01933.1; -; mRNA. DR EMBL; AF039526; AAD02172.1; -; Genomic_DNA. DR EMBL; AH006983; AAC72900.1; -; Genomic_DNA. DR EMBL; AF223407; AAF40170.1; -; Genomic_DNA. DR CCDS; CCDS1342.1; -. [Q95460-1] DR CCDS; CCDS53440.1; -. [Q95460-3] DR CCDS; CCDS53441.1; -. [Q95460-5] DR CCDS; CCDS53442.1; -. [Q95460-2] DR PIR; A57136; A57136. DR RefSeq; NP_001181928.1; NM_001194999.1. [Q95460-2] DR RefSeq; NP_001181929.1; NM_001195000.1. [Q95460-3] DR RefSeq; NP_001181964.1; NM_001195035.1. [Q95460-5] DR RefSeq; NP_001522.1; NM_001531.2. [Q95460-1] DR UniGene; Hs.13500; -. DR PDB; 4GUP; X-ray; 3.20 A; A/C=23-292. DR PDB; 4L4T; X-ray; 2.00 A; A/C=23-292. DR PDB; 4L4V; X-ray; 1.90 A; A/C=23-292. DR PDB; 4LCW; X-ray; 2.40 A; A/C=23-292. DR PDB; 4NQC; X-ray; 2.50 A; A/C=23-292. DR PDB; 4NQD; X-ray; 2.20 A; A/C=23-292. DR PDB; 4NQE; X-ray; 2.10 A; A/C=23-292. DR PDB; 4PJ5; X-ray; 2.00 A; A/C=23-292. DR PDB; 4PJ7; X-ray; 2.50 A; A/C=23-292. DR PDB; 4PJ8; X-ray; 3.30 A; A=23-292. DR PDB; 4PJ9; X-ray; 2.00 A; A=23-292. DR PDB; 4PJA; X-ray; 2.68 A; A/C=23-292. DR PDB; 4PJB; X-ray; 2.85 A; A/C=23-292. DR PDB; 4PJC; X-ray; 2.50 A; A/C=23-292. DR PDB; 4PJD; X-ray; 2.78 A; A/C=23-292. DR PDB; 4PJE; X-ray; 1.95 A; A/C=23-292. DR PDB; 4PJF; X-ray; 2.45 A; A/C=23-292. DR PDB; 4PJG; X-ray; 2.40 A; A/C=23-292. DR PDB; 4PJH; X-ray; 2.00 A; A/C=23-292. DR PDB; 4PJI; X-ray; 2.50 A; A/C=23-292. DR PDB; 4PJX; X-ray; 2.25 A; A/C=23-292. DR PDB; 5D5M; X-ray; 2.20 A; A/C=23-292. DR PDB; 5D7I; X-ray; 2.00 A; A/C=23-292. DR PDB; 5D7J; X-ray; 1.97 A; C/E=23-292. DR PDB; 5D7L; X-ray; 3.40 A; A/C=23-292. DR PDB; 5U16; X-ray; 2.00 A; A/C=23-292. DR PDB; 5U17; X-ray; 2.15 A; A/C=23-292. DR PDB; 5U1R; X-ray; 2.70 A; A/C=23-292. DR PDB; 5U2V; X-ray; 2.20 A; A/C=23-292. DR PDB; 5U6Q; X-ray; 1.90 A; A/C=23-292. DR PDB; 5U72; X-ray; 2.50 A; A/C=23-292. DR PDBsum; 4GUP; -. DR PDBsum; 4L4T; -. DR PDBsum; 4L4V; -. DR PDBsum; 4LCW; -. DR PDBsum; 4NQC; -. DR PDBsum; 4NQD; -. DR PDBsum; 4NQE; -. DR PDBsum; 4PJ5; -. DR PDBsum; 4PJ7; -. DR PDBsum; 4PJ8; -. DR PDBsum; 4PJ9; -. DR PDBsum; 4PJA; -. DR PDBsum; 4PJB; -. DR PDBsum; 4PJC; -. DR PDBsum; 4PJD; -. DR PDBsum; 4PJE; -. DR PDBsum; 4PJF; -. DR PDBsum; 4PJG; -. DR PDBsum; 4PJH; -. DR PDBsum; 4PJI; -. DR PDBsum; 4PJX; -. DR PDBsum; 5D5M; -. DR PDBsum; 5D7I; -. DR PDBsum; 5D7J; -. DR PDBsum; 5D7L; -. DR PDBsum; 5U16; -. DR PDBsum; 5U17; -. DR PDBsum; 5U1R; -. DR PDBsum; 5U2V; -. DR PDBsum; 5U6Q; -. DR PDBsum; 5U72; -. DR ProteinModelPortal; Q95460; -. DR SMR; Q95460; -. DR BioGrid; 109385; 23. DR DIP; DIP-59986N; -. DR IntAct; Q95460; 8. DR STRING; 9606.ENSP00000356552; -. DR DrugBank; DB00098; Anti-thymocyte Globulin (Rabbit). DR iPTMnet; Q95460; -. DR PhosphoSitePlus; Q95460; -. DR BioMuta; MR1; -. DR DMDM; 74751679; -. DR EPD; Q95460; -. DR PaxDb; Q95460; -. DR PeptideAtlas; Q95460; -. DR PRIDE; Q95460; -. DR ProteomicsDB; 75731; -. DR ProteomicsDB; 75732; -. [Q95460-2] DR ProteomicsDB; 75733; -. [Q95460-3] DR ProteomicsDB; 75734; -. [Q95460-4] DR ProteomicsDB; 75735; -. [Q95460-5] DR Ensembl; ENST00000282990; ENSP00000282990; ENSG00000153029. [Q95460-3] DR Ensembl; ENST00000367579; ENSP00000356551; ENSG00000153029. [Q95460-2] DR Ensembl; ENST00000367580; ENSP00000356552; ENSG00000153029. [Q95460-1] DR Ensembl; ENST00000434571; ENSP00000388504; ENSG00000153029. [Q95460-5] DR Ensembl; ENST00000614012; ENSP00000477563; ENSG00000153029. [Q95460-1] DR Ensembl; ENST00000617803; ENSP00000478976; ENSG00000153029. [Q95460-3] DR GeneID; 3140; -. DR KEGG; hsa:3140; -. DR UCSC; uc001goq.2; human. [Q95460-1] DR CTD; 3140; -. DR DisGeNET; 3140; -. DR EuPathDB; HostDB:ENSG00000153029.14; -. DR GeneCards; MR1; -. DR HGNC; HGNC:4975; MR1. DR HPA; HPA048304; -. DR MalaCards; MR1; -. DR MIM; 600764; gene. DR neXtProt; NX_Q95460; -. DR OpenTargets; ENSG00000153029; -. DR PharmGKB; PA29309; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; Q95460; -. DR OMA; GYVDSHP; -. DR OrthoDB; EOG091G0K1X; -. DR PhylomeDB; Q95460; -. DR TreeFam; TF336617; -. DR ChiTaRS; MR1; human. DR GeneWiki; Major_histocompatibility_complex,_class_I-related; -. DR GenomeRNAi; 3140; -. DR PRO; PR:Q95460; -. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; ENSG00000153029; Expressed in 217 organ(s), highest expression level in lymph node. DR CleanEx; HS_MR1; -. DR Genevisible; Q95460; HS. DR GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IDA:HPA. DR GO; GO:0032393; F:MHC class I receptor activity; TAS:UniProtKB. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0006955; P:immune response; TAS:ProtInc. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Cell membrane; Complete proteome; KW Disulfide bond; Endoplasmic reticulum; Glycoprotein; Immunity; KW Immunoglobulin domain; Innate immunity; Membrane; MHC I; Polymorphism; KW Reference proteome; Secreted; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 22 {ECO:0000269|PubMed:12794138}. FT CHAIN 23 341 Major histocompatibility complex class I- FT related gene protein. FT /FTId=PRO_0000344441. FT TOPO_DOM 23 302 Extracellular. {ECO:0000255}. FT TRANSMEM 303 323 Helical. {ECO:0000255}. FT TOPO_DOM 324 341 Cytoplasmic. {ECO:0000255}. FT DOMAIN 203 299 Ig-like C1-type. FT REGION 23 201 Ligand-binding. FT REGION 23 109 Alpha-1. FT REGION 110 201 Alpha-2. FT REGION 202 293 Alpha-3. FT REGION 294 302 Connecting peptide. FT BINDING 65 65 Pathogen-derived ligand. FT CARBOHYD 107 107 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:12794138}. FT DISULFID 120 183 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:23051753}. FT DISULFID 222 278 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:23051753}. FT VAR_SEQ 110 154 Missing (in isoform 2). FT {ECO:0000303|PubMed:15489334}. FT /FTId=VSP_034755. FT VAR_SEQ 202 328 Missing (in isoform 5). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_043479. FT VAR_SEQ 202 220 EPPLVRVNRKETFPGVTAL -> GKEKEKASFPHCLNNCFY FT T (in isoform 4). FT {ECO:0000303|PubMed:9780177}. FT /FTId=VSP_034756. FT VAR_SEQ 203 294 Missing (in isoform 3). FT {ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:9780177}. FT /FTId=VSP_034757. FT VAR_SEQ 221 341 Missing (in isoform 4). FT {ECO:0000303|PubMed:9780177}. FT /FTId=VSP_034758. FT VARIANT 39 39 H -> R (in dbSNP:rs2236410). FT {ECO:0000269|Ref.10}. FT /FTId=VAR_045608. FT VARIANT 63 63 R -> Q (in dbSNP:rs3897433). FT /FTId=VAR_045609. FT VARIANT 77 77 A -> V (in dbSNP:rs3897434). FT /FTId=VAR_045610. FT MUTAGEN 65 65 K->R: Fails to refold in the presence of FT 6-FP. FT MUTAGEN 169 169 Q->L: Able to activate mouse MAIT cells. FT {ECO:0000269|PubMed:19416870}. FT MUTAGEN 283 283 C->G: No effect on cell surface FT expression. FT {ECO:0000269|PubMed:12794138}. FT CONFLICT 117 117 M -> V (in Ref. 3; BAF83063). FT {ECO:0000305}. FT CONFLICT 200 200 R -> G (in Ref. 4; BAD96630). FT {ECO:0000305}. FT CONFLICT 315 315 L -> P (in Ref. 4; BAD96630). FT {ECO:0000305}. FT STRAND 25 36 {ECO:0000244|PDB:4L4V}. FT STRAND 39 41 {ECO:0000244|PDB:5D7J}. FT STRAND 43 50 {ECO:0000244|PDB:4L4V}. FT STRAND 53 59 {ECO:0000244|PDB:4L4V}. FT TURN 60 62 {ECO:0000244|PDB:4L4V}. FT STRAND 66 69 {ECO:0000244|PDB:4L4V}. FT HELIX 70 73 {ECO:0000244|PDB:4L4V}. FT STRAND 74 76 {ECO:0000244|PDB:5D7L}. FT HELIX 78 106 {ECO:0000244|PDB:4L4V}. FT STRAND 113 122 {ECO:0000244|PDB:4L4V}. FT STRAND 128 136 {ECO:0000244|PDB:4L4V}. FT STRAND 139 145 {ECO:0000244|PDB:4L4V}. FT TURN 146 149 {ECO:0000244|PDB:4L4V}. FT STRAND 150 155 {ECO:0000244|PDB:4L4V}. FT HELIX 156 166 {ECO:0000244|PDB:4L4V}. FT HELIX 169 180 {ECO:0000244|PDB:4L4V}. FT HELIX 182 193 {ECO:0000244|PDB:4L4V}. FT HELIX 195 198 {ECO:0000244|PDB:4L4V}. FT STRAND 205 212 {ECO:0000244|PDB:4L4V}. FT STRAND 214 216 {ECO:0000244|PDB:4PJB}. FT STRAND 218 230 {ECO:0000244|PDB:4L4V}. FT STRAND 233 238 {ECO:0000244|PDB:4L4V}. FT TURN 239 241 {ECO:0000244|PDB:4PJ9}. FT HELIX 244 246 {ECO:0000244|PDB:5U6Q}. FT STRAND 247 249 {ECO:0000244|PDB:5U6Q}. FT STRAND 256 258 {ECO:0000244|PDB:4L4V}. FT STRAND 260 267 {ECO:0000244|PDB:4L4V}. FT STRAND 270 272 {ECO:0000244|PDB:4PJ5}. FT STRAND 276 282 {ECO:0000244|PDB:4L4V}. FT STRAND 285 290 {ECO:0000244|PDB:4L4V}. SQ SEQUENCE 341 AA; 39366 MW; 2990C1F3F0A1CAD9 CRC64; MGELMAFLLP LIIVLMVKHS DSRTHSLRYF RLGVSDPIHG VPEFISVGYV DSHPITTYDS VTRQKEPRAP WMAENLAPDH WERYTQLLRG WQQMFKVELK RLQRHYNHSG SHTYQRMIGC ELLEDGSTTG FLQYAYDGQD FLIFNKDTLS WLAVDNVAHT IKQAWEANQH ELLYQKNWLE EECIAWLKRF LEYGKDTLQR TEPPLVRVNR KETFPGVTAL FCKAHGFYPP EIYMTWMKNG EEIVQEIDYG DILPSGDGTY QAWASIELDP QSSNLYSCHV EHCGVHMVLQ VPQESETIPL VMKAVSGSIV LVIVLAGVGV LVWRRRPREQ NGAIYLPTPD R // ID HMR1_MOUSE Reviewed; 341 AA. AC Q8HWB0; O19478; DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot. DT 22-JUL-2008, sequence version 2. DT 12-SEP-2018, entry version 123. DE RecName: Full=Major histocompatibility complex class I-related gene protein; DE Short=MHC class I-related gene protein; DE AltName: Full=Class I histocompatibility antigen-like protein; DE Flags: Precursor; GN Name=Mr1; Synonyms=Mr1a; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), AND TISSUE RP SPECIFICITY. RC STRAIN=BALB/cJ; TISSUE=Lung; RX PubMed=9325151; DOI=10.1006/bbrc.1997.7379; RA Yamaguchi H., Hirai M., Kurosawa Y., Hashimoto K.; RT "A highly conserved major histocompatibility complex class I-related RT gene in mammals."; RL Biochem. Biophys. Res. Commun. 238:697-702(1997). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), ALTERNATIVE RP SPLICING, AND TISSUE SPECIFICITY. RC STRAIN=C57BL/6J, and C57BL/6J X 129/SvJ; TISSUE=Spleen; RX PubMed=9780177; RA Riegert P., Wanner V., Bahram S.; RT "Genomics, isoforms, expression, and phylogeny of the MHC class I- RT related MR1 gene."; RL J. Immunol. 161:4066-4077(1998). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC STRAIN=C57BL/6J; TISSUE=Thymus; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC STRAIN=Czech II; TISSUE=Mammary tumor; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP INTERACTION WITH B2M. RX PubMed=11785959; DOI=10.1006/bbrc.2001.6277; RA Yamaguchi H., Hashimoto K.; RT "Association of MR1 protein, an MHC class I-related molecule, with RT beta(2)-microglobulin."; RL Biochem. Biophys. Res. Commun. 290:722-729(2002). RN [6] RP TISSUE SPECIFICITY, INTERACTION WITH B2M; TAPBP; CALR AND PDIA3, AND RP MUTAGENESIS OF CYS-279. RX PubMed=12794138; DOI=10.4049/jimmunol.170.12.6090; RA Miley M.J., Truscott S.M., Yu Y.Y., Gilfillan S., Fremont D.H., RA Hansen T.H., Lybarger L.; RT "Biochemical features of the MHC-related protein 1 consistent with an RT immunological function."; RL J. Immunol. 170:6090-6098(2003). RN [7] RP FUNCTION, AND MUTAGENESIS OF TYR-25; ARG-27; PHE-40; LEU-83; GLY-86; RP LYS-92; ALA-93; GLN-99; TYR-110; ARG-112; LEU-128; TYR-170 AND RP ALA-181. RX PubMed=15802267; DOI=10.1074/jbc.M501087200; RA Huang S., Gilfillan S., Cella M., Miley M.J., Lantz O., Lybarger L., RA Fremont D.H., Hansen T.H.; RT "Evidence for MR1 antigen presentation to mucosal-associated invariant RT T cells."; RL J. Biol. Chem. 280:21183-21193(2005). CC -!- FUNCTION: Antigen-presenting molecule specialized in presenting CC microbial vitamin B metabolites (By similarity). Involved in the CC development and expansion of a small population of T-cells CC expressing an invariant T-cell receptor alpha chain called CC mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are CC preferentially located in the gut lamina propria and therefore may CC be involved in monitoring commensal flora or serve as a distress CC signal. Expression and MAIT cell recognition seem to be ligand- CC dependent. {ECO:0000250, ECO:0000269|PubMed:15802267}. CC -!- SUBUNIT: Heterodimerizes with B2M, this interaction is required CC for surface expression. Associated with the peptide-loading CC complex, TAPBP, CALR and PDIA3. CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane CC protein. Endoplasmic reticulum {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; Synonyms=Mr1a; CC IsoId=Q8HWB0-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8HWB0-2; Sequence=VSP_034759; CC Note=No experimental confirmation available.; CC -!- TISSUE SPECIFICITY: Highly expressed thymus. Expressed in liver, CC kidney, spleen, heart, brain, lung, skeletal muscle and testis. CC {ECO:0000269|PubMed:12794138, ECO:0000269|PubMed:9325151, CC ECO:0000269|PubMed:9780177}. CC -!- DOMAIN: The alpha-3 region and to a lesser extent the CC transmembrane and cytosolic domains regulate surface expression. CC The alpha-3 region mediates interaction with B2M. CC -!- DOMAIN: The ligand-binding groove is ideally suited to present CC small organic compounds that can originate from vitamins rather CC than antigenic peptides. {ECO:0000250}. CC -!- PTM: N-glycosylated. {ECO:0000250}. CC -!- MISCELLANEOUS: MR1 is detected in an open versus folded CC conformation. Only the folded MR1 conformer activates MAIT cells. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; U94989; AAB81345.1; -; mRNA. DR EMBL; AF068692; AAD17568.1; -; Genomic_DNA. DR EMBL; AF068691; AAD17568.1; JOINED; Genomic_DNA. DR EMBL; AF010448; AAD01444.1; -; mRNA. DR EMBL; AF035672; AAD02040.1; -; Genomic_DNA. DR EMBL; AK042119; BAC31174.1; -; mRNA. DR EMBL; BC026137; AAH26137.1; -; mRNA. DR CCDS; CCDS15383.1; -. [Q8HWB0-1] DR PIR; JC5663; JC5663. DR RefSeq; NP_032235.1; NM_008209.4. [Q8HWB0-1] DR RefSeq; XP_006529207.1; XM_006529144.2. DR UniGene; Mm.7580; -. DR ProteinModelPortal; Q8HWB0; -. DR SMR; Q8HWB0; -. DR STRING; 10090.ENSMUSP00000027744; -. DR PhosphoSitePlus; Q8HWB0; -. DR PaxDb; Q8HWB0; -. DR PeptideAtlas; Q8HWB0; -. DR PRIDE; Q8HWB0; -. DR Ensembl; ENSMUST00000027744; ENSMUSP00000027744; ENSMUSG00000026471. [Q8HWB0-1] DR GeneID; 15064; -. DR KEGG; mmu:15064; -. DR UCSC; uc007day.1; mouse. [Q8HWB0-1] DR CTD; 3140; -. DR MGI; MGI:1195463; Mr1. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; Q8HWB0; -. DR OMA; GYVDSHP; -. DR OrthoDB; EOG091G0K1X; -. DR PhylomeDB; Q8HWB0; -. DR TreeFam; TF336617; -. DR PRO; PR:Q8HWB0; -. DR Proteomes; UP000000589; Chromosome 1. DR Bgee; ENSMUSG00000026471; Expressed in 197 organ(s), highest expression level in thymus. DR CleanEx; MM_MR1; -. DR ExpressionAtlas; Q8HWB0; baseline and differential. DR Genevisible; Q8HWB0; MM. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; ISO:MGI. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0002367; P:cytokine production involved in immune response; IMP:MGI. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:MGI. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0032611; P:interleukin-1 beta production; IMP:MGI. DR GO; GO:0032620; P:interleukin-17 production; IMP:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Alternative splicing; Cell membrane; Complete proteome; KW Disulfide bond; Endoplasmic reticulum; Glycoprotein; Immunity; KW Immunoglobulin domain; Innate immunity; Membrane; MHC I; KW Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 18 {ECO:0000255}. FT CHAIN 19 341 Major histocompatibility complex class I- FT related gene protein. FT /FTId=PRO_0000344442. FT TOPO_DOM 19 296 Extracellular. {ECO:0000255}. FT TRANSMEM 297 317 Helical. {ECO:0000255}. FT TOPO_DOM 318 341 Cytoplasmic. {ECO:0000255}. FT DOMAIN 204 278 Ig-like C1-type. FT REGION 19 105 Alpha-1. FT REGION 106 197 Alpha-2. FT REGION 198 289 Alpha-3. FT REGION 290 296 Connecting peptide. FT BINDING 61 61 Pathogen-derived ligand. {ECO:0000250}. FT CARBOHYD 103 103 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 116 179 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 218 274 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VAR_SEQ 1 112 Missing (in isoform 2). FT {ECO:0000303|PubMed:16141072}. FT /FTId=VSP_034759. FT MUTAGEN 25 25 Y->L: Loss of MAIT cell activation. FT {ECO:0000269|PubMed:15802267}. FT MUTAGEN 27 27 R->V: Loss of MAIT cell activation. FT {ECO:0000269|PubMed:15802267}. FT MUTAGEN 40 40 F->Y: Impair expression of folded FT protein. {ECO:0000269|PubMed:15802267}. FT MUTAGEN 83 83 L->K: Loss of MAIT cell activation. FT {ECO:0000269|PubMed:15802267}. FT MUTAGEN 86 86 G->R: Loss of MAIT cell activation. FT {ECO:0000269|PubMed:15802267}. FT MUTAGEN 92 92 K->R: Reduced MAIT cell activation. FT {ECO:0000269|PubMed:15802267}. FT MUTAGEN 93 93 A->V: Activated. FT {ECO:0000269|PubMed:15802267}. FT MUTAGEN 99 99 Q->R: Activated. FT {ECO:0000269|PubMed:15802267}. FT MUTAGEN 110 110 Y->I: Impair expression of folded FT protein. {ECO:0000269|PubMed:15802267}. FT MUTAGEN 112 112 R->E: Loss of MAIT cell activation. FT {ECO:0000269|PubMed:15802267}. FT MUTAGEN 128 128 L->Q: Impair expression of folded FT protein. {ECO:0000269|PubMed:15802267}. FT MUTAGEN 170 170 Y->R: Loss of MAIT cell activation. FT {ECO:0000269|PubMed:15802267}. FT MUTAGEN 181 181 A->E: Reduced MAIT cell activation. FT {ECO:0000269|PubMed:15802267}. FT MUTAGEN 279 279 C->G: No effect on cell surface FT expression. FT {ECO:0000269|PubMed:12794138}. SQ SEQUENCE 341 AA; 39391 MW; B21D27227EEFC623 CRC64; MMLLLPLLAV FLVKRSHTRT HSLRYFRLAV SDPGPVVPEF ISVGYVDSHP ITTYDSVTRQ KEPKAPWMAE NLAPDHWERY TQLLRGWQQT FKAELRHLQR HYNHSGLHTY QRMIGCELLE DGSTTGFLQY AYDGQDFIIF NKDTLSWLAM DYVAHITKQA WEANLHELQY QKNWLEEECI AWLKRFLEYG RDTLERTEHP VVRTTRKETF PGITTFFCRA HGFYPPEISM TWMKNGEEIA QEVDYGGVLP SGDGTYQTWL SVNLDPQSND VYSCHVEHCG RQMVLEAPRE SGDILRVSTI SGTTILIIAL AGVGVLIWRR SQELKEVMYQ PTQVNEGSSP S // ID HMR1_PANTR Reviewed; 341 AA. AC Q9BCU3; Q7JGS2; Q9BCU2; Q9BCU4; DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 23-MAY-2018, entry version 103. DE RecName: Full=Major histocompatibility complex class I-related gene protein; DE AltName: Full=MHC class I-related gene protein; DE Flags: Precursor; GN Name=MR1; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, RP AND VARIANT THR-197. RX PubMed=11797097; DOI=10.1007/s00251-001-0380-1; RA Parra-Cuadrado J.F., del Moral M.G., Garcia-Pavia P., Setien F., RA Martinez-Naves E.; RT "Characterization of the MHC class I-related MR1 locus in nonhuman RT primates."; RL Immunogenetics 53:643-648(2001). CC -!- FUNCTION: Antigen-presenting molecule specialized in presenting CC microbial vitamin B metabolites. Involved in the development and CC expansion of a small population of T-cells expressing an invariant CC T-cell receptor alpha chain called mucosal-associated invariant T- CC cells (MAIT). MAIT lymphocytes are preferentially located in the CC gut lamina propria and therefore may be involved in monitoring CC commensal flora or serve as a distress signal. Expression and MAIT CC cell recognition seem to be ligand-dependent (By similarity). CC {ECO:0000250}. CC -!- SUBUNIT: Heterodimerizes with B2M, this interaction is required CC for surface expression. Associated with the peptide-loading CC complex, TAPBP, CALR and PDIA3 (By similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass CC membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. CC Endoplasmic reticulum {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; Synonyms=MR1B1; CC IsoId=Q9BCU3-1; Sequence=Displayed; CC Name=2; Synonyms=MR1B2; CC IsoId=Q9BCU3-2; Sequence=VSP_034760; CC -!- DOMAIN: The alpha-3 region and to a lesser extent the CC transmembrane and cytosolic domains regulate surface expression. CC The alpha-3 region mediates interaction with B2M (By similarity). CC {ECO:0000250}. CC -!- DOMAIN: The ligand-binding groove is ideally suited to present CC small organic compounds that can originate from vitamins rather CC than antigenic peptides. {ECO:0000250}. CC -!- PTM: N-glycosylated. {ECO:0000250}. CC -!- MISCELLANEOUS: MR1 is detected in an open versus folded CC conformation. Only the folded MR1 conformer activates MAIT cells CC (By similarity). {ECO:0000250}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AJ275982; CAC34274.1; -; mRNA. DR EMBL; AJ275983; CAC34275.1; -; mRNA. DR EMBL; AJ275984; CAC34272.1; -; mRNA. DR EMBL; AJ275985; CAC34273.1; -; mRNA. DR RefSeq; NP_001065258.1; NM_001071790.1. [Q9BCU3-2] DR UniGene; Ptr.6698; -. DR ProteinModelPortal; Q9BCU3; -. DR SMR; Q9BCU3; -. DR STRING; 9598.ENSPTRP00000002915; -. DR PaxDb; Q9BCU3; -. DR PRIDE; Q9BCU3; -. DR GeneID; 457562; -. DR KEGG; ptr:457562; -. DR CTD; 3140; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; Q9BCU3; -. DR Proteomes; UP000002277; Unplaced. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Cell membrane; Complete proteome; KW Disulfide bond; Endoplasmic reticulum; Glycoprotein; Immunity; KW Immunoglobulin domain; Innate immunity; Membrane; MHC I; Polymorphism; KW Reference proteome; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 22 {ECO:0000255}. FT CHAIN 23 341 Major histocompatibility complex class I- FT related gene protein. FT /FTId=PRO_0000344443. FT TOPO_DOM 23 302 Extracellular. {ECO:0000255}. FT TRANSMEM 303 323 Helical. {ECO:0000255}. FT TOPO_DOM 324 341 Cytoplasmic. {ECO:0000255}. FT DOMAIN 203 299 Ig-like C1-type. FT REGION 23 109 Alpha-1. {ECO:0000250}. FT REGION 110 201 Alpha-2. {ECO:0000250}. FT REGION 202 293 Alpha-3. {ECO:0000250}. FT REGION 294 302 Connecting peptide. {ECO:0000250}. FT BINDING 65 65 Pathogen-derived ligand. {ECO:0000250}. FT CARBOHYD 107 107 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 120 183 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 222 278 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VAR_SEQ 203 294 Missing (in isoform 2). FT {ECO:0000303|PubMed:11797097}. FT /FTId=VSP_034760. FT VARIANT 197 197 I -> T. {ECO:0000269|PubMed:11797097}. FT /FTId=VAR_045611. SQ SEQUENCE 341 AA; 39394 MW; FBFA822BCAB2C7A8 CRC64; MGELMAFLLP LIIVLMVKHS DSRTHSLRYF RLGVSDPIHG VPEFISVGYV DSHPITTYDS VTRQKEPRAP WMAENLAPDH WERYTQLLRG WQQMFKVELK RLQRHYNHSG SHTYQRMIGC ELLEDGSTTG FLQYAYDGQD FLIFNKDTLS WLAVDNVAHT IKQAWEANQH ELLYQKNWLE EECIAWLKRF LEYGKDILQR TEPPLVRVNR KETFPGVTAL FCKAHGFYPP EIYMTWMKNG EEIVQEIDYG DILPSGDGTY QTWASVELDP QSSNLYSCHV EHCGVHMVLQ VPQESETIPL VMKAVSGSIV LVIVLAGVGV LVWRRRPREQ NGAIYLPTPD R // ID HMR1_PONAB Reviewed; 340 AA. AC Q5RD09; DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot. DT 21-DEC-2004, sequence version 1. DT 23-MAY-2018, entry version 90. DE RecName: Full=Major histocompatibility complex class I-related gene protein; DE AltName: Full=MHC class I-related gene protein; DE Flags: Precursor; GN Name=MR1; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Heart; RG The German cDNA consortium; RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Antigen-presenting molecule specialized in presenting CC microbial vitamin B metabolites. Involved in the development and CC expansion of a small population of T-cells expressing an invariant CC T-cell receptor alpha chain called mucosal-associated invariant T- CC cells (MAIT). MAIT lymphocytes are preferentially located in the CC gut lamina propria and therefore may be involved in monitoring CC commensal flora or serve as a distress signal. Expression and MAIT CC cell recognition seem to be ligand-dependent (By similarity). CC {ECO:0000250}. CC -!- SUBUNIT: Heterodimerizes with B2M, this interaction is required CC for surface expression. Associated with the peptide-loading CC complex, TAPBP, CALR and PDIA3 (By similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass CC membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. CC Endoplasmic reticulum {ECO:0000250}. CC -!- DOMAIN: The alpha-3 region and to a lesser extent the CC transmembrane and cytosolic domains regulate surface expression. CC The alpha-3 region mediates interaction with B2M (By similarity). CC {ECO:0000250}. CC -!- DOMAIN: The ligand-binding groove is ideally suited to present CC small organic compounds that can originate from vitamins rather CC than antigenic peptides. {ECO:0000250}. CC -!- PTM: N-glycosylated. {ECO:0000250}. CC -!- MISCELLANEOUS: MR1 is detected in an open versus folded CC conformation. Only the folded MR1 conformer activates MAIT cells CC (By similarity). {ECO:0000250}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR858109; CAH90348.1; -; mRNA. DR RefSeq; NP_001125167.1; NM_001131695.1. DR UniGene; Pab.14502; -. DR ProteinModelPortal; Q5RD09; -. DR SMR; Q5RD09; -. DR STRING; 9601.ENSPPYP00000000505; -. DR PRIDE; Q5RD09; -. DR Ensembl; ENSPPYT00000000526; ENSPPYP00000000505; ENSPPYG00000000445. DR GeneID; 100172054; -. DR KEGG; pon:100172054; -. DR CTD; 3140; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; Q5RD09; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000001595; Chromosome 1. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Cell membrane; Complete proteome; Disulfide bond; KW Endoplasmic reticulum; Glycoprotein; Immunity; Immunoglobulin domain; KW Innate immunity; Membrane; MHC I; Reference proteome; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1 22 {ECO:0000255}. FT CHAIN 23 340 Major histocompatibility complex class I- FT related gene protein. FT /FTId=PRO_0000344444. FT TOPO_DOM 23 302 Extracellular. {ECO:0000255}. FT TRANSMEM 303 323 Helical. {ECO:0000255}. FT TOPO_DOM 324 340 Cytoplasmic. {ECO:0000255}. FT DOMAIN 203 294 Ig-like C1-type. FT REGION 23 109 Alpha-1. {ECO:0000250}. FT REGION 110 201 Alpha-2. {ECO:0000250}. FT REGION 202 293 Alpha-3. {ECO:0000250}. FT REGION 294 302 Connecting peptide. {ECO:0000250}. FT BINDING 65 65 Pathogen-derived ligand. {ECO:0000250}. FT CARBOHYD 107 107 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 120 183 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 222 278 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 340 AA; 39216 MW; 81FB787F03F06E9F CRC64; MGELTAFLLP LIIVLMVKHS NSRTHSLRYF RLGVSDPIHG VPEFISVGYV DSHPITTYDS VTQQKEPRAP WMAENLAPDH WERYTQLLRG WQQMFKVELK RLQRHYNHSG SHTYQRMIGC ELLEDGSTTG FLQYAYDGQD FLIFNKDTLS WLAVDNVAHT IKRAWEANQH ELQYQKNWLE EECIAWLKRF LEYGKDTLQR TEPPLVRVNR KETFPGVTTL FCKAHGFYPP EIYMTWMKNG EEIVQEMDYG DILPSGDGTY QTWASVELDP QSSNLYSCHV EHCGVHVVLQ VPQESEAIPL VMKAVSGSIV FVIVLAGVGV LVWRRRPREQ NGAVYLPTPD // ID HMR1_RAT Reviewed; 343 AA. AC O19477; DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot. DT 22-JUL-2008, sequence version 2. DT 23-MAY-2018, entry version 114. DE RecName: Full=Major histocompatibility complex class I-related gene protein; DE AltName: Full=MHC class I-related gene protein; DE Flags: Precursor; GN Name=Mr1; Synonyms=Hlals; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway; RX PubMed=15057822; DOI=10.1038/nature02426; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 25-342, AND TISSUE SPECIFICITY. RC STRAIN=Lewis.1W; RX PubMed=9553154; DOI=10.1007/s002510050385; RA Walter L., Guenther E.; RT "Isolation and molecular characterization of the rat MR1 homologue, a RT non-MHC-linked class I-related gene."; RL Immunogenetics 47:477-482(1998). CC -!- FUNCTION: Antigen-presenting molecule specialized in presenting CC microbial vitamin B metabolites. Involved in the development and CC expansion of a small population of T-cells expressing an invariant CC T-cell receptor alpha chain called mucosal-associated invariant T- CC cells (MAIT). MAIT lymphocytes are preferentially located in the CC gut lamina propria and therefore may be involved in monitoring CC commensal flora or serve as a distress signal. Expression and MAIT CC cell recognition seem to be ligand-dependent (By similarity). CC {ECO:0000250}. CC -!- SUBUNIT: Heterodimerizes with B2M, this interaction is required CC for surface expression. Associated with the peptide-loading CC complex, TAPBP, CALR and PDIA3 (By similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass CC membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. CC Endoplasmic reticulum {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Expressed in kidney,liver, testis, spleen, CC thymus, brain, and heart. {ECO:0000269|PubMed:9553154}. CC -!- DOMAIN: The alpha-3 region and to a lesser extent the CC transmembrane and cytosolic domains regulate surface expression. CC The alpha-3 region mediates interaction with B2M (By similarity). CC {ECO:0000250}. CC -!- DOMAIN: The ligand-binding groove is ideally suited to present CC small organic compounds that can originate from vitamins rather CC than antigenic peptides. {ECO:0000250}. CC -!- PTM: N-glycosylated. {ECO:0000250}. CC -!- POLYMORPHISM: Does not appear to be polymorphic. CC -!- MISCELLANEOUS: MR1 is detected in an open versus folded CC conformation. Only the folded MR1 conformer activates MAIT cells CC (By similarity). {ECO:0000250}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR03084784; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; Y13972; CAA74305.1; -; mRNA. DR RefSeq; NP_001094105.1; NM_001100635.1. DR UniGene; Rn.163225; -. DR ProteinModelPortal; O19477; -. DR SMR; O19477; -. DR STRING; 10116.ENSRNOP00000004694; -. DR PaxDb; O19477; -. DR PRIDE; O19477; -. DR GeneID; 25119; -. DR KEGG; rno:25119; -. DR UCSC; RGD:1593291; rat. DR CTD; 3140; -. DR RGD; 1593291; Mr1. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; O19477; -. DR OrthoDB; EOG091G0K1X; -. DR PhylomeDB; O19477; -. DR TreeFam; TF336617; -. DR PRO; PR:O19477; -. DR Proteomes; UP000002494; Unplaced. DR Genevisible; O19477; RN. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Cell membrane; Complete proteome; Disulfide bond; KW Endoplasmic reticulum; Glycoprotein; Immunity; Immunoglobulin domain; KW Innate immunity; Membrane; MHC I; Reference proteome; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1 18 {ECO:0000255}. FT CHAIN 19 343 Major histocompatibility complex class I- FT related gene protein. FT /FTId=PRO_0000344446. FT TOPO_DOM 19 298 Extracellular. {ECO:0000255}. FT TRANSMEM 299 319 Helical. {ECO:0000255}. FT TOPO_DOM 320 343 Cytoplasmic. {ECO:0000255}. FT DOMAIN 204 286 Ig-like C1-type. FT REGION 19 105 Alpha-1. {ECO:0000250}. FT REGION 106 197 Alpha-2. {ECO:0000250}. FT REGION 198 289 Alpha-3. {ECO:0000250}. FT REGION 290 298 Connecting peptide. {ECO:0000250}. FT BINDING 61 61 Pathogen-derived ligand. {ECO:0000250}. FT CARBOHYD 103 103 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 116 179 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 218 274 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT CONFLICT 284 284 V -> I (in Ref. 2; CAA74305). FT {ECO:0000305}. SQ SEQUENCE 343 AA; 39571 MW; 2D1AC536F7E5A626 CRC64; MMFLLPFLTV FLAKQSHTRT HSLRYFRLAI SDPGPGVPEF ISVGYVDSHP ITTYDSVTRQ KEPRAPWMAE NLAPDHWERY TQLLRGWQRT FQTELRHLQR HYNHSGLHTY QRMIGCELLE DGSTTGFLQY AYDGQDFIVF DKDTLSWLAM DNVAHITKRA WEANLHELQY QKNWLEEECI AWLKRFLEYG SDALERTEHP VVRTTRKETF PGITTLFCRA HGFYPPEISM IWKKNGEEIV QEVDYGGVLP SGDGTYQMWV SVDLDPQTKD IYSCHVEHCG LQMVLEAPQE SGNTLLVANT ISGTIILIIV LAGVGALIWR RRSREPKEVM YQPTQVNEGS SPS // ID I3IZ00_ORENI Unreviewed; 336 AA. AC I3IZ00; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 37. DE SubName: Full=Major histocompatibility complex class I LGA {ECO:0000313|Ensembl:ENSONIP00000001840}; GN Name=LOC100690338 {ECO:0000313|Ensembl:ENSONIP00000001840}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000001840, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000001840} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01046440; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01046441; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01046442; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSONIT00000001839; ENSONIP00000001840; ENSONIG00000001466. DR eggNOG; ENOG410KG2Z; Eukaryota. DR eggNOG; ENOG4110SQP; LUCA. DR GeneTree; ENSGT00740000114936; -. DR TreeFam; TF334460; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 284 302 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 179 270 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 336 AA; 38981 MW; 20CBAAC49E509AF4 CRC64; WALASYIPGS AHFPEFTVVL MLDDIQVGYY DSKVNQVMRT STASDHKAEL NLGQEPVNVL RDIYSSMRKR LNLVKHRFNL TIDGVHVQQR VTGCEVLEDG QPALIMFRDG SNGQDADSLL YNMTHFTYAV REGWEIQWDA LKKTSFQMLY SNIYLPFCVR TLQHFLEREK HLVMRRVKPR LRFITRQVVG GAQVTCLATD FYPRHINLSL LRDGQPVDEG EVRVGSVLPN GNGLYQVRKT LMVGEKELQR KHNYTCEAFH LSLDNRLRIN WRAESSYSHR VHSISPLVVL MLAAVLLLVL VLRRRRRRRK ERSEGMATET QEQQYVWMQT DSLTSI // ID I3IZ01_ORENI Unreviewed; 362 AA. AC I3IZ01; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 41. DE SubName: Full=Major histocompatibility complex class I LGA {ECO:0000313|Ensembl:ENSONIP00000001841}; GN Name=LOC100690338 {ECO:0000313|Ensembl:ENSONIP00000001841}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000001841, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000001841} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01046440; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01046441; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01046442; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_019220316.1; XM_019364771.1. DR ProteinModelPortal; I3IZ01; -. DR Ensembl; ENSONIT00000001840; ENSONIP00000001841; ENSONIG00000001466. DR GeneID; 100690338; -. DR eggNOG; ENOG410KG2Z; Eukaryota. DR eggNOG; ENOG4110SQP; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3IZ01; -. DR OMA; CHIDHAS; -. DR OrthoDB; EOG091G0B7M; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003671813. FT TRANSMEM 310 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 41698 MW; 1606CBF926738343 CRC64; MFVLQLMLMS LLLHHTMSSG TGRHSLWALA SYIPGSAHFP EFTVVLMLDD IQVGYYDSKV NQVMRTSTAS DHKAELNLGQ EPVNVLRDIY SSMRKRLNLV KHRFNLTIDG VHVQQRVTGC EVLEDGQPAL IMFRDGSNGQ DADSLLYNMT HFTYAVREGW EIQWDALKKT SFQMLYSNIY LPFCVRTLQH FLEREKHLVM RRVKPRLRFI TRQVVGGAQV TCLATDFYPR HINLSLLRDG QPVDEGEVRV GSVLPNGNGL YQVRKTLMVG EKELQRKHNY TCEAFHLSLD NRLRINWRAE SSYSHRVHSI SPLVVLMLAA VLLLVLVLRR RRRRRKERSE GMATETQEQV GESEQSDDLV TS // ID I3J696_ORENI Unreviewed; 314 AA. AC I3J696; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000004386}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004386, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000004386} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01067423; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01067424; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3J696; -. DR Ensembl; ENSONIT00000004388; ENSONIP00000004386; ENSONIG00000003482. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3J696; -. DR OrthoDB; EOG091G0GOV; -. DR TreeFam; TF334519; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}. FT DOMAIN 196 274 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 314 AA; 35888 MW; 2C02886F1FBD4728 CRC64; LYFVTRMLTV NSATHSLIYI YTALSADLGL PGVKPFDRFD TDNPRKTPTT NWARQHLTTE YLDKGTQSRL SKQQWFGVNL DVVMTRMGHS ASDGDVHVLQ WLHGCYGETN PSEERLRFVR GVDKYAYDGD DLMSFDYVTL RWSAATEAAK PIADKWNGVT VLTEYTNGYL RDECIGWLTR FVGYSQRELR ERAIVPDVYV FARKTRGPIL TLICMASGFS TNTPAMTLMR NGRVLSTDDG LKVFDILPNN DDTFQRRIAV DILQSDKGNF TCNVLEEDTG YHAIKHWRLE DRKTLRAVAW SNIVLLWALL LFST // ID I3J6F8_ORENI Unreviewed; 249 AA. AC I3J6F8; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000004448}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004448, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000004448} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01057189; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3J6F8; -. DR Ensembl; ENSONIT00000004450; ENSONIP00000004448; ENSONIG00000003532. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3J6F8; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}. FT DOMAIN 14 185 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 208 249 IGc1. {ECO:0000259|Pfam:PF07654}. SQ SEQUENCE 249 AA; 29198 MW; 2EA9926282F9312E CRC64; LTNSVSLTAK HSWKFYVMIS SEFPNTPDYL AVITIDDVMM GSYNINMKTL EAQQDWVREF IKDDPRQWET YTKNCMNYQQ ILIDETRIFK QHSNEIEGAH LIQQILGCEW DDETEKINGF NLFGYNGEDF IAFDLETGTW ITSNVEAEIT KQKWNGNIAK NSLLKYFLKN MCPDGMKIPL NYAKHFLNRK GKLTFFFHFP QKTPSSPVSC HATGFYPDRA VMFWRKDGEE LHEYVDHKEI QSNHDGTFQ // ID I3J6F9_ORENI Unreviewed; 365 AA. AC I3J6F9; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000004449}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004449, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000004449} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01057191; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01057192; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01057193; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3J6F9; -. DR Ensembl; ENSONIT00000004451; ENSONIP00000004449; ENSONIG00000003533. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3J6F9; -. DR OMA; VPNFPEY; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003672545. FT TRANSMEM 312 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 300 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 41806 MW; 1B9394FA3A15ED79 CRC64; ASSLNMMKKP MVLLLLCHAA SAAIHSFKMY FMISSGVPNF PEYLAAVNVE DVMIAYYDSN MNEPEPRQDW AKEVKKEDLQ LCTEHGQMII LYQQMLEVAT ASFKQHTNQT KGVHIIQELT GYEWDDETEK VTGIKQFGYN GEDFIALDIE TETWISSNPQ AEITKQIWNA HTNKGFWKNV FATTFPAWSS MYMNYAESFV HRKVPPSVSL LQKTSSSPVS CHATGFYPDR AVMFWRKDGE EIHEDVDHKE ILPNHDGTFQ MSVDLDISSI GPEDWRRYDC VFQLSGFEDD VVTRLNESIT RTNWDKHLIR SIPIITAMVV LVVIVTVGVG FAVYKRKKGK QLKRLPCVNS PELEKILKHE VNCVH // ID I3J6G4_ORENI Unreviewed; 359 AA. AC I3J6G4; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000004454}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004454, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000004454} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01057200; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01057201; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3J6G4; -. DR Ensembl; ENSONIT00000004456; ENSONIP00000004454; ENSONIG00000003537. DR eggNOG; ENOG410KH3D; Eukaryota. DR eggNOG; ENOG4110RPC; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3J6G4; -. DR OMA; CERDENT; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 311 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 204 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 40711 MW; F3FED5C0F39A3501 CRC64; PNLVILLLGT NELVQSTQMK HSLKYFVTGS SGVPNIPEFM GVVVFNGIQA GYCDSNNMTL KPKQDWAKKI LQTNRQQKEW YNHMCFKEEP NFFKNMISNV KQFTKISSGV HVLQRIGGCE RDENTGEVTG LVHFGYNAED FLEFNLETLT WIALKPEADI IKQEWDADRV RTKHNENFLT QICPEWLKTY VDSAKSPLQK SVLPSVSLLQ KTPSSPVSCH ATGFYPDRAV MFWRKDGEEL HEGVDPGEIL PNSDETFQMS VDLNVSSITP EDWRRYDCVF QLSDGEDDII TSLNKTLIRT NWVENITKGN IIGVKTVVVS VVFVVIGFGV FKKKRGEIFS VAYKSNSNSS VSNTVFWTL // ID I3J6G9_ORENI Unreviewed; 348 AA. AC I3J6G9; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000004459}; GN Name=LOC102079388 {ECO:0000313|Ensembl:ENSONIP00000004459}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004459, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000004459} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01057212; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01057213; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01057214; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01057215; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005464783.1; XM_005464726.3. DR RefSeq; XP_019206258.1; XM_019350713.1. DR ProteinModelPortal; I3J6G9; -. DR Ensembl; ENSONIT00000004461; ENSONIP00000004459; ENSONIG00000003541. DR GeneID; 102079388; -. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3J6G9; -. DR OMA; ADIVNIM; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 348 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003672212. FT TRANSMEM 323 345 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 204 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 348 AA; 40079 MW; 20C0AC7788B5771D CRC64; MRIICFYLCF FFFYSTSSAV KHSLQYLVTA SSGVPNIPEF MGAVVLDNIH MVYCDSINKI LEPRQNWVKE MFENDTELLE IYTRKCTVIL PQNLGNRISS LKEQFQSEGV HILQMREGCE WDEKTGEVTG FLQYGYNGED FVEFDLKTLT WIALKPEAAI TKQRWDADSV RTKLNEDFLT NIYPQWMKMF LSYGKRSLQR TVLPSVSLLQ KTPSSPIICH ATGFYPDRAV MFWKKDGEEI HEGVDPGEIL PNNDGSFQVN VDLNVSSVKP KDWRRYDCVF QFSDGEHVIT KLDKTVIRTN CGKKILCNDG GERNILFADI VNIMLYLFIL YWIPGGITAM LGITLDRE // ID I3J6H0_ORENI Unreviewed; 344 AA. AC I3J6H0; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000004460}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004460, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000004460} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01057216; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01057217; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01057218; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01057219; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01057220; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01057221; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3J6H0; -. DR STRING; 8128.ENSONIP00000004460; -. DR Ensembl; ENSONIT00000004462; ENSONIP00000004460; ENSONIG00000003542. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3J6H0; -. DR OMA; DETRTVD; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 344 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003672301. FT TRANSMEM 320 342 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 204 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 344 AA; 38665 MW; 894AD0F7C745959A CRC64; MRIICFYSCC FFLYSTSSAV KHSLQLLVTA SSGVPNIPEF MGAMMLDGIQ MGYCDSINKI LEPRQDWVKK MFENDTELLE MYTRYCFVNL PNNFGKRISS LEEQFQSEGV HILQMREGCE WDEKTGNVTG FLQYGYNGEG FVEFDLKTLT WIALKPEAAI TKQKWDADSV RTKHNENLLT NIYQKWMKKF LSYGKSSLQR TVLPSVSLLQ KTPSSPIICH ATGFYPDRAV MFWKKDGEEI HEGVDPGEIL PNNDGTFQSN VDLNVSSVTP EDWSRYDCVF QLSNDEHVIT KLDKTVISTK CGKKIPCNGG VDTPPATMTA VIAVVVAAVV ALSVAAVGFV VYKK // ID I3J6H6_ORENI Unreviewed; 337 AA. AC I3J6H6; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000004466}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004466, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000004466} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01057225; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3J6H6; -. DR PRIDE; I3J6H6; -. DR Ensembl; ENSONIT00000004468; ENSONIP00000004466; ENSONIG00000003547. DR eggNOG; ENOG410INYR; Eukaryota. DR eggNOG; ENOG4110Q3N; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3J6H6; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 337 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003672548. FT TRANSMEM 310 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 204 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 337 AA; 38887 MW; FA76DDED6D196447 CRC64; KEKMMFFLFP LFCHGLFAMK HSLMHSVTGS SGDPNISEFA GVVLVDGTEA VYCDSRNKIL EPRQDWMKKI FSNDTQHLAL YTQQCFEDQP RIFRFLISTL KQLLHQIEGV HILQRTGGCE WNENTGEVTG VLQYWYNGEG FLEFDLKTLT WIPLKPEAAI IKQQWDTDTA VIKEVESLLT KFCPEWLKRY LNYGSSFLQR TVLPSVSLLQ KTSSSPVSCH ATGFYPDRAA MFWRKDGEEI HEGVDHREIL PNNDGTFQTT VNLNVSSVRP EDWKKYDCVF QLSGVENNIV TKLHKTVIRT NWDENNRMEF LSIIIVPVLI LVAAVGFFVY KKKRGER // ID I3J6H7_ORENI Unreviewed; 339 AA. AC I3J6H7; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000004467}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004467, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000004467} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01057238; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3J6H7; -. DR Ensembl; ENSONIT00000004469; ENSONIP00000004467; ENSONIG00000003548. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3J6H7; -. DR OMA; TWITANQ; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 197 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 339 AA; 39151 MW; 7408F09F3D7D067A CRC64; SSGFLAMHVW RPVSSKHSLK YFFTETPGAQ SIPEFVGVGF IDDVQFGSWN SRRGEDIKKD WIKFFEDEPQ LLQEYISQCS TFHHYFKDTI KTLNQHLNQT EGVHILQMTS GCEWDDETGE SNGYSQYGYD GEDFIVFDLQ TGTWITANQQ AETTKLKWNT EHGRLQRYKN FLSNSCPEFL KKHWHYGRSF LEKEILPSVS LLQKTSSSPV SCHATGFYPQ RAMMFWRKDG EEIHESVVHG ELFSNNDGTF QLSVDLNVSS VRSEDWKRYD CVFQISGVKM GRDDSIVTKL DEAVIWTNWE KPTNIMTFIS AALVLLAFII IAAVAFVIYK RKKGEKSYL // ID I3JBE3_ORENI Unreviewed; 355 AA. AC I3JBE3; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000006183}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000006183, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000006183} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01057807; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01057808; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01057809; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3JBE3; -. DR Ensembl; ENSONIT00000006187; ENSONIP00000006183; ENSONIG00000004918. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JBE3; -. DR OMA; PTITIMG; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 355 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003672790. FT TRANSMEM 303 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 273 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 355 AA; 40771 MW; EF8B5F15CB80EACC CRC64; MLKELMILFF CHTASAVIHS LICNFMISSG LPNAPEYLVI LNLDNVLMAY YDTNMKTVEP RQHWLKEMKK EDLDTWENYM QNAPLYQYRL AEDTKSFFQQ QTGGFHVIQQ ITGCEWDDET GGIHSFTIFG YNGEDFIIFD KDTKTWIAST PEAEIAKENF NGKKARTEEF KTYHKNDCPI LLKKSFNYAK SVLHRTVLPS VSLLQKTPSS PVSCHATGFY PNRAMMFWRK DREEIHERVV HREMLPNQDG TFQIQIDLNI SSVTPEDWRR YDCVFQLSGI KEDVVIGLET SLIRTNCGTL TTIIIVVAVI VLLVLIIIGA IGFTVYKKKK VSEQPPTSPP ETDCELSERL NSETI // ID I3JBX7_ORENI Unreviewed; 351 AA. AC I3JBX7; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000006367}; GN Name=LOC100704307 {ECO:0000313|Ensembl:ENSONIP00000006367}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000006367, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000006367} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01054650; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01054651; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01054652; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01054653; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005464372.1; XM_005464315.3. DR ProteinModelPortal; I3JBX7; -. DR STRING; 8128.ENSONIP00000006367; -. DR Ensembl; ENSONIT00000006372; ENSONIP00000006367; ENSONIG00000005063. DR GeneID; 100704307; -. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JBX7; -. DR OMA; QRVYGCD; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF334519; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 351 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003672115. FT TRANSMEM 318 342 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 213 303 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 351 AA; 39948 MW; 31F176EBA1AA06F8 CRC64; MLGSKMFTLA LFALLCPGPT QSRDTHSLHY IYTALSKPVG LPGIHEFTAM GLLDGRMIDY FDSEHQAKVP KQQWMRERLP ADYWDKGTQS RKSKQQWFKV NIGILMERMR QNDSGTPHIL QWMHGCEGET QPDGTLRFVR GMDMYSYDGD DFLSFDGKNE VWVAPTPQAL STKRKWDNQT VLKEYTKGYL ENECIDWLSK FVNYGKEKLK SVPEVYVFAK CSTVDTNVVL TCLATGFYPA ELTVTIRRNG RVLTADDGLM SSGLLPNHDE TFQRRDNVEV LKSDVSVFSC EVRHEATNEH AVKDWDDRLL PDSEGSSVHI LVAAVVVPFV LVGVAAVLLF LYKNLNKRCW S // ID I3JBX8_ORENI Unreviewed; 335 AA. AC I3JBX8; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000006368}; GN Name=LOC100704307 {ECO:0000313|Ensembl:ENSONIP00000006368}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000006368, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000006368} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01054650; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01054651; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01054652; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01054653; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSONIT00000006373; ENSONIP00000006368; ENSONIG00000005063. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 310 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 301 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 335 AA; 38112 MW; F0336EE24E5317B6 CRC64; IFHFLVVAQH YTGITVNYTH SLHYIYTALS KPVGLPGIHE FTAMGLLDGR MIDYFDSEHQ AKVPKQQWMR ERLPADYWDK GTQSRKSKQQ WFKVNIGILM ERMRQNDSGT PHILQWMHGC EGETQPDGTL RFVRGMDMYS YDGDDFLSFD GKNEVWVAPT PQALSTKRKW DNQTVLKEYT KGYLENECID WLSKFVNYGK EKLKSSPPAV PEVYVFAKCS TVDTNVVLTC LATGFYPAEL TVTIRRNGRV LTADDGLMSS GLLPNHDETF QRRDNVEVLK SDVSVFSCEV RHEATNEHAV KDWDSEGSSV HILVAAVVVP FVLVGVAAVL LFLYK // ID I3JBY4_ORENI Unreviewed; 353 AA. AC I3JBY4; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000006374}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000006374, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000006374} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01054655; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01054656; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3JBY4; -. DR STRING; 8128.ENSONIP00000006374; -. DR Ensembl; ENSONIT00000006379; ENSONIP00000006374; ENSONIG00000005069. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JBY4; -. DR OMA; RMFGCEI; -. DR OrthoDB; EOG091G0BBK; -. DR TreeFam; TF334519; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 353 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003672116. FT TRANSMEM 319 341 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 213 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 353 AA; 40358 MW; AD2BF46DFC873136 CRC64; FSLLPLLFSA DVLLCVCSVF SNTHSLHYIY TALSKPVSLP GIHEFTAMGL LDDRMIDYFD SENQAKVPKQ QWMRERLPAD YWDKGTQSRK SKQQWFKVNI GILMERMRQN DSDNLHVLQW MHGCEGETNS DGTLRFVRGM DMYSYDGGDF LSFDDKNGVW VAPTPEAEPT KRKWDDVQVL KEYTKGYLEN ECIDWLSKFV NYGQQQLKKK SPPELHVFAK NSRVQTNIVL TCLATGFYPK DVIMRIRRNG RVLTADDGLK SSGPLPNNDD TFQRREYVEV LKSDTSPYSC EVFHKATNVS LSESWDLSML PVPDDDGSAV IGLVAALLLV LIGVGVILLV LRKRRINGRW NEQ // ID I3JJ83_ORENI Unreviewed; 344 AA. AC I3JJ83; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000008927}; GN Name=LOC102076776 {ECO:0000313|Ensembl:ENSONIP00000008927}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008927, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000008927} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01029170; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005457641.1; XM_005457584.3. DR Ensembl; ENSONIT00000008932; ENSONIP00000008927; ENSONIG00000007074. DR GeneID; 102076776; -. DR eggNOG; ENOG410KFJH; Eukaryota. DR eggNOG; ENOG4110T8Z; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JJ83; -. DR OMA; EYFRAYV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 344 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003672608. FT TRANSMEM 310 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 201 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 344 AA; 39389 MW; 58D0C36D20A2BAAA CRC64; MNSLCLFLLS CHVSSAVKHS LKYFITASSG ISDFPEFVGA AVVDGVLVGY CDSSIRRAEP KLEWMKELIK KDPQHLEWYT QKCSGNQQVF RANINSLKKR LNQTGGVHIF QRMNGCEWDD ETDTITGFNQ YGYDGEDFIA LDLQTLTWIA PKPQAVVTKL QWDTEKPRLE HNKNYYINRC PDWLKKYVKY GRSFLQRTVL PSVSLLQRTP SSLVSCHATG FYPERAMMFW RRDEEEIHEG VEHGEILPNH DGSFQMSVEL NVSSIKPDDW RRYDCVFQLS DVKEDIITKL DKTAIRTNWV SPSVFPVGPV VGGVGGVLLL LAVFGFFIWR RNSNEFQLAN TGEQ // ID I3JJ97_ORENI Unreviewed; 318 AA. AC I3JJ97; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000008941}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008941, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000008941} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01029171; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3JJ97; -. DR Ensembl; ENSONIT00000008946; ENSONIP00000008941; ENSONIG00000007085. DR eggNOG; ENOG410KFJH; Eukaryota. DR eggNOG; ENOG4110T8Z; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JJ97; -. DR OMA; QPRFIAV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 292 314 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 280 IGc1. {ECO:0000259|SMART:SM00407}. FT COILED 90 110 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 318 AA; 36586 MW; B1BF4F4F52D0B772 CRC64; VNVQSYFTQV RMMKYSLKYF LTATSGLPDF PEFVASALVN GVQVGYCDSN IRTAEPTQDW MKKLVKDDPQ HLDWYSEKCF GNQQVFRANI DSLKQRLNQT RGKKKKKKRM NGCEWDDETE EIKGFNQYGY NGEDFIALDL QTLTWIAPKP QAVITKLKWD AEKARLEHNK NYYINRCPDW LKKYVKYGRS FLQRSVLPSV SLLQRSPSSV VSCHATGFYP HRAKMLWRKD EEEFHDGVDK GQILPNHDGS FQTSVQLNVS SIKPEDWRRH LTNTEGLSKP LSCPISLSEF PVGPVVGAAV GVLLLLAVFG FFIWKRNS // ID I3JJA3_ORENI Unreviewed; 366 AA. AC I3JJA3; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000008947}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008947, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000008947} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01029171; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01029172; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01029173; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01029174; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01029175; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01029176; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01029177; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3JJA3; -. DR Ensembl; ENSONIT00000008952; ENSONIP00000008947; ENSONIG00000007090. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JJA3; -. DR OMA; WITRVEE; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 15 {ECO:0000256|SAM:SignalP}. FT CHAIN 16 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012632957. FT TRANSMEM 318 339 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 201 275 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 41612 MW; CF9C517A5095E66F CRC64; MAVFLLLLFC SVSSAVKHSL KYFISGSSGV PNVPEFIGVM VVDGIQTGYC DSSNKTLKPQ LDWAKKILQT NPEQLEWYTQ KCFEDQPNVF RGHIFRWKQR FNQSGGVHVI QRISGCEWDE NTDSVTGVLK YGYNGEGFLE FDLKTLTWIA LKPEADMIKQ KWDADRTRTM ENEDFLTQTC AEWLKMYVDN GKRSLHRTVP PSLSLLQKTP SSPVSCHATG FHPDRVMMFW RKDGDEIHDG VEKGDILPNN DGTFQINVYL NVSSVKPEDW RKYECVFQLL SGENVIVTKL NETMIRTNWR ENIFGTGREK PSDMTVPIIP AVVVLVLIIV AAAAGFAVYK KKKVSERRST SSPDNNAEQI QLNQVK // ID I3JJA6_ORENI Unreviewed; 340 AA. AC I3JJA6; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000008950}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008950, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000008950} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01029201; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSONIT00000008955; ENSONIP00000008950; ENSONIG00000007093. DR eggNOG; ENOG410KF51; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JJA6; -. DR OMA; NTRICKA; -. DR OrthoDB; EOG091G0TWV; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 340 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003673171. FT TRANSMEM 308 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 184 278 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 38852 MW; 6622E3755F96DE7C CRC64; IRTMGRLLLL LFLCQFGSSV KHSLKFFFCQ TSGVQNIPEF VVVGLVDGVQ KSYYDSNTGR PEPKTEWMKK LMKDDPQHLE WYTARSFHTQ DLFKHYIENL RKRFNQTEGV HILQSMNGCE WDDETGQINA FNQYGYDGED FLTFDPQRLT WIALKPKAVI TKLRWDGEED QLKCNKNFYI HECPEILKKY IQCGKNFSQT AVLPSVSLLQ KSSSSPVSCH ATGFYPDRGL MFWRKDGEEL HEGVDPGEIL PNNDGTFQLS VDLKLSSVTP EDWERYDCVF QLFGANEYII TKLDKTLIRT NWGKPAHITA TVVVLAIILT AAVAAVAAVA VIAYKRKKGE // ID I3JJA7_ORENI Unreviewed; 354 AA. AC I3JJA7; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000008951}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008951, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000008951} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01029201; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3JJA7; -. DR Ensembl; ENSONIT00000008956; ENSONIP00000008951; ENSONIG00000007094. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JJA7; -. DR OMA; TSRMKIF; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 354 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003672451. FT TRANSMEM 304 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 354 AA; 40465 MW; BA79F623D81C4DDC CRC64; MNSVLILLLC CHVASPVKHS LKYFFTESPG AQSIPEFVAV AIVDDVQIGD SNSVREATPK KDWIKFFEDH PQHLQWYSLQ SHDSHHFFKA TIETLRQRLN QTEGVHILQR MKGCEWDDET GEINGYDQYG YDREDFLVYD LKTLTWIAPK PHAVLTKMRF DAHEHQFESN KNFLVYQCPD FLKEYLRYGK RFLQTAVLPK VSLLQKTPSS PVSCHATGFY PDRAVMFWRK DGVQLHEGVD PGEILPNNDG TFQMSIDLNV SSVTPEDWQR YDCVFQLAGV NEHIITKLDK TAIRTNWAEK PADMVTFISA AVVLLTVTII TAVAFVAYKK KKGEKSECAP DDGSEQSERL NPQS // ID I3JJB1_ORENI Unreviewed; 331 AA. AC I3JJB1; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000008955}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008955, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000008955} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01029202; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3JJB1; -. DR Ensembl; ENSONIT00000008960; ENSONIP00000008955; ENSONIG00000007098. DR eggNOG; ENOG410KF51; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JJB1; -. DR OMA; WDRNTRN; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 298 324 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 174 281 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 331 AA; 37724 MW; D2361734B5DE52FF CRC64; LIQSLIIVTV KHSLKFFFTQ TSGVQSIPEF VVVALVDEVQ GGYYDSNTGR PEPKTEWMKK LVKDDPQHLE WYTARSLDVQ HLFKHYIENL RKRFNQTGGV HILQKLDGCE WDDETGEVNG FNQYGYDGED FLALDLQRLT WIALKPQAVI TKLRWDGEKD RLEYNKNFYV HECPEFLKKY VQYGKDFLQT AVLPSVSLLQ KSSSSPVSCH ATGFYPDRAV IFWRKDGEEI PEGVNPGEIL PNNDGTFQLS VDLKLSSVTP EDWERYDCMF QLSGVNEHIV TKLDKAAIRA NWEKPADITV SVVVLAIVLI AAVAVGAAVV FVTYKRKKGE R // ID I3JJB4_ORENI Unreviewed; 218 AA. AC I3JJB4; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000008958}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008958, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000008958} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01029205; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3JJB4; -. DR Ensembl; ENSONIT00000008963; ENSONIP00000008958; ENSONIG00000007100. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JJB4; -. DR OMA; FLMRTGN; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}. FT DOMAIN 30 206 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 218 AA; 25407 MW; 91D5252D971FC5F9 CRC64; MVSWFGRFKD KAKMILFLFP LFYHGLFAVK HSLMHSVTGS SGDPNISEFT GVVLVDGTEA VYCDSRNKIL EPRQEWMKKI FSNDSQHLAS YMQQCFEDQP DIFRFLISTL MQLFNQIEGV HILQRTGGCE WNENTDEVVG MVQYGYHGEG FLELDLKTLT WIPLKPEAAI IKQEWDTDRD VIKEIESLLT KFCPEWLKRY LNYGSSFLQR TGNRNHMT // ID I3JJB5_ORENI Unreviewed; 342 AA. AC I3JJB5; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000008959}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008959, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000008959} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01029212; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSONIT00000008964; ENSONIP00000008959; ENSONIG00000007101. DR eggNOG; ENOG410KF51; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JJB5; -. DR OMA; LENICVQ; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 312 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 185 278 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 342 AA; 39038 MW; 1361A4560750554D CRC64; IKIEQKQVLN INFLLIESQT VKHSLQYFFT QTTGVQSIPE FVAVALVDGV QGGYYDSSTK RAEPKREWIK KLMQDDPQHL QWYADQSLHT NEVFKHYIGS LRQRFNQTGG VHILQSMNGC EWDDETGEVN GFIQYGYDGE DFIALDLQKL TWITAKPQAV IIKLRWDAEK TRLEHNKELF IHKCPELLKN YLQYGRSFLQ TAVLPSVSLL QKSSSSPVSC HATGFYPDRA VMFWRKDGEE THEGVHHTES LPNNDGTFQM SVDLKLSVTP EDWERYDCVF QLFGVNEYIV TKPDKAAIRT NWEKPADIRA TVVVLAIVLI AAVAAGAAGM FVAYKRKKGE RS // ID I3JJB8_ORENI Unreviewed; 366 AA. AC I3JJB8; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000008962}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008962, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000008962} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01029214; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01029215; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01029216; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3JJB8; -. DR Ensembl; ENSONIT00000008967; ENSONIP00000008962; ENSONIG00000007104. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JJB8; -. DR OMA; MKNATQT; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003672613. FT TRANSMEM 318 338 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 195 275 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 41549 MW; 362FFC37CF401552 CRC64; MEKKMKCVLI LLLCCHVGSP VKHSLKYFIT ETPGAQSIPE FVAVAFVDEV PIGDFNSVRG AKPKKDWIKF FEDHPEHLEW YSLQSHESHH FLKATIETLR QCLNQTDGVH ILQKLDGCEW DDETGEVNGF NQYGYDGEDF LAFDLQTMTW ITAKPHAVTT KMIWDADKAR LESNKNFIVH QCLEFLKKYL QKSFLQATVL PSVSLLQKSS SFLISCHATG FFPNRGMMFW RKDGEELHEG VDPGEILPNN DGTFQMSVDL NVSSVTPEDW QRYDCVFQLS GVNEDIINKL DKAVIRTNWE IWGNLQSENN PESVTISIIP SVVVALILIL VAVGVGVYKK KKERNTEPSL GDASEIQNLR CSYLSL // ID I3JML2_ORENI Unreviewed; 267 AA. AC I3JML2; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000010106}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010106, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000010106} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01067886; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01067887; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3JML2; -. DR Ensembl; ENSONIT00000010115; ENSONIP00000010106; ENSONIG00000008025. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JML2; -. DR OMA; HIDLNIS; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 206 227 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 93 181 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 267 AA; 30261 MW; 366233790D134423 CRC64; GVHVIQQITG CEWDDETEKM NGFTTFGYNG EDFIAFDKDS ETWIALTPEA ELAKQDLKTR TEEYKLFHTV TCPSILKNCL KHAESFLNRK VLPSVSLLQT TPSSPVSCHA TGFYPNKAMM FWRKDGEEIH EGVVHRDMLL NQDGSFQFHI DLNISSVTPE DWRRYDCVFQ LSGNKEEVVI GLKKSLISTN WGKSKMKNNE VNTTPIVVAV VVLLVLIVIG AIGFTVYKKK KAKDDKNPVS HCLPLLISRY RLVQVPTILA ELSKQRL // ID I3JNX5_ORENI Unreviewed; 201 AA. AC I3JNX5; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000010569}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010569, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000010569} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01060909; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3JNX5; -. DR Ensembl; ENSONIT00000010578; ENSONIP00000010569; ENSONIG00000008406. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JNX5; -. DR OMA; NTETWIA; -. DR OrthoDB; EOG091G1YBS; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}. FT DOMAIN 86 160 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 201 AA; 23237 MW; CDEFB1FD4A1AAF7C CRC64; MGVNGTTSLK TLYHQYGYDG KDFIIFDLNT ETWIAPKEQA VITKHKWDHD ADWNTQTKHY LTQDCIEWLQ KYVYYGRHSL KRTVLPSVFL LQKSSSSPVF CHATGFHPNR AEMVWRKDGV ELHEGVNKGE ILPNNDGTFQ MSVDLDLSST KPEDWRRYDC VFQISGVSKD FIIKLDKAVI KTNQKGKMGI RGNKDQKPMF S // ID I3JNX6_ORENI Unreviewed; 307 AA. AC I3JNX6; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000010570}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010570, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000010570} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01060911; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3JNX6; -. DR STRING; 8128.ENSONIP00000010570; -. DR PRIDE; I3JNX6; -. DR Ensembl; ENSONIT00000010579; ENSONIP00000010570; ENSONIG00000008407. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JNX6; -. DR OMA; EDRTHNT; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 307 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003673043. FT DOMAIN 202 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 307 AA; 35542 MW; CC2E83F28A56AC23 CRC64; LKMRTFMMQL FYWVASVAAV KHSLKYFYTA SSQVPNFPEF VVVGMVDEVQ MVHYDSVTEK AVPKQDWMNK NTDQQYWERE TGNFMGTHQV FKANIEIAKQ RFNQTGGVHI VQWMYGCEWD DETNEVDGYE QFGYDGEDFI TFDLQTETWV APKQQAVVTK HKLNSNKAFL TSVKNYYTQI CPEWVKKYLN YGRSSLMRTV LPSVSLLQKT PSSAISCHAT GFYPNRVKMI WRKDGEETHE GVEIGEILTN NDGTFQMTVN LDLTSVPAED WRRYDCVFQL SGVNEDIVTK LDNTVIRTND GKSIIRN // ID I3JNX8_ORENI Unreviewed; 305 AA. AC I3JNX8; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000010572}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010572, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000010572} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01060912; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3JNX8; -. DR STRING; 8128.ENSONIP00000010572; -. DR Ensembl; ENSONIT00000010581; ENSONIP00000010572; ENSONIG00000008409. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JNX8; -. DR OMA; FQRMIGC; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 305 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003672820. FT DOMAIN 205 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 305 AA; 35165 MW; 7140850DB909003B CRC64; MFMVTMKVII FFLILGIQGA AAVTHSLKYF YTASSQVPNF PEFVTVGMVD DVQINYYDSN TEREVPKQDW VNDAVDPQFW ERNTDISRGS QQTFKANIEI AKQRFNQTGG VHIFQQMYSC EWDDETGEVN GYEQFGYDGE DFIGFDLKTE TWVAPVQQAV ITKYKWDSNR FYTRQAKNYL TQICPEWLKK YVNYGRSSLM KTVLPSVSLL QKTPSSPVTC HATGFYPDRA EMMWKKDGEE IHEGVEIGEI LTNNDGTFQM SVNLDLRSVP AEDWRRYDCV FQFSGINENV TTTLDKTAIR TNEGK // ID I3JNY2_ORENI Unreviewed; 351 AA. AC I3JNY2; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000010576}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010576, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000010576} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01060914; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060915; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060916; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060917; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060918; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060919; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060920; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060921; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060922; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060923; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3JNY2; -. DR STRING; 8128.ENSONIP00000010576; -. DR Ensembl; ENSONIT00000010585; ENSONIP00000010576; ENSONIG00000008413. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JNY2; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 351 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003673191. FT TRANSMEM 304 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 351 AA; 39778 MW; C1A170C2FAFE1D8B CRC64; MKAFIFFLLL GIQGAAAVTH SLKYFLTGSS QVPNFPEFVV VGMVDDVQID YYDSNTEKAV PKQDWIARNT DQQYWERETA NCWGSQQSFK ANIDTAKQRF NQTGGVHIVQ RMYGCEWDDD TGEVNGYRQD GYDGEDFISF DLKTETWVAA KQQAVITKLK WDSNKATITQ YKNYLTQICP EWLKKYVNYG RSSLMKTVLP SVSLLQKSSS SSVTCHATGF YPNRAEMVWK KDGVEHHEGV NKGEILTNND GTFQMSVDLD VSSVKPEDWH RYRCVFQLSG VNEDIVTRLV KSDIKTNEGS SFSLIIPVVV AVVVLAAIAV IAFIIYKKRT DKRPPSPAEN REVQEQMLPQ A // ID I3JNY3_ORENI Unreviewed; 337 AA. AC I3JNY3; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000010577}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010577, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000010577} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01060914; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060915; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060916; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060917; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060918; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060919; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060920; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060921; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060922; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01060923; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSONIT00000010586; ENSONIP00000010577; ENSONIG00000008413. DR GeneTree; ENSGT00740000114936; -. DR OMA; HYLEEEC; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 337 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003672822. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 203 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 337 AA; 38271 MW; EF5A4823696F801B CRC64; TLALVLLIIL LIKDIGSKTF LTHSLKYFLT GSSQVPNFPE FVVVGMVDDV QIDYYDSNTE KAVPKQDWIA RNTDQQYWER ETANCWGSQQ SFKANIDTAK QRFNQTGGVH IVQRMYGCEW DDDTGEVNGY RQDGYDGEDF ISFDLKTETW VAAKQQAVIT KLKWDSNKAT ITQYKNYLTQ ICPEWLKKYV NYGRSSLMKT VLPSVSLLQK SSSSSVTCHA TGFYPNRAEM VWKKDGVELH EGVDKGEILT NNDGTFQMSV DLDVSSVKPE DWHRYRCVFQ LSGVNEDIVT RLDKSEIRTN EGNSFSLIIT VVVAVVVLAA IAVIAFIIYK KRTGEKQ // ID I3JYK5_ORENI Unreviewed; 326 AA. AC I3JYK5; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000013950}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000013950, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000013950} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01071544; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3JYK5; -. DR STRING; 8128.ENSONIP00000013950; -. DR Ensembl; ENSONIT00000013960; ENSONIP00000013950; ENSONIG00000011081. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3JYK5; -. DR OMA; THECPEW; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 239 261 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 123 211 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 326 AA; 36831 MW; CC0A528E3490369C CRC64; ETGGFVSAQQ VFKANIEIAK QRFNQTGGVH IVQRMYGCEW DDETNEVDGY EQFGYDGEDF IIFDLQTETW VAPKRQAVIT KHKWDSNKAF ITSVKNYYTQ ICPEWLKKYL NYGRSSLLRT VLPSVSLLQK SSSSAISCHA AGFYPDRAEM MWRKDGEETH EGVEIGEILT NNDGTFQMSV NLDLRSVPAE DWRRYDCVFQ FSGINENVTT TLDKTAIRTN EGKKIIRNDE DVFPISVPIS VPIVTAALVL AVVALIGFII YKKKTVTAKP SKPYTKTSPE NDPERSPSDS KPSSDITIKT ELMTSTYRLS VTHSLNLCVV LHVFTH // ID I3K3M3_ORENI Unreviewed; 158 AA. AC I3K3M3; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000015718}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015718, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000015718} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01070121; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSONIT00000015732; ENSONIP00000015718; ENSONIG00000012482. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3K3M3; -. DR OMA; NYLENLC; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352996; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}. FT DOMAIN 1 158 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 158 AA; 18266 MW; 24EA08DD42102D73 CRC64; YFYSSSSGVS NFPEFVAVGL VDDVQMIHYD SNAQKAEFKQ QWMEKAAEDD PEYSARQTNR LMNTQQVFKG NIDILKQRFN QTGGVHINQM MYGCEWDDET AEVNGYHQYG YDGEDFISFD LQTETWIAPV TQAVITKLEW DSDRSVSGDL RNYHTKLC // ID I3K3M4_ORENI Unreviewed; 365 AA. AC I3K3M4; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000015719}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015719, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000015719} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01070122; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01070123; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01070124; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01070125; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSONIT00000015733; ENSONIP00000015719; ENSONIG00000012483. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3K3M4; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 2. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003673309. FT TRANSMEM 314 337 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 204 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 41686 MW; D1501C5AEE64AED3 CRC64; IRTFMMLLLY WAASVSVSAV KHSLKYFYTA SSQVPNFPEF VVVGMVDEVQ IVQFDSNTMK TVSKQDWMNR NIDEQYWERE TGGFVSAQQV FKANIEIAKQ RFNQTGVKHS LKYFYTASSQ VPNFPEFVVV GMVDEVQILQ FDSNTMKTVS KQDWMNRNID EQYWERETGG FVSAQQVFKA NIEIAKQRFN QTGGRTVLER GFLPSVSLLQ KSSSSAISCH ATGFYPDRAE MMWRKDGEET HEGVEIGEIL TNNDGTFQMS VNLDLRSVPA EDWRRYDCVF QFSVMNEDIV TKLDKTVIRT NEGKNIIRND EEQYLNVPIV TAALVLAVVA LIGFIIYKKK TVKLFNILYF SSSDSKSSSD GSSDI // ID I3K3M5_ORENI Unreviewed; 246 AA. AC I3K3M5; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000015720}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015720, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000015720} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01070127; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3K3M5; -. DR STRING; 8128.ENSONIP00000015720; -. DR Ensembl; ENSONIT00000015734; ENSONIP00000015720; ENSONIG00000012484. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3K3M5; -. DR OMA; VEHESLL; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 200 222 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 96 183 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 246 AA; 27899 MW; A55F0DA4126C34E0 CRC64; GVHIFQTMHG CEWDDETGEV NGYMQFGYDG EDFISFDLKD QMWVAPKEQA AITKNKLDHD WALTAQYKNY FTQICPEWLK KYVNYGRSSL MRTVRPSVSL LQKSSSSSVT CHATGFYPNR AEMVWKKDGV ELHEGVNKGE ILTNNDGTFQ MSVDLDVSSV KPEDWHRYRC VFQLSGVNED IVTRLDKSEI KTNEGSSFSL IIPVVVAVVV LAAIAVIAFI IYKKRTEKRP LSPAESQEPM LPQAET // ID I3K3P1_ORENI Unreviewed; 341 AA. AC I3K3P1; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000015736}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015736, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000015736} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01068408; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01068409; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3K3P1; -. DR STRING; 8128.ENSONIP00000015736; -. DR PRIDE; I3K3P1; -. DR Ensembl; ENSONIT00000015751; ENSONIP00000015736; ENSONIG00000012499. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3K3P1; -. DR OMA; SALTKTW; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 341 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003674053. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 204 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 341 AA; 38906 MW; 5EA650DC790C32AE CRC64; MFVVTMKAII FLLFLRIRGA VAVKHSLKYF DTASSQVPNF PEFVVVGMVD DVQIVHYDSN TEKTVPKQDW FAKNTDQQYW KRETEIFRGS QQTSIANIET VKKRFNQTGG VHIVQRMYGC EWDNETGKVK GYDQHGYDGE DFALDLDTEI WIAPTPQAVT TKMKWDKNRA LIAQKKKYLT QECPEWLKKY VNYGRSSLMK TVLPSVSLLQ KSPSSPVTCH ATGFYPNRAE LVWRKDGVEL HEGVNKGEIL TNNDGNFQMS VDLDLSSVRP EDWQRYDCVF QLSGVNEDIV TKLDKAVIKT NRGKSDEVVS SAIAILIIIA TLVLAVISFI VYKKRTGERK K // ID I3K3P2_ORENI Unreviewed; 332 AA. AC I3K3P2; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000015737}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015737, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000015737} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01068408; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01068409; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSONIT00000015752; ENSONIP00000015737; ENSONIG00000012499. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 302 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 195 282 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 332 AA; 37964 MW; 0DCFC7F148C57B4A CRC64; VFLIVLIFKK KIIVKHSLKY FDTASSQVPN FPEFVVVGMV DDVQIVHYDS NTEKTVPKQD WFAKNTDQQY WKRETEIFRG SQQTSIANIE TVKKRFNQTG GVHIVQRMYG CEWDNETGKV KGYDQHGYDG EDFALDLDTE IWIAPTPQAV TTKMKWDKNR ALIAQKKKYL TQECPEWLKK YVNYGRSSLM KTVLPSVSLL QKSPSSPVTC HATGFYPNRA ELVWRKDGVE LHEGVNKGEI LTNNDGNFQM SVDLDLSSVR PEDWQRYDCV FQLSGVNEDI VTKLDKAVIK TNRGKSDEGY DLFVVVSSAI AILIIIATLV LAVISFIVYK KR // ID I3K3P4_ORENI Unreviewed; 304 AA. AC I3K3P4; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000015739}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015739, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000015739} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01068412; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01068413; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3K3P4; -. DR Ensembl; ENSONIT00000015754; ENSONIP00000015739; ENSONIG00000012501. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3K3P4; -. DR OMA; TESWIAP; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 304 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003673745. FT DOMAIN 202 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 304 AA; 34970 MW; 1DA8F8BDC12FB78F CRC64; MKLFIFLFLL EIHGTMGPTH SLRYFYTSSS GVSNFPEFVA VGLVDDVQMI HYDSNTQKAE FKQQWMEKAA EDDPEYSARQ TNRLMNTQQV FKGNIDTLKQ RFNQTGGVHI NQLMYGCDWE DETAEVNGYH LYGYDGEDFI SFDLQTETWI APKQQAVITK LKWDSDRSLS GDLKNYHTKL CPEWLKKYVN YGRSSLMRTE LPSVSLLQKS SSSPVSCHAT GFYPDRAEMV WRKDGVELHE GVNKGEILTN HDGTFQMSVD LEVSSIKSEE WHRYRCVLQL FRVNQDIVTK LGKAAIRTNE GKIG // ID I3K3P5_ORENI Unreviewed; 340 AA. AC I3K3P5; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000015740}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015740, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000015740} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01068415; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01068416; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01068417; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3K3P5; -. DR STRING; 8128.ENSONIP00000015740; -. DR Ensembl; ENSONIT00000015755; ENSONIP00000015740; ENSONIG00000012502. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3K3P5; -. DR OMA; RITQRFY; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 340 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003673856. FT TRANSMEM 311 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 38753 MW; 04660F2EB97FA808 CRC64; VWVFMVKMKA LIFVFLLGIQ GAAAVTHSLK YFYTGSSQVP NFPEFVVVGM VDDVQIDYYD SNTQKAEPRQ DWIAKNTDQQ YWERETEGFK GTQQSFKANI EILKPRFNQT GGVHIVQRMY GCEWDDDTGE VNGYRQDGYD GEDFISFDLK TETWVAPVQQ AVMTKTKWDS NKATITQYKN YLTQICPEWL KKYVNYGRSS LMKTVRPSVS LLQKSSSSSV TCHATGFYPN RAEMVWKKDG VEHHEGVNKG EILTNNDGTF QMSVDLDVSS VKPEDWHRYR CVFQLSGVNE DIVTKLDKSE IRTNEGSSFS LIIPVVVVVV VLAAIAVIAF IIYKKRTGEK // ID I3KDX9_ORENI Unreviewed; 332 AA. AC I3KDX9; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000019324}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000019324, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000019324} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01069566; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KDX9; -. DR Ensembl; ENSONIT00000019341; ENSONIP00000019324; ENSONIG00000015360. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KDX9; -. DR OMA; TCVEWLC; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT DOMAIN 203 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 332 AA; 38479 MW; 70B64F86DAE31538 CRC64; LVLVWLSSGC VHFVSERHTI TYIETAATGW NESPELTEVI FVNRQEFVHY KSSLKKMVPK TEWIEKTVDP EYWERERQRN IHSEQAIKAH VVWLMERLNQ TSVLYLSGVH ILQWMYGCEW NEDTEEVTGF EILGYDGRDY VAFDLKTETY IASAPQAVIT KHNWDRDKTR ISYKKYFLTQ ECVDKLKNFV NSGRKSLMKT VPPSVSLLQK SPSSPISCHA TGFFPNVAEM FWRKDGEELH EDVHKGEILP NNDETFQMSV DLKLSSVKPE DWERYDCVFQ FGGVNKEIVT KLDKTKIKTN TACKNTNICS IVTQFSLVLS EVLSVVLSEV LW // ID I3KDY0_ORENI Unreviewed; 308 AA. AC I3KDY0; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000019325}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000019325, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000019325} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01069566; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PRIDE; I3KDY0; -. DR Ensembl; ENSONIT00000019342; ENSONIP00000019325; ENSONIG00000015360. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}. FT DOMAIN 197 284 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 308 AA; 35665 MW; B39CEC0C9F176A9C CRC64; IVIISQKYLK RHTITYIETA ATGWNESPEL TEVIFVNRQE FVHYKSSLKK MVPKTEWIEK TVDPEYWERE RQRNIHSEQA IKAHVVWLME RLNQTSVLYL SGVHILQWMY GCEWNEDTEE VTGFEILGYD GRDYVAFDLK TETYIASAPQ AVITKHNWDR DKTRISYKKY FLTQECVDKL KNFVNSGRKS LMKTVPPSVS LLQKSPSSPI SCHATGFFPN VAEMFWRKDG EELHEDVHKG EILPNNDETF QMSVDLKLSS VKPEDWERYD CVFQFGGVNK EIVTKLDKTK IKTNTGVIGG VIGGLVVL // ID I3KDY2_ORENI Unreviewed; 293 AA. AC I3KDY2; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000019327}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000019327, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000019327} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01069569; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KDY2; -. DR STRING; 8128.ENSONIP00000019327; -. DR Ensembl; ENSONIT00000019344; ENSONIP00000019327; ENSONIG00000015362. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KDY2; -. DR OMA; VTHHPVF; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}. FT DOMAIN 161 265 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 293 AA; 33829 MW; 0CEB8509FF0DA2A7 CRC64; HSLKYFYTAI SQVPNFPEFV VVGMVDEVQM VQFDSNTMKT VSKQDWMNRN IDEQYWERET GGFVSAQQVF KANTEIAKQR FNQTGGVHIV QQMYGCEWDD ETNEVDGYEQ FGYDGEDFIT FDPQTETWVA PKQQAVVTKH KWDSNKAFIT SVKNYYTQIC PEYLNYGRSS LMRTVLPSVS LLQKSSSSAI SCHVTGFYPD RAEMIWRKDG EETHEGVEIG EILTNNDGTF QMSVNLDLRS VPAEDWRRYD CVFQFSGINE NVTTTLDKTV IRTNEGKNII RNDEDVLFVL FCV // ID I3KLD3_ORENI Unreviewed; 281 AA. AC I3KLD3; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000021928}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021928, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000021928} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01059077; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KLD3; -. DR STRING; 8128.ENSONIP00000021928; -. DR Ensembl; ENSONIT00000021947; ENSONIP00000021928; ENSONIG00000017388. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KLD3; -. DR OMA; CEGETHP; -. DR OrthoDB; EOG091G0BBK; -. DR TreeFam; TF334519; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}. FT DOMAIN 24 208 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 216 279 IGc1. {ECO:0000259|Pfam:PF07654}. SQ SEQUENCE 281 AA; 32629 MW; 461AEB931BAA307B CRC64; SSFFNVLFSA TVTRVCSFMQ TTETHSLHYI YTALSKPVGL PGIHEFTAMG LLDNRMIDYF DSKNQVKVPR QEWMRKRLPA DYWEKGTQSR KSKQQWFKVN IGILMERMRQ NESDTPHVLQ WMHGCEGETH PDGTLKFVRG MDMYNYDGND FLSFDDKNGV WVAPIDEALP TKRKWDGVQV LKEYTKGYLE NECIDWLSKF VTYGQQQLKK KSPPEVFVFA KKSKVESNLI LTCLATGFYP KDIIMRIRRN GRVLTADDGL TSSGVLPNND ETFQRRDHVE I // ID I3KLD4_ORENI Unreviewed; 269 AA. AC I3KLD4; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000021929}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021929, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000021929} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01059093; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01059094; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01059095; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KLD4; -. DR STRING; 8128.ENSONIP00000021929; -. DR Ensembl; ENSONIT00000021948; ENSONIP00000021929; ENSONIG00000017389. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KLD4; -. DR OMA; AYLEENC; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF334519; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}. FT DOMAIN 13 196 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 213 268 IGc1. {ECO:0000259|Pfam:PF07654}. SQ SEQUENCE 269 AA; 30927 MW; 69794FCE5834B04B CRC64; GLRHQLSAIY NQTHSLHYIY TALSKPVGLL GIHQFTAMGL LDGRMIDYFD SENQAKVPKQ EWMRERLPAD YWERGTRSRK SKQQWFKVNI GILMERMRQN DSDIHVLQWM HGCEGEANPD GTLRFVRGMD MYAYDGDDFL SFDDKNGVWV APSPEAEPTK RKWDGVLVLK EYTKGYLENE CIDWLSKFVT YGQQQLQNTS PPEVSLHAKT STVDTDVLLT CLATGFYPAD IVLRMKKNES VLTADDGLMS SGVLPNEDHT FQRRDHVEV // ID I3KLD5_ORENI Unreviewed; 403 AA. AC I3KLD5; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000021930}; GN Name=LOC100689711 {ECO:0000313|Ensembl:ENSONIP00000021930}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021930, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000021930} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01059099; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01059100; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01059101; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01059102; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01059103; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_013122562.1; XM_013267108.2. DR STRING; 8128.ENSONIP00000021930; -. DR Ensembl; ENSONIT00000021949; ENSONIP00000021930; ENSONIG00000017390. DR GeneID; 100689711; -. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KLD5; -. DR OMA; SCEVIHE; -. DR OrthoDB; EOG091G0BBK; -. DR TreeFam; TF334519; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 403 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003674657. FT TRANSMEM 315 337 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 403 AA; 44222 MW; BDE8A0259721AB74 CRC64; MNLFAVFVLL GTVLTVNCET HSLHYIYTAL SKPVGLPGIH EFTAMGLLDD RMIDYFDSEH QAKVPKQEWM EKRLPADYWE KGTQSRKSKQ QWFKVNIGIL MERMRQNDSD NHVLQWMHGC EGETNPDGTL GFVRGMDMYN YDGNDFLSFD DKNGVWVATT PEAQPTKRKW DGVQVLKEYT KGYLENECID WLSKFVTYGQ KQLKKKSPPD VHVFTKKAKV ESNLILTCLA TGFYPKDIIV KIRRNGRVLT ADDGLTSSGV LPNNDETFQR RDHVEILKSD LSEFSCEVIH EATGVDVAKT WTNKCEEVSG SGSGALIGGA VVGVVVVVAV AVGLILYKMG IIGGRRGAKD NQGGIQTIYS PVTVGNGVVS TPLTSGGSNG NAASSNGGSN GHATVPLLNG NAH // ID I3KLD6_ORENI Unreviewed; 352 AA. AC I3KLD6; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000021931}; GN Name=LOC100689711 {ECO:0000313|Ensembl:ENSONIP00000021931}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021931, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000021931} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01059099; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01059100; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01059101; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01059102; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01059103; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSONIT00000021950; ENSONIP00000021931; ENSONIG00000017390. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 352 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003674236. FT TRANSMEM 319 341 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 213 306 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 352 AA; 39902 MW; 859B65CAA3CD80D1 CRC64; MLLFGFFFVF YLFLSKSVWW MHETHSLHYI YTALSKPVGL PGIHEFTAMG LLDDRMIDYF DSEHQAKVPK QEWMEKRLPA DYWEKGTQSR KSKQQWFKVN IGILMERMRQ NDSDNHVLQW MHGCEGETNP DGTLGFVRGM DMYNYDGNDF LSFDDKNGVW VATTPEAQPT KRKWDGVQVL KEYTKGYLEN ECIDWLSKFV TYGQKQLKKK SPPDVHVFTK KAKVESNLIL TCLATGFYPK DIIVKIRRNG RVLTADDGLT SSGVLPNNDE TFQRRDHVEI LKSDLSEFSC EVIHEATGVD VAKTWTNKCE EVSGSGSGAL IGGAVVGVVV VVAVAVGLIL YKMGIIGKSS VL // ID I3KP62_ORENI Unreviewed; 394 AA. AC I3KP62; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000022907}; GN Name=LOC100696765 {ECO:0000313|Ensembl:ENSONIP00000022907}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000022907, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000022907} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01050938; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01050939; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSONIT00000022927; ENSONIP00000022907; ENSONIG00000018185. DR GeneTree; ENSGT00740000114936; -. DR TreeFam; TF334519; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 394 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003674082. FT TRANSMEM 324 343 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 213 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 394 AA; 44584 MW; 644A31862B7D6AA1 CRC64; ISIYLLLFSV VYLFSVPPSW FKKHSLHYIY TGLSKPVGLP GIHEFTAMGL LDGRMIDYYD SENQTKVPKQ EWMREHLPAD YWVKGTQSRR IKQRWFKHNI GILMERMRKN DSGSPHVLQW MVGCEGEMQP NGALRFVRGM SKYNYDGNDF LSFDDKNRVW VAPVKEALPS KTKWDNDQVL KEYTKGYLEN ECIDWLSKSV TSEQKQLKKA PPPGVYVFAK KSRVETNLTL TCLATGFYSK NIILRIRRKG RVLTEDDGLW SSGVLPNDDE TFQRRDYVEI LKSDLSEFSC EVVHEATRVD VVKTWKNGDH PEEPGSGALI GAQGGALAVI ALVVGGGLGL ICLHKKGRLS KYRSVAVVVT NVEADSEKVE EDEGNEDEAE ETSLRSSTGK FSSA // ID I3KP63_ORENI Unreviewed; 415 AA. AC I3KP63; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000022908}; GN Name=LOC100696765 {ECO:0000313|Ensembl:ENSONIP00000022908}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000022908, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000022908} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01050938; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01050939; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_003458512.1; XM_003458464.4. DR STRING; 8128.ENSONIP00000022908; -. DR Ensembl; ENSONIT00000022928; ENSONIP00000022908; ENSONIG00000018185. DR GeneID; 100696765; -. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KP63; -. DR OrthoDB; EOG091G0BBK; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 415 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003674762. FT TRANSMEM 321 340 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 415 AA; 46585 MW; 79AE67065BD0CE5C CRC64; MFVISVLVLV GTGVTVNSEK HSLHYIYTGL SKPVGLPGIH EFTAMGLLDG RMIDYYDSEN QTKVPKQEWM REHLPADYWV KGTQSRRIKQ RWFKHNIGIL MERMRKNDSG SPHVLQWMVG CEGEMQPNGA LRFVRGMSKY NYDGNDFLSF DDKNRVWVAP VKEALPSKTK WDNDQVLKEY TKGYLENECI DWLSKSVTSE QKQLKKAPPP GVYVFAKKSR VETNLTLTCL ATGFYSKNII LRIRRKGRVL TEDDGLWSSG VLPNDDETFQ RRDYVEILKS DLSEFSCEVV HEATRVDVVK TWKNGDHPEE PGSGALIGAQ GGALAVIALV VGGGLGLICL HKKGRLRGRR VANDNQGSVA VVVTNVEADS EKVEEDEGNE DEAEETSLRS STADGSDKKT RLRIHTKSSA TENMD // ID I3KPI1_ORENI Unreviewed; 355 AA. AC I3KPI1; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000023026}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023026, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000023026} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01072545; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01072546; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KPI1; -. DR STRING; 8128.ENSONIP00000023026; -. DR Ensembl; ENSONIT00000023046; ENSONIP00000023026; ENSONIG00000018290. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KPI1; -. DR OMA; KTHITHY; -. DR OrthoDB; EOG091G0BU8; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 296 318 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 185 272 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 355 AA; 40406 MW; E88B2FBD4F027DF1 CRC64; LTVTHSLKYF YTGSSQVPNF PEFVTVGMVD DVQIEYYDSD TEKAVPKQDW FARNTDQQYW ESQTGLFKGT QQTFKANIEI LKQRFNQTGG VHINQVMYGC EWDEETGEVN GYRQEGYDGE DFISFDLKEE TWVAAKQQAV MTKIKLDHDW ALTAQRKNYL TQICPEWLKK YVNYGRSSLM KTIVPKVSLL QKTPSSPISC HATGFFPNVA EMFWRKDGEE LHEGVHKGEI LPNNDETFQM SVDLKLSSVK PEDWERHECV FQFGGVNKEI VTKLDKTKIK TNTGKTDIVV SGPSGFHVGG VIGGLAVLLL AVCIGIYFKL RGNGNEQNIF LCFMNDIHGL IVQTVNRRAV KSRQP // ID I3KQ29_ORENI Unreviewed; 346 AA. AC I3KQ29; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000023224}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023224, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000023224} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01062919; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KQ29; -. DR Ensembl; ENSONIT00000023244; ENSONIP00000023224; ENSONIG00000018447. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KQ29; -. DR OMA; ELLEWHT; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 6 25 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 318 340 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 213 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 346 AA; 39683 MW; 9146690D14A4FB2D CRC64; IKELDIVLLF LHFIYLITNI INISCPTVRH TMKYFITGSS GVPNISELVG AGLVDDIPMC YCDGSNKVLE PRQDWVKNML KNNSELLEWH TEQCFKYLPD FFRALIIRLK QQFNQTGGVH VIQRIESCDW DEDTGEVTGL IQYGYNGEGF LEFDLKTLSW IALKPEADLI KQRWDADKDS NKDNEIFLTE KCPEGLKMYL DYGKSYLQRK VRPSVFLLQK TPSSPVSCHA TGFYDRAILS WRKDGKQLQE GMDNGEILPN NDGTFQMSVN LNVSSVRPED WNRYDCVFQV SDVDQKIVNK LDKTLIRTNW GKKHSKEVIP IILVVLVLVV IIAAVGFAVY KKKKGK // ID I3KS13_ORENI Unreviewed; 268 AA. AC I3KS13; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000023909}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023909, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000023909} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01072749; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01072750; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01072751; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KS13; -. DR PRIDE; I3KS13; -. DR Ensembl; ENSONIT00000023930; ENSONIP00000023909; ENSONIG00000018989. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KS13; -. DR OMA; LENECTQ; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 218 243 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 119 192 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 268 AA; 30412 MW; 58058542394E31E1 CRC64; FVTLPNLFRA WIFGLQQQFN QPGGIHILQS ISGCEWDEST GEMINFLRYA YNGEDFLEFD MKTLTWIALK PEAVNTKQRW DTDENRIKYT VEFFSTTCPK WLKMSLESGK RSLQRTVLPS VSLLQKSSSS PVSCHATGFY PQRAVMFWRK DGEEIHDGVD SGEILPNNDE TFQMCVDLNV SVRPEDWSRY DCVFQLSDGD DIITKLDKKV IRTNCGKIIP VIGGTAVTVG KMNVLIFLIG VIVSVKKKAE NCKICDMSVA NKKLTQLT // ID I3KVM6_ORENI Unreviewed; 100 AA. AC I3KVM6; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000025172}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025172, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000025172} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01048721; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSONIT00000025193; ENSONIP00000025172; ENSONIG00000019989. DR GeneTree; ENSGT00910000145975; -. DR InParanoid; I3KVM6; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}. FT DOMAIN 17 99 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 100 AA; 11867 MW; 5F7FD598D9532B48 CRC64; MVDGIQVGYC DVSKKILEPR QEWAKNILEK HPEQLGWYKH KCFEHQPNFF RELISSLKQQ FNQSEGVHIL QRIDGCEWDE TTGEVIGIIQ YHYNGEDFLE // ID I3KVM7_ORENI Unreviewed; 251 AA. AC I3KVM7; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000025173}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025173, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000025173} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01048727; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KVM7; -. DR Ensembl; ENSONIT00000025194; ENSONIP00000025173; ENSONIG00000019990. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KVM7; -. DR OMA; EPITIRW; -. DR OrthoDB; EOG091G1VY3; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}. FT DOMAIN 15 190 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 208 251 IGc1. {ECO:0000259|Pfam:PF07654}. SQ SEQUENCE 251 AA; 29068 MW; A6A8EDBB7ADAACE9 CRC64; SGFLAMLVWR PVSSKHSLKY LLTETPGAQS IPEFVCVGFI DDVQFGSWNS RGGEKVEKDW IKFFEDEPQL RQDYISTCST THYYFKETIR TLKQHLNQNE AGVHVLQRVS GCEWDNETGE VNGYNQYGYD GEDFIAFDLQ TATWITSNRQ AETTKLKWNT ERARLEYNKN FVIYLCPEFL KRHLNYGRSF LEEEILPSVS LLQKTLSSPV SCHATGFYPH RAVIFWRKDG EELHESVDPG QILPNDDGTF Q // ID I3KVM8_ORENI Unreviewed; 354 AA. AC I3KVM8; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000025174}; GN Name=LOC100699341 {ECO:0000313|Ensembl:ENSONIP00000025174}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025174, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000025174} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01048732; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01048733; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSONIT00000025195; ENSONIP00000025174; ENSONIG00000019991. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KVM8; -. DR OMA; NTENPEY; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 354 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003674680. FT TRANSMEM 305 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 354 AA; 40531 MW; 5700B0060A312D38 CRC64; MNSVLILLLC CHVASPVKHS LKYFFTESPG AQSIPEFVAV AIVDDVQIGD SNSVREATPK KDWIKFFEDH PQHLEWYSLQ SHDSHHFFKA TIETLRQRLN QTEGVHILQR MKGCEWDDET GEINGYDQYG YDREDFLVYD LKTLTWIAPK PHAVLTKMRF DAHEHQFESN KNFLVYQCPD FLKEYLRYGK RFLQTAVLPS VSLLQKTPSS PVSCHATGLY PDRAEMFWRK DGEELHEGVD PGEILLNNDG TFQMSVDLNV SSVMPEDWQR YDCVFQLSGV NEHIITKLEK TLIKTNWAEK PTDTVTFISA AVIVLAVTII TAVAFVTYKM KKGEKSECAP DDGSEQSERL NPQS // ID I3KVM9_ORENI Unreviewed; 327 AA. AC I3KVM9; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000025175}; GN Name=LOC100699341 {ECO:0000313|Ensembl:ENSONIP00000025175}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025175, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000025175} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01048732; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01048733; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSONIT00000025196; ENSONIP00000025175; ENSONIG00000019991. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 297 318 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 184 271 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 327 AA; 37678 MW; 9DF66355494D86BF CRC64; TVKHSLKYFF TESPGAQSIP EFVAVAIVDD VQIGDSNSVR EATPKKDWIK FFEDHPQHLE WYSLQSHDSH HFFKATIETL RQRLNQTEGV HILQRMKGCE WDDETGEING YDQYGYDRED FLVYDLKTLT WIAPKPHAVL TKMRFDAHEH QFESNKNFLV YQCPDFLKEY LRYGKRFLQT AVLPSVSLLQ KTPSSPVSCH ATGLYPDRAE MFWRKDGEEL HEGVDPGEIL LNNDGTFQMS VDLNVSSVMP EDWQRYDCVF QLSGVNEHII TKLEKTLIKT NWGKTDKPEK PTDTVTFISA AVIVLAVTII TAVAFVTYKM KKGEKSE // ID I3KVN0_ORENI Unreviewed; 328 AA. AC I3KVN0; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000025176}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025176, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000025176} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01048733; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KVN0; -. DR Ensembl; ENSONIT00000025197; ENSONIP00000025176; ENSONIG00000019992. DR eggNOG; ENOG410KF51; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KVN0; -. DR OMA; LENECIE; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 303 324 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 197 271 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 328 AA; 37939 MW; E4FC472848C05C1E CRC64; QCHLIQSLII VTVKHSLKFF FTQTSGVQSI PEFVVVGLVD EVQGGYYESN TGRPEPKTEW MKKLMKDDPQ HLEWYTTQSL DLKHLFKHYI EDLRKRFNQT RGIHILQKLD GCEWDDETGE VNGFNQYGYD GDDFLTFDPQ RLIWIALKPQ AVITKLRWDG EKERLQYNKN FYVHECPEFL KKYVQYGKDF LQTPGFPSVS LLQKTPSSPV SCHATGFYPD RAEMFWRKDG EELHEGVDPG EILPNNDDTF QLSVDLNVSS VTPEDWQRYD CVFQLSGVNE YMMTKLDKAA IRTNRGKRIV SQVQTSIVLI ATAAVGAAVV FVTYKRKK // ID I3KVN2_ORENI Unreviewed; 318 AA. AC I3KVN2; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000025178}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025178, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000025178} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01048737; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KVN2; -. DR Ensembl; ENSONIT00000025199; ENSONIP00000025178; ENSONIG00000019994. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KVN2; -. DR OMA; ISMENEC; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 293 317 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 157 268 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 318 AA; 36323 MW; 42F72FD869363094 CRC64; TVKHSLKYFI TESPGAQSIP EFVAVAFVDE VQIGDFNVRG AKPKKDWIKF FEDNPQHLEW YTLRCLNRHH FLKATIESLR QRLNQTEGVH ILQKLDGCEW DDETGEVNGF NQYGYDGEDF LAFDLQTMTW ITAKPHAVST KMIWDADKFL SDNVILPIVC RKLFCKYFFK NSSYYLFAVL PSVSLLQKSS PFLISCHATG FFPNRGMMFW RKDGEELHEG VDPGEILPNN DGTFQMSVDL KLSSVTPKDW QRYDCVFQLS GVNEDIVTKL HKTVIRTNWG KTGSCRTEKP TDAVTFISAA VVVLTVTIIT AVAFVTYK // ID I3KVN5_ORENI Unreviewed; 267 AA. AC I3KVN5; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000025181}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025181, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000025181} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01048737; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01048738; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KVN5; -. DR Ensembl; ENSONIT00000025202; ENSONIP00000025181; ENSONIG00000019996. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KVN5; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 230 253 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 125 212 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 267 AA; 30741 MW; D773887A0AA16A01 CRC64; EWYRLKSVDR HHFLKATIET LRQRLNQTEG VHILQKLDGC EWDDETGEIN GFNQYGYDGE DFLALDLQTL TWIAAKPQAV ITKIKWDAQK GRVEENKNFF VDQCPEFLKE YLRYGRRFLQ TTVLPSVSLL QKTPSSPVSC HATGFYPDRA VMFWRKDGEE LHEGVDPGEI LPNNDDTFQL SVDLNVSSVT PEDWQRYDCV FQLSAVKEHI VTKLDKTMIR TNWEKPADTV TFISAAVVVL TVTIITAVAF VTYKKNYASD NDRSHDP // ID I3KVN7_ORENI Unreviewed; 320 AA. AC I3KVN7; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000025183}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025183, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000025183} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01048746; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KVN7; -. DR Ensembl; ENSONIT00000025204; ENSONIP00000025183; ENSONIG00000019998. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KVN7; -. DR OMA; GCEWNDE; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 295 317 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 187 274 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 320 AA; 36718 MW; 95AE00AD5795625A CRC64; CPANFTVKHS LKFFSTQTSE SIPEFSAGAL VDEVQIGDFN SVRGAELKKD WIKFFEDHPW HLEWYSFQSN DSHQFFKATI ETLRQRFNQT EGVHIMQRMN GCEWNDETGE INGFNLYSYD GEDFLALDLQ TLTWITPKPQ AVLTKLRWDA QKDRLKLNKT FLGHLCPEFL KEYLQYGRSF LQTAVLPSVS LLQKTPSSAI SCHATGFYPD RAVMFWRKDG EEIHEGVDPG EILPNNDGTF QLSVDLKLSS VTPEDWQRYD CVFQFSGVNE YIITKLDKTA IRTNWAEKPT DMGTFIGAAV IVLAFTIITA VTFLTYINKK // ID I3KVN8_ORENI Unreviewed; 210 AA. AC I3KVN8; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000025184}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025184, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000025184} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01048755; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSONIT00000025205; ENSONIP00000025184; ENSONIG00000019999. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KVN8; -. DR OMA; DWINTYM; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}. FT DOMAIN 170 210 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 210 AA; 24179 MW; FD0B9F8B12149F89 CRC64; ISEFVGFPVI DGIQMAYYCD SSNKILEARQ DWAKKILDTN PQMLESLTDY CFVDRPNLFR LWISSLKQQL NQSRAVHILQ MIEGCEWDEN TGEVTGLLQY GYDGEDFLKL DLKTLTWIAL KPEADIIKQS WDADTTRMKD REKILTKICP EWLKMYVDSG NSSLQRTVLP SVSLLQKTPS SPVSCHATGF YPDRAVMFWR KDGEELHEGV // ID I3KVP0_ORENI Unreviewed; 322 AA. AC I3KVP0; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 23-MAY-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000025186}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025186, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000025186} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01048783; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KVP0; -. DR Ensembl; ENSONIT00000025207; ENSONIP00000025186; ENSONIG00000020001. DR GeneTree; ENSGT00910000145975; -. DR InParanoid; I3KVP0; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 322 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003675045. FT DOMAIN 196 270 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 322 AA; 38040 MW; 36485F6E127ED22D CRC64; LKSILFLFIY LFHAVKHSLK LIFIESSGVQ DFVGVLWADE TELVHCNTNL NKAEPKPNWL KEFMKSNQEH NDLYTQECLH SQHFFKDTLN VLRRSCSQTE GVHTLQRMYG CEWDNETEEV KSFDRYGYDG EDLMEFNQET QTWLISTPCA SIVKHKLDNQ QIRIADINHY LTNVCSKWLK KYLDYGKYFL QRTDWPSVSL LQKTPSSSVS CHATGFYPDR AVMFWRKDGK KLYQFTDREQ IYPNQDRTFQ INVVLKLSSV TSEDWSRYDC VFQLSAVKED IIIKLDQKVI KSNRGKSEPK IMDLVCVFRT RSWESNNFKP KK // ID I3KVP5_ORENI Unreviewed; 324 AA. AC I3KVP5; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000025191}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025191, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000025191} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01048786; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KVP5; -. DR Ensembl; ENSONIT00000025212; ENSONIP00000025191; ENSONIG00000020006. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KVP5; -. DR OMA; FARIVDC; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 324 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003674682. FT DOMAIN 203 277 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 324 AA; 36701 MW; F27A7BD765A80162 CRC64; MKPVYLLLLC SNVVCLVKHS LVSFDTGSSG NPNISEFVGF PVIDGIQMAY YCDSSNKILE PRQDWAKKIL DTNPQMLESL TDYCFVDRPN LFRLWISSLK QQLNQNRAVH ILQMIEGCEW DENTGEVTGL LQYGYDGEDF LKLDLKTLTW IALKPEADII KQSWDADTTR MKDREKILTK ICPEWLKMYV DSGNSSLQRT VLPSVSLLQK TPSSPVSCHA TGFYPNTAVM FWRKDGEELH EGVDPGEILP NNDGTFQMSV DLNVSSVTPE DWGSYDCVFQ LSGGEDILVT KLNKTVIRTN WGKKIFNTDE GERNISFARI VDCL // ID I3KVW0_ORENI Unreviewed; 353 AA. AC I3KVW0; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000025256}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025256, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000025256} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01048807; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01048808; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KVW0; -. DR STRING; 8128.ENSONIP00000025256; -. DR Ensembl; ENSONIT00000025277; ENSONIP00000025256; ENSONIG00000020051. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KVW0; -. DR OMA; RKWEALG; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 353 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003675073. FT TRANSMEM 306 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 353 AA; 39930 MW; 750F84EC50715466 CRC64; MKVFIFFLLL GIQGAAAVTH SLKYFYTGSS QVSNFPEFVA LGMVDDVQID YFDSNTQKKV PKQDWMNDAV DPQYWERGTA SRMSKQQVFK ANIEIAKQRF NQTGGVHIFQ LMYGCEWDDE TKELGGYYQF GYDGEDFISL DLPTTHWTAA KQQAVITKQK WDTNGFAVSE KNYVSTICPD WLKKYVSYGS SSLMRTERPS VSLLQKSSSS PVTCHATGFH PNRAEMVWKK DGMELHEGVD KGEIITNNDG TFQMSVHLDV SSIKPEDWKK YDCVFQLSGM NEDIVTKLNK SDIKTNESKT GIRKSYLIMI IAIVVVVVVL AAVIGIIVYK KKTSRCSQPP MKEPEVVKPL NPP // ID I3KVW8_ORENI Unreviewed; 349 AA. AC I3KVW8; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000025264}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025264, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000025264} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01048818; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01048819; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KVW8; -. DR STRING; 8128.ENSONIP00000025264; -. DR Ensembl; ENSONIT00000025285; ENSONIP00000025264; ENSONIG00000020058. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KVW8; -. DR OMA; RMANEDW; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 349 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003675055. FT TRANSMEM 307 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 303 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 349 AA; 39757 MW; 01B084B99C355439 CRC64; LLKVWMFMVT MKAFIFFLLL GIQGAAAVTH SMKYFYTASS QVPNFPEFVA VGMVDDAQMV YYDSNTEKAV PKQDWVNDAA DPQYWERNTG NFRGAQQVFK ANIEILKPRF NQTGGVHLYQ WMYGCEWDDE TNEVKGFEQD GYDGKDFLSF DMKTETFITP VPQAIVTKHK LESNRGFIAQ KVNYLTQICP DWLKKYVSYG RSSLMRKVLP SVSLLQKTSS SQFHCHATGF YPNRAEMFWR KDGEEHHEGV VKGEILPNND GTFQMSVDLD LSSVTPEDWD KYDCVFQLSG VNEDIVTRLN KVTKKEFPVG VVVGVIAGLL LLAVIAGVYM WQKKYKGFKP TNTSDTSST // ID I3KVX3_ORENI Unreviewed; 208 AA. AC I3KVX3; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000025269}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025269, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000025269} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01048828; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01048829; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KVX3; -. DR Ensembl; ENSONIT00000025290; ENSONIP00000025269; ENSONIG00000020061. DR GeneTree; ENSGT00740000114936; -. DR TreeFam; TF352993; -. DR Proteomes; UP000005207; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}. FT DOMAIN 168 208 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 208 AA; 24116 MW; ED9DF6CFE9823FB1 CRC64; FPEFVAVGLV DDVQMIHYDS NTQKAEFKQQ WMEKAAEDDP EYLSRQTNRL MNTQQVFKGN IDILKQRFNQ TGANHLFKRM YGCEWDNETG KVKGYDQHGY DGEDFVALDL DTEIWIAPTP QAVTTKMKWD KNRALIAQKK NYLTQECPQW LKKYVNYGRS SLMKTVPPSV SLLQKSPSSR VTCHATGFYP NRAELVWRKD GVELHEGV // ID I3KVX4_ORENI Unreviewed; 306 AA. AC I3KVX4; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000025270}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025270, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000025270} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AERX01048828; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AERX01048829; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3KVX4; -. DR Ensembl; ENSONIT00000025291; ENSONIP00000025270; ENSONIG00000020061. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3KVX4; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 277 298 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 183 251 IGc1. {ECO:0000259|SMART:SM00407}. SQ SEQUENCE 306 AA; 35196 MW; DC10E74E6C1E2044 CRC64; NFPEFVAVGL VDDVQMIHYD SNTQKAEFKQ QWMEKAAEDD PEYLSRQTNR LMNTQQVFKG NIDILKQRFN QTGGVHINQM MYGCEWDDKT TVVNGYHYFG YDGEDFILFD LKTDTWIAPV MQAVITKLKW DSDGSLSGDL RNYRTKLCPE WLKKYVNYGR SSLMRTELPS VSLLQKSSSS PVHATGFYPD RAEMVWRKDG VEIHEGVNKG EILTNNDGTF QMSVDLDVSS VKPEDWHRYR CVFQLSGVNE DIVTKLGKAA IRTNEGKIGK RIFPAGVVIR IMGILLLLTL CFSGIFIWRR KYKGEK // ID I3LB82_PIG Unreviewed; 344 AA. AC I3LB82; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 12-SEP-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000021301}; GN Name=TRIM52 {ECO:0000313|Ensembl:ENSSSCP00000021301}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000021301, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000021301} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000021301}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Proteomes:UP000008227}; RA Zha H.-G.; RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSSSCP00000021301} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [4] {ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Proteomes:UP000008227}; RG International Swine Genome Sequencing Consortium; RA Warr A., Hall R., Kim K., Koren S., Phillippy A.M., Bickhart D.M., RA Rosen B., Schroeder S., Hume D.A., Talbot R., Chow W., Howe K., RA Nonneman D.J., Rohrer G.A., Watson M., Smith T.P., Archibald A.L.; RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Proteomes:UP000008227}; RA Warr A., Hall R., Kim K., Koren S., Phillippy A.M., Bickhart D.M., RA Rosen B., Schroeder S., Hume D.A., Talbot R., Chow W., Howe K., RA Nonneman D.J., Rohrer G.A., Watson M., Smith T.P., Archibald A.L.; RT "Exploiting long read sequencing technologies to establish high RT quality highly contiguous pig reference genome assemblies."; RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000010; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3LB82; -. DR STRING; 9823.ENSSSCP00000021301; -. DR PaxDb; I3LB82; -. DR PRIDE; I3LB82; -. DR Ensembl; ENSSSCT00000030544; ENSSSCP00000021301; ENSSSCG00000035650. DR eggNOG; ENOG410IGE3; Eukaryota. DR eggNOG; ENOG41114P3; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3LB82; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008227; Chromosome 2. DR Bgee; ENSSSCG00000021378; Expressed in 5 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 300 320 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 203 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 344 AA; 39342 MW; D4404D5287C71AFF CRC64; MAKVVMAELA DLKLEKKPWP RGTHSLRYHY LALSEPGPGL PQFLAVGYVD DQVFIRYDSR RGKAEPQAPW MAHMDAQYWE KETKKQRIWA KVQQVEMWTV MGYYNQSSGM HSTQRMFGCE IQEDGHSTGF WQFGFDGQDH LSLDLETLSW VSAEPVAVRT KRWWETERCY AEYDKAYVEG VCLTSLRKYL ELGGQRFSRR EPPTVRVTKH TAQDGGTTLR CWALGFYPQD ISLSWWLGEK ELTSKTEYVE TRPSGDGTYQ TWLATQVPAG EEIQYTCHVQ HSSLNHTLTV TWESPSSSGL IAMIISPILV LLVVCVVILI KCLQGGEDPY NCQSPARTEP TQLI // ID I3LYH2_ICTTR Unreviewed; 242 AA. AC I3LYH2; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000001240}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000001240, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000001240} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000001240} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01021706; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01021707; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01021708; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01021709; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3LYH2; -. DR Ensembl; ENSSTOT00000001383; ENSSTOP00000001240; ENSSTOG00000001385. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; I3LYH2; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 220 241 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 23 190 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 242 AA; 27528 MW; C8441330E38895F3 CRC64; MGRGCLKGPF SPAQPYSPFS LTGTHSLCYD FTINSKAAPG QQWCMIQGQV DHKNFLSYDC GLDKIKSLSA LGGKISATIT WEEQKATLRD MGDMLKQKLD DTKAENDMAK GLHTLEGRMC CRLKSSGCTS GSWQFGFNGR MRLRFDSDNK RWTVVHPGSN WMKEKWEDDR EMTKFLHKTS MGDCRTWLQN LKEWEAELEP TGPSITNPDR VFQESAAIAL IPWALLWILT YFIHLGLQIF LT // ID I3LYH6_ICTTR Unreviewed; 242 AA. AC I3LYH6; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000001245}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000001245, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000001245} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000001245} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01021706; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01021707; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01021708; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01021709; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3LYH6; -. DR Ensembl; ENSSTOT00000001389; ENSSTOP00000001245; ENSSTOG00000001385. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; I3LYH6; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 222 241 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 23 190 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 242 AA; 27335 MW; 1C0956D9E5C2767F CRC64; MGRGCLKGPF SPAQPYSPFS LTGTHSLCYD FTINSKAAPG QQWCMIQGQV DHKNFLSYDC GLDKIKSLSA LGGKISATIT WEEQKATLRD MGDMLKQKLD DTKAENDMAK GLHTLEGRMC CRLKSSGCTS GSWQFGFNGR MRLRFDSDNK RWTVVHPGSN WMKEKWEDDR EMTKFLHKTS MGDCRTWLQN LKEWEAELEP TGPSTTTPDT VLEKSSASTF NHWNSVPLIT IILIIGCIII FF // ID I3LYM2_ICTTR Unreviewed; 343 AA. AC I3LYM2; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 43. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSSTOP00000001308}; GN Name=MR1 {ECO:0000313|Ensembl:ENSSTOP00000001308}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000001308, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000001308} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000001308} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01014874; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01014875; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005319790.1; XM_005319733.2. DR ProteinModelPortal; I3LYM2; -. DR STRING; 43179.ENSSTOP00000001308; -. DR Ensembl; ENSSTOT00000001461; ENSSTOP00000001308; ENSSTOG00000001462. DR GeneID; 101972633; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3LYM2; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 343 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5011516970. FT TRANSMEM 294 318 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 343 AA; 39730 MW; C68C315829828E05 CRC64; MVLLVPLITV FMVKLSHART HSLRYFRLGV SDPGHGVPEF VSVGYVDSHP ITIYDSVTRQ KEPRAPWMAE NLAPDHWERY TQLLRGWQQM FKVELRHLQR HYNHSGLHTY QRMIGCELLE DGSTTGFLQY AYDGQDFIVF NKDTLSWMAV DNVAHITKRA WEANQHELQY QKNWLEKECI AWLKRFLEYG KDTLLRTEPP LVRISRKEFF PGITTLFCRA HGFYPPEISI IWKKNGEELV QEVDYADILP SGDGTYQTWV SVELDPQSRD IYSCHVEHCG LHMVLQGHQE SESILLVMKA VFGAIALTLV LTGVGFLARR RRPREHNGVI DPSTCIRECS SRS // ID I3MN99_ICTTR Unreviewed; 365 AA. AC I3MN99; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 41. DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSSTOP00000013102}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSSTOP00000013102}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000013102, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000013102} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000013102} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01089705; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01089706; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005336736.1; XM_005336679.2. DR RefSeq; XP_013218988.1; XM_013363534.1. DR STRING; 43179.ENSSTOP00000013102; -. DR Ensembl; ENSSTOT00000014625; ENSSTOP00000013102; ENSSTOG00000014628. DR GeneID; 101960419; -. DR CTD; 2217; -. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3MN99; -. DR OrthoDB; EOG091G0KJB; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019864; F:IgG binding; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. SQ SEQUENCE 365 AA; 39886 MW; 697512DE59124C5A CRC64; MGVPWPQPWA LGLLLFLLPQ TRGAENHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLS YSSLRAEAEP CGAWVWENQV SWYWEKETTD LRNKEKLFLD ALAALGRKGS YTLQGLLGCE LGPDNVSVPT ATFALNGEEF MRFDPKNGNW TGDWPEAQTI SEKWMQQAEA VGKERTFLLN SCPQRLLGHL ERGRVNLEWK EPPSMRLKAR PSSPGFSVLT CSAFSFYPPE LQLRFLRNGL AAGSGEGGFG PNGDGSFHAW SSLIVKSGDE HHYCCIVQHA GLAQPLTVEL ESPAKSSVPV VGIIIGFLLL TAVAAGGALL WRRMRNGLPA PWISFRGDDV GALLPTPGLP EDADCQDINS FPATA // ID I3MPL1_ICTTR Unreviewed; 376 AA. AC I3MPL1; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 23-MAY-2018, entry version 47. DE SubName: Full=Hemochromatosis {ECO:0000313|Ensembl:ENSSTOP00000013749}; GN Name=HFE {ECO:0000313|Ensembl:ENSSTOP00000013749}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000013749, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000013749} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000013749} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01091233; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 43179.ENSSTOP00000013749; -. DR Ensembl; ENSSTOT00000015349; ENSSTOP00000013749; ENSSTOG00000015350. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3MPL1; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl. DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:Ensembl. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl. DR GO; GO:0030881; F:beta-2-microglobulin binding; IEA:Ensembl. DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl. DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0071281; P:cellular response to iron ion; IEA:Ensembl. DR GO; GO:0042446; P:hormone biosynthetic process; IEA:Ensembl. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:Ensembl. DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IEA:Ensembl. DR GO; GO:1904283; P:negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:Ensembl. DR GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; IEA:Ensembl. DR GO; GO:1900121; P:negative regulation of receptor binding; IEA:Ensembl. DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; IEA:Ensembl. DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR GO; GO:1904434; P:positive regulation of ferrous iron binding; IEA:Ensembl. DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl. DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl. DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IEA:Ensembl. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; IEA:Ensembl. DR GO; GO:1900390; P:regulation of iron ion import; IEA:Ensembl. DR GO; GO:2000008; P:regulation of protein localization to cell surface; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 49 {ECO:0000256|SAM:SignalP}. FT CHAIN 50 376 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5011977286. FT TRANSMEM 332 354 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 237 324 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 376 AA; 42788 MW; 7BCC5FD5BE210885 CRC64; MARCDFWSHC FPARTEAESQ ARPGDMGPRA RRTLPLLLLL LLLVRTVVPQ GRLPRSHSLR YLFMGASELD LGLPLFEALG YVDDQLFVSY NHESRRAEAR APWVQGRTSS QLWLQLSQSL KGWDHMFTVD FWTIMDNHNH SKESHTLQVM LGCEVQADNS TRGFWRYGYD GQDHLEFCPD TLDWRAAEPE AWPTKLEWEV HQIRAKQNKV YLQRDCPQQL RQLLELGRGI LDQQVPPWVK VTRRVTSAVT TLRCRALNFY PKNISMRWLK DSQPLDAKVE PQDVLPSGDG TYQGWLALAV PPGEEQRHTC QVGHPGLDQP LMATWAPSSP SALVIGVVSG TVVCILVVFT GVLLRTLRKK HASRGVARDY VLADCQ // ID I3MPY1_ICTTR Unreviewed; 349 AA. AC I3MPY1; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000013925}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000013925, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000013925} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000013925} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01099502; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3MPY1; -. DR STRING; 43179.ENSSTOP00000013925; -. DR Ensembl; ENSSTOT00000015559; ENSSTOP00000013925; ENSSTOG00000015560. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3MPY1; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 349 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013198020. FT TRANSMEM 293 314 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 196 282 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 349 AA; 39131 MW; 328D49B33F52666F CRC64; MLLLMLSGAL ALTETWAGSH SMRYFEISVS RPGGEPWHME VGYVDDTQFV RFDSDAPTPK MEPRAPWIEQ EGPGYWERNT RIAKGNAQSD QVGLNTLRGY YNQSAAVSSH TYQTTYGCDV GTDGRLLRGY SQFAYDGADY IALNDDLRSW TAADTAAQIT RRKWEEGGYA EQERCVRSLA RYLELGKETL LRTDPPKTHV THYPRPEGDV TLRCWALGFY PKEITLNWQR DGEDQTQDME LVETRPAGDG NFQKWAAVVV RAGEEQRYTC HVHHEGLPEA LTLRWEPPSQ PNILIMVIVA GVVLFGAFVA RAVISFVSWR KKNTGVKKGP YAPAICNNSA QGSDVSLTA // ID I3MUH9_ICTTR Unreviewed; 387 AA. AC I3MUH9; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 20-JUN-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000015774}; GN Name=LOC101966190 {ECO:0000313|Ensembl:ENSSTOP00000015774}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000015774, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000015774} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000015774} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01099494; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3MUH9; -. DR STRING; 43179.ENSSTOP00000015774; -. DR Ensembl; ENSSTOT00000021218; ENSSTOP00000015774; ENSSTOG00000020294. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3MUH9; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 387 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013220659. FT TRANSMEM 305 328 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 387 AA; 43646 MW; 659395883B6A4CCF CRC64; MGVTAPRTLL LMLSWALALT ETWAGSHSLR YFHTSVSRPG GEPRFISVGY VDDSQFMRFD SDAENPRMEP RAPWIEQEGP EYWERETRTA KDNAQVFRGN LNTALRYYNQ SAGGSHTIQS TSGCDVGTDG RLLRGYRQYA YDGRDYIALN DDLRSWTAAD TAAQITKRKW EAAGEAERLR AYLEGECGQW IARNLKNRKE MLLRTDPPKT HVTHHPRPEG DVTLRCWALG FYPKEITLNW QRDGEDQTQD MELVETRPAG DGNFQKWAAV VVPAGEEQRY TCHVHHEGLP EPLTLRWKPP PQATIPIVGI VAAVVLLGAV VIGAVIYFKK NTGRESVKKG PYAPAACNDS AQGSDVSLTA EKGETLKRER GWGMERLLGY RDFLRDF // ID I3MVA7_ICTTR Unreviewed; 295 AA. AC I3MVA7; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000016052}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000016052, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000016052} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000016052} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01099505; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01099506; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3MVA7; -. DR STRING; 43179.ENSSTOP00000016052; -. DR Ensembl; ENSSTOT00000029446; ENSSTOP00000016052; ENSSTOG00000021130. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3MVA7; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 238 261 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 141 229 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 295 AA; 33436 MW; F3414F1426B502F0 CRC64; MEPRAPWIEQ EGPEYWERNT RNAKRQAQTD RRSLNTLRGY YNQSAGGSHT VQHMYGCDVG TDGRLLRGYV QIAYDGGDYI ALNEDLRSWT AADTAAQITR RKWEAAGVAE QERAYLEVRC VEWLLRYLEN GKESLRRTDP PKMHVTHHPR PKGDVTLRCW ALGFYPKEIT LNWQRDGEDQ TQDMELVETR PAGDRNFQKW AAVVVPAGEE QRYTCHVHHE GLPEPLTLRW EPPPQSTITI MGIVAAVIVL VVTGAVVYFV MGKKKNTGVK KGHYTPAVCN DSAQGSDVSL TAEKV // ID I3MVH6_ICTTR Unreviewed; 370 AA. AC I3MVH6; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 20-JUN-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000016121}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000016121, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000016121} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000016121} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01099490; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01099491; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSSTOT00000025918; ENSSTOP00000016121; ENSSTOG00000027066. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3MVH6; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 370 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012903940. FT TRANSMEM 316 340 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 217 303 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 370 AA; 41869 MW; AF32B522B17C1792 CRC64; MVCTLSTGDF LLSRVSLLLL PTRVRSFCLA TLDTRLPSPG SHSMRYFYTA VSRPDGEPRF ITMGYVDDSH DAKTPRMEPR ASWIEQEGPE YWELETLTAK SDIPSDQVNL KTLRGYYNQS AGSSHFIQRT YGCDVGTDGR LLRGYVQIAY NGVDYLVLNK DLRSWTAAQM TGSKWEADGA AEHHRTYLEG RCVERLTRYP GEREGAAISV FFPSDPPKTH VTHHPNPEGD ITLRCWALGF YPKEITQTWQ RDGEDQTQDM ELVETRPAGN GNFQKWAAVV VPAGEEQRYT CHVHHEELPE SFTLRWEPPS QSTIRFLRIV VGLILLGAVV TGAVVAFVLW RKKNTDRESV KKGPYAPAAC KYEEYGSLRP // ID I3MX11_ICTTR Unreviewed; 319 AA. AC I3MX11; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000016656}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000016656, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000016656} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000016656} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01099502; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3MX11; -. DR Ensembl; ENSSTOT00000019713; ENSSTOP00000016656; ENSSTOG00000015560. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 263 284 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 166 252 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 319 AA; 35623 MW; D784BE208A62762A CRC64; MLSGALALTE TWAGSHSMRY FEISVSRPGG EPWHMEVGYV DDTQFVRFDS DAPTPKMEPR APWIEQEGPG YWERNTRIAK GNAQSDQVGL NTLRGYYNQS AAVSSHTYQT TYGCDVGTDG RLLRGYSQFA YDGADYIALN DDLRSWTAAD TAAQITRRKW EEGDPPKTHV THYPRPEGDV TLRCWALGFY PKEITLNWQR DGEDQTQDME LVETRPAGDG NFQKWAAVVV RAGEEQRYTC HVHHEGLPEA LTLRWEPPSQ PNILIMVIVA GVVLFGAFVA RAVISFVSWR KKNTGVKKGP YAPAICNNSA QGSDVSLTA // ID I3MXQ4_ICTTR Unreviewed; 389 AA. AC I3MXQ4; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000016899}; GN Name=LOC101956844 {ECO:0000313|Ensembl:ENSSTOP00000016899}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000016899, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000016899} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000016899} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01123727; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 43179.ENSSTOP00000016899; -. DR Ensembl; ENSSTOT00000025680; ENSSTOP00000016899; ENSSTOG00000029130. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3MXQ4; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 389 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012203952. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 389 AA; 43717 MW; E636410481A1213D CRC64; MRVMAPRTLL LLLSGALALT ETWAGSHSLR NFYTSVSRPG GEPRFIAVGY VDDTQFVRFD SDAENPSAEP RAPWIEQEGP EYWEQNTQRV KGKAQVFRVN LNTLLGYYNQ SAGGSHTLQK MSGCDVGTDG RLLRGYQQYA YDGGDYIALN HDLRSWTAAD TAAQITKRKW EAAGDSEFRR AYLEGECVEW LRRYLENGKE TLLRTDPPET HVTHHPSPDG DVTLRCWALG FYPKEITLTW QRDEEDQTQD MELVETRPAG DGNFQKWAAV VVPAGEEQRY TCRVHHKGLP EPLTLRWEPP PQATIPVMGI VAAVIVLVVT GAVVGFFLWR KKNTGVKKGP YAPAACNDSA QGSDVSLTAE KGEILEVLER ERGWGMRRLL GYRDSLRDL // ID I3MZ83_ICTTR Unreviewed; 342 AA. AC I3MZ83; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000017429}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000017429, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000017429} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000017429} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01099529; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3MZ83; -. DR Ensembl; ENSSTOT00000023336; ENSSTOP00000017429; ENSSTOG00000027981. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3MZ83; -. DR OrthoDB; EOG0907079Q; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 286 309 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 342 AA; 39705 MW; 66A32DB5EB040641 CRC64; LLFGALALTN TWAGSHSLKF LITAMSRPLR GEPHIIEIGY VDDTPFLRFE FDDASIRRME PQTPWIELEG REYWHRETQY ARRLQQIYRE GLKILLSYYN QSDDVSHTFQ RVYGCDVGPD WRLLRGYWQY AYEGTDYIAL NEDLRSWTVA DTAAQITQRK WEAEGVTETN RAFLEWECLE TLRKHLENGK ETLQRTDLPL THITHHPISD HEVTLRCWAL GFYPAEITLT WQRDGEDQTQ EMELVETRPA GDGKFQKWAA VVVSSGEEQR YTCHVQHEGL PESPQFSITF VVMVAGLVLL GAVAAVMMWR KKNSGRKRES YAQPASRFKG DSPVMFLPCK TY // ID I3N3I8_ICTTR Unreviewed; 362 AA. AC I3N3I8; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000018934}; GN Name=LOC101966768 {ECO:0000313|Ensembl:ENSSTOP00000018934}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000018934, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000018934} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000018934} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01099507; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_013219988.1; XM_013364534.1. DR ProteinModelPortal; I3N3I8; -. DR STRING; 43179.ENSSTOP00000018934; -. DR Ensembl; ENSSTOT00000029391; ENSSTOP00000018934; ENSSTOG00000023539. DR GeneID; 101966768; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3N3I8; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5011522647. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40372 MW; AF8035C1EB9E74E6 CRC64; MLVVAPRTLL LLLSGALALP ETSAGSHSLM YFRTAMSPTG GGEPRFISVG YVDDTQFVRF DSEAATPRME PQVRWIEQEG PEYWERETRI AKGNAQYYRV GLNNLRGYYN QSAGGSHTYQ STYGCEVGTD GRLVQGFSEY AYDGADYLTL NKDLRSWTAA DLAAQITQRK WEESGAAEHR RAYLEGTCVE WLARYLEKGK EMLLRTDPPK SHVTHHPSPE GYVTLRCWAL DFYPKEITLI WQREGDDQTQ DMELVETRPA GDGNFQKWAA VVVPAGEEQR YTCHVHHEGL PEVLTLRWEP PPQPTIPIVG IVAGLVLLGT AVTGAVVAFV MWKKKNTGVK KGPYIPAAWN DSAQGSDVSL NA // ID I3N535_ICTTR Unreviewed; 351 AA. AC I3N535; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 20-JUN-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000019481}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000019481, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000019481} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000019481} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01099509; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 43179.ENSSTOP00000019481; -. DR Ensembl; ENSSTOT00000026512; ENSSTOP00000019481; ENSSTOG00000025614. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3N535; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 351 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012677843. FT TRANSMEM 298 322 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 351 AA; 39376 MW; A164AFBC99B4E08B CRC64; MRVTEPQTLL LLLFGALALT ETSAGSHSMR YFETSVSRPD RGEPRYLEVG YVDDSQFVRF DSDAATPRMG PRYWEEETQR AQSYAQSYQV NLITLLAYYN QSKGGSHTIQ RMYGCDMGTD GLLLRGFSQI AYDGSDYIAL NEDLRSWTAA DMAAQITKRK WEAAGFAESF RAYLEGTCVE WLARYLENGK ETLQRADPPK THVTHHPIPE GDVTLRCWAL GFYPKEITLN WQRDGEDQTQ DMELVETRPS GDGNFQKWAA VVVPAGEEQR YTCHVHHEGL PEPLTLRWEP PSQPTIPIMG IVAGVVLLGA VLTGALVAFV LWKKKNTGRK ILLLFCPDND SAQGSDVSLN A // ID I3N5S7_ICTTR Unreviewed; 358 AA. AC I3N5S7; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 20-JUN-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000019723}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000019723, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000019723} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000019723} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01132842; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3N5S7; -. DR STRING; 43179.ENSSTOP00000019723; -. DR Ensembl; ENSSTOT00000024511; ENSSTOP00000019723; ENSSTOG00000020951. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3N5S7; -. DR OMA; QPRFIAV; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 358 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003677921. FT TRANSMEM 305 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 358 AA; 40191 MW; 5C1971A8ED59A661 CRC64; CRMGVVELLP LLLLSGALVV TETWASSHSL RYMETLESRP GRGESRFISV GYVDDTQFMR FDSDAKNPRQ EPRAPWMGLE GPEYWEQNTR ISENSAQNHR MCLNTLRGYY NQSDSGSHTL QRIYGCEVGT DGRLLRGFLQ YAYDGADYIT LNDDLRSWTA ADAAAQITQQ KWEATGAAER RRAYLEGTCV EWLLRYLENG KDSLQRLDPP KTHVTHHSSS EGDITLRCWA MGFYPKEITL TWQREGEDQT QDMELVETRP AGDGNFQKWA AVVVPAGEEQ RYTCHVHHEG LPEPLTLRWE PPPQATMGIV AVVIVLVVTG AVVAFVMWKK KNTGVKKGPY APAACNDSVQ GSDVSLSA // ID I3N683_ICTTR Unreviewed; 385 AA. AC I3N683; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000019879}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000019879, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000019879} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000019879} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01111610; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3N683; -. DR STRING; 43179.ENSSTOP00000019879; -. DR Ensembl; ENSSTOT00000027325; ENSSTOP00000019879; ENSSTOG00000019861. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3N683; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 346 369 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 249 337 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 385 AA; 43714 MW; C1239ED122308258 CRC64; MTRPHFLLPL SVVILEKPII VSMKFSQLRF RIIGLSLSWE MEPAASRIFL LLLCESQLLT EIWAGSFSLR YFHTAVSRPG GGQPRYLAVG YVDDTQFVRF DSDAADPRME PRAPWIEQEG LEYWEEQTQR AKDIARSFRV NMRTLRGYYN QSDSGSHTLQ WTYGCDVGRD GRFLRGHNQF AYDGTDYISL NEDLRSWTAA NTAAQISKHK SEAAQEAKYQ RAYLEGECVE WLIKHLENGK ETLQRIDPPK THVTHHPSPE GDVTLRCWAL GFYPKEITLT WQRDGEDQTQ DMELVETRPA GDGNFQKWAA VVVPAGEEQR YTCHVHHEGL PEPLTLRWEP PPQATIPIVG IAAAVIVLVT GAVAGFVLWR KKNTGIKKGP NASAF // ID I3N7P8_ICTTR Unreviewed; 385 AA. AC I3N7P8; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000020394}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000020394, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000020394} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000020394} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01099479; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01099480; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3N7P8; -. DR STRING; 43179.ENSSTOP00000020394; -. DR Ensembl; ENSSTOT00000026506; ENSSTOP00000020394; ENSSTOG00000025368. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3N7P8; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 385 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013334178. FT TRANSMEM 312 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 213 301 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 385 AA; 43583 MW; A1D56EE9CFEA7A45 CRC64; MGVTVPRTLL LMLSGALALT ETWAGECGVG REMDSGERHP RRPQPRFSPL WRGSSRPSTR FVRFDSDAEN PREEPRAPWI EQEGPEYWER NTRIYKDNAQ TFRVNLNAAL RYYNQSAGGS HTVQVMSGCD VGTDGRLLRG YHQHAYDSRD YLTLNDDLRS WTAADTAAQI TKRKWEAAGV AELRRAYLEG ECVESLTRYL ENGKETLLST DPPKTHVTHH PRPEGDVTLR CWALGFYPKE ITLNWQRDEE DQTQDMELVE TRPTGDGNFQ KWAAVVVPAG EEQRYTCHVH HEGLPEPLTL RWEPPPQATS PMVGIVAAVV LLGAVVIGAV IYFVNFFVFC FSCSGNDSAQ GSDVSLTAEK GETLKRERGW GMERLLGYRD FLRDF // ID I3N8A8_ICTTR Unreviewed; 242 AA. AC I3N8A8; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000020604}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000020604, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000020604} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000020604} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01011078; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01011079; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3N8A8; -. DR Ensembl; ENSSTOT00000028638; ENSSTOP00000020604; ENSSTOG00000028098. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3N8A8; -. DR OrthoDB; EOG090B089C; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 185 209 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 88 176 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 242 AA; 27072 MW; 2B838C1E7117047D CRC64; MRYFYTSVSR PGGEPRFIVV GYVDDSQFVR FDSDAENPSV EPRAPWIEQE GPEYWERETR NFKGTAQTFR VNLNTALRYY NQSAGDPPKT HVTHHPSPDG DVTLRCWALG FYPKEITLTW QRDGEDQTQD MELVETRPAG DGNFQKWAAV VVPAGEEQRY TCHVHHEGLP EPLTLRWEPP PQATIPVMGI VAAVIVLVVT GAVVGFILWR KKNTGVKKGP YAPAACNDSA QGSDVSLTAE KV // ID I3N8M3_ICTTR Unreviewed; 318 AA. AC I3N8M3; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000020719}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000020719, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000020719} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000020719} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01124429; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3N8M3; -. DR Ensembl; ENSSTOT00000024615; ENSSTOP00000020719; ENSSTOG00000027163. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3N8M3; -. DR OrthoDB; EOG091G13DH; -. DR TreeFam; TF342059; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 318 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012249145. FT DOMAIN 220 284 IGc1. {ECO:0000259|SMART:SM00407}. SQ SEQUENCE 318 AA; 36715 MW; 9059E494E67C7C4A CRC64; MKFRTLFLLL LGPLTLTQTW ARSHSLRYFH TAVFRAGHEE AFYTSVGYVD DTLFLSLDSD ALNPRVEPRA QWMEYETPAF WEAQTKISEG HKQKLHWNLR STLHYFNQSE DSSHTFQWIS GCDLEPNGSL LQGHEEFAYD GADYISLNED LRSWSSWDKA AQITQRKWED SGDAEHYRAY LQEECLEWLC RFLEKGKDKL LHTESPKTHV TRHLSPEGDA LGFYPKEITM TWQRDGEDQI QNMELVETRP AGDGTFQKWA AVVVPAGEEQ RYTCHVHHEG LPEPLTLRWG KEGLRAQSLL AGKAGALLKI LSRIRAES // ID I3N959_ICTTR Unreviewed; 416 AA. AC I3N959; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000020905}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000020905, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000020905} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000020905} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01119897; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3N959; -. DR Ensembl; ENSSTOT00000028750; ENSSTOP00000020905; ENSSTOG00000027282. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3N959; -. DR OrthoDB; EOG091G0ANY; -. DR TreeFam; TF342166; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 353 372 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 253 342 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 416 AA; 46757 MW; 726A62EE6279C2E4 CRC64; MTEFVILLPQ PPESLGLQVG TTRSSCLCAY SEYAGWSGEQ KLWVEHGWCS HFQEEMSFIV VSSPGAHSLH YSLTVRCQGG SVLSRFFAQG HLDDQPFLSY DSERGSVEPC ALWAETVLGP ETWDTETQDL AENGKNLRVT LADINFLKEE KGGEWSHSLQ ESWGCEIRED NRTRGFWNFY YDGEPFLSYH PETRSWTVQP SPAQILAMKV KNSLDADGIQ SKAQWAHVQG TVCGRLRRYL NSWIAFNETT VSPKVNITCD EVLEDTIIMT CWALGFYPKN IFLTWLQDGK PLSQDTQKSG SILSYGNGTY QTWVSTRIPQ GQEQRFSCHV GHSGNHINGT VSCSTALLLR SRWPTILAAV VGAVIILFWL LWCKKRRTTS AAQGPGEKSV CTFLDKHAPC SHPNKKKSYH TGTLKL // ID I3N9V2_ICTTR Unreviewed; 383 AA. AC I3N9V2; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000021149}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000021149, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000021149} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000021149} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01099994; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3N9V2; -. DR Ensembl; ENSSTOT00000021959; ENSSTOP00000021149; ENSSTOG00000028870. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3N9V2; -. DR OrthoDB; EOG091G0ANY; -. DR TreeFam; TF342166; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 383 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012067869. FT DOMAIN 216 305 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 107 130 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 383 AA; 43218 MW; 5121938B1A4911AA CRC64; MPAPLHFPFL CSLLPLSFLS TFLSPLHWKS FFCPFVCVFA ASSGTHSLHY KLTVRSRGGS VQSRFFADCY WDHQFFLHYD SHEKESAKPQ ELWAEKPLGT ESWDTEIQEL IEHSKNLKAT LAEINAQQEK KGGSHSLQET WGCKIEEDNR TRGFWNFHYD GEPFLSYHPE TRSWKVEPSS AQTLPMEVKN SWDADGIQTT LVTCLTNFAL SSLVSPAVNV TCGEALEDTI NMTCWAFGFY PQNISVTWLQ DGEPWSQGTQ QSWGVFPYVN GTYQTWVSIR IPQGQEQRFC CYVGYRGNNS TGLVSCGTAL LLESQWPPLW WYPLLLLGLF SCIPSCKKRR TSAAEGSELV SLKVLDQQQR APSDHTGSTQ LGCQPLLRAP GAS // ID I3NAC6_ICTTR Unreviewed; 362 AA. AC I3NAC6; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000021323}; GN Name=LOC101965888 {ECO:0000313|Ensembl:ENSSTOP00000021323}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000021323, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000021323} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000021323} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01099488; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3NAC6; -. DR STRING; 43179.ENSSTOP00000021323; -. DR Ensembl; ENSSTOT00000027310; ENSSTOP00000021323; ENSSTOG00000023150. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3NAC6; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013220662. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40744 MW; 59843DE70E2E4A1F CRC64; MMGVMAPRML FLMLSGALAR TETWEGSHSM RYFITAVSRP GGESRFITVG YVDDTQFVRF DSDAETPRME PLAPWIEQEG PEYWERETQK AKGHSQIDLM SLNNLRGYYN QSADGSHTLQ RMSGCDLGTD GRLLRGFEQR AYDGKDYLAL NEDLRSWTAA DVAAQITRRK WEAAGDAEHH RAYLEGECVE SLTRYLENGK ETLLRTDPPK MHVTHHPRPE GDITLRCWAL DFYPKEITLT WQRDGEDQTQ DMELVETRPA GDGNFQKWAS VEVPAGEEQR YICHVHHEAL PEPLTLRWEP PSQPTIPMVG IVAGVILLGV AVTGAVVAFV LWKKKNTGVK KGPYAPAKGN DSAQDSYVSL TA // ID I3NBL8_ICTTR Unreviewed; 245 AA. AC I3NBL8; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 20-JUN-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000021765}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000021765, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000021765} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000021765} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01127986; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3NBL8; -. DR Ensembl; ENSSTOT00000025328; ENSSTOP00000021765; ENSSTOG00000028425. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3NBL8; -. DR OrthoDB; EOG091G13DH; -. DR TreeFam; TF342059; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 245 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012226607. FT DOMAIN 18 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 245 AA; 27621 MW; D2F180B049208B04 CRC64; MLLLVLLGAL ALRDTWAGSH SLRYFDTSVS RPGGAPRFIS VGYVDDTQFV RFDSDAENPR MEPRAPWMEK MGPEYWERET QTSKCNLQSH QVSLNTLRGY YNQSAGGPGT GSHTFQRMYG CDVGTDGRLL RGYLQDAYDG ADYIALNEDL CSWTTADAVA EITKRKGEAA GDAESFRAYL EGDCWKYLAG YLEKGKESLQ RTVVPRRRGG EWPHHSAHSP EGRVWAWIPQ FCTREELKAA FSEDK // ID I3ND89_ICTTR Unreviewed; 351 AA. AC I3ND89; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000022336}; GN Name=LOC101967338 {ECO:0000313|Ensembl:ENSSTOP00000022336}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000022336, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000022336} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000022336} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01099511; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3ND89; -. DR STRING; 43179.ENSSTOP00000022336; -. DR Ensembl; ENSSTOT00000024259; ENSSTOP00000022336; ENSSTOG00000019725. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3ND89; -. DR OrthoDB; EOG091G13DH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 351 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012406986. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 351 AA; 39364 MW; DD5D0C3BFFA54AF3 CRC64; MGVVAPRELL LLLLGTLALT DIWAGSHSLR YFDTSVSRPG HGKPRFISVG YVDDTQFVRF DSDAENPREE ARAPWIEQEG SEFWDQITQI STSNAHHHLV CLNNLRGYYN QSEGGSHILQ RIWGCDVGPD RRFLRGYKQY AYDGKDYISL NEDLSSWTSA DAAALNTQRK LEAAGDAEHS RAYLEGTCVE ELLRYLENGK DTLQRLDPPK THLTHHTSPD GDVTLKCWAL GFYPKEITLN WQRDGEDQIQ DLELVETRPA GDGNFQKWAA VVVRAGEEQR YTCHVHHEGL PEPLILRWEP PSQPIMGIVA GLVLLGAVVT GAVVPFVLWK KKNTGRKSND SAQDSDVSLT A // ID I3NE43_ICTTR Unreviewed; 417 AA. AC I3NE43; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 20-JUN-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000022640}; GN Name=LOC101958159 {ECO:0000313|Ensembl:ENSSTOP00000022640}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000022640, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000022640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000022640} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01110844; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005340942.1; XM_005340885.2. DR ProteinModelPortal; I3NE43; -. DR Ensembl; ENSSTOT00000027182; ENSSTOP00000022640; ENSSTOG00000022405. DR GeneID; 101958159; -. DR eggNOG; ENOG410IGE3; Eukaryota. DR eggNOG; ENOG41114P3; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3NE43; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 369 390 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 269 356 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 417 AA; 46758 MW; AAA803C165145E08 CRC64; MHYARTPLPA ECAKLEAKGQ RSLRSAQVGL APSLLLLLLL LLSELVPECA AESPWGLPVI ADGPASLAKV VMAELSSLKF EEKTWPGGTH SLHYHYLTLS EPGPGLPKFL AVGYVDDQPF IRYDSCRGKA EPQAPWMALV DSQYWETETQ KQRAWEKVQQ VEMWTVMGYH NQSGGIHSAQ RMFGCEIQED GRSSSFWQFG FDGQDHLSLD LETLSWVSAE PVAVRTKRWW EMERCYAEYD KAYLESLCLI SLHRYLELGS QSLTRIEPPM VQVTKHTTQD GTMLRCWALG FYPPDISLSW WLGRKELVLE TEHVETRPSG DGTYQTWTSV RVPAGKEAWY TCHVQHPGLK QRLTVAWDSS SIGNGNGNGI LLGGIMVLVF VGLVAVIVIL KKKYLQGGED NLNSQSPERT EAAQTLC // ID I3NE83_ICTTR Unreviewed; 256 AA. AC I3NE83; I3ND52; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000022680}; GN Name=LOC101956127 {ECO:0000313|Ensembl:ENSSTOP00000022680}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000022680, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000022680} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000022680} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01099992; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_013220057.1; XM_013364603.1. DR Ensembl; ENSSTOT00000024957; ENSSTOP00000022680; ENSSTOG00000026935. DR Ensembl; ENSSTOT00000028104; ENSSTOP00000022299; ENSSTOG00000026935. DR GeneID; 101956127; -. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G0ANY; -. DR TreeFam; TF342166; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 182 205 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 73 173 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 256 AA; 28142 MW; E5C2295C1EF41284 CRC64; MIHYDGEPFL SYHPEMRSLR VEPSSAQTLA MEVKNSWDAD GIQSKDIWAQ VQGELCGKLW TYQVFWKGSS LSPGASAQGT LLSPTVNVTC GETSEDTINV TCWACGFYPQ NISVTWLQDG ELLSQDTQDS VDIFPFGNGT YQTWLSTRIP QGQEQRFSCH VVHIGKNTTV SVSCGVGLRK EWPIFLSVAV LLIMTVMILV CVYYYKKNKT PSAAEASEQV SLQVLDGLQR PPSDHAGSTQ LGCQPLLRAP KASQGA // ID I3NEW7_ICTTR Unreviewed; 311 AA. AC I3NEW7; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 23-MAY-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000022914}; GN Name=Azgp1 {ECO:0000313|Ensembl:ENSSTOP00000022914}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000022914, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000022914} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000022914} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01053194; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01053195; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005328487.1; XM_005328430.2. DR ProteinModelPortal; I3NEW7; -. DR Ensembl; ENSSTOT00000026818; ENSSTOP00000022914; ENSSTOG00000028979. DR GeneID; 101968250; -. DR CTD; 563; -. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3NEW7; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 311 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5011448714. FT DOMAIN 207 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 311 AA; 35225 MW; F3D525F92B9F68FC CRC64; MVTMVPVLLS LPLLLGHAVP QETQAGPYSL TFLYTGVSRP SKGLPRFQAT AFLNDQAFFH YDSEGRKAEP LGPWSQVEGM EDWEKESQLQ KAREEIFLVT LKDIMDYHKD SRGSHTFQGM FGCEIQNNRS NGAFWRYAYD GQDFIEFNKE IPAWVPLDPA ALNTKKKWEA EKVYVQRAKA YLEQECPEIL QRYLNHSRTH LDQQDPPSVS VTSHVAPGRN RTLKCLAYDF YPQRIGLRWT RAGKVQETKA GGEILPSGNG TYQSWVVVGV PPEDRAPYLC LVEHSGLAQP LTVPWNGRQK ARAEGKLGTP Q // ID I3NF59_ICTTR Unreviewed; 392 AA. AC I3NF59; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000023006}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000023006, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000023006} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000023006} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01124243; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3NF59; -. DR Ensembl; ENSSTOT00000024049; ENSSTOP00000023006; ENSSTOG00000021102. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; I3NF59; -. DR OrthoDB; EOG091G0ANY; -. DR TreeFam; TF342166; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 392 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013243466. FT TRANSMEM 318 339 Helical. {ECO:0000256|SAM:Phobius}. FT COILED 89 109 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 392 AA; 43374 MW; 65826B38975B9DFB CRC64; IALGNFLLSL CVCLLPPQVL RTAEPFLHYN LTVRSQGGSV QSRSFANGYW DHQLFLHFDS DKKENVKPQG PWSEKPLGSE SWDTEIQELA EHSKNLKATL ADINAWQEQK GGSHFLQETW GCKIHKDNRT RAFWNFYYDG KPFLSYHPET RSWTVEPSSA QNLAMEVKNS WDADGMQSKD YWAHVQGELC GRLRTYLVFW KGSSYSPGAS AQRTLLSPAV NVTCAEALED TINVTCWAFG FYPKNISVTW LQDGEPLSQD AQQTGGIFSY ENGTYQTWVS TRIPQGQEQG FSCHVGHSGN NSTGLVSCGT ALLLPNQWTA FLGVAAAAVA MIMIIVCVCS CKKRKTKCTS EGSKPLSLYN LDQQQRAPSD YTGSTQLGCQ PLLRAPGASG GA // ID I3NGU5_ICTTR Unreviewed; 347 AA. AC I3NGU5; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 20-JUN-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000023592}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000023592, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000023592} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000023592} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01099980; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSSTOT00000028803; ENSSTOP00000023592; ENSSTOG00000029000. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3NGU5; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 347 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013084900. FT TRANSMEM 302 326 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 347 AA; 39843 MW; 2CF605C9793352EB CRC64; MKFRTLFLLL LGPLTLIQTW ARSHSLRYFH TSVSRPGHEE YFYTSVGYVD DTLFLHFDSD APNPRVEPRV QWMELEAPEF WEAQTKIAKA HAQKLSWNLR STLRYYNQSE DGSHTFQWIS GCDLGPDGSL LRGYEEFAYD GADYISLNED LRSWTAWDKA AQITQRKWED SGDAEHYRAY LQEECLEWLR RFLEKGKDKL LHTESPKTHV TYHFSPEGDV TLRCWALGFY PKEITLTWQK DGEDQIQNME LVETRPAGDG TFQKWAAVVV PAEEEQRYTC HVHHEGLPEP RTVRWESPAL SIIPVMGIVA GLVLFVVVVT GAAVAVMKSW QNAGNVSARP SNTSLAP // ID I3NH74_ICTTR Unreviewed; 335 AA. AC I3NH74; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000023721}; GN Name=LOC101967717 {ECO:0000313|Ensembl:ENSSTOP00000023721}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000023721, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000023721} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000023721} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01099980; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005339080.1; XM_005339023.2. DR RefSeq; XP_013220099.1; XM_013364645.1. DR ProteinModelPortal; I3NH74; -. DR Ensembl; ENSSTOT00000021010; ENSSTOP00000023721; ENSSTOG00000024982. DR GeneID; 101967717; -. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3NH74; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 335 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5011551062. FT TRANSMEM 299 322 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 335 AA; 38447 MW; AA4F84C1A2BAA8CC CRC64; MARRTLFLVL LGVLALTETW AGSHSLRYFD IAMTWPGRRE YQYMTVGYVD DTQFVLFDSY AANPRMEPRA QWMDQVGPEY WEDQTRICKN SAQIDLGNLR NLLRYHNQSE GGSHTLQWTL GCEVGPDGRL LRGYRQAAYD GVDYLALNED LHSWTAVDAA ARITLHKWDT EFYRAYLEGP CVEWLHRYLE KGKEVLQRSD PPKTRVTYHP SPEGDITLRC WALGFYPKEI TLIWQRDGED QTQEMELVET RPAGDGTFQK WAAVVVPAGE EQRYTCHMHH EGLPEPLTLR WEPPSQSTIP VMGIVVGLVL LIAVVTGAVV SVMMQRRNAD RRGVI // ID I3NHB7_ICTTR Unreviewed; 352 AA. AC I3NHB7; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000023764}; GN Name=LOC101967997 {ECO:0000313|Ensembl:ENSSTOP00000023764}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000023764, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000023764} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000023764} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTP01099980; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005339081.1; XM_005339024.2. DR ProteinModelPortal; I3NHB7; -. DR Ensembl; ENSSTOT00000024061; ENSSTOP00000023764; ENSSTOG00000026054. DR GeneID; 101967997; -. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; I3NHB7; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 352 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5011545210. FT TRANSMEM 302 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 352 AA; 39910 MW; D81D544A82F9EC4D CRC64; MAPRTLFLLL SGVLTLSETW AGSHSLRYFD TAVSRPGLQE PRFISVGYVD DTQFLRFDSD SGTTPRAEPR VQWMKQLGPD YWDRETSKAK DAAQIYWGSL NNLRVYYNQS EGRSHTLQIS SGCDMDAEGR LLRGYRQSAY DGTDYIALNE DLSSWTAANA VAQATRRKWE AAGASEPWRA YLEGPCVEWL GKYLENGKEM LLRTDPPKTY MTHHPRPEGD VTLRCWAMGF YPKEITLIWQ RDGEDHTQDM ELVETRPAGD GTFQKWAAVV VPAGEEQRYT CHVHHEGLPE PCTLRWEPRP QLIIFVMGII AGLVVLGAVV AIAIWLKMNH RREEECSDIA QGSNVSLMAY KA // ID K7DYW0_MONDO Unreviewed; 202 AA. AC K7DYW0; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 12-SEP-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000038711}; GN Name=LOC103098426 {ECO:0000313|Ensembl:ENSMODP00000038711}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000038711, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000038711, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000038711} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR RefSeq; XP_007472683.1; XM_007472621.2. DR Ensembl; ENSMODT00000041819; ENSMODP00000038711; ENSMODG00000027380. DR GeneID; 103098426; -. DR KEGG; mdo:103098426; -. DR Proteomes; UP000002280; Chromosome 1. DR Bgee; ENSMODG00000027380; Expressed in 1 organ(s), highest expression level in testis. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 202 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003903795. FT DOMAIN 46 198 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 202 AA; 23813 MW; EB71E5435CD0C115 CRC64; MLTYITRFGM MRPLFTANFL FLLSGTIMSQ RPRIRCDVLH LKDFGFSNPQ DGHYSFKNEV YLNGQTVYTY DSKSKRAVPQ PEWQNVENWN EVSQLQKERE ELIMKDLEEI RNLNTDNTDI YTTSQNVACQ LCSNDAFRMS GYSLVEGKEF SKKSKRVFTL ATQDPAAEMM KHQSKQDPMF HGYQEKKCIE ILQKYRNYRD AH // ID K7DYZ7_MONDO Unreviewed; 202 AA. AC K7DYZ7; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 12-SEP-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000038748}; GN Name=LOC103098191 {ECO:0000313|Ensembl:ENSMODP00000038748}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000038748, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000038748, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000038748} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR RefSeq; XP_007472682.1; XM_007472620.2. DR ProteinModelPortal; K7DYZ7; -. DR Ensembl; ENSMODT00000041856; ENSMODP00000038748; ENSMODG00000029679. DR GeneID; 103098191; -. DR KEGG; mdo:103098191; -. DR Proteomes; UP000002280; Chromosome 1. DR Bgee; ENSMODG00000029679; Expressed in 2 organ(s), highest expression level in testis. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 202 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003900193. FT DOMAIN 39 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 202 AA; 23702 MW; 4F62AC3612E3DFA4 CRC64; MLTYNSRFGM MKPLFTAIFL FLLSGTIMSQ HPRTRCDVLQ YKNMGYSNPQ TGRYSFKNEV NLNERTVYVY DSSSKRAVPQ PGWENVENWN KVSQLQKERE ELIMKDLQEI RNLNTDTTGT YTVTHTFDCQ LCPNDAFAIS GYNLFEGNEF SKNFKRIFTL ATQDPAAEMM KQQSQRYPML HGYQETQCVE TLQKYLNYRD AH // ID K7E520_MONDO Unreviewed; 201 AA. AC K7E520; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 12-SEP-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000040872}; GN Name=LOC103098877 {ECO:0000313|Ensembl:ENSMODP00000040872}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000040872, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000040872, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000040872} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR RefSeq; XP_007472685.1; XM_007472623.1. DR ProteinModelPortal; K7E520; -. DR Ensembl; ENSMODT00000043980; ENSMODP00000040872; ENSMODG00000028158. DR GeneID; 103098877; -. DR KEGG; mdo:103098877; -. DR GeneTree; ENSGT00740000115973; -. DR Proteomes; UP000002280; Chromosome 1. DR Bgee; ENSMODG00000028158; Expressed in 5 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 201 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003900379. FT DOMAIN 28 187 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 201 AA; 23693 MW; 2BE35798F2382366 CRC64; MMRLLFTAIF LILISGTLMF QHTAFNCYFL TYKDTIFSKP QTGNYSFKNA AYINGHTIYI YDNSHKRAVP QPGWQYLENW DEVSQLQKKR EDLIMKNLQE IMNSNEGTFT YTEYITCCIC PYKYLKVIRI FYINGEKFIK TNKNMLAQAS HNPAAEMIKQ KLKHDKGALN QLNAYLEKQC PAKLQRYKTS YYARLPRVRG N // ID K7E7S6_ORNAN Unreviewed; 146 AA. AC K7E7S6; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 12-SEP-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000029583}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000029583, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [2] {ECO:0000313|Ensembl:ENSOANP00000029583} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000029583}; RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; K7E7S6; -. DR Ensembl; ENSOANT00000038827; ENSOANP00000029583; ENSOANG00000029890. DR GeneTree; ENSGT00870000137161; -. DR InParanoid; K7E7S6; -. DR OrthoDB; EOG091G08B2; -. DR Proteomes; UP000002279; Unplaced. DR Bgee; ENSOANG00000029890; Expressed in 5 organ(s), highest expression level in liver. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}. FT DOMAIN 4 111 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 146 AA; 16716 MW; 8D11DBC5B3B9744F CRC64; MSIPSAWWIL ETDVGDHLKD LKRIATGLAR DSQDSLRDLP RYYNQTEGGS HSIQTMFGCE VEDNGTVRNG YYQVGYDGQD YIALERNHKN MTWVAADTVA QITKNMWEAN PFFLGCLGFF MASVKYLRRA RHCTKRWGVR LDMGPA // ID K7FAM8_PELSI Unreviewed; 262 AA. AC K7FAM8; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPSIP00000005088}; OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae; OC Pelodiscus. OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000005088, ECO:0000313|Proteomes:UP000007267}; RN [1] {ECO:0000313|Ensembl:ENSPSIP00000005088} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17381049; DOI=10.1080/10425170600760091; RA Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.; RT "The complete mitochondrial genome of the Korean soft-shelled turtle RT Pelodiscus sinensis (Testudines, Trionychidae)."; RL DNA Seq. 17:471-483(2006). RN [2] {ECO:0000313|Proteomes:UP000007267} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267}; RG Soft-shell Turtle Genome Consortium; RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPSIP00000005088} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGCU01119250; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01119251; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01119252; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01119253; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01119254; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01119255; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K7FAM8; -. DR Ensembl; ENSPSIT00000005117; ENSPSIP00000005088; ENSPSIG00000004748. DR eggNOG; ENOG410IZF6; Eukaryota. DR eggNOG; ENOG41119ST; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; NETEKTH; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Proteomes; UP000007267; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007267}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000007267}. FT DOMAIN 175 262 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 262 AA; 29470 MW; 5D5BBCEEAE3AEDF0 CRC64; MVTGVTYENG TYQYAMDIRL DGVRIGRYSS DTREVTPMLP WLGRALGSKY LQERTKEFQA HEQRLKEMIG WCMQQDSQRG GIHTGQVHIH CSLSDQAPVA PRFQFAYDGQ DLISFDNQTG TWVADVPVAS QLKQIWEKES TWTQYVQFFM RDDCLQTLRS LVQLRQWVLL SPVLPEVSVS LRDAPHGPVT LSCRASGFHP RPIHLSWVRD GGDVLAETSS SGILPLADGT YHTQSSLEIG PRPDGPRYAC RVEHSSLPAP AL // ID K7FB74_PELSI Unreviewed; 346 AA. AC K7FB74; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPSIP00000005284}; OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae; OC Pelodiscus. OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000005284, ECO:0000313|Proteomes:UP000007267}; RN [1] {ECO:0000313|Ensembl:ENSPSIP00000005284} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17381049; DOI=10.1080/10425170600760091; RA Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.; RT "The complete mitochondrial genome of the Korean soft-shelled turtle RT Pelodiscus sinensis (Testudines, Trionychidae)."; RL DNA Seq. 17:471-483(2006). RN [2] {ECO:0000313|Proteomes:UP000007267} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267}; RG Soft-shell Turtle Genome Consortium; RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPSIP00000005284} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGCU01119256; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K7FB74; -. DR Ensembl; ENSPSIT00000005314; ENSPSIP00000005284; ENSPSIG00000004896. DR eggNOG; ENOG410IZF6; Eukaryota. DR eggNOG; ENOG41119ST; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; ECKLEAN; -. DR OrthoDB; EOG091G0CEJ; -. DR TreeFam; TF352056; -. DR Proteomes; UP000007267; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007267}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007267}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 302 324 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 283 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 346 AA; 37751 MW; E2505762F52F9765 CRC64; PGWCGAQGTE QLLHSISAVA TGHRSLAVLV TGVHEEGIND FTMSTLVDGV RVAHYSSRTR EVRPTQGWAA QALDAGFLQK KTQEFWGHEE GSKAQTQRWM QLYNQTGGVH TEQLHARCAL GDQTPNYLRF QYAYDGQDFI SFDLQTGTWV AAVQPAVFQK QYWETHKIWT RYVQWFLQHE CLEILRSLVQ QGQGVLERQV PPEVSVSRRA APHGPVTLSC RASGFHPRPI HLSWVRDGGD VLAETSSSGI LPLADGTYHT QSSLEIGPRP DGPRYACRVE HSSLPAPALV WAPEKGPLPP GVLAAIVLAV LGLAGAAGAG VWLWRRKSAG ESRSLQGSAI GLSPAG // ID K7FCT7_PELSI Unreviewed; 174 AA. AC K7FCT7; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 28-MAR-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPSIP00000005847}; OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae; OC Pelodiscus. OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000005847, ECO:0000313|Proteomes:UP000007267}; RN [1] {ECO:0000313|Ensembl:ENSPSIP00000005847} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17381049; DOI=10.1080/10425170600760091; RA Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.; RT "The complete mitochondrial genome of the Korean soft-shelled turtle RT Pelodiscus sinensis (Testudines, Trionychidae)."; RL DNA Seq. 17:471-483(2006). RN [2] {ECO:0000313|Proteomes:UP000007267} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267}; RG Soft-shell Turtle Genome Consortium; RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPSIP00000005847} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGCU01026990; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K7FCT7; -. DR Ensembl; ENSPSIT00000005882; ENSPSIP00000005847; ENSPSIG00000005439. DR eggNOG; ENOG410IUPG; Eukaryota. DR eggNOG; ENOG4110PXI; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000007267; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007267}; KW Reference proteome {ECO:0000313|Proteomes:UP000007267}. FT DOMAIN 103 174 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 174 AA; 20090 MW; A2CF9DF683FEBEE8 CRC64; MERYNQSGGQ HTFQYAYGCW LPADGSSWGF RRYGYDGQDF LSYDTHTHNW VAPSNEAQLT KGKMESDRHL SQQQRDYLEH KCVEWLRTYL GHGKETLQRR ERPAVRVTSK GTPGGPSTLT CRAHGFYPRE IAVRWLRKGV SREQETWRGG GLXXXXXXXX XXXXXXXXXX XXXX // ID K7FJR6_PELSI Unreviewed; 242 AA. AC K7FJR6; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPSIP00000008276}; OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae; OC Pelodiscus. OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000008276, ECO:0000313|Proteomes:UP000007267}; RN [1] {ECO:0000313|Ensembl:ENSPSIP00000008276} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17381049; DOI=10.1080/10425170600760091; RA Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.; RT "The complete mitochondrial genome of the Korean soft-shelled turtle RT Pelodiscus sinensis (Testudines, Trionychidae)."; RL DNA Seq. 17:471-483(2006). RN [2] {ECO:0000313|Proteomes:UP000007267} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267}; RG Soft-shell Turtle Genome Consortium; RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPSIP00000008276} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGCU01110608; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K7FJR6; -. DR STRING; 13735.ENSPSIP00000008276; -. DR Ensembl; ENSPSIT00000008319; ENSPSIP00000008276; ENSPSIG00000007578. DR GeneTree; ENSGT00900000140849; -. DR OrthoDB; EOG091G0NF1; -. DR Proteomes; UP000007267; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007267}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007267}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 190 211 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 80 181 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 242 AA; 26756 MW; 86AAEDD7A4BB9F02 CRC64; MQVLKTCELD DATGAIRAVT RYALNGEDVL RYQSDQNRWF SVHPAAWRVA ERWNRAGEMV GVMKLFMPQQ CRFWIENSAP FTAQKTAQPT ARVVLVPGTQ AQPRRLVCHV TGFYPRDIEV TWERRGQVAQ GEQLSSGIRP NGDPTFQIQV SIELGQKRAG PAEHVCVVRH SSLGNTPLRV TWDSQAMGQA LLPLIVAGCI LSLLGLGALG WHLRRSQGDK KGPYSPAQTQ PWTLGSAAAM AK // ID K7FMC8_PELSI Unreviewed; 295 AA. AC K7FMC8; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPSIP00000009188}; OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae; OC Pelodiscus. OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000009188, ECO:0000313|Proteomes:UP000007267}; RN [1] {ECO:0000313|Ensembl:ENSPSIP00000009188} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17381049; DOI=10.1080/10425170600760091; RA Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.; RT "The complete mitochondrial genome of the Korean soft-shelled turtle RT Pelodiscus sinensis (Testudines, Trionychidae)."; RL DNA Seq. 17:471-483(2006). RN [2] {ECO:0000313|Proteomes:UP000007267} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267}; RG Soft-shell Turtle Genome Consortium; RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPSIP00000009188} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGCU01132080; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K7FMC8; -. DR Ensembl; ENSPSIT00000009234; ENSPSIP00000009188; ENSPSIG00000008354. DR GeneTree; ENSGT00900000140849; -. DR OMA; AMKWAND; -. DR OrthoDB; EOG091G0NF1; -. DR Proteomes; UP000007267; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007267}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007267}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 274 292 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 168 260 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 295 AA; 32724 MW; C83749C3B3864CDB CRC64; GLPKSMSVLR VNDLVLAAYD SGIRRLEPRN GYSPGQQDSQ QFWSAGSSKC QGWDSQGDAT YQVLVQEVNA SAPQAEPYYM QILKTCELDD ATGTVQIATR CSLNGEDVLH YRGDQNRWFS VHPAAWRVAE RWNQAAEVFG AMNHLTPQQC QSWIQSSASF IAQQTAQPTG HMALVPRTEA RPRRLICHVT GFYPRPIKVT WEQGEQDALW EQLSSGILPN GDHTFQIQVS IELGQEGAGP TEHVCVVRHS SLANTTLRVT WDSQPTVQTV TMEIVVGCLL TALGVGALGW YLRKK // ID K7FYF3_PELSI Unreviewed; 342 AA. AC K7FYF3; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 28-MAR-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPSIP00000013063}; OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae; OC Pelodiscus. OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000013063, ECO:0000313|Proteomes:UP000007267}; RN [1] {ECO:0000313|Ensembl:ENSPSIP00000013063} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17381049; DOI=10.1080/10425170600760091; RA Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.; RT "The complete mitochondrial genome of the Korean soft-shelled turtle RT Pelodiscus sinensis (Testudines, Trionychidae)."; RL DNA Seq. 17:471-483(2006). RN [2] {ECO:0000313|Proteomes:UP000007267} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267}; RG Soft-shell Turtle Genome Consortium; RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPSIP00000013063} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGCU01110600; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K7FYF3; -. DR Ensembl; ENSPSIT00000013126; ENSPSIP00000013063; ENSPSIG00000011727. DR GeneTree; ENSGT00900000140849; -. DR OMA; NASHFND; -. DR OrthoDB; EOG091G0NF1; -. DR Proteomes; UP000007267; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007267}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007267}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 342 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003905918. FT TRANSMEM 305 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 181 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 342 AA; 38543 MW; C0603F6B15928C37 CRC64; MAPSAKPVLV SFWILNFCCV TLAGLHRVSY LQLVTPQAAS GLPKRLSMLK VDDLLLFIYD SDTRKPVPRN GYNQDRQDIW KLRSTRCLSW DSWVETTYQA LVQDVNTSAP RAEPYYMQIL QSCEWDDATS DIRAATRYAL NGEDMLQHHS DQNRWFPVHP AAWPLAERWN RAREPFGELT PQGCMFLIED SGLLITEKTA QPTAHVTLGP GTQAQPRRLV CHVTGFYPRD IEVTWERRGQ VAQGEQLSSG IRPNGDHTFQ IQVSIELGQE GAGPTEHVCV VRHSNLGDTP LRVTWDSQSP GLPGVLWIMI GCVLAALSIG ALGLFLWKRP GAWKRLYRPA RT // ID K7G580_PELSI Unreviewed; 264 AA. AC K7G580; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 28-MAR-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPSIP00000015441}; OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae; OC Pelodiscus. OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000015441, ECO:0000313|Proteomes:UP000007267}; RN [1] {ECO:0000313|Ensembl:ENSPSIP00000015441} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17381049; DOI=10.1080/10425170600760091; RA Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.; RT "The complete mitochondrial genome of the Korean soft-shelled turtle RT Pelodiscus sinensis (Testudines, Trionychidae)."; RL DNA Seq. 17:471-483(2006). RN [2] {ECO:0000313|Proteomes:UP000007267} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267}; RG Soft-shell Turtle Genome Consortium; RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPSIP00000015441} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGCU01110602; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K7G580; -. DR Ensembl; ENSPSIT00000015513; ENSPSIP00000015441; ENSPSIG00000013783. DR GeneTree; ENSGT00900000140849; -. DR OMA; IENCCTL; -. DR OrthoDB; EOG091G0NF1; -. DR Proteomes; UP000007267; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007267}; KW Reference proteome {ECO:0000313|Proteomes:UP000007267}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 264 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003902547. FT DOMAIN 200 264 IGc1. {ECO:0000259|SMART:SM00407}. SQ SEQUENCE 264 AA; 30404 MW; BF0EC4A98CB3C27B CRC64; LYLLESLCVC LSVWLHRLSF LQLVTSQAAP GLPRRLSVER VNDLVLSVYD SETRQLLPRN GYKQDRQDFW SRCQEWDNWV QTTYQVLTQE VNTSTPQSEF VRTVHILKNC ELDDATGAVQ IVTRYSLNGE DVLRYQSDQN HWFSVHPVAR SLAEHWNRTR LTPQRCKFLI EENPVIRNPL SPTAQPKVRV IPVPAALDQP HRLICHVTDF YPRNIEVTLE RGEQLSSGIR PNGDSTFQIQ VSIKLGQERA GPTEHVCVVR HSSL // ID K7G5M3_PELSI Unreviewed; 280 AA. AC K7G5M3; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPSIP00000015584}; OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae; OC Pelodiscus. OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000015584, ECO:0000313|Proteomes:UP000007267}; RN [1] {ECO:0000313|Ensembl:ENSPSIP00000015584} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17381049; DOI=10.1080/10425170600760091; RA Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.; RT "The complete mitochondrial genome of the Korean soft-shelled turtle RT Pelodiscus sinensis (Testudines, Trionychidae)."; RL DNA Seq. 17:471-483(2006). RN [2] {ECO:0000313|Proteomes:UP000007267} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267}; RG Soft-shell Turtle Genome Consortium; RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPSIP00000015584} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGCU01000124; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01000125; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01000126; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01000127; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPSIT00000015658; ENSPSIP00000015584; ENSPSIG00000013787. DR eggNOG; ENOG410IZF6; Eukaryota. DR eggNOG; ENOG41119ST; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; QYLTHEC; -. DR OrthoDB; EOG091G0CEJ; -. DR TreeFam; TF352056; -. DR Proteomes; UP000007267; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007267}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007267}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 225 247 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 125 206 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 280 AA; 30012 MW; 46CFD6B35B4F504E CRC64; XQAVGAEYLR EKTQQFWVHD VRSKFDIQGW MHLHNQTGGF HTEQVHVGCA LSDQTPVDPH YQYAYDGQDF ISFDNQTGTP AEAALGHGAP GLHADRLQYL THECVWTLRS LVQQGRAVLE RQVPPEVSVS RRDAPHGPVT LSCRASGFHP RPIHLSWVRD GGDVLAETSS SGILPLADGT YHTQSSLEIG PRPDGPRYAC RVEHSSLPAP ALVWAPEKGP LPPGVLAAIV LAALGLAGAA GAGVWLWRRK SAGRRKPGYT PAATKTGDDS ASSSASGTGS // ID K7GBB7_PELSI Unreviewed; 240 AA. AC K7GBB7; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 12-SEP-2018, entry version 39. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSPSIP00000017578}; GN Name=MR1 {ECO:0000313|Ensembl:ENSPSIP00000017578}; OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae; OC Pelodiscus. OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000017578, ECO:0000313|Proteomes:UP000007267}; RN [1] {ECO:0000313|Ensembl:ENSPSIP00000017578} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17381049; DOI=10.1080/10425170600760091; RA Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.; RT "The complete mitochondrial genome of the Korean soft-shelled turtle RT Pelodiscus sinensis (Testudines, Trionychidae)."; RL DNA Seq. 17:471-483(2006). RN [2] {ECO:0000313|Proteomes:UP000007267} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267}; RG Soft-shell Turtle Genome Consortium; RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPSIP00000017578} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGCU01115751; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01115752; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01115753; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K7GBB7; -. DR STRING; 13735.ENSPSIP00000017578; -. DR Ensembl; ENSPSIT00000017657; ENSPSIP00000017578; ENSPSIG00000015586. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; VEHESLL; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000007267; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007267}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007267}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 191 213 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 95 181 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 240 AA; 27048 MW; E953F0A39B9916D7 CRC64; GFHIIQTMYG CDLREDNTTR GFYQDSYDGR DFLTFDKETM TWVAADIGAQ ITKRRFDADV SGKRRWKVYM EEECIQWLKS FLEYGKETLQ RKVRPTVRVR GRSAHDGLRT LSCTVSGFYP RHITATWLRN GESREQDTYS AGPLPNGDGT YRTWVTMEID PQTNAQYACR VEHESLLEPL SVPWEPDNHR IPAVAGGVTA ALLVAMGIGA VVWKKKCSGK EPGIGMGASL HPLTLQTPPS // ID K7GKG4_PIG Unreviewed; 329 AA. AC K7GKG4; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 12-SEP-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000028339}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000028339, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000028339, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000028339}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000028339} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; K7GKG4; -. DR PRIDE; K7GKG4; -. DR Ensembl; ENSSSCT00000035823; ENSSSCP00000028339; ENSSSCG00000024161. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000008227; Chromosome 7. DR Bgee; ENSSSCG00000024161; Expressed in 5 organ(s), highest expression level in lung. DR ExpressionAtlas; K7GKG4; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 281 303 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 267 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 329 AA; 37107 MW; 63E5649C56EEC761 CRC64; ISPFTFLLLD VYTAVSRPGR RETRSIAVGY VDDTQLMRFD SDAPNPRVEL RPSWMEQQGP EYWDLNTRGV KDTAQTPAVN LNTLRRYFNQ SEAGSHTLQW TYGCDAEPDG RLLRRYEQFA YDGEDFIALN EDLRSWTAAD TAAQITKRKW EASGEAERDR NYLPGTCVEW LSRHLEMGKD TLQRRDPPKT HVTRHPSSDL GVTLRCWEIS LTWQREGQDQ SQDMELVETR PSGDGTFQKW AALVVPPGEE QSYTCHVQHE GLQEPLTLRW DPPQPPCPVP IIGIIVGLVL VAEVVVAGIV IWWKKRSGRE GSGDLSLLVS VGVSSPGGS // ID K7GLN3_PIG Unreviewed; 277 AA. AC K7GLN3; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 12-SEP-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000028765}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000028765, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000028765, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000028765}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000028765} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K7GLN3; -. DR PRIDE; K7GLN3; -. DR Ensembl; ENSSSCT00000035848; ENSSSCP00000028765; ENSSSCG00000001341. DR eggNOG; ENOG410J90V; Eukaryota. DR eggNOG; ENOG41117CA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000008227; Chromosome 7. DR Bgee; ENSSSCG00000001341; Expressed in 5 organ(s), highest expression level in lung. DR ExpressionAtlas; K7GLN3; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|PeptideAtlas:K7GLN3}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 277 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003903264. FT TRANSMEM 220 243 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 122 208 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 277 AA; 31439 MW; E002EAE203E1D81C CRC64; MWWAPVLLHS FLSSLQETRA RTHSLQYFYL AMSEAAPGVP AFTAFGVIDD QPFIRYDNEE MKAKSCVQWL REEPSYFNDE TKIFTSRMKI FRLNLRNVQR YYNQTMENGL NKALEHKQTD PPKTHVTRHP SSDLGVTLRC WALGFYPKEI SLNWQREGQD QSQDMELVET RPSGDGTFQK WAALVVPPGE EQSYTCHVQH EGLQEPLTLR WEPPQPPVPI VGIFVGLVLV LVAGAMVAGV VIWRKKRSAE KGGSYTQAAG RDSAQSSGVS LIKDPRV // ID K7GMI5_PIG Unreviewed; 241 AA. AC K7GMI5; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 12-SEP-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000029078}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000029078, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000029078, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000029078}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000029078} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K7GMI5; -. DR STRING; 9823.ENSSSCP00000029078; -. DR PaxDb; K7GMI5; -. DR PRIDE; K7GMI5; -. DR Ensembl; ENSSSCT00000035331; ENSSSCP00000029078; ENSSSCG00000001231. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; K7GMI5; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Proteomes; UP000008227; Chromosome 7. DR Bgee; ENSSSCG00000024161; Expressed in 5 organ(s), highest expression level in lung. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 184 207 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 86 172 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 241 AA; 26701 MW; D4E3DF5DFA094723 CRC64; GCDVGPDGLL LLWYRQDAYG GPDYVALNED LRSWTAADTA AQIAKRKWEA ANVAEQERSY LQGRCVEWLR RYVEMAKDTL QHADPPKTHV TRHPSSDLGV TLRCWALGFY PKEISLTWQR EGQDQSQDLE LVETRPSGDG TFQKWAALVV PPGEEQSYTC HVQHEGLQEP LTLRWDPAQP PVPMVGITVG LVLVLVAGAM VAGVVIWRKK CSGEKGGSYT RAAGHDSAQG SDVFLPMDPR C // ID K7GNK3_PIG Unreviewed; 356 AA. AC K7GNK3; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 12-SEP-2018, entry version 47. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000029457}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000029457, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000029457, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000029457}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000029457} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; K7GNK3; -. DR PRIDE; K7GNK3; -. DR Ensembl; ENSSSCT00000036412; ENSSSCP00000029457; ENSSSCG00000024161. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000008227; Chromosome 7. DR Bgee; ENSSSCG00000001231; Expressed in 6 organ(s), highest expression level in lung. DR ExpressionAtlas; K7GNK3; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 356 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013062326. FT TRANSMEM 308 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 232 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 356 AA; 39956 MW; B16644E815730CE7 CRC64; IRVRGSRALL LLLWGGEGRV SPSSPPPGYH SLRDVYTAVS RPGRRETRSI AVGYVDDTQL MRFDSDAPNP RVELRPSWME QQGPEYWDLN TRGVKDTAQT PAVNLNTLRR YFNQSEAGSH TLQWTYGCDA EPDGRLLRRY EQFAYDGEDF IALNEDLRSW TAADTAAQIT KRKWEASGEA ERDRNYLPGT CVEWLSRHLE MGKDTLQRRD PPKTHVTRHP SSDLGVTLRC WEISLTWQRE GQDQSQDMEL VETRPSGDGT FQKWAALVVP PGEEQSYTCH VQHEGLQEPL TLRWGKEDPP QPPCPVPIIG IIVGLVLVAE VVVAGIVIWW KKRSGREGSG DLSLLVSVGV SSPGGS // ID K7GSB8_PIG Unreviewed; 309 AA. AC K7GSB8; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 12-SEP-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000030799}; GN Name=LOC100153163 {ECO:0000313|Ensembl:ENSSSCP00000030799}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000030799, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000030799, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000030799}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000030799} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9823.ENSSSCP00000030799; -. DR PaxDb; K7GSB8; -. DR PRIDE; K7GSB8; -. DR Ensembl; ENSSSCT00000035608; ENSSSCP00000030799; ENSSSCG00000001394. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; K7GSB8; -. DR OrthoDB; EOG091G0ANY; -. DR TreeFam; TF342166; -. DR Reactome; R-SSC-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000008227; Chromosome 7. DR Bgee; ENSSSCG00000001394; Expressed in 5 organ(s), highest expression level in lung. DR ExpressionAtlas; K7GSB8; baseline and differential. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}. SQ SEQUENCE 309 AA; 34374 MW; 04FD08B5993E4CFA CRC64; MDKVWFAGLC RYLSFLASVV FVLPGTVVAQ HNLWYNFTVM AQDGSVQPTF FAEGRLDGQA FLRRERGTVE PQGLWAKNLS TETWRKETKD LKEKVEDLRK CLGEILGLQK EKGGLHSLQE IVSCEMGEDS HPRGVRRLYY DGELLLSCGL ETHGCTVPQA SAQTLALEME KTCDMDELSR HYWAHVRGEL CAKLQGYLKS WTSFTERTVP PAVTVTCSQA LEGTDNLTCQ AVSFSPQNIS VAWYQDEKAV SPDTQQSGGV LPDGNGTYQT WVTLRVPQGE EQRFSCHVEH GGNHSVHAVP CGEPGGMLE // ID K9J7M2_XENTR Unreviewed; 237 AA. AC K9J7M2; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 12-SEP-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000004543}; DE Flags: Fragment; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000004543, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000004543} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000004543} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099267; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K9J7M2; -. DR PaxDb; K9J7M2; -. DR Ensembl; ENSXETT00000004543; ENSXETP00000004543; ENSXETG00000002125. DR eggNOG; ENOG410JP0A; Eukaryota. DR eggNOG; ENOG410ZMMY; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; K9J7M2; -. DR OMA; PEYTERR; -. DR OrthoDB; EOG091G1N7D; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000002125; Expressed in 9 organ(s), highest expression level in liver. DR ExpressionAtlas; K9J7M2; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 192 215 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 97 182 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSXETP00000004543}. SQ SEQUENCE 237 AA; 26422 MW; 64639CD2EFD76E8E CRC64; AGKDAIHVYQ TKSACVMHED GTISAYQEVA FNGKELIAYD YQMGTFIPTT PEAQVAAQVW NEDYAKIEKV FLENFCTHRL SWYLPALASH LEKLVPPKVK VSISESDSGA ELHCRVYGFY PRDVEVKWIK NGRDEIHSEE AAQILPNPDG TYQIRVSVGV TPEGGATYSC HVEHSSLEKT LVVPFEYNNR SILYIIIPIC GALLLLMIGL GLFLFKKGKK DPNGSYQSGS TETDIEN // ID K9J7Q1_XENTR Unreviewed; 312 AA. AC K9J7Q1; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 12-SEP-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000007870}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000007870, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000007870} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000007870}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000007870} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099298; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099299; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099300; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K9J7Q1; -. DR STRING; 8364.ENSXETP00000007870; -. DR PaxDb; K9J7Q1; -. DR Ensembl; ENSXETT00000007870; ENSXETP00000007870; ENSXETG00000009076. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; K9J7Q1; -. DR OMA; NTRICKA; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000009076; Expressed in 9 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 271 293 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 173 258 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 312 AA; 35481 MW; 493A9B61ED8B6611 CRC64; VVSAPTPGVP QYSIIMYVDG VQYGRYNSDI RQAQSFSPSL NHLSEHLEMQ TKFAQTSEVW QRHKLNFLMG VFNKTKSNGN IHIYQRKCAC ELHDDGTIGG YQEIAFDGKD FLVFDKEKVV YVPVTHEAVM VSHLWNKRYD PTSSKKYMET DCIQHMEMYL PYISTDLEKK VPPKVQISSS ESENGTELHC RVYGFYPRDV EVKWIKNGRD EIHSEEAAQI LPNPDGTYQI RVSVGVTPEG GATYSCHIDH SSLEKALVVP FARHTVAALR FLVIDVVLLL LLLLLIILGI YICRKRKDSR GSYQSGSKES EV // ID K9J800_XENTR Unreviewed; 288 AA. AC K9J800; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 12-SEP-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000019874}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000019874, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000019874} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000019874}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000019874} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099245; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K9J800; -. DR STRING; 8364.ENSXETP00000019874; -. DR PaxDb; K9J800; -. DR Ensembl; ENSXETT00000019874; ENSXETP00000019874; ENSXETG00000009064. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; K9J800; -. DR OMA; RKWEALG; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000009064; Expressed in 10 organ(s), highest expression level in liver. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}. FT DOMAIN 200 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 288 AA; 32702 MW; B2CCFD51C9F2DC83 CRC64; MNIILLSLHN SHCIAGPHIL QYRLTLISTP TPGSPQCTIT AYMDGLNYGR YDSDTGHGQA LVPSLSIPSL AEHREMQTRH ARGVELIQRD KIKFLMGFLN KTNGNGDFHV YQRKFACELH EDGTVRGYEE IAFDGKEFIS VDKERVVYVP VTQEALGITE LWNKRYDLQD NKIYLENECI QHMKMYLPYL STDLERKVPP KVKVSSSESE SGTKLHCRVY GFYPRDVEVK WIKNGRDEIH SEEAAQILPN PDGTYQIRVS VGVTPEGGAT YSCHIDHSSL EKTLVIPF // ID K9J801_XENTR Unreviewed; 329 AA. AC K9J801; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 12-SEP-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000019880}; DE Flags: Fragment; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000019880, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000019880} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000019880} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099283; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099284; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099285; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K9J801; -. DR Ensembl; ENSXETT00000019880; ENSXETP00000019880; ENSXETG00000033941. DR GeneTree; ENSGT00740000114936; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000033941; Expressed in 11 organ(s), highest expression level in heart. DR ExpressionAtlas; K9J801; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 329 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003932441. FT TRANSMEM 311 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSXETP00000019880}. SQ SEQUENCE 329 AA; 37788 MW; E990A3D1E96B9251 CRC64; GNMAGILPLV FLIFSLGTSV VYSGSHTLHY DVTIVSAPTP GVPRYLVSMY VDGVQYGKYN SDIRHAEALY PSLRALSEHI ERQTQYAQEH EMRQRHRLNF LKGYLNTKGK CNGNIYQRRL ACELYEDGTI GGYEEIAFDG KEFFSFDKER VVYVPVTQEA AMLSYLWNIR YDPTDTKIYM ENDCIEHIKL YLPYISTDLE KKIPPKVKVS SSESESGTKL HCRVYGFYPR DVEVKWIKNG RDEIHSEEAA QILPNPDGTY QIRVSVGVTL DKNSNYSCLV DHSSLETPMI VNFVYISFFN IQYTVPNNGR HLYFIISASV ILGIFIYRK // ID K9J802_XENTR Unreviewed; 340 AA. AC K9J802; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 12-SEP-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000019887}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000019887, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000019887} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000019887}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000019887} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099260; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 8364.ENSXETP00000019887; -. DR PaxDb; K9J802; -. DR Ensembl; ENSXETT00000019887; ENSXETP00000019887; ENSXETG00000009068. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; K9J802; -. DR OMA; LVLQSHW; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000009068; Expressed in 10 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 340 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003932572. FT TRANSMEM 296 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 38371 MW; 11911AA3C2C2C233 CRC64; MACIVFLLFG LGIAAVSCRS HTLLYHITVV SAPTPGVPQY SIIMYVDGAQ YGRYNSDIRQ AQFFSPSLSP LSEHLEMQTR YAQAFEVWQR HRLNFLMGVF NKTKGGDRDT HIYQRKAACE LRDDGTSGGY QEIAFDGKEF LAYDKEKVVY IPSTQEAVMV SHLWNKHYSS TNSKMFMEID CIQHMKMYLP YISTDLEKKV PPKVKVSCSS ESGTKLHCRV YGFYPRDVEV KWIKNGRDEI HSEEAAQILP NPDGTYQIRV SVGVTPEGGA TYSCHIDHSS LEKAITVPFE PNKRSILYII PVILASLVLL IALIALGVFI CRKKKDPSGS HQRVSAEDKE // ID K9J803_XENTR Unreviewed; 310 AA. AC K9J803; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 12-SEP-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000019889}; DE Flags: Fragment; GN Name=mhc1b2 {ECO:0000313|Ensembl:ENSXETP00000019889}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000019889, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000019889} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000019889} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099269; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099270; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099271; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSXETT00000019889; ENSXETP00000019889; ENSXETG00000014445. DR GeneTree; ENSGT00740000114936; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000014445; Expressed in 9 organ(s), highest expression level in liver. DR ExpressionAtlas; K9J803; baseline. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 310 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003931376. FT DOMAIN 205 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSXETP00000019889}. SQ SEQUENCE 310 AA; 34936 MW; 027B39B70D0F9642 CRC64; GNMAGILPLV CLIFSLGTSV VYSGDHTLRF HVTKLTAPYP GFPDYMLLAY VDDLRFARYN NELNRCEFWI PALGALNERI TKQKNYTHNF KISHHQKTKL LTDLYNKTSG KDAIHVYQTK SACVMHEDGT ISAYQEVAFN GKELIAYDYQ MGTFIPTTPE AQVAAQVWNE DYAKIEKVFL ENFCTHRLSW YLPALASHLE KLVPPKVKVS ISESDSGAEL HCRVYGFYPR DVEVKWIKNG RDEIHSEEAA QILPNPDGTY QIRVSVGVTP EGGATYSCHV EHSSLEKTLV VPFDPNGSYQ SGSTETDIEN // ID K9J804_XENTR Unreviewed; 202 AA. AC K9J804; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 12-SEP-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000019890}; DE Flags: Fragment; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000019890, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000019890} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000019890} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099267; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSXETT00000019890; ENSXETP00000019890; ENSXETG00000002125. DR GeneTree; ENSGT00740000114936; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000002125; Expressed in 9 organ(s), highest expression level in liver. DR ExpressionAtlas; K9J804; baseline. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}. FT DOMAIN 97 182 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSXETP00000019890}. SQ SEQUENCE 202 AA; 22473 MW; 1F6FF9C939F28BC1 CRC64; AGKDAIHVYQ TKSACVMHED GTISAYQEVA FNGKELIAYD YQMGTFIPTT PEAQVAAQVW NEDYAKIEKV FLENFCTHRL SWYLPALASH LEKLVPPKVK VSISESDSGA ELHCRVYGFY PRDVEVKWIK NGRDEIHSEE AAQILPNPDG TYQIRVSVGV TPEGGATYSC HVEHSSLEKT LVVPFDPNGS YQSGSTETDI EN // ID K9J874_XENTR Unreviewed; 198 AA. AC K9J874; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 12-SEP-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000031604}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000031604, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000031604} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000031604}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000031604} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099269; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099270; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099271; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099272; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSXETT00000031604; ENSXETP00000031604; ENSXETG00000030073. DR GeneTree; ENSGT00740000114936; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000030073; Expressed in 9 organ(s), highest expression level in liver. DR ExpressionAtlas; K9J874; baseline. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}. FT DOMAIN 110 195 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 198 AA; 22269 MW; 704548AF49A3CBDC CRC64; QKTKLLTDLY NKTSGKDAIH VYQTKSACEM HEDGTITAYQ EVAFDGKELI AYDYQTGTFI PTTPEAQIVA QIWNKNYAKI EKIFLEKFCT NRLSKYLNAL ASDLEKLVPP KVKVSSSESE SGTKLHCRVY GFYPRDVEVK WIKNGRDEIH SEEAAQILPN PDGTYQIRVS VGVTPEGGAT YSCHIDHSSL EKTLVVPF // ID K9J892_XENTR Unreviewed; 334 AA. AC K9J892; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 12-SEP-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000035918}; GN Name=LOC100490728 {ECO:0000313|Ensembl:ENSXETP00000035918}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000035918, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000035918} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000035918} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01086742; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01086743; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 8364.ENSXETP00000035918; -. DR PaxDb; K9J892; -. DR Ensembl; ENSXETT00000035918; ENSXETP00000035918; ENSXETG00000030689. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; K9J892; -. DR OMA; NTENPEY; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000030689; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 334 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003932580. FT TRANSMEM 295 318 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 334 AA; 37439 MW; BD59329E50F7834F CRC64; MGIVGFLLLG LGAHIASCGS HILHYCITAV VSDPAYGLPQ YSIVGYVDNL LIGRYSSQTR RPEFLIQSLR DLFEHTEELT RIIHHKENAD TMIMKVILSS LNKTGDGDFH IFQIKYACEL LEDSSISGKE ELALNAKTFI TYNTENPEYI PVVPAALTAA QKWTELYAKL EKDYMEHECV SHLKLYLPYL KKDLEKKVPP KVKVSSSESE SGTKLHCRVY GFYPRDVEVK WIKNGRDEIH SEEAAQILPN PDGTYQIRVS VGVTPEGGAT YSCHTDHSSL EKTLVVPFAE ANNGMLLYIL IALAVTVILL AVLLGVFIHR KRSDRQPVNT EETD // ID K9J893_XENTR Unreviewed; 316 AA. AC K9J893; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 12-SEP-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000035924}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000035924, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000035924} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000035924}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000035924} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01086741; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K9J893; -. DR STRING; 8364.ENSXETP00000035924; -. DR PaxDb; K9J893; -. DR Ensembl; ENSXETT00000035924; ENSXETP00000035924; ENSXETG00000031629. DR eggNOG; ENOG410ITUC; Eukaryota. DR eggNOG; ENOG4111EG6; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; K9J893; -. DR OMA; VTHHPVF; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000031629; Expressed in 10 organ(s), highest expression level in liver. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}. FT DOMAIN 205 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 316 AA; 35713 MW; B0A7A083DE853067 CRC64; TSTLRIPILQ YTCSVCSCCP AGSHTLEYHI ALVSSPGPGV PQSTITAYID GLKYGKYDSD TSRARFLTPS LSSLTEHLDM QTKYAQRFEV IQKHKMEFLM GYLNKTYVNG GFNIYQRKFA CELHEDGTVS GYEEIAYNGK EVMMFDKVRV VYVPASQEAL TMTQQWNQHY NHAKINKIYM ENECIQHMKM YLPYLSTDLE RKVCPKVKVS SSESDGEQKL HCRVYGFYPR DVEVKWIKNG RDEIHSEEAA QILPNPDGTY QIRVSVGVTP EEGATYSCHI DHSSLEKPLV VPFVFKPSSN IVIPIVAALA LALVAL // ID K9J894_XENTR Unreviewed; 329 AA. AC K9J894; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 12-SEP-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000035926}; DE Flags: Fragment; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000035926, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000035926} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000035926} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01086740; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K9J894; -. DR PaxDb; K9J894; -. DR Ensembl; ENSXETT00000035926; ENSXETP00000035926; ENSXETG00000031111. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; K9J894; -. DR OMA; TSRMKIF; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000031111; Expressed in 10 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}. FT DOMAIN 186 283 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSXETP00000035926}. SQ SEQUENCE 329 AA; 37723 MW; 3B1E81A5B14929F4 CRC64; VVLLFSLGVC AVHCGSHTLE YHIALVSSPA PGVPQSTITV YIDGLKYGKY DSETRRARFL TPSLSSLTEH LDMQTKYAQR FEVIQKHKMA FLTGYLNRTY GNGDFHVYQR RFACELHEDG TVSGYEEIAY NGKEVMMFDK ERVVYVPVTQ EVLTMTQQWN QHYNDAKINK IYMENECIHY MKMYLPYIST DLERKVHPEV KVSSSESVSG TKLHCRVYGF YPRDVDVKWI KNERDEIYSE EAAQILPNPD GTYQIRVSVE VTPEEGATYS CHVDHSSLAK PLAVCFGSWK SQDCLVPCNA GLSPLIWIFL FNCVRRRVQP DPCQKCCCT // ID K9J895_XENTR Unreviewed; 200 AA. AC K9J895; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 12-SEP-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000035927}; DE Flags: Fragment; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000035927, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000035927} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000035927} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099324; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K9J895; -. DR STRING; 8364.ENSXETP00000035927; -. DR PaxDb; K9J895; -. DR Ensembl; ENSXETT00000035927; ENSXETP00000035927; ENSXETG00000030515. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR OMA; LENECTQ; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000030515; Expressed in 5 organ(s), highest expression level in liver. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}. FT DOMAIN 84 179 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSXETP00000035927}. SQ SEQUENCE 200 AA; 22636 MW; 328D2EB671151BE8 CRC64; DINHVYQTKA ACVLHEDGTV DVYQEVALDG KQLIVFDKDL VEFVPATQEA VLLTQLWTKH YANAKKDKLF LENECTQHLK LYIPYIKSYL DKKAVPRVKM SNSESGTKLH CRVYGFYPRD VVVKWIKNGR DEIHSEEAAQ ILPNPDGTYQ IRVSVGVTPE GGATYSCHID HSSLEKTLVV PFGDNDLPFS IHSVETETKN // ID K9J8F0_XENTR Unreviewed; 351 AA. AC K9J8F0; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 12-SEP-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000053705}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000053705, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000053705} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000053705}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000053705} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01143684; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K9J8F0; -. DR STRING; 8364.ENSXETP00000053705; -. DR PaxDb; K9J8F0; -. DR Ensembl; ENSXETT00000053705; ENSXETP00000053705; ENSXETG00000025015. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; K9J8F0; -. DR OMA; KTHITHY; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352056; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000025015; Expressed in 5 organ(s), highest expression level in embryo. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 351 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003932584. FT TRANSMEM 309 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 307 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 351 AA; 39956 MW; BEBB4A0E8A16E071 CRC64; DNITMSYIVV LLFSLGVCVV HCGRHTLQYD ISLVSSYSHS VPHYTITAYI DGLQYGRYDS ATRRGQVLIP SMVIPSRSTH LKHMLLQIEF AQKQEVAEKQ KMESLMGFLN KTHGNGEFHV FQRKFACELH KDGTISGYDE IAFDGKELMT FDRERVVHVP VTQEALAMTQ LWNRNYDYAK INKLYMENDC IENMKMYLLY VSTDLERKVL PKVKVSSSES DSGADLHCSV YGFYPRDVEV KWIKNGRDEI HSEEAAQILP NPDGTYQIRV SVGVTPEGGA NYSCHIDHSS LENPMVVPFV SNRRSISQIK IPIMAAFFLI FLALGMLTRM RRNKGSESSQ ESLSSEEENP E // ID L5JR50_PTEAL Unreviewed; 117 AA. AC L5JR50; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 14. DE SubName: Full=HLA class I histocompatibility antigen, B-78 alpha chain {ECO:0000313|EMBL:ELK01397.1}; GN ORFNames=PAL_GLEAN10000061 {ECO:0000313|EMBL:ELK01397.1}; OS Pteropus alecto (Black flying fox). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; OC Pteropodidae; Pteropodinae; Pteropus. OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK01397.1, ECO:0000313|Proteomes:UP000010552}; RN [1] {ECO:0000313|Proteomes:UP000010552} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB093369; ELK01397.1; -; Genomic_DNA. DR ProteinModelPortal; L5JR50; -. DR InParanoid; L5JR50; -. DR Proteomes; UP000010552; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000010552}; KW Reference proteome {ECO:0000313|Proteomes:UP000010552}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 117 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003968406. FT DOMAIN 23 115 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 117 AA; 13523 MW; 06A19F953505910A CRC64; MGLVAPRTLL LLLLALTETW AGFHSLRYFY TAMSRPDSGE PRFLVVGYVD NTQFERFDSD AASPRVETQA PWMKQVEHEE PGYRDRNTRI YENTARTARG SLNILRSYYN QSEAGER // ID L5JTC5_PTEAL Unreviewed; 348 AA. AC L5JTC5; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 33. DE SubName: Full=Hereditary hemochromatosis protein like protein {ECO:0000313|EMBL:ELK02694.1}; GN ORFNames=PAL_GLEAN10005269 {ECO:0000313|EMBL:ELK02694.1}; OS Pteropus alecto (Black flying fox). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; OC Pteropodidae; Pteropodinae; Pteropus. OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK02694.1, ECO:0000313|Proteomes:UP000010552}; RN [1] {ECO:0000313|Proteomes:UP000010552} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB031119; ELK02694.1; -; Genomic_DNA. DR RefSeq; XP_006923543.1; XM_006923481.2. DR ProteinModelPortal; L5JTC5; -. DR GeneID; 102898619; -. DR KEGG; pale:102898619; -. DR CTD; 3077; -. DR InParanoid; L5JTC5; -. DR Proteomes; UP000010552; Unassembled WGS sequence. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010552}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000010552}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 306 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 348 AA; 39244 MW; AC8F06AD9556A6B4 CRC64; MWASAPVLLG PQRPVLSPGA HCLRYLFMGA SNPDLGLPLF KALGYVDDQL FVSYDHESRQ AEPRAAWVRD RVSSQLWLQL SQSLKGWDHM FIVDFWTIMD NCNQSRVTNL EVVPEPHILQ VVLGCEVREG NGTRGFWEYG LDGEDHLTFR PETLDWRAAE PRAQATKLEW EEIRIRAKQN RAYLQRDCPE QLQQLLELGT GVLDQRAPPL VKVTRHVAPT VTTLWCRAQS FYPQNISMRW LKDRQPVAAK DVGPEDVLPS GDGTYQAWVA VATLPGEEWK YTCHVEHPGL AQPLAAAWEP SLPGTLVVGI ISGIGICVII FAAIWFRILR KKQASRAAAA DYVLADRE // ID L5JXD8_PTEAL Unreviewed; 362 AA. AC L5JXD8; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 24. DE SubName: Full=Class I histocompatibility antigen, GOGO-C0101/C0102 alpha chain {ECO:0000313|EMBL:ELK03176.1}; GN ORFNames=PAL_GLEAN10016969 {ECO:0000313|EMBL:ELK03176.1}; OS Pteropus alecto (Black flying fox). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; OC Pteropodidae; Pteropodinae; Pteropus. OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK03176.1, ECO:0000313|Proteomes:UP000010552}; RN [1] {ECO:0000313|Proteomes:UP000010552} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB031114; ELK03176.1; -; Genomic_DNA. DR ProteinModelPortal; L5JXD8; -. DR InParanoid; L5JXD8; -. DR Proteomes; UP000010552; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010552}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000010552}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 301 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 41074 MW; 91041288E185DA72 CRC64; MHSFPATQRL FAPITPRAGR AAAGTHSLRY HYLALSEPGP GLPQFLAVGY VDDHPFIRYD SRVGRAEPQA RWMAPVDAQY WETETQKQRA WAEVQQVETW TVMGYRNHTS GMHSTQRMFG CNIQEDGRSS SFWQFGFDGQ DHLSLDLETL SWVSAEPMAM RTKRWWELER CYAEYDKAYL EGLCLTSLRR YLELGGQHLT RKEPPTVYVT RHSTEDRGTT LRCWALGFYP RDISLRWWLG EEELALETEH VETRPSGDGT YQMWAAVRVP AGEEAGYTCH VQHSGLNHTL TVAWEPPSRH GLTAMVISSI LLLLAVGVVI LTKRFLQGEE TEAQGPMAGS CHSRDMRSGT SPLHLSDNCA VL // ID L5K5J8_PTEAL Unreviewed; 622 AA. AC L5K5J8; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 22-NOV-2017, entry version 26. DE SubName: Full=Zinc-alpha-2-glycoprotein {ECO:0000313|EMBL:ELK06959.1}; GN ORFNames=PAL_GLEAN10012118 {ECO:0000313|EMBL:ELK06959.1}; OS Pteropus alecto (Black flying fox). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; OC Pteropodidae; Pteropodinae; Pteropus. OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK06959.1, ECO:0000313|Proteomes:UP000010552}; RN [1] {ECO:0000313|Proteomes:UP000010552} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB030994; ELK06959.1; -; Genomic_DNA. DR ProteinModelPortal; L5K5J8; -. DR InParanoid; L5K5J8; -. DR Proteomes; UP000010552; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 2. DR Pfam; PF00129; MHC_I; 2. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 2. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS00290; IG_MHC; 2. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010552}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000010552}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 622 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003968890. FT DOMAIN 205 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 517 602 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 622 AA; 71438 MW; 825B5C90988167C6 CRC64; MSTIVPVLLS LLLLLSPAVS QETQDGPYSL TFHSIGVSTL AEGLPGFQAT GFLNDQPFFH YDIESGKAEP LGPWRQVEGM EDWEEVSKRQ KARGDFFLKN LKDIMDYKKD RGNHTMQEKF GCKLRNNTYC GAFWTVAYDG QDYIKFNTEI PAWIPLQKAA LNTKVKWETE GSVQRAKASL KEECPQMLRR YLQYSRIYLD RQDPPSVSIT SYVGPRNKRT LRCLAYNFYP QPISLYWTRA SNVVENELWG DVALSENGTY QSWVSVKIPS RDTGPYFCHV QHSSLAQPLT VPWNERQELQ DLGKSSTFLP GTTSTMVPVL FSLLLLLSPA VSQETQDGPY SLSYLYTGVS RPAKGLPGFQ ATGFLNDQPF FHYDSESGKA EPLGPWKQVE GMEDWEKESK LQKARGDFFL KNLKDIMDYK KDRGNHTFQG RFGCELRNNT YCEAFWRYAY DRRDYIKFNT EIPAWIPLQK AALNTKVKWE TEGSVQAAKN YLEDECPQIL QKYLQYSKNY LDRQDPPSVS ITSYVGPRNK RTLRCLAYNF YPQPISLYWT RASNVVENEL WGDVALSENG TYQSWVSVKI PSRDSGPYFC HVQHSSLAQP LTVPWNERQE VRVEDAAESQ NQ // ID L5KCC7_PTEAL Unreviewed; 215 AA. AC L5KCC7; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 15. DE SubName: Full=NKG2D ligand 3 {ECO:0000313|EMBL:ELK09339.1}; GN ORFNames=PAL_GLEAN10003537 {ECO:0000313|EMBL:ELK09339.1}; OS Pteropus alecto (Black flying fox). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; OC Pteropodidae; Pteropodinae; Pteropus. OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK09339.1, ECO:0000313|Proteomes:UP000010552}; RN [1] {ECO:0000313|Proteomes:UP000010552} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB030829; ELK09339.1; -; Genomic_DNA. DR ProteinModelPortal; L5KCC7; -. DR InParanoid; L5KCC7; -. DR Proteomes; UP000010552; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000010552}; KW Reference proteome {ECO:0000313|Proteomes:UP000010552}. FT DOMAIN 39 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 215 AA; 23986 MW; F7A64EDF4DA15307 CRC64; MTLMMGTGIA HNQRPQSTGP GALPGTSLNG VDVSVANAHS LHYDFSISSN RQPRCKVQGQ LDGNDFLSYD CDNNVISVNH LREKVNATDF WEEQIGTLKD VGDLLKQELP DIKPEQNTDS VPLTLQVRMM CQREARGRPS GSWEFAFNGQ KLLIFDAENT EYTVVHSGGE RMKNKWKPNQ DVTKAFKTIS EGDCSKWLNV LRQEAAERTA ETRGS // ID L5KYE2_PTEAL Unreviewed; 331 AA. AC L5KYE2; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 20-DEC-2017, entry version 26. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ELK16210.1}; GN ORFNames=PAL_GLEAN10017702 {ECO:0000313|EMBL:ELK16210.1}; OS Pteropus alecto (Black flying fox). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; OC Pteropodidae; Pteropodinae; Pteropus. OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK16210.1, ECO:0000313|Proteomes:UP000010552}; RN [1] {ECO:0000313|Proteomes:UP000010552} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB030474; ELK16210.1; -; Genomic_DNA. DR ProteinModelPortal; L5KYE2; -. DR InParanoid; L5KYE2; -. DR Proteomes; UP000010552; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000010552}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000010552}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 288 313 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 194 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 152 172 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 331 AA; 38275 MW; 29A76107C5EA9B66 CRC64; MFIKGLAWYP AHGTHSLRYF RLGVSEPGHG IPEFISVGYV DSYPITTYDS ISRVKKPQAP WVAENLAPDH WERYTQLLRS WQRTFKMELK HLQSHYNHSG LHTYQRMIGC ELREDGNTTG FLQYAYDGQD FIIFNKDTLS WIAVDNAAHI TKRAWEANRH ELQYQKNWLE EECIAWLKRL LEYGKDTLQR TEAPLVRINR KETFPGITTL FCRAHGFYPP EISMIWMKNG KEMLQEMDYG DILPSGDGTY QTWVSLDLDP QSSDSYSCHV EHCDVHMVLQ VPQESETILL VMKAVTGSVV LAIGLAGVGV LAWRRRLREQ NGITYLPTSD Q // ID L5L486_PTEAL Unreviewed; 454 AA. AC L5L486; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 28-FEB-2018, entry version 25. DE SubName: Full=IgG receptor FcRn large subunit p51 {ECO:0000313|EMBL:ELK18534.1}; GN ORFNames=PAL_GLEAN10004545 {ECO:0000313|EMBL:ELK18534.1}; OS Pteropus alecto (Black flying fox). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; OC Pteropodidae; Pteropodinae; Pteropus. OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK18534.1, ECO:0000313|Proteomes:UP000010552}; RN [1] {ECO:0000313|Proteomes:UP000010552} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB030309; ELK18534.1; -; Genomic_DNA. DR ProteinModelPortal; L5L486; -. DR InParanoid; L5L486; -. DR Proteomes; UP000010552; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010552}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:ELK18534.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000010552}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 397 420 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 301 388 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 454 AA; 50352 MW; 5B8686E76060E6DF CRC64; MRTKGIARRQ TLTMHRLEAR WSRPAGFIPR GLALRAPRSL PPMPVPGTAA HHWYKGWETG PWGEEAASGS AQRLLFTLAQ EGGGSCQRKW GRIKEGRKGQ GQVRGGHRPN FSLQQARPAL GQRDSYRSLL YHLTCVSSPA PGTPAFWVSG WLGPQQYLSY NNLRAQAEPC GAWVWENQVS WYWEKETTDL RQKQKLFLEA FTVLEKSGSY TLQGLLGCEL GPDNVSVPVA KFALNGEDFM TFDPKAGTWS GDWPEAQTIS EHWKHQEEAV NKEKTFLLYS CPQRLLGHLE RGRGNLEWKE PPSMRLKARP GSPGFSVLTC SAFSFYPPEL QLRFLRNELA VGSGESHLGP NSDGSFHAWS SLTVKSGDEH HYRCLVQHVG LPQPLTVELE SPARSSMAVV GIVIGVLLFV ALVIGGVLLW RRMQTGMPAP WISLRADDGG ALLPTPGLPK DADS // ID L5L7M4_PTEAL Unreviewed; 101 AA. AC L5L7M4; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=CHLA class I histocompatibility antigen, A-5 alpha chain {ECO:0000313|EMBL:ELK19642.1}; GN ORFNames=PAL_GLEAN10000038 {ECO:0000313|EMBL:ELK19642.1}; OS Pteropus alecto (Black flying fox). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; OC Pteropodidae; Pteropodinae; Pteropus. OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK19642.1, ECO:0000313|Proteomes:UP000010552}; RN [1] {ECO:0000313|Proteomes:UP000010552} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB031501; ELK19642.1; -; Genomic_DNA. DR ProteinModelPortal; L5L7M4; -. DR Proteomes; UP000010552; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000010552}; KW Reference proteome {ECO:0000313|Proteomes:UP000010552}. FT DOMAIN 3 45 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 101 AA; 11841 MW; AA9F75BA99579C39 CRC64; MERPWVEQED PQYWERETQI SRNNAETFRV DFKTLRGYYN QSEAGERRDG PRSRPPSPRT GRGRPRVRAR ASPRGCGTRR EEPAGTPRVS LSVWVRSLRR G // ID L5LAL0_MYODS Unreviewed; 186 AA. AC L5LAL0; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 15. DE SubName: Full=Patr class I histocompatibility antigen, A-2 alpha chain {ECO:0000313|EMBL:ELK23364.1}; GN ORFNames=MDA_GLEAN10005608 {ECO:0000313|EMBL:ELK23364.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK23364.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB113694; ELK23364.1; -; Genomic_DNA. DR ProteinModelPortal; L5LAL0; -. DR Proteomes; UP000010556; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 126 149 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 77 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 186 AA; 20799 MW; DC99D45276740CBD CRC64; MGSDGSFLRG YDQFAYDGAD YITLNEDLRS WTAASEVAQL SLRKYEAVDE AEVQRNYLER VCMEWLRRYL EKGRDILQRA DPPKAHVTRH PVGGTPGEEQ RYTCHVQQEV LPEPLTLRWE PPPQTFIFII MGIAGGLVLL GAVAGAVMWE TRRSGGDSSW GSDVLLKASK VTTREQTLNA GAAELQ // ID L5LCF1_MYODS Unreviewed; 251 AA. AC L5LCF1; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 22. DE SubName: Full=Patr class I histocompatibility antigen, A-2 alpha chain {ECO:0000313|EMBL:ELK23887.1}; GN ORFNames=MDA_GLEAN10005074 {ECO:0000313|EMBL:ELK23887.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK23887.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB113177; ELK23887.1; -; Genomic_DNA. DR ProteinModelPortal; L5LCF1; -. DR Proteomes; UP000010556; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 184 208 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 88 176 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 251 AA; 28059 MW; 5482D01E397F3269 CRC64; MYGCDISPDG RLLHGYRQFA YDGVDYLALN EDLTSWTAAD MAAQITKSKW EATRFHERRS NYLEGECMQW LRLYLEKGKE ILQRAVPPKT HVTHHPVSDH EVTLRCWALG FYPADISLTW QRDGEDQTQD MELLETRPAG DGTFQKWAAV GVPPGEEQRY TCHVQHEGLP EPLTLRWEPP SQTFIFIIMG IAGGLVLLGA MAGAVMWWRR HSGAKGGSYA QAASEYGGGT PESLGQSMHE PMGSSPPKVP P // ID L5LFA4_MYODS Unreviewed; 222 AA. AC L5LFA4; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 22. DE SubName: Full=Patr class I histocompatibility antigen, A-126 alpha chain {ECO:0000313|EMBL:ELK24556.1}; GN ORFNames=MDA_GLEAN10001532 {ECO:0000313|EMBL:ELK24556.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK24556.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB112782; ELK24556.1; -; Genomic_DNA. DR ProteinModelPortal; L5LFA4; -. DR Proteomes; UP000010556; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 222 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003970151. FT DOMAIN 128 216 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 222 AA; 24769 MW; 5EE815167D7830E6 CRC64; MRLQSHPTLL LLLSGALVLT PSWAGGADRG AGSGSHTFQR MIGCDLGPDG RLLRGYLQYA YDGADYIALN EDLTSWTTAD MAAQITRRKW EAAGGAELVR SYLEGECMEW LQIHLEKGKE TLQRTDPPKA HVTHHPVSER EVTLRCWALG FYPADISLTW QRDGEDQTQD MELVETRPAG DGTFQKWAAV GVPPGEEQRY TCHVQHEGLP EPLTLRWVEE GP // ID L5LFU0_MYODS Unreviewed; 215 AA. AC L5LFU0; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 15. DE SubName: Full=Class I histocompatibility antigen, B alpha chain {ECO:0000313|EMBL:ELK25204.1}; GN ORFNames=MDA_GLEAN10000400 {ECO:0000313|EMBL:ELK25204.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK25204.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB112142; ELK25204.1; -; Genomic_DNA. DR ProteinModelPortal; L5LFU0; -. DR Proteomes; UP000010556; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 2. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 158 181 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 3 45 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 67 148 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 191 215 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 215 AA; 24062 MW; 33929ACFCF1730DA CRC64; MQQPWVERVY LGYWEEQTQI FKAAAQTYRG NLEILRGHYN QSEDGEPRAG PVTTPLPTDG PGSPRGACGC DVGPDGRLFR GYSQWAYDGA DYITLNEDMN SWTSSDLAAQ ITGRKWEAEG EAERVRSYLE GLCVESLLIY VEKGKETLQR AELPSQTFIF IIMGIAGGLV LLGAVAGAVM WGRRRSGIIL CEEILKKEKW AEEEEEEEEE EEEGS // ID L5LJH9_MYODS Unreviewed; 211 AA. AC L5LJH9; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 25. DE SubName: Full=Patr class I histocompatibility antigen, A-2 alpha chain {ECO:0000313|EMBL:ELK26499.1}; GN ORFNames=MDA_GLEAN10000252 {ECO:0000313|EMBL:ELK26499.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK26499.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB111025; ELK26499.1; -; Genomic_DNA. DR ProteinModelPortal; L5LJH9; -. DR Proteomes; UP000010556; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 184 208 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 88 176 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 211 AA; 23912 MW; B254E9362E43137C CRC64; MIGCDLGPDG RLLRGYLQYA YDGADYIALN EDLTSWTTAD MAAQITRRKW EAAGGAELVR SYLEGECMEW LQIHLEKGKE TLQRTDPPKT HVTHHPVSEH EVTLRCWALG FYPADISLTW QRDGEDQTQD MELVETRPAG DGTFQKWAAV RVPPGEEQRY TCHVQHEGLP EPLTLRWEPP SHTFIFIILG IAGGLVLLGA VAGAVMWWRR R // ID L5LK86_MYODS Unreviewed; 204 AA. AC L5LK86; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 28-FEB-2018, entry version 23. DE SubName: Full=Class I histocompatibility antigen, Gogo-B*0103 alpha chain {ECO:0000313|EMBL:ELK26779.1}; DE Flags: Fragment; GN ORFNames=MDA_GLEAN10000506 {ECO:0000313|EMBL:ELK26779.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK26779.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB110832; ELK26779.1; -; Genomic_DNA. DR ProteinModelPortal; L5LK86; -. DR Proteomes; UP000010556; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 171 194 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 88 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 114 156 IGc1. {ECO:0000259|Pfam:PF07654}. FT NON_TER 1 1 {ECO:0000313|EMBL:ELK26779.1}. SQ SEQUENCE 204 AA; 22424 MW; 1C22CC2FE3767F2A CRC64; SHTFQWMVGC EVGPDGRLLR GYWQFAYDGA DYIALNEDLT SWTAADMAAQ ITWLKWEAAG EAERARSYLE GRCVESLLMT LDKGKETLQR AGTRVTGAAP SPRGWGSYKE TGQGTQDLEL VETRPAGDGT FQKWAAVGVP TGEEQRYTCH VQHEGLPAPL TLRWEPPSHT FFIIIMGIAG VLVLLGAVAT AVMWGRRRHS GGQV // ID L5LNP6_MYODS Unreviewed; 130 AA. AC L5LNP6; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 14. DE SubName: Full=Class I histocompatibility antigen, Gogo-C*0101/C*0102 alpha chain {ECO:0000313|EMBL:ELK27667.1}; GN ORFNames=MDA_GLEAN10001691 {ECO:0000313|EMBL:ELK27667.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK27667.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB109949; ELK27667.1; -; Genomic_DNA. DR ProteinModelPortal; L5LNP6; -. DR Proteomes; UP000010556; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 130 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003970418. FT DOMAIN 29 115 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 130 AA; 13849 MW; 5C3CA1BE9832DA5E CRC64; MRVMKSPTPL PLLSGALVLT PTWAAPLHGS EDGSHTFQVV YGCDVGPTDA SHAGHCGQSA YEGAGCSALN EDLTSRTAAH VAAPITCDAE HPKSYLKGSR MEWLRVFLEK GKETLQRADP PSTWDPPPPL // ID L5LP00_MYODS Unreviewed; 368 AA. AC L5LP00; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 28-MAR-2018, entry version 32. DE SubName: Full=Patr class I histocompatibility antigen, A-126 alpha chain {ECO:0000313|EMBL:ELK27806.1}; GN ORFNames=MDA_GLEAN10000501 {ECO:0000313|EMBL:ELK27806.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK27806.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) CC family. {ECO:0000256|RuleBase:RU000488, CC ECO:0000256|SAAS:SAAS00548220}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB109802; ELK27806.1; -; Genomic_DNA. DR ProteinModelPortal; L5LP00; -. DR Proteomes; UP000010556; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 1.50.40.10; -; 1. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier. DR InterPro; IPR023395; Mt_carrier_dom_sf. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR Pfam; PF00153; Mito_carr; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF103506; SSF103506; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50920; SOLCAR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00013441, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Transmembrane {ECO:0000256|SAAS:SAAS00013441, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00013441, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000488}. FT TRANSMEM 239 263 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 134 227 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT REPEAT 267 359 Solcar. {ECO:0000256|PROSITE- FT ProRule:PRU00282}. SQ SEQUENCE 368 AA; 41527 MW; 7B2663EC2BA70F1C CRC64; MEQVEPGYWD RSTRNAKDSA QTFRRNLHNL RGYYNQSEDG SHTLQLLFGC DMGPDGRLLR GYHQYAYDGT DYIALNEDLR SWTAANTAAQ ITRRKWEENG DAKERRHYLQ GECLEWLRRY LALGKEALQR ADPPKTHVTH HPISDREVTL RCWALGFYPA DISLSWQRDG EEQTQDMEFV ETRPAGDGTF QKGAALGVPP GEEFLGEEQR STCHVQQEGL PEPLTLRWEP PPQATIPPVG LIVGLVILGA VVIGAVVIGA VMWRRKHSGS NGAQGSDVSL TASKDGHGPM ERVKLLLQVQ HASQQSTSNK QYKDIMDCIM HIPKEQGVLC FCRGNMANVI HYFPTQALNF AFKNKYKQVF LGGTDFHM // ID L5LRM9_MYODS Unreviewed; 205 AA. AC L5LRM9; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 28-FEB-2018, entry version 28. DE SubName: Full=Patr class I histocompatibility antigen, A-2 alpha chain {ECO:0000313|EMBL:ELK29084.1}; GN ORFNames=MDA_GLEAN10000167 {ECO:0000313|EMBL:ELK29084.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK29084.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB108411; ELK29084.1; -; Genomic_DNA. DR Proteomes; UP000010556; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 144 168 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 48 136 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 205 AA; 22545 MW; 2FB1F03A1B4A997E CRC64; MAAQITKRKW EAAGVAERER RFLEGECVKW LRTHLDKGKE TLQRADPPKA HVTHHPVSAH EVTLRCWALG FYPADISLTW QRDGEDQTQD MELVETRPAG DGTFQKWAAV GVPPGEEQRY TCHVQHEGLP EPLTLRWEPP SQTFIVFIIL GIAGGLVLLG TMASAVMWGR RRSGGSGGSY AQAASSDSAQ GSDVSLWASK GETLP // ID L5LSU3_MYODS Unreviewed; 126 AA. AC L5LSU3; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 14. DE SubName: Full=Patr class I histocompatibility antigen, B-1 alpha chain {ECO:0000313|EMBL:ELK28523.1}; GN ORFNames=MDA_GLEAN10000479 {ECO:0000313|EMBL:ELK28523.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK28523.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB109128; ELK28523.1; -; Genomic_DNA. DR ProteinModelPortal; L5LSU3; -. DR Proteomes; UP000010556; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 91 117 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 77 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 126 AA; 14222 MW; 75AD97B03E3A9FB9 CRC64; MGPDGRLLRG YHQYAYDGTD YIALNQDLRS WTAANTAAQI TWRKWEATGE AEERRHFLQG ECLEWLHRYL EKGKEVLQRT EPPPQATFPS VGLVVGLVIL GAVLTGAVVT GAGHWTWSLE LWSLEL // ID L5LX25_MYODS Unreviewed; 316 AA. AC L5LX25; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 23. DE SubName: Full=Patr class I histocompatibility antigen, A-2 alpha chain {ECO:0000313|EMBL:ELK30661.1}; GN ORFNames=MDA_GLEAN10006736 {ECO:0000313|EMBL:ELK30661.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK30661.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB106698; ELK30661.1; -; Genomic_DNA. DR ProteinModelPortal; L5LX25; -. DR Proteomes; UP000010556; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 3. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 269 290 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 172 260 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 316 AA; 35863 MW; E8F24F259ACDF6BF CRC64; MGPDGRLLRG YDQSAYDGTD YLALNEDLRS WTAADTAAQI TRRKWEAEAR APWMEQEEPG YWDLNTRNAQ VAAQSFRLNL DILRGYYNQS REGEPRGPGL GPCHDPHPHG RTFVALSVRV RASPTAAQIT RRKWEAEGVA EERRHYLQGE CLEWLRRYLA MGKEALQRAD PPKTHVTHHP ISDLEVTLRC WALGFYPADI SLSWQRDGEE QTQDMELVET RPAGDGTFQK WAALVVPRGE EQRYTCHVQH EGLPEPLTLR WEPSPWATIP PVCLVCLVIL GAVVTGAVMW RRKRSGSYST QSSDLSLLAF KGKTPM // ID L5LXA4_MYODS Unreviewed; 302 AA. AC L5LXA4; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 17. DE SubName: Full=HLA class I histocompatibility antigen, B-78 alpha chain {ECO:0000313|EMBL:ELK30660.1}; GN ORFNames=MDA_GLEAN10006735 {ECO:0000313|EMBL:ELK30660.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK30660.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB106698; ELK30660.1; -; Genomic_DNA. DR Proteomes; UP000010556; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 302 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003970708. FT TRANSMEM 214 238 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 23 200 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 244 259 MHC_I_C. {ECO:0000259|Pfam:PF06623}. SQ SEQUENCE 302 AA; 34037 MW; DCDA3C50C7C9877C CRC64; MRSQALLLLL WVPLAMTETW AGPHSLRYFY TALSRPDQPR PRFVIVGYVD DTQIERFDSD SEGPRAEPRA PWMEQVEPGY WDRSTRNAKD SAQTFRRNLH NLRGYYNQSE DGSHTLQLLF GCDMGPDGRL LRGYHQYAYD GTDYIALNQD LSSWTAADMA AQITQRKWEE NGEAEERRHY LQDDCLELLS RYLTMGKETL KRTEPPLQAT IPPVGLVVGL VILGAVVTGA VVTGAVMWRR KRSGSDSSQG SDVSLIASKD PLRLRRPPIG SETILGTSLA RSAKISSVGA SFWDERQKKR AS // ID L5LY35_MYODS Unreviewed; 294 AA. AC L5LY35; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 23. DE SubName: Full=Zinc-alpha-2-glycoprotein {ECO:0000313|EMBL:ELK30991.1}; GN ORFNames=MDA_GLEAN10001256 {ECO:0000313|EMBL:ELK30991.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK30991.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB106577; ELK30991.1; -; Genomic_DNA. DR ProteinModelPortal; L5LY35; -. DR Proteomes; UP000010556; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 294 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003970674. FT DOMAIN 202 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 294 AA; 33495 MW; 5C0087C0C3376DD4 CRC64; MVPVLLSLLL AVGPAVTQDT QNRPYSLTYH SNGVSKPKEG FPSFQATGYL NDQAFFHYDS ETEKAEPLGP WKQVEGMEDW EELSKFQKAR GDFFLKNLKD IMGYYKDTGN HTMQEKYGCK LQNNNYCGAF WTVAYDGRDY IKFDTEIPAW IPLQPEALKT KVKWETEGSV QRAKASLEEE CTGKLQKYLQ FSRPFLDRQD PPSVSITSHV NPGNIRTLKC VADNFYPKPI SMYWTQADSV VETESWGEGP LSENGTYQSW VVVKILSLDR GPYSCHVQHS SLAQPLTVTW NESQ // ID L5LYX3_MYODS Unreviewed; 117 AA. AC L5LYX3; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 28-FEB-2018, entry version 15. DE SubName: Full=HLA class I histocompatibility antigen, B-73 alpha chain {ECO:0000313|EMBL:ELK30663.1}; GN ORFNames=MDA_GLEAN10006738 {ECO:0000313|EMBL:ELK30663.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK30663.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB106698; ELK30663.1; -; Genomic_DNA. DR ProteinModelPortal; L5LYX3; -. DR Proteomes; UP000010556; Unassembled WGS sequence. DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR002067; Mit_carrier. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR00926; MITOCARRIER. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}. FT DOMAIN 1 48 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 117 AA; 12480 MW; 0FAD28A309B9B153 CRC64; MGPDGRLLRG YYQFAYDGTD YIALNEDLRS WTAANTAAQI TRRKLEEALD GGCSAEPGAP KLLAPLRAST LLRAPGSPCC AARMEQAISF AKDFLAGGFP AAISMTAVAP MERVKLL // ID L5M814_MYODS Unreviewed; 528 AA. AC L5M814; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 25. DE SubName: Full=Popy Class I histocompatibility antigen, A-1 alpha chain {ECO:0000313|EMBL:ELK33868.1}; GN ORFNames=MDA_GLEAN10002953 {ECO:0000313|EMBL:ELK33868.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK33868.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB103628; ELK33868.1; -; Genomic_DNA. DR Proteomes; UP000010556; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 493 515 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 396 484 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 528 AA; 58469 MW; D9D8D330A5C946C6 CRC64; MSQVCTCCGL RASILPVPVR PASKDSQCAR GVGAGTCAST RRGAALPFPP PALLPASLLL LXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXCV LTPSWAGPHS LRYFYTIVSR PGRREPRFLS VGYVDDTQFV RFDSDAASPR MEPRAPWMQQ PWVEREMSGY WDRNTQISKE TAQTYRVGLQ SLRGYYNQSE DGPHTLQRMS GCDVGLDGRL LRGYEQYAYD GGDYIALNED LTSWTAADTA AQITRRKWEA VGAAERYRSY LEGLCVESLF MYLDRGKETL QRADPPKAHV THHPVSAREV TLRCWALGFY PADIALTWQR DGEDQTQDME LVETRPAGDG TFQKWAAVGV PPGEEQRYTC HVQHEGLPEP LTLRWEPPTQ TSIIVIMGIA GGLVLLGAVA GAVLCGRRRL GGNGGSYA // ID L5ME21_MYODS Unreviewed; 309 AA. AC L5ME21; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 21. DE SubName: Full=HLA class I histocompatibility antigen, A-32 alpha chain {ECO:0000313|EMBL:ELK36577.1}; GN ORFNames=MDA_GLEAN10000641 {ECO:0000313|EMBL:ELK36577.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK36577.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB101456; ELK36577.1; -; Genomic_DNA. DR ProteinModelPortal; L5ME21; -. DR Proteomes; UP000010556; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 2. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 173 195 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 82 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 124 158 IGc1. {ECO:0000259|Pfam:PF07654}. FT DOMAIN 200 274 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 309 AA; 34286 MW; A66FD889520BE848 CRC64; MRSCYMRPDG SLLRGYYQYA YDGADYISLN EDLTSWTAAD AVAQITKRKW EATGFAKVMR HYLQGACLKW LRIHLEKGKE TLLRTGSRGP GATPSPRGWG SYKETGQGIS VRHPSLVLGM VLVETRPAGD GTFQKWAAVG VPPGEEQRYT CHVQHEGLPE PLTLRWEPPS QTFVIIMSIA GGLVLLGAVA GAVIWRNRHS DGRLLQSYDQ VAYDGADYIA RNEDLRSWTA TDMAAQITRC KWEAAGEAEE MRSYLEGPCM GWLHLYLEKW KETLQPAGTR GPGAGPSPRG WGSYKETGQG VRVRHPSLG // ID L5MFG1_MYODS Unreviewed; 353 AA. AC L5MFG1; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 24. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ELK37131.1}; GN ORFNames=MDA_GLEAN10016458 {ECO:0000313|EMBL:ELK37131.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK37131.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB100891; ELK37131.1; -; Genomic_DNA. DR ProteinModelPortal; L5MFG1; -. DR Proteomes; UP000010556; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 309 335 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 215 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 353 AA; 41112 MW; 3979373916D6CC7B CRC64; MSIRGSWDRQ PRPFEKQFYW PEQTKFRIVD FSSIRTHSLR YFRLGVSEPG HGIPEFLSVG YVDSHPITTY DSVSRLKEPQ APWMAEHLAP DHWERYTQLL RGWQQTFKVE LERLQRHYNH SGFHTYQRMI GCELLEDGST TGFLQYAYDG QDFIIFDKDT LSWTAVDNVA HITKRAWEAN WHELQYQKNW LEEECIAWLK RFLEYGKDTL QRTEPPLVKV SRKETFPGIT TLVCRAYGFY PPEISMIWMK NGEEMIQEMD YGGILPSGDG TYQTWVSVEL DSESNDLYSC HVEHSDVQMV LQVPQGSEAI LLVVKAVSGS IVLAMVLAGV GCLAWRRRPQ EKNEVIYLPA PDQ // ID L5MGT2_MYODS Unreviewed; 389 AA. AC L5MGT2; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 28-FEB-2018, entry version 19. DE SubName: Full=HLA class I histocompatibility antigen, A-36 alpha chain {ECO:0000313|EMBL:ELK36958.1}; GN ORFNames=MDA_GLEAN10000710 {ECO:0000313|EMBL:ELK36958.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK36958.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB100902; ELK36958.1; -; Genomic_DNA. DR Proteomes; UP000010556; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 3. DR Pfam; PF06623; MHC_I_C; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 3. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 269 293 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 244 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 389 AA; 42485 MW; 64DFF256855CECB9 CRC64; MEQEEPGYWV RSTRNAKVSA QIFLESLHNL RGYYNQSRDG GRIRLAHTRE EPAGTWTRFT LSFCLIPPGG SGSHTLQLMY GCEMGPDGRL LHGYHQSAYD GTDYIALNED LRSWTAADVA AQITRGKLEA AGEAELYAYD GTDYIALNQD LSSWTAADMA AQITQRKWEE NGEAEERRHY LQDDCLELLS RYLTMGKETL KRTDPPKTRV THHPISDREV TLRCWALGFY PADISLSWQR DGEEQTQDME FVETRPAGDG PPWATIPPVG LVVGLVILGA VLTGAVVTGA VMWRRKRSGG KGGSYAQAAS SDSAHGSDVS LTASKDHLVV DQGKSGAERQ FKSLVGCLVQ ISKSDSIGAC TTVSTSLCKA SSSTGQLLRG VGHSQSHAP // ID L5MIU7_MYODS Unreviewed; 186 AA. AC L5MIU7; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 25-OCT-2017, entry version 17. DE SubName: Full=Ras-like GTP-binding protein RHO {ECO:0000313|EMBL:ELK38205.1}; GN ORFNames=MDA_GLEAN10000637 {ECO:0000313|EMBL:ELK38205.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK38205.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB099224; ELK38205.1; -; Genomic_DNA. DR ProteinModelPortal; L5MIU7; -. DR Proteomes; UP000010556; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR027417; P-loop_NTPase. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 52 75 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 42 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 186 AA; 19943 MW; C81EEA8A817C4832 CRC64; MAAQISKRKW EAAGVAERDR IYLEGTCMEW LCMYLEKGKE TLQRAEPPSQ TFIFIIMGIA GGLVLLGAVA GAVMWGRRRS EVQGPPVHGN EGAGMEGGGE QAERALGGTA GQEEDGGWRP LSCPDTDVLW LCLSTDSPEC LENIPEKGPQ QVKRFCPQGP IVLAGSQEGL GKDEPTGGSS QLQQEQ // ID L7MZP5_ANOCA Unreviewed; 357 AA. AC L7MZP5; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 12-SEP-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000006366}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000006366, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000006366} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000006366}; RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000006366} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; L7MZP5; -. DR Ensembl; ENSACAT00000006508; ENSACAP00000006366; ENSACAG00000006478. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; L7MZP5; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000006478; Expressed in 4 organ(s), highest expression level in heart. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 357 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003982192. FT TRANSMEM 307 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 357 AA; 40264 MW; 6F2C2A974A614E82 CRC64; MGLSRKEPFL LLLGVSALLL GGSAGSSSHS LRYFATIVSE PGQEVPQFFS VGYVDDQQFV SYDAKAKRRV PAVPWIRKVD KDDPQYWERN SQIVWNTEQV FRGSLVNNAR YYNQSGGSHT WQQMYGCELR GDGSKGGYRQ FAYDGRDYIS FDKETLTYTA ADVPAQNTKR KWEAEPAIAQ GRKVYLEEIC IEWLQRYLDY GKESLLRTDK PEVKVTRKED YDGMETLICR VGGFYPKEID ITWTKDGEVW MQDVFHGLVS PNSDGTYYTW RSVMVDPKES ERYKCHVEHD GLPNPVDVAW EEPDSNLGII IGCVVGVLLL IGVMAGIYFK KRQDGYKAAA ASDQGSNSSG TGTAVPI // ID L7MZR7_ANOCA Unreviewed; 359 AA. AC L7MZR7; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 12-SEP-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000007706}; DE Flags: Fragment; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000007706, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000007706} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000007706} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; L7MZR7; -. DR STRING; 28377.ENSACAP00000007706; -. DR Ensembl; ENSACAT00000007871; ENSACAP00000007706; ENSACAG00000022634. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; L7MZR7; -. DR OMA; CFILENA; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000022634; Expressed in 4 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}. FT DOMAIN 212 300 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSACAP00000007706}. SQ SEQUENCE 359 AA; 41579 MW; CA9A6A5896A2A1EB CRC64; KDVPIIKLCF ILENAALAEL RRCFSSSSSH SLRYFYTAAS EDNKWLSSFI IVGYVDDQRI CQYDSIVREK RACVPWMSKV EEEDPSYWAE ETEVSRNAEV FFKVSLVTAN NRYNQSGGFH TLQQMYGCDL RKDESKGGYR QYAYDGKDFI SFDKETLTWT AADVEAQITK RRWDAQSTRN QYLKAYLEEE CIKWLQKYLE YGNETLLRTE KPEVKVTRKV DYDGMETLIC RVGGFYPKDI DIEWTRDGEV WMQDTFHGLV SPNSDGTYYT WRSITVDPKE RERYKCHVEH DGLPSPVDVA WEDPVSKSVL IGCAVGILLP ITGLAVYFQK HQDDYKTVSG SDKKSNTSKE GKFTAERVE // ID L7MZX2_ANOCA Unreviewed; 364 AA. AC L7MZX2; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 12-SEP-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000010940}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000010940, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000010940, ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000010940}; RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSACAP00000010940} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR STRING; 28377.ENSACAP00000010940; -. DR Ensembl; ENSACAT00000011168; ENSACAP00000010940; ENSACAG00000011070. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; L7MZX2; -. DR OMA; TCVEWLC; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000001646; Chromosome 2. DR Bgee; ENSACAG00000011070; Expressed in 4 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003982154. FT TRANSMEM 312 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 41243 MW; 7D62D9847F30BEE4 CRC64; MGLSQEDPFL LLFGVSALLL GGSSGSSSHS LRYVYTSVSE PGQQEPQFFS VGYVDEQEFV SYDSKAKRRF PAVPWIRKVE EEDPEYWEQG SQLVWSAEQV FRMDLENVAR YYNQSGGAHI LQYMYGCELR KDGSKGGYDQ LAYDGRDYIS FDKETLTYTA ADVPAQNTKR KWEAEPAIAQ RNKAYLEDIC IEWLQRYLDY GKETLLRTEK PEVKVTCKED YDGMETLICR VGGFYPKEID ITWTKDGEVW TQDVFHGLVS PNSDGTYYTW RSVTVDPKES ERYKCHVEHD GLPNPVDVAW EEPASASNLG LIIGWVLGIL LLIAVLAGIA VYFRNSQDGY RAAAGNDQGY SSSGAGKWDC WAHL // ID L7N049_CANLF Unreviewed; 299 AA. AC L7N049; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 12-SEP-2018, entry version 40. DE SubName: Full=MHC class I DLA-88 precursor {ECO:0000313|Ensembl:ENSCAFP00000000716}; GN Name=DLA88 {ECO:0000313|Ensembl:ENSCAFP00000000716}; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000000716, ECO:0000313|Proteomes:UP000002254}; RN [1] {ECO:0000313|Ensembl:ENSCAFP00000000716, ECO:0000313|Proteomes:UP000002254} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000000716, RC ECO:0000313|Proteomes:UP000002254}; RX PubMed=16341006; DOI=10.1038/nature04338; RG Broad Sequencing Platform; RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., RA Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., RA Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F., RA Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., RA Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., RA Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., RA Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., RA Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., RA Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., RA Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., RA Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., RA Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., RA Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., RA Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., RA Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., RA Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., RA Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., RA Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., RA Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., RA Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., RA Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., RA Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., RA Marabella R., Maru K., Matthews C., McDonough S., Mehta T., RA Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., RA Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., RA Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., RA Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., RA Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., RA Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., RA Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., RA Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., RA Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., RA Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., RA Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., RA Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., RA Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.; RT "Genome sequence, comparative analysis and haplotype structure of the RT domestic dog."; RL Nature 438:803-819(2005). RN [2] {ECO:0000313|Ensembl:ENSCAFP00000000716} RP IDENTIFICATION. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000000716}; RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAEX03008211; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSCAFT00000000775; ENSCAFP00000000716; ENSCAFG00000000487. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-CFA-1236974; ER-Phagosome pathway. DR Reactome; R-CFA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-CFA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-CFA-6798695; Neutrophil degranulation. DR Reactome; R-CFA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002254; Chromosome 12. DR Bgee; ENSCAFG00000000487; Expressed in 3 organ(s), highest expression level in liver. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002254}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000002254}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 299 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003982160. FT DOMAIN 210 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 299 AA; 33847 MW; 722EEC70BDB59AD8 CRC64; MEVVMPRALL VLLSAALAVT LTRAGSHSLR YFYTSVSRPG RGDPRFIAVG YVDDTQFVRF DSDAATGRME PRAPWVEQEG PEYWDGETRK VKETAQLYRV DLDTLRGYYN QSEAAGSHTI QTMYGCDLGP GGRLLRGYSQ DAYDGADYIA LNEDLRSWTA ADAAALITRR KREAAGDAGH LRNYLETTCV EWLRRYLEMG KETLLRAEPP STRVTRHPVS DREVTLRCWA LGFYPEEITL TWQRDGEDQT QDTEVVDTRP AGDGTFQKWA AVVVPSGQEQ RYTCHVQHEG LAEPVTRRW // ID L7N0X4_MYOLU Unreviewed; 370 AA. AC L7N0X4; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000000039}; GN Name=LOC102429481 {ECO:0000313|Ensembl:ENSMLUP00000000039}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000000039, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000000039, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000000039} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02056974; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000000039; -. DR Ensembl; ENSMLUT00000000040; ENSMLUP00000000039; ENSMLUG00000000040. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; L7N0X4; -. DR OMA; VTHHPVF; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 370 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003982176. FT TRANSMEM 314 337 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 218 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 370 AA; 41350 MW; D17DB63BE3F801D7 CRC64; RTPRMRVLSP PTLLLLLSGA LVLTPSWAGP HSMMYFYTIV SRPGRGEPRF LAVGYVDDTQ LVRFDSDSPN PRMEPRAPWM QQPWVEQEDP EYWEEQTLWA KGLTQTYRVN LQNLRGYYNQ SEDGSHTLQW MSGCDVGPDG RLLRGYSQYA YDGADYLALN EDLTSWTAAN MAAQISKRKL EQAGVAEHER RYLEGTCMPW LGLYLDKGKE TLQRADPPKA HVTHHPVSAH EVTLRCWALG FYPADISLTW QRDGEDQTQD MDLVETRPAG DGTFQKWAAV GVPPGEEQRY TCHVQHEGLP EPLILRWEPP SQTFIFIIMG ITVSLVLLGA VAGAVMWGRR RSDGSGGSYA QAASSDSGQG SDVSLSASKG // ID L7N0X6_MYOLU Unreviewed; 296 AA. AC L7N0X6; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 20-JUN-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000000091}; GN Name=LOC102418243 {ECO:0000313|Ensembl:ENSMLUP00000000091}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000000091, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000000091, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000000091} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02064590; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000000091; -. DR Ensembl; ENSMLUT00000000096; ENSMLUP00000000091; ENSMLUG00000000098. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; L7N0X6; -. DR OMA; GREDQCQ; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 239 263 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 139 225 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 296 AA; 33023 MW; CA9A18296DAF0650 CRC64; PRARWVEQVE PGYWDLSTRN AKATAQTFRG SLHNLRGYYN QSRDGSHTIQ WMQGCDMGPD GRLLRGYHQS AYDGTDYIAL NEDLSSWTAT STAAQITRRK WEEADEAERF RNILEGRCLE WLRRYLAMGK EALQRADPPK THVTHHPISD REVTLRCWAL GFYPADISLS WQRDGEEQTQ DTEFVETRPA GDGTFQKWVA LVVPPGEEQR YTCHVLHEGL PKPLTLRWEP PLWATIPPVG LVVGLVILGA VVTGAVVTGA VMWRRKRSGG KGGSYAQAAS SDGAQGSDVS LSASKG // ID L7N0Y8_MYOLU Unreviewed; 365 AA. AC L7N0Y8; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000000544}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000000544, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000000544} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The genome sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000000544} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02056977; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000000544; -. DR Ensembl; ENSMLUT00000000601; ENSMLUP00000000544; ENSMLUG00000000604. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; L7N0Y8; -. DR OMA; DEICAPW; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003982177. FT TRANSMEM 308 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 213 301 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 40465 MW; 3A0ECAFCAAB75992 CRC64; MRVMSPPTLL LLLSGALVLT PSWAGPHSLR YFLTAVSRPG RGEPRFLSVG YVDDTQFVRF DSDAPNPRME PRAPWMQQPW VERERPGYWD RETQISKSSA QAFQRSLETL RGYYNQSEDG SHTLQSTYGC DLGSEGRLIR GYEQHAYDGS DYIALNEDLL SWTAADKAAQ ITKRKWEAAG VAEMRSYLEG RCVESLLMYL DKGNETLQRA IPPKAHVTHH PVSAREVTLR CWALGFYPAD ISLTWQRDGE DQTQDMELVE TRPSGDGTFQ KWAAVVVPPG EEQRYTCHVQ HQGLPEPLTL RWAGARSLLP FIFIFMGIAG GLVLLGAVAG AVMWGRRCSA SGSGGSYTQA ASSDSAQGSD VSLLA // ID L7N0Z0_MYOLU Unreviewed; 295 AA. AC L7N0Z0; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000000662}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000000662, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000000662, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000000662} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02021973; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; L7N0Z0; -. DR Ensembl; ENSMLUT00000000727; ENSMLUP00000000662; ENSMLUG00000023145. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; L7N0Z0; -. DR OMA; LENECIE; -. DR OrthoDB; EOG091G1J60; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 240 259 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 140 228 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 295 AA; 33228 MW; 6E59F2443B33D647 CRC64; EPRAQGMEQE EPGYWNMSTG NAKRDAQIFR ESLHNLRGYY NQSEDGSHTY QWMYGCDMGP DGRLLRGYDQ FAYDGTDYIA LNEDLRSWTA ADTAAQITWR KWEEYGLAER YRNFLEGRCL ELLHRFLALG KEVLQRADPP KTHVTHHPIS DCEVTLRCWA LGFYPADISL SWQRDGEEQT QDMELVETRP AGDGTFQKWA ALVVPPGEEQ RYTCHVQHEG LPEPLTLRWE PPPWATFPPV GLVVGLVILG AVVTGAVMWR RKRSGGQGGS YAQAASNDSA PGSDVSLMAS NGESL // ID L7N126_MYOLU Unreviewed; 353 AA. AC L7N126; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 20-JUN-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000002042}; DE Flags: Fragment; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000002042, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000002042} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The genome sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000002042} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02056291; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAPE02056292; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000002042; -. DR Ensembl; ENSMLUT00000002243; ENSMLUP00000002042; ENSMLUG00000024844. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; L7N126; -. DR OMA; RKWEALG; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 353 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003982242. FT TRANSMEM 299 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 203 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMLUP00000002042}. SQ SEQUENCE 353 AA; 39532 MW; 398C42D116AF59B1 CRC64; LRPRTLLLLL SGALVLTPNW AGPHSLRYFH TIVSRPGRGE PHFLALGYVD DRQFVRFDSD ASPWMQQPWV EQERPGYWEE ETLRAKGTAQ LFRVNLQTAL GYYNQSEDGS HTLQWLYGCI LGPDGRLLQS YDQVAYDGAN YIALNEDLRS WRATDKAVQI TGRKWEEAGV AEEMRSYLEG LCVKWLLLYL EKGKETLQRA DPPKAHVTHH PISASEVTLR CWALGFYPSD ISLTWQRDGE DQTQDMELVE TRPAGDGTFQ KWAAVGVPPG EEQRYTCHVQ HEGLPEPLTL RWEPPSHTFV IIMGVTGGLI LLGAAAGAVI WGRRRSGWQG WGLSTLGSDS AQGSDVSLSA SKG // ID L7N132_MYOLU Unreviewed; 231 AA. AC L7N132; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 28-MAR-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000002184}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000002184, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000002184} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The genome sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000002184} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02055663; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; L7N132; -. DR Ensembl; ENSMLUT00000002403; ENSMLUP00000002184; ENSMLUG00000002407. DR GeneTree; ENSGT00900000141162; -. DR InParanoid; L7N132; -. DR OMA; WKGILER; -. DR OrthoDB; EOG0907079Q; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 231 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003982180. FT DOMAIN 26 208 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 231 AA; 26308 MW; 62F6B7F5F14D417B CRC64; MRVLRPPTLL LLLSGALVLT PSWAGLHSLR YFSTVLSGPG VGKSRYIAVG YVDDIEFVRF DNDAASPRLE PRIPWMQQPW VEQVYPDYWD QQTEIIKDWA QTHGGNLNNL RDYYNQSGNG SHTYQEMTGC VVGSDGRLLR GYSQYAYDGA DYLALNEDLT SWTAADMAAQ MTWRKLVYAP DPDYWKVALE SWCVHYLHVY LENGKKMLPR AGTRVRPPEQ GICRLGLASH E // ID L7N1C1_MYOLU Unreviewed; 366 AA. AC L7N1C1; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 20-JUN-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000006112}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000006112, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000006112, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000006112} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02055660; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000006112; -. DR Ensembl; ENSMLUT00000006694; ENSMLUP00000006112; ENSMLUG00000006693. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; L7N1C1; -. DR OMA; VHEIHER; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003982230. FT TRANSMEM 310 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 40942 MW; DC8A0E487527CD84 CRC64; MPAMRSPTLL LLLSGALVLT SSWAGPHSLR NFYTSVSRPG RGEPRYFEVG YVDDTQFVRF DSDALNPKVE PRAHWMQQPW VEQEDPGYWE EEALWVKVNE QVFRENLQIA LNYYNQSEDG SHTIQVMRGC DMGPNGRLLR GYSQWAYDGA DYIALNEDLT SWTAADMAAQ ITKRKWEAAG VAECVRSYLE GLCVKWLHIH LEKGKETLQR ADPPKAHVTH HPVSKHEVTL RCWALGFYPA DISLTWQHDG EDQTQDMELV ETRPAGDGTF QKWAAVGVPP GEEQRYTCHV QHEGLPEPLT LRWEPPPQTF IFIIMGIAGG LVLLGAVAAA VMWWRRRSGG KGGSYAQAAS SDSGQGSDVS LSASKG // ID L7N1H0_MYOLU Unreviewed; 366 AA. AC L7N1H0; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000008096}; GN Name=LOC102416963 {ECO:0000313|Ensembl:ENSMLUP00000008096}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000008096, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000008096, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000008096} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02060235; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000008096; -. DR Ensembl; ENSMLUT00000008884; ENSMLUP00000008096; ENSMLUG00000008888. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; L7N1H0; -. DR OMA; LENICVQ; -. DR OrthoDB; EOG091G0BBK; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003982429. FT TRANSMEM 309 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 41335 MW; 5BA7543D9192F06B CRC64; MLLTGSPALL LPLWGPLALA QTWAGPHSLR YFYTAVSRPY QLRPRFIILG YVDDTQFERF DSDSESQRVE PRAPWMELEE PGYWDRSRRN ARDSAQTFRR NLHTLSGYYN HSEEGSHTLQ LMLGCDMGPD GRLLRGYHQY AYDGTDYIAL NEDLRSWTAA STPAQITQRK WEETGEAEER RHYLQDDCLE LLIRFLEMGK EVLQRADPPK THVTHHPISD REVTLRCWAL GFYPADISLS WQRDGEEQTQ DMELVETRPA GDGTFQKWAA LVVPPGEEQR YTCHVQHEGL PEPLTLRWEP PLWATFPPVG LVVGLVILGA VVTGAVVTRA VMWRRKCSGG KGGSYAQAAS SDGAQGSDVS LSASEG // ID L7N1K7_MYOLU Unreviewed; 366 AA. AC L7N1K7; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000009864}; GN Name=LOC102440606 {ECO:0000313|Ensembl:ENSMLUP00000009864}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000009864, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000009864, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000009864} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02071518; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000009864; -. DR Ensembl; ENSMLUT00000010820; ENSMLUP00000009864; ENSMLUG00000028052. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; L7N1K7; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003982265. FT TRANSMEM 310 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 41015 MW; 55ACAE5FDB210325 CRC64; MRVLGPPSLL LLLPGALVLT PSWAGSHSMR YFYTAVSRPG RGEPRFLAVG YVDDSQFVRF DSDARDPRAE PRAPWMQQPW VEQERPGHWD RSTRIFKGAA QTFRRSLEIL RGYYNQSEDG SHTYQYMYGC DMGPDGRLLR GYYQYAYDGA DYIALNEDLT SWTTADMVAQ ITKRKWEADG VAEHYRSYLE GTCMPWLPIH LDKGKETLQR ADPPKAHVTH HPVSEHEVTL RCWALGFYPA DITLTWQRDG EDQTQDMELV ETRPAGDGSF QKWAAVGVPP GQEQRYTCHV QHEGLPEPLT LRWESPPQTF ILIIMGIAGG LVLLGAVAGA VMWGRRRSGG KEASYAQAAS SDSAQGSDVS LSASKG // ID L7N1M3_MYOLU Unreviewed; 366 AA. AC L7N1M3; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 20-JUN-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000010929}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010929, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000010929, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000010929} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02065645; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000010929; -. DR Ensembl; ENSMLUT00000011999; ENSMLUP00000010929; ENSMLUG00000028304. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00920000149921; -. DR InParanoid; L7N1M3; -. DR OMA; GINDRTE; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003982372. FT TRANSMEM 310 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 300 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 40914 MW; 59AE7DD2143E5B4E CRC64; MRVLRPPTLL LLLSGALVLT PSWAGPHSLR YFHTSVSRPG RGEPRFLAVG YVDDTQFVRF DSDAASPRAE PRAPWMQQPW VEQVYPGYWD RETQNFKAAA QIFRDGLQTL RGYYNQSEDG SHTYQCMVGC DLGPDGRLLR GYWQYAYDGA DYIALNEDLT SWTAADKAAQ ITKRKWEAEG WAERHRSYLE GLCVESLLLY LDKGKETLQR ADPPKAHVTH HGVSEREVTL RCWALGFYPA DIRLTWQRDG EDQTQDMELV ETRPAGDGTF QKWAAVGVPP GEEQRYTCHV EHEGLPKPLA LRWEPPSHTF IIIIMGIAGV LVLLGAVAAA VMWGRRRSGG RGGSYAQAAS SDSAQGSDVS LSASRS // ID L7N1M4_MYOLU Unreviewed; 236 AA. AC L7N1M4; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 20-JUN-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000010932}; DE Flags: Fragment; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010932, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000010932} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The genome sequence of Myotis lucifugus (Bat)."; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [3] {ECO:0000313|Ensembl:ENSMLUP00000010932} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02056292; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; L7N1M4; -. DR Ensembl; ENSMLUT00000012002; ENSMLUP00000010932; ENSMLUG00000012006. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; L7N1M4; -. DR OMA; ETRITRH; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 179 203 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 83 171 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMLUP00000010932}. SQ SEQUENCE 236 AA; 26186 MW; 9C56EAC30502431A CRC64; GSHTYQCLRG CHMRPYGRLL RGYIALNEDL TSWTDRAAQI TKHKWEAAGV VECVRSYLEG LCVKWLHIHL EKGKETLQRA DPPKAHVTHH PISAGEVTLR CWALGFYPAD ISLTWQRDGE DQTQDMELVE TRPSGDGTFQ KWAAVGVPPG QEQRYTCHVQ HKGLPEPLTL RWEPPSQTFI FIIMGIAGGL VLLGALAGAV MWWRRRSAGG SGRSYTQADS SYSGQGSDVS LSVSKG // ID L7N1R1_MYOLU Unreviewed; 366 AA. AC L7N1R1; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 20-JUN-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000013245}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000013245, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000013245, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000013245} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAPE02055657; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000013245; -. DR Ensembl; ENSMLUT00000014558; ENSMLUP00000013245; ENSMLUG00000024243. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; L7N1R1; -. DR OMA; EYFRAYV; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003982440. FT TRANSMEM 310 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 300 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 41083 MW; 7E926A2AD8D7AAA7 CRC64; MRVLSPPTLL LLLSGALVLT PSWAGPHSMR YFFTIVSRPG RGEPQFYIVG YVDDTQFVRF NSSAPNPRME PRARWMQQPW VEQEDPGYWE EQTLKAKDTA QLFRGNLQNL RGYYNQSEDG SHTLQVMFGC DIGPEGSLLR GYRQDAYDGV DYIALNEDLT SWTAADMAAQ ITKHKWEAEG WAERWRIYLE GLCVKSLLRY LDKGKETLQR ADPPKAHITH HPVSESEVTL RCWALGFYPA DISLTWQRDG EDQTQDMELV ETRPAGDGTF QKWAAVVVPP GEEQRYTCHV QHEGLPKSLT LRWEPPSHTF IIIMGIAGGL VVLVAVAGVV MWWRRRSAGG KGGSYAQAAS SDSGQGCDLS LSACKG // ID L7N260_MOUSE Unreviewed; 215 AA. AC L7N260; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 12-SEP-2018, entry version 37. DE SubName: Full=H-2 class I histocompatibility antigen, Q7 alpha chain {ECO:0000313|Ensembl:ENSMUSP00000112297}; GN Name=H2-Q7 {ECO:0000313|Ensembl:ENSMUSP00000112297, GN ECO:0000313|MGI:MGI:95936}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000112297, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000112297, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000112297, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000112297} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000112297}; RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR974466; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001185490.1; NM_001198561.1. DR UniGene; Mm.431282; -. DR ProteinModelPortal; L7N260; -. DR SMR; L7N260; -. DR MaxQB; L7N260; -. DR PeptideAtlas; L7N260; -. DR PRIDE; L7N260; -. DR Ensembl; ENSMUST00000116598; ENSMUSP00000112297; ENSMUSG00000060550. DR GeneID; 15018; -. DR UCSC; uc012ari.1; mouse. DR CTD; 15018; -. DR MGI; MGI:95936; H2-Q7. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000060550; Expressed in 24 organ(s), highest expression level in spleen. DR ExpressionAtlas; L7N260; baseline and differential. DR GO; GO:0071346; P:cellular response to interferon-gamma; IEA:Ensembl. DR GO; GO:0007566; P:embryo implantation; IEA:Ensembl. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 215 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003982391. FT DOMAIN 22 200 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 215 AA; 24376 MW; 6C3B1ED65C618965 CRC64; MALTMLLLLV AAALTLIETR AGQHSLQYFH TAVSRPGLGE PWFISVGYVD DTQFVRFDSD AENPRMEPRA RWMEQEGPEY WERETQIAKG HEQSFRGSLR TAQSYYNQSK GGSHTLQWMY GCDMGSDGRL LRGYLQFAYE GRDYIALNED LKTWTAVDMA AQITRRKWEQ AGIAEKDQAY LEGTCMQSLR RYLQLGKETL LRTGGQGGDC APAPA // ID L7N346_XENTR Unreviewed; 296 AA. AC L7N346; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 12-SEP-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000019884}; DE Flags: Fragment; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000019884, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000019884} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000019884} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099320; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; L7N346; -. DR STRING; 8364.ENSXETP00000019884; -. DR PaxDb; L7N346; -. DR Ensembl; ENSXETT00000019884; ENSXETP00000019884; ENSXETG00000033834. DR eggNOG; ENOG410ITUC; Eukaryota. DR eggNOG; ENOG4111EG6; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; L7N346; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000033834; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 269 291 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 172 257 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 131 151 {ECO:0000256|SAM:Coils}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSXETP00000019884}. SQ SEQUENCE 296 AA; 33762 MW; C74213CDE3D77E4C CRC64; ISSAAYPGLP QYSIIAYVDD VQYGRYNSDT RRCEPLIQSL MVFSEHLENQ TKLAQQTEIT QKAFMNLITD LLNKNYDNNI NYVFQTKAAC VLHEDGTVDV YKEVALDGKE LIVFDKERQE FVPATQEAVL LAQLLNKQAN AMEDKIFMEN ECTQHLTLYL PYIKNYLDKK VPRVKLSSSE SESGTKLHCR VYGFYPRDVE VKWIKNGRDE IHSEEAAQIL PNPDGTYQIR VSVGVTPEEG ATYSCHIDHS SLEKTLVVPF ETETKNSHIT YILIAVGVIV LFLAFGLGFF IQRKMK // ID L7N347_XENTR Unreviewed; 248 AA. AC L7N347; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 12-SEP-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000019892}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000019892, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000019892} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000019892} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099263; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01099264; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; L7N347; -. DR PaxDb; L7N347; -. DR Ensembl; ENSXETT00000019892; ENSXETP00000019892; ENSXETG00000009089. DR GeneTree; ENSGT00740000114936; -. DR OMA; GCEMNEN; -. DR OrthoDB; EOG091G1Z1T; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000009089; Expressed in 6 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}. FT DOMAIN 160 245 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 248 AA; 28676 MW; 3AEA9E02568222BE CRC64; MHMAYVDDLR YARYNNEFNR CEYWIPALST LYERMTMQKN YTHNFKISHN QKTKLLTHLY NKTSGKDAIH VYQTKSACEM HEDGTISAYQ EVAFDGKELI AYDYQMETFI PTTPEAQVVA QIWNEDYAKR EKIYLKNLCT YRFSKYLNAL ASDLEKLVPP KVKVSISESE SGAELHCRVY GFYPRDVEVK WIKNGRDEIH SEEAAQILPN PDGTYQIRVS VGVTPEGGAT YSCHVDHSSL EKALVVPF // ID L7N348_XENTR Unreviewed; 343 AA. AC L7N348; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 12-SEP-2018, entry version 35. DE SubName: Full=Uncharacterized LOC100036854 {ECO:0000313|Ensembl:ENSXETP00000019932}; GN Name=LOC100490896 {ECO:0000313|Ensembl:ENSXETP00000019932}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000019932, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000019932} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000019932}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000019932} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAMC01099306; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; L7N348; -. DR STRING; 8364.ENSXETP00000019932; -. DR PaxDb; L7N348; -. DR Ensembl; ENSXETT00000019932; ENSXETP00000019932; ENSXETG00000016466. DR Xenbase; XB-GENE-5894693; loc100036854. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; L7N348; -. DR OMA; DWARYDC; -. DR OrthoDB; EOG091G0K1X; -. DR Reactome; R-XTR-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000016466; Expressed in 10 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 343 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003982231. FT TRANSMEM 297 315 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 343 AA; 38927 MW; D1C39EECA1FD9198 CRC64; MACYISLVFL LGFPAVYSGS HSLHYYISML SAPAHEVPQY SIVVYADGLP IGRYNSDLHR AQFLIPSLNV LTEHLELQTK FAQRWQVYQE RKMAFLMGFL NRTSDRGTIH IYQRKFSCEL EEDGTIGGYQ EFALDGREVI TFDRENEVFV PATQEAVTML PRWNQYLGNA KGNKMYMENE CIEHIKLYLP LIMMDLEKKV KPKVKVSISE SDSGVELHCR VYGFYPRDVE VKWIKNGRDE IHSEEAAQIL PNPDGTYQIR VSVGVTPEGG ATYSCHIDHS SLEKALVVPF EGETKGYVIY IVIGVVVAAL LALCLQDSLT KRPFLIFLGF KGSRQSVSTD EQD // ID L8Y952_TUPCH Unreviewed; 214 AA. AC L8Y952; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=Saoe class I histocompatibility antigen, A alpha chain {ECO:0000313|EMBL:ELV12963.1}; GN ORFNames=TREES_T100008161 {ECO:0000313|EMBL:ELV12963.1}; OS Tupaia chinensis (Chinese tree shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia. OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV12963.1, ECO:0000313|Proteomes:UP000011518}; RN [1] {ECO:0000313|Proteomes:UP000011518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Zhang G., Fan Y., Yao Y., Huang Z.; RT "Genome of the Chinese tree shrew, a rising model animal genetically RT related to primates."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB363534; ELV12963.1; -; Genomic_DNA. DR ProteinModelPortal; L8Y952; -. DR InParanoid; L8Y952; -. DR Proteomes; UP000011518; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011518}; KW Reference proteome {ECO:0000313|Proteomes:UP000011518}. FT DOMAIN 1 174 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 214 AA; 24372 MW; F9C466ABEA71E008 CRC64; MRYFDTVVSR SGGEPRYIEV GYVDDTQFVR FDSDSASQRE EPRVPWMDKV DPEYWDRNTR RAKDNAQTYR LSLQTLLAYY NLSEAGSHTF QSMYGCEVGS DGRLLRGYRQ YAFNGRDYIA LNEDLRSWTA ADKVAQLTQR KWEAAGGAEL RRAYLEEECV QWLGIYLENG KETLQRAGTR GRGGSPAVLL GLLSHTEKKK VGFDVLGKVL TPTG // ID L8YAI9_TUPCH Unreviewed; 376 AA. AC L8YAI9; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 28-FEB-2018, entry version 27. DE SubName: Full=HLA class I histocompatibility antigen, A-23 alpha chain {ECO:0000313|EMBL:ELV11376.1}; GN ORFNames=TREES_T100005914 {ECO:0000313|EMBL:ELV11376.1}; OS Tupaia chinensis (Chinese tree shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia. OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV11376.1, ECO:0000313|Proteomes:UP000011518}; RN [1] {ECO:0000313|Proteomes:UP000011518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Zhang G., Fan Y., Yao Y., Huang Z.; RT "Genome of the Chinese tree shrew, a rising model animal genetically RT related to primates."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB365214; ELV11376.1; -; Genomic_DNA. DR ProteinModelPortal; L8YAI9; -. DR InParanoid; L8YAI9; -. DR Proteomes; UP000011518; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011518}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000011518}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 376 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003998909. FT TRANSMEM 297 320 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 376 AA; 41860 MW; F08CF24E6853441E CRC64; MVILAPRTVF LVLLGALALT ETWAGSHSMR YFEICVSRPG GDPRYLEVGY VDDTQIVRFD SDSVSQRMEP RAPWMDKVGP EYWEEETQRA QEYAQTDRRN FRILLGYYNQ SGAGSHTLQR MYGCNLGPDG RLLRGDQPKG YDGPXXXXXX XXXXAQITQR KSEAAGVAEG YKAYLEGRCV QWLGIYLENG KETLQRADPP KAHVTHHPTS DREATLRCWA LGFYPAEISL TWQRDGEDQT QDMELVETRP AGDGTFQKWA AVVVPSGEEQ RYTCHVQHEG LPEPLTLRWE PRPQSPLLIV GIVAGLVLLG VLVTGAIVIW RRSSGSDSAQ GSDVSLTAPK GETLQGWGGE GTVLGCGDLG WDVSSTRRPH QRFLLQ // ID L8YB72_TUPCH Unreviewed; 277 AA. AC L8YB72; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 25-OCT-2017, entry version 26. DE SubName: Full=Hereditary hemochromatosis protein like protein {ECO:0000313|EMBL:ELV13482.1}; GN ORFNames=TREES_T100008055 {ECO:0000313|EMBL:ELV13482.1}; OS Tupaia chinensis (Chinese tree shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia. OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV13482.1, ECO:0000313|Proteomes:UP000011518}; RN [1] {ECO:0000313|Proteomes:UP000011518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Zhang G., Fan Y., Yao Y., Huang Z.; RT "Genome of the Chinese tree shrew, a rising model animal genetically RT related to primates."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB361180; ELV13482.1; -; Genomic_DNA. DR ProteinModelPortal; L8YB72; -. DR InParanoid; L8YB72; -. DR Proteomes; UP000011518; Unassembled WGS sequence. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011518}; KW Reference proteome {ECO:0000313|Proteomes:UP000011518}. FT DOMAIN 203 240 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 277 AA; 31316 MW; AD6FB47A1048B5AB CRC64; MGWLPPCPPP LPPREGLALS PGSHSLRYLF MGASEPDLGL PLFEALGYVD DQLFVSYDHE SRRAEPRAPW VPSGTSSRQW LQLSQGLKGW DHMFTVDLWT IMDNQNHSKG SHTLQVILGC EVREDHSSRG FWRYGYDGQD HLDFRPETLD WRAAGPGARA TKLEWEVHKI RARENRDYLE RDCPEQLRWL LELGRGVLDR QAPPLVKVTR HVASAVTTLR CQALDFYPQD VSLKWLKDGQ PLDAQQALPE DVAPNGDGTY RGRVAVAVAP GVAFKKM // ID L8YEI6_TUPCH Unreviewed; 310 AA. AC L8YEI6; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 25-OCT-2017, entry version 20. DE SubName: Full=HLA class I histocompatibility antigen, B-40 alpha chain {ECO:0000313|EMBL:ELV13405.1}; GN ORFNames=TREES_T100011112 {ECO:0000313|EMBL:ELV13405.1}; OS Tupaia chinensis (Chinese tree shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia. OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV13405.1, ECO:0000313|Proteomes:UP000011518}; RN [1] {ECO:0000313|Proteomes:UP000011518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Zhang G., Fan Y., Yao Y., Huang Z.; RT "Genome of the Chinese tree shrew, a rising model animal genetically RT related to primates."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB361757; ELV13405.1; -; Genomic_DNA. DR ProteinModelPortal; L8YEI6; -. DR InParanoid; L8YEI6; -. DR Proteomes; UP000011518; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011518}; KW Reference proteome {ECO:0000313|Proteomes:UP000011518}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 310 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003999007. FT DOMAIN 240 310 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 310 AA; 35282 MW; FE233FC979C48550 CRC64; MAVMAFRILL LVLSGALALS ETWAASPSMR YFEVSVSRPG GEPRYIRVGY VDDTQFTRFD SDSASQREEP RAPWMDKVDP EYWDLNTRNA KDNAQTFRRS LQNLRSYYNQ SEASSHTLQS MYGCDIEPDG RLLHGYHQLA YDGLDYIALN EDLRSWTAVD TAAQITQRKW EASAWAKRFR AYLEGECMQW LGTHLQNGKE TLQRADGHTG LLPGQWEGLH HVRISLXXXX XXXXXXXXEA TLRCWALGFY PAEISLTWQR DGEDQTQDME LVETRPAGDG TFQKWAAVVV PSGEEQRYTC STRGCLSPSP // ID L9J9X7_TUPCH Unreviewed; 364 AA. AC L9J9X7; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 25-OCT-2017, entry version 28. DE SubName: Full=IgG receptor FcRn large subunit p51 {ECO:0000313|EMBL:ELW47138.1}; GN ORFNames=TREES_T100015212 {ECO:0000313|EMBL:ELW47138.1}; OS Tupaia chinensis (Chinese tree shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia. OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW47138.1, ECO:0000313|Proteomes:UP000011518}; RN [1] {ECO:0000313|Proteomes:UP000011518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Zhang G., Fan Y., Yao Y., Huang Z.; RT "Genome of the Chinese tree shrew, a rising model animal genetically RT related to primates."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB321143; ELW47138.1; -; Genomic_DNA. DR RefSeq; XP_006160203.1; XM_006160141.2. DR ProteinModelPortal; L9J9X7; -. DR GeneID; 102492772; -. DR KEGG; tup:102492772; -. DR CTD; 2217; -. DR InParanoid; L9J9X7; -. DR Proteomes; UP000011518; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011518}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:ELW47138.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000011518}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003998977. FT TRANSMEM 296 320 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 201 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 39337 MW; 232986630E4D7D05 CRC64; MRVPGPQPCA RRLLLLLPAA RGAASHLALL YHLTAVSAPA PGTPNFWASG WLGPQQYLSY SSLQGQAEPC GAWVWESQVS WYWEKETADL RNKQKLFLEA LKALKGKGPY VLQGLLGCEL GPDNASVPTA KFALNGEDFM TFDPRQGNWS GDWPEAGDIS SRWQAQAEAV SREKTFLLYS CPQRLLGHLE RGRGNLEGKE PPSMRLKARP GSPGFSVLTC SAFSFYPPEL QLRFLRNGLA AGSGEGDLGP NGDGSFHAWS SLVVKRGDEH HYRCLVRHAG LAQPLTVELE SPATSLVPVV AVVISLALLI AAAVGGALLW RRMRSGLPAP WIAFRGDDVG ALLPTPGLHQ DADSQDINAF PATV // ID L9KGN3_TUPCH Unreviewed; 329 AA. AC L9KGN3; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 22-NOV-2017, entry version 25. DE SubName: Full=H-2 class I histocompatibility antigen, D-D alpha chain {ECO:0000313|EMBL:ELW61838.1}; GN ORFNames=TREES_T100017812 {ECO:0000313|EMBL:ELW61838.1}; OS Tupaia chinensis (Chinese tree shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia. OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW61838.1, ECO:0000313|Proteomes:UP000011518}; RN [1] {ECO:0000313|Proteomes:UP000011518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Zhang G., Fan Y., Yao Y., Huang Z.; RT "Genome of the Chinese tree shrew, a rising model animal genetically RT related to primates."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB320852; ELW61838.1; -; Genomic_DNA. DR ProteinModelPortal; L9KGN3; -. DR Proteomes; UP000011518; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011518}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000011518}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 329 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003999812. FT DOMAIN 181 269 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 329 AA; 35700 MW; CFC343EEFE7A3B80 CRC64; MGLCTRACPP LFLLLLLGEA AAHPMTQPWS HSLRYDLTAI SQPSPGQPEV TALGYLDGRA FIAYDSRSDG AKHRGPGVTD PQLAPTLANR EAAFWEGHAR DLVWGLKTIE GYNELSGTQL QQELRRTEAL AGFLGGNVGC GLCTLTTLPP GIARRGGRGE QRWGSGPMCP CALSFWNRVP PRVVVTQQEE PEGNHSLRCR AFGFSPANIT LTWLPVGKEL TLDTGLRGTQ PAGDGTYQGW AAVQVAPGEE QRYTCLVEHP GLEGPLSVTW GRNDSLPTEE PAIKSKPRPL VEMGGWCHGN TMLRMLKPQV SPLVQGLLEV FLSTLGPYW // ID L9KL18_TUPCH Unreviewed; 344 AA. AC L9KL18; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 25-OCT-2017, entry version 23. DE SubName: Full=Patr class I histocompatibility antigen, A-126 alpha chain {ECO:0000313|EMBL:ELW61837.1}; GN ORFNames=TREES_T100017809 {ECO:0000313|EMBL:ELW61837.1}; OS Tupaia chinensis (Chinese tree shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia. OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW61837.1, ECO:0000313|Proteomes:UP000011518}; RN [1] {ECO:0000313|Proteomes:UP000011518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Zhang G., Fan Y., Yao Y., Huang Z.; RT "Genome of the Chinese tree shrew, a rising model animal genetically RT related to primates."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB320852; ELW61837.1; -; Genomic_DNA. DR ProteinModelPortal; L9KL18; -. DR InParanoid; L9KL18; -. DR Proteomes; UP000011518; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 2. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011518}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000011518}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 344 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003999926. FT TRANSMEM 293 318 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 344 AA; 37885 MW; A8261204D5848919 CRC64; MEVFAPRALL LALSGALVVA EVWAGSHSMM YIHTAVSRTG GEPRFVLAGY VDNTEFVRFD SDSASACGAT GAVDGQGGVG GGLGGRARPR PRVELNGVSG ADEAGIHTVQ WMYGCDVAPD GRFLRGYMQS AYDGAEFIAL NEDLRSWTAA DLVAQLSKFK WEAGDVTEQY RAYLEGECVE WLRRLLENGK DTLLRADPPK AHVTHHPTSD REATLRCWAL GFYPAEISLT WQRDGEDQTQ DMELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSWSTVVIAS TVLLGVLVIG AVVFVTIWRK KNSGPRDRRL EVPPRPNPVY TSWH // ID L9KUK1_TUPCH Unreviewed; 150 AA. AC L9KUK1; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 20-DEC-2017, entry version 15. DE SubName: Full=Zinc-alpha-2-glycoprotein {ECO:0000313|EMBL:ELW64867.1}; GN ORFNames=TREES_T100020570 {ECO:0000313|EMBL:ELW64867.1}; OS Tupaia chinensis (Chinese tree shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia. OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW64867.1, ECO:0000313|Proteomes:UP000011518}; RN [1] {ECO:0000313|Proteomes:UP000011518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Zhang G., Fan Y., Yao Y., Huang Z.; RT "Genome of the Chinese tree shrew, a rising model animal genetically RT related to primates."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB320709; ELW64867.1; -; Genomic_DNA. DR ProteinModelPortal; L9KUK1; -. DR Proteomes; UP000011518; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000011518}; KW Reference proteome {ECO:0000313|Proteomes:UP000011518}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 150 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004000211. FT DOMAIN 25 108 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 112 132 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 150 AA; 17660 MW; 012A44B6265F55CC CRC64; MPFLLALLCL LSPAASQESK NRVDSLRYYY AGKSEFSEVF PRLQGTGYIN DRPFFYYDST NHKAEPLKPW CEAEGMVNWE KETQFQKERE NLFMETLGDI LDYYNDNNDP AAQNTQEKWN EYANNAKKYL EEECPDTLRK YLSYNPSSLD // ID L9KVX2_TUPCH Unreviewed; 639 AA. AC L9KVX2; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 28-FEB-2018, entry version 27. DE SubName: Full=Guanine nucleotide-binding protein subunit beta-2-like 1 {ECO:0000313|EMBL:ELW66848.1}; GN ORFNames=TREES_T100007569 {ECO:0000313|EMBL:ELW66848.1}; OS Tupaia chinensis (Chinese tree shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia. OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW66848.1, ECO:0000313|Proteomes:UP000011518}; RN [1] {ECO:0000313|Proteomes:UP000011518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Zhang G., Fan Y., Yao Y., Huang Z.; RT "Genome of the Chinese tree shrew, a rising model animal genetically RT related to primates."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB320636; ELW66848.1; -; Genomic_DNA. DR ProteinModelPortal; L9KVX2; -. DR InParanoid; L9KVX2; -. DR Proteomes; UP000011518; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.130.10.10; -; 2. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR020472; G-protein_beta_WD-40_rep. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR InterPro; IPR001680; WD40_repeat. DR InterPro; IPR019775; WD40_repeat_CS. DR InterPro; IPR017986; WD40_repeat_dom. DR InterPro; IPR036322; WD40_repeat_dom_sf. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF00400; WD40; 7. DR PRINTS; PR00320; GPROTEINBRPT. DR SMART; SM00320; WD40; 7. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF50978; SSF50978; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00678; WD_REPEATS_1; 3. DR PROSITE; PS50082; WD_REPEATS_2; 5. DR PROSITE; PS50294; WD_REPEATS_REGION; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011518}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000011518}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}. FT TRANSMEM 267 288 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 247 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 334 639 WD_REPEATS_REGION. FT {ECO:0000259|PROSITE:PS50294}. FT REPEAT 334 366 WD. {ECO:0000256|PROSITE- FT ProRule:PRU00221}. FT REPEAT 377 420 WD. {ECO:0000256|PROSITE- FT ProRule:PRU00221}. FT REPEAT 421 462 WD. {ECO:0000256|PROSITE- FT ProRule:PRU00221}. FT REPEAT 520 544 WD. {ECO:0000256|PROSITE- FT ProRule:PRU00221}. FT REPEAT 609 639 WD. {ECO:0000256|PROSITE- FT ProRule:PRU00221}. SQ SEQUENCE 639 AA; 70438 MW; 1FFC9086DAC139E5 CRC64; MCTHPQSTQR ARHHPQQSPA GVLGSGSLNH WATGWLPARH LKPPVTILLR TYSAQVSPLH PITNPHTQAL QTSLCGPLLV PAGTHSLHYH YLALSEPGAG LPRFLAVGYV DDQPFIRYDS RTGRAEPQAP WMASVDTQYW ETETQKQRGW EKVQQVEMWT VMAYHNHSGA SLRVCYAEYD KAYLQGLCLA SLRRYLELGG RSLARTEPPT VQVTKHQAPD GEVTLKCWAL GFYPRAISLS WWLGGQELAL ETEHVETRPK SPSGHGALAG AVAAVLAAVL LVAGAVMLKK HLPARAEKAY EQAPGDWRDP GDWEWGVGPQ GTAGRPRGTT TRRFVGHTKD VLSVAFSSDN RQIVSGSRDK TIKLWNTLGV CKYTVQDESH SEWVSCVRFS PNSSNPIIVS CGWDKLVKVW NLANCKLKTN HIGHTGYLNT VTVSPDGSLC ASGGKDGQAM LWDLNEGKHL YTLDGGDIIN ALCFSPNRYW LCAATGPSIK IWDLEGKIIV DELKQEVIST SSKAEPPQCT SLAWSADGQT LFAGYTDNLV RVWQCVWGIY RKYGGDIINA LCFSPNRYWL CAATGPSIKI WDLEGKIIVD ELKQEVISTS SKAEPPQCTS LAWSADGQTL FAGYTDNLVR VWQVTIGTR // ID L9KYQ2_TUPCH Unreviewed; 514 AA. AC L9KYQ2; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 28-FEB-2018, entry version 24. DE SubName: Full=MHC class I polypeptide-related sequence B {ECO:0000313|EMBL:ELW67838.1}; GN ORFNames=TREES_T100003950 {ECO:0000313|EMBL:ELW67838.1}; OS Tupaia chinensis (Chinese tree shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia. OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW67838.1, ECO:0000313|Proteomes:UP000011518}; RN [1] {ECO:0000313|Proteomes:UP000011518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Zhang G., Fan Y., Yao Y., Huang Z.; RT "Genome of the Chinese tree shrew, a rising model animal genetically RT related to primates."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB320598; ELW67838.1; -; Genomic_DNA. DR ProteinModelPortal; L9KYQ2; -. DR InParanoid; L9KYQ2; -. DR Proteomes; UP000011518; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR Gene3D; 3.40.250.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR036873; Rhodanese-like_dom_sf. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 2. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011518}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000011518}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 433 456 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 329 423 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 514 AA; 56294 MW; 3C641CB2DD5FDB37 CRC64; MQVVQGSSPL GLVVLGMEEP AACSSRGGCS PRDGAFCKYA LTSCNSIKTA IEKRSEKEST RLDPQRMRRA DPRERVAEVL RAQRAGQFLQ LLGASWDLPK LDGDAHPKFE ERHIHIPGAS FDIDQCSVPK SSYDHVLPRS AHLPEYRPPG VFASRMWCPG TPAAPAGPHT LQYTLTVGSQ DGSVQPRFLA EGHLDSQPFL HYDSENGRAE PRGPWAEAVL GAETRDAENE LLTDKGKDLR MSLAVAAGAQ RSTRGFRDFR YDGEPLLSYD PKTQRWTVPW PSAQALAASL QRSWEDGAAE ARKHYRYTLA DCVGELKRYL RSRMGFQRPA VTVTHSEPSG GTVNLTCWAF GFYPWNISLA WHQDGQPLSQ DAQWSGGVLP YENGTYQAWV VTRVPQGEEP QFTCHVGHGG NHSTHPVPGK AVDLQSGRSH ATIGAAVAVA VAVFSGAVAV VLYFCWCRRK HGAPETHPCP GEHSELMSVH IQDPQQTVNT GPEGTGQPGV RSLLQPLEPQ AEDE // ID L9L8C3_TUPCH Unreviewed; 345 AA. AC L9L8C3; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 22-NOV-2017, entry version 26. DE SubName: Full=Hereditary hemochromatosis protein like protein {ECO:0000313|EMBL:ELW71138.1}; GN ORFNames=TREES_T100011421 {ECO:0000313|EMBL:ELW71138.1}; OS Tupaia chinensis (Chinese tree shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia. OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW71138.1, ECO:0000313|Proteomes:UP000011518}; RN [1] {ECO:0000313|Proteomes:UP000011518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Zhang G., Fan Y., Yao Y., Huang Z.; RT "Genome of the Chinese tree shrew, a rising model animal genetically RT related to primates."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB320473; ELW71138.1; -; Genomic_DNA. DR ProteinModelPortal; L9L8C3; -. DR InParanoid; L9L8C3; -. DR Proteomes; UP000011518; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011518}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000011518}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT DOMAIN 233 322 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 345 AA; 38331 MW; 3E5752B368F77800 CRC64; MVTRCGKDGF PIRVPHPFHV VHINKVSSRA GVTGSRQEPT RQPPTNHLAS EGTHTLRYDL MALPPDWPRR PQFLALGYVD DEPFLRYDSE GHRAEPWGPR MSRYPGAESW ARETEDLKEK EQQLRGTLAA IMSQQGQDRG FHSLQATLGC ELQDNLSTGG FWRLGYNGQD FLTFDLETLT WTATLPSAQR IKKFWERHSP QADLVKVYLQ ETCPAQLRRH LASLRGLGSA DSPLVNVIRR QNPLGRVTLT CQAFNSYPRG ATLTWLRDGE PVPQGTVGLE AILPSGDGTY QTWLTTQTQP GEEERFTCHV GHGGLNTTVP VVLGKEPESS GLSELEVGSG GAPWA // ID L9LCI9_TUPCH Unreviewed; 253 AA. AC L9LCI9; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 25-OCT-2017, entry version 17. DE SubName: Full=NKG2D ligand 4 {ECO:0000313|EMBL:ELW72775.1}; GN ORFNames=TREES_T100017495 {ECO:0000313|EMBL:ELW72775.1}; OS Tupaia chinensis (Chinese tree shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia. OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW72775.1, ECO:0000313|Proteomes:UP000011518}; RN [1] {ECO:0000313|Proteomes:UP000011518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Zhang G., Fan Y., Yao Y., Huang Z.; RT "Genome of the Chinese tree shrew, a rising model animal genetically RT related to primates."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB320391; ELW72775.1; -; Genomic_DNA. DR ProteinModelPortal; L9LCI9; -. DR InParanoid; L9LCI9; -. DR Proteomes; UP000011518; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011518}; KW Reference proteome {ECO:0000313|Proteomes:UP000011518}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 253 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004000223. FT DOMAIN 49 212 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 253 AA; 28423 MW; 4BFCA25F148B6F26 CRC64; MGSARLPLAL VMVYLSSLLL LTEARMTLGC EFPERPAEEG DAHCLCLDFT IQSQSLPGQP WCAVQGSVDR KTFLQYDSDS DKARPVGVLG EEVNTTRAWT ELTQMLGEIG RELRSLLSGI TLEKKEHEVP PSLQAELLCR REAEQCAGAS WQFNINGRTA LLLDAMSMNW TILSPGARGI KEEWESDRGL AEYFRKISVG DCNHWLREFL ELWETMLEPT ATLQPAQMSL NEAVTKFPRQ NEVQPIMPSS TEF // ID L9LCJ4_TUPCH Unreviewed; 210 AA. AC L9LCJ4; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 20-DEC-2017, entry version 16. DE SubName: Full=NKG2D ligand 2 {ECO:0000313|EMBL:ELW72780.1}; DE Flags: Fragment; GN ORFNames=TREES_T100017528 {ECO:0000313|EMBL:ELW72780.1}; OS Tupaia chinensis (Chinese tree shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia. OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW72780.1, ECO:0000313|Proteomes:UP000011518}; RN [1] {ECO:0000313|Proteomes:UP000011518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Zhang G., Fan Y., Yao Y., Huang Z.; RT "Genome of the Chinese tree shrew, a rising model animal genetically RT related to primates."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB320391; ELW72780.1; -; Genomic_DNA. DR ProteinModelPortal; L9LCJ4; -. DR InParanoid; L9LCJ4; -. DR Proteomes; UP000011518; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000011518}; KW Reference proteome {ECO:0000313|Proteomes:UP000011518}. FT DOMAIN 12 170 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 59 79 {ECO:0000256|SAM:Coils}. FT NON_TER 1 1 {ECO:0000313|EMBL:ELW72780.1}. SQ SEQUENCE 210 AA; 23823 MW; 55F4DBCCD06F7B31 CRC64; HALSYDFTII GEGGHRWCEV QGQVDRKVFL SYDCGNDKVN LISDLGKKVD NISAWNVQMT TLKDAGEQLQ KKLRDIKLEN YGIKGSLPLQ ARMSCECDAS GHTSGAWHFG FDGQTFLLFD PEKDMWTVVH DAVNEMKEQW ENDREMAMFL EKVSLGDCGS WLEEFLKCWE EVLEPTASPT MAPDTANGAR PWSFPVILTI SVLLCISWFF // ID L9LCV1_TUPCH Unreviewed; 689 AA. AC L9LCV1; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 25-OCT-2017, entry version 14. DE SubName: Full=NKG2D ligand 4 {ECO:0000313|EMBL:ELW72781.1}; GN ORFNames=TREES_T100017529 {ECO:0000313|EMBL:ELW72781.1}; OS Tupaia chinensis (Chinese tree shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia. OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW72781.1, ECO:0000313|Proteomes:UP000011518}; RN [1] {ECO:0000313|Proteomes:UP000011518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Zhang G., Fan Y., Yao Y., Huang Z.; RT "Genome of the Chinese tree shrew, a rising model animal genetically RT related to primates."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB320391; ELW72781.1; -; Genomic_DNA. DR ProteinModelPortal; L9LCV1; -. DR InParanoid; L9LCV1; -. DR Proteomes; UP000011518; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 3. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 3. DR SUPFAM; SSF54452; SSF54452; 3. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011518}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000011518}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 411 429 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 647 671 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 3 153 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 161 329 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 450 619 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 689 AA; 77043 MW; E34BEF8F19956626 CRC64; MQGSVDREKF LQYDSDSDKA RPVGVLEEEV NTTRAWTELT QTLGEVGREL RILLILSGVT LEEKEPEGPP SLQAELLCRR EAEQCAGASW QFSINGRTAL LLDAMSMTWT ILSPGARGNK EEWESDRGLA EYLRKISVGD CNHWLRAVLE LWETTLEPTD THALCYDFTL IPSPRPGQGW CEVQGQVDWK VFLSYDCGSK VKPISPLGKK VNGTRAWEDQ VIMLRDAGEI FKERLPDIKL EDDGNRGSLP LQARMSCKCD ASGHTTGAWQ FSFDGQTFLL FDPEKRMWTA VHHTAGGMKE QWENDREMAM FLEKVSLGDG GSWLEEFLKC WEEVLEPTDT LAVRPGELER VSLRGDTLGK LSPEFWQILT VTDQGEDRAY PGVGLLTLKR MQVTMWMPTA ATQLLSTMES ASLPLALVIV YLSSLLLLTE ARMTLGCEFP ERPAEEGDVH SLCLNFTVQS QSRPEQPWCA VQGSVDREKF LQYDSDSDKA RPVGVLGEEV NTTRAWTELT QTLGEVGREL RSLLSGITLE KKEPEGPLRL QAELLCRREA EQCAGASWQF SINGRTALLL DAMSMTWTIL SPGARGIKEE WESDRGLAEY FRKISVGDCN HWLREFLELW ETMLEPTVPP SKTPYTNQSS STTLNAYVVP ITIPCIVIVI IIIIITCSLA FGCSPGGVTE GEEQAGPLL // ID L9LCX3_TUPCH Unreviewed; 235 AA. AC L9LCX3; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 25-OCT-2017, entry version 16. DE SubName: Full=NKG2D ligand 1 {ECO:0000313|EMBL:ELW72778.1}; GN ORFNames=TREES_T100017493 {ECO:0000313|EMBL:ELW72778.1}; OS Tupaia chinensis (Chinese tree shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia. OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW72778.1, ECO:0000313|Proteomes:UP000011518}; RN [1] {ECO:0000313|Proteomes:UP000011518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Zhang G., Fan Y., Yao Y., Huang Z.; RT "Genome of the Chinese tree shrew, a rising model animal genetically RT related to primates."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB320391; ELW72778.1; -; Genomic_DNA. DR ProteinModelPortal; L9LCX3; -. DR InParanoid; L9LCX3; -. DR Proteomes; UP000011518; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011518}; KW Reference proteome {ECO:0000313|Proteomes:UP000011518}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 235 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004000196. FT DOMAIN 21 190 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 235 AA; 26999 MW; 78FE24FCED060453 CRC64; MLSLLGLLCL LHGIWAAPGD LHSLCYDFTV IFKPVIQQWS CEVQGKVDEK SFLYYNCDIK EVKPSGLLGK EIQRTNTWEE QNEMLMDVID VFKQQLPEVE PKNYTIRGPL TLQGRMSCQC EANGLSNGSW RFSFNGQIFL LFDSKKRKWT VVHSGARLME KTWVNDRDVT EFFRKISVGD CRRWLENFLV HWDKMLETTG PPTVVPNAFH AKATTIGPRL WTLLVILTIS VLLGT // ID M0QYM4_HUMAN Unreviewed; 167 AA. AC M0QYM4; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 12-SEP-2018, entry version 33. DE SubName: Full=IgG receptor FcRn large subunit p51 {ECO:0000313|Ensembl:ENSP00000469933}; DE Flags: Fragment; GN Name=FCGRT {ECO:0000313|Ensembl:ENSP00000469933}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000469933, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000469933, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000469933} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2013) to UniProtKB. RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC010619; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; M0QYM4; -. DR PRIDE; M0QYM4; -. DR Ensembl; ENST00000600273; ENSP00000469933; ENSG00000104870. DR UCSC; uc061bew.1; human. DR EuPathDB; HostDB:ENSG00000104870.12; -. DR HGNC; HGNC:3621; FCGRT. DR OpenTargets; ENSG00000104870; -. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR ChiTaRS; FCGRT; human. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000104870; Expressed in 208 organ(s), highest expression level in mucosa of transverse colon. DR ExpressionAtlas; M0QYM4; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:M0QYM4, KW ECO:0000213|PeptideAtlas:M0QYM4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 167 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004004257. FT DOMAIN 27 167 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 167 167 {ECO:0000313|Ensembl:ENSP00000469933}. SQ SEQUENCE 167 AA; 18540 MW; 044D315CE36EB4C4 CRC64; MGVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLS YNSLRGEAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE AFKALGGKGP YTLQGLLGCE LGPDNTSVPT AKFALNGEEF MNFDLKQGTW GGDWPEALAI SQRWQQQ // ID M0QYN1_HUMAN Unreviewed; 211 AA. AC M0QYN1; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 12-SEP-2018, entry version 37. DE SubName: Full=IgG receptor FcRn large subunit p51 {ECO:0000313|Ensembl:ENSP00000472604}; DE Flags: Fragment; GN Name=FCGRT {ECO:0000313|Ensembl:ENSP00000472604}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000472604, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000472604, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000472604} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2013) to UniProtKB. RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC010619; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M0QYN1; -. DR SMR; M0QYN1; -. DR PeptideAtlas; M0QYN1; -. DR PRIDE; M0QYN1; -. DR Ensembl; ENST00000598319; ENSP00000472604; ENSG00000104870. DR UCSC; uc061bfd.1; human. DR EuPathDB; HostDB:ENSG00000104870.12; -. DR HGNC; HGNC:3621; FCGRT. DR OpenTargets; ENSG00000104870; -. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR ChiTaRS; FCGRT; human. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000104870; Expressed in 208 organ(s), highest expression level in mucosa of transverse colon. DR ExpressionAtlas; M0QYN1; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:M0QYN1, KW ECO:0000213|PeptideAtlas:M0QYN1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 211 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004005293. FT DOMAIN 26 196 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000472604}. SQ SEQUENCE 211 AA; 23800 MW; DCA5408ADE509C7F CRC64; GVPRPQPWAL GLLLFLLPGS LGAESHLSLL YHLTAVSSPA PGTPAFWVSG WLGPQQYLSY NSLRGEAEPC GAWVWENQVS WYWEKETTDL RIKEKLFLEA FKALGGKGPY TLQGLLGCEL GPDNTSVPTA KFALNGEEFM NFDLKQGTWG GDWPEALAIS QRWQQQDKAA NKELTFLLFS CPHRLREHLE RGRGNLEWKE PKARQIFCAW I // ID M0QYN9_HUMAN Unreviewed; 225 AA. AC M0QYN9; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 12-SEP-2018, entry version 35. DE SubName: Full=IgG receptor FcRn large subunit p51 {ECO:0000313|Ensembl:ENSP00000469968}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSP00000469968}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000469968, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000469968, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000469968} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2013) to UniProtKB. RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC010619; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M0QYN9; -. DR SMR; M0QYN9; -. DR PeptideAtlas; M0QYN9; -. DR PRIDE; M0QYN9; -. DR Ensembl; ENST00000598927; ENSP00000469968; ENSG00000104870. DR UCSC; uc061beu.1; human. DR EuPathDB; HostDB:ENSG00000104870.12; -. DR HGNC; HGNC:3621; FCGRT. DR OpenTargets; ENSG00000104870; -. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR ChiTaRS; FCGRT; human. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000104870; Expressed in 208 organ(s), highest expression level in mucosa of transverse colon. DR ExpressionAtlas; M0QYN9; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:M0QYN9, KW ECO:0000213|PeptideAtlas:M0QYN9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 225 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004004259. FT DOMAIN 27 197 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 225 AA; 24986 MW; 38B8B9C8489027F4 CRC64; MGVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLS YNSLRGEAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE AFKALGGKGP YTLQGLLGCE LGPDNTSVPT AKFALNGEEF MNFDLKQGTW GGDWPEALAI SQRWQQQDKA ANKELTFLLF SCPHRLREHL ERGRGNLEWK DTVSHYVAQA GLELLGSSDS PALVS // ID M0R0A9_HUMAN Unreviewed; 273 AA. AC M0R0A9; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 12-SEP-2018, entry version 47. DE SubName: Full=IgG receptor FcRn large subunit p51 {ECO:0000313|Ensembl:ENSP00000471118}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSP00000471118}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000471118, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000471118, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000471118} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2013) to UniProtKB. RN [4] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [5] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC010619; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_011524929.1; XM_011526627.2. DR ProteinModelPortal; M0R0A9; -. DR PeptideAtlas; M0R0A9; -. DR PRIDE; M0R0A9; -. DR Ensembl; ENST00000596975; ENSP00000471118; ENSG00000104870. DR UCSC; uc061bez.1; human. DR EuPathDB; HostDB:ENSG00000104870.12; -. DR HGNC; HGNC:3621; FCGRT. DR OpenTargets; ENSG00000104870; -. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR ChiTaRS; FCGRT; human. DR GenomeRNAi; 2217; -. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000104870; Expressed in 208 organ(s), highest expression level in mucosa of transverse colon. DR ExpressionAtlas; M0R0A9; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:M0R0A9, KW ECO:0000213|PeptideAtlas:M0R0A9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 273 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004005325. FT TRANSMEM 206 229 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 110 197 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 273 AA; 29301 MW; 990CC8EAED227B35 CRC64; MGVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLS YNSLRGEAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE AFKALGGKEP PSMRLKARPS SPGFSVLTCS AFSFYPPELQ LRFLRNGLAA GTGQGDFGPN SDGSFHASSS LTVKSGDEHH YCCIVQHAGL AQPLRVELES PAKSSVLVVG IVIGVLLLTA AAVGGALLWR RMRSGLPAPW ISLRGDDTGV LLPTPGEAQD ADLKDVNVIP ATA // ID M0R0H0_HUMAN Unreviewed; 153 AA. AC M0R0H0; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 12-SEP-2018, entry version 33. DE SubName: Full=IgG receptor FcRn large subunit p51 {ECO:0000313|Ensembl:ENSP00000471232}; DE Flags: Fragment; GN Name=FCGRT {ECO:0000313|Ensembl:ENSP00000471232}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000471232, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000471232, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000471232} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2013) to UniProtKB. RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC010619; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M0R0H0; -. DR PeptideAtlas; M0R0H0; -. DR PRIDE; M0R0H0; -. DR Ensembl; ENST00000598076; ENSP00000471232; ENSG00000104870. DR UCSC; uc061bff.1; human. DR EuPathDB; HostDB:ENSG00000104870.12; -. DR HGNC; HGNC:3621; FCGRT. DR OpenTargets; ENSG00000104870; -. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR ChiTaRS; FCGRT; human. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000104870; Expressed in 208 organ(s), highest expression level in mucosa of transverse colon. DR ExpressionAtlas; M0R0H0; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:M0R0H0, KW ECO:0000213|PeptideAtlas:M0R0H0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 1 114 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000471232}. SQ SEQUENCE 153 AA; 17093 MW; 24A45F523A2E43ED CRC64; WEKETTDLRI KEKLFLEAFK ALGGKGPYTL QGLLGCELGP DNTSVPTAKF ALNGEEFMNF DLKQGTWGGD WPEALAISQR WQQQDKAANK ELTFLLFSCP HRLREHLERG RGNLEWKAPW ISLRGDDTGV LLPTPGEAQD ADLKDVNVIP ATA // ID M0R220_HUMAN Unreviewed; 189 AA. AC M0R220; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 12-SEP-2018, entry version 33. DE SubName: Full=IgG receptor FcRn large subunit p51 {ECO:0000313|Ensembl:ENSP00000472256}; DE Flags: Fragment; GN Name=FCGRT {ECO:0000313|Ensembl:ENSP00000472256}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000472256, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000472256, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000472256} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2013) to UniProtKB. RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC010619; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M0R220; -. DR PeptideAtlas; M0R220; -. DR PRIDE; M0R220; -. DR Ensembl; ENST00000593381; ENSP00000472256; ENSG00000104870. DR UCSC; uc061bfe.1; human. DR EuPathDB; HostDB:ENSG00000104870.12; -. DR HGNC; HGNC:3621; FCGRT. DR OpenTargets; ENSG00000104870; -. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR ChiTaRS; FCGRT; human. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000104870; Expressed in 208 organ(s), highest expression level in mucosa of transverse colon. DR ExpressionAtlas; M0R220; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:M0R220, KW ECO:0000213|PeptideAtlas:M0R220}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 2 161 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000472256}. FT NON_TER 189 189 {ECO:0000313|Ensembl:ENSP00000472256}. SQ SEQUENCE 189 AA; 21194 MW; 272D05A6250A2AB4 CRC64; XSSPAPGTPA FWVSGWLGPQ QYLSYNSLRG EAEPCGAWVW ENQVSWYWEK ETTDLRIKEK LFLEAFKALG GKGPYTLQGL LGCELGPDNT SVPTAKFALN GEEFMNFDLK QGTWGGDWPE ALAISQRWQQ QDKAANKELT FLLFSCPHRL REHLERGRGN LEWKAPSPST LRSCNFGSCG MGWPLAPAR // ID M0R266_HUMAN Unreviewed; 141 AA. AC M0R266; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 12-SEP-2018, entry version 36. DE SubName: Full=IgG receptor FcRn large subunit p51 {ECO:0000313|Ensembl:ENSP00000472350}; DE Flags: Fragment; GN Name=FCGRT {ECO:0000313|Ensembl:ENSP00000472350}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000472350, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000472350, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000472350} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2013) to UniProtKB. RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC010619; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; M0R266; -. DR PRIDE; M0R266; -. DR Ensembl; ENST00000598491; ENSP00000472350; ENSG00000104870. DR UCSC; uc061bes.1; human. DR EuPathDB; HostDB:ENSG00000104870.12; -. DR HGNC; HGNC:3621; FCGRT. DR OpenTargets; ENSG00000104870; -. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR ChiTaRS; FCGRT; human. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000104870; Expressed in 208 organ(s), highest expression level in mucosa of transverse colon. DR ExpressionAtlas; M0R266; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|PeptideAtlas:M0R266}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 141 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004004306. FT DOMAIN 27 141 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 141 141 {ECO:0000313|Ensembl:ENSP00000472350}. SQ SEQUENCE 141 AA; 15498 MW; E9C47BBC61772EF2 CRC64; MGVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLS YNSLRGEAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE AFKALGGKGP YTLQGLLGCE LGPDNTSVPT AKFALNGEEF M // ID M0R4E9_RAT Unreviewed; 199 AA. AC M0R4E9; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 2. DT 12-SEP-2018, entry version 40. DE SubName: Full=RT1 class I, locus CE3 {ECO:0000313|Ensembl:ENSRNOP00000064233}; DE Flags: Fragment; GN Name=RT1-CE3 {ECO:0000313|Ensembl:ENSRNOP00000064233, GN ECO:0000313|RGD:1598231}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000064233, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000064233, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000064233, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000064233} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000064233}; RG Ensembl; RL Submitted (FEB-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044408; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; M0R4E9; -. DR Ensembl; ENSRNOT00000071840; ENSRNOP00000064233; ENSRNOG00000031607. DR RGD; 1598231; RT1-CE3. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; M0R4E9; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000031607; Expressed in 9 organ(s), highest expression level in liver. DR ExpressionAtlas; M0R4E9; baseline and differential. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}. FT DOMAIN 110 198 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSRNOP00000064233}. FT NON_TER 199 199 {ECO:0000313|Ensembl:ENSRNOP00000064233}. SQ SEQUENCE 199 AA; 22736 MW; 8E63D4729DEB127F CRC64; XNLRTALRYY NQSEGGSHTF QRMYGCDVGS DGSLLRGYNQ FAYDSLDYIA LNEDLKTWTA ADTTGRMTQS KWVQAGVADY YRAYLEGECV EWLRRYLELG KETLMRSDPP KAHVTLHPRP EGDVTLRCWA LGFYPADITL TWQLNGEDLT QDMELVETRP AGDGTFQKWA SVVVPPGKEQ NYTCLVEHEG LPEPLTLRW // ID M0R642_RAT Unreviewed; 243 AA. AC M0R642; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 2. DT 12-SEP-2018, entry version 46. DE SubName: Full=RT1 class I, locus T24, gene 3 {ECO:0000313|Ensembl:ENSRNOP00000064880}; GN Name=RT1-T24-3 {ECO:0000313|Ensembl:ENSRNOP00000064880, GN ECO:0000313|RGD:1624211}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000064880, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000064880, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000064880, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000064880} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000064880}; RG Ensembl; RL Submitted (FEB-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044364; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PRIDE; M0R642; -. DR Ensembl; ENSRNOT00000070903; ENSRNOP00000064880; ENSRNOG00000045924. DR RGD; 1624211; RT1-T24-3. DR eggNOG; ENOG410J90V; Eukaryota. DR eggNOG; ENOG41117CA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M0R642; -. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000045924; Expressed in 9 organ(s), highest expression level in spleen. DR ExpressionAtlas; M0R642; baseline and differential. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 243 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004003824. FT DOMAIN 119 207 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 243 AA; 27925 MW; 3AAB9C637F3EFDB9 CRC64; MWALIFWFLT HPQETGARSH SLHYSYSAVT EPGPGVPAFF ASGFVDNQPF IHYDSRKMEA EPCADWLREN PYYFDEETQV FTNRMKIFQL SLRNIQQYYN SSGDRSQRAD GFHQQADPPQ TTVTCHPRPE GDVTLRCWAL GFYPADITLT WQLNGEDLTQ DMELVETRPA GDGTFQKWAS VVVPLGKEQK YTCRVEHEGL PEPVSLTWEP LQLTTSKTEV CARGRWGLQA TTLCVLMVFW AWC // ID M0R866_RAT Unreviewed; 245 AA. AC M0R866; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 2. DT 12-SEP-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSRNOP00000065658}; DE Flags: Fragment; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000065658, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000065658, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000065658, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000065658} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000065658}; RG Ensembl; RL Submitted (FEB-2013) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044394; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044395; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044396; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044397; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; M0R866; -. DR Ensembl; ENSRNOT00000075244; ENSRNOP00000065658; ENSRNOG00000050998. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; M0R866; -. DR OrthoDB; EOG091G0LFP; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000050998; Expressed in 8 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 184 210 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 81 169 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSRNOP00000065658}. SQ SEQUENCE 245 AA; 27015 MW; 6BDF5D613C6F28C8 CRC64; XDGSLLRGYV QFAYDGRDYI ALNEDLKTWM AADTAAQMTR SKWDQAAEAE RKRAYLEGEC VEGLRRYLEL GKETLLRSDP PKAHVTLHPR HEGDVTLRCW ALGFYPADIT LTWQLNGEDL TQDMELVETR PAGDGTFQKW ASVVVPSGKE QNYTCHVEHE GLPEPLTLRW ESPPSTDSNM ETNVIYVVVG AISAVAIIAA VIIGALVCVV RKRWIKTGGK GGDYAPALGK DSCQSSDVSL ADCEA // ID M3VV43_FELCA Unreviewed; 362 AA. AC M3VV43; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 40. DE SubName: Full=Saoe class I histocompatibility antigen, A alpha chain-like precursor {ECO:0000313|Ensembl:ENSFCAP00000000583}; GN Name=FLAI-K {ECO:0000313|Ensembl:ENSFCAP00000000583}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000000583, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000000583, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000583, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of the cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000000583} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000583}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000000583} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000583}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AANG03366443; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03366444; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03366445; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03366446; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3VV43; -. DR STRING; 9685.ENSFCAP00000000583; -. DR Ensembl; ENSFCAT00000000629; ENSFCAP00000000583; ENSFCAG00000000629. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; M3VV43; -. DR OMA; LENICVQ; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000011712; Chromosome B2. DR Bgee; ENSFCAG00000000629; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014188331. FT TRANSMEM 306 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 362 AA; 40826 MW; 4C9CD85BAFA03C11 CRC64; MRFVMPRTLL LLLSEALAVT QTRAGSHSLR YFYTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAPNPREE PRAPWMEQEG PEYWDEQTRM VKDHAQTFRL SLNNLRGYYN QSVSESHSLQ RMYGCDIGPD GRLLRGYSQD AYDGEDYIAL NEDLRSWTAA DTAAQITRRK WEVAGEAERW RNYLEGTCVE GLPKYLEMGK ETLLRAESPD THVTRHPISD HEVTLRCWAL GFYPAEITLT WQSDGQDHTQ DAELVDTRPS GDGTFQKWAA VVVSSGEEQR YTCHVQHEGL PEPITLRWEP SSQPSIPILG IIAGVAVLVV IVVVGAVIWR KKFSGGKGPR YSHAARDDST QGSDSSVMAP KV // ID M3VVK6_FELCA Unreviewed; 406 AA. AC M3VVK6; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 40. DE SubName: Full=Saoe class I histocompatibility antigen, A alpha chain-like precursor {ECO:0000313|Ensembl:ENSFCAP00000000816}; GN Name=FLAI-K {ECO:0000313|Ensembl:ENSFCAP00000000816}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000000816, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000000816, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000816, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of the cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000000816} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000816}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000000816} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000816}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AANG03366443; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03366444; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03366445; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03366446; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9685.ENSFCAP00000000816; -. DR Ensembl; ENSFCAT00000000878; ENSFCAP00000000816; ENSFCAG00000000629. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; M3VVK6; -. DR OMA; VHEIHER; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000011712; Chromosome B2. DR Bgee; ENSFCAG00000000877; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 350 373 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 253 341 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 406 AA; 46121 MW; E5F863FB0C000D50 CRC64; MTRPRFTHLL VSGFRRSQSA APRFRGIKFP HPPPETHISP QTPRMRFLMS RTVLLLLLGA LAAPQTWAGS HSLRYFYTAM SRPGLGEPRF IAVGYVDDTQ FVRFDSDAPN PRMEPRAPWV EQVGPEYWDQ ETRNEKNNAQ IFRVDLNTML RYYNQSESGS HNIQWMYGCD VGPDRRFLRG YSQDSYDGKD YIALNEDLRS WTAADTAAQI TRRKWEEAGA AEQERNYLEG TCVEWLAKYL DMGKETLLRA ESPNTRVTRH PISDREVTLR CWALGFYPAE ITLTWQRDGQ DHTQDAELVE TRPAGDGTFQ KWAAVVVSSG EEQRYTCHVQ HEGLREPITL RWEPSSQPSI PILGIIAGVA VLVVIVVVGA VIWRKKFSGG KGPRYSHAAR DDSTQGSDSS VMAPKV // ID M3W522_FELCA Unreviewed; 343 AA. AC M3W522; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=Hemochromatosis {ECO:0000313|Ensembl:ENSFCAP00000005543}; GN Name=HFE {ECO:0000313|Ensembl:ENSFCAP00000005543}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000005543, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000005543, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005543, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of the cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000005543} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005543}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000005543} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005543}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AANG03020880; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3W522; -. DR STRING; 9685.ENSFCAP00000005543; -. DR Ensembl; ENSFCAT00000005969; ENSFCAP00000005543; ENSFCAG00000005968. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M3W522; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000011712; Chromosome B2. DR Bgee; ENSFCAG00000005968; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IBA:GO_Central. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 292 313 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 194 283 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 343 AA; 38493 MW; FEC5AA7750459FF2 CRC64; GGPRGCPVTF SPGSHSLSYL FMGASVPDLG LPLFEALGYV DDQLFVSYNH ESRRAEPRAQ WLEDGAPSQL WLQLSQSLKG WDHMFIVDFW TIMDNHNHSK ESHTLQVILG CEVREDNSTR GFWNYGYDGQ NYLEFRPETL DWRAAEPRAW ATKLEWEVNA IRAKQNRAYL ERDCPVQLQS LLALGTGVLD RQVPPLLKVT HHVASAVTTL RCQALNFYPQ NITMRWLKDR RPLEAKDVEP QDVLPNGDGT YQGWLAVAVP PGEEHRYTCL VEHPGLNQPL AATWEPSVPS TLVIGAISGI AVCVILFVIG VLFRIFRKRQ ASRGLNVSPG CQGERQVSAS VGF // ID M3WAZ3_FELCA Unreviewed; 269 AA. AC M3WAZ3; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 38. DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSFCAP00000008525}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSFCAP00000008525}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000008525, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000008525, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008525, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of the cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000008525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008525}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000008525} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008525}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AANG03035609; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3WAZ3; -. DR STRING; 9685.ENSFCAP00000008525; -. DR Ensembl; ENSFCAT00000009201; ENSFCAP00000008525; ENSFCAG00000009199. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M3WAZ3; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR Proteomes; UP000011712; Chromosome E2. DR Bgee; ENSFCAG00000009199; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; IBA:GO_Central. DR GO; GO:0019770; F:IgG receptor activity; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 208 229 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 110 197 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 269 AA; 29015 MW; A6A282781014F04D CRC64; ASPPRSVPLP QSILLFLDLS STLTESHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLS YNNMRAQAEP CGAWVWENQV SWYWEKETTD LRNKQELFLE ALKVLGEGEP PSMRLKARPG SPGFSVLTCS AFSFYPPELQ LRFLRNGLAA GSGEGDFGPN GDGSFHAWSS LTVKSGDEHH YRCLVQHAGL PQPLTVELES PAKSSMPVVG IVIGLLLLTA AAAGGALLWR RMRNGLPAPW ISLRGDDVGA LLPTPGLPKD DINAFSAAA // ID M3WMH5_FELCA Unreviewed; 367 AA. AC M3WMH5; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 41. DE SubName: Full=Saoe class I histocompatibility antigen, A alpha chain-like precursor {ECO:0000313|Ensembl:ENSFCAP00000014261}; GN Name=FLAI-K {ECO:0000313|Ensembl:ENSFCAP00000014261}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000014261, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000014261, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014261, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of the cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000014261} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014261}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000014261} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014261}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AANG03366443; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03366444; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03366445; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03366446; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9685.ENSFCAP00000014261; -. DR Ensembl; ENSFCAT00000015383; ENSFCAP00000014261; ENSFCAG00000000629. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; M3WMH5; -. DR OMA; TSRMKIF; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000011712; Chromosome B2. DR Bgee; ENSFCAG00000015379; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 367 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014192533. FT TRANSMEM 319 342 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 222 308 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 367 AA; 41745 MW; 1C54AE58EFA84009 CRC64; MRFVMPRTLL LLLSEALAVT QTRAGSHSLR YFYTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAPNPREE PRAPWMEQEG PEYWDEQTRM VKDHAQTFRL SLNNLRGYYN QSVRVYFRFH LNHCCSGESH SLQRMYGCDI GPDGRLLRGY SQDAYDGEDY IALNEDLRSW TAADTAAQIT RRKWEVAGEA ERWRNYLEGT CVEGLPKYLE MGKETLLRAE SPDTHVTRHP ISDHEVTLRC WALGFYPAEI TLTWQSDGQD HTQDAELVDT RPSGDGTFQK WAAVVVSSGE EQRYTCHVQH EGLPEPITLR WEPSSQPSIP IPGIIAAVVV LVVIVVVGAV IWRKKFSGRN RGSDSFLMAP KGKTLEG // ID M3WNZ4_FELCA Unreviewed; 388 AA. AC M3WNZ4; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 35. DE SubName: Full=Saoe class I histocompatibility antigen, A alpha chain-like precursor {ECO:0000313|Ensembl:ENSFCAP00000015735}; GN Name=FLAI-K {ECO:0000313|Ensembl:ENSFCAP00000015735}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000015735, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000015735, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000015735, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of the cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000015735} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000015735}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000015735} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000015735}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AANG03366443; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03366444; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03366445; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03366446; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3WNZ4; -. DR Ensembl; ENSFCAT00000018713; ENSFCAP00000015735; ENSFCAG00000000629. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000011712; Chromosome B2. DR Bgee; ENSFCAG00000018696; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 388 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014125909. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 388 AA; 43955 MW; C5358361907C6060 CRC64; MRFVMSRTVL LLLLGALAAP QTWAGSHSLR YFYTAMSRPG LGEPRFISVG YVDDTQFVRF DSDAPNPRYE PRAPWVEQVG PEYWDRNTRN AKDNAQKFRV DLNTMLRYYN QSGSGSHNIQ RMYGCDVGPD RRFLRGYSQV SYDGKDYISL NKDLRSYTAA DTAAQITRRK WEEAGGAEQE RNYLEDTCVE WLAKYLDMGK ETLLRAESPD TRVTRHPISD REVTLRCWAL GFYPAEITLT WQHDGQDHTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPITLRWGK EGLGSSPCQG TQGPSREFHK VRTEARYLGL SPSFPFQSHP LSDDSTQGSD SSLMAPKGKT LEGEVGRSGG TRDTLSMRGA VEMWHLCD // ID M3WPC3_FELCA Unreviewed; 406 AA. AC M3WPC3; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 41. DE SubName: Full=Saoe class I histocompatibility antigen, A alpha chain-like precursor {ECO:0000313|Ensembl:ENSFCAP00000016006}; GN Name=FLAI-K {ECO:0000313|Ensembl:ENSFCAP00000016006}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000016006, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000016006, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016006, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of the cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000016006, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016006, RC ECO:0000313|Proteomes:UP000011712}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000016006} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016006}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. RN [4] {ECO:0000313|Ensembl:ENSFCAP00000028948} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000028948}; RG Ensembl; RL Submitted (JAN-2018) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AANG03366443; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03366444; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03366445; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03366446; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSFCAT00000018558; ENSFCAP00000016006; ENSFCAG00000000629. DR Ensembl; ENSFCAT00000040366; ENSFCAP00000028948; ENSFCAG00000000629. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; M3WPC3; -. DR OMA; TDPERTH; -. DR OrthoDB; EOG091G0M1Y; -. DR Proteomes; UP000011712; Chromosome B2. DR Bgee; ENSFCAG00000018113; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 350 373 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 253 341 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 406 AA; 46153 MW; A4E3FD82F015EC8B CRC64; MTRPRFTHLL VSGFRRSQSA APRFRGIKFP HPPPETHISP QTPRMRFLMS RTVLLLLLGA LAAPQTWAGS HSLRYFYTAM SRPGLGEPRF IAVGYVDDTQ FVRFDSDAPN PRMEPRAPWV EQVGPEYWDQ ETRNEKNNAQ IFRVDLNTML RYYNQSESGS HNIQWMYGCD VGPDRRFLRG YSQDSYDGKD YIALNEDLRS WTAADTAAQI TRRKWEEAGA AEQERNYLEG TCVEWLAKYL DMGKETLLRA ESPNTRVTRH PISDREVTLR CWALGFYPAE ITLTWQRDGQ DHTQDAELVE TRPAGDGTFQ KWAAVVVSSG EEQRYTCHVQ HEGLREPITL RWEPSSQPSI PILGIIAGVA VLVVTVVVGA VIWRKKFSGR KGPSYSHAAR DDSTQGSDSS LMAPKV // ID M3WPT0_FELCA Unreviewed; 292 AA. AC M3WPT0; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 41. DE SubName: Full=Alpha-2-glycoprotein 1, zinc-binding {ECO:0000313|Ensembl:ENSFCAP00000016355}; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSFCAP00000016355}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000016355, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000016355, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016355, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of the cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000016355} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016355}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000016355} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016355}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AANG03361513; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_006942027.2; XM_006941965.2. DR ProteinModelPortal; M3WPT0; -. DR Ensembl; ENSFCAT00000018233; ENSFCAP00000016355; ENSFCAG00000018968. DR GeneID; 101097692; -. DR KEGG; fca:101097692; -. DR CTD; 563; -. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M3WPT0; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000011712; Chromosome E3. DR Bgee; ENSFCAG00000018968; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 292 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014118845. FT DOMAIN 206 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 292 AA; 33493 MW; 89E9FD87C9FCB81E CRC64; MGTMVSVLLS LLLLLGPAVP QETQAGSYRL SFLYTGVSRP TDSLPSFQAT AYLNDQVFFH YDSKSRKAIP LDPWSQMEGI EDWEKESELQ QARESIFMET LQDIMDYYKD REGSHTFQGR FGCELLNNKS SGAFWKYAYD GQNFIEFNRE IPGWVPQDPA ALNTKRKWEA EEVYVQRAKA YLEEECPAML RRYLQYGKAF LDRQDPPSMS ITRTPGEDTI KCWASDFYPQ DIDLHWIQGG NTVETEVRGD LLPSGNGTYL SWVSLTVSPW RTKNTVFCRI VHSSLDQPLT GL // ID M3WTB8_FELCA Unreviewed; 381 AA. AC M3WTB8; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFCAP00000017604}; GN Name=LOC101094232 {ECO:0000313|Ensembl:ENSFCAP00000017604}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000017604, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000017604, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017604, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of the cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000017604} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017604}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000017604} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017604}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AANG03364303; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3WTB8; -. DR STRING; 9685.ENSFCAP00000017604; -. DR Ensembl; ENSFCAT00000030113; ENSFCAP00000017604; ENSFCAG00000026141. DR eggNOG; ENOG410IGE3; Eukaryota. DR eggNOG; ENOG41114P3; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M3WTB8; -. DR OMA; RMFGCEI; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000011712; Chromosome A1. DR Bgee; ENSFCAG00000026141; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 381 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014142402. FT TRANSMEM 336 355 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 234 320 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 381 AA; 43218 MW; 370D4B90F5F54E3C CRC64; MLLLLQLLSL LRELTAESPW GLPVVADGPA SLAKVVMAEL ADLKLENKPW PGGTHSLHYH YLALSEPGPD LPQFLAVGYV DDQPFIHYDS RVDRAKPQAP WMAAVDTQYW ETETQKQRAW AKVQQVETWT VMGYHNQSSG THSTQRTFGC EIREDGCTSS FWQFGFDGQD HLSLDLETLS WVSAKPVAVQ TKRWWETERC YAEYDKAYLE GLCLTSLHRY LELGSQSLTR KEPPKVQVTR HTAEDGSITL RCWARGFYPR DISLSWWLGE EELVQETEYV ETRPGGDGTY QTWAAVRVPA RMENGYICHV QHSSLNHTLT VAWEAPSHQW ITSAKVISII FTITFLLVAG VLTFIKQYSQ GGEEPHNSQN PMSVEAAQLL C // ID M3WUB7_FELCA Unreviewed; 306 AA. AC M3WUB7; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFCAP00000017954}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000017954, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000017954, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017954, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of the cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000017954} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017954}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000017954} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017954}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AANG03366452; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3WUB7; -. DR Ensembl; ENSFCAT00000027631; ENSFCAP00000017954; ENSFCAG00000018113. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; M3WUB7; -. DR OMA; ECAWIGS; -. DR OrthoDB; EOG0907079Q; -. DR Proteomes; UP000011712; Chromosome B2. DR Bgee; ENSFCAG00000021900; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 306 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014152170. FT DOMAIN 191 277 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 306 AA; 34967 MW; BBB51BB415BC3A44 CRC64; ERVIMPRTLL LLLSEALAMT QTWAGSHSLR YFSTVVSRPG RGEPRYLEVG YVDDKQFVRF DSDAPSPRWL EQEGPEYWDR ETLRVKETAQ ISRVSLQTAL GYYNQSESGS HTLQDMYGCD VGPDGRFLRG YSQLAYDGED YIALNEDLCS WTAADTAAQI TRRKWEVAGV AEDFRNYMGK ETLLRAVTES PKTRVTRHPI SDREVTLRCW ALGFYPAEIT LTWQRDGQDH TQDTELVDTR PAGDGTFQKW AAVVVPSGEE QRYTCHVQHE GLPEPITLRW VTNRSTDNVV CHVQDPLFFH LGHLSD // ID M3WX06_FELCA Unreviewed; 345 AA. AC M3WX06; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFCAP00000018895}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000018895, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000018895, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018895, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of the cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000018895} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018895}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000018895} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018895}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AANG03366442; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3WX06; -. DR STRING; 9685.ENSFCAP00000018895; -. DR Ensembl; ENSFCAT00000027264; ENSFCAP00000018895; ENSFCAG00000000877. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; M3WX06; -. DR OMA; FQRMIGC; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000011712; Chromosome B2. DR Bgee; ENSFCAG00000022105; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 345 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014117441. FT TRANSMEM 298 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 201 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 345 AA; 39047 MW; 516C863755CFE446 CRC64; MRVVTPPTLL LLLVGRGLSP SAPAGSHSLR YFYTAVSRPG LGEPRFIAFV RFDSDAPNPR MEPREPWVEQ EGPEYWDRET RNAKDTAQSF RVNLNTMLRY YNQSESGSHN IQWMYGCDLG PDGLLLRGYT QWAYDGADYI ALNEDLRSWT VADTAAHITR RKWEVAGEAA RYRKYLEDTC LAGLRRYLEM GKETLLRAES PNTRMTRHPI SDREVTLRCW ALGFYPAEIT LTWKRDGQDH TQDTELVETR PAGDGTFQKW AAVVVPSGEE QRYTCHVQHE GLPEPITLRW EPSSQPSIPI LGIIVAVVVL VVTVVVGAVI WRKKCSGRNR VGGCEFSCPT GGFPR // ID M3WYM6_FELCA Unreviewed; 397 AA. AC M3WYM6; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFCAP00000019466}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000019466, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000019466, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019466, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of the cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000019466} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019466}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000019466} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019466}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AANG03366440; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03366441; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03366442; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9685.ENSFCAP00000019466; -. DR Ensembl; ENSFCAT00000027171; ENSFCAP00000019466; ENSFCAG00000027242. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; M3WYM6; -. DR OMA; NTENPEY; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000011712; Chromosome B2. DR Bgee; ENSFCAG00000027242; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 347 373 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 253 339 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 397 AA; 45223 MW; A924C37EADEAF8E5 CRC64; MTRPRFTHLL VSSFWRSQSA APWFRGIKFP HRPPETHICP QTPRMRFVMS RTLLLLLLGA LAAPQTWAGS HSLRYFYTAV SRPGLGEPRF ISVGYVDDTQ FVRFDSDAPN PREEPRAPWV EQVGPEYWDE QTRIVKNTAQ IFRVDLNTML RYYNQSESGS HNIQRMYGCD VGPDRRFLRG YSQDSYDGKD YIALNEDLRS WTAADTAAQI TRRKWEEAGA AEQERNYLEG TCVEWLAKYL DMGKETLLRA ESPNTRVTRH PISDREVTLR CWALGFYPAE ITLTWQRDGQ DHTQDAELVE TRPAGDGTFQ KWAAVVVPSG EEQRYTCHVQ HEGLPEPITL RWEPSSLPFI TILGIIAGVA VLVVTVVVGA VIWRKKFSGG KGPSYFHAAH KYGGGDP // ID M3WZF2_FELCA Unreviewed; 252 AA. AC M3WZF2; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFCAP00000019742}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000019742, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000019742, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019742, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of the cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000019742} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019742}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000019742} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019742}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AANG03366446; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSFCAT00000028384; ENSFCAP00000019742; ENSFCAG00000015379. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000011712; Chromosome B2. DR Bgee; ENSFCAG00000018696; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 205 228 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 108 194 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 252 AA; 28202 MW; 8108F974DFF5C49B CRC64; SCCCRGALAV TETWAGSHSL RYFDTIVSRP GLGEPRFIAV GYVDDTQFER LDSDTPNPRA EPRAPWVEKE GPQYWDRNTR IYLDTAQVSR VNLNMMLRCY NQSDSESPNT RVTRHPISDR EVTLRCWALG FYLAEITLTW QSDGEDHTQD TELVETRPAG DGTFQKWAAV VVSSGEEQRY TCHVQHEGLP EPITLRWEPS SLPSIPIPGI MAGVAILVVT VVVGAVIWRK KFSGRNRVGG SEFTCPAGGF PR // ID M3XG54_FELCA Unreviewed; 333 AA. AC M3XG54; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFCAP00000025615}; GN Name=LOC101099296 {ECO:0000313|Ensembl:ENSFCAP00000025615}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000025615, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000025615, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000025615, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of the cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000025615} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000025615}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000025615} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000025615}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AANG03329322; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_019685898.1; XM_019830339.1. DR ProteinModelPortal; M3XG54; -. DR Ensembl; ENSFCAT00000031464; ENSFCAP00000025615; ENSFCAG00000018696. DR GeneID; 101099296; -. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; M3XG54; -. DR OMA; KTHITHY; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000011712; Chromosome B2. DR Bgee; ENSFCAG00000018696; Expressed in 3 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 333 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014142396. FT TRANSMEM 305 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 333 AA; 37766 MW; D135FDFA08161EA9 CRC64; MRVVMPRTLL LLLSGALAVT QTCAGSHSLM YFGTAVSRPS LGEPRYLEVG YVDDTQFARF DSDASSPRME PRVHWLKQEA PGYWEQETRG AKDTAQTFRL SLNTLRGYYN QSEAGSHTIQ WLSSCEVGPD WRLLRGYWQF AYDGEDYIAL NEDLRSWTAA DTAAQITRRK WEAAGAAEHQ RNDLQVTCVE WLRKYLERGN KTLLRTDPPK THITHYPTSD HDVTLKCWAL GFYPAEITLT WQRDGEDLIQ ETEFVDTRPG GDGTFQKWVA VVVPSGEEQR YTCHVQHGGL PKPLMLKWES PSQRIIPMVG IVAGLVSFVV ISAVVVGAVI WRR // ID M3XHB2_LATCH Unreviewed; 343 AA. AC M3XHB2; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000022118}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000022118, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000022118} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000022118}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000022118} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AFYH01228263; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01228264; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01228265; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSLACT00000025927; ENSLACP00000022118; ENSLACG00000005685. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 343 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004043446. FT TRANSMEM 300 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 343 AA; 39147 MW; FEDF0CCCCBFB8ABD CRC64; MILVFLMGFL CLEGVSGSHS WKAYLTFLKG DSRLPEFMAM HMVDDIQIMY YDSEIGHCVT KQDWMETVNK EVSNYWNTQG DALRDRQKNL KFMVKALMNE SNQSSGVHTF QNLYGCTLND DDTTTGFWNS GYDGDDFSNF DTRGMTLSPG QGKSRMVEKF CSVDQKNVPH TKVYLEQECI EWLRNFLRYG KQKLERKVRP KVVVYDRLAS ESNSIVLTCL ATGFYPRAID VSWVRDGETQ MDSAATEGIL PNEDETYQIR KRLEIGSEDK HNYTCRVEHS STELPQIVAW APSPGLKDGI LVPVLVVSVL VLVLVLLLSV TGFVVWKKKK PGNQKKDILY FGH // ID M3XPU6_MUSPF Unreviewed; 368 AA. AC M3XPU6; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 20-JUN-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000001096}; OS Mustela putorius furo (European domestic ferret) (Mustela furo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; OC Mustelinae; Mustela. OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000001096, ECO:0000313|Proteomes:UP000000715}; RN [1] {ECO:0000313|Ensembl:ENSMPUP00000001096} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000001096}; RA Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S., RA Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., RA Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J., RA Walker B.J., Young S., Birren B., Lindblad-Toh K.; RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMPUP00000001096} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEYP01099521; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3XPU6; -. DR Ensembl; ENSMPUT00000001119; ENSMPUP00000001096; ENSMPUG00000001105. DR eggNOG; ENOG410IGE3; Eukaryota. DR eggNOG; ENOG41114P3; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M3XPU6; -. DR OMA; RMFGCEI; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000000715; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000715}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000715}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 368 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004043747. FT TRANSMEM 310 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 42490 MW; 565488270DFDE47C CRC64; LFNRNPQFLL LLMANTLVRL SYVFTGTHSL HYHYLALSEP GPDLPQFLAV GYVDDQPFIH YDSRVDRAKP QAPWMATVDA QYWETETQKQ RAWAKVQQVE TWTVMGYHNQ STAFSPTYAG MHSTQRMFGC EIREDGHTHS FWQFGFDGQD HLSLDLETLN WVSAKPAAMR TKSWWETERC YAEYDKAYLE GLCLVSLRRY LELGGQSLTR KEPPTVQVTR HTAQDGGITL KCWARGFYPR DISLSWWLGE EELVLETEYV ETRPSGDGTY QTWAAVQVPA RMEDRYTCHV QHSGLNHTFT VTWEAPPHQW ITSAVVIPML IFLLLTAGVL IFIKQYSQGR WEEKKVPSQL AKPCREKGSS PILPAERF // ID M3XSL7_MUSPF Unreviewed; 266 AA. AC M3XSL7; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000002067}; OS Mustela putorius furo (European domestic ferret) (Mustela furo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; OC Mustelinae; Mustela. OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000002067, ECO:0000313|Proteomes:UP000000715}; RN [1] {ECO:0000313|Ensembl:ENSMPUP00000002067} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000002067}; RA Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S., RA Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., RA Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J., RA Walker B.J., Young S., Birren B., Lindblad-Toh K.; RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMPUP00000002067} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEYP01106208; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3XSL7; -. DR Ensembl; ENSMPUT00000002110; ENSMPUP00000002067; ENSMPUG00000002088. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; M3XSL7; -. DR OMA; GYCQEAY; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000000715; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000715}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000000715}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 195 215 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 95 181 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 266 AA; 29998 MW; B4A5D35A62A9E59E CRC64; GSHTIQRMYG CDVGPDGRLL RWYSQFAYDG ADYIDLNEDL RSWTAADTAA QITRRKWEAK GYTEHDRNYL EVTCVEWLRR YLENGKEMLL HAEPPDIRVT HHPISNRDVT LRCWALGFYP AEITLTWQRD GEDLTQDTEL VETRPAGDGT FQKWAAVVVP SGEKQTYTCH VQHEGLPKPI TEKWEPPPPT NPITWISGGL IAVIAVIGVG AVICWKMCSE RRRPGYSHAA GDESAQGSNV SLTAPKEQYL LSKDGCFHLG AHCRCP // ID M3XSN5_MUSPF Unreviewed; 304 AA. AC M3XSN5; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000002085}; OS Mustela putorius furo (European domestic ferret) (Mustela furo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; OC Mustelinae; Mustela. OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000002085, ECO:0000313|Proteomes:UP000000715}; RN [1] {ECO:0000313|Ensembl:ENSMPUP00000002085} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000002085}; RA Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S., RA Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., RA Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J., RA Walker B.J., Young S., Birren B., Lindblad-Toh K.; RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMPUP00000002085} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEYP01106226; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AEYP01106227; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AEYP01106228; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3XSN5; -. DR Ensembl; ENSMPUT00000002128; ENSMPUP00000002085; ENSMPUG00000002106. DR GeneTree; ENSGT00900000141162; -. DR InParanoid; M3XSN5; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000000715; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF00129; MHC_I; 2. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000715}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000715}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 247 268 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 7 52 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 54 145 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 288 303 MHC_I_C. {ECO:0000259|Pfam:PF06623}. SQ SEQUENCE 304 AA; 33866 MW; DC75AFCBA7D40F8F CRC64; SPSAPAGSHY LRYFYTRVSR PGRGEPRFIA FGYVEDTHFL RFDSDFASCR VGPGSHTIQS MYGCDVGPDG HLLRRYSQDA YDGADYLALN EDLRSWTAAD REAQVTHRDH RNWEAACEAD HERNYLEVTC VEWLRRHLEN GKETLLRSRR ENGLSGRTPL FNGTIEESSL SQEAGGDHSC NNPSAVPFDP DSHLGNPDFL SQGLFLHWGR ASSQGKQKAF WVRTQTRGLG LSSSLPFPEP PPPTTPITWI IAGLTLLMVT VTFGAVIWRK KLSGKEEKDQ ASLKHDVSDD NAQGSDVSLM APKG // ID M3XU17_MUSPF Unreviewed; 355 AA. AC M3XU17; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSMPUP00000002567}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSMPUP00000002567}; OS Mustela putorius furo (European domestic ferret) (Mustela furo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; OC Mustelinae; Mustela. OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000002567, ECO:0000313|Proteomes:UP000000715}; RN [1] {ECO:0000313|Ensembl:ENSMPUP00000002567} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000002567}; RA Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S., RA Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., RA Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J., RA Walker B.J., Young S., Birren B., Lindblad-Toh K.; RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMPUP00000002567} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEYP01068232; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AEYP01068233; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_012919497.1; XM_013064043.1. DR RefSeq; XP_012919499.1; XM_013064045.1. DR RefSeq; XP_012919500.1; XM_013064046.1. DR RefSeq; XP_012919501.1; XM_013064047.1. DR STRING; 9669.ENSMPUP00000002567; -. DR Ensembl; ENSMPUT00000002620; ENSMPUP00000002567; ENSMPUG00000002596. DR GeneID; 101672498; -. DR CTD; 2217; -. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M3XU17; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR Proteomes; UP000000715; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019864; F:IgG binding; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000715}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000715}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 355 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004043923. FT TRANSMEM 299 320 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 201 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 355 AA; 38909 MW; 7F86594A3D7B15EB CRC64; MWVPRPRSWG LGFLLFLLPT VRAESNLSLL YHLTAVSSPA PGAPAFWVSG WLGPQQYLSY NNLRAEAEPC GAWVWENQVS WYWEKETTDL RSKQELFLEG LKALGKGGPY TLQGLLGCEL GPDNASVPVA KFALNGEDFM TFDPKLGTWD GDWPETETIQ KTWMQHAGAV SKERTFLLNS CPQRLLGHLE RGRGNLEWKE PPSMRLKARP GSPGFSVLTC SAFSFYPPEL QLRFLRNGLA VGSGEGDFGP NGDGSFHAWS SLTVKSGDEH HYRCVVQHAG LPQPLTVELE SPARSSVPVI GIVVGFLLLM AVAAGGALLW RRMRKGLPAP WMSLRGDDDV GALLPAPGVP KDADS // ID M3YBA1_MUSPF Unreviewed; 403 AA. AC M3YBA1; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000008608}; OS Mustela putorius furo (European domestic ferret) (Mustela furo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; OC Mustelinae; Mustela. OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000008608, ECO:0000313|Proteomes:UP000000715}; RN [1] {ECO:0000313|Ensembl:ENSMPUP00000008608} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000008608}; RA Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S., RA Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., RA Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J., RA Walker B.J., Young S., Birren B., Lindblad-Toh K.; RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMPUP00000008608} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEYP01095349; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_012904561.1; XM_013049107.1. DR ProteinModelPortal; M3YBA1; -. DR STRING; 9669.ENSMPUP00000008608; -. DR Ensembl; ENSMPUT00000008749; ENSMPUP00000008608; ENSMPUG00000008677. DR GeneID; 101676902; -. DR CTD; 3077; -. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M3YBA1; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000000715; Unassembled WGS sequence. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0042446; P:hormone biosynthetic process; IEA:Ensembl. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:Ensembl. DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IEA:Ensembl. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000715}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000715}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 360 384 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 262 349 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 403 AA; 45187 MW; ED2B28F7B2F6C436 CRC64; MWEWGRGWEL QEGGGSPHPT AGEERAPRLW GGGAERPCSS RVVGGPRRSR DAALLPPSPF RSPQRCPLAF SPGSHSLRYL FMGASVPDLG LPLFEALGYV DDQLFVSYSH ESRRAEPRAQ WVQGGATSQL WLQLSQSLKG WDHMFIVDFW TIMDNHNHSK VTKLEVLSES HTLQVILGCE VQEDNSTRGF WKYGYDGQNH LEFCPETLDW RAAEPKAQAT KLEWEVNKIR AKQNRAFLER DCPKQLQRLL ELGRGVLDRR VPPLVKVTQR VASAVSTLRC QALNFYPQNI TMKWLKDGQP LDATDVEPKD VLPNGDGTYQ GWAALAVAPG EEQRYTCQVE HPGLDQPLTA AWEAPMSGTL VIGVISGIAV CIILLFIGIL FRILRKRQAS REAMGDYVLA ECK // ID M3YG14_MUSPF Unreviewed; 245 AA. AC M3YG14; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 21. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000010271}; OS Mustela putorius furo (European domestic ferret) (Mustela furo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; OC Mustelinae; Mustela. OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000010271, ECO:0000313|Proteomes:UP000000715}; RN [1] {ECO:0000313|Ensembl:ENSMPUP00000010271} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000010271}; RA Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S., RA Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., RA Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J., RA Walker B.J., Young S., Birren B., Lindblad-Toh K.; RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMPUP00000010271} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEYP01034353; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3YG14; -. DR Ensembl; ENSMPUT00000010434; ENSMPUP00000010271; ENSMPUG00000010344. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; M3YG14; -. DR OMA; QIAKRPL; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000000715; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000715}; KW Reference proteome {ECO:0000313|Proteomes:UP000000715}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 245 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004044830. FT DOMAIN 29 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 245 AA; 27713 MW; 88482F04360C5C89 CRC64; GAAVWGQSLL LLPHILLLSP GWQRDALLLS YNFSITSQAR PGQPWCEIQG QVNGNEFLYY ACGSKRVISV GPWGMKLKDT AFWDTQMEPL EDLGEEFRKK LLDIKAEIFT KSDSLTLQGR LMCERGAHGH SRRSWRFVFN EQFTCLFDPE NRKWIQFPPG GQQVKDMLDG DRELTELLMK IANGDCKGWL QKLREHSNEM QETVGAPATS LHVPLVKDAA IRPITSVLHV VLTHSILLVV QGMVL // ID M3YG41_MUSPF Unreviewed; 261 AA. AC M3YG41; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000010298}; OS Mustela putorius furo (European domestic ferret) (Mustela furo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; OC Mustelinae; Mustela. OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000010298, ECO:0000313|Proteomes:UP000000715}; RN [1] {ECO:0000313|Ensembl:ENSMPUP00000010298} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000010298}; RA Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S., RA Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., RA Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J., RA Walker B.J., Young S., Birren B., Lindblad-Toh K.; RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMPUP00000010298} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEYP01034362; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_004753613.2; XM_004753556.2. DR ProteinModelPortal; M3YG41; -. DR Ensembl; ENSMPUT00000010462; ENSMPUP00000010298; ENSMPUG00000010372. DR GeneID; 101685787; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; M3YG41; -. DR OMA; GSLICER; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000000715; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000715}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000715}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 32 {ECO:0000256|SAM:SignalP}. FT CHAIN 33 261 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004045207. FT TRANSMEM 242 259 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 44 208 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 102 122 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 261 AA; 29147 MW; DD9E37CB3DD17D4A CRC64; MSFPRRTGWT GVPSGRGLGL LLCVLLPVCA TASCSREFRG PLSLNQNFSI TSQPRPGQPW CEIQGQVNGN KFLYYVCGSK QVIHTGPYGM KMKNTAFWET QMETLEDLGE EFRKKLLDIK AEFVTKSGDS LTMQGSLICE RGADGHTRGS WKFAFNGQLT HLFDPENRKW TVVPPGGQQF RGTLDNDREL NKLLVRTANG DCKRWLQHVW EHWDEMQETT VPPATRQGTA PGKATAIGPC TWIFPLLLSC AVMMGILVGD H // ID M3YG48_MUSPF Unreviewed; 249 AA. AC M3YG48; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 21. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000010305}; OS Mustela putorius furo (European domestic ferret) (Mustela furo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; OC Mustelinae; Mustela. OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000010305, ECO:0000313|Proteomes:UP000000715}; RN [1] {ECO:0000313|Ensembl:ENSMPUP00000010305} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000010305}; RA Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S., RA Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., RA Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J., RA Walker B.J., Young S., Birren B., Lindblad-Toh K.; RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMPUP00000010305} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEYP01034364; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3YG48; -. DR Ensembl; ENSMPUT00000010470; ENSMPUP00000010305; ENSMPUG00000010380. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; M3YG48; -. DR OMA; NISMGDC; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000000715; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000715}; KW Reference proteome {ECO:0000313|Proteomes:UP000000715}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 249 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004045209. FT DOMAIN 33 199 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 249 AA; 28251 MW; 15222D9283CE3BC2 CRC64; AEPTGATKFT WCLRLLFLLL FLVREIKAAP AALSLSYNFS ITSQPRPGPS WCEIQGQVNG NKFLSYACGS KEIKPVGSLG MKLKDTAFWG TQREPLKDLE EELRKKLLDI KTEIFTKSDS LTLQGRLMCE RGANGHTRGS WRFAFNEQFT CLFDPENRKW TVVPPGGQWF KGTLDNDGEL TKLLIGTANG DCKSWLQHVW ERWDETQETT DRDIHPSMAN VPGRIMATEM VFLLFPFLRI IVFSMPPGV // ID M3YHL1_MUSPF Unreviewed; 322 AA. AC M3YHL1; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 38. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000010818}; OS Mustela putorius furo (European domestic ferret) (Mustela furo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; OC Mustelinae; Mustela. OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000010818, ECO:0000313|Proteomes:UP000000715}; RN [1] {ECO:0000313|Ensembl:ENSMPUP00000010818} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000010818}; RA Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S., RA Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., RA Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J., RA Walker B.J., Young S., Birren B., Lindblad-Toh K.; RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMPUP00000010818} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEYP01103970; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AEYP01103971; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_004781894.1; XM_004781837.2. DR ProteinModelPortal; M3YHL1; -. DR Ensembl; ENSMPUT00000010997; ENSMPUP00000010818; ENSMPUG00000010904. DR GeneID; 101679584; -. DR CTD; 563; -. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M3YHL1; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000000715; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000715}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000000715}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 322 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004044892. FT DOMAIN 207 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 322 AA; 36408 MW; B316CE7DBB9BFA0A CRC64; MDTIVSVLLS LLLLLGPAVP QETQAGPYSL SFFYTGLSRP RDGFPSFQAT AYLNDQDFFH YDSEDRKAIP QYPWSQMEGL EDWEKESELQ KAREKIFMAT LTDIMDYYKD KEGSHTFQGM FGCELRNDKN SGAFWRYAYD GRNFIEFNKE IPAWVPQDPA ALITKQKWEA EEVYVLRAKA YLEEECPAML RRFLQHGKTY LDRQDPPSVS ITSHGTPGET QTLKCRADGF YPREIELHWI HGGDTQETES GGDVLPSGNS TYQSWVVMSA SRQDGALDSY SCRVKHSSLA QPLTVLWPGA RADGSEGSQG QEPPHLLAGE TS // ID M3YJ13_MUSPF Unreviewed; 88 AA. AC M3YJ13; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 20-JUN-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000011320}; OS Mustela putorius furo (European domestic ferret) (Mustela furo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; OC Mustelinae; Mustela. OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000011320, ECO:0000313|Proteomes:UP000000715}; RN [1] {ECO:0000313|Ensembl:ENSMPUP00000011320} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000011320}; RA Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S., RA Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., RA Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J., RA Walker B.J., Young S., Birren B., Lindblad-Toh K.; RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMPUP00000011320} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEYP01101435; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AEYP01101436; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AEYP01101437; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3YJ13; -. DR Ensembl; ENSMPUT00000011508; ENSMPUP00000011320; ENSMPUG00000011412. DR InParanoid; M3YJ13; -. DR OrthoDB; EOG0907079Q; -. DR Proteomes; UP000000715; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000715}; KW Reference proteome {ECO:0000313|Proteomes:UP000000715}. FT DOMAIN 1 77 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 88 AA; 9928 MW; ABF854750FF28927 CRC64; MGSDGRLLGG YRHFANDSAD YLALNEDLRS WTAADAAAQI TRRKWEAAGV AEPQRNDLVV TCVEWLRRYL VMGNKTLHRT DVPKTHVT // ID M3YRC5_MUSPF Unreviewed; 357 AA. AC M3YRC5; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000013884}; OS Mustela putorius furo (European domestic ferret) (Mustela furo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; OC Mustelinae; Mustela. OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000013884, ECO:0000313|Proteomes:UP000000715}; RN [1] {ECO:0000313|Ensembl:ENSMPUP00000013884} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000013884}; RA Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S., RA Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., RA Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J., RA Walker B.J., Young S., Birren B., Lindblad-Toh K.; RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMPUP00000013884} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEYP01006387; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3YRC5; -. DR STRING; 9669.ENSMPUP00000013884; -. DR Ensembl; ENSMPUT00000014104; ENSMPUP00000013884; ENSMPUG00000013989. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR InParanoid; M3YRC5; -. DR OMA; MKNATQT; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000000715; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000715}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000715}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 357 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004045310. FT TRANSMEM 303 322 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 357 AA; 40004 MW; 427D89E93B4139AE CRC64; SLIPLTTCLV LLATAGVLAV EETWPGERGT GGISRPGRGE PQYWEVGYVD NTQFVRFDSA SGRMEPLVPW MEQEGPKYWD QQTQNARHHT QTFQMNLHTA LGYYNQSEAA GSHTLQGMFG CDLGPGGLLL HGYEQLAYDG VDYIALNEDL RSWPAADTVG QMTRRKWEAA GAAEHYRSYL EGTCMESLRK YLEKGKETLL RTEPPNTQMT QHPIFDKEVT LRCWALGFYP AEITPTWQRY GEDLTQNTEL VETRPAGDGN FQRWAAIVVP SGEEQKYMCH MQHEGLREPI TLRWDPPPPT IPITWIIAGL ALPVVIVWLE LIRTRELGLG SHGPAFSRLL NDDRGQGSGV SLMITGG // ID M3Z308_MUSPF Unreviewed; 229 AA. AC M3Z308; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 21. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000017970}; OS Mustela putorius furo (European domestic ferret) (Mustela furo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; OC Mustelinae; Mustela. OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000017970, ECO:0000313|Proteomes:UP000000715}; RN [1] {ECO:0000313|Ensembl:ENSMPUP00000017970} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000017970}; RA Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S., RA Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., RA Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J., RA Walker B.J., Young S., Birren B., Lindblad-Toh K.; RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMPUP00000017970} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AEYP01032481; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3Z308; -. DR Ensembl; ENSMPUT00000018232; ENSMPUP00000017970; ENSMPUG00000018081. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR InParanoid; M3Z308; -. DR OMA; WGKQLEM; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000000715; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000715}; KW Reference proteome {ECO:0000313|Proteomes:UP000000715}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 229 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004046036. FT DOMAIN 30 196 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 229 AA; 26044 MW; 558894F0A1FA188D CRC64; SCCAGTVLAL SCPILVLSPG WQRGACLDAL SLSYHFFITS QAKPGQPWCE VQGQINGKTF LSYDCQTKEF KPIGPWGMKL KDRSFWQQQE ETVKLLVEEL RKKLLDIKAE NFTKSGSLTM QGRLMCERGA DGHTRASWQF RFNESITYRF DPNNRKWTVD HSGGQQVKDM LDGDRELTML LVRTSNGDCQ SWLQQVWEHW DETQETTGLV TVAATNMVEG GHLGCRITW // ID M3ZCH8_NOMLE Unreviewed; 315 AA. AC M3ZCH8; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 25-APR-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000024415}; OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates OS leucogenys). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hylobatidae; Nomascus. OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000024415, ECO:0000313|Proteomes:UP000001073}; RN [1] {ECO:0000313|Ensembl:ENSNLEP00000024415} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Gibbon Genome Sequencing Consortium; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSNLEP00000024415} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADFV01069324; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01069325; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3ZCH8; -. DR Ensembl; ENSNLET00000032780; ENSNLEP00000024415; ENSNLEG00000026651. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M3ZCH8; -. DR OMA; WCKERRT; -. DR OrthoDB; EOG091G0ANY; -. DR Proteomes; UP000001073; Chromosome 1a. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001073}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001073}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 283 304 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 178 270 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 315 AA; 35744 MW; E69F5C3E862DD6C6 CRC64; PHSLRYNLTA LSRDGSVQSG FLAEGHLDGQ LFLHCDGQKC RTKPQGQWAE DVLGAETRDL TENGKNLRMT LAHLKDQKGG LHSLQEITVC EIHEDNSTRA FWHFYYDEEL FLSQNLETQE QTEPQSSRAQ ILAMNVTNFW KEDAMKTKTH YRAVQADCLQ KLQQYRKSGI VLRRTVPPMV IVTRSEASEG NITVTCWASG FYPWNITLTW RQDGVSLSHD AQQWGDVLRD ENGTYQTWVA TRIRQGEEQR FTCHVEHSGN HGTHPVPFFS GKVPVLQSQW TDIPFFSAVA AAAAIFVIIF YVLLCKKKTS AAEGP // ID M3ZFE0_XIPMA Unreviewed; 337 AA. AC M3ZFE0; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000000932}; OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Xiphophorus. OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000000932, ECO:0000313|Proteomes:UP000002852}; RN [1] {ECO:0000313|Ensembl:ENSXMAP00000000932} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000000932}; RA Walter R., Schartl M., Warren W.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSXMAP00000000932} RP IDENTIFICATION. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000000932}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGAJ01050710; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3ZFE0; -. DR STRING; 8083.ENSXMAP00000000932; -. DR Ensembl; ENSXMAT00000000935; ENSXMAP00000000932; ENSXMAG00000000946. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M3ZFE0; -. DR OMA; GYVDSHP; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000002852; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000002852}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002852}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 337 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004046177. FT TRANSMEM 301 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 201 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 159 179 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 337 AA; 38952 MW; 68EEAEEEE848EE04 CRC64; MMLIFLILVG IQGSTAVTHS LKYFYTASSG IENFPSYVSV GLVDEVQISY CDSRTNENIP KQDWMNKVNS KHPNYWEEET ETCWVKQRFL KGNLEIAKHR FNQTGGEHIY QQMYGCEWDD ETGEVKGYDE FGYDGEDLII LDSNTQQWIA PRTQAVITAN RWNNDRNDLE HENEYLTQTC VEWLRKYVNY GRRSLMRTDL PSVSLLQKSP SSPVSCFATG FYPNRAEMFW RKDGEEIHDG VEKGEIKPNN DGTFQMSVNI DLSSVATEDW NKYECVFQLS GVNDITNRLE KTRILTNESN IPIVIITFVL FVTVLGLIAV IGFILYNQKN NGEKWIF // ID M3ZH37_XIPMA Unreviewed; 310 AA. AC M3ZH37; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000001529}; OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Xiphophorus. OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000001529, ECO:0000313|Proteomes:UP000002852}; RN [1] {ECO:0000313|Ensembl:ENSXMAP00000001529} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000001529}; RA Walter R., Schartl M., Warren W.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSXMAP00000001529} RP IDENTIFICATION. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000001529}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGAJ01017515; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGAJ01017516; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGAJ01017517; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3ZH37; -. DR STRING; 8083.ENSXMAP00000001529; -. DR Ensembl; ENSXMAT00000001532; ENSXMAP00000001529; ENSXMAG00000001537. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M3ZH37; -. DR OMA; TENARWI; -. DR OrthoDB; EOG091G0BBK; -. DR Proteomes; UP000002852; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002852}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002852}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 292 309 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 192 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 310 AA; 35960 MW; 6A341807F6B2DDE5 CRC64; PLSVFHKPLF KLIPVLLFIL EKHSLSYIYT AFSNPVDLPG FHEFTAMGLL DNRMIDYYDS IDTSYLFSEN LPVCKIFYFL VFNYFFLLHF LTDTHILQWM HGCEGETQSD GTMQFVRGMD MYNYDGNDFL SFDDDRQVWV APIHAAEETK RKWDEVQVLK EYTKGYLEKE CMEWMSKFRD FGKEQLQRAT PPTVHLFTRK ANVETNTILT CLATGFYPKD IILHIKRNGR ILTKEDRVQT DGVLPNHDDT FQRRDYVEIL KSDVAKYTCE VKHPASSMHI ETSLEPKGEG NSLVIIAAII PILIVLGIGV // ID M3ZS42_XIPMA Unreviewed; 271 AA. AC M3ZS42; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000005035}; OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Xiphophorus. OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000005035, ECO:0000313|Proteomes:UP000002852}; RN [1] {ECO:0000313|Ensembl:ENSXMAP00000005035} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000005035}; RA Walter R., Schartl M., Warren W.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSXMAP00000005035} RP IDENTIFICATION. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000005035}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGAJ01044164; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGAJ01044165; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3ZS42; -. DR STRING; 8083.ENSXMAP00000005035; -. DR Ensembl; ENSXMAT00000005040; ENSXMAP00000005035; ENSXMAG00000005036. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M3ZS42; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000002852; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002852}; KW Reference proteome {ECO:0000313|Proteomes:UP000002852}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 271 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004046498. FT DOMAIN 202 271 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 271 AA; 31439 MW; F9FBD1BDD56125C6 CRC64; MTPLIFLILV GIQGSTAVTH SLKYFYTASS GIENFPSYVS VGLVDDVQIS YCDSKTNKNI PKQDWMDEVR SEHPDYWKEE TETCLVKQQT FKISLETAKQ RFNQTGGEHI YQQMYGCEWD NETGEVKVYD QFGYDGEDLI ILDSNTQEWI APRTQAVITA NKWNNDRYDL EHEKIYLTHI CVEWLKKYVN YGRSSLMRTV PPSVSFLQRF SSSPVSCFAT GFYPNKTEMF WRKDGEEIHD DVEKGEILPN NDGTFQMSIY LDLSSVPPED W // ID M3ZZH5_XIPMA Unreviewed; 216 AA. AC M3ZZH5; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 22. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000007619}; OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Xiphophorus. OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000007619, ECO:0000313|Proteomes:UP000002852}; RN [1] {ECO:0000313|Ensembl:ENSXMAP00000007619} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000007619}; RA Walter R., Schartl M., Warren W.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSXMAP00000007619} RP IDENTIFICATION. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000007619}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGAJ01047193; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M3ZZH5; -. DR STRING; 8083.ENSXMAP00000007619; -. DR Ensembl; ENSXMAT00000007627; ENSXMAP00000007619; ENSXMAG00000007599. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M3ZZH5; -. DR OMA; RETRICK; -. DR OrthoDB; EOG091G0BBK; -. DR Proteomes; UP000002852; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002852}; KW Reference proteome {ECO:0000313|Proteomes:UP000002852}. FT DOMAIN 29 212 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 216 AA; 25820 MW; 3EC5514369472CFE CRC64; TGITINSGKC FFFFFFFFCT LTISSFLEKH TLTYIYTAFS KPVNLPGLHE FTAMGLLDNS MIDYYDSENQ IKVPKQEWMK EHLEQEYWEK GTQSRKSKQQ WFKVNIDILM KRMRQNDTNT HILQWMHGCE GETQPDGTMQ FVRGMDMYNY DGNDFLSFDD DRQVWVAPIH AAEETKRKWD EVQVLKEYTK GYLEKECMEW MSKFRDFGKE QLLKAS // ID M4A4R2_XIPMA Unreviewed; 175 AA. AC M4A4R2; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 23-MAY-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000009456}; OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Xiphophorus. OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000009456, ECO:0000313|Proteomes:UP000002852}; RN [1] {ECO:0000313|Ensembl:ENSXMAP00000009456} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000009456}; RA Walter R., Schartl M., Warren W.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSXMAP00000009456} RP IDENTIFICATION. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000009456}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGAJ01045420; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_014330990.1; XM_014475504.1. DR ProteinModelPortal; M4A4R2; -. DR Ensembl; ENSXMAT00000009470; ENSXMAP00000009456; ENSXMAG00000009441. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M4A4R2; -. DR OMA; RRSHITH; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000002852; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002852}; KW Reference proteome {ECO:0000313|Proteomes:UP000002852}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 175 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004047511. FT DOMAIN 19 172 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 175 AA; 20147 MW; D460CFEBDECD468A CRC64; MTPLIFLILV GIQGSTAVTH SLKYFYTASS GIENFPSYVS VGLVDEVQIS YCDSRTNENI PKQDWMNELS SEHPDYWKEE TETCLAKQQT FKANLEIAKQ RFNQTEGVHV FQQMYGCEWD EETGEVKGYD QFGYDGEDLI TLDPKTQEWI APKPQAVITK HKWDNNRAAV EHEKI // ID M4AII9_XIPMA Unreviewed; 127 AA. AC M4AII9; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000014283}; OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Xiphophorus. OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000014283, ECO:0000313|Proteomes:UP000002852}; RN [1] {ECO:0000313|Ensembl:ENSXMAP00000014283} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014283}; RA Walter R., Schartl M., Warren W.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSXMAP00000014283} RP IDENTIFICATION. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014283}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGAJ01024074; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M4AII9; -. DR Ensembl; ENSXMAT00000014303; ENSXMAP00000014283; ENSXMAG00000014268. DR GeneTree; ENSGT00910000145975; -. DR InParanoid; M4AII9; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000002852; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002852}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002852}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 6 24 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 25 125 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 127 AA; 14844 MW; 4FD3F667EF6C9335 CRC64; EKRDQIAIMN YFGLLLLFHV ASSVKHSLRY FLTATYGVED FPEFVGAATV DEFQVGYCDS NIKTAKPKQD WMRKLIERNP EHLEWYSQKC LGSQHVFRAN IDDLKQRLNL TEGPYILQVL YGCYVLF // ID M4AIJ2_XIPMA Unreviewed; 264 AA. AC M4AIJ2; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 22. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000014286}; OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Xiphophorus. OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000014286, ECO:0000313|Proteomes:UP000002852}; RN [1] {ECO:0000313|Ensembl:ENSXMAP00000014286} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014286}; RA Walter R., Schartl M., Warren W.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSXMAP00000014286} RP IDENTIFICATION. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014286}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGAJ01024080; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M4AIJ2; -. DR Ensembl; ENSXMAT00000014306; ENSXMAP00000014286; ENSXMAG00000014269. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M4AIJ2; -. DR OMA; FLMRTGN; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000002852; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002852}; KW Reference proteome {ECO:0000313|Proteomes:UP000002852}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 264 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004047599. FT DOMAIN 93 196 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 264 AA; 30912 MW; 470881DA783E9EFB CRC64; MWNKMIKFLL TLLFCLLSSA EKHFLKFYYS GSSGLPHSSQ SEVVAEIDGS LIAYCNQTEF KIHDWVKKGL DDDVELLTFF KMMCSHTLPN TIQARISDLK QRFKEPEGVH VFQWIDSCGW DTETGELTGF LQYGYNGEDF IALDFKRLSW IALKQQAIPT KLAWDTDRAR LDYNKIFFSQ LCPGWLKRSL DYGRNFLMRT GNVTRSSFKL YHRVMLSLCT SFTLGSFWVH WVFAQLPKHE QTFVIYFLLS NLSICETEYK NMKL // ID M4AIJ3_XIPMA Unreviewed; 338 AA. AC M4AIJ3; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000014287}; OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Xiphophorus. OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000014287, ECO:0000313|Proteomes:UP000002852}; RN [1] {ECO:0000313|Ensembl:ENSXMAP00000014287} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014287}; RA Walter R., Schartl M., Warren W.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSXMAP00000014287} RP IDENTIFICATION. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014287}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGAJ01024080; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M4AIJ3; -. DR Ensembl; ENSXMAT00000014307; ENSXMAP00000014287; ENSXMAG00000014271. DR eggNOG; ENOG410INYR; Eukaryota. DR eggNOG; ENOG4110Q3N; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M4AIJ3; -. DR OMA; DWARYDC; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000002852; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002852}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002852}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 338 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004047705. FT TRANSMEM 306 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 274 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 338 AA; 39221 MW; 7A21FDD0023D2382 CRC64; MKWFVILLMF SHSSSAESHF LKIYFTGSSG FTNVPAFEIL GKLDDIEGAY CNNKIVDSKI DFVKKLFSDD PKLFEFIKSS CFITNPAFFR HMIAELMKKF NQSEGIHTFQ RMGGCELNME TKEVTGFLKY GYDGEDFLEF DLKGLKWIAL RKEALFLKQL WEMDRQDLIF NRDLLTNRCY QALNYSLVAG HNYLFRTDYP SVSLLQKTPS SPVRCHATGF YPKSFLMFWR KDGEEIHEGV DPGDILNNED STFQYRVDLD ISSIPYMDWA RYDCVFQFTG AEDKILIKLD KEVIKTNRDQ SSEIRIIIIV VISAVITIII IALAFTAYKR NDSENTFL // ID M4AJ95_XIPMA Unreviewed; 194 AA. AC M4AJ95; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 22. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000014539}; OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Xiphophorus. OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000014539, ECO:0000313|Proteomes:UP000002852}; RN [1] {ECO:0000313|Ensembl:ENSXMAP00000014539} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014539}; RA Walter R., Schartl M., Warren W.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSXMAP00000014539} RP IDENTIFICATION. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014539}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGAJ01052725; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M4AJ95; -. DR STRING; 8083.ENSXMAP00000014539; -. DR Ensembl; ENSXMAT00000014559; ENSXMAP00000014539; ENSXMAG00000014517. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M4AJ95; -. DR OMA; DQANRED; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000002852; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002852}; KW Reference proteome {ECO:0000313|Proteomes:UP000002852}. FT DOMAIN 36 193 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 194 AA; 22452 MW; C24D90807FEAB8D8 CRC64; MLTPTELIRC QVFSILGQAS SCYTKIFRKV FFLTVTHSLK YFYTASSGIE NPSYVSVGLV DDVQISYCDN NINKNIPKQD WMNKVNSEHP NYWKEETETC LAKQRTFKFS LKIAKQRFNQ TGGVHVFQQM YGCEWDDETG EVKGYDQFGS DGEDLIMLDP QTQQWIAPKP QAVITANRFN NSRIIKELEK IYLT // ID M4AJN4_XIPMA Unreviewed; 178 AA. AC M4AJN4; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000014678}; OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Xiphophorus. OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000014678, ECO:0000313|Proteomes:UP000002852}; RN [1] {ECO:0000313|Ensembl:ENSXMAP00000014678} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014678}; RA Walter R., Schartl M., Warren W.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSXMAP00000014678} RP IDENTIFICATION. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014678}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGAJ01024098; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGAJ01024099; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGAJ01024100; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M4AJN4; -. DR STRING; 8083.ENSXMAP00000014678; -. DR Ensembl; ENSXMAT00000014698; ENSXMAP00000014678; ENSXMAG00000014655. DR eggNOG; ENOG410IUPG; Eukaryota. DR eggNOG; ENOG4110PXI; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M4AJN4; -. DR OMA; DWINTYM; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000002852; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002852}; KW Reference proteome {ECO:0000313|Proteomes:UP000002852}. FT DOMAIN 135 178 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 178 AA; 20888 MW; C93A30F0A6549083 CRC64; MRDNMDQQYW ERQTGNLQGT QQSFKANIET AKQRFNQTGG IHVFQFMYGC EWDEETKAKK GFWQFGYDGE DFVAFDLSSK KWTAPTPQAV ITKNKWDNDR GWITQADTYL NQECPDWINT YMNYGKTSLM RTEKPSVSFL QKSSSSPVRC HATGFYPNKA ELFWRKDGEE IHEAVRCQ // ID M4AJN7_XIPMA Unreviewed; 126 AA. AC M4AJN7; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000014681}; OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Xiphophorus. OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000014681, ECO:0000313|Proteomes:UP000002852}; RN [1] {ECO:0000313|Ensembl:ENSXMAP00000014681} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014681}; RA Walter R., Schartl M., Warren W.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSXMAP00000014681} RP IDENTIFICATION. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014681}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGAJ01024104; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGAJ01024105; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M4AJN7; -. DR STRING; 8083.ENSXMAP00000014681; -. DR Ensembl; ENSXMAT00000014701; ENSXMAP00000014681; ENSXMAG00000014656. DR GeneTree; ENSGT00900000141162; -. DR InParanoid; M4AJN7; -. DR OMA; WDSETEI; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000002852; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002852}; KW Reference proteome {ECO:0000313|Proteomes:UP000002852}. FT DOMAIN 26 123 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 126 AA; 14420 MW; 7136681B9103C9B6 CRC64; VDVLTDKMTN FVLLLILGIH TTAAVTHSLK YFYTASTQVP GFPEFVVVAL VDDVQIAYYD SVIKRAEPKQ DWMREITDQQ YWERETGNFL GNQQIFKANI EILKQRFNQT GGVHVVQLLS GVERDV // ID M4AJN8_XIPMA Unreviewed; 252 AA. AC M4AJN8; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000014682}; OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Xiphophorus. OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000014682, ECO:0000313|Proteomes:UP000002852}; RN [1] {ECO:0000313|Ensembl:ENSXMAP00000014682} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014682}; RA Walter R., Schartl M., Warren W.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSXMAP00000014682} RP IDENTIFICATION. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014682}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGAJ01024106; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGAJ01024107; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGAJ01024108; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGAJ01024109; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M4AJN8; -. DR STRING; 8083.ENSXMAP00000014682; -. DR Ensembl; ENSXMAT00000014702; ENSXMAP00000014682; ENSXMAG00000014659. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M4AJN8; -. DR OMA; RKWEALG; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000002852; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002852}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002852}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 204 228 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 104 176 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 252 AA; 28486 MW; 751D81387EB0ABCF CRC64; MATFNQTGGI HLFQRMYGCE WDEETGEIKG FNQFGYDGED FVAFDLKSGS WIAPTPEAVV TKHKWDNNKG LNANQLNYYN QECPEWIKKY VNYGRSFLMR TVPPSVSLLQ KSSSSPVSCL ATGFYPNKAE ILWRKDGVEI HDGVEKREIL SNNDGTFQTS AELKLSTSED WTKYDCVFQL SGFDKDLVTP LDKANIKTNE GNSLVIILTI VAVVVFITCT AVIIIVLFKR KNAKRPPSPV EYAEVQEIMM PK // ID M4AQ75_XIPMA Unreviewed; 223 AA. AC M4AQ75; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000016620}; OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Xiphophorus. OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000016620, ECO:0000313|Proteomes:UP000002852}; RN [1] {ECO:0000313|Ensembl:ENSXMAP00000016620} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000016620}; RA Walter R., Schartl M., Warren W.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSXMAP00000016620} RP IDENTIFICATION. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000016620}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGAJ01047226; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M4AQ75; -. DR Ensembl; ENSXMAT00000016645; ENSXMAP00000016620; ENSXMAG00000016595. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M4AQ75; -. DR OMA; FCHAISA; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000002852; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002852}; KW Reference proteome {ECO:0000313|Proteomes:UP000002852}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 15 {ECO:0000256|SAM:SignalP}. FT CHAIN 16 223 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013130570. FT DOMAIN 17 191 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 223 AA; 25611 MW; 15644E8CD6DB5F9E CRC64; MKCLVILMFC HAISAESHFL KIYFTGSSGF TNVPAFEIVG KLDDIEGAYC NNKIVDSKID FVKKLFSDDP KLFEFIKSSC FLTNPAFFRH MIAELMKKFN QSEGIHTFQR IGGCELNMET IEVTGFLKYG YDGEDFLEFD LKGLKWIALR KEALFLKQLW EMDRQDLIYN RDLLTNRCYQ ALNYSLVAGH NYLFRTGTVL QMTGCTGSTS TLICLSLSFK SYL // ID M4AQ79_XIPMA Unreviewed; 257 AA. AC M4AQ79; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000016624}; OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Xiphophorus. OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000016624, ECO:0000313|Proteomes:UP000002852}; RN [1] {ECO:0000313|Ensembl:ENSXMAP00000016624} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000016624}; RA Walter R., Schartl M., Warren W.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSXMAP00000016624} RP IDENTIFICATION. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000016624}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGAJ01047228; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M4AQ79; -. DR Ensembl; ENSXMAT00000016648; ENSXMAP00000016624; ENSXMAG00000016596. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M4AQ79; -. DR OMA; NCQHNFE; -. DR OrthoDB; EOG091G0BU8; -. DR Proteomes; UP000002852; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002852}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002852}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 204 225 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 69 172 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 257 AA; 28959 MW; E1D9C05675D28AD4 CRC64; MIGCELDEKS AEVVTFQQCG YNGEDFMKLY SKNMTWTAQH PLAEKLKPLW DSAQEGLNNI TLFLTLICPQ MLEKFVTLSA LQREDLTSVA LLQKTPSSPV NCFATGFYPN AARMFWMRDG MEIQNDKEPS EILPNHDNTY QMSVYLNVSS IASDDWKRYD CVFRLGNKTK LTRLEKAAIS TNWVLDPVPP STSPSPSSKF PLDLATGLVV GLILLCFCIT GLFLWKNVNS ASKFPDPSSY PTYPGTIQNC QHNFEIQ // ID M4AQY8_XIPMA Unreviewed; 168 AA. AC M4AQY8; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 22. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000016883}; OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Xiphophorus. OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000016883, ECO:0000313|Proteomes:UP000002852}; RN [1] {ECO:0000313|Ensembl:ENSXMAP00000016883} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000016883}; RA Walter R., Schartl M., Warren W.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSXMAP00000016883} RP IDENTIFICATION. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000016883}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGAJ01013886; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M4AQY8; -. DR STRING; 8083.ENSXMAP00000016883; -. DR Ensembl; ENSXMAT00000016907; ENSXMAP00000016883; ENSXMAG00000016854. DR GeneTree; ENSGT00740000114936; -. DR InParanoid; M4AQY8; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000002852; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002852}; KW Reference proteome {ECO:0000313|Proteomes:UP000002852}. FT DOMAIN 3 147 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 168 AA; 20141 MW; D5C7E29341DA505C CRC64; MYYDSNIREA KPKQDWMKKV TEDDPQYWDF QTRELFGTLM SFINSIEVAK KRFNQTGGVH IFQNMYGCEF DDEYKEVEGW ENFGYDGEDF IALDLKTERW SAPVYQASIT KNKWDNDKRK MAETKYYITQ TCPDWLEKYL EYGKNSLKRT GRTTNCLVFC TLCPYLNF // ID M4AQZ0_XIPMA Unreviewed; 340 AA. AC M4AQZ0; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 20-JUN-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000016885}; OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Xiphophorus. OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000016885, ECO:0000313|Proteomes:UP000002852}; RN [1] {ECO:0000313|Ensembl:ENSXMAP00000016885} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000016885}; RA Walter R., Schartl M., Warren W.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSXMAP00000016885} RP IDENTIFICATION. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000016885}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGAJ01013887; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGAJ01013888; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M4AQZ0; -. DR Ensembl; ENSXMAT00000016909; ENSXMAP00000016885; ENSXMAG00000016857. DR GeneTree; ENSGT00900000141162; -. DR InParanoid; M4AQZ0; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000002852; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 2. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002852}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002852}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 340 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004048046. FT TRANSMEM 310 336 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 21 116 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 340 AA; 39377 MW; 5E7C3495F859AF5D CRC64; LQMLVFVLLF LLDLPNVVAV THSLKYFYTA SSGIENFPSY VSVGLVDEVQ ISYCDSRTNE NIPKQDWMDE VSSEHPNYWK EETETCLAKQ RTFKINLEIA KQRYSQSGVK HFFQALNSQR FPNRSLQIIM FLCFMNQFVT IKYTFRVFRV PIFQLFIKKQ AQNSDLLLLW TKKNLLIKLS GYIEILVDPT TMSQLSSDLP SVSLLQKNSS SAVCCHFSGF KDNIVTRLER KKIRTNEGED KSELLINVDG NEVMYYDSNI REAKPKQDWM KFVCCHQLFG LKDDLVIQLE KTQIRSNYGE NKMRSESTGY SYVLIISLIV VVILCLATLA LSGYVYTLRK // ID M7ANM8_CHEMY Unreviewed; 437 AA. AC M7ANM8; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 22-NOV-2017, entry version 27. DE SubName: Full=Major histocompatibility complex class I-related gene protein {ECO:0000313|EMBL:EMP26826.1}; GN ORFNames=UY3_16095 {ECO:0000313|EMBL:EMP26826.1}; OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia; OC Chelonioidea; Cheloniidae; Chelonia. OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP26826.1, ECO:0000313|Proteomes:UP000031443}; RN [1] {ECO:0000313|Proteomes:UP000031443} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23624526; DOI=10.1038/ng.2615; RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., RA Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., RA Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., RA Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J., RA Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G., RA Irie N.; RT "The draft genomes of soft-shell turtle and green sea turtle yield RT insights into the development and evolution of the turtle-specific RT body plan."; RL Nat. Genet. 45:701-706(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB575999; EMP26826.1; -; Genomic_DNA. DR ProteinModelPortal; M7ANM8; -. DR Proteomes; UP000031443; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000031443}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000031443}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT DOMAIN 245 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 437 AA; 49067 MW; D2142835821ED6C0 CRC64; MGFYPCPITV TWEQRDQVTL GKQLTSGIQL NGDRTFQIQV SIEQGQEGVS PAEHVFVVRH SSLGDAPLRV TWGVHHLSHL QLISPWAAPG LPKLLHVMMV DDLVRSTYDS NTRRLAPRSG YNPANQEFWS AGNAACMAWD SWVETKYQAL VQEVNASSPQ AEPYHMQILK TCELDDATGA VRAVTRYSLN GEDVLRYQSD QNRWFSEHPA AWRVAERWNR EGETFTVWNL IQPQHCRFFI ELTLPFIAQK TAQPSVRVAL VPGTQDRPRC LVCHVTGFYP RDIEVIWERG GQVVHGEQLT SGILPNGDLT FQIQVSIELG QEGVGPAEHV CVAYRPVHGS LVPRKDSLGT DIFRNDNGDC IVHSDLGCYL QMELLENIKI QRLHPLCQGG DDYLGCVEDP NIYIIKGSSY RVVKDLSMDE EAKVYELHPS CCGGDTT // ID M7ASN6_CHEMY Unreviewed; 276 AA. AC M7ASN6; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 25-OCT-2017, entry version 16. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain {ECO:0000313|EMBL:EMP25910.1}; GN ORFNames=UY3_17009 {ECO:0000313|EMBL:EMP25910.1}; OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia; OC Chelonioidea; Cheloniidae; Chelonia. OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP25910.1, ECO:0000313|Proteomes:UP000031443}; RN [1] {ECO:0000313|Proteomes:UP000031443} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23624526; DOI=10.1038/ng.2615; RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., RA Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., RA Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., RA Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J., RA Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G., RA Irie N.; RT "The draft genomes of soft-shell turtle and green sea turtle yield RT insights into the development and evolution of the turtle-specific RT body plan."; RL Nat. Genet. 45:701-706(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB585327; EMP25910.1; -; Genomic_DNA. DR ProteinModelPortal; M7ASN6; -. DR Proteomes; UP000031443; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000031443}; KW Reference proteome {ECO:0000313|Proteomes:UP000031443}. FT DOMAIN 135 273 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 276 AA; 31198 MW; 9665D00579345BDD CRC64; MMERGHDRDT LECRVKVKEL RNAYLKEREA NCRSVAVPTS CRYYTELDMI LGGDPTSTTE TTVDTSVAQG TIESGLNQKE EIVDGDMEGE GDPETEDDFV FTDACSQELF STQEEASQSQ QSEFGKAETG QEAPGRHSLN ILVTGVIDEE GTNQYFMIAK LDDVKIAYYS SDTREVRTTQ EWVAQAVGSD YLREKTQKFW RYEEGSKGHT RWWMQLHNQT GGFHTEQVHV GCALSGQALV DPRFQYAYDG RDFISFDDQT GTWVAAEQPA FPQKQS // ID M7BRX6_CHEMY Unreviewed; 290 AA. AC M7BRX6; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 28-FEB-2018, entry version 27. DE SubName: Full=Major histocompatibility complex class I-related gene protein {ECO:0000313|EMBL:EMP39964.1}; GN ORFNames=UY3_02803 {ECO:0000313|EMBL:EMP39964.1}; OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia; OC Chelonioidea; Cheloniidae; Chelonia. OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP39964.1, ECO:0000313|Proteomes:UP000031443}; RN [1] {ECO:0000313|Proteomes:UP000031443} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23624526; DOI=10.1038/ng.2615; RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., RA Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., RA Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., RA Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J., RA Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G., RA Irie N.; RT "The draft genomes of soft-shell turtle and green sea turtle yield RT insights into the development and evolution of the turtle-specific RT body plan."; RL Nat. Genet. 45:701-706(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB515207; EMP39964.1; -; Genomic_DNA. DR ProteinModelPortal; M7BRX6; -. DR Proteomes; UP000031443; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000031443}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000031443}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 173 197 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 77 164 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 290 AA; 31331 MW; 022DC617B61113F9 CRC64; MGSTRGKYSG SGARVQTPLP GNGRVQHISK NRSYRKKWDA ERSFAQRQRA YLEGTCIEWL GKYLEYGKET LQRREPPRVQ VSDRPSQDAG LTTLSCRVHG FYPRNVAVVW LKKGVAMQQE TNRGDVVPSG DGTYQTRATI DIDPSSETDY TCCVEHPSLT EDLRVPWKPK SNVMLIVGAV IGVLVLVAAV AGAVVFLRKK KGDYKAAPGS NQGSNICVKG TPDAGALSLL FPAGWNQLVR REGLSDMPAA SVRPSDCLPA CGPLPGISSA LPAGNEPTGP GAERQQLLLL // ID M7BUM4_CHEMY Unreviewed; 147 AA. AC M7BUM4; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 25-OCT-2017, entry version 16. DE SubName: Full=H-2 class I histocompatibility antigen, Q9 alpha chain {ECO:0000313|EMBL:EMP40884.1}; GN ORFNames=UY3_01879 {ECO:0000313|EMBL:EMP40884.1}; OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia; OC Chelonioidea; Cheloniidae; Chelonia. OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP40884.1, ECO:0000313|Proteomes:UP000031443}; RN [1] {ECO:0000313|Proteomes:UP000031443} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23624526; DOI=10.1038/ng.2615; RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., RA Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., RA Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., RA Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J., RA Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G., RA Irie N.; RT "The draft genomes of soft-shell turtle and green sea turtle yield RT insights into the development and evolution of the turtle-specific RT body plan."; RL Nat. Genet. 45:701-706(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB501958; EMP40884.1; -; Genomic_DNA. DR ProteinModelPortal; M7BUM4; -. DR Proteomes; UP000031443; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000031443}; KW Reference proteome {ECO:0000313|Proteomes:UP000031443}. FT DOMAIN 26 116 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 147 AA; 16262 MW; 5F01DBC89D86E8D4 CRC64; MVGDSQTAAG GVPCWRRCSR ALGRAGSHSL QYFLTAVSEP GPGVPDFTVA GYVDGQRFVE YDGEAQQMRP LAPWMQAAQP EVWEQENRVH KVRQACFRGK VRSHLHLYNQ SRGSRVFRCG HSKRPEPSPG PVVRDNHIGP PAPARTS // ID M7BVR8_CHEMY Unreviewed; 261 AA. AC M7BVR8; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 25-OCT-2017, entry version 16. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain {ECO:0000313|EMBL:EMP41294.1}; GN ORFNames=UY3_01462 {ECO:0000313|EMBL:EMP41294.1}; OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia; OC Chelonioidea; Cheloniidae; Chelonia. OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP41294.1, ECO:0000313|Proteomes:UP000031443}; RN [1] {ECO:0000313|Proteomes:UP000031443} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23624526; DOI=10.1038/ng.2615; RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., RA Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., RA Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., RA Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J., RA Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G., RA Irie N.; RT "The draft genomes of soft-shell turtle and green sea turtle yield RT insights into the development and evolution of the turtle-specific RT body plan."; RL Nat. Genet. 45:701-706(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB494738; EMP41294.1; -; Genomic_DNA. DR ProteinModelPortal; M7BVR8; -. DR Proteomes; UP000031443; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000031443}; KW Reference proteome {ECO:0000313|Proteomes:UP000031443}. FT DOMAIN 47 222 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 261 AA; 28864 MW; 6DC914484D2EB3EE CRC64; MRQPFITVPA PVLPPACGAE RLLQLRTPIS PSNLVSLLAQ VGPTGPGHHS LAVLVTAVTH EDGTHHFTMI TKVDDVQIAY YRSDTREVRP TQEWVAQAVG AEYLQEKTQQ FWGHEEFSKG DIRRWMQLYN QTGGIHTEQV HVGCALSDQA PMDPRFQFAY NGRDFISFDN QTGTWVAAVQ PAFAPKQRWE TTGKAWTKFV QQYLQSECLG TLRSLVLQGR AVLEQQGPRK PSYALAATKS GEDSASSSSL GTDPRSVGPQ S // ID M7BX20_CHEMY Unreviewed; 276 AA. AC M7BX20; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 25-OCT-2017, entry version 25. DE SubName: Full=Major histocompatibility complex class I-related gene protein {ECO:0000313|EMBL:EMP42381.1}; GN ORFNames=UY3_00351 {ECO:0000313|EMBL:EMP42381.1}; OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia; OC Chelonioidea; Cheloniidae; Chelonia. OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP42381.1, ECO:0000313|Proteomes:UP000031443}; RN [1] {ECO:0000313|Proteomes:UP000031443} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23624526; DOI=10.1038/ng.2615; RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., RA Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., RA Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., RA Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J., RA Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G., RA Irie N.; RT "The draft genomes of soft-shell turtle and green sea turtle yield RT insights into the development and evolution of the turtle-specific RT body plan."; RL Nat. Genet. 45:701-706(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB474190; EMP42381.1; -; Genomic_DNA. DR ProteinModelPortal; M7BX20; -. DR Proteomes; UP000031443; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000031443}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000031443}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 229 252 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 134 222 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 276 AA; 31688 MW; 78381AABC9824268 CRC64; MARNVDPQHW DEQTWRARRW QAWFNASLNT LRELYNHNKG FHVIQTIYGC DLREDNVIQG FYQDSYDGRD FLTFDKETMT WVAADIGAQI TKKRWDVEIG DNQRWKRYLE EECIPWLRSS LEYGKETLQR KVRPTARVSD RSSHDGLTTL SCTVRGFYPR DITVTWLKNG ESRQQETYSE GILPSGDGTY QTWVKMEIDP KIKAHYSCHV EHESLLEPLS VSWEPNNNLI PVVAGVITAV VLIGVIIGVV IWKTKRPGKE PGMGGFPGLA GPCTPA // ID M7BZ45_CHEMY Unreviewed; 197 AA. AC M7BZ45; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 25-OCT-2017, entry version 17. DE SubName: Full=Major histocompatibility complex class I-related gene protein {ECO:0000313|EMBL:EMP42499.1}; DE Flags: Fragment; GN ORFNames=UY3_00232 {ECO:0000313|EMBL:EMP42499.1}; OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia; OC Chelonioidea; Cheloniidae; Chelonia. OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP42499.1, ECO:0000313|Proteomes:UP000031443}; RN [1] {ECO:0000313|Proteomes:UP000031443} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23624526; DOI=10.1038/ng.2615; RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., RA Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., RA Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., RA Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J., RA Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G., RA Irie N.; RT "The draft genomes of soft-shell turtle and green sea turtle yield RT insights into the development and evolution of the turtle-specific RT body plan."; RL Nat. Genet. 45:701-706(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB471856; EMP42499.1; -; Genomic_DNA. DR ProteinModelPortal; M7BZ45; -. DR Proteomes; UP000031443; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000031443}; KW Reference proteome {ECO:0000313|Proteomes:UP000031443}. FT DOMAIN 1 174 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:EMP42499.1}. SQ SEQUENCE 197 AA; 22292 MW; 8F0491FAE827791C CRC64; HSLDVLITGL NELGGTHRFF MLAKLDGLEL ASYSSDTREL KPLKEWAVQA VGVRYLRKKT EEFRLYEAIS RVVTHRWMAQ HNQTGGIHTL QLHVNCVLDG DTPVRGHFRF AFDGQDFLVL ERNQSTWVPL APGALNETLY WDAGHSWTLF AKEFLQEECV ATLRSLLRGG TEALGRKGES EQPAARAGGN RRLMMEL // ID M7C576_CHEMY Unreviewed; 155 AA. AC M7C576; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 25-OCT-2017, entry version 16. DE SubName: Full=Saoe class I histocompatibility antigen, C alpha chain {ECO:0000313|EMBL:EMP39633.1}; GN ORFNames=UY3_03144 {ECO:0000313|EMBL:EMP39633.1}; OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia; OC Chelonioidea; Cheloniidae; Chelonia. OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP39633.1, ECO:0000313|Proteomes:UP000031443}; RN [1] {ECO:0000313|Proteomes:UP000031443} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23624526; DOI=10.1038/ng.2615; RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., RA Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., RA Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., RA Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J., RA Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G., RA Irie N.; RT "The draft genomes of soft-shell turtle and green sea turtle yield RT insights into the development and evolution of the turtle-specific RT body plan."; RL Nat. Genet. 45:701-706(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB516163; EMP39633.1; -; Genomic_DNA. DR ProteinModelPortal; M7C576; -. DR Proteomes; UP000031443; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000031443}; KW Reference proteome {ECO:0000313|Proteomes:UP000031443}. FT DOMAIN 3 128 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 155 AA; 18339 MW; C6B44F7F9204F905 CRC64; MAQNEGPELW ELRTFWARRW EAWFRISLNA LSQLYNRTEG FHIIQTLFGC DLREDNTTQV FYQDSYDGRD FLTFDKETMT WVAADIGAQI TKRRWHAEVD DNQGWKYYLE KICTEFLRQE IEYGKETLQK KVGLVLVKSG PDPKPVEANG MFPLT // ID M7C8G7_CHEMY Unreviewed; 199 AA. AC M7C8G7; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 25-OCT-2017, entry version 16. DE SubName: Full=HLA class I histocompatibility antigen, A-11 alpha chain {ECO:0000313|EMBL:EMP40883.1}; GN ORFNames=UY3_01878 {ECO:0000313|EMBL:EMP40883.1}; OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia; OC Chelonioidea; Cheloniidae; Chelonia. OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP40883.1, ECO:0000313|Proteomes:UP000031443}; RN [1] {ECO:0000313|Proteomes:UP000031443} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23624526; DOI=10.1038/ng.2615; RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., RA Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., RA Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., RA Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J., RA Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G., RA Irie N.; RT "The draft genomes of soft-shell turtle and green sea turtle yield RT insights into the development and evolution of the turtle-specific RT body plan."; RL Nat. Genet. 45:701-706(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB501958; EMP40883.1; -; Genomic_DNA. DR ProteinModelPortal; M7C8G7; -. DR Proteomes; UP000031443; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000031443}; KW Reference proteome {ECO:0000313|Proteomes:UP000031443}. FT DOMAIN 35 106 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 199 AA; 21564 MW; 45DF46C5BA002300 CRC64; MERYNQSRVA TQVTRPRVPR GLGRGGSEGA GPRVRSNDFR QCGYDGRDFL SYDPRTHTWV ASSKEAEITK GKMEADSHLS QQQRDYLERK CVEWLQKYLE WGKEMLQRRA GNQDSSSSLE AGNQDSSSSL EAGNQDSSSS LEASDKESSK GSTRGSEAVM QLVGDTGGGE TSHPPEAQQL LPGGVSALPD DGDPPAGIV // ID M7CCP3_CHEMY Unreviewed; 257 AA. AC M7CCP3; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 25-OCT-2017, entry version 24. DE SubName: Full=Antigen-presenting glycoprotein CD1d {ECO:0000313|EMBL:EMP42488.1}; GN ORFNames=UY3_00240 {ECO:0000313|EMBL:EMP42488.1}; OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia; OC Chelonioidea; Cheloniidae; Chelonia. OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP42488.1, ECO:0000313|Proteomes:UP000031443}; RN [1] {ECO:0000313|Proteomes:UP000031443} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23624526; DOI=10.1038/ng.2615; RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., RA Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., RA Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., RA Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J., RA Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G., RA Irie N.; RT "The draft genomes of soft-shell turtle and green sea turtle yield RT insights into the development and evolution of the turtle-specific RT body plan."; RL Nat. Genet. 45:701-706(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB471968; EMP42488.1; -; Genomic_DNA. DR Proteomes; UP000031443; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000031443}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000031443}. FT DOMAIN 105 191 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 257 AA; 27258 MW; 4FC7DC8CC18C653E CRC64; MGREVRGLDP FVTQVSVSCE FHPNGTSRGF YEAAVNGEDF ISFDADAGTW VARQGDKLAL YTRDLLNHER STAITLQFLL RATCINELKS FVQYGNESLE RQGRPVAVVF ARAPPPAGIP APLLLVCRVT GFYPRPIRVA WLPDGEEVGP GWRLNSSGIL PNADLTYQLR SSLAVGPGDG HSYACRVEHS SLGGQSLLIP WGRGTSPGLG VRSWSLGLFL HVLSGTGVGP GSGIGAQGGR GVSEGWGDGP GGAGWRS // ID M7CML8_CHEMY Unreviewed; 401 AA. AC M7CML8; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 25-OCT-2017, entry version 16. DE SubName: Full=Antigen-presenting glycoprotein CD1d {ECO:0000313|EMBL:EMP42487.1}; DE Flags: Fragment; GN ORFNames=UY3_00239 {ECO:0000313|EMBL:EMP42487.1}; OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia; OC Chelonioidea; Cheloniidae; Chelonia. OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP42487.1, ECO:0000313|Proteomes:UP000031443}; RN [1] {ECO:0000313|Proteomes:UP000031443} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23624526; DOI=10.1038/ng.2615; RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., RA Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., RA Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., RA Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J., RA Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G., RA Irie N.; RT "The draft genomes of soft-shell turtle and green sea turtle yield RT insights into the development and evolution of the turtle-specific RT body plan."; RL Nat. Genet. 45:701-706(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB471968; EMP42487.1; -; Genomic_DNA. DR Proteomes; UP000031443; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF16497; MHC_I_3; 1. DR SUPFAM; SSF54452; SSF54452; 2. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000031443}; KW Reference proteome {ECO:0000313|Proteomes:UP000031443}. FT DOMAIN 2 134 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF16497}. FT DOMAIN 303 395 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:EMP42487.1}. SQ SEQUENCE 401 AA; 43341 MW; 3B9088EFD429FB65 CRC64; QIRFLQPWAQ RGLTPKQWQD VELLIHRSLS SFIRLMNKAV KDAGEGYPFV PQFSPGCELH PNGSSTQYCD AGMNGEDFIS FDAGAGTWLA RQGDKLALEV WDLLSQDRGT TAMLQSLLRT TGVHGIKSLV QHGRESLERQ GQRPCRIPEG CGISDRLGQR SGVSPPSPQR GLPQPPNLLP LLCNGTMTSP ARSSGPRGWK NPLGVLSVLT AISKPFSLCQ PASVTLRLLQ INVFHNASST DMEGMALLGD LETHSLDCSA CQIRFLHTEA VAGPGAADPS LPVQLQPYCE QDSSAAGNGL VSQPDPFVTQ GSLGCELHPN GTSRAFDDTG VNGEDFISFD ADAGKWVARQ GDKLALYARD LLNLDKGTAI TLQFLLRTTC VNQIKSFVQH GNESLERQVP G // ID MICA_HUMAN Reviewed; 383 AA. AC Q29983; A8KQR0; A9LRW5; A9QVE0; B1VJF1; O60917; O60918; O60919; AC O60920; O60933; O77956; O78150; O78151; O78152; O78153; O97987; AC O97988; O97989; O97990; O97991; O97992; O97993; O97994; O97995; AC O98234; O98235; O98236; O98237; O98238; P79506; P79507; P79508; AC P79509; P79510; P79511; P79512; P79513; P79514; P79515; P79516; AC P79517; P79518; P79519; P79520; P79521; Q5C9P8; Q5XM81; Q70I48; AC Q70I49; Q7JFH9; Q7JFI0; Q7JFI1; Q7JFI2; Q7YQ98; Q861I1; Q95464; AC Q95HA2; Q95HD6; Q95HN4; Q95HN5; Q95HN6; Q95IB2; Q95IY7; Q99692; AC Q9BCR3; Q9BCR4; Q9BCR5; Q9BCR6; Q9BCR7; Q9BCR8; Q9BCR9; Q9BCS0; AC Q9BCS1; Q9BCS2; Q9BCS3; Q9BCS4; Q9BD20; Q9GIZ1; Q9GIZ2; Q9GIZ3; AC Q9GIZ4; Q9GIZ5; Q9GIZ6; Q9GJ01; Q9GJ02; Q9GJ03; Q9GJ04; Q9GJ05; AC Q9GJ06; Q9GJ07; Q9GJ08; Q9GJ09; Q9MY21; Q9TQ86; Q9TQ87; Q9TQ88; AC Q9TQ89; Q9TQ92; Q9TQ93; Q9TQ94; Q9TQ95; Q9TQ96; Q9TQ97; Q9TQ98; AC Q9TQ99; Q9TQA0; Q9TQA1; Q9TQA2; Q9TQA3; Q9TQA4; Q9TQI9; Q9TQJ0; AC Q9TQJ1; Q9TQJ9; Q9TQK0; Q9TQK1; Q9TQK2; Q9TQK8; Q9TQK9; Q9TQL0; AC Q9TQL1; Q9TQL2; Q9TQL3; Q9TQL4; Q9UE04; Q9UE05; Q9UE06; Q9UE11; DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 18-JUL-2018, entry version 155. DE RecName: Full=MHC class I polypeptide-related sequence A; DE Short=MIC-A; DE Flags: Precursor; GN Name=MICA {ECO:0000312|EMBL:CAI41907.1}; GN Synonyms=PERB11.1 {ECO:0000303|PubMed:8613147}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] {ECO:0000305, ECO:0000312|EMBL:AAA21718.1} RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE MICA*001). RX PubMed=8022771; DOI=10.1073/pnas.91.14.6259; RA Bahram S., Bresnahan M., Geraghty D.E., Spies T.; RT "A second lineage of mammalian major histocompatibility complex class RT I genes."; RL Proc. Natl. Acad. Sci. U.S.A. 91:6259-6263(1994). RN [2] {ECO:0000305, ECO:0000312|EMBL:CAA63427.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE MICA*004). RX PubMed=8613147; DOI=10.1007/BF02602661; RA Bahram S., Mizuki N., Inoko H., Spies T.; RT "Nucleotide sequence of the human MHC class I MICA gene."; RL Immunogenetics 44:80-81(1996). RN [3] {ECO:0000312|EMBL:CAI41907.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES MICA*001 AND RP MICA*004). RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [4] {ECO:0000305, ECO:0000312|EMBL:AAH16929.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE MICA*018), AND RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-248 (ISOFORM 2). RC TISSUE=Bone, and Kidney {ECO:0000312|EMBL:AAH16929.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] {ECO:0000305} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-150 (ALLELES MICA*001; RP MICA*008 AND MICA*010). RX PubMed=7927538; DOI=10.1007/BF01246675; RA Leelayuwat C., Townend D.C., Degli-Esposti M.A., Abraham L.J., RA Dawkins R.L.; RT "A new polymorphic and multicopy MHC gene family related to RT nonmammalian class I."; RL Immunogenetics 40:339-351(1994). RN [6] {ECO:0000305, ECO:0000312|EMBL:AAB41069.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELES MICA*001; RP MICA*002; MICA*004; MICA*005; MICA*006; MICA*007; MICA*008; MICA*009; RP MICA*010; MICA*011; MICA*012; MICA*013; MICA*014; MICA*015 AND RP MICA*016). RX PubMed=8781120; DOI=10.1007/BF02602779; RA Fodil N., Laloux L., Wanner V., Pellet P., Hauptmann G., Mizuki N., RA Inoko H., Spies T., Theodorou I., Bahram S.; RT "Allelic repertoire of the human MHC class I MICA gene."; RL Immunogenetics 44:351-357(1996). RN [7] {ECO:0000305, ECO:0000312|EMBL:CAA76395.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELES MICA*007; RP MICA*008; MICA*009; MICA*010; MICA*012; MICA*016; MICA*017; MICA*018; RP MICA*022; MICA*024; MICA*025; MICA*028 AND MICA*029). RX PubMed=10331160; DOI=10.1046/j.1365-2370.1999.00094.x; RA Yao Z., Volgger A., Helmberg W., Keller E., Fan L.A., RA Chandanayingyong D., Albert E.D.; RT "Definition of new alleles of MIC-A using sequencing-based typing."; RL Eur. J. Immunogenet. 26:225-232(1999). RN [8] {ECO:0000305, ECO:0000312|EMBL:AAD27009.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELES MICA*009; RP MICA*017; MICA*018 AND MICA*019). RX PubMed=10380703; DOI=10.1007/s002510050536; RA Fodil N., Pellet P., Laloux L., Hauptmann G., Theodorou I., Bahram S.; RT "MICA haplotypic diversity."; RL Immunogenetics 49:557-560(1999). RN [9] {ECO:0000305, ECO:0000312|EMBL:BAA29034.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELE MICA*019). RX PubMed=10369920; DOI=10.1007/s002510050658; RA Komatsu-Wakui M., Tokunaga K., Ishikawa Y., Kashiwase K., Moriyama S., RA Tsuchiya N., Ando H., Shiina T., Geraghty D.E., Inoko H., Juji T.; RT "MIC-A polymorphism in Japanese and a MIC-A-MIC-B null haplotype."; RL Immunogenetics 49:620-628(1999). RN [10] {ECO:0000305, ECO:0000312|EMBL:CAD91415.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELE MICA*051). RC TISSUE=Blood {ECO:0000312|EMBL:CAD91415.1}; RX PubMed=15104678; DOI=10.1111/j.0001-2815.2004.00195.x; RA Quiroga I., Sweeney D., Sutton P.M., Chapple S.D., Souto-Grando J.P., RA Barnardo M.C.N.M., Fuggle S.V.; RT "Identification of a novel MICA allele: MICA*051."; RL Tissue Antigens 63:466-469(2004). RN [11] {ECO:0000305, ECO:0000312|EMBL:AAD01476.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-383 (ALLELES MICA*008; RP MICA*023 AND MICA*028), AND NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF RP 25-341 (ALLELES MICA*001; MICA*002; MICA*004; MICA*006; MICA*007; RP MICA*009; MICA*010; MICA*011; MICA*016; MICA*018; MICA*019; MICA*022; RP MICA*024; MICA*025; MICA*026; MICA*027; MICA*031; MICA*032; MICA*033; RP MICA*034; MICA*035; MICA*036; MICA*037; MICA*038; MICA*039 AND RP MICA*040). RX PubMed=10380704; DOI=10.1007/s002510050537; RA Visser C.J.T., Tilanus M.G.J., Tatari Z., van der Zwan A.-W., RA Bakker R., Rozemuller E.H., Schaeffer V., Tamouza R., Charron D.; RT "Sequencing-based typing of MICA reveals 33 alleles: a study on RT linkage with classical HLA genes."; RL Immunogenetics 49:561-566(1999). RN [12] {ECO:0000305, ECO:0000312|EMBL:AAK19623.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-383 (ALLELES MICA*001; RP MICA*002; MICA*006; MICA*008; MICA*009; MICA*010; MICA*011; MICA*012; RP MICA*015; MICA*016; MICA*017; MICA*018; MICA*019; MICA*048 AND RP MICA*049). RX PubMed=11556982; DOI=10.1034/j.1399-0039.2001.057006520.x; RA Obuchi N., Takahashi M., Nouchi T., Satoh M., Arimura T., Ueda K., RA Akai J., Ota M., Naruse T., Inoko H., Numano F., Kimura A.; RT "Identification of MICA alleles with a long Leu-repeat in the RT transmembrane region and no cytoplasmic tail due to a frameshift- RT deletion in exon 4."; RL Tissue Antigens 57:520-535(2001). RN [13] {ECO:0000305, ECO:0000312|EMBL:CAC27561.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-371 (ALLELES MICA*008; RP MICA*017; MICA*018; MICA*019; MICA*027; MICA*029; MICA*033; MICA*041; RP MICA*043; MICA*045 AND MICA*046). RX PubMed=11841487; DOI=10.1046/j.0960-7420.2001.00275.x; RA Perez-Rodriguez M., Arguello J.R., Fischer G., Corell A., Cox S.T., RA Robinson J., Hossain E., McWhinnie A., Travers P.J., Marsh S.G.E., RA Madrigal J.A.; RT "Further polymorphism of the MICA gene."; RL Eur. J. Immunogenet. 29:35-46(2002). RN [14] {ECO:0000305, ECO:0000312|EMBL:AAV39504.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-371 (ALLELE MICA*008). RA Kaur G., Shiina T., Hashimoto N., Kumar N., Inoko H., Mehra N.K.; RT "MIC-A sequence in AH8.2."; RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000305, ECO:0000312|EMBL:CAB71317.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*020). RX PubMed=10746789; DOI=10.1034/j.1399-0039.2000.550209.x; RA Perez-Rodriguez M., Corell A., Fischer G., Arguello R., Cox S.T., RA McWhinnie A., Marsh S.G.E., Madrigal A.; RT "A new MICA allele with ten alanine residues in the exon 5 RT microsatellite."; RL Tissue Antigens 55:162-165(2000). RN [16] {ECO:0000305, ECO:0000312|EMBL:CAC88121.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*047). RX PubMed=12074712; DOI=10.1034/j.1399-0039.2002.590306.x; RA Perez-Rodriguez M., Raimondi E., Marsh S.G.E., Madrigal J.A.; RT "Identification of a new MICA allele, MICA*047."; RL Tissue Antigens 59:216-218(2002). RN [17] {ECO:0000305, ECO:0000312|EMBL:CAE45582.2} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICA*007; RP MICA*018 AND MICA*053). RX PubMed=16634869; DOI=10.1111/j.1399-0039.2006.00574.x; RA Quiroga I., Sweeney D., Sutton P.M., Ahmad T., Walton R., RA Barnardo M.C.N.M., Fuggle S.V.; RT "The identification of three novel MICA alleles by sequence-based RT typing."; RL Tissue Antigens 67:321-325(2006). RN [18] {ECO:0000305, ECO:0000312|EMBL:AAV39504.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*052). RA Mas V., Amezaga N., Arostegui J.I., Masso M., Plaza S., Rius F., RA Ercilla G., Vives J., Yague J.; RT "Description of a new MICA allele."; RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000305, ECO:0000312|EMBL:AAV39504.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*054). RC TISSUE=Blood {ECO:0000312|EMBL:CAP12057.1}; RA Cox S.T.; RT "Description of a novel MICA allele, MICA*010v, discovered by RT sequencing based typing."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000305, ECO:0000312|EMBL:AAV39504.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*055). RA Glas J., Maier K., Wetzke M., Henninger M., Euba A., Weiss E.H., RA Folwaczny M.; RT "MICA*TM A8: a new allele with eight GCT repeats in the exon 5 RT microsatellite."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0000305, ECO:0000312|EMBL:AAV39504.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*056). RA Cox S.T.; RT "Sequence of new MICA allele, similar to MICA*019."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [22] {ECO:0000305, ECO:0000312|EMBL:AAC28944.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-297 (ALLELES MICA*009; RP MICA*017; MICA*018; MICA*019 AND MICA*030). RX PubMed=10369917; DOI=10.1007/s002510050655; RA Petersdorf E.W., Shuler K.B., Longton G.M., Spies T., Hansen J.A.; RT "Population study of allelic diversity in the human MHC class I- RT related MIC-A gene."; RL Immunogenetics 49:605-612(1999). RN [23] {ECO:0000305, ECO:0000312|EMBL:AAV39504.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-297 (ALLELES MICA*008; RP MICA*012; MICA*041; MICA*042; MICA*043; MICA*044 AND MICA*045). RA Hirose T., Mitsuishi Y., Young C.; RT "New alleles of human non-classical class I MICA gene."; RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases. RN [24] {ECO:0000305, ECO:0000312|EMBL:AAV39504.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-283 (ALLELE MICA*019). RA Yan L., Zhu F.; RT "Identification of a novel MICA allele by SBT."; RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases. RN [25] {ECO:0000305, ECO:0000312|EMBL:AAM34484.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 299-341 (ALLELE MICA*050). RX PubMed=12542746; DOI=10.1034/j.1399-0039.2002.600608.x; RA Rueda B., Pascual M., Lopez-Nevot M.A., Gonzalez E., Martin J.; RT "A new allele within the transmembrane region of the human MICA gene RT with seven GCT repeats."; RL Tissue Antigens 60:526-528(2002). RN [26] {ECO:0000305} RP SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, AND RP GLYCOSYLATION. RX PubMed=8901601; DOI=10.1073/pnas.93.22.12445; RA Groh V., Bahram S., Bauer S., Herman A., Beauchamp M., Spies T.; RT "Cell stress-regulated human major histocompatibility complex class I RT gene expressed in gastrointestinal epithelium."; RL Proc. Natl. Acad. Sci. U.S.A. 93:12445-12450(1996). RN [27] {ECO:0000305} RP SUBUNIT, AND TISSUE SPECIFICITY. RX PubMed=9396860; DOI=10.1007/s002510050339; RA Zwirner N.W., Fernandez-Vina M.A., Stastny P.; RT "MICA, a new polymorphic HLA-related antigen, is expressed mainly by RT keratinocytes, endothelial cells, and monocytes."; RL Immunogenetics 47:139-148(1998). RN [28] {ECO:0000305} RP FUNCTION, AND INDUCTION. RX PubMed=9497295; DOI=10.1126/science.279.5357.1737; RA Groh V., Steinle A., Bauer S., Spies T.; RT "Recognition of stress-induced MHC molecules by intestinal epithelial RT gammadelta T cells."; RL Science 279:1737-1740(1998). RN [29] {ECO:0000305} RP INVOLVEMENT IN PSORIATIC ARTHRITIS SUSCEPTIBILITY. RX PubMed=10323458; RX DOI=10.1002/1529-0131(199905)42:5<1010::AID-ANR21>3.0.CO;2-H; RA Gonzalez S., Martinez-Borra J., Torre-Alonso J.C., Gonzalez-Roces S., RA Sanchez del Rio J., Rodriguez Perez A., Brautbar C., Lopez-Larrea C.; RT "The MICA-A9 triplet repeat polymorphism in the transmembrane region RT confers additional susceptibility to the development of psoriatic RT arthritis and is independent of the association of Cw*0602 in RT psoriasis."; RL Arthritis Rheum. 42:1010-1016(1999). RN [30] {ECO:0000305} RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY. RX PubMed=10363723; DOI=10.1016/S0198-8859(98)00128-1; RA Zwirner N.W., Dole K., Stastny P.; RT "Differential surface expression of MICA by endothelial cells, RT fibroblasts, keratinocytes, and monocytes."; RL Hum. Immunol. 60:323-330(1999). RN [31] {ECO:0000305} RP TISSUE SPECIFICITY. RX PubMed=10359807; DOI=10.1073/pnas.96.12.6879; RA Groh V., Rhinehart R., Secrist H., Bauer S., Grabstein K.H., Spies T.; RT "Broad tumor-associated expression and recognition by tumor-derived RT gamma delta T cells of MICA and MICB."; RL Proc. Natl. Acad. Sci. U.S.A. 96:6879-6884(1999). RN [32] {ECO:0000305} RP FUNCTION, AND INTERACTION WITH KLRK1. RX PubMed=10426993; DOI=10.1126/science.285.5428.727; RA Bauer S., Groh V., Wu J., Steinle A., Phillips J.H., Lanier L.L., RA Spies T.; RT "Activation of NK cells and T cells by NKG2D, a receptor for stress- RT inducible MICA."; RL Science 285:727-729(1999). RN [33] {ECO:0000305} RP SUBUNIT. RX PubMed=10426994; DOI=10.1126/science.285.5428.730; RA Wu J., Song Y., Bakker A.B.H., Bauer S., Spies T., Lanier L.L., RA Phillips J.H.; RT "An activating immunoreceptor complex formed by NKG2D and DAP10."; RL Science 285:730-732(1999). RN [34] {ECO:0000305} RP TISSUE SPECIFICITY, AND ASSOCIATION WITH PSORIASIS. RX PubMed=10691930; DOI=10.1046/j.1365-2249.2000.01140.x; RA Tay G.K., Hui J., Gaudieri S., Schmitt-Egenolf M., Martinez O.P., RA Leelayuwat C., Williamson J.F., Eiermann T.H., Dawkins R.L.; RT "PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single RT nucleotide polymorphisms are associated with psoriasis."; RL Clin. Exp. Immunol. 119:553-558(2000). RN [35] {ECO:0000305} RP IDENTIFICATION AS AN ALLOANTIGEN. RX PubMed=11053635; DOI=10.1016/S0198-8859(00)00162-2; RA Zwirner N.W., Marcos C.Y., Mirbaha F., Zou Y., Stastny P.; RT "Identification of MICA as a new polymorphic alloantigen recognized by RT antibodies in sera of organ transplant recipients."; RL Hum. Immunol. 61:917-924(2000). RN [36] RP FUNCTION AS A LIGAND FOR KLRK1. RX PubMed=11777960; DOI=10.4049/jimmunol.168.2.671; RA Sutherland C.L., Chalupny N.J., Schooley K., VandenBos T., Kubin M., RA Cosman D.; RT "UL16-binding proteins, novel MHC class I-related proteins, bind to RT NKG2D and activate multiple signaling pathways in primary NK cells."; RL J. Immunol. 168:671-679(2002). RN [37] RP INTERACTION WITH HHV-5 PROTEIN UL142 (MICROBIAL INFECTION). RX PubMed=19793804; DOI=10.1128/JVI.01175-09; RA Ashiru O., Bennett N.J., Boyle L.H., Thomas M., Trowsdale J., RA Wills M.R.; RT "NKG2D ligand MICA is retained in the cis-Golgi apparatus by human RT cytomegalovirus protein UL142."; RL J. Virol. 83:12345-12354(2009). RN [38] {ECO:0000305} RP VARIANT PRO-29. RX PubMed=10752636; DOI=10.1007/s002510050039; RA Li Z., Groh V., Strong R.K., Spies T.; RT "A single amino acid substitution causes loss of expression of a MICA RT allele."; RL Immunogenetics 51:246-248(2000). RN [39] {ECO:0000305} RP INDUCTION. RX PubMed=11485740; DOI=10.1016/S1074-7613(01)00168-6; RA Das H., Groh V., Kuijl C., Sugita M., Morita C.T., Spies T., RA Bukowski J.F.; RT "MICA engagement by human Vgamma2Vdelta2 T cells enhances their RT antigen-dependent effector function."; RL Immunity 15:83-93(2001). RN [40] {ECO:0000305} RP FUNCTION, INTERACTION WITH KLRK1, AND EFFECT OF VARIANT VAL-152 ON RP BINDING TO KLRK1. RX PubMed=11491531; DOI=10.1007/s002510100325; RA Steinle A., Li P., Morris D.L., Groh V., Lanier L.L., Strong R.K., RA Spies T.; RT "Interactions of human NKG2D with its ligands MICA, MICB, and homologs RT of the mouse RAE-1 protein family."; RL Immunogenetics 53:279-287(2001). RN [41] {ECO:0000305} RP FUNCTION AS A LIGAND FOR KLRK1, AND INDUCTION. RX PubMed=11224526; DOI=10.1038/85321; RA Groh V., Rhinehart R., Randolph-Habecker J., Topp M.S., Riddell S.R., RA Spies T.; RT "Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC RT induced on virus-infected cells."; RL Nat. Immunol. 2:255-260(2001). RN [42] {ECO:0000305} RP ALTERNATIVE SPLICING (ISOFORMS 1 AND 2). RX PubMed=12466900; DOI=10.1007/s00251-002-0496-y; RA Zou Y., Stastny P.; RT "Alternatively spliced forms of MICA and MICB lacking exon 3 in a RT human cell line and evidence of presence of similar RNA in human RT peripheral blood mononuclear cells."; RL Immunogenetics 54:671-674(2002). RN [43] {ECO:0000305} RP PROTEOLYTIC CLEAVAGE ON TUMOR CELLS. RX PubMed=12370336; DOI=10.4049/jimmunol.169.8.4098; RA Salih H.R., Rammensee H.-G., Steinle A.; RT "Down-regulation of MICA on human tumors by proteolytic shedding."; RL J. Immunol. 169:4098-4102(2002). RN [44] {ECO:0000305} RP PROTEOLYTIC CLEAVAGE ON TUMOR CELLS. RX PubMed=12384702; DOI=10.1038/nature01112; RA Groh V., Wu J., Yee C., Spies T.; RT "Tumour-derived soluble MIC ligands impair expression of NKG2D and T- RT cell activation."; RL Nature 419:734-738(2002). RN [45] {ECO:0000305} RP INDUCTION. RX PubMed=11830641; DOI=10.1073/pnas.032668099; RA Tieng V., Le Bouguenec C., du Merle L., Bertheau P., Desreumaux P., RA Janin A., Charron D., Toubert A.; RT "Binding of Escherichia coli adhesin AfaE to CD55 triggers cell- RT surface expression of the MHC class I-related molecule MICA."; RL Proc. Natl. Acad. Sci. U.S.A. 99:2977-2982(2002). RN [46] {ECO:0000305} RP TISSUE SPECIFICITY. RX PubMed=12902493; DOI=10.4049/jimmunol.171.4.1909; RA Hue S., Monteiro R.C., Berrih-Aknin S., Caillat-Zucman S.; RT "Potential role of NKG2D/MHC class I-related chain A interaction in RT intrathymic maturation of single-positive CD8 T cells."; RL J. Immunol. 171:1909-1917(2003). RN [47] {ECO:0000305} RP INDUCTION. RX PubMed=15995699; DOI=10.1038/nature03884; RA Gasser S., Orsulic S., Brown E.J., Raulet D.H.; RT "The DNA damage pathway regulates innate immune system ligands of the RT NKG2D receptor."; RL Nature 436:1186-1190(2005). RN [48] {ECO:0000305} RP INDUCTION. RX PubMed=16750166; DOI=10.1016/j.bbrc.2006.05.092; RA Chalupny N.J., Rein-Weston A., Dosch S., Cosman D.; RT "Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus RT glycoprotein UL142."; RL Biochem. Biophys. Res. Commun. 346:175-181(2006). RN [49] {ECO:0000305} RP INTERACTION WITH PDIA6. RX PubMed=17495932; DOI=10.1038/nature05768; RA Kaiser B.K., Yim D., Chow I.-T., Gonzalez S., Dai Z., Mann H.H., RA Strong R.K., Groh V., Spies T.; RT "Disulphide-isomerase-enabled shedding of tumour-associated NKG2D RT ligands."; RL Nature 447:482-486(2007). RN [50] {ECO:0000305} RP TISSUE SPECIFICITY. RX PubMed=17565371; DOI=10.1371/journal.pone.0000518; RA Schrambach S., Ardizzone M., Leymarie V., Sibilia J., Bahram S.; RT "In vivo expression pattern of MICA and MICB and its relevance to RT auto-immunity and cancer."; RL PLoS ONE 2:E518-E518(2007). RN [51] {ECO:0000305} RP SUBCELLULAR LOCATION, AND INDUCTION. RX PubMed=18287244; DOI=10.1128/JVI.02251-07; RA McSharry B.P., Burgert H.-G., Owen D.P., Stanton R.J., Prod'homme V., RA Sester M., Koebernick K., Groh V., Spies T., Cox S.T., Little A.-M., RA Wang E.C.Y., Tomasec P., Wilkinson G.W.; RT "Adenovirus E3/19K promotes evasion of NK cell recognition by RT intracellular sequestration of the NKG2D ligands MICA and MICB."; RL J. Virol. 82:4585-4594(2008). RN [52] {ECO:0000305} RP INVOLVEMENT IN MULTIPLE MYELOMA. RX PubMed=18202175; DOI=10.1073/pnas.0711293105; RA Jinushi M., Vanneman M., Munshi N.C., Tai Y.-T., Prabhala R.H., RA Ritz J., Neuberg D., Anderson K.C., Carrasco D.R., Dranoff G.; RT "MHC class I chain-related protein A antibodies and shedding are RT associated with the progression of multiple myeloma."; RL Proc. Natl. Acad. Sci. U.S.A. 105:1285-1290(2008). RN [53] {ECO:0000305} RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 24-297, AND DISULFIDE BONDS. RX PubMed=10367903; DOI=10.1016/S1074-7613(00)80057-6; RA Li P., Willie S.T., Bauer S., Morris D.L., Spies T., Strong R.K.; RT "Crystal structure of the MHC class I homolog MIC-A, a gammadelta T RT cell ligand."; RL Immunity 10:577-584(1999). RN [54] {ECO:0000305, ECO:0000312|PDB:1HYR} RP X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 24-297 IN COMPLEX WITH KLRK1. RX PubMed=11323699; DOI=10.1038/87757; RA Li P., Morris D.L., Willcox B.E., Steinle A., Spies T., Strong R.K.; RT "Complex structure of the activating immunoreceptor NKG2D and its MHC RT class I-like ligand MICA."; RL Nat. Immunol. 2:443-451(2001). CC -!- FUNCTION: Seems to have no role in antigen presentation. Acts as a CC stress-induced self-antigen that is recognized by gamma delta T- CC cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads CC to cell lysis. {ECO:0000269|PubMed:10426993, CC ECO:0000269|PubMed:11224526, ECO:0000269|PubMed:11491531, CC ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:9497295}. CC -!- SUBUNIT: Unlike classical MHC class I molecules, does not form a CC heterodimer with beta-2-microglobulin. Binds as a monomer to a CC KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in CC which KLRK1 binds MICA while HCST acts as an adapter molecule CC which enables signal transduction. Interacts with PDIA6 on the CC surface of tumor cells, leading to disulfide bond reduction which CC is required for release of MICA from tumor cells. Interacts with CC human cytomegalovirus/HHV-5 protein UL142. CC {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:10426994, CC ECO:0000269|PubMed:11323699, ECO:0000269|PubMed:11491531, CC ECO:0000269|PubMed:17495932, ECO:0000269|PubMed:8901601, CC ECO:0000269|PubMed:9396860}. CC -!- SUBUNIT: (Microbial infection) Interacts with human CC cytomegalovirus/HHV-5 protein UL142. CC {ECO:0000269|PubMed:19793804}. CC -!- INTERACTION: CC P26718:KLRK1; NbExp=2; IntAct=EBI-1031130, EBI-458344; CC P17931:LGALS3; NbExp=2; IntAct=EBI-1031130, EBI-1170392; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10363723, CC ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}; Single- CC pass type I membrane protein {ECO:0000269|PubMed:10363723, CC ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}. CC Cytoplasm {ECO:0000269|PubMed:10363723, CC ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}. CC Note=Expressed on the cell surface in gastric epithelium, CC endothelial cells and fibroblasts and in the cytoplasm in CC keratinocytes and monocytes. Infection with human adenovirus 5 CC suppresses cell surface expression due to the adenoviral E3-19K CC protein which causes retention in the endoplasmic reticulum. CC {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244, CC ECO:0000269|PubMed:8901601}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1 {ECO:0000269|PubMed:12466900}; Synonyms=MICA1 CC {ECO:0000269|PubMed:12466900}; CC IsoId=Q29983-1; Sequence=Displayed; CC Name=2 {ECO:0000269|PubMed:12466900}; Synonyms=MICA2 CC {ECO:0000269|PubMed:12466900}; CC IsoId=Q29983-2; Sequence=VSP_055366; CC Note=Found in about 10% of examined clones.; CC -!- TISSUE SPECIFICITY: Widely expressed with the exception of the CC central nervous system where it is absent. Expressed predominantly CC in gastric epithelium and also in monocytes, keratinocytes, CC endothelial cells, fibroblasts and in the outer layer of Hassal's CC corpuscles within the medulla of normal thymus. In skin, expressed CC mainly in the keratin layers, basal cells, ducts and follicles. CC Also expressed in many, but not all, epithelial tumors of lung, CC breast, kidney, ovary, prostate and colon. In thyomas, CC overexpressed in cortical and medullar epithelial cells. Tumors CC expressing MICA display increased levels of gamma delta T-cells. CC {ECO:0000269|PubMed:10359807, ECO:0000269|PubMed:10363723, CC ECO:0000269|PubMed:10691930, ECO:0000269|PubMed:12902493, CC ECO:0000269|PubMed:17565371, ECO:0000269|PubMed:8901601, CC ECO:0000269|PubMed:9396860}. CC -!- INDUCTION: By heat shock, by infection with human cytomegalovirus CC (HCMV), human adenovirus 5, M.tuberculosis and diarrheagenic CC E.coli, and by exposure to DNA damaging conditions such as high CC doses of ionizing radiation, chromatin-modifying treatments and CC inhibitors of DNA replication. The HCMV UL142 protein causes down- CC regulation of the full-length protein but not of the truncated CC MICA*008 allele. {ECO:0000269|PubMed:11224526, CC ECO:0000269|PubMed:11485740, ECO:0000269|PubMed:11830641, CC ECO:0000269|PubMed:15995699, ECO:0000269|PubMed:16750166, CC ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601, CC ECO:0000269|PubMed:9497295}. CC -!- PTM: N-glycosylated. Glycosylation is not essential for CC interaction with KLRK1/NKG2D but enhances complex formation. CC {ECO:0000269|PubMed:8901601}. CC -!- PTM: Proteolytically cleaved and released from the cell surface of CC tumor cells which impairs KLRK1/NKG2D expression and T-cell CC activation. {ECO:0000269|PubMed:12370336, CC ECO:0000269|PubMed:12384702}. CC -!- POLYMORPHISM: The following alleles of MICA are known: MICA*001, CC MICA*002, MICA*004, MICA*005, MICA*006, MICA*007, MICA*008, CC MICA*009, MICA*010, MICA*011, MICA*012, MICA*013, MICA*014, CC MICA*015, MICA*016, MICA*017, MICA*018, MICA*019, MICA*020, CC MICA*022, MICA*023, MICA*024, MICA*025, MICA*026, MICA*027, CC MICA*028, MICA*029, MICA*030, MICA*031, MICA*032, MICA*033, CC MICA*034, MICA*035, MICA*036, MICA*037, MICA*038, MICA*039, CC MICA*040, MICA*041, MICA*042, MICA*043, MICA*044, MICA*045, CC MICA*046, MICA*047, MICA*048, MICA*049, MICA*050, MICA*051, CC MICA*052, MICA*053, MICA*054, MICA*055 and MICA*056. The sequence CC shown is that of MICA*001. {ECO:0000305}. CC -!- DISEASE: Note=Anti-MICA antibodies and ligand shedding are CC involved in the progression of monoclonal gammopathy of CC undetermined significance (MGUS)to multiple myeloma. CC -!- DISEASE: Psoriasis 1 (PSORS1) [MIM:177900]: A common, chronic CC inflammatory disease of the skin with multifactorial etiology. It CC is characterized by red, scaly plaques usually found on the scalp, CC elbows and knees. These lesions are caused by abnormal CC keratinocyte proliferation and infiltration of inflammatory cells CC into the dermis and epidermis. Note=Disease susceptibility is CC associated with variations affecting the gene represented in this CC entry. CC -!- DISEASE: Psoriatic arthritis (PSORAS) [MIM:607507]: An CC inflammatory, seronegative arthritis associated with psoriasis. It CC is a heterogeneous disorder ranging from a mild, non-destructive CC disease to a severe, progressive, erosive arthropathy. Five types CC of psoriatic arthritis have been defined: asymmetrical CC oligoarthritis characterized by primary involvement of the small CC joints of the fingers or toes; asymmetrical arthritis which CC involves the joints of the extremities; symmetrical polyarthritis CC characterized by a rheumatoid like pattern that can involve hands, CC wrists, ankles, and feet; arthritis mutilans, which is a rare but CC deforming and destructive condition; arthritis of the sacroiliac CC joints and spine (psoriatic spondylitis). CC {ECO:0000269|PubMed:10323458}. Note=Disease susceptibility is CC associated with variations affecting the gene represented in this CC entry. CC -!- MISCELLANEOUS: Recognized by antibodies in the sera of some organ CC transplant recipients and may be a target molecule in allograft CC rejection. {ECO:0000269|PubMed:11053635}. CC -!- SIMILARITY: Belongs to the MHC class I family. MIC subfamily. CC {ECO:0000255}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; L14848; AAA21718.1; -; mRNA. DR EMBL; X92841; CAA63427.1; -; Genomic_DNA. DR EMBL; AL845443; CAI41907.1; -; Genomic_DNA. DR EMBL; CR847852; CAQ11015.1; -; Genomic_DNA. DR EMBL; BC016929; AAH16929.1; -; mRNA. DR EMBL; BG114064; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; L29406; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; L29408; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; L29409; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; L29411; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; U56940; AAB41060.1; -; Genomic_DNA. DR EMBL; U56941; AAB41061.1; -; Genomic_DNA. DR EMBL; U56942; AAB41062.1; -; Genomic_DNA. DR EMBL; U56943; AAB41063.1; -; Genomic_DNA. DR EMBL; U56944; AAB41064.1; -; Genomic_DNA. DR EMBL; U56945; AAB41065.1; -; Genomic_DNA. DR EMBL; U56946; AAB41066.1; -; Genomic_DNA. DR EMBL; U56947; AAB41067.1; -; Genomic_DNA. DR EMBL; U56948; AAB41068.1; -; Genomic_DNA. DR EMBL; U56949; AAB41069.1; -; Genomic_DNA. DR EMBL; U56950; AAB41070.1; -; Genomic_DNA. DR EMBL; U56951; AAB41071.1; -; Genomic_DNA. DR EMBL; U56952; AAB41072.1; -; Genomic_DNA. DR EMBL; U56953; AAB41073.1; -; Genomic_DNA. DR EMBL; U56954; AAB41074.1; -; Genomic_DNA. DR EMBL; U56955; AAB41075.1; -; Genomic_DNA. DR EMBL; Y16801; CAA76393.1; -; Genomic_DNA. DR EMBL; Y16802; CAA76394.1; -; Genomic_DNA. DR EMBL; Y16803; CAA76395.1; -; Genomic_DNA. DR EMBL; Y16804; CAA76396.1; -; Genomic_DNA. DR EMBL; Y16805; CAA76397.1; -; Genomic_DNA. DR EMBL; Y16806; CAA76398.1; -; Genomic_DNA. DR EMBL; Y16807; CAA76399.1; -; Genomic_DNA. DR EMBL; Y16808; CAA76400.1; -; Genomic_DNA. DR EMBL; Y16809; CAA76401.1; -; Genomic_DNA. DR EMBL; Y16810; CAA76402.1; -; Genomic_DNA. DR EMBL; Y16811; CAA76403.1; -; Genomic_DNA. DR EMBL; Y18110; CAA77029.1; -; Genomic_DNA. DR EMBL; Y18111; CAA77030.1; -; Genomic_DNA. DR EMBL; Y18112; CAA77031.1; -; Genomic_DNA. DR EMBL; AF097403; AAD27006.1; -; Genomic_DNA. DR EMBL; AF097404; AAD27007.1; -; Genomic_DNA. DR EMBL; AF097405; AAD27008.1; -; Genomic_DNA. DR EMBL; AF097406; AAD27009.1; -; Genomic_DNA. DR EMBL; AB015600; BAA29034.1; -; Genomic_DNA. DR EMBL; AJ563426; CAD91415.1; -; Genomic_DNA. DR EMBL; AH007168; AAD01474.1; -; Genomic_DNA. DR EMBL; AH007170; AAD01476.1; -; Genomic_DNA. DR EMBL; AH007171; AAD01477.1; -; Genomic_DNA. DR EMBL; AH007173; AAD01479.1; -; Genomic_DNA. DR EMBL; AH007174; AAD01480.1; -; Genomic_DNA. DR EMBL; AH007186; AAD01492.1; -; Genomic_DNA. DR EMBL; AH007175; AAD01481.1; -; Genomic_DNA. DR EMBL; AH007176; AAD01482.1; -; Genomic_DNA. DR EMBL; AH007177; AAD01483.1; -; Genomic_DNA. DR EMBL; AH007178; AAD01484.1; -; Genomic_DNA. DR EMBL; AH007179; AAD01485.1; -; Genomic_DNA. DR EMBL; AH007180; AAD01486.1; -; Genomic_DNA. DR EMBL; AH007182; AAD01488.1; -; Genomic_DNA. DR EMBL; AH007183; AAD01489.1; -; Genomic_DNA. DR EMBL; AH007184; AAD01490.1; -; Genomic_DNA. DR EMBL; AH007185; AAD01491.1; -; Genomic_DNA. DR EMBL; AH008136; AAD52060.1; -; Genomic_DNA. DR EMBL; AH008137; AAD52061.1; -; Genomic_DNA. DR EMBL; AH008138; AAD52062.1; -; Genomic_DNA. DR EMBL; AH008139; AAD52063.1; -; Genomic_DNA. DR EMBL; AH008140; AAD52064.1; -; Genomic_DNA. DR EMBL; AH008141; AAD52065.1; -; Genomic_DNA. DR EMBL; AH008142; AAD52066.1; -; Genomic_DNA. DR EMBL; AH008143; AAD52067.1; -; Genomic_DNA. DR EMBL; AH008144; AAD52068.1; -; Genomic_DNA. DR EMBL; AH008145; AAD52069.1; -; Genomic_DNA. DR EMBL; AH008146; AAD52070.1; -; Genomic_DNA. DR EMBL; AH008147; AAD52071.1; -; Genomic_DNA. DR EMBL; AH008148; AAD52072.1; -; Genomic_DNA. DR EMBL; AH007169; AAD01475.1; -; Genomic_DNA. DR EMBL; AH007172; AAD01478.1; -; Genomic_DNA. DR EMBL; AH007167; AAD01473.1; -; Genomic_DNA. DR EMBL; AH007181; AAD01487.1; -; Genomic_DNA. DR EMBL; AH010819; AAK58536.1; -; Genomic_DNA. DR EMBL; AH011143; AAL13171.1; -; Genomic_DNA. DR EMBL; AH010820; AAK58537.1; -; Genomic_DNA. DR EMBL; AH010821; AAK58538.1; -; Genomic_DNA. DR EMBL; AH010545; AAK19622.1; -; Genomic_DNA. DR EMBL; AH010526; AAK17997.1; -; Genomic_DNA. DR EMBL; AH010568; AAK25770.1; -; Genomic_DNA. DR EMBL; AH010569; AAK25771.1; -; Genomic_DNA. DR EMBL; AH010532; AAK18281.1; -; Genomic_DNA. DR EMBL; AH010546; AAK19623.1; -; Genomic_DNA. DR EMBL; AH010560; AAK20897.1; -; Genomic_DNA. DR EMBL; AH010561; AAK20898.1; -; Genomic_DNA. DR EMBL; AH010587; AAK27364.1; -; Genomic_DNA. DR EMBL; AH010562; AAK20899.1; -; Genomic_DNA. DR EMBL; AH010571; AAK26323.1; -; Genomic_DNA. DR EMBL; AH010572; AAK26324.1; -; Genomic_DNA. DR EMBL; AH010740; AAK51140.1; -; Genomic_DNA. DR EMBL; AJ250499; CAC14280.1; -; Genomic_DNA. DR EMBL; AJ250500; CAC14281.1; -; Genomic_DNA. DR EMBL; AJ250501; CAC14282.1; -; Genomic_DNA. DR EMBL; AJ250502; CAC14283.1; -; Genomic_DNA. DR EMBL; AJ250503; CAC14284.1; -; Genomic_DNA. DR EMBL; AJ250504; CAC14285.1; -; Genomic_DNA. DR EMBL; AJ250505; CAC14286.1; -; Genomic_DNA. DR EMBL; AJ250506; CAC14287.1; -; Genomic_DNA. DR EMBL; AJ250507; CAC14288.1; -; Genomic_DNA. DR EMBL; AJ250802; CAC15380.1; -; Genomic_DNA. DR EMBL; AJ250803; CAC15381.1; -; Genomic_DNA. DR EMBL; AJ250804; CAC15382.1; -; Genomic_DNA. DR EMBL; AJ250805; CAC15383.1; -; Genomic_DNA. DR EMBL; AJ250990; CAC16142.1; -; Genomic_DNA. DR EMBL; AJ250991; CAC16143.1; -; Genomic_DNA. DR EMBL; AJ271789; CAC27561.1; -; Genomic_DNA. DR EMBL; AY603357; AAV39504.1; -; Genomic_DNA. DR EMBL; AJ249394; CAB71317.1; -; Genomic_DNA. DR EMBL; AJ295250; CAC88121.1; -; Genomic_DNA. DR EMBL; AJ295251; CAC88121.1; JOINED; Genomic_DNA. DR EMBL; AJ580805; CAE45581.1; -; Genomic_DNA. DR EMBL; AJ580806; CAE45582.2; -; Genomic_DNA. DR EMBL; AH014149; AAU95382.1; -; Genomic_DNA. DR EMBL; AM899996; CAP12057.1; -; Genomic_DNA. DR EMBL; EU254723; ABX54884.1; -; Genomic_DNA. DR EMBL; AM944063; CAQ16171.1; -; Genomic_DNA. DR EMBL; AH006330; AAC28941.1; -; Genomic_DNA. DR EMBL; AH006331; AAC28942.1; -; Genomic_DNA. DR EMBL; AH006332; AAC28943.1; -; Genomic_DNA. DR EMBL; AH006333; AAC28944.1; -; Genomic_DNA. DR EMBL; AH006334; AAC28945.1; -; Genomic_DNA. DR EMBL; AH007472; AAD19598.1; -; Genomic_DNA. DR EMBL; AH007473; AAD19599.1; -; Genomic_DNA. DR EMBL; AH007474; AAD19600.1; -; Genomic_DNA. DR EMBL; AH007475; AAD19601.1; -; Genomic_DNA. DR EMBL; AH007476; AAD19602.1; -; Genomic_DNA. DR EMBL; AH007477; AAD19603.1; -; Genomic_DNA. DR EMBL; AF106652; AAD19604.1; -; Genomic_DNA. DR EMBL; AF106650; AAD19604.1; JOINED; Genomic_DNA. DR EMBL; AF106651; AAD19604.1; JOINED; Genomic_DNA. DR EMBL; AH007479; AAD19605.1; -; Genomic_DNA. DR EMBL; EU267602; ABX60404.1; -; Genomic_DNA. DR EMBL; AY095537; AAM34484.1; -; Genomic_DNA. DR PIR; A55739; A55739. DR RefSeq; NP_000238.1; NM_000247.2. [Q29983-1] DR UniGene; Hs.130838; -. DR PDB; 1B3J; X-ray; 3.00 A; A=24-297. DR PDB; 1HYR; X-ray; 2.70 A; C=24-297. DR PDBsum; 1B3J; -. DR PDBsum; 1HYR; -. DR DisProt; DP00670; -. DR ProteinModelPortal; Q29983; -. DR SMR; Q29983; -. DR BioGrid; 319735; 42. DR CORUM; Q29983; -. DR DIP; DIP-29681N; -. DR IntAct; Q29983; 3. DR MINT; Q29983; -. DR iPTMnet; Q29983; -. DR PhosphoSitePlus; Q29983; -. DR SwissPalm; Q29983; -. DR DMDM; 74740024; -. DR EPD; Q29983; -. DR MaxQB; Q29983; -. DR PeptideAtlas; Q29983; -. DR PRIDE; Q29983; -. DR ProteomicsDB; 61284; -. DR Ensembl; ENST00000400325; ENSP00000383179; ENSG00000183214. [Q29983-1] DR Ensembl; ENST00000418465; ENSP00000402134; ENSG00000235233. DR Ensembl; ENST00000547609; ENSP00000446963; ENSG00000183214. [Q29983-1] DR GeneID; 100507436; -. DR KEGG; hsa:100507436; -. DR UCSC; uc011ind.3; human. [Q29983-1] DR CTD; 100507436; -. DR DisGeNET; 100507436; -. DR GeneCards; MICA; -. DR HGNC; HGNC:7090; MICA. DR HPA; HPA064618; -. DR MIM; 177900; phenotype. DR MIM; 600169; gene. DR MIM; 607507; phenotype. DR neXtProt; NX_Q29983; -. DR PharmGKB; PA30811; -. DR HOVERGEN; HBG106364; -. DR InParanoid; Q29983; -. DR KO; K07985; -. DR OrthoDB; EOG091G0ANY; -. DR PhylomeDB; Q29983; -. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR ChiTaRS; MICA; human. DR EvolutionaryTrace; Q29983; -. DR GeneWiki; MHC_class_I_polypeptide-related_sequence_A; -. DR GenomeRNAi; 100507436; -. DR PMAP-CutDB; Q29983; -. DR PRO; PR:Q29983; -. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0009986; C:cell surface; IDA:UniProtKB. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005615; C:extracellular space; IDA:BHF-UCL. DR GO; GO:0005887; C:integral component of plasma membrane; IDA:BHF-UCL. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IDA:UniProtKB. DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IDA:UniProtKB. DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW. DR GO; GO:0042742; P:defense response to bacterium; IDA:UniProtKB. DR GO; GO:0051607; P:defense response to virus; IDA:UniProtKB. DR GO; GO:0046629; P:gamma-delta T cell activation; IDA:UniProtKB. DR GO; GO:0002418; P:immune response to tumor cell; IDA:UniProtKB. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0032815; P:negative regulation of natural killer cell activation; IDA:CACAO. DR GO; GO:0045953; P:negative regulation of natural killer cell mediated cytotoxicity; IMP:CACAO. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0009408; P:response to heat; IDA:UniProtKB. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0016032; P:viral process; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW 3D-structure; Adaptive immunity; Alternative splicing; Cell membrane; KW Complete proteome; Cytolysis; Cytoplasm; Disulfide bond; Glycoprotein; KW Host-virus interaction; Immunity; Immunoglobulin domain; Membrane; KW Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 23 FT CHAIN 24 383 MHC class I polypeptide-related sequence FT A. {ECO:0000255}. FT /FTId=PRO_0000337146. FT TOPO_DOM 24 307 Extracellular. {ECO:0000255}. FT TRANSMEM 308 328 Helical. {ECO:0000255}. FT TOPO_DOM 329 383 Cytoplasmic. {ECO:0000255}. FT DOMAIN 207 296 Ig-like C1-type. {ECO:0000255}. FT CARBOHYD 31 31 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 79 79 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 210 210 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 220 220 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 261 261 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 59 64 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:10367903}. FT DISULFID 119 187 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:10367903}. FT DISULFID 225 282 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:10367903}. FT VAR_SEQ 109 204 Missing (in isoform 2). FT {ECO:0000303|PubMed:15489334}. FT /FTId=VSP_055366. FT VARIANT 29 29 R -> P (in allele MICA*010, allele FT MICA*025 and allele MICA*054; abolishes FT cell surface expression, probably by FT interfering with protein folding; FT dbSNP:rs9380254). FT {ECO:0000269|PubMed:10752636}. FT /FTId=VAR_043625. FT VARIANT 37 37 W -> G (in allele MICA*002, allele FT MICA*011, allele MICA*013, allele FT MICA*014, allele MICA*015, allele FT MICA*017, allele MICA*020, allele FT MICA*022, allele MICA*023, allele FT MICA*030, allele MICA*034, allele FT MICA*035, allele MICA*036, allele FT MICA*041, allele MICA*044, allele FT MICA*046, allele MICA*047, allele FT MICA*052, allele MICA*053 and allele FT MICA*055; dbSNP:rs1063630). FT /FTId=VAR_043626. FT VARIANT 47 47 T -> A (in allele MICA*002, allele FT MICA*004, allele MICA*005, allele FT MICA*006, allele MICA*007, allele FT MICA*008, allele MICA*009, allele FT MICA*010, allele MICA*011, allele FT MICA*013, allele MICA*014, allele FT MICA*015, allele MICA*016, allele FT MICA*017, allele MICA*019, allele FT MICA*020, allele MICA*022, allele FT MICA*023, allele MICA*024, allele FT MICA*025, allele MICA*026, allele FT MICA*027, allele MICA*028, allele FT MICA*029, allele MICA*030, allele FT MICA*031, allele MICA*032, allele FT MICA*033, allele MICA*034, allele FT MICA*035, allele MICA*036, allele FT MICA*037, allele MICA*038, allele FT MICA*039, allele MICA*040, allele FT MICA*041, allele MICA*042, allele FT MICA*043, allele MICA*044, allele FT MICA*045, allele MICA*046, allele FT MICA*047, allele MICA*048, allele FT MICA*049, allele MICA*051, allele FT MICA*052, allele MICA*053, allele FT MICA*054, allele MICA*055 and allele FT MICA*056; dbSNP:rs1051785). FT /FTId=VAR_043627. FT VARIANT 49 49 V -> G (in allele MICA*041; FT dbSNP:rs17200158). FT /FTId=VAR_043628. FT VARIANT 59 59 C -> Y (in allele MICA*004, allele FT MICA*005, allele MICA*006, allele FT MICA*008, allele MICA*009, allele FT MICA*010, allele MICA*016, allele FT MICA*019, allele MICA*024, allele FT MICA*025, allele MICA*027, allele FT MICA*028, allele MICA*031, allele FT MICA*032, allele MICA*033, allele FT MICA*042, allele MICA*044, allele FT MICA*048, allele MICA*049, allele FT MICA*051, allele MICA*054 and allele FT MICA*056; dbSNP:rs1051786). FT /FTId=VAR_043629. FT VARIANT 114 114 Q -> R (in allele MICA*017; FT dbSNP:rs41558312). FT /FTId=VAR_043630. FT VARIANT 128 128 R -> K (in allele MICA*036; FT dbSNP:rs41557113). FT /FTId=VAR_043631. FT VARIANT 137 137 G -> R (in allele MICA*014 and allele FT MICA*015; dbSNP:rs41556715). FT /FTId=VAR_043632. FT VARIANT 145 145 L -> V (in allele MICA*004, allele FT MICA*006, allele MICA*009, allele FT MICA*044 and allele MICA*049; FT dbSNP:rs1051790). FT /FTId=VAR_043633. FT VARIANT 147 147 T -> S (in allele MICA*033; FT dbSNP:rs41539919). FT /FTId=VAR_043634. FT VARIANT 148 148 K -> E (in allele MICA*002, allele FT MICA*004, allele MICA*005, allele FT MICA*006, allele MICA*007, allele FT MICA*008, allele MICA*009, allele FT MICA*010, allele MICA*011, allele FT MICA*012, allele MICA*013, allele FT MICA*014, allele MICA*015, allele FT MICA*016, allele MICA*017, allele FT MICA*018, allele MICA*019, allele FT MICA*020, allele MICA*022, allele FT MICA*023, allele MICA*024, allele FT MICA*025, allele MICA*026, allele FT MICA*027, allele MICA*028, allele FT MICA*029, allele MICA*030, allele FT MICA*032, allele MICA*033, allele FT MICA*034, allele MICA*035, allele FT MICA*036, allele MICA*037, allele FT MICA*038, allele MICA*039, allele FT MICA*041, allele MICA*042, allele FT MICA*043, allele MICA*044, allele FT MICA*045, allele MICA*046, allele FT MICA*047, allele MICA*048, allele FT MICA*049, allele MICA*051, allele FT MICA*052, allele MICA*053, allele FT MICA*054, allele MICA*055 and allele FT MICA*056; dbSNP:rs1051791). FT /FTId=VAR_043635. FT VARIANT 152 152 M -> V (in allele MICA*004, allele FT MICA*005, allele MICA*006, allele FT MICA*008, allele MICA*009, allele FT MICA*010, allele MICA*013, allele FT MICA*016, allele MICA*019, allele FT MICA*022, allele MICA*024, allele FT MICA*027, allele MICA*028, allele FT MICA*033, allele MICA*044, allele FT MICA*048, allele MICA*049, allele FT MICA*053, allele MICA*054 and allele FT MICA*056; reduces binding affinity for FT KLRK1; dbSNP:rs1051792). FT /FTId=VAR_043636. FT VARIANT 165 165 V -> I (in allele MICA*029; FT dbSNP:rs3819269). FT /FTId=VAR_043637. FT VARIANT 174 174 M -> V (in allele MICA*011 and allele FT MICA*034; dbSNP:rs41560824). FT /FTId=VAR_043638. FT VARIANT 179 179 H -> L (in allele MICA*012, allele FT MICA*032 and allele MICA*043; FT dbSNP:rs3819268). FT /FTId=VAR_043639. FT VARIANT 196 196 K -> E (in allele MICA*004, allele FT MICA*006, allele MICA*008, allele FT MICA*009, allele MICA*010, allele FT MICA*013, allele MICA*014, allele FT MICA*016, allele MICA*019, allele FT MICA*022, allele MICA*024, allele FT MICA*027, allele MICA*028, allele FT MICA*033, allele MICA*036, allele FT MICA*044, allele MICA*048, allele FT MICA*049, allele MICA*053, allele FT MICA*054 and allele MICA*056; FT dbSNP:rs1051794). FT /FTId=VAR_043640. FT VARIANT 198 198 G -> S (in allele MICA*004, allele FT MICA*006, allele MICA*009, allele FT MICA*010, allele MICA*016, allele FT MICA*019, allele MICA*031, allele FT MICA*033, allele MICA*036, allele FT MICA*044, allele MICA*049, allele FT MICA*054 and allele MICA*056; FT dbSNP:rs1131896). FT /FTId=VAR_043641. FT VARIANT 199 199 V -> I (in allele MICA*006; FT dbSNP:rs41549718). FT /FTId=VAR_043642. FT VARIANT 204 204 T -> R (in allele MICA*004, allele FT MICA*014, allele MICA*032 and allele FT MICA*044; dbSNP:rs1131897). FT /FTId=VAR_043643. FT VARIANT 229 229 G -> S (in allele MICA*004, allele FT MICA*005, allele MICA*006, allele FT MICA*008, allele MICA*009, allele FT MICA*010, allele MICA*016, allele FT MICA*019, allele MICA*022, allele FT MICA*024, allele MICA*027, allele FT MICA*033, allele MICA*034, allele FT MICA*035, allele MICA*037, allele FT MICA*038, allele MICA*039, allele FT MICA*042, allele MICA*044, allele FT MICA*048, allele MICA*049, allele FT MICA*053, allele MICA*054 and allele FT MICA*056; dbSNP:rs1131898). FT /FTId=VAR_043644. FT VARIANT 231 231 Y -> C (in allele MICA*046; FT dbSNP:rs41546915). FT /FTId=VAR_043645. FT VARIANT 233 233 W -> R (in allele MICA*004, allele FT MICA*005, allele MICA*006, allele FT MICA*008, allele MICA*009, allele FT MICA*010, allele MICA*016, allele FT MICA*019, allele MICA*022, allele FT MICA*024, allele MICA*027, allele FT MICA*033, allele MICA*034, allele FT MICA*035, allele MICA*037, allele FT MICA*038, allele MICA*039, allele FT MICA*042, allele MICA*044, allele FT MICA*048, allele MICA*049, allele FT MICA*053, allele MICA*054 and allele FT MICA*056; dbSNP:rs1051798). FT /FTId=VAR_043646. FT VARIANT 236 236 T -> I (in allele MICA*008, allele FT MICA*010, allele MICA*016, allele FT MICA*019, allele MICA*022, allele FT MICA*027, allele MICA*033, allele FT MICA*035, allele MICA*037, allele FT MICA*039, allele MICA*042, allele FT MICA*048, allele MICA*053, allele FT MICA*054 and allele MICA*056; FT dbSNP:rs1140700). FT /FTId=VAR_043647. FT VARIANT 238 238 S -> T (in allele MICA*004, allele FT MICA*006, allele MICA*008, allele FT MICA*009, allele MICA*010, allele FT MICA*016, allele MICA*019, allele FT MICA*022, allele MICA*024, allele FT MICA*027, allele MICA*033, allele FT MICA*034, allele MICA*035, allele FT MICA*037, allele MICA*038, allele FT MICA*039, allele MICA*042, allele FT MICA*044, allele MICA*048, allele FT MICA*049, allele MICA*053, allele FT MICA*054 and allele MICA*056; FT dbSNP:rs1051799). FT /FTId=VAR_043648. FT VARIANT 244 244 V -> L (in allele MICA*016 and allele FT MICA*039; dbSNP:rs41540613). FT /FTId=VAR_043649. FT VARIANT 253 253 W -> S (in allele MICA*056; FT dbSNP:rs72558175). FT /FTId=VAR_043869. FT VARIANT 274 274 Q -> R (in allele MICA*005, allele FT MICA*008, allele MICA*010, allele FT MICA*013, allele MICA*016, allele FT MICA*019, allele MICA*022, allele FT MICA*027, allele MICA*033, allele FT MICA*035, allele MICA*037, allele FT MICA*039, allele MICA*042, allele FT MICA*045, allele MICA*048, allele FT MICA*053, allele MICA*054 and allele FT MICA*056; dbSNP:rs1063635). FT /FTId=VAR_043650. FT VARIANT 279 279 R -> S (in allele MICA*043; FT dbSNP:rs41557614). FT /FTId=VAR_043651. FT VARIANT 291 291 S -> G (in allele MICA*054; FT dbSNP:rs61759927). FT /FTId=VAR_043652. FT VARIANT 294 294 P -> A (in allele MICA*011, allele FT MICA*030 and allele MICA*047; FT dbSNP:rs41553616). FT /FTId=VAR_043653. FT VARIANT 300 383 VLVLQSHWQTFHVSAVAAAAIFVIIIFYVRCCKKKTSAAEG FT PELVSLQVLDQHPVGTSDHRDATQLGFQPLMSDLGSTGSTE FT GA -> CWCFRVIGRHSMFLLLLLLLLLLLLFLLLLFSTSV FT VVRRKHQLQRVQSS (in allele MICA*015 and FT allele MICA*017). FT /FTId=VAR_043654. FT VARIANT 318 383 AAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQHPVGTSD FT HRDATQLGFQPLMSDLGSTGSTEGA -> GCCYFCYYYFLC FT PLL (in allele MICA*008, allele MICA*023, FT allele MICA*028 and allele MICA*053). FT /FTId=VAR_043655. FT VARIANT 319 319 A -> AA (in allele MICA*010, allele FT MICA*016, allele MICA*019, allele FT MICA*027, allele MICA*033, allele FT MICA*048, allele MICA*054 and allele FT MICA*056). FT /FTId=VAR_043656. FT VARIANT 319 319 A -> AAA (in allele MICA*004, allele FT MICA*006, allele MICA*009, allele FT MICA*011, allele MICA*026, allele FT MICA*047 and allele MICA*049). FT /FTId=VAR_043657. FT VARIANT 319 319 A -> AAAA (in allele MICA*050). FT /FTId=VAR_043658. FT VARIANT 319 319 A -> AAAAA (in allele MICA*055). FT /FTId=VAR_043659. FT VARIANT 319 319 A -> AAAAAA (in allele MICA*002, allele FT MICA*041, allele MICA*046 and allele FT MICA*052). FT /FTId=VAR_043660. FT VARIANT 319 319 A -> AAAAAAA (in allele MICA*020). FT /FTId=VAR_043661. FT VARIANT 328 328 V -> I (in allele MICA*052; FT dbSNP:rs72558178). FT /FTId=VAR_043662. FT VARIANT 329 329 R -> C (in allele MICA*002, allele FT MICA*011, allele MICA*020, allele FT MICA*041, allele MICA*043, allele FT MICA*046, allele MICA*047, allele FT MICA*050 and allele MICA*052; FT dbSNP:rs41554412). FT /FTId=VAR_043663. FT VARIANT 356 356 T -> M (in allele MICA*049; FT dbSNP:rs41546114). FT /FTId=VAR_043664. FT VARIANT 373 373 D -> A (in allele MICA*004, allele FT MICA*006, allele MICA*010, allele FT MICA*011, allele MICA*016, allele FT MICA*019, allele MICA*048 and allele FT MICA*049; dbSNP:rs9266825). FT /FTId=VAR_043665. FT VARIANT 377 377 T -> A (in allele MICA*011; FT dbSNP:rs41545814). FT /FTId=VAR_043666. FT VARIANT 383 383 A -> T (in allele MICA*018; FT dbSNP:rs1882). FT /FTId=VAR_043667. FT STRAND 26 37 {ECO:0000244|PDB:1HYR}. FT STRAND 40 51 {ECO:0000244|PDB:1HYR}. FT STRAND 54 59 {ECO:0000244|PDB:1HYR}. FT STRAND 64 66 {ECO:0000244|PDB:1HYR}. FT STRAND 71 75 {ECO:0000244|PDB:1HYR}. FT HELIX 79 81 {ECO:0000244|PDB:1HYR}. FT HELIX 82 101 {ECO:0000244|PDB:1HYR}. FT STRAND 109 121 {ECO:0000244|PDB:1HYR}. FT STRAND 127 135 {ECO:0000244|PDB:1HYR}. FT STRAND 138 144 {ECO:0000244|PDB:1HYR}. FT TURN 145 148 {ECO:0000244|PDB:1HYR}. FT STRAND 149 151 {ECO:0000244|PDB:1HYR}. FT HELIX 156 170 {ECO:0000244|PDB:1HYR}. FT HELIX 177 196 {ECO:0000244|PDB:1HYR}. FT STRAND 208 213 {ECO:0000244|PDB:1HYR}. FT STRAND 217 233 {ECO:0000244|PDB:1HYR}. FT STRAND 236 241 {ECO:0000244|PDB:1HYR}. FT TURN 248 250 {ECO:0000244|PDB:1B3J}. FT STRAND 251 253 {ECO:0000244|PDB:1HYR}. FT STRAND 260 262 {ECO:0000244|PDB:1HYR}. FT STRAND 264 273 {ECO:0000244|PDB:1HYR}. FT HELIX 277 279 {ECO:0000244|PDB:1HYR}. FT STRAND 280 286 {ECO:0000244|PDB:1HYR}. FT STRAND 289 294 {ECO:0000244|PDB:1HYR}. SQ SEQUENCE 383 AA; 42915 MW; 1FE084813DDA13A8 CRC64; MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLTEVH LDGQPFLRCD RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL AHIKDQKEGL HSLQEIRVCE IHEDNSTRSS QHFYYDGELF LSQNLETKEW TMPQSSRAQT LAMNVRNFLK EDAMKTKTHY HAMHADCLQE LRRYLKSGVV LRRTVPPMVN VTRSEASEGN ITVTCRASGF YPWNITLSWR QDGVSLSHDT QQWGDVLPDG NGTYQTWVAT RICQGEEQRF TCYMEHSGNH STHPVPSGKV LVLQSHWQTF HVSAVAAAAI FVIIIFYVRC CKKKTSAAEG PELVSLQVLD QHPVGTSDHR DATQLGFQPL MSDLGSTGST EGA // ID MICB_HUMAN Reviewed; 383 AA. AC Q29980; A2AC57; A6NP85; B0UZ10; B2RAK2; O14499; O14500; O19798; AC O19799; O19800; O19801; O19802; O19803; O78099; O78100; O78101; AC O78102; O78103; O78104; P79525; P79541; Q5GR31; Q5GR37; Q5GR41; AC Q5GR42; Q5GR43; Q5GR44; Q5GR46; Q5GR48; Q5RIY6; Q5SSK1; Q5ST25; AC Q7JK51; Q7YQ89; Q861E6; Q9MY18; Q9MY19; Q9MY20; Q9UBH4; Q9UBZ8; AC Q9UEJ0; DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 12-SEP-2018, entry version 148. DE RecName: Full=MHC class I polypeptide-related sequence B; DE Short=MIC-B; DE Flags: Precursor; GN Name=MICB {ECO:0000312|EMBL:CAA62823.1}; GN Synonyms=PERB11.2 {ECO:0000312|EMBL:AAB51802.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] {ECO:0000305, ECO:0000312|EMBL:CAA62823.1} RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE MICB*001; ISOFORM 1). RX PubMed=8575823; DOI=10.1007/s002510050051; RA Bahram S., Spies T.; RT "Nucleotide sequence of a human MHC class I MICB cDNA."; RL Immunogenetics 43:230-233(1996). RN [2] {ECO:0000305, ECO:0000312|EMBL:AAB42011.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE MICB*002; ISOFORM 1). RX PubMed=8952966; DOI=10.1007/s002510050184; RA Bahram S., Shiina T., Oka A., Tamiya G., Inoko H.; RT "Genomic structure of the human MHC class I MICB gene."; RL Immunogenetics 45:161-162(1996). RN [3] {ECO:0000305, ECO:0000312|EMBL:ABO16470.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE MICB*005; ISOFORM 1), AND RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). RX PubMed=17678727; DOI=10.1016/j.humimm.2007.05.003; RA Martinez-Borra J., Rodrigo L., Rodriguez-Rodero S., RA Fernandez-Morera J.L., Diaz-Pena R., Pruneda L., Lopez-Vazquez A., RA Lopez-Larrea C.; RT "The allele MICB*0050204, over-represented in the Caucasian RT population, has an additional exon resulting from a new splice RT junction sequence."; RL Hum. Immunol. 68:705-707(2007). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS RP GLY-39; GLU-80; ASN-136 AND ALA-300. RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] {ECO:0000305, ECO:0000312|EMBL:BAB63307.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE MICB*002). RA Hirakawa M., Yamaguchi H., Imai K., Shimada J., Shiina S., Tamiya G., RA Oka A., Inoko H.; RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."; RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000305, ECO:0000312|EMBL:CAQ10628.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES MICB*002; RP MICB*003; MICB*004; MICB*005 AND MICB*008). RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS RP GLY-39; GLU-80 AND ALA-300. RC TISSUE=Pancreas; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] {ECO:0000305, ECO:0000312|EMBL:AAB51802.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-341 (ALLELE MICB*003; ISOFORM RP 1). RX PubMed=8995188; DOI=10.1007/s002510050191; RA Gaudieri S., Leelayuwat C., Townend D.C., Mullberg J., Cosman D., RA Dawkins R.L.; RT "Allelic and interlocus comparison of the PERB11 multigene family in RT the MHC."; RL Immunogenetics 45:209-216(1997). RN [9] {ECO:0000305, ECO:0000312|EMBL:AAB71642.1} RP NUCLEOTIDE SEQUENCE [MRNA] OF 24-341 (ALLELES MICB*002; MICB*003; RP MICB*004; MICB*005 AND MICB*006; ISOFORM 1). RX PubMed=9271635; DOI=10.1007/s002510050299; RA Pellet P., Renaud M., Fodil N., Laloux L., Inoko H., Hauptmann G., RA Debre P., Bahram S., Theodorou I.; RT "Allelic repertoire of the human MICB gene."; RL Immunogenetics 46:434-436(1997). RN [10] {ECO:0000305, ECO:0000312|EMBL:CAD91554.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-341 (ALLELE MICB*015; ISOFORM RP 1). RC TISSUE=Blood {ECO:0000312|EMBL:CAD91554.1}; RX PubMed=15191526; DOI=10.1111/j.1399-0039.2004.00242.x; RA Quiroga I., Sweeney D., Sutton P.M., Chapple S.D.J., RA Souto-Grando J.P., Barnardo M.C.N.M., Fuggle S.V.; RT "A novel major histocompatibility complex class I-related chain RT allele."; RL Tissue Antigens 64:74-77(2004). RN [11] {ECO:0000305, ECO:0000312|EMBL:AAC39847.1} RP NUCLEOTIDE SEQUENCE [MRNA] OF 25-383 (ALLELES MICB*002; MICB*005; RP MICB*008; MICB*010; MICB*011 AND MICB*012; ISOFORM 1). RX PubMed=9694358; DOI=10.1111/j.1399-0039.1998.tb03008.x; RA Visser C.J., Tilanus M.G., Schaeffer V., Tatari Z., Tamouza R., RA Janin A., Charron D.; RT "Sequencing-based typing reveals six novel MHC class I chain-related RT gene B (MICB) alleles."; RL Tissue Antigens 51:649-652(1998). RN [12] {ECO:0000305, ECO:0000312|EMBL:BAA23479.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICB*002; RP MICB*003; MICB*004; MICB*005; MICB*007 AND MICB*008; ISOFORM 1). RX PubMed=9321430; DOI=10.1007/s002510050311; RA Ando H., Mizuki N., Ota M., Yamazaki M., Ohno S., Goto K., Miyata Y., RA Wakisaka K., Bahram S., Inoko H.; RT "Allelic variants of the human MHC class I chain-related B gene RT (MICB)."; RL Immunogenetics 46:499-508(1997). RN [13] {ECO:0000305, ECO:0000312|EMBL:CAB72097.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICB*008; RP MICB*013 AND MICB*014; ISOFORM 1). RX PubMed=10746790; DOI=10.1034/j.1399-0039.2000.550210.x; RA Fischer G., Perez-Rodriguez M., Arguello J.R., Cox S.T., McWhinnie A., RA Travers P.J., Madrigal J.A.; RT "Three novel MICB alleles."; RL Tissue Antigens 55:166-170(2000). RN [14] {ECO:0000305, ECO:0000312|EMBL:CAE54939.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-297 (ALLELES MICB*005; RP MICB*014; MICB*016; MICB*018; MICB*019; MICB*020 AND MICB*022; ISOFORM RP 1). RX PubMed=15304008; DOI=10.1111/j.1399-0039.2004.00286.x; RA Schroeder M., Elsner H.-A., Kim T.D., Blasczyk R.; RT "Eight novel MICB alleles, including a null allele, identified in RT gastric MALT lymphoma patients."; RL Tissue Antigens 64:276-280(2004). RN [15] {ECO:0000305} RP FUNCTION, AND INDUCTION. RX PubMed=9497295; DOI=10.1126/science.279.5357.1737; RA Groh V., Steinle A., Bauer S., Spies T.; RT "Recognition of stress-induced MHC molecules by intestinal epithelial RT gammadelta T cells."; RL Science 279:1737-1740(1998). RN [16] {ECO:0000305} RP TISSUE SPECIFICITY. RX PubMed=10359807; DOI=10.1073/pnas.96.12.6879; RA Groh V., Rhinehart R., Secrist H., Bauer S., Grabstein K.H., Spies T.; RT "Broad tumor-associated expression and recognition by tumor-derived RT gamma delta T cells of MICA and MICB."; RL Proc. Natl. Acad. Sci. U.S.A. 96:6879-6884(1999). RN [17] {ECO:0000305} RP INDUCTION. RX PubMed=11287116; DOI=10.1016/S0304-4165(01)00099-X; RA Yamamoto K., Fujiyama Y., Andoh A., Bamba T., Okabe H.; RT "Oxidative stress increases MICA and MICB gene expression in the human RT colon carcinoma cell line (CaCo-2)."; RL Biochim. Biophys. Acta 1526:10-12(2001). RN [18] {ECO:0000305} RP INTERACTION WITH CYTOMEGALOVIRUS GLYCOPROTEIN UL16 (MICROBIAL RP INFECTION). RX PubMed=11239445; DOI=10.1016/S1074-7613(01)00095-4; RA Cosman D., Mullberg J., Sutherland C.L., Chin W., Armitage R., RA Fanslow W., Kubin M., Chalupny N.J.; RT "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein RT UL16 and stimulate NK cytotoxicity through the NKG2D receptor."; RL Immunity 14:123-133(2001). RN [19] {ECO:0000305} RP FUNCTION, AND INTERACTION WITH KLRK1. RX PubMed=11491531; DOI=10.1007/s002510100325; RA Steinle A., Li P., Morris D.L., Groh V., Lanier L.L., Strong R.K., RA Spies T.; RT "Interactions of human NKG2D with its ligands MICA, MICB, and homologs RT of the mouse RAE-1 protein family."; RL Immunogenetics 53:279-287(2001). RN [20] {ECO:0000305} RP ALTERNATIVE SPLICING. RX PubMed=12466900; DOI=10.1007/s00251-002-0496-y; RA Zou Y., Stastny P.; RT "Alternatively spliced forms of MICA and MICB lacking exon 3 in a RT human cell line and evidence of presence of similar RNA in human RT peripheral blood mononuclear cells."; RL Immunogenetics 54:671-674(2002). RN [21] RP FUNCTION AS A LIGAND FOR KLRK1. RX PubMed=11777960; DOI=10.4049/jimmunol.168.2.671; RA Sutherland C.L., Chalupny N.J., Schooley K., VandenBos T., Kubin M., RA Cosman D.; RT "UL16-binding proteins, novel MHC class I-related proteins, bind to RT NKG2D and activate multiple signaling pathways in primary NK cells."; RL J. Immunol. 168:671-679(2002). RN [22] {ECO:0000305} RP TISSUE SPECIFICITY, AND INDUCTION. RX PubMed=12569559; DOI=10.1002/ijc.10966; RA Jinushi M., Takehara T., Tatsumi T., Kanto T., Groh V., Spies T., RA Kimura R., Miyagi T., Mochizuki K., Sasaki Y., Hayashi N.; RT "Expression and role of MICA and MICB in human hepatocellular RT carcinomas and their regulation by retinoic acid."; RL Int. J. Cancer 104:354-361(2003). RN [23] {ECO:0000305} RP INTERACTION WITH CYTOMEGALOVIRUS GLYCOPROTEIN UL16, AND SUBCELLULAR RP LOCATION. RX PubMed=12782710; DOI=10.1084/jem.20022059; RA Dunn C., Chalupny N.J., Sutherland C.L., Dosch S., Sivakumar P.V., RA Johnson D.C., Cosman D.; RT "Human cytomegalovirus glycoprotein UL16 causes intracellular RT sequestration of NKG2D ligands, protecting against natural killer cell RT cytotoxicity."; RL J. Exp. Med. 197:1427-1439(2003). RN [24] {ECO:0000305} RP INDUCTION. RX PubMed=12538683; DOI=10.4049/jimmunol.170.3.1249; RA Jinushi M., Takehara T., Kanto T., Tatsumi T., Groh V., Spies T., RA Miyagi T., Suzuki T., Sasaki Y., Hayashi N.; RT "Critical role of MHC class I-related chain A and B expression on IFN- RT alpha-stimulated dendritic cells in NK cell activation: impairment in RT chronic hepatitis C virus infection."; RL J. Immunol. 170:1249-1256(2003). RN [25] {ECO:0000305} RP PROTEOLYTIC CLEAVAGE ON TUMOR CELLS. RX PubMed=16698441; DOI=10.1016/j.humimm.2006.02.008; RA Salih H.R., Goehlsdorf D., Steinle A.; RT "Release of MICB molecules by tumor cells: mechanism and soluble MICB RT in sera of cancer patients."; RL Hum. Immunol. 67:188-195(2006). RN [26] {ECO:0000305} RP INTERACTION WITH KLRK1. RX PubMed=16849432; DOI=10.1073/pnas.0600721103; RA Roda-Navarro P., Vales-Gomez M., Chisholm S.E., Reyburn H.T.; RT "Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse RT correlates with a reduction in NK cell cytotoxic function."; RL Proc. Natl. Acad. Sci. U.S.A. 103:11258-11263(2006). RN [27] {ECO:0000305} RP TISSUE SPECIFICITY. RX PubMed=17565371; DOI=10.1371/journal.pone.0000518; RA Schrambach S., Ardizzone M., Leymarie V., Sibilia J., Bahram S.; RT "In vivo expression pattern of MICA and MICB and its relevance to RT auto-immunity and cancer."; RL PLoS ONE 2:E518-E518(2007). RN [28] {ECO:0000305} RP INVOLVEMENT IN RHEUMATOID ARTHRITIS. RX PubMed=17003176; DOI=10.1093/rheumatology/kel331; RA Lopez-Arbesu R., Ballina-Garcia F.J., Alperi-Lopez M., Lopez-Soto A., RA Rodriguez-Rodero S., Martinez-Borra J., Lopez-Vazquez A., RA Fernandez-Morera J.L., Riestra-Noriega J.L., Queiro-Silva R., RA Quinones-Lombrana A., Lopez-Larrea C., Gonzalez S.; RT "MHC class I chain-related gene B (MICB) is associated with rheumatoid RT arthritis susceptibility."; RL Rheumatology 46:426-430(2007). RN [29] {ECO:0000305} RP INVOLVEMENT IN SCHIZOPHRENIA. RX PubMed=17561376; DOI=10.1016/j.schres.2007.04.021; RA Shirts B.H., Kim J.J., Reich S., Dickerson F.B., Yolken R.H., RA Devlin B., Nimgaonkar V.L.; RT "Polymorphisms in MICB are associated with human herpes virus RT seropositivity and schizophrenia risk."; RL Schizophr. Res. 94:342-353(2007). RN [30] {ECO:0000305} RP INDUCTION. RX PubMed=17641203; DOI=10.1126/science.1140956; RA Stern-Ginossar N., Elefant N., Zimmermann A., Wolf D.G., Saleh N., RA Biton M., Horwitz E., Prokocimer Z., Prichard M., Hahn G., RA Goldman-Wohl D., Greenfield C., Yagel S., Hengel H., Altuvia Y., RA Margalit H., Mandelboim O.; RT "Host immune system gene targeting by a viral miRNA."; RL Science 317:376-381(2007). RN [31] {ECO:0000305} RP INDUCTION. RX PubMed=18395517; DOI=10.1016/j.bbrc.2008.03.131; RA Tang K.-F., He C.-X., Zeng G.-L., Wu J., Song G.-B., Shi Y.-S., RA Zhang W.-G., Huang A.-L., Steinle A., Ren H.; RT "Induction of MHC class I-related chain B (MICB) by 5-aza-2'- RT deoxycytidine."; RL Biochem. Biophys. Res. Commun. 370:578-583(2008). RN [32] {ECO:0000305} RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 24-297, AND DISULFIDE BONDS. RX PubMed=12133964; DOI=10.4049/jimmunol.169.3.1395; RA Holmes M.A., Li P., Petersdorf E.W., Strong R.K.; RT "Structural studies of allelic diversity of the MHC class I homolog RT MIC-B, a stress-inducible ligand for the activating immunoreceptor RT NKG2D."; RL J. Immunol. 169:1395-1400(2002). CC -!- FUNCTION: Seems to have no role in antigen presentation. Acts as a CC stress-induced self-antigen that is recognized by gamma delta T CC cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads CC to cell lysis. {ECO:0000269|PubMed:11491531, CC ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:9497295}. CC -!- SUBUNIT: Unlike classical MHC class I molecules, does not form a CC heterodimer with beta-2-microglobulin. Binds as a monomer to a CC KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in CC which KLRK1 binds MICB while HCST acts as an adapter molecule CC which enables signal transduction. Receptor-ligand interaction CC induces clustering of both proteins in ordered structures called CC immune synapses and also leads to their intercellular transfer. CC This is associated with a reduction in the cytotoxicity of KLRK1- CC expressing cells. {ECO:0000250|UniProtKB:Q29983, CC ECO:0000269|PubMed:11239445, ECO:0000269|PubMed:11491531, CC ECO:0000269|PubMed:12782710, ECO:0000269|PubMed:16849432}. CC -!- SUBUNIT: (Microbial infection) Interacts with human CC cytomegalovirus/HHV-5 glycoprotein UL16; this interaction causes CC sequestration of MICB in the endoplasmic reticulum and increases CC resistance to KLRK1-mediated cytotoxicity. CC {ECO:0000269|PubMed:11239445}. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000250|UniProtKB:Q29983}; Single-pass type I membrane CC protein {ECO:0000250|UniProtKB:Q29983}. Note=Binding to human CC cytomegalovirus glycoprotein UL16 causes sequestration in the CC endoplasmic reticulum. {ECO:0000250|UniProtKB:Q29983, CC ECO:0000269|PubMed:12782710}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1 {ECO:0000269|PubMed:12466900}; Synonyms=MICB1 CC {ECO:0000269|PubMed:12466900}; CC IsoId=Q29980-1; Sequence=Displayed; CC Name=2 {ECO:0000269|PubMed:12466900}; Synonyms=MICB2 CC {ECO:0000269|PubMed:12466900}, ex3-del; CC IsoId=Q29980-2; Sequence=VSP_055246; CC Name=3 {ECO:0000269|PubMed:17678727}; CC IsoId=Q29980-3; Sequence=VSP_052801, VSP_052802; CC Note=A GC to AG nucleotide substitution in intron 1 generates a CC splice junction which gives rise to an additional exon between CC exons 1 and 2. May be produced at very low levels due to a CC premature stop codon in the mRNA, leading to nonsense-mediated CC mRNA decay.; CC -!- TISSUE SPECIFICITY: Widely expressed with the exception of the CC central nervous system where it is absent. Expressed in many, but CC not all, epithelial tumors of lung, breast, kidney, ovary, CC prostate and colon. In hepatocellular carcinomas, expressed in CC tumor cells but not in surrounding non-cancerous tissue. CC {ECO:0000269|PubMed:10359807, ECO:0000269|PubMed:12569559, CC ECO:0000269|PubMed:17565371}. CC -!- INDUCTION: By heat shock, oxidative stress, retinoic acid, IFN- CC alpha and the DNA methyltransferase inhibitor 5-aza-2'- CC deoxycytidine. Induction by IFN-alpha is impaired in patients with CC chronic hepatitis C virus infection. Down-regulated by human CC cytomegalovirus UL112 microRNA during viral infection which leads CC to decreased binding of KLRK1/NKG2D and reduced killing by natural CC killer cells. {ECO:0000269|PubMed:11287116, CC ECO:0000269|PubMed:12538683, ECO:0000269|PubMed:12569559, CC ECO:0000269|PubMed:17641203, ECO:0000269|PubMed:18395517, CC ECO:0000269|PubMed:9497295}. CC -!- PTM: Proteolytically cleaved and released from the cell surface of CC tumor cells. {ECO:0000269|PubMed:16698441}. CC -!- POLYMORPHISM: The following alleles of MICB are known: MICB*001, CC MICB*002, MICB*003, MICB*004, MICB*005, MICB*006, MICB*007, CC MICB*008, MICB*009N, MICB*010, MICB*011, MICB*012, MICB*013, CC MICB*014, MICB*015, MICB*016, MICB*018, MICB*019, MICB*020, CC MICB*021N and MICB*022. MICB*009N and MICB*021N are null alleles CC which are not expressed. The sequence shown is that of MICB*001. CC {ECO:0000305}. CC -!- DISEASE: Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory CC disease with autoimmune features and a complex genetic component. CC It primarily affects the joints and is characterized by CC inflammatory changes in the synovial membranes and articular CC structures, widespread fibrinoid degeneration of the collagen CC fibers in mesenchymal tissues, and by atrophy and rarefaction of CC bony structures. {ECO:0000269|PubMed:17003176}. Note=Disease CC susceptibility is associated with variations affecting the gene CC represented in this entry. The MICB*004 allele is associated with CC rheumatoid arthritis. CC -!- DISEASE: Note=Genetic variation in MICB is associated with CC cytomegalovirus and herpes simplex virus I seropositivity and this CC may be associated with schizophrenia risk. CC -!- SIMILARITY: Belongs to the MHC class I family. MIC subfamily. CC {ECO:0000255}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X91625; CAA62823.1; -; mRNA. DR EMBL; U65416; AAB42011.1; -; Genomic_DNA. DR EMBL; AY885251; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; EF051579; ABO16470.1; -; Genomic_DNA. DR EMBL; EF051580; ABO16471.1; -; Genomic_DNA. DR EMBL; AK314228; BAG36899.1; -; mRNA. DR EMBL; BA000025; BAB63307.1; -; Genomic_DNA. DR EMBL; AL662866; CAI17555.1; -; Genomic_DNA. DR EMBL; AL663061; CAI18082.1; -; Genomic_DNA. DR EMBL; BX001040; CAI18629.1; -; Genomic_DNA. DR EMBL; BX005439; CAI18747.1; -; Genomic_DNA. DR EMBL; CR753820; CAQ07170.1; -; Genomic_DNA. DR EMBL; CR753864; CAQ10628.1; -; Genomic_DNA. DR EMBL; CR788288; CAQ09224.1; -; Genomic_DNA. DR EMBL; BC044218; AAH44218.1; -; mRNA. DR EMBL; U69978; AAB51802.1; -; Genomic_DNA. DR EMBL; U95729; AAB71642.1; -; mRNA. DR EMBL; U95730; AAB71643.1; -; mRNA. DR EMBL; U95731; AAB71644.1; -; mRNA. DR EMBL; U95732; AAB71645.1; -; mRNA. DR EMBL; U95733; AAB71646.1; -; mRNA. DR EMBL; U95734; AAB71647.1; -; mRNA. DR EMBL; AJ563706; CAD91554.1; -; Genomic_DNA. DR EMBL; AF021221; AAC39846.1; -; mRNA. DR EMBL; AF021222; AAC39847.1; -; mRNA. DR EMBL; AF021223; AAC39848.1; -; mRNA. DR EMBL; AF021224; AAC39849.1; -; mRNA. DR EMBL; AF021225; AAC39850.1; -; mRNA. DR EMBL; AF021226; AAC39851.1; -; mRNA. DR EMBL; AB003609; BAA23476.1; -; Genomic_DNA. DR EMBL; AB003610; BAA23477.1; -; Genomic_DNA. DR EMBL; AB003611; BAA23478.1; -; Genomic_DNA. DR EMBL; AB003612; BAA23479.1; -; Genomic_DNA. DR EMBL; AB003613; BAA23480.1; -; Genomic_DNA. DR EMBL; AB003614; BAA23481.1; -; Genomic_DNA. DR EMBL; AB003615; BAA23482.1; -; Genomic_DNA. DR EMBL; AB003616; BAA23483.1; -; Genomic_DNA. DR EMBL; AB003617; BAA23484.1; -; Genomic_DNA. DR EMBL; AJ251156; CAB72101.1; -; Genomic_DNA. DR EMBL; AJ251157; CAB72101.1; JOINED; Genomic_DNA. DR EMBL; AJ251158; CAB72097.1; -; Genomic_DNA. DR EMBL; AJ251159; CAB72097.1; JOINED; Genomic_DNA. DR EMBL; AJ251160; CAB72098.1; -; Genomic_DNA. DR EMBL; AJ251161; CAB72098.1; JOINED; Genomic_DNA. DR EMBL; AJ606906; CAE54932.1; -; Genomic_DNA. DR EMBL; AJ606907; CAE54933.1; -; Genomic_DNA. DR EMBL; AJ606908; CAE54934.1; -; Genomic_DNA. DR EMBL; AJ606909; CAE54935.1; -; Genomic_DNA. DR EMBL; AJ606910; CAE54936.1; -; Genomic_DNA. DR EMBL; AJ606911; CAE54937.1; -; Genomic_DNA. DR EMBL; AJ606912; CAE54938.1; -; Genomic_DNA. DR EMBL; AJ606913; CAE54939.1; -; Genomic_DNA. DR EMBL; AJ606914; CAE54940.1; -; Genomic_DNA. DR EMBL; AJ606915; CAE54941.1; -; Genomic_DNA. DR EMBL; AJ606916; CAE54942.1; -; Genomic_DNA. DR EMBL; AJ606917; CAE54943.1; -; Genomic_DNA. DR EMBL; AJ606918; CAE54944.1; -; Genomic_DNA. DR EMBL; AJ606919; CAE54945.1; -; Genomic_DNA. DR EMBL; AJ606920; CAE54946.1; -; Genomic_DNA. DR EMBL; AJ606921; CAE54947.1; -; Genomic_DNA. DR EMBL; AJ606922; CAE54948.1; -; Genomic_DNA. DR EMBL; AJ606923; CAE54949.1; -; Genomic_DNA. DR EMBL; AJ606929; CAE54955.1; -; Genomic_DNA. DR EMBL; AJ606930; CAE54956.1; -; Genomic_DNA. DR EMBL; AJ606931; CAE54957.1; -; Genomic_DNA. DR RefSeq; NP_001276089.1; NM_001289160.1. DR RefSeq; NP_001276090.1; NM_001289161.1. DR RefSeq; NP_005922.2; NM_005931.4. DR UniGene; Hs.731446; -. DR PDB; 1JE6; X-ray; 2.50 A; A=24-297. DR PDB; 2WY3; X-ray; 1.80 A; A/C=24-341. DR PDBsum; 1JE6; -. DR PDBsum; 2WY3; -. DR ProteinModelPortal; Q29980; -. DR SMR; Q29980; -. DR BioGrid; 110424; 45. DR CORUM; Q29980; -. DR STRING; 9606.ENSP00000252229; -. DR iPTMnet; Q29980; -. DR PhosphoSitePlus; Q29980; -. DR SwissPalm; Q29980; -. DR BioMuta; MICB; -. DR DMDM; 74706857; -. DR MaxQB; Q29980; -. DR PaxDb; Q29980; -. DR PeptideAtlas; Q29980; -. DR PRIDE; Q29980; -. DR ProteomicsDB; 61282; -. DR ProteomicsDB; 61283; -. [Q29980-3] DR Ensembl; ENST00000399150; ENSP00000382103; ENSG00000204516. DR Ensembl; ENST00000427115; ENSP00000395391; ENSG00000204516. DR Ensembl; ENST00000428416; ENSP00000398412; ENSG00000206449. DR Ensembl; ENST00000436531; ENSP00000409414; ENSG00000238289. DR Ensembl; ENST00000436655; ENSP00000402484; ENSG00000238289. DR Ensembl; ENST00000438954; ENSP00000398212; ENSG00000234218. DR Ensembl; ENST00000443156; ENSP00000393355; ENSG00000227772. DR Ensembl; ENST00000546706; ENSP00000449672; ENSG00000231179. DR Ensembl; ENST00000551608; ENSP00000447696; ENSG00000224378. DR GeneID; 4277; -. DR KEGG; hsa:4277; -. DR UCSC; uc003nto.6; human. [Q29980-1] DR CTD; 4277; -. DR DisGeNET; 4277; -. DR EuPathDB; HostDB:ENSG00000204516.9; -. DR GeneCards; MICB; -. DR H-InvDB; HIX0057971; -. DR HGNC; HGNC:7091; MICB. DR HPA; HPA064618; -. DR MIM; 180300; phenotype. DR MIM; 602436; gene. DR neXtProt; NX_Q29980; -. DR PharmGKB; PA30812; -. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR HOGENOM; HOG000231246; -. DR HOVERGEN; HBG106364; -. DR InParanoid; Q29980; -. DR KO; K07985; -. DR OrthoDB; EOG091G0ANY; -. DR PhylomeDB; Q29980; -. DR TreeFam; TF342166; -. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR ChiTaRS; MICB; human. DR EvolutionaryTrace; Q29980; -. DR GenomeRNAi; 4277; -. DR PRO; PR:Q29980; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204516; Expressed in 172 organ(s), highest expression level in blood. DR ExpressionAtlas; Q29980; baseline and differential. DR Genevisible; Q29980; HS. DR GO; GO:0009986; C:cell surface; ISS:UniProtKB. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IDA:UniProtKB. DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW. DR GO; GO:0046629; P:gamma-delta T cell activation; IDA:UniProtKB. DR GO; GO:0002429; P:immune response-activating cell surface receptor signaling pathway; IDA:UniProtKB. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0050689; P:negative regulation of defense response to virus by host; IDA:UniProtKB. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0009408; P:response to heat; IDA:UniProtKB. DR GO; GO:0006979; P:response to oxidative stress; IDA:UniProtKB. DR GO; GO:0032526; P:response to retinoic acid; IDA:UniProtKB. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0016032; P:viral process; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW 3D-structure; Adaptive immunity; Alternative splicing; Cell membrane; KW Complete proteome; Cytolysis; Disulfide bond; Glycoprotein; KW Host-virus interaction; Immunity; Immunoglobulin domain; Membrane; KW Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 22 {ECO:0000255}. FT CHAIN 23 383 MHC class I polypeptide-related sequence FT B. {ECO:0000255}. FT /FTId=PRO_0000341418. FT TOPO_DOM 23 309 Extracellular. {ECO:0000255}. FT TRANSMEM 310 330 Helical. {ECO:0000255}. FT TOPO_DOM 331 383 Cytoplasmic. {ECO:0000255}. FT DOMAIN 207 298 Ig-like C1-type. {ECO:0000255}. FT CARBOHYD 164 164 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 210 210 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 220 220 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 261 261 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 119 187 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:12133964}. FT DISULFID 225 282 {ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:12133964}. FT VAR_SEQ 24 41 EPHSLRYNLMVLSQDESV -> VEMGFHRVSQDGLDLLTS FT (in isoform 3). FT {ECO:0000303|PubMed:17678727}. FT /FTId=VSP_052801. FT VAR_SEQ 42 383 Missing (in isoform 3). FT {ECO:0000303|PubMed:17678727}. FT /FTId=VSP_052802. FT VAR_SEQ 109 151 Missing (in isoform 2). FT {ECO:0000303|PubMed:15489334}. FT /FTId=VSP_055246. FT VARIANT 39 39 E -> G (in allele MICB*002, allele FT MICB*003, allele MICB*004, allele FT MICB*005, allele MICB*006, allele FT MICB*007, allele MICB*008, allele FT MICB*010, allele MICB*011, allele FT MICB*012, allele MICB*013, allele FT MICB*014, allele MICB*015, allele FT MICB*016, allele MICB*018, allele FT MICB*019, allele MICB*020 and allele FT MICB*022; dbSNP:rs45578846). FT {ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334}. FT /FTId=VAR_044068. FT VARIANT 68 68 P -> H (in allele MICB*011; FT dbSNP:rs45583740). FT /FTId=VAR_044069. FT VARIANT 75 75 D -> N (in allele MICB*004 and allele FT MICB*020; dbSNP:rs3131639). FT /FTId=VAR_044070. FT VARIANT 80 80 K -> E (in allele MICB*002, allele FT MICB*007, allele MICB*008, allele FT MICB*014, allele MICB*015, allele FT MICB*016, allele MICB*019 and allele FT MICB*022; dbSNP:rs1065075). FT {ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334}. FT /FTId=VAR_044071. FT VARIANT 88 88 D -> G (in allele MICB*022; FT dbSNP:rs45486091). FT /FTId=VAR_044072. FT VARIANT 105 105 D -> G (in allele MICB*012; FT dbSNP:rs45502297). FT /FTId=VAR_044073. FT VARIANT 121 121 I -> M (in allele MICB*008; FT dbSNP:rs3134900). FT /FTId=VAR_044074. FT VARIANT 136 136 D -> H (in dbSNP:rs1051788). FT /FTId=VAR_059527. FT VARIANT 136 136 D -> N (in allele MICB*002, allele FT MICB*007, allele MICB*008, allele FT MICB*014, allele MICB*015, allele FT MICB*018, allele MICB*020 and allele FT MICB*022; dbSNP:rs1051788). FT {ECO:0000269|PubMed:14702039}. FT /FTId=VAR_044075. FT VARIANT 212 212 T -> I (in allele MICB*003; FT dbSNP:rs41293883). FT /FTId=VAR_044076. FT VARIANT 215 215 E -> K (in allele MICB*006 and allele FT MICB*015; dbSNP:rs45624537). FT /FTId=VAR_044077. FT VARIANT 279 279 R -> K (in allele MICB*007; FT dbSNP:rs45587032). FT /FTId=VAR_044078. FT VARIANT 291 291 G -> S (in allele MICB*013, allele FT MICB*014, allele MICB*015 and allele FT MICB*016; dbSNP:rs41273040). FT /FTId=VAR_044079. FT VARIANT 300 300 V -> A (in allele MICB*002, allele FT MICB*003, allele MICB*004, allele FT MICB*005, allele MICB*006, allele FT MICB*007, allele MICB*008, allele FT MICB*010, allele MICB*011, allele FT MICB*012, allele MICB*013, allele FT MICB*014 and allele MICB*015; FT dbSNP:rs45470602). FT {ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334}. FT /FTId=VAR_044080. FT VARIANT 383 383 A -> T (in allele MICB*003, allele FT MICB*004, allele MICB*010 and allele FT MICB*011; dbSNP:rs1065076). FT /FTId=VAR_044081. FT STRAND 26 37 {ECO:0000244|PDB:2WY3}. FT STRAND 46 51 {ECO:0000244|PDB:2WY3}. FT STRAND 54 60 {ECO:0000244|PDB:2WY3}. FT TURN 61 64 {ECO:0000244|PDB:2WY3}. FT STRAND 65 68 {ECO:0000244|PDB:2WY3}. FT HELIX 71 75 {ECO:0000244|PDB:2WY3}. FT HELIX 80 101 {ECO:0000244|PDB:2WY3}. FT STRAND 104 106 {ECO:0000244|PDB:1JE6}. FT STRAND 109 121 {ECO:0000244|PDB:2WY3}. FT STRAND 123 125 {ECO:0000244|PDB:1JE6}. FT STRAND 127 135 {ECO:0000244|PDB:2WY3}. FT STRAND 138 144 {ECO:0000244|PDB:2WY3}. FT TURN 145 147 {ECO:0000244|PDB:2WY3}. FT HELIX 156 170 {ECO:0000244|PDB:2WY3}. FT HELIX 176 197 {ECO:0000244|PDB:2WY3}. FT HELIX 201 203 {ECO:0000244|PDB:1JE6}. FT STRAND 208 214 {ECO:0000244|PDB:1JE6}. FT STRAND 218 233 {ECO:0000244|PDB:1JE6}. FT STRAND 236 241 {ECO:0000244|PDB:1JE6}. FT STRAND 250 253 {ECO:0000244|PDB:1JE6}. FT STRAND 264 273 {ECO:0000244|PDB:1JE6}. FT HELIX 277 279 {ECO:0000244|PDB:1JE6}. FT STRAND 280 286 {ECO:0000244|PDB:1JE6}. FT STRAND 289 294 {ECO:0000244|PDB:1JE6}. SQ SEQUENCE 383 AA; 42646 MW; 4291DAA55583F9DA CRC64; MGLGRVLLFL AVAFPFAPPA AAAEPHSLRY NLMVLSQDES VQSGFLAEGH LDGQPFLRYD RQKRRAKPQG QWAEDVLGAK TWDTETEDLT ENGQDLRRTL THIKDQKGGL HSLQEIRVCE IHEDSSTRGS RHFYYDGELF LSQNLETQES TVPQSSRAQT LAMNVTNFWK EDAMKTKTHY RAMQADCLQK LQRYLKSGVA IRRTVPPMVN VTCSEVSEGN ITVTCRASSF YPRNITLTWR QDGVSLSHNT QQWGDVLPDG NGTYQTWVAT RIRQGEEQRF TCYMEHSGNH GTHPVPSGKV LVLQSQRTDF PYVSAAMPCF VIIIILCVPC CKKKTSAAEG PELVSLQVLD QHPVGTGDHR DAAQLGFQPL MSATGSTGST EGA // ID ULBP1_HUMAN Reviewed; 244 AA. AC Q9BZM6; Q5VY81; Q8IZW3; Q8IZX6; DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 12-SEP-2018, entry version 138. DE RecName: Full=UL16-binding protein 1; DE AltName: Full=ALCAN-beta; DE AltName: Full=NKG2D ligand 1; DE Short=N2DL-1; DE Short=NKG2DL1; DE AltName: Full=Retinoic acid early transcript 1I; DE Flags: Precursor; GN Name=ULBP1; Synonyms=N2DL1, RAET1I; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND GPI-ANCHOR. RC TISSUE=B-cell lymphoma; RX PubMed=11239445; DOI=10.1016/S1074-7613(01)00095-4; RA Cosman D., Mullberg J., Sutherland C.L., Chin W., Armitage R., RA Fanslow W., Kubin M., Chalupny N.J.; RT "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein RT UL16 and stimulate NK cytotoxicity through the NKG2D receptor."; RL Immunity 14:123-133(2001). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Onda H., Shintani Y., Ohkubo S., Ogi K.; RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=11827464; DOI=10.1006/geno.2001.6673; RA Radosavljevic M., Cuillerier B., Wilson M.J., Clement O., Wicker S., RA Gilfillan S., Beck S., Trowsdale J., Bahram S.; RT "A cluster of ten novel MHC class I related genes on human chromosome RT 6q24.2-q25.3."; RL Genomics 79:114-123(2002). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Cerebellum, and Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] OF 6-244. RA Larson J.H., Rebeiz M., Stiening C.M., Windish R., Beever J.E., RA Lewin H.A.; RT "The ULBP proteins are highly divergent among mammals."; RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE [MRNA] OF 11-244. RX PubMed=11491531; DOI=10.1007/s002510100325; RA Steinle A., Li P., Morris D.L., Groh V., Lanier L.L., Strong R.K., RA Spies T.; RT "Interactions of human NKG2D with its ligands MICA, MICB, and homologs RT of the mouse RAE-1 protein family."; RL Immunogenetics 53:279-287(2001). RN [10] RP INTERACTION WITH CMV UL16, AND SUBCELLULAR LOCATION. RX PubMed=12782710; DOI=10.1084/jem.20022059; RA Dunn C., Chalupny N.J., Sutherland C.L., Dosch S., Sivakumar P.V., RA Johnson D.C., Cosman D.; RT "Human cytomegalovirus glycoprotein UL16 causes intracellular RT sequestration of NKG2D ligands, protecting against natural killer cell RT cytotoxicity."; RL J. Exp. Med. 197:1427-1439(2003). RN [11] RP FUNCTION, AND INTERACTION WITH KLRK1. RX PubMed=11777960; DOI=10.4049/jimmunol.168.2.671; RA Sutherland C.L., Chalupny N.J., Schooley K., VandenBos T., Kubin M., RA Cosman D.; RT "UL16-binding proteins, novel MHC class I-related proteins, bind to RT NKG2D and activate multiple signaling pathways in primary NK cells."; RL J. Immunol. 168:671-679(2002). RN [12] RP REVIEW. RX PubMed=12753652; DOI=10.1034/j.1399-0039.2003.00070.x; RA Cerwenka A., Lanier L.L.; RT "NKG2D ligands: unconventional MHC class I-like molecules exploited by RT viruses and cancer."; RL Tissue Antigens 61:335-343(2003). CC -!- FUNCTION: Binds and activates the KLRK1/NKG2D receptor, mediating CC natural killer cell cytotoxicity. {ECO:0000269|PubMed:11777960}. CC -!- SUBUNIT: Interacts with KLRK1/NKG2D (PubMed:11777960). Does not CC bind to beta2-microglobulin (PubMed:12782710). CC {ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:12782710}. CC -!- SUBUNIT: (Microbial infection) In CMV-infected cells, interacts CC with the viral glycoprotein UL16; this interaction causes ULBP1 CC retention in the endoplasmic reticulum and cis-Golgi and prevents CC binding to and activation of KLRK1/NKG2D, providing CMV with an CC immune evasion mechanism. {ECO:0000269|PubMed:12782710}. CC -!- INTERACTION: CC P26718:KLRK1; NbExp=2; IntAct=EBI-16365037, EBI-458344; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12782710}; CC Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12782710}. CC Endoplasmic reticulum {ECO:0000269|PubMed:12782710}. Note=In CMV- CC infected fibroblasts, detected in the endoplasmic reticulum/cis- CC Golgi. {ECO:0000269|PubMed:12782710}. CC -!- TISSUE SPECIFICITY: Expressed in T-cells, B-cells, erythroleukemia CC cell lines and in a wide range of tissues including heart, brain, CC lung, liver, testis, lymph node, thymus, tonsil and bone marrow. CC Also found in fetal heart, brain, lung and liver. CC -!- MISCELLANEOUS: UL16-binding proteins (ULBPs) are unusual members CC of the extended MHC class I superfamily. They do not contain the CC alpha 3 domain and lack a transmembrane domain. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AF304377; AAK13081.1; -; mRNA. DR EMBL; AB052907; BAB61049.1; -; mRNA. DR EMBL; AF346416; AAL76416.1; -; mRNA. DR EMBL; AK292519; BAF85208.1; -; mRNA. DR EMBL; AK316582; BAG38170.1; -; mRNA. DR EMBL; AL355497; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471051; EAW47776.1; -; Genomic_DNA. DR EMBL; BC035416; AAH35416.1; -; mRNA. DR EMBL; AF425265; AAN32759.1; -; mRNA. DR EMBL; AF346595; AAN40838.1; -; mRNA. DR CCDS; CCDS5223.1; -. DR RefSeq; NP_001304018.1; NM_001317089.1. DR RefSeq; NP_079494.1; NM_025218.3. DR UniGene; Hs.653255; -. DR ProteinModelPortal; Q9BZM6; -. DR SMR; Q9BZM6; -. DR BioGrid; 123241; 8. DR CORUM; Q9BZM6; -. DR IntAct; Q9BZM6; 1. DR STRING; 9606.ENSP00000229708; -. DR BioMuta; ULBP1; -. DR PaxDb; Q9BZM6; -. DR PeptideAtlas; Q9BZM6; -. DR PRIDE; Q9BZM6; -. DR ProteomicsDB; 79879; -. DR Ensembl; ENST00000229708; ENSP00000229708; ENSG00000111981. DR GeneID; 80329; -. DR KEGG; hsa:80329; -. DR UCSC; uc003qnp.5; human. DR CTD; 80329; -. DR DisGeNET; 80329; -. DR EuPathDB; HostDB:ENSG00000111981.4; -. DR GeneCards; ULBP1; -. DR HGNC; HGNC:14893; ULBP1. DR HPA; HPA007547; -. DR HPA; HPA071005; -. DR MIM; 605697; gene. DR neXtProt; NX_Q9BZM6; -. DR OpenTargets; ENSG00000111981; -. DR PharmGKB; PA37915; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR HOGENOM; HOG000070028; -. DR HOVERGEN; HBG052564; -. DR InParanoid; Q9BZM6; -. DR KO; K07986; -. DR OMA; CKMWLEE; -. DR OrthoDB; EOG091G0I62; -. DR PhylomeDB; Q9BZM6; -. DR TreeFam; TF341724; -. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR GeneWiki; ULBP1; -. DR GenomeRNAi; 80329; -. DR PRO; PR:Q9BZM6; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000111981; Expressed in 58 organ(s), highest expression level in cerebellar hemisphere. DR CleanEx; HS_ULBP1; -. DR Genevisible; Q9BZM6; HS. DR GO; GO:0015629; C:actin cytoskeleton; IDA:HPA. DR GO; GO:0046658; C:anchored component of plasma membrane; IDA:UniProtKB. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IDA:HPA. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IDA:UniProtKB. DR GO; GO:0030101; P:natural killer cell activation; IDA:UniProtKB. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0016032; P:viral process; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Cell membrane; Complete proteome; Disulfide bond; KW Endoplasmic reticulum; Glycoprotein; GPI-anchor; KW Host-virus interaction; Immunity; Lipoprotein; Membrane; Polymorphism; KW Reference proteome; Signal. FT SIGNAL 1 25 {ECO:0000250}. FT CHAIN 26 216 UL16-binding protein 1. FT /FTId=PRO_0000019015. FT PROPEP 217 244 Removed in mature form. {ECO:0000255}. FT /FTId=PRO_0000019016. FT REGION 26 117 MHC class I alpha-1 like. FT REGION 118 208 MHC class I alpha-2 like. FT LIPID 216 216 GPI-anchor amidated glycine. FT {ECO:0000255}. FT CARBOHYD 82 82 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 50 66 {ECO:0000250}. FT DISULFID 127 190 {ECO:0000250}. FT VARIANT 101 101 L -> I (in dbSNP:rs6903584). FT /FTId=VAR_050407. SQ SEQUENCE 244 AA; 27997 MW; 6094B17CE383DC6D CRC64; MAAAASPAFL LCLPLLHLLS GWSRAGWVDT HCLCYDFIIT PKSRPEPQWC EVQGLVDERP FLHYDCVNHK AKAFASLGKK VNVTKTWEEQ TETLRDVVDF LKGQLLDIQV ENLIPIEPLT LQARMSCEHE AHGHGRGSWQ FLFNGQKFLL FDSNNRKWTA LHPGAKKMTE KWEKNRDVTM FFQKISLGDC KMWLEEFLMY WEQMLDPTKP PSLAPGTTQP KAMATTLSPW SLLIIFLCFI LAGR // ID ULBP2_HUMAN Reviewed; 246 AA. AC Q9BZM5; Q5VUN4; DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 12-SEP-2018, entry version 140. DE RecName: Full=UL16-binding protein 2; DE AltName: Full=ALCAN-alpha; DE AltName: Full=NKG2D ligand 2; DE Short=N2DL-2; DE Short=NKG2DL2; DE AltName: Full=Retinoic acid early transcript 1H; DE Flags: Precursor; GN Name=ULBP2; Synonyms=N2DL2, RAET1H; ORFNames=UNQ463/PRO791; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND GPI-ANCHOR AT SER-216. RX PubMed=11239445; DOI=10.1016/S1074-7613(01)00095-4; RA Cosman D., Mullberg J., Sutherland C.L., Chin W., Armitage R., RA Fanslow W., Kubin M., Chalupny N.J.; RT "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein RT UL16 and stimulate NK cytotoxicity through the NKG2D receptor."; RL Immunity 14:123-133(2001). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, GPI-ANCHOR RP AT SER-216, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MUTAGENESIS RP OF 208-SER--GLY-210 AND 216-SER--GLY-218. RC TISSUE=Endometrial tumor; RX PubMed=11444831; DOI=10.1006/bbrc.2001.5149; RA Onda H., Ohkubo S., Shintani Y., Ogi K., Kikuchi K., Tanaka H., RA Yamamoto K., Tsuji I., Ishibashi Y., Yamada T., Kitada C., Suzuki N., RA Sawada H., Nishimura O., Fujino M.; RT "A novel secreted tumor antigen with a glycosylphosphatidylinositol- RT anchored structure ubiquitously expressed in human cancers."; RL Biochem. Biophys. Res. Commun. 285:235-243(2001). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=11827464; DOI=10.1006/geno.2001.6673; RA Radosavljevic M., Cuillerier B., Wilson M.J., Clement O., Wicker S., RA Gilfillan S., Beck S., Trowsdale J., Bahram S.; RT "A cluster of ten novel MHC class I related genes on human chromosome RT 6q24.2-q25.3."; RL Genomics 79:114-123(2002). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP FUNCTION, AND INTERACTION WITH KLRK1. RX PubMed=11777960; DOI=10.4049/jimmunol.168.2.671; RA Sutherland C.L., Chalupny N.J., Schooley K., VandenBos T., Kubin M., RA Cosman D.; RT "UL16-binding proteins, novel MHC class I-related proteins, bind to RT NKG2D and activate multiple signaling pathways in primary NK cells."; RL J. Immunol. 168:671-679(2002). RN [9] RP INTERACTION WITH CMV UL16, AND SUBCELLULAR LOCATION. RX PubMed=12782710; DOI=10.1084/jem.20022059; RA Dunn C., Chalupny N.J., Sutherland C.L., Dosch S., Sivakumar P.V., RA Johnson D.C., Cosman D.; RT "Human cytomegalovirus glycoprotein UL16 causes intracellular RT sequestration of NKG2D ligands, protecting against natural killer cell RT cytotoxicity."; RL J. Exp. Med. 197:1427-1439(2003). RN [10] RP REVIEW. RX PubMed=12753652; DOI=10.1034/j.1399-0039.2003.00070.x; RA Cerwenka A., Lanier L.L.; RT "NKG2D ligands: unconventional MHC class I-like molecules exploited by RT viruses and cancer."; RL Tissue Antigens 61:335-343(2003). CC -!- FUNCTION: Binds and activates the KLRK1/NKG2D receptor, mediating CC natural killer cell cytotoxicity. {ECO:0000269|PubMed:11777960}. CC -!- SUBUNIT: Interacts with KLRK1/NKG2D (PubMed:11777960). Does not CC bind to beta2-microglobulin (PubMed:12782710). CC {ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:12782710}. CC -!- SUBUNIT: (Microbial infection) In CMV-infected cells, interacts CC with the viral glycoprotein UL16; this interaction causes ULBP2 CC retention in the endoplasmic reticulum and cis-Golgi and prevents CC binding to and activation of KLRK1/NKG2D, providing CMV with an CC immune evasion mechanism. {ECO:0000269|PubMed:12782710}. CC -!- INTERACTION: CC P26718:KLRK1; NbExp=6; IntAct=EBI-3919993, EBI-458344; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12782710}; CC Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12782710}. CC Endoplasmic reticulum {ECO:0000269|PubMed:12782710}. Secreted CC {ECO:0000269|PubMed:11444831}. Note=In CMV-infected fibroblasts, CC detected in the endoplasmic reticulum/cis-Golgi. CC {ECO:0000269|PubMed:12782710}. CC -!- TISSUE SPECIFICITY: Expressed in various types of cancer cell CC lines and in the fetus, but not in normal tissues. CC {ECO:0000269|PubMed:11444831}. CC -!- MISCELLANEOUS: UL16-binding proteins (ULBPs) are unusual members CC of the extended MHC class I superfamily. They do not contain the CC alpha 3 domain and lack a transmembrane domain. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AF304378; AAK13082.1; -; mRNA. DR EMBL; AB052906; BAB61048.1; -; mRNA. DR EMBL; AY026825; AAK07688.1; -; mRNA. DR EMBL; AY358665; AAQ89028.1; -; mRNA. DR EMBL; AL583835; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471051; EAW47777.1; -; Genomic_DNA. DR EMBL; BC034689; AAH34689.1; -; mRNA. DR CCDS; CCDS5222.1; -. DR RefSeq; NP_079493.1; NM_025217.3. DR UniGene; Hs.656778; -. DR ProteinModelPortal; Q9BZM5; -. DR SMR; Q9BZM5; -. DR BioGrid; 123240; 17. DR CORUM; Q9BZM5; -. DR IntAct; Q9BZM5; 6. DR STRING; 9606.ENSP00000356320; -. DR iPTMnet; Q9BZM5; -. DR PhosphoSitePlus; Q9BZM5; -. DR BioMuta; ULBP2; -. DR EPD; Q9BZM5; -. DR MaxQB; Q9BZM5; -. DR PaxDb; Q9BZM5; -. DR PeptideAtlas; Q9BZM5; -. DR PRIDE; Q9BZM5; -. DR ProteomicsDB; 79878; -. DR Ensembl; ENST00000367351; ENSP00000356320; ENSG00000131015. DR GeneID; 80328; -. DR KEGG; hsa:80328; -. DR UCSC; uc003qno.4; human. DR CTD; 80328; -. DR DisGeNET; 80328; -. DR EuPathDB; HostDB:ENSG00000131015.4; -. DR GeneCards; ULBP2; -. DR HGNC; HGNC:14894; ULBP2. DR HPA; CAB018974; -. DR MIM; 605698; gene. DR neXtProt; NX_Q9BZM5; -. DR OpenTargets; ENSG00000131015; -. DR PharmGKB; PA37916; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR HOGENOM; HOG000070028; -. DR HOVERGEN; HBG052564; -. DR InParanoid; Q9BZM5; -. DR KO; K07986; -. DR OMA; NISMGDC; -. DR OrthoDB; EOG091G0I62; -. DR PhylomeDB; Q9BZM5; -. DR TreeFam; TF341724; -. DR Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins. DR SIGNOR; Q9BZM5; -. DR GeneWiki; ULBP2; -. DR GenomeRNAi; 80328; -. DR PRO; PR:Q9BZM5; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000131015; Expressed in 126 organ(s), highest expression level in oral cavity. DR CleanEx; HS_ULBP2; -. DR Genevisible; Q9BZM5; HS. DR GO; GO:0046658; C:anchored component of plasma membrane; IDA:UniProtKB. DR GO; GO:0009986; C:cell surface; IDA:BHF-UCL. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0005615; C:extracellular space; IDA:BHF-UCL. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IDA:UniProtKB. DR GO; GO:0030101; P:natural killer cell activation; IDA:UniProtKB. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0016032; P:viral process; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Cell membrane; Complete proteome; Direct protein sequencing; KW Disulfide bond; Endoplasmic reticulum; Glycoprotein; GPI-anchor; KW Host-virus interaction; Immunity; Lipoprotein; Membrane; KW Reference proteome; Secreted; Signal. FT SIGNAL 1 25 {ECO:0000269|PubMed:11444831}. FT CHAIN 26 216 UL16-binding protein 2. FT /FTId=PRO_0000019017. FT PROPEP 217 246 Removed in mature form. FT {ECO:0000305|PubMed:11444831}. FT /FTId=PRO_0000019018. FT REGION 29 117 MHC class I alpha-1 like. FT REGION 118 210 MHC class I alpha-2 like. FT LIPID 216 216 GPI-anchor amidated serine. FT {ECO:0000305|PubMed:11239445, FT ECO:0000305|PubMed:11444831}. FT CARBOHYD 68 68 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 82 82 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 50 66 {ECO:0000250}. FT DISULFID 127 190 {ECO:0000250}. FT MUTAGEN 208 210 SAG->TPV: Secreted. FT {ECO:0000269|PubMed:11444831}. FT MUTAGEN 216 218 SSG->TPV: Not secreted. FT {ECO:0000269|PubMed:11444831}. SQ SEQUENCE 246 AA; 27368 MW; 804D1A0D4A9C5CF8 CRC64; MAAAAATKIL LCLPLLLLLS GWSRAGRADP HSLCYDITVI PKFRPGPRWC AVQGQVDEKT FLHYDCGNKT VTPVSPLGKK LNVTTAWKAQ NPVLREVVDI LTEQLRDIQL ENYTPKEPLT LQARMSCEQK AEGHSSGSWQ FSFDGQIFLL FDSEKRMWTT VHPGARKMKE KWENDKVVAM SFHYFSMGDC IGWLEDFLMG MDSTLEPSAG APLAMSSGTT QLRATATTLI LCCLLIILPC FILPGI // ID ULBP3_HUMAN Reviewed; 244 AA. AC Q9BZM4; Q5VY82; Q8IZX5; Q8TE75; DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 12-SEP-2018, entry version 138. DE RecName: Full=UL16-binding protein 3; DE AltName: Full=ALCAN-gamma; DE AltName: Full=NKG2D ligand 3; DE Short=N2DL-3; DE Short=NKG2DL3; DE AltName: Full=Retinoic acid early transcript 1N; DE Flags: Precursor; GN Name=ULBP3; Synonyms=N2DL3, RAET1N; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND GPI-ANCHOR. RX PubMed=11239445; DOI=10.1016/S1074-7613(01)00095-4; RA Cosman D., Mullberg J., Sutherland C.L., Chin W., Armitage R., RA Fanslow W., Kubin M., Chalupny N.J.; RT "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein RT UL16 and stimulate NK cytotoxicity through the NKG2D receptor."; RL Immunity 14:123-133(2001). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Onda H., Shintani Y., Ohkubo S., Ogi K.; RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP NUCLEOTIDE SEQUENCE [MRNA] OF 9-244, AND INTERACTION WITH KLRK1. RX PubMed=11491531; DOI=10.1007/s002510100325; RA Steinle A., Li P., Morris D.L., Groh V., Lanier L.L., Strong R.K., RA Spies T.; RT "Interactions of human NKG2D with its ligands MICA, MICB, and homologs RT of the mouse RAE-1 protein family."; RL Immunogenetics 53:279-287(2001). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] OF 11-244. RX PubMed=11827464; DOI=10.1006/geno.2001.6673; RA Radosavljevic M., Cuillerier B., Wilson M.J., Clement O., Wicker S., RA Gilfillan S., Beck S., Trowsdale J., Bahram S.; RT "A cluster of ten novel MHC class I related genes on human chromosome RT 6q24.2-q25.3."; RL Genomics 79:114-123(2002). RN [9] RP FUNCTION, AND INTERACTION WITH KLRK1. RX PubMed=11777960; DOI=10.4049/jimmunol.168.2.671; RA Sutherland C.L., Chalupny N.J., Schooley K., VandenBos T., Kubin M., RA Cosman D.; RT "UL16-binding proteins, novel MHC class I-related proteins, bind to RT NKG2D and activate multiple signaling pathways in primary NK cells."; RL J. Immunol. 168:671-679(2002). RN [10] RP REVIEW. RX PubMed=12753652; DOI=10.1034/j.1399-0039.2003.00070.x; RA Cerwenka A., Lanier L.L.; RT "NKG2D ligands: unconventional MHC class I-like molecules exploited by RT viruses and cancer."; RL Tissue Antigens 61:335-343(2003). RN [11] RP INTERACTION WITH CMV UL142. RX PubMed=20530255; DOI=10.4049/jimmunol.1000789; RA Bennett N.J., Ashiru O., Morgan F.J., Pang Y., Okecha G., Eagle R.A., RA Trowsdale J., Sissons J.G., Wills M.R.; RT "Intracellular sequestration of the NKG2D ligand ULBP3 by human RT cytomegalovirus."; RL J. Immunol. 185:1093-1102(2010). RN [12] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [13] RP X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 30-207 IN COMPLEX WITH THE RP EXTRACELLULAR DOMAIN OF KLRK1. RX PubMed=11754823; DOI=10.1016/S1074-7613(01)00241-2; RA Radaev S., Rostro B., Brooks A.G., Colonna M., Sun P.D.; RT "Conformational plasticity revealed by the cocrystal structure of RT NKG2D and its class I MHC-like ligand ULBP3."; RL Immunity 15:1039-1049(2001). CC -!- FUNCTION: Binds and activates the KLRK1/NKG2D receptor, mediating CC natural killer cell cytotoxicity. {ECO:0000269|PubMed:11491531, CC ECO:0000269|PubMed:11754823, ECO:0000269|PubMed:11777960}. CC -!- SUBUNIT: Interacts with KLRK1/NKG2D (PubMed:11491531, CC PubMed:11777960, PubMed:11754823). Does not bind to beta2- CC microglobulin (By similarity). {ECO:0000250|UniProtKB:Q9BZM6, CC ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11754823, CC ECO:0000269|PubMed:11777960}. CC -!- SUBUNIT: (Microbial infection) In CMV-infected cells, interacts CC with the viral glycoprotein UL16 and UL142; this interaction CC causes ULBP3 retention in the endoplasmic reticulum and cis-Golgi CC and prevents binding to and activation of KLRK1/NKG2D, providing CC CMV with an immune evasion mechanism. CC {ECO:0000269|PubMed:20530255}. CC -!- INTERACTION: CC P26718:KLRK1; NbExp=4; IntAct=EBI-1032551, EBI-458344; CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000250|UniProtKB:Q9BZM6}; Lipid-anchor, GPI-anchor CC {ECO:0000250|UniProtKB:Q9BZM6}. CC -!- MISCELLANEOUS: UL16-binding proteins (ULBPs) are unusual members CC of the extended MHC class I superfamily. They do not contain the CC alpha 3 domain and lack a transmembrane domain. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AF304379; AAK13083.1; -; mRNA. DR EMBL; AB052908; BAB61050.1; -; mRNA. DR EMBL; AK315275; BAG37687.1; -; mRNA. DR EMBL; AL355497; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471051; EAW47772.1; -; Genomic_DNA. DR EMBL; BC098127; AAH98127.1; -; mRNA. DR EMBL; AF346596; AAN40839.1; -; mRNA. DR EMBL; AY027538; AAK13049.1; -; mRNA. DR CCDS; CCDS5225.1; -. DR RefSeq; NP_078794.1; NM_024518.2. DR UniGene; Hs.15422; -. DR UniGene; Hs.326556; -. DR PDB; 1KCG; X-ray; 2.60 A; C=30-207. DR PDBsum; 1KCG; -. DR ProteinModelPortal; Q9BZM4; -. DR SMR; Q9BZM4; -. DR BioGrid; 122673; 22. DR CORUM; Q9BZM4; -. DR IntAct; Q9BZM4; 1. DR STRING; 9606.ENSP00000356308; -. DR iPTMnet; Q9BZM4; -. DR PhosphoSitePlus; Q9BZM4; -. DR BioMuta; ULBP3; -. DR MaxQB; Q9BZM4; -. DR PaxDb; Q9BZM4; -. DR PeptideAtlas; Q9BZM4; -. DR PRIDE; Q9BZM4; -. DR ProteomicsDB; 79877; -. DR Ensembl; ENST00000367339; ENSP00000356308; ENSG00000131019. DR Ensembl; ENST00000438272; ENSP00000403562; ENSG00000131019. DR GeneID; 79465; -. DR KEGG; hsa:79465; -. DR UCSC; uc003qns.4; human. DR CTD; 79465; -. DR DisGeNET; 79465; -. DR EuPathDB; HostDB:ENSG00000131019.10; -. DR GeneCards; ULBP3; -. DR HGNC; HGNC:14895; ULBP3. DR HPA; HPA056541; -. DR HPA; HPA063007; -. DR MIM; 605699; gene. DR neXtProt; NX_Q9BZM4; -. DR OpenTargets; ENSG00000131019; -. DR PharmGKB; PA37917; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR HOGENOM; HOG000070028; -. DR HOVERGEN; HBG052564; -. DR InParanoid; Q9BZM4; -. DR KO; K07986; -. DR OMA; WGKQLEM; -. DR OrthoDB; EOG091G0I62; -. DR PhylomeDB; Q9BZM4; -. DR TreeFam; TF341724; -. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR EvolutionaryTrace; Q9BZM4; -. DR GeneWiki; ULBP3; -. DR GenomeRNAi; 79465; -. DR PRO; PR:Q9BZM4; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000131019; Expressed in 86 organ(s), highest expression level in testis. DR CleanEx; HS_ULBP3; -. DR Genevisible; Q9BZM4; HS. DR GO; GO:0046658; C:anchored component of plasma membrane; IDA:UniProtKB. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IDA:UniProtKB. DR GO; GO:0030101; P:natural killer cell activation; IDA:UniProtKB. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0016032; P:viral process; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW 3D-structure; Cell membrane; Complete proteome; Disulfide bond; KW Glycoprotein; GPI-anchor; Host-virus interaction; Immunity; KW Lipoprotein; Membrane; Reference proteome; Signal. FT SIGNAL 1 29 {ECO:0000255}. FT CHAIN 30 217 UL16-binding protein 3. FT /FTId=PRO_0000019019. FT PROPEP 218 244 Removed in mature form. {ECO:0000255}. FT /FTId=PRO_0000019020. FT REGION 30 118 MHC class I alpha-1 like. FT REGION 119 209 MHC class I alpha-2 like. FT LIPID 217 217 GPI-anchor amidated glycine. FT {ECO:0000255}. FT CARBOHYD 37 37 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 51 67 FT DISULFID 128 191 FT STRAND 32 43 {ECO:0000244|PDB:1KCG}. FT STRAND 50 57 {ECO:0000244|PDB:1KCG}. FT STRAND 60 66 {ECO:0000244|PDB:1KCG}. FT TURN 67 70 {ECO:0000244|PDB:1KCG}. FT STRAND 83 85 {ECO:0000244|PDB:1KCG}. FT HELIX 86 107 {ECO:0000244|PDB:1KCG}. FT STRAND 121 130 {ECO:0000244|PDB:1KCG}. FT STRAND 137 153 {ECO:0000244|PDB:1KCG}. FT TURN 154 157 {ECO:0000244|PDB:1KCG}. FT STRAND 158 163 {ECO:0000244|PDB:1KCG}. FT HELIX 164 166 {ECO:0000244|PDB:1KCG}. FT HELIX 167 175 {ECO:0000244|PDB:1KCG}. FT HELIX 177 188 {ECO:0000244|PDB:1KCG}. FT HELIX 190 206 {ECO:0000244|PDB:1KCG}. SQ SEQUENCE 244 AA; 27949 MW; BAF07895640B9901 CRC64; MAAAASPAIL PRLAILPYLL FDWSGTGRAD AHSLWYNFTI IHLPRHGQQW CEVQSQVDQK NFLSYDCGSD KVLSMGHLEE QLYATDAWGK QLEMLREVGQ RLRLELADTE LEDFTPSGPL TLQVRMSCEC EADGYIRGSW QFSFDGRKFL LFDSNNRKWT VVHAGARRMK EKWEKDSGLT TFFKMVSMRD CKSWLRDFLM HRKKRLEPTA PPTMAPGLAQ PKAIATTLSP WSFLIILCFI LPGI // ID RAE1E_HUMAN Reviewed; 263 AA. AC Q8TD07; A6YF59; Q5VYB7; Q5VYB8; Q8TEZ2; Q96L41; DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 12-SEP-2018, entry version 141. DE RecName: Full=Retinoic acid early transcript 1E {ECO:0000303|PubMed:11827464, ECO:0000312|HGNC:HGNC:16793}; DE AltName: Full=Lymphocyte effector toxicity activation ligand {ECO:0000303|PubMed:14508119}; DE AltName: Full=NKG2D ligand 4; DE Short=N2DL-4; DE Short=NKG2DL4; DE AltName: Full=RAE-1-like transcript 4 {ECO:0000303|Ref.5}; DE AltName: Full=UL16-binding protein 4; DE Flags: Precursor; GN Name=RAET1E {ECO:0000303|PubMed:11827464, GN ECO:0000312|HGNC:HGNC:16793}; GN Synonyms=LETAL {ECO:0000303|PubMed:14508119}, N2DL4, GN ULBP4 {ECO:0000303|PubMed:12732206}; GN ORFNames=UNQ1867/PRO4303 {ECO:0000303|PubMed:12975309}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY. RC TISSUE=Ovarian carcinoma; RX PubMed=14508119; DOI=10.4161/cbt.2.4.479; RA Conejo-Garcia J.-R., Benencia F., Courreges M.C., Khang E., Zhang L., RA Mohamed-Hadley A., Vinocur J.M., Buckanovich R.J., Thompson C.B., RA Levine B., Coukos G.; RT "Letal, a tumor-associated NKG2D immunoreceptor ligand, induces RT activation and expansion of effector immune cells."; RL Cancer Biol. Ther. 2:446-451(2003). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY. RC TISSUE=Esophagus; RX PubMed=12732206; DOI=10.1016/S0006-291X(03)00714-9; RA Chalupny N.J., Sutherland C.L., Lawrence W.A., Rein-Weston A., RA Cosman D.; RT "ULBP4 is a novel ligand for human NKG2D."; RL Biochem. Biophys. Res. Commun. 305:129-135(2003). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH KLRK1, LACK RP OF INTERACTION WITH CMV UL16, AND SUBCELLULAR LOCATION. RX PubMed=15240696; DOI=10.4049/jimmunol.173.2.1078; RA Bacon L., Eagle R.A., Meyer M., Easom N., Young N.T., Trowsdale J.; RT "Two human ULBP/RAET1 molecules with transmembrane regions are ligands RT for NKG2D."; RL J. Immunol. 173:1078-1084(2004). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), AND ALTERNATIVE SPLICING. RX PubMed=17470428; DOI=10.1074/jbc.M702504200; RA Cao W., Xi X., Hao Z., Li W., Kong Y., Cui L., Ma C., Ba D., He W.; RT "RAET1E2, a soluble isoform of the UL16-binding protein RAET1E RT produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity."; RL J. Biol. Chem. 282:18922-18928(2007). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). RA Lanier L.L., Cerwenka A.; RT "Homo sapiens RAE-1-like transcript 4 (RL-4) mRNA."; RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT RP ASN-82. RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-222 (ISOFORM 1), AND VARIANTS ASN-82 RP AND HIS-128. RX PubMed=11827464; DOI=10.1006/geno.2001.6673; RA Radosavljevic M., Cuillerier B., Wilson M.J., Clement O., Wicker S., RA Gilfillan S., Beck S., Trowsdale J., Bahram S.; RT "A cluster of ten novel MHC class I related genes on human chromosome RT 6q24.2-q25.3."; RL Genomics 79:114-123(2002). RN [9] RP ALTERNATIVE SPLICING (ISOFORMS 2; 5 AND 6), INTERACTION WITH KLRK1, RP FUNCTION, REGION, AND DOMAIN. RX PubMed=18544572; DOI=10.1093/intimm/dxn057; RA Cao W., Xi X., Wang Z., Dong L., Hao Z., Cui L., Ma C., He W.; RT "Four novel ULBP splice variants are ligands for human NKG2D."; RL Int. Immunol. 20:981-991(2008). CC -!- FUNCTION: Binds and activates the KLRK1/NKG2D receptor, mediating CC natural killer cell cytotoxicity. {ECO:0000269|PubMed:15240696, CC ECO:0000269|PubMed:18544572}. CC -!- SUBUNIT: Binds to KLRK1/NKG2D. {ECO:0000269|PubMed:15240696, CC ECO:0000269|PubMed:18544572}. CC -!- SUBUNIT: (Microbial infection) Contrary to other family members, CC does not interact with CMV glycoprotein UL16. CC {ECO:0000269|PubMed:15240696}. CC -!- INTERACTION: CC P26718:KLRK1; NbExp=4; IntAct=EBI-16365677, EBI-458344; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:15240696}; CC Single-pass type I membrane protein. CC -!- SUBCELLULAR LOCATION: Isoform 4: Secreted. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=6; CC Name=1; Synonyms=ULBP4 {ECO:0000303|PubMed:12732206}, RAET1E CC {ECO:0000303|PubMed:15240696}; CC IsoId=Q8TD07-1; Sequence=Displayed; CC Name=2; Synonyms=RL-4 {ECO:0000303|Ref.5}, ULBP4-II CC {ECO:0000303|PubMed:18544572}; CC IsoId=Q8TD07-2; Sequence=VSP_010441; CC Name=3; CC IsoId=Q8TD07-3; Sequence=VSP_010442, VSP_010443; CC Note=No experimental confirmation available.; CC Name=4; Synonyms=RAET1E2 {ECO:0000303|PubMed:17470428}; CC IsoId=Q8TD07-4; Sequence=VSP_045012; CC Name=5; Synonyms=ULBP4-III {ECO:0000303|PubMed:18544572}; CC IsoId=Q8TD07-5; Sequence=VSP_059263; CC Name=6; Synonyms=ULBP4-I {ECO:0000303|PubMed:18544572}; CC IsoId=Q8TD07-6; Sequence=VSP_059262; CC -!- TISSUE SPECIFICITY: Predominantly expressed in the skin, but also CC expressed in testis and trachea. Up-regulated in tumor cells of CC different origins. Expression progressively decreased after CC treatment of tumor cells with retinoic acid. CC {ECO:0000269|PubMed:12732206, ECO:0000269|PubMed:14508119}. CC -!- DOMAIN: MHC class I alpha-1 like and MHC class I alpha- like CC regions down-regulate the cell surface expression of KLRK1. CC {ECO:0000269|PubMed:18544572}. CC -!- MISCELLANEOUS: UL16-binding proteins (ULBPs) are unusual members CC of the extended MHC class I superfamily. They do not contain the CC alpha 3 domain and lack a transmembrane domain. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC -!- CAUTION: Contrary to other family members, does not interact with CC CMV glycoprotein UL16. {ECO:0000269|PubMed:15240696}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AY069961; AAL58090.1; -; mRNA. DR EMBL; AY252119; AAP15166.1; -; mRNA. DR EMBL; AY176317; AAO22240.1; -; mRNA. DR EMBL; EF489426; ABR29881.1; -; mRNA. DR EMBL; AY054974; AAL11005.1; -; mRNA. DR EMBL; AY359075; AAQ89434.1; -; mRNA. DR EMBL; AL355312; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AF359243; AAL76417.1; -; mRNA. DR CCDS; CCDS5221.1; -. [Q8TD07-1] DR CCDS; CCDS59042.1; -. [Q8TD07-4] DR CCDS; CCDS59043.1; -. [Q8TD07-3] DR CCDS; CCDS59044.1; -. [Q8TD07-2] DR RefSeq; NP_001230254.1; NM_001243325.1. [Q8TD07-2] DR RefSeq; NP_001230256.1; NM_001243327.1. [Q8TD07-4] DR RefSeq; NP_001230257.1; NM_001243328.1. [Q8TD07-3] DR RefSeq; NP_631904.1; NM_139165.2. [Q8TD07-1] DR RefSeq; XP_011533781.1; XM_011535479.2. [Q8TD07-3] DR UniGene; Hs.511818; -. DR ProteinModelPortal; Q8TD07; -. DR SMR; Q8TD07; -. DR BioGrid; 126425; 19. DR IntAct; Q8TD07; 1. DR STRING; 9606.ENSP00000349709; -. DR PhosphoSitePlus; Q8TD07; -. DR BioMuta; RAET1E; -. DR PaxDb; Q8TD07; -. DR PeptideAtlas; Q8TD07; -. DR PRIDE; Q8TD07; -. DR ProteomicsDB; 74206; -. DR ProteomicsDB; 74207; -. [Q8TD07-2] DR ProteomicsDB; 74208; -. [Q8TD07-3] DR Ensembl; ENST00000357183; ENSP00000349709; ENSG00000164520. [Q8TD07-1] DR Ensembl; ENST00000367363; ENSP00000356332; ENSG00000164520. [Q8TD07-2] DR Ensembl; ENST00000529948; ENSP00000432366; ENSG00000164520. [Q8TD07-4] DR Ensembl; ENST00000532335; ENSP00000437067; ENSG00000164520. [Q8TD07-3] DR GeneID; 135250; -. DR KEGG; hsa:135250; -. DR UCSC; uc003qnj.3; human. [Q8TD07-1] DR CTD; 135250; -. DR DisGeNET; 135250; -. DR EuPathDB; HostDB:ENSG00000164520.11; -. DR GeneCards; RAET1E; -. DR H-InvDB; HIX0032797; -. DR HGNC; HGNC:16793; RAET1E. DR HPA; HPA054022; -. DR MIM; 609243; gene. DR neXtProt; NX_Q8TD07; -. DR OpenTargets; ENSG00000164520; -. DR PharmGKB; PA134913788; -. DR eggNOG; ENOG410JBPA; Eukaryota. DR eggNOG; ENOG411150N; LUCA. DR GeneTree; ENSGT00390000003472; -. DR HOGENOM; HOG000070028; -. DR HOVERGEN; HBG052564; -. DR InParanoid; Q8TD07; -. DR KO; K07987; -. DR OMA; WQFAING; -. DR OrthoDB; EOG091G0NI5; -. DR PhylomeDB; Q8TD07; -. DR TreeFam; TF339658; -. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR GeneWiki; RAET1E; -. DR GenomeRNAi; 135250; -. DR PRO; PR:Q8TD07; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000164520; Expressed in 90 organ(s), highest expression level in ectocervix. DR CleanEx; HS_RAET1E; -. DR ExpressionAtlas; Q8TD07; baseline and differential. DR Genevisible; Q8TD07; HS. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IPI:UniProtKB. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; KW Immunity; Membrane; Polymorphism; Reference proteome; Secreted; KW Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 30 {ECO:0000255}. FT CHAIN 31 263 Retinoic acid early transcript 1E. FT /FTId=PRO_0000019021. FT TOPO_DOM 31 225 Extracellular. {ECO:0000255}. FT TRANSMEM 226 248 Helical. {ECO:0000255}. FT TOPO_DOM 249 263 Cytoplasmic. {ECO:0000255}. FT REGION 31 116 MHC class I alpha-1 like; down-regulates FT the cell surface expression of KLRK1. FT {ECO:0000269|PubMed:18544572}. FT REGION 117 207 MHC class I alpha-2 like; down-regulates FT the cell surface expression of KLRK1. FT {ECO:0000269|PubMed:18544572}. FT COMPBIAS 219 222 Poly-Ser. FT CARBOHYD 36 36 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 154 154 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 212 212 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 126 189 {ECO:0000250}. FT VAR_SEQ 28 63 Missing (in isoform 2). FT {ECO:0000303|Ref.5}. FT /FTId=VSP_010441. FT VAR_SEQ 29 29 G -> GECPEHKNWLRTRRREKG (in isoform 6). FT {ECO:0000303|PubMed:18544572}. FT /FTId=VSP_059262. FT VAR_SEQ 165 208 SKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPE FT PTV -> M (in isoform 5). FT {ECO:0000303|PubMed:18544572}. FT /FTId=VSP_059263. FT VAR_SEQ 208 263 VSPVNASDIHWSSSSLPDRWIILGAFILLVLMGIVLICVWW FT QNGEWQAGLWPLRTS -> GN (in isoform 4). FT {ECO:0000303|PubMed:17470428}. FT /FTId=VSP_045012. FT VAR_SEQ 208 212 VSPVN -> GRRST (in isoform 3). FT {ECO:0000303|PubMed:12975309}. FT /FTId=VSP_010442. FT VAR_SEQ 213 263 Missing (in isoform 3). FT {ECO:0000303|PubMed:12975309}. FT /FTId=VSP_010443. FT VARIANT 12 12 R -> H (in dbSNP:rs9383583). FT /FTId=VAR_024534. FT VARIANT 82 82 Y -> N (in dbSNP:rs2151910). FT {ECO:0000269|PubMed:11827464, FT ECO:0000269|PubMed:12975309}. FT /FTId=VAR_020271. FT VARIANT 128 128 R -> H (in dbSNP:rs6925151). FT {ECO:0000269|PubMed:11827464}. FT /FTId=VAR_024535. FT VARIANT 141 141 A -> T (in dbSNP:rs9383921). FT /FTId=VAR_050408. FT VARIANT 142 142 T -> I (in dbSNP:rs9371533). FT /FTId=VAR_050409. FT VARIANT 194 194 R -> G (in dbSNP:rs57292884). FT /FTId=VAR_061483. FT VARIANT 237 237 V -> L (in dbSNP:rs2342767). FT /FTId=VAR_024536. FT CONFLICT 141 142 AT -> TI (in Ref. 8; AAL76417). FT {ECO:0000305}. SQ SEQUENCE 263 AA; 30122 MW; 3309279B51B603C8 CRC64; MRRISLTSSP VRLLLFLLLL LIALEIMVGG HSLCFNFTIK SLSRPGQPWC EAQVFLNKNL FLQYNSDNNM VKPLGLLGKK VYATSTWGEL TQTLGEVGRD LRMLLCDIKP QIKTSDPSTL QVEMFCQREA ERCTGASWQF ATNGEKSLLF DAMNMTWTVI NHEASKIKET WKKDRGLEKY FRKLSKGDCD HWLREFLGHW EAMPEPTVSP VNASDIHWSS SSLPDRWIIL GAFILLVLMG IVLICVWWQN GEWQAGLWPL RTS // ID O19441_MOUSE Unreviewed; 368 AA. AC O19441; DT 01-JAN-1998, integrated into UniProtKB/TrEMBL. DT 01-JAN-1998, sequence version 1. DT 12-SEP-2018, entry version 169. DE SubName: Full=Histocompatibility 2, Q region locus 1 {ECO:0000313|Ensembl:ENSMUSP00000072942}; DE SubName: Full=MCG68121, isoform CRA_b {ECO:0000313|EMBL:EDL06699.1}; DE SubName: Full=Major histocompability complex Q1b {ECO:0000313|EMBL:AAB71648.1}; GN Name=H2-Q1 {ECO:0000313|Ensembl:ENSMUSP00000072942, GN ECO:0000313|MGI:MGI:95928}; GN ORFNames=mCG_68121 {ECO:0000313|EMBL:EDL06699.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAB71648.1}; RN [1] {ECO:0000313|EMBL:AAB71648.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57Bl/6 {ECO:0000313|EMBL:AAB71648.1}; RA Dong L., Ma Q., Whitlock J.P.Jr.; RT "Down-regulation of major histocompatibility complex Q1b gene RT expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin."; RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:EDL06699.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL06699.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [3] {ECO:0000313|EMBL:EDL06699.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL06699.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSMUSP00000072942, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000072942, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [5] {ECO:0000313|Ensembl:ENSMUSP00000072942} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000072942}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR974466; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; U96752; AAB71648.1; -; mRNA. DR EMBL; CH466827; EDL06699.1; -; Genomic_DNA. DR PIR; PS0117; PS0117. DR RefSeq; NP_034520.2; NM_010390.3. DR UniGene; Mm.466882; -. DR STRING; 10090.ENSMUSP00000072942; -. DR Ensembl; ENSMUST00000073208; ENSMUSP00000072942; ENSMUSG00000079507. DR GeneID; 15006; -. DR UCSC; uc008chj.2; mouse. DR CTD; 15006; -. DR MGI; MGI:95928; H2-Q1. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR OMA; CEGETHP; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000079507; Expressed in 19 organ(s), highest expression level in colon. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; ISO:MGI. DR GO; GO:0042277; F:peptide binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0046977; F:TAP binding; ISO:MGI. DR GO; GO:0019882; P:antigen processing and presentation; IMP:MGI. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 368 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015096742. FT TRANSMEM 306 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 41322 MW; A930FF82832C8EE0 CRC64; MALGRLLLLL AAALTLTKTG AGSHSLRYFE TSVSRPGFGK PRFISVGYVD DTQFVRFDSD AKNPRYEPRA PWMEQEGPEY WERNTRRVKG SEKRFQESLS TLLSYYNQSK GGIHTFQKLS GCDLGSDGRL QSGYLQFAYD GLDYIALNED LETWTAADVA AQETRRKWEQ AGAAEKHRTY LEGKCLMWLH RYLELGKEML LRTDPPKAHV THHPRSQGDV TLRCWALGFY PADITLTWQL NGEELTQDME LVETRPAGDG TFQKWASVVV PLGKEQNYTC HVYHEGLPEP LTLRWEPPPY TVSNMVIIAV LVVLGAVIVI GAVVIIGVMV SFVMKRRRNK GGQGEDCALA PSRDSAQSSD ISLLDCKA // ID O19442_MOUSE Unreviewed; 342 AA. AC O19442; DT 01-JAN-1998, integrated into UniProtKB/TrEMBL. DT 01-JAN-1998, sequence version 1. DT 12-SEP-2018, entry version 162. DE SubName: Full=Histocompatibility 2, M region locus 9 {ECO:0000313|Ensembl:ENSMUSP00000084411}; DE SubName: Full=Histocompatibility 2, M region locus 9, isoform CRA_b {ECO:0000313|EMBL:EDL23298.1}; DE SubName: Full=MHC class Ib antigen {ECO:0000313|EMBL:AAC12894.1}; GN Name=H2-M9 {ECO:0000313|EMBL:EDL23298.1, GN ECO:0000313|Ensembl:ENSMUSP00000084411, ECO:0000313|MGI:MGI:1276570}; GN Synonyms=M9 {ECO:0000313|EMBL:AAO33435.1}; GN ORFNames=mCG_23228 {ECO:0000313|EMBL:EDL23298.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAC12894.1}; RN [1] {ECO:0000313|EMBL:AAC12894.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BALB/c {ECO:0000313|EMBL:AAC12894.1}; RC TISSUE=Liver {ECO:0000313|EMBL:AAC12894.1}; RX PubMed=9435345; DOI=10.1007/s002510050356; RA Arepalli S.R., Jones E.P., Howcroft T.K., Carlo I., Wang C., RA Lindahl K.F., Singer D.S., Rudikoff S.; RT "Characterization of two class I genes from the H2-M region: evidence RT for a new subfamily."; RL Immunogenetics 47:264-271(1998). RN [2] {ECO:0000313|EMBL:EDL23298.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL23298.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [3] {ECO:0000313|EMBL:AAO33435.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAO33435.1}; RA Chen M., Stroynowski I.; RT "Transcription of a mouse MHC class Ib gene, M9 in hepatocytes."; RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:EDL23298.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL23298.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|Ensembl:ENSMUSP00000084411, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000084411, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [6] {ECO:0000313|Ensembl:ENSMUSP00000084411} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000084411}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC126245; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AF016308; AAC12894.1; -; Genomic_DNA. DR EMBL; AF469488; AAO33435.1; -; mRNA. DR EMBL; CH466559; EDL23298.1; -; Genomic_DNA. DR RefSeq; NP_032231.1; NM_008205.1. DR UniGene; Mm.57004; -. DR STRING; 10090.ENSMUSP00000084411; -. DR DNASU; 14997; -. DR Ensembl; ENSMUST00000087167; ENSMUSP00000084411; ENSMUSG00000067201. DR GeneID; 14997; -. DR KEGG; mmu:14997; -. DR UCSC; uc008clc.1; mouse. DR CTD; 14997; -. DR MGI; MGI:1276570; H2-M9. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; RREPWYL; -. DR OrthoDB; EOG091G1MMC; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000067201; Expressed in 89 organ(s), highest expression level in mammary gland. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 342 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015096741. FT TRANSMEM 307 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 342 AA; 39881 MW; AB5B6EC1DB4D93BD CRC64; MKNFESQPLL LLFMVTLVIA KHPNGSHTLR FVSTFLSWPR HLELQFIFLI YVDETQIMGF NSISESQRME SRVPWLNELN AEFWELATQD VLKEKSFVTG IMNKLLHIYN DSMTGYHIIQ ETYGCQVKQR TYFSHAFMEL LFDTHDYITL NEDLQTWRAV GKAAEIVKEE WEKINLVKSS KSFLLGACVE GLLQYLNFGK KYLLRTDTPK IHMTYKIRPD RKITLRCWAF NFYPPEITLT WQRDGSNQTQ DMEVIEIRPS GDGTFQKWAA VVVSSGEEHR YTCHVNHEGL SEPVTLRWDP PEPTIPFLPM IIALVLGALL MGSVMTFLIW KRRTRGKKGS WS // ID O19443_MOUSE Unreviewed; 331 AA. AC O19443; DT 01-JAN-1998, integrated into UniProtKB/TrEMBL. DT 01-JAN-1998, sequence version 1. DT 12-SEP-2018, entry version 157. DE SubName: Full=Histocompatibility 2, M region locus 10.1 {ECO:0000313|EMBL:AAI19459.1, ECO:0000313|Ensembl:ENSMUSP00000025322}; DE SubName: Full=MHC class Ib antigen {ECO:0000313|EMBL:AAC12895.1}; GN Name=H2-M10.1 {ECO:0000313|EMBL:AAI19459.1, GN ECO:0000313|Ensembl:ENSMUSP00000025322, ECO:0000313|MGI:MGI:1276522}; GN Synonyms=M10 {ECO:0000313|EMBL:AAC12895.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAC12895.1}; RN [1] {ECO:0000313|EMBL:AAC12895.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BALB/c {ECO:0000313|EMBL:AAC12895.1}; RC TISSUE=Liver {ECO:0000313|EMBL:AAC12895.1}; RX PubMed=9435345; DOI=10.1007/s002510050356; RA Arepalli S.R., Jones E.P., Howcroft T.K., Carlo I., Wang C., RA Lindahl K.F., Singer D.S., Rudikoff S.; RT "Characterization of two class I genes from the H2-M region: evidence RT for a new subfamily."; RL Immunogenetics 47:264-271(1998). RN [2] {ECO:0000313|EMBL:AAO50320.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAO50320.1}; RC TISSUE=Vomeronasal organ {ECO:0000313|EMBL:AAO50320.1}; RX PubMed=12620187; DOI=10.1016/S0960-9822(03)00092-7; RA Ishii T., Hirota J., Mombaerts P.; RT "Combinatorial coexpression of neural and immune multigene families in RT mouse vomeronasal sensory neurons."; RL Curr. Biol. 13:394-400(2003). RN [3] {ECO:0000313|EMBL:AAI19459.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI19459.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000025322, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000025322, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [5] {ECO:0000313|Ensembl:ENSMUSP00000025322} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000025322}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC129554; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AF016309; AAC12895.1; -; Genomic_DNA. DR EMBL; BC119458; AAI19459.1; -; mRNA. DR EMBL; AF539597; AAO50320.1; -; mRNA. DR RefSeq; NP_038572.3; NM_013544.3. DR UniGene; Mm.347438; -. DR STRING; 10090.ENSMUSP00000025322; -. DR Ensembl; ENSMUST00000025322; ENSMUSP00000025322; ENSMUSG00000024448. DR GeneID; 14985; -. DR UCSC; uc008cky.1; mouse. DR CTD; 14985; -. DR MGI; MGI:1276522; H2-M10.1. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR OMA; WIELEPP; -. DR OrthoDB; EOG091G086C; -. DR TreeFam; TF336617; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000024448; Expressed in 25 organ(s), highest expression level in cardiac ventricle. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 331 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015096739. FT TRANSMEM 306 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 331 AA; 37666 MW; 46F65A6DB56269F2 CRC64; MRNTGPCTLL LLLMVALDLN HYCAGSHWLQ TFNIVILEPG MLEPRFIQVS YVDSIQYQGF DSKDPSAGMQ PRAAWIELEP PEYWEKETSR VLELSQVERQ VLRLMVKKNG HKMDGYHTLQ EVYGCNVAND GSFLGGHYRL TYYGYDYLTL NEDLSSWTAE GKGAQHAKSR WEDAGEAKRR KTYLQGECVQ RLLRYLDLGK ETLLCSDAPQ THVTHHVRPE GNVTLRCWAL GFYPADITMT WKRDGNNLTQ DMELPDTRPA GDGTFQKWAA VVVPSGEELR YTCHVHHEGL PEPLTLKWEP PHTIPIIAIL IGLVLGTLVV GTVVIFLVWR K // ID O19617_HUMAN Unreviewed; 366 AA. AC O19617; A0A090KMD8; DT 01-JAN-1998, integrated into UniProtKB/TrEMBL. DT 01-JAN-1998, sequence version 1. DT 12-SEP-2018, entry version 170. DE SubName: Full=HLA class I antigen {ECO:0000313|EMBL:BAA22206.1}; DE SubName: Full=HLA class I histocompatibility antigen, Cw-6 alpha chain {ECO:0000313|Ensembl:ENSP00000414063}; DE SubName: Full=HLA-C protein {ECO:0000313|EMBL:BAB63310.1}; DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:ACV91118.1}; DE SubName: Full=Major histocompatibility complex, class I, C {ECO:0000313|EMBL:AAH33293.1}; GN Name=HLA-C {ECO:0000313|EMBL:BAA22206.1, GN ECO:0000313|Ensembl:ENSP00000414063}; GN Synonyms=HLA-Cw {ECO:0000313|EMBL:ACV91118.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAA22206.1}; RN [1] {ECO:0000313|EMBL:BAA22206.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=9177776; DOI=10.1006/geno.1997.4708; RA Mizuki N., Ando H., Kimura M., Ohno S., Miyata S., Yamazaki M., RA Tashiro H., Watanabe K., Ono A., Taguchi S., Sugawara C., Fukuzumi Y., RA Okumura K., Goto K., Ishihara M., Nakamura S., Yonemoto J., RA Kikuti Y.Y., Shiina T., Chen L., Ando A., Ikemura T., Inoko H.; RT "Nucleotide sequence analysis of the HLA class I region spanning the RT 237-kb segment around the HLA-B and -C genes."; RL Genomics 42:55-66(1997). RN [2] {ECO:0000313|EMBL:BAB63310.1} RP NUCLEOTIDE SEQUENCE. RA Hirakawa M., Yamaguchi H., Imai K., Shimada J.; RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSP00000414063, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [4] {ECO:0000313|EMBL:AAH33293.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Skin {ECO:0000313|EMBL:AAH33293.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] {ECO:0000313|EMBL:BAB63310.1} RP NUCLEOTIDE SEQUENCE. RA Shiina S., Tamiya G., Oka A., Inoko H.; RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."; RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:ACV91118.1} RP NUCLEOTIDE SEQUENCE. RA Xu Y., Deng Z., Wang D.; RT "Characterization and polymorphism analyses of HLA-C genomic full RT length in Chinese Han population."; RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:CCP37718.1} RP NUCLEOTIDE SEQUENCE. RA Witter K.; RT "Confirmation of rare HLA class I alleles."; RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:BAN59792.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=23714642; DOI=10.1186/1471-2164-14-355; RA Hosomichi K., Jinam T.A., Mitsunaga S., Nakaoka H., Inoue I.; RT "Phase-defined complete sequencing of the HLA genes by next-generation RT sequencing."; RL BMC Genomics 14:355-355(2013). RN [9] {ECO:0000313|EMBL:CCG58319.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24033148; DOI=10.1111/tan.12192; RA Cisneros E., Martinez-Pomar N., Vilches M., Martin P., de Pablo R., RA Nunez Del Prado N., Nieto A., Matamoros N., Moraru M., Vilches C.; RT "Advancing allele group-specific amplification of the complete HLA-C RT gene--isolation of novel alleles from three allele groups (C*04, C*07 RT and C*08)."; RL Tissue Antigens 82:280-285(2013). RN [10] {ECO:0000313|EMBL:CDK41184.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Lymphoblastoid cell line {ECO:0000313|EMBL:CDK41184.1}; RA McWhinnie A.J., Robinson J.; RT "Confirmatory sequencing of HLA-C*07:01:01:01."; RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:CEH11580.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Peripheral blood {ECO:0000313|EMBL:CEH11580.1}; RA Du Toit E., Schlaphoff T., Borrill V., Brosnan N., Hayhurst J.D., RA Marsh S.G.E.; RT "Novel and confirmatory HLA class I alleles identified by third RT generation sequencing."; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|Ensembl:ENSP00000414063} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. RN [13] {ECO:0000313|EMBL:CUA55111.1} RP NUCLEOTIDE SEQUENCE. RA Noorani M.; RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:CUU97291.1} RP NUCLEOTIDE SEQUENCE. RA Albrecht V., Boehme I., Schmidt A.H.; RT "Characterisation and Confirmation of new HLA-Alleles found by DKMS RT Life Science Lab."; RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:ALZ40822.1} RP NUCLEOTIDE SEQUENCE. RA Bravo-Egana V., Clark P., Monos D.; RT "Generation of high confidence HLA genotyping and consensus sequences RT for Class I HLA loci using the NGS-based Omixon Holotype HLA typing RT system and the Illumina MiSeq platform."; RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:ANG08604.1} RP NUCLEOTIDE SEQUENCE. RA Barsakis K., Babrzadeh F., Chi A., Mindrinos M.N., RA Fernandez Vina M.A.; RT "HLA variation in coding and non-coding gene segments."; RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:SBL08196.1} RP NUCLEOTIDE SEQUENCE. RA Ploux O.; RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:SCQ83615.1} RP NUCLEOTIDE SEQUENCE. RA Schellekens J., Voorter C., Tilanus M.; RT "Two novel HLA-C alleles identified by sequencing-based typing: HLA- RT C*03:04:01:XX and HLA-C*07:01:01:XX."; RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:CUA55111.1} RP NUCLEOTIDE SEQUENCE. RA Marsh S.G.E.; RT "Full-length genomic HLA sequences."; RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|EMBL:SFV42124.1} RP NUCLEOTIDE SEQUENCE. RA Capua I., De Benedictis P., Joannis T., Lombin L.H., Cattoli G.; RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0000313|EMBL:CDQ51644.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28547825; DOI=.1111/tan.13057; RA Albrecht V., Zweiniger C., Surendranath V., Lang K., Schofl G., RA Dahl A., Winkler S., Lange V., Bohme I., Schmidt A.H.; RT "Dual redundant sequencing strategy: Full-length gene characterisation RT of 1056 novel and confirmatory HLA alleles."; RL HLA. 90:79-87(2017). RN [22] {ECO:0000313|EMBL:ASU50293.1} RP NUCLEOTIDE SEQUENCE. RA Balz V., Krause S., Enczmann J., Fischer J.; RT "More than 130 novel variants of HLA class 1 genes detected in German RT Stem Cell Donor Registry and Terasaki samples."; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [23] {ECO:0000313|EMBL:SBL08196.1} RP NUCLEOTIDE SEQUENCE. RA Marsh S.G.E.; RT "Full-length genomic HLA sequences."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [24] {ECO:0000313|EMBL:SNQ25993.1} RP NUCLEOTIDE SEQUENCE. RA Kim H.J., Triplett B.A.; RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases. RN [25] {ECO:0000313|EMBL:SNQ25993.1} RP NUCLEOTIDE SEQUENCE. RA Groeneweg M., Matern B., Palusci F., Meertens C., Tilanus M.G.J., RA Voorter C.E.M.; RT "Group specific, unambiguous full-length gene HLA Class I typing by RT Sanger sequencing: a robust SSBT Strategy for typing and a golden RT reference for next generation sequencing approaches."; RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases. RN [26] {ECO:0000313|EMBL:SOT92898.1} RP NUCLEOTIDE SEQUENCE. RA Hurst M.R.H.; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. RN [27] {ECO:0000313|EMBL:ASE99681.1} RP NUCLEOTIDE SEQUENCE. RA Hurley C.K., Hou L., Lazaro A., Gerfen J., Enriquez E., Galarza P., RA Rodriguez Cardozo M.B., Halagan M., Maiers M., Behm D., Ng J.; RT "Next generation sequencing characterizes the extent of HLA diversity RT in an Argentinian registry population."; RL HLA. 91:175-186(2018). RN [28] {ECO:0000313|EMBL:SFV42124.1} RP NUCLEOTIDE SEQUENCE. RA Marsh S.G.E.; RT "Full-length genomic HLA sequences."; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [29] {ECO:0000313|EMBL:AUZ98368.1} RP NUCLEOTIDE SEQUENCE. RA Lazaro A.M., Hou L., Enriquez E., Persaud M., Hurley C.K.; RT "Novel HLA Class I alleles."; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [30] {ECO:0000313|EMBL:AVV63103.1} RP NUCLEOTIDE SEQUENCE. RA Lazaro A.M., Hou L., Enriquez E., Persaud M., Hurley C.K.; RT "Novel HLA Class I alleles."; RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases. RN [31] {ECO:0000313|EMBL:SPI58569.1} RP NUCLEOTIDE SEQUENCE. RA Keele B.F.; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. RN [32] {ECO:0000313|EMBL:SPS67918.1} RP NUCLEOTIDE SEQUENCE. RA Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., RA Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Rusch D., RA Podicherti R., Tsui H.-C.T., Winkler M.E.; RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL662833; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC033293; AAH33293.1; -; mRNA. DR EMBL; GQ472838; ACV91118.1; -; Genomic_DNA. DR EMBL; GQ472839; ACV91119.1; -; Genomic_DNA. DR EMBL; KU528607; ALZ40822.1; -; Genomic_DNA. DR EMBL; KU319188; ANG08604.1; -; Genomic_DNA. DR EMBL; KU319189; ANG08605.1; -; Genomic_DNA. DR EMBL; KY622045; ASE99681.1; -; Genomic_DNA. DR EMBL; KY626050; ASE99686.1; -; Genomic_DNA. DR EMBL; KY419402; ASU50293.1; -; Genomic_DNA. DR EMBL; KY419403; ASU50294.1; -; Genomic_DNA. DR EMBL; KY419404; ASU50295.1; -; Genomic_DNA. DR EMBL; KY419405; ASU50296.1; -; Genomic_DNA. DR EMBL; MF981006; ATV81380.1; -; Genomic_DNA. DR EMBL; KY499646; AUN50126.1; -; Genomic_DNA. DR EMBL; MG747476; AUZ98368.1; -; Genomic_DNA. DR EMBL; MG779942; AVC68922.1; -; Genomic_DNA. DR EMBL; MG944953; AVV63103.1; -; Genomic_DNA. DR EMBL; MG911201; AWC68084.1; -; Genomic_DNA. DR EMBL; D83957; BAA22206.1; -; Genomic_DNA. DR EMBL; BA000025; BAB63310.1; -; Genomic_DNA. DR EMBL; AB774946; BAN59792.1; -; Genomic_DNA. DR EMBL; HE793165; CCG58319.1; -; Genomic_DNA. DR EMBL; HF565303; CCP37718.1; -; Genomic_DNA. DR EMBL; HG794375; CDK41184.1; -; Genomic_DNA. DR EMBL; HG794378; CDK41187.1; -; Genomic_DNA. DR EMBL; LK021963; CDQ51644.1; -; Genomic_DNA. DR EMBL; LN600112; CEF48102.2; -; Genomic_DNA. DR EMBL; LN624510; CEH11580.1; -; Genomic_DNA. DR EMBL; LN811470; CEP25297.1; -; Genomic_DNA. DR EMBL; LN832568; CQR91446.1; -; Genomic_DNA. DR EMBL; LN877368; CUA55111.1; -; Genomic_DNA. DR EMBL; LN912841; CUU97168.1; -; Genomic_DNA. DR EMBL; LN912851; CUU97178.1; -; Genomic_DNA. DR EMBL; LN912882; CUU97209.1; -; Genomic_DNA. DR EMBL; LN912964; CUU97291.1; -; Genomic_DNA. DR EMBL; LN912965; CUU97292.1; -; Genomic_DNA. DR EMBL; LN912966; CUU97293.1; -; Genomic_DNA. DR EMBL; LN912967; CUU97294.1; -; Genomic_DNA. DR EMBL; LN912968; CUU97295.1; -; Genomic_DNA. DR EMBL; LT575524; SBL08196.1; -; Genomic_DNA. DR EMBL; LT599302; SBW38523.1; -; Genomic_DNA. DR EMBL; LT599310; SBW38531.1; -; Genomic_DNA. DR EMBL; LT599317; SBW38538.1; -; Genomic_DNA. DR EMBL; LT599328; SBW38549.1; -; Genomic_DNA. DR EMBL; LT618799; SCQ83615.1; -; Genomic_DNA. DR EMBL; LT627695; SFV42124.1; -; Genomic_DNA. DR EMBL; LT898183; SNQ25993.1; -; Genomic_DNA. DR EMBL; LT964794; SOT92898.1; -; Genomic_DNA. DR EMBL; LT964813; SOT92917.1; -; Genomic_DNA. DR EMBL; LT964820; SOT92924.1; -; Genomic_DNA. DR EMBL; LT964841; SOT92945.1; -; Genomic_DNA. DR EMBL; LT964849; SOT92953.1; -; Genomic_DNA. DR EMBL; LT964853; SOT92957.1; -; Genomic_DNA. DR EMBL; LT966143; SOU90297.1; -; Genomic_DNA. DR EMBL; LT966190; SOU90344.1; -; Genomic_DNA. DR EMBL; LT966196; SOU90350.1; -; Genomic_DNA. DR EMBL; LT966226; SOU90380.1; -; Genomic_DNA. DR EMBL; LT966290; SOU90444.1; -; Genomic_DNA. DR EMBL; LT966291; SOU90445.1; -; Genomic_DNA. DR EMBL; LT966393; SOU94030.1; -; Genomic_DNA. DR EMBL; LT990031; SPI58569.1; -; Genomic_DNA. DR EMBL; LS453233; SPS67918.1; -; Genomic_DNA. DR EMBL; LS453256; SPS67946.1; -; Genomic_DNA. DR EMBL; LS453267; SPS67963.1; -; Genomic_DNA. DR RefSeq; NP_001229971.1; NM_001243042.1. DR UniGene; Hs.656020; -. DR UniGene; Hs.743218; -. DR DNASU; 3107; -. DR Ensembl; ENST00000424832; ENSP00000414063; ENSG00000233841. DR GeneID; 3107; -. DR UCSC; uc011fcf.3; human. DR CTD; 3107; -. DR H-InvDB; HIX0151763; -. DR HGNC; HGNC:4933; HLA-C. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR ChiTaRS; HLA-C; human. DR GenomeRNAi; 3107; -. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:O19617, KW ECO:0000213|MaxQB:O19617, ECO:0000213|PeptideAtlas:O19617}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015096743. FT TRANSMEM 308 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 40711 MW; 0B9518E6AA77A609 CRC64; MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC SNSAQGSDES LITCKA // ID P79568_MOUSE Unreviewed; 326 AA. AC P79568; DT 01-MAY-1997, integrated into UniProtKB/TrEMBL. DT 01-MAY-1997, sequence version 1. DT 12-SEP-2018, entry version 164. DE SubName: Full=Class Ib MHC antigen Qa-2 {ECO:0000313|EMBL:AAB41658.1}; DE SubName: Full=Histocompatibility 2, Q region locus 6 {ECO:0000313|Ensembl:ENSMUSP00000109511}; GN Name=H2-Q6 {ECO:0000313|Ensembl:ENSMUSP00000109511, GN ECO:0000313|MGI:MGI:95935}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAB41658.1}; RN [1] {ECO:0000313|EMBL:AAB41658.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/10 {ECO:0000313|EMBL:AAB41658.1}; RX PubMed=6088985; DOI=10.1038/310650a0; RA Weiss E.H., Golden L., Fahrner K., Mellor A.L., Devlin J.J., RA Bullman H., Tiddens H., Bud H., Flavell R.A.; RT "Organization and evolution of the class I gene family in the major RT histocompatibility complex of the C57BL/10 mouse."; RL Nature 310:650-655(1984). RN [2] {ECO:0000313|EMBL:AAB41658.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/10 {ECO:0000313|EMBL:AAB41658.1}; RX PubMed=8952959; DOI=10.1007/s002510050177; RA Cai W., Cao W., Wu L., Exley G.E., Waneck G.L., Karger B.L., RA Warner C.M.; RT "Sequence and transcription of Qa-2-encoding genes in mouse RT lymphocytes and blastocysts."; RL Immunogenetics 45:97-107(1996). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000109511, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000109511, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000134550} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134550}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [5] {ECO:0000313|Ensembl:ENSMUSP00000109511} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000109511}; RG Ensembl; RL Submitted (DEC-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR974466; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; U57393; AAB41658.1; -; Genomic_DNA. DR RefSeq; NP_997531.1; NM_207648.1. DR UniGene; Mm.439827; -. DR UniGene; Mm.486287; -. DR DNASU; 110557; -. DR Ensembl; ENSMUST00000113879; ENSMUSP00000109511; ENSMUSG00000073409. DR Ensembl; ENSMUST00000174699; ENSMUSP00000134550; ENSMUSG00000073409. DR GeneID; 110557; -. DR KEGG; mmu:110557; -. DR UCSC; uc008chp.2; mouse. DR CTD; 110557; -. DR MGI; MGI:95935; H2-Q6. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; WMEREGR; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000073409; Expressed in 145 organ(s), highest expression level in lymph node. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; ISO:MGI. DR GO; GO:0042277; F:peptide binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0046977; F:TAP binding; ISO:MGI. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Proteomics identification {ECO:0000213|EPD:P79568}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 326 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015096862. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 326 AA; 37407 MW; B5DF577A21ED85FF CRC64; MALTTLLLLV AAALTLIETR AGPHSLRYFH TAVSWPGLVE PRFIIVGYVD NKQFVRFDSD AENPRMEPRA RWMEQEGPEY WERETQKAKG HEESFRVSLR TAQRYYNQSK GGSHTLQWMY GCDVGSDERL LRGYLQFAYE GRDYIALNED LKTWTAADMA AQITLHKWEQ AGIAERDRAY LEGACVQSLR RYLQLRKETL LCTDPPKAHV THHPRSYGAV TLRCWALGFY PADITLTWQL NGEELTQDME LVETRPAGDG TFQKWASVVV PLGKEQNYTC HVNHEGLPEP LTLRWEPPPS TVSNMANVAI LVVLVAWPSL ELWWIL // ID Q05A75_MOUSE Unreviewed; 384 AA. AC Q05A75; DT 14-NOV-2006, integrated into UniProtKB/TrEMBL. DT 14-NOV-2006, sequence version 1. DT 12-SEP-2018, entry version 117. DE SubName: Full=H-2 class I histocompatibility antigen, TLA(B) alpha chain {ECO:0000313|Ensembl:ENSMUSP00000099736}; DE SubName: Full=Histocompatibility 2, T region locus 3 {ECO:0000313|EMBL:AAI25381.1}; DE SubName: Full=MCG132399 {ECO:0000313|EMBL:EDL23281.1}; GN Name=H2-T3 {ECO:0000313|EMBL:AAI25381.1, GN ECO:0000313|Ensembl:ENSMUSP00000099736, ECO:0000313|MGI:MGI:95959}; GN ORFNames=mCG_132399 {ECO:0000313|EMBL:EDL23281.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI25381.1}; RN [1] {ECO:0000313|EMBL:EDL23281.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL23281.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [2] {ECO:0000313|EMBL:AAI25381.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain {ECO:0000313|EMBL:AAI25381.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] {ECO:0000313|EMBL:EDL23281.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL23281.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSMUSP00000099736, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000099736, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [5] {ECO:0000313|Ensembl:ENSMUSP00000099736} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000099736}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CT030728; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC125378; AAI25379.1; -; mRNA. DR EMBL; BC125380; AAI25381.1; -; mRNA. DR EMBL; CH466559; EDL23281.1; -; Genomic_DNA. DR RefSeq; NP_032234.3; NM_008208.4. DR UniGene; Mm.426002; -. DR Ensembl; ENSMUST00000102675; ENSMUSP00000099736; ENSMUSG00000054128. DR Ensembl; ENSMUST00000173133; ENSMUSP00000134469; ENSMUSG00000054128. DR GeneID; 15043; -. DR KEGG; mmu:15043; -. DR UCSC; uc008ckm.1; mouse. DR CTD; 15043; -. DR MGI; MGI:95959; H2-T3. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000054128; Expressed in 15 organ(s), highest expression level in colon. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:Q05A75, KW ECO:0000213|PeptideAtlas:Q05A75}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 384 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015096888. FT TRANSMEM 315 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 384 AA; 43544 MW; CC32654364B26218 CRC64; MRMGTMVPGT LLILLAASQG QTQTCPGSHS LRYFYTALSR PAISEPWYIA VGYLDDTQFV RFNSSGETAT YKLSAPWVEQ EGPEYWARET EIVTSNAQFF RENLQTMLDY YNLSQNGSHT IQVMYGCEVE FFGSLFRAYE QHGYDGRDYI ALNEDLKTWT AADTAAEITR SKWEQAGYTE LRRTYLEGPC KDSLLRYLEN RKKTQECTDP PKTHVTHHPR PEGYVTLRCW ALRFYPADIT LTWQLNGEEL IQDTELVETR PAGDGTFQKW AAVVVPLGKE QKYTCHVYHE GLPEPLTLRW EPPQTSMPNR TTVRALLGAM IILGFMSGSV MMWMRKNNGG NGDDNTAAYQ NEREHLSLSP RAESEALGVE AGMKDLPSAP PLVS // ID Q0WXH6_MOUSE Unreviewed; 285 AA. AC Q0WXH6; E9PV42; E9Q5B3; DT 05-SEP-2006, integrated into UniProtKB/TrEMBL. DT 18-MAR-2008, sequence version 2. DT 12-SEP-2018, entry version 115. DE SubName: Full=MHC class Ib T9 {ECO:0000313|EMBL:BAF02291.2}; GN Name=Gm7030 {ECO:0000313|Ensembl:ENSMUSP00000040558, GN ECO:0000313|MGI:MGI:3647514}; GN Synonyms=EG630294 {ECO:0000313|MGI:MGI:3647514}, GN Gm11127 {ECO:0000313|MGI:MGI:3647514}, GN H2-T9 {ECO:0000313|EMBL:BAF02291.2}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAF02291.2}; RN [1] {ECO:0000313|EMBL:BAF02291.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57black/6j {ECO:0000313|EMBL:BAF02291.2}; RX PubMed=18416856; DOI=10.1186/1471-2164-9-178; RA Ohtsuka M., Inoko H., Kulski J.K., Yoshimura S.; RT "Major histocompatibility complex (Mhc) class Ib gene duplications, RT organization and expression patterns in mouse strain C57BL/6."; RL BMC Genomics 9:178-178(2008). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000040558, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000040558, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000133748} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133748}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. RN [4] {ECO:0000313|Ensembl:ENSMUSP00000040558} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000040558}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CT030728; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AB267093; BAF02291.2; -; mRNA. DR RefSeq; NP_001170938.1; NM_001177467.1. DR UniGene; Mm.484916; -. DR STRING; 10090.ENSMUSP00000040558; -. DR Ensembl; ENSMUST00000046131; ENSMUSP00000040558; ENSMUSG00000092243. DR Ensembl; ENSMUST00000172968; ENSMUSP00000133748; ENSMUSG00000092243. DR Ensembl; ENSMUST00000173322; ENSMUSP00000133734; ENSMUSG00000092243. DR GeneID; 630294; -. DR KEGG; mmu:630294; -. DR UCSC; uc012asl.1; mouse. DR MGI; MGI:3647514; Gm7030. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; DEGHEYT; -. DR OrthoDB; EOG091G0KRD; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000092243; Expressed in 12 organ(s), highest expression level in colon. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 285 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015097016. FT DOMAIN 207 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 285 AA; 32574 MW; 667BBB00432A20A9 CRC64; MGTLTSCPLL LLLLATALAP TRAGKSSHSL RYFATAMSRP GLGEPRFTAV GYVDDTQFMR FDSDSENPRA EPCKPWVEQM EPEYWEQETR KFKEHTQNFR TCLYNLLHLY NQSQDGPHTI QDMHGCYVGP DGQFLHGHYQ HAYDGHDYIT LNEDLSSWTA ADAVAQITQH KWEEAGVAEE YKAYLEGTCV ETLHRLLEEA QQHSDPPNTH VTRHPRPEGE VTLRCWALGF YPADITLTWQ LNGEELTQDM ELVETRPAGD GTFQKWAAVV VPFGEEPRYT CHVYH // ID Q198H2_PANTR Unreviewed; 366 AA. AC Q198H2; DT 11-JUL-2006, integrated into UniProtKB/TrEMBL. DT 11-JUL-2006, sequence version 1. DT 12-SEP-2018, entry version 101. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:ABG02219.1}; GN Name=Patr-C {ECO:0000313|EMBL:ABG02219.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|EMBL:ABG02219.1}; RN [1] {ECO:0000313|EMBL:ABG02219.1} RP NUCLEOTIDE SEQUENCE. RA Walker C.M.; RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ASK05168.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28623392; RA Maibach V., Hans J.B., Hvilsom C., Marques-Bonet T., Vigilant L.; RT "MHC class I diversity in chimpanzees and bonobos."; RL Immunogenetics 0:0-0(2017). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DQ539680; ABG02219.1; -; mRNA. DR EMBL; KY613155; ASK05168.1; -; Genomic_DNA. DR RefSeq; NP_001012441.2; NM_001012439.2. DR UniGene; Ptr.2993; -. DR STRING; 9598.ENSPTRP00000054564; -. DR GeneID; 471962; -. DR KEGG; ptr:471962; -. DR CTD; 471962; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Bgee; ENSPTRG00000041261; Expressed in 6 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013530821. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 40697 MW; 5F746ED03F32D458 CRC64; MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTAVSRPG RGEPHFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWHRETQK YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ WMYGCDLGPD GRLLRGYDQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGLCVE WLRRYLENGR ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWGP SSQPTIPIVG IAAGLAVLAV LAVLGAVVAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA // ID Q29897_HUMAN Unreviewed; 154 AA. AC Q29897; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 12-SEP-2018, entry version 123. DE SubName: Full=B2 microglobulin {ECO:0000313|EMBL:AAA58654.1}; GN Name=HLA-G3 {ECO:0000313|EMBL:AAA58654.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAA58654.1}; RN [1] {ECO:0000313|EMBL:AAA58654.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Placenta {ECO:0000313|EMBL:AAA58654.1}; RX PubMed=1570318; DOI=10.1073/pnas.89.9.3947; RA Ishitani A., Geraghty D.E.; RT "Alternative splicing of HLA-G transcripts yields proteins with RT primary structures resembling both class I and class II antigens."; RL Proc. Natl. Acad. Sci. U.S.A. 89:3947-3951(1992). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; M90686; AAA58654.1; -; mRNA. DR UniGene; Hs.512152; -. DR SMR; Q29897; -. DR PeptideAtlas; Q29897; -. DR PRIDE; Q29897; -. DR UCSC; uc010jrn.3; human. DR EuPathDB; HostDB:ENSG00000204632.11; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOGENOM; HOG000206851; -. DR HOVERGEN; HBG016709; -. DR Bgee; ENSG00000204632; Expressed in 233 organ(s), highest expression level in blood. DR ExpressionAtlas; Q29897; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 2: Evidence at transcript level; SQ SEQUENCE 154 AA; 17070 MW; CECFCC7616238134 CRC64; MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM NLQTLRGYYN QSEAKQSSLP TIPIMGIVAG LVVLAAVVTG AAVAAVLWRK KSSD // ID Q30486_HORSE Unreviewed; 346 AA. AC Q30486; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 12-SEP-2018, entry version 139. DE SubName: Full=MHC Class I heavy chain {ECO:0000313|EMBL:CAA56265.1}; GN Name=EQMHCC1 {ECO:0000313|EMBL:CAA56265.1, GN ECO:0000313|Ensembl:ENSECAP00000018161}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|EMBL:CAA56265.1}; RN [1] {ECO:0000313|EMBL:CAA56265.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=8547231; DOI=10.1111/j.1744-313X.1995.tb00239.x; RA Ellis S.A., Martin A.J., Holmes E.C., Morrison W.I.; RT "At least four MHC class I genes are transcribed in the horse: RT phylogenetic analysis suggests an unusual evolutionary history for the RT MHC in this species."; RL Eur. J. Immunogenet. 22:249-260(1995). RN [2] {ECO:0000313|Ensembl:ENSECAP00000018161, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018161, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [3] {ECO:0000313|Ensembl:ENSECAP00000018161} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018161}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X79893; CAA56265.1; -; mRNA. DR RefSeq; NP_001075976.1; NM_001082507.1. DR UniGene; Eca.12488; -. DR Ensembl; ENSECAT00000021999; ENSECAP00000018161; ENSECAG00000019928. DR GeneID; 100034211; -. DR KEGG; ecb:100034211; -. DR CTD; 100034211; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR Proteomes; UP000002281; Chromosome 20. DR Bgee; ENSECAG00000019928; Expressed in 3 organ(s), highest expression level in liver. DR ExpressionAtlas; Q30486; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 346 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014104433. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 346 AA; 38814 MW; C029781EBFCF17DB CRC64; MRVIAPRTLM VLLSGALALT KTWAGSHSMR YFSTAVSRPG RGESWYLEVG YVDDTQFVRF DSDAASPRME PRAPWMEQEG PEYWEEETQR AAGLAHSFRG NLNNLRGYYN QSEAGSHTLQ LMYGCDVGPH GRLLSASFQY AYDGADYLAL NEDLRSWTAA DTAAQISKRK KEVAGNAKYW RNYLEGTCVK WLSRYLENGK ETLQRADPPK THVTHHPISD SEVTLRCWAL AFYPAEITLT WQHIGEDLTQ DMELVETRPS GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPIILRWEP SHESIIHILG IVAGLVLLLV TGAVVAVIWR KKHSDGKGGS YAQAAT // ID Q31093_MOUSE Unreviewed; 336 AA. AC Q31093; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 12-SEP-2018, entry version 156. DE SubName: Full=Histocompatibility 2, M region locus 3 {ECO:0000313|EMBL:EDL23336.1, ECO:0000313|Ensembl:ENSMUSP00000035687}; DE SubName: Full=MHC class I antigen H-2M3 {ECO:0000313|EMBL:AAA60335.1}; GN Name=H2-M3 {ECO:0000313|EMBL:EDL23336.1, GN ECO:0000313|Ensembl:ENSMUSP00000035687, ECO:0000313|MGI:MGI:95915}; GN Synonyms=H-2M3 {ECO:0000313|EMBL:AAA60335.1}; GN ORFNames=mCG_23393 {ECO:0000313|EMBL:EDL23336.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAA60335.1}; RN [1] {ECO:0000313|EMBL:AAA60335.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Thymus {ECO:0000313|EMBL:AAA60335.1}; RX PubMed=1855254; DOI=10.1016/0092-8674(91)90623-7; RA Wang C.R., Loveland B.E., Lindahl K.F.; RT "H-2M3 encodes the MHC class I molecule presenting the maternally RT transmitted antigen of the mouse."; RL Cell 66:335-345(1991). RN [2] {ECO:0000313|EMBL:AAA60335.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Thymus {ECO:0000313|EMBL:AAA60335.1}; RA Rishi A.K., Gulamhussein A., Steele M.P.; RL Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000213|PDB:1MHC} RP X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 25-298, AND DISULFIDE BONDS. RX PubMed=7664344; DOI=10.1016/0092-8674(95)90037-3; RA Wang C.R., Castano A.R., Peterson P.A., Slaughter C., Lindahl K.F., RA Deisenhofer J.; RT "Nonclassical binding of formylated peptide in crystal structure of RT the MHC class Ib molecule H2-M3."; RL Cell 82:655-664(1995). RN [4] {ECO:0000313|EMBL:EDL23336.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL23336.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [5] {ECO:0000313|EMBL:EDL23336.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL23336.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|Ensembl:ENSMUSP00000035687} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000035687}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [7] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [8] {ECO:0000313|Ensembl:ENSMUSP00000035687} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000035687}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CT033782; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; U18797; AAA60335.1; -; mRNA. DR EMBL; CH466559; EDL23336.1; -; Genomic_DNA. DR RefSeq; NP_038847.1; NM_013819.2. DR UniGene; Mm.14437; -. DR PDB; 1MHC; X-ray; 2.10 A; A/D=25-298. DR PDBsum; 1MHC; -. DR STRING; 10090.ENSMUSP00000035687; -. DR Ensembl; ENSMUST00000038580; ENSMUSP00000035687; ENSMUSG00000016206. DR GeneID; 14991; -. DR KEGG; mmu:14991; -. DR UCSC; uc008cmo.1; mouse. DR CTD; 14991; -. DR MGI; MGI:95915; H2-M3. DR eggNOG; ENOG410KII2; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; EYFRAYV; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000016206; Expressed in 177 organ(s), highest expression level in spleen. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0032398; C:MHC class Ib protein complex; IDA:MGI. DR GO; GO:0042802; F:identical protein binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; IDA:MGI. DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0002287; P:alpha-beta T cell activation involved in immune response; IMP:MGI. DR GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; IDA:MGI. DR GO; GO:0002477; P:antigen processing and presentation of exogenous peptide antigen via MHC class Ib; IDA:MGI. DR GO; GO:0002481; P:antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; IDA:MGI. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0042742; P:defense response to bacterium; IDA:MGI. DR GO; GO:0002767; P:immune response-inhibiting cell surface receptor signaling pathway; ISO:MGI. DR GO; GO:2001199; P:negative regulation of dendritic cell differentiation; ISO:MGI. DR GO; GO:0042130; P:negative regulation of T cell proliferation; ISO:MGI. DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IMP:MGI. DR GO; GO:0032735; P:positive regulation of interleukin-12 production; ISO:MGI. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IMP:MGI. DR GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IMP:MGI. DR GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; ISO:MGI. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI. DR GO; GO:0002666; P:positive regulation of T cell tolerance induction; ISO:MGI. DR GO; GO:0002645; P:positive regulation of tolerance induction; ISO:MGI. DR GO; GO:0002237; P:response to molecule of bacterial origin; IDA:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0000213|PDB:1MHC}; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:Q31093, KW ECO:0000213|MaxQB:Q31093}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 336 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015097374. FT TRANSMEM 306 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT CARBOHYD 110 110 N-linked (GlcNAc...) asparagine. FT {ECO:0000213|PDB:1MHC}. FT DISULFID 125 188 {ECO:0000213|PDB:1MHC}. FT DISULFID 227 283 {ECO:0000213|PDB:1MHC}. SQ SEQUENCE 336 AA; 37856 MW; F0EE53DA1D8D98C8 CRC64; MGSSSNRALL HMVVVSLAVT QTGSGSHSLR YFHTAVSRPG RGEPQYISVG YVDDVQFQRC DSIEEIPRME PRAPWMEKER PEYWKELKLK VKNIAQSARA NLRTLLRYYN QSEGGSHILQ WMVSCEVGPD MRLLGAHYQA AYDGSDYITL NEDLSSWTAV DMVSQITKSR LESAGTAEYF RAYVEGECLE LLHRFLRNGK EILQRADPPK AHVAHHPRPK GDVTLRCWAL GFYPADITLT WQKDEEDLTQ DMELVETRPS GDGTFQKWAA VVVPSGEEQR YTCYVHHEGL TEPLALKWGR SSQSSVVIMV IVASLVLLGG VITIVVVCKR RGAGER // ID Q31611_HUMAN Unreviewed; 246 AA. AC Q31611; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 12-SEP-2018, entry version 154. DE SubName: Full=B2 microglobulin {ECO:0000313|EMBL:AAA58653.1}; DE SubName: Full=HLA class I histocompatibility antigen, alpha chain G {ECO:0000313|Ensembl:ENSP00000366014}; GN Name=HLA-G {ECO:0000313|EMBL:AAA59836.1, GN ECO:0000313|Ensembl:ENSP00000366014}; GN Synonyms=HLA-G2.2 {ECO:0000313|EMBL:AAA58653.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAA58653.1}; RN [1] {ECO:0000313|EMBL:AAA58653.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Placenta {ECO:0000313|EMBL:AAA58653.1}; RX PubMed=1570318; DOI=10.1073/pnas.89.9.3947; RA Ishitani A., Geraghty D.E.; RT "Alternative splicing of HLA-G transcripts yields proteins with RT primary structures resembling both class I and class II antigens."; RL Proc. Natl. Acad. Sci. U.S.A. 89:3947-3951(1992). RN [2] {ECO:0000313|Ensembl:ENSP00000366014, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [3] {ECO:0000313|Ensembl:ENSP00000366014} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [4] {ECO:0000313|Ensembl:ENSP00000373118} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL645929; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL671561; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX001005; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX247949; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX927141; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759769; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR788234; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CT009517; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; M90685; AAA58653.1; -; mRNA. DR EMBL; M90684; AAA59836.1; -; mRNA. DR RefSeq; XP_016866306.1; XM_017010817.1. DR RefSeq; XP_016866307.1; XM_017010818.1. DR UniGene; Hs.512152; -. DR SMR; Q31611; -. DR MaxQB; Q31611; -. DR PRIDE; Q31611; -. DR Ensembl; ENST00000376818; ENSP00000366014; ENSG00000204632. DR Ensembl; ENST00000383623; ENSP00000373118; ENSG00000206506. DR Ensembl; ENST00000412263; ENSP00000397733; ENSG00000237216. DR Ensembl; ENST00000426863; ENSP00000392075; ENSG00000235680. DR Ensembl; ENST00000430253; ENSP00000396594; ENSG00000233095. DR Ensembl; ENST00000434907; ENSP00000408461; ENSG00000233095. DR Ensembl; ENST00000452577; ENSP00000415905; ENSG00000235346. DR Ensembl; ENST00000452715; ENSP00000390678; ENSG00000230413. DR Ensembl; ENST00000466488; ENSP00000433426; ENSG00000237216. DR Ensembl; ENST00000467814; ENSP00000434622; ENSG00000235680. DR Ensembl; ENST00000469347; ENSP00000437036; ENSG00000235346. DR Ensembl; ENST00000469472; ENSP00000432220; ENSG00000206506. DR Ensembl; ENST00000478519; ENSP00000436375; ENSG00000204632. DR Ensembl; ENST00000486553; ENSP00000432239; ENSG00000230413. DR GeneID; 3135; -. DR UCSC; uc003nnz.4; human. DR CTD; 3135; -. DR EuPathDB; HostDB:ENSG00000204632.11; -. DR HGNC; HGNC:4964; HLA-G. DR OpenTargets; ENSG00000204632; -. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR ChiTaRS; HLA-G; human. DR GenomeRNAi; 3135; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204632; Expressed in 233 organ(s), highest expression level in blood. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:Q31611, KW ECO:0000213|PeptideAtlas:Q31611}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 246 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014586278. FT TRANSMEM 216 240 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 117 195 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 246 AA; 27680 MW; C9B1F92620203909 CRC64; MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM NLQTLRGYYN QSEANPPKTH VTHHPVFDYE ATLRCWALGF YPAEIILTWQ RDGEDQTQDV ELVETRPAGD GTFQKWAAVV VPSGEEQRYT CHVQHEGLPE PLMLRWKQSS LPTIPIMGIV AGLVVLAAVV TGAAVAAVLW RKKSSD // ID Q31615_MOUSE Unreviewed; 379 AA. AC Q31615; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 12-SEP-2018, entry version 178. DE SubName: Full=Histocompatibility 2, T region locus 22 {ECO:0000313|Ensembl:ENSMUSP00000077111}; GN Name=H2-T22 {ECO:0000313|Ensembl:ENSMUSP00000077111, GN ECO:0000313|MGI:MGI:95956}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAA39691.1}; RN [1] {ECO:0000313|EMBL:AAA39691.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=2379238; DOI=10.1016/0092-8674(90)90019-B; RA Kouichi I., Kaer L.V., Bonneville M., Hsu S., Murphy D.B., RA Tonegawa S.; RT "Recognition of the product of a novel MHC TL region gene (27-b) by a RT mouse gamma-delta T cell receptor."; RL Cell 62:549-561(1990). RN [2] {ECO:0000313|EMBL:BAE21968.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE21968.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:BAE21968.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [3] {ECO:0000313|EMBL:BAE21968.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE21968.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:BAE21968.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [4] {ECO:0000313|EMBL:BAE21968.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE21968.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:BAE21968.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [5] {ECO:0000213|PDB:1C16} RP X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 29-286, AND DISULFIDE BONDS. RX PubMed=10634787; DOI=10.1126/science.287.5451.310; RA Wingren C., Crowley M.P., Degano M., Chien Y., Wilson I.A.; RT "Crystal structure of a gammadelta T cell receptor ligand T22: a RT truncated MHC-like fold."; RL Science 287:310-314(2000). RN [6] {ECO:0000313|EMBL:BAE21968.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE21968.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:BAE21968.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [7] {ECO:0000313|EMBL:BAE21968.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE21968.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:BAE21968.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [8] {ECO:0000313|EMBL:BAE21968.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE21968.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:BAE21968.1}; RA Chen C.-T., Hsu E.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:BAE21968.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE21968.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:BAE21968.1}; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [10] {ECO:0000313|EMBL:BAE21968.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE21968.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:BAE21968.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [11] {ECO:0000313|Ensembl:ENSMUSP00000077111} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000077111}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [12] {ECO:0000313|Ensembl:ENSMUSP00000077111} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000077111}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC112970; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; M35243; AAA39690.1; -; mRNA. DR EMBL; M35245; AAA39691.1; -; mRNA. DR EMBL; AK133985; BAE21968.1; -; mRNA. DR PIR; A35878; A35878. DR PIR; PS0138; PS0138. DR RefSeq; NP_034527.1; NM_010397.4. DR RefSeq; XP_006523764.1; XM_006523701.2. DR UniGene; Mm.195061; -. DR PDB; 1C16; X-ray; 3.10 A; A/C/E/G=29-288. DR PDBsum; 1C16; -. DR STRING; 10090.ENSMUSP00000077111; -. DR Ensembl; ENSMUST00000077960; ENSMUSP00000077111; ENSMUSG00000056116. DR Ensembl; ENSMUST00000080015; ENSMUSP00000078927; ENSMUSG00000056116. DR GeneID; 15039; -. DR UCSC; uc008cjw.1; mouse. DR CTD; 15039; -. DR MGI; MGI:95956; H2-T22. DR GeneTree; ENSGT00740000114936; -. DR HOVERGEN; HBG016709; -. DR OMA; WIWIVAM; -. DR OrthoDB; EOG091G0M1Y; -. DR TreeFam; TF336617; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000056116; Expressed in 80 organ(s), highest expression level in basioccipital bone. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0000213|PDB:1C16}; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:Q31615}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 379 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015097384. FT TRANSMEM 295 317 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 197 275 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DISULFID 126 176 {ECO:0000213|PDB:1C16}. FT DISULFID 135 158 {ECO:0000213|PDB:1C16}. FT DISULFID 215 271 {ECO:0000213|PDB:1C16}. SQ SEQUENCE 379 AA; 43256 MW; 158F75832CED91DA CRC64; MSWVLRAAVV CALLLQLDAR PSWTRIPLGS HSLRYFYTAV SRPGLGEPWF IIVGYVDDMQ VLRFSSKEET PRMAPWLEQE EADNWEQQTR IVTIQGQLSE RNLMTLVHFY NKSMDDSHTL QWLQGCDVEP DRHLCLWYNQ LAYDSEDLPT LNENPSSCTV GNSTVPHISQ DLKSHCSDLL QKYLEKGKER LLRSDPPKAH VTRHPRPEGD VTLRCWALGF YPADITLTWQ LNGEELTQDM ELVETRPAGD GTFQKWAAVV VPLGKEQSYT CHVYHEGLPE PLILRWEPAW YQKPWIWIVA MVFILFIICL CVVCICMKKN AGGRGRRDTQ EAGRDSPQDS SKTVVDDEEM GVCFWKIKSC KTCLGHSPGT SVGESLLSP // ID Q3B8R6_RAT Unreviewed; 296 AA. AC Q3B8R6; DT 22-NOV-2005, integrated into UniProtKB/TrEMBL. DT 22-NOV-2005, sequence version 1. DT 12-SEP-2018, entry version 112. DE SubName: Full=Alpha-2-glycoprotein 1, zinc {ECO:0000313|EMBL:EDL83887.1}; DE SubName: Full=Alpha-2-glycoprotein 1, zinc-binding {ECO:0000313|EMBL:AAI05823.1}; DE SubName: Full=Zinc-alpha-2-glycoprotein {ECO:0000313|Ensembl:ENSRNOP00000001801}; GN Name=Azgp1 {ECO:0000313|EMBL:AAI05823.1, GN ECO:0000313|Ensembl:ENSRNOP00000001801, ECO:0000313|RGD:2187}; GN ORFNames=rCG_55974 {ECO:0000313|EMBL:EDL83887.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAI05823.1}; RN [1] {ECO:0000313|EMBL:AAI05823.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Liver {ECO:0000313|EMBL:AAI05823.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000001801, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000001801, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [3] {ECO:0000313|EMBL:EDL83887.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL83887.1}; RX PubMed=15632090; DOI=10.1101/gr.2889405; RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., RA Istrail S., Li P., Sutton G.; RT "Gene and alternative splicing annotation with AIR."; RL Genome Res. 15:54-66(2005). RN [4] {ECO:0000313|EMBL:EDL83887.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL83887.1}; RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., RA Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., RA Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|Ensembl:ENSRNOP00000001801} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000001801}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07035540; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC105822; AAI05823.1; -; mRNA. DR EMBL; CH474107; EDL83887.1; -; Genomic_DNA. DR RefSeq; NP_036958.2; NM_012826.2. DR UniGene; Rn.5007; -. DR Ensembl; ENSRNOT00000001801; ENSRNOP00000001801; ENSRNOG00000001333. DR GeneID; 25294; -. DR KEGG; rno:25294; -. DR CTD; 563; -. DR RGD; 2187; Azgp1. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOVERGEN; HBG016709; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Reactome; R-RNO-5223345; Miscellaneous transport and binding events. DR Proteomes; UP000002494; Chromosome 12. DR Bgee; ENSRNOG00000001333; Expressed in 7 organ(s), highest expression level in liver. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q3B8R6}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 296 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015297487. FT DOMAIN 202 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 296 AA; 34034 MW; 1618067DDAA14E3A CRC64; MVPVLLSLPL LLGPAVLQET GSYSLIFLYT GLSRPSKGLL RFQATAFLND QAFFHYNSNS GKAEPVEPWS HVEGMEDWEK ESQLQRAREE IFLVTLKDIM DYYEDSTGSH TFQGMFGCEI TNNRSSGAVW RYAYDGEDFI EFNKEIPAWI PLDPAAANTK LKWEAEKVYV QRAKAYLEEE CPTMLKKYLT YSRSHLDRTD PPTVKITSRV APGRNRIFRC LAYDFYPQRI SLHWNQASKK LASEPERGVF PNGNGTYLSW MEVEVPPQNR DPFVCHIEHK GLSQSLSVQW DEKSKV // ID Q3T119_BOVIN Unreviewed; 354 AA. AC Q3T119; DT 11-OCT-2005, integrated into UniProtKB/TrEMBL. DT 11-OCT-2005, sequence version 1. DT 12-SEP-2018, entry version 120. DE SubName: Full=FCGRT protein {ECO:0000313|EMBL:AAI02160.1}; DE SubName: Full=Fc fragment of IgG receptor and transporter {ECO:0000313|Ensembl:ENSBTAP00000018500}; GN Name=FCGRT {ECO:0000313|EMBL:AAI02160.1, GN ECO:0000313|Ensembl:ENSBTAP00000018500, ECO:0000313|VGNC:VGNC:28934}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI02160.1}; RN [1] {ECO:0000313|EMBL:AAI02160.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Crossbred x Angus {ECO:0000313|EMBL:AAI02160.1}; RC TISSUE=Ileum {ECO:0000313|EMBL:AAI02160.1}; RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y., RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C., RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J., RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J., RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., RA Siddiqui A., Holt R., Jones S.J., Marra M.A.; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSBTAP00000018500, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000018500, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [3] {ECO:0000313|Ensembl:ENSBTAP00000018500} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000018500}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02047478; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC102159; AAI02160.1; -; mRNA. DR RefSeq; NP_788830.1; NM_176657.1. DR RefSeq; XP_005219232.1; XM_005219175.3. DR RefSeq; XP_005219233.1; XM_005219176.3. DR UniGene; Bt.1035; -. DR SMR; Q3T119; -. DR STRING; 9913.ENSBTAP00000018500; -. DR Ensembl; ENSBTAT00000018500; ENSBTAP00000018500; ENSBTAG00000013926. DR Ensembl; ENSBTAT00000043155; ENSBTAP00000040745; ENSBTAG00000013926. DR GeneID; 338062; -. DR KEGG; bta:338062; -. DR CTD; 2217; -. DR VGNC; VGNC:28934; FCGRT. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000112560; -. DR HOVERGEN; HBG100415; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR TreeFam; TF336617; -. DR Proteomes; UP000009136; Chromosome 18. DR Bgee; ENSBTAG00000013926; Expressed in 9 organ(s), highest expression level in liver. DR ExpressionAtlas; Q3T119; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; IBA:GO_Central. DR GO; GO:0019864; F:IgG binding; IEA:Ensembl. DR GO; GO:0019770; F:IgG receptor activity; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 354 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014104639. FT TRANSMEM 299 320 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 201 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 354 AA; 39143 MW; A2860DADD4758115 CRC64; MRLPRPQPWG LGLLLVLLPG ALSAENYRSL QYHFTAVSAP AAGTPAFWVS GWLGPQQYLS YNNLRAQAEP YGAWVWESQV SWYWEKETMD LRNQETLFLE ALQALGEGPF TMQGLLGCEL GPDNVSVPVA KFALNGEEFM MFDPKLGIWD GDWPESRTVS IKWTQQPEAV NKEKTFLLYS CPHRLLGHLE RGRGNLEWKE PPSMRLKARP GSPGFSVLTC SAFSFYPPEL KLRFLRNGLA IGSGEIDMGP NGDGSFYAWS SLTVKSGDEH HYRCVVQHAG LAQPLTVELE SPARTSVPVV GIVIGLFLLL TVAAGGALLW RRMRKGLPAP WISFRGEDVG ALLPTPGLSK DGES // ID Q3TH01_MOUSE Unreviewed; 360 AA. AC Q3TH01; DT 11-OCT-2005, integrated into UniProtKB/TrEMBL. DT 11-OCT-2005, sequence version 1. DT 12-SEP-2018, entry version 141. DE SubName: Full=H-2 class I histocompatibility antigen, K-K alpha chain {ECO:0000313|Ensembl:ENSMUSP00000134004}; GN Name=H2-K1 {ECO:0000313|Ensembl:ENSMUSP00000134004, GN ECO:0000313|MGI:MGI:95904}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE40397.1}; RN [1] {ECO:0000313|EMBL:BAE40397.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE40397.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAE40397.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAE40397.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE40397.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAE40397.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAE40397.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE40397.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAE40397.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAE40397.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE40397.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAE40397.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAE40397.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE40397.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAE40397.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [6] {ECO:0000313|EMBL:BAE40397.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE40397.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAE40397.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., RA Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., RA Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., RA Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., RA Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., RA Muramatsu M., Hayashizaki Y.; RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:BAE40397.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE40397.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAE40397.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] {ECO:0000313|EMBL:BAE40397.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE40397.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAE40397.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [9] {ECO:0000213|PubMed:17242355} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=17242355; DOI=10.1073/pnas.0609836104; RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; RT "Large-scale phosphorylation analysis of mouse liver."; RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). RN [10] {ECO:0000313|Ensembl:ENSMUSP00000134004, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134004, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [11] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [12] {ECO:0000313|Ensembl:ENSMUSP00000134004} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134004}; RG Ensembl; RL Submitted (JAN-2013) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR974462; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AK168517; BAE40397.1; -; mRNA. DR RefSeq; NP_001334275.1; NM_001347346.1. DR UniGene; Mm.422886; -. DR UniGene; Mm.439675; -. DR UniGene; Mm.440940; -. DR UniGene; Mm.441651; -. DR UniGene; Mm.466882; -. DR Ensembl; ENSMUST00000172912; ENSMUSP00000134004; ENSMUSG00000061232. DR GeneID; 14972; -. DR UCSC; uc008caq.1; mouse. DR CTD; 14972; -. DR MGI; MGI:95904; H2-K1. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR ChiTaRS; H2-K1; mouse. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000061232; Expressed in 279 organ(s), highest expression level in epididymal fat pad. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0042605; F:peptide antigen binding; IEA:Ensembl. DR GO; GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IEA:Ensembl. DR GO; GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; IEA:Ensembl. DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0048839; P:inner ear development; IEA:Ensembl. DR GO; GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:Q3TH01, KW ECO:0000213|MaxQB:Q3TH01, ECO:0000213|PeptideAtlas:Q3TH01}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 360 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015097436. FT TRANSMEM 305 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 360 AA; 40286 MW; D115FCD057E59359 CRC64; MVPCTLLLLL AAALAPTQTR AGPHSLRYFV TAVSRPGLGE PRYMEVGYVD DTEFVRFDSD AENPRYEPRA RWMEQEGPEY WERETQKAKG NEQSFRVDLR TLLGYYNQSK GGSHTIQVIS GCEVGSDGRL LRGYQQYAYD GCDYIALNED LKTWTAADMA ALITKHKWEQ AGEAERLRAY LEGTCVEWLR RYLKNGNATL LRTDSPKAHV THHSRPEDKV TLRCWALGFY PADITLTWQL NGEELIQDME LVETRPAGDG TFQKWASVVV PLGKEQYYTC HVYHQGLPEP LTLRWEPPPS TVSNMATVAV LVVLGAAIVT GAVVAFVMKM RRRNTGGKGG DYALAPGSQT SDLSLPDCKA // ID Q4FZX6_RAT Unreviewed; 365 AA. AC Q4FZX6; DT 30-AUG-2005, integrated into UniProtKB/TrEMBL. DT 30-AUG-2005, sequence version 1. DT 12-SEP-2018, entry version 123. DE SubName: Full=RT1 class I, locus CE10 {ECO:0000313|Ensembl:ENSRNOP00000070126}; DE SubName: Full=RT1-CE10 protein {ECO:0000313|EMBL:AAH98952.1}; GN Name=RT1-CE10 {ECO:0000313|EMBL:AAH98952.1, GN ECO:0000313|Ensembl:ENSRNOP00000070126, ECO:0000313|RGD:1359292}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAH98952.1}; RN [1] {ECO:0000313|EMBL:AAH98952.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Spleen {ECO:0000313|EMBL:AAH98952.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000070126, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000070126, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [3] {ECO:0000313|Ensembl:ENSRNOP00000070126} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000070126}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044242; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC098952; AAH98952.1; -; mRNA. DR RefSeq; XP_006255909.1; XM_006255847.3. DR UniGene; Rn.219012; -. DR PRIDE; Q4FZX6; -. DR Ensembl; ENSRNOT00000079494; ENSRNOP00000070126; ENSRNOG00000050210. DR GeneID; 414792; -. DR CTD; 414792; -. DR RGD; 1359292; RT1-CE10. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR TreeFam; TF336617; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000050210; Expressed in 9 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q4FZX6}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 365 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015297718. FT TRANSMEM 315 336 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 365 AA; 41508 MW; D9F04647C337DDE2 CRC64; MEAMARPTLL LLLAAALAPT KTRAGSHWMR YFHTAVSRPG LGEPRYISVG YVDDTQFVRF DSDAENPRYE PRARWMEREG PEYWERNTRI VKGKEQIFRD NLRTLLGYYN QSEGGSHTLQ LMYGCDVGSD WSLLRGYEQH AYDGRDYIAL NEDLKTWAAA DFEAQKTRSK WEREGVAERS RAYLEGECVK WLRRHLEHGK EALLRLDPPE AHVTLHPRPE GDVTLRCWAL GFYPADITLT WQLNGEDLTQ DMEFVETRPA GDGTFQKWAS VVVPLGKEQN YTCLVEHEGL PEPLTQRWEP SPSTNTNMGI DVTSVFLGPL AVFVVLAIIG AAVAVVRRRR RRNTGGEGGD YTPAPVMVYD SRSPA // ID Q4G002_RAT Unreviewed; 373 AA. AC Q4G002; DT 30-AUG-2005, integrated into UniProtKB/TrEMBL. DT 30-AUG-2005, sequence version 1. DT 12-SEP-2018, entry version 124. DE SubName: Full=Histocompatibility 2, T region locus 24 {ECO:0000313|EMBL:AAH98866.1}; DE SubName: Full=RT1 class I, locus T24, gene 4 {ECO:0000313|Ensembl:ENSRNOP00000043387}; GN Name=RT1-T24-4 {ECO:0000313|Ensembl:ENSRNOP00000043387, GN ECO:0000313|RGD:1598233}; GN Synonyms=H2-T24 {ECO:0000313|EMBL:AAH98866.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAH98866.1}; RN [1] {ECO:0000313|EMBL:AAH98866.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Thymus {ECO:0000313|EMBL:AAH98866.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000043387, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000043387, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [3] {ECO:0000313|Ensembl:ENSRNOP00000043387} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000043387}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044362; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC098866; AAH98866.1; -; mRNA. DR RefSeq; NP_001008826.2; NM_001008826.3. DR UniGene; Rn.224465; -. DR SMR; Q4G002; -. DR STRING; 10116.ENSRNOP00000043387; -. DR PRIDE; Q4G002; -. DR Ensembl; ENSRNOT00000047439; ENSRNOP00000043387; ENSRNOG00000042905. DR GeneID; 414784; -. DR KEGG; rno:414784; -. DR CTD; 414784; -. DR RGD; 1598233; RT1-T24-4. DR eggNOG; ENOG410J90V; Eukaryota. DR eggNOG; ENOG41117CA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; TSRMKIF; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000042905; Expressed in 10 organ(s), highest expression level in lung. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 313 339 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 373 AA; 42461 MW; CAB400EDDB4413CD CRC64; MWALIFCFLS HPRDTGARSH SLHYSYSAVT EPGPGVPAFF ASGFVDNQPF IHYDSRKMEA EPCADWLREN PYYFDEETQV FTNRMKIFQL SLRNIQQYYN SSGDRSQRAD GFHQQAGPHT LQFTYGCEMQ DNRTTGHWQY GYDGRDYLTL DLDSMQYTAA TFIAGYTKHK WQNNEYWLER EKTYLEKECV LWLKRYLTMG GENFTRTDPP QTTVTHHPRP EGDVTLRCWA LGFYPADITL TWQLNGEDLT QEMELVETRP AGDGTFQKWA SVVVPLGKEQ KYTCHVEHEG LPEPLTQRWE PPSSTDSNME TNVIYVVVGA VSAVAIIGAV IIGAVVAVVR KRRRNTGGKG VYAPAPGRDS CQSSDVSLPD CEA // ID Q4KN81_MOUSE Unreviewed; 360 AA. AC Q4KN81; DT 02-AUG-2005, integrated into UniProtKB/TrEMBL. DT 02-AUG-2005, sequence version 1. DT 12-SEP-2018, entry version 142. DE SubName: Full=Histocompatibility 2, Q region locus 2 {ECO:0000313|EMBL:AAI38689.1, ECO:0000313|Ensembl:ENSMUSP00000078138}; DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:AAY85367.1}; GN Name=H2-Q2 {ECO:0000313|EMBL:AAY85367.1, GN ECO:0000313|Ensembl:ENSMUSP00000078138, ECO:0000313|MGI:MGI:95931}; GN Synonyms=Gm11132 {ECO:0000313|MGI:MGI:95931}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAY85367.1}; RN [1] {ECO:0000313|EMBL:AAI38689.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain {ECO:0000313|EMBL:AAI38689.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|EMBL:AAY85367.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=B6.Kb-/-Db-/- {ECO:0000313|EMBL:AAY85367.1}; RC TISSUE=Small intestine {ECO:0000313|EMBL:AAY85367.1}; RX PubMed=16210630; RA Guidry P.A., Stroynowski I.; RT "The murine family of gut-restricted class Ib MHC includes RT alternatively spliced isoforms of the proposed HLA-G homolog, RT "blastocyst MHC"."; RL J. Immunol. 175:5248-5259(2005). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000078138, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000078138, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [5] {ECO:0000313|Ensembl:ENSMUSP00000078138} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000078138}; RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR974466; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC138688; AAI38689.1; -; mRNA. DR EMBL; BC138689; AAI38690.1; -; mRNA. DR EMBL; AY989880; AAY85367.1; -; mRNA. DR RefSeq; NP_034522.2; NM_010392.2. DR UniGene; Mm.427969; -. DR STRING; 10090.ENSMUSP00000078138; -. DR Ensembl; ENSMUST00000074806; ENSMUSP00000078138; ENSMUSG00000091705. DR GeneID; 15013; -. DR KEGG; mmu:15013; -. DR UCSC; uc008chl.1; mouse. DR CTD; 15013; -. DR MGI; MGI:95931; H2-Q2. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; DEICAPW; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000091705; Expressed in 81 organ(s), highest expression level in epithelium of small intestine. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; ISO:MGI. DR GO; GO:0042277; F:peptide binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0046977; F:TAP binding; ISO:MGI. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0007565; P:female pregnancy; IMP:MGI. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0035264; P:multicellular organism growth; IMP:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 360 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015097622. FT TRANSMEM 304 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 360 AA; 40431 MW; D6718F726872A49D CRC64; MALRRLLLLL VAALKLTETR AGSHSLRYFT TAVSRPGLGE PRFIIVGYVD DTQFVRFDSD AENPRMEPRA PWMEQEGPEY WERNTQVSKE NEQSFRVSLG TALSYYNQSK GGSHTLQWLV GCDLGPDGSL LRGYEQSAYD GRDYLALNED LITWTAADLA ALKTRSKLEQ AGLAEKRRAY LEVDCLTWLR RYLELGKETL LHTDPPKAHV THHPSSQGDV TLRCWALGFY PADITLTWQL NGEDLTQDME LVETRPSGDG TFQKWASVMV PFGEEPRYTC HVEHEGLPEP LTLRWEPPPS TDSYMVIIAV LVVLGAVIII GAVVAFVMKR GRNTGGKVRD YAQDPGRDSP QSSDISLLEL // ID Q4T1U3_TETNG Unreviewed; 97 AA. AC Q4T1U3; DT 19-JUL-2005, integrated into UniProtKB/TrEMBL. DT 19-JUL-2005, sequence version 1. DT 28-MAR-2018, entry version 65. DE SubName: Full=Chromosome undetermined SCAF10480, whole genome shotgun sequence {ECO:0000313|EMBL:CAF93139.1}; DE Flags: Fragment; GN ORFNames=GSTENG00008642001 {ECO:0000313|EMBL:CAF93139.1}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|EMBL:CAF93139.1}; RN [1] {ECO:0000313|EMBL:CAF93139.1, ECO:0000313|Ensembl:ENSTNIP00000007590} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|EMBL:CAF93139.1} RP NUCLEOTIDE SEQUENCE. RG Genoscope; RG Whitehead Institute Centre for Genome Research; RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSTNIP00000007590} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CAAE01010480; CAF93139.1; -; Genomic_DNA. DR Ensembl; ENSTNIT00000007750; ENSTNIP00000007590; ENSTNIG00000004925. DR KEGG; tng:GSTEN00008642G001; -. DR GeneTree; ENSGT00900000141162; -. DR OMA; WDSETEI; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF352996; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}. FT DOMAIN 2 88 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:CAF93139.1}. SQ SEQUENCE 97 AA; 11222 MW; 0ECCC84944D5A803 CRC64; THTLKYFHTV SSGVPNFPEF VAVVMVDDVH ISHYDSDTRR AQPRQEWMEN VSAEHPQYWE RETGNFMGAH QAYKAWIEIL KPSFNQTGGE MSSPLHC // ID Q5EEZ1_BOVIN Unreviewed; 356 AA. AC Q5EEZ1; E1BKY1; DT 15-MAR-2005, integrated into UniProtKB/TrEMBL. DT 15-MAR-2005, sequence version 1. DT 12-SEP-2018, entry version 119. DE SubName: Full=HFE {ECO:0000313|EMBL:AAW82001.1}; DE SubName: Full=Hemochromatosis {ECO:0000313|Ensembl:ENSBTAP00000017371}; GN Name=HFE {ECO:0000313|Ensembl:ENSBTAP00000017371, GN ECO:0000313|VGNC:VGNC:29831}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAW82001.1}; RN [1] {ECO:0000313|EMBL:AAW82001.1} RP NUCLEOTIDE SEQUENCE. RA De Juan Sanjuan C., Ellis S.A.; RT "Sequencing of the cattle HFE full length cDNA."; RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSBTAP00000017371, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000017371, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [3] {ECO:0000313|Ensembl:ENSBTAP00000017371} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000017371}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DAAA02055498; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AY898807; AAW82001.1; -; mRNA. DR RefSeq; NP_001012399.1; NM_001012399.1. DR UniGene; Bt.37142; -. DR SMR; Q5EEZ1; -. DR STRING; 9913.ENSBTAP00000017371; -. DR Ensembl; ENSBTAT00000017371; ENSBTAP00000017371; ENSBTAG00000013065. DR GeneID; 497622; -. DR KEGG; bta:497622; -. DR CTD; 3077; -. DR VGNC; VGNC:29831; HFE. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOVERGEN; HBG016709; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Reactome; R-BTA-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000009136; Chromosome 23. DR Bgee; ENSBTAG00000013065; Expressed in 10 organ(s), highest expression level in liver. DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl. DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:Ensembl. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl. DR GO; GO:0030881; F:beta-2-microglobulin binding; IEA:Ensembl. DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0071281; P:cellular response to iron ion; IEA:Ensembl. DR GO; GO:0042446; P:hormone biosynthetic process; IEA:Ensembl. DR GO; GO:0098711; P:iron ion import across plasma membrane; IBA:GO_Central. DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IEA:Ensembl. DR GO; GO:1904283; P:negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:Ensembl. DR GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; IEA:Ensembl. DR GO; GO:1900121; P:negative regulation of receptor binding; IEA:Ensembl. DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; IEA:Ensembl. DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR GO; GO:1904434; P:positive regulation of ferrous iron binding; IEA:Ensembl. DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl. DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl. DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IEA:Ensembl. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; IEA:Ensembl. DR GO; GO:1900390; P:regulation of iron ion import; IEA:Ensembl. DR GO; GO:2000008; P:regulation of protein localization to cell surface; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 356 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014105594. FT TRANSMEM 313 334 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 215 304 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 356 AA; 40644 MW; 20293131C61A2AAD CRC64; MGPRARPALL LLILLRTAAT QGRPPRSHSL RFLFMGASKP DLGLPLFEAL GYVDDQLFVS YDHESRRAER RAPWLWGRAT SQLWLQLSQN LKGWDHMFIV DFWTIMDNHN QSKVTKLGAL PESHTLQVIL GCELQEDNST RGFWKYGYDG QDHLEFRPET LDWRAAEPRA QVTKLEWEVN KIRAKQNRAY LDRDCPEQLL HLLELGRGPL EQQVPPLVKV THHVTSSLTT LRCRALNFYP QNITIRWLKD KQFLDAKEIK PEDVLPNGDG TYQAWVALAM LPGEEQRYSC QVEHPGLDQP LTATWEPSLS GTLVTGILSG IAVCVIIFLI GILFRILKRR QSSRGAAVNY ALAECE // ID Q5RJ85_HUMAN Unreviewed; 343 AA. AC Q5RJ85; DT 05-FEB-2008, integrated into UniProtKB/TrEMBL. DT 05-FEB-2008, sequence version 1. DT 12-SEP-2018, entry version 100. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain G {ECO:0000313|Ensembl:ENSP00000366024}; DE SubName: Full=HLA-G histocompatibility antigen, class I, G, isoform CRA_b {ECO:0000313|EMBL:EAX03232.1}; GN Name=HLA-G {ECO:0000313|EMBL:EAX03232.1, GN ECO:0000313|Ensembl:ENSP00000366024}; GN ORFNames=hCG_1999524 {ECO:0000313|EMBL:EAX03232.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000366024, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|EMBL:EAX03232.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11181995; DOI=10.1126/science.1058040; RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., RA Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., RA Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G., RA Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., RA Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., RA Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., RA Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., RA Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., RA Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., RA Brandon R., Cargill M., Chandramouliswaran I., Charlab R., RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., RA Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., RA Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., RA Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., RA Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., RA Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., RA Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., RA Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., RA Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., RA Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., RA Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., RA Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., RA Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., RA Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., RA Kline L., Koduru S., Love A., Mann F., May D., McCawley S., RA McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., RA Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., RA Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., RA Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., RA Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., RA Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., RA Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., RA Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., RA Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., RA Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., RA Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., RA Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., RA Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., RA Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., RA McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., RA Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.; RT "The sequence of the human genome."; RL Science 291:1304-1351(2001). RN [2] {ECO:0000313|Ensembl:ENSP00000366024, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [3] {ECO:0000313|EMBL:EAX03232.1} RP NUCLEOTIDE SEQUENCE. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSP00000366024} RP IDENTIFICATION. RG Ensembl; RL Submitted (AUG-2012) to UniProtKB. RN [5] {ECO:0000313|Ensembl:ENSP00000383506} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL645929; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL671561; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX001005; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX247949; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX927141; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759769; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR788234; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CT009517; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471081; EAX03232.1; -; Genomic_DNA. DR EMBL; CH471081; EAX03233.1; -; Genomic_DNA. DR EMBL; CH471081; EAX03236.1; -; Genomic_DNA. DR RefSeq; XP_016866305.1; XM_017010816.1. DR UniGene; Hs.512152; -. DR EPD; Q5RJ85; -. DR MaxQB; Q5RJ85; -. DR PRIDE; Q5RJ85; -. DR Ensembl; ENST00000376828; ENSP00000366024; ENSG00000204632. DR Ensembl; ENST00000400665; ENSP00000383506; ENSG00000230413. DR Ensembl; ENST00000400682; ENSP00000383521; ENSG00000206506. DR Ensembl; ENST00000420559; ENSP00000397331; ENSG00000235346. DR Ensembl; ENST00000422371; ENSP00000387624; ENSG00000235680. DR Ensembl; ENST00000434881; ENSP00000392347; ENSG00000233095. DR Ensembl; ENST00000450984; ENSP00000409132; ENSG00000237216. DR GeneID; 3135; -. DR UCSC; uc003raj.4; human. DR CTD; 3135; -. DR EuPathDB; HostDB:ENSG00000204632.11; -. DR HGNC; HGNC:4964; HLA-G. DR OpenTargets; ENSG00000204632; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR OMA; VTHHPVF; -. DR OrthoDB; EOG091G09OH; -. DR ChiTaRS; HLA-G; human. DR GenomeRNAi; 3135; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204632; Expressed in 233 organ(s), highest expression level in blood. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:Q5RJ85, KW ECO:0000213|MaxQB:Q5RJ85, ECO:0000213|PeptideAtlas:Q5RJ85}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 343 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014586848. FT TRANSMEM 313 337 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 343 AA; 38838 MW; D9EEDC7C207AE9C5 CRC64; MKTPRMVVMA PRTLFLLLSG ALTLTETWAG SHSMRYFSAA VSRPGRGEPR FIAMGYVDDT QFVRFDSDSA CPRMEPRAPW VEQEGPEYWE EETRNTKAHA QTDRMNLQTL RGYYNQSEAS SHTLQWMIGC DLGSDGRLLR GYEQYAYDGK DYLALNEDLR SWTAADTAAQ ISKRKCEAAN VAEQRRAYLE GTCVEWLHRY LENGKEMLQR ADPPKTHVTH HPVFDYEATL RCWALGFYPA EIILTWQRDG EDQTQDVELV ETRPAGDGTF QKWAAVVVPS GEEQRYTCHV QHEGLPEPLM LRWKQSSLPT IPIMGIVAGL VVLAAVVTGA AVAAVLWRKK SSD // ID Q5SRN5_HUMAN Unreviewed; 371 AA. AC Q5SRN5; DT 21-DEC-2004, integrated into UniProtKB/TrEMBL. DT 20-FEB-2007, sequence version 2. DT 12-SEP-2018, entry version 127. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000366002}; GN Name=HLA-A {ECO:0000313|Ensembl:ENSP00000366002}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000366002, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000366002, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000366002} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [4] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [5] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL671277; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; Q5SRN5; -. DR EPD; Q5SRN5; -. DR MaxQB; Q5SRN5; -. DR PeptideAtlas; Q5SRN5; -. DR PRIDE; Q5SRN5; -. DR Ensembl; ENST00000376806; ENSP00000366002; ENSG00000206503. DR UCSC; uc063moy.1; human. DR EuPathDB; HostDB:ENSG00000206503.11; -. DR HGNC; HGNC:4931; HLA-A. DR OpenTargets; ENSG00000206503; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G09OH; -. DR PhylomeDB; Q5SRN5; -. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000206503; Expressed in 239 organ(s), highest expression level in mononuclear cell. DR ExpressionAtlas; Q5SRN5; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:Q5SRN5, KW ECO:0000213|MaxQB:Q5SRN5, ECO:0000213|PeptideAtlas:Q5SRN5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 371 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004262692. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 371 AA; 41368 MW; 7278E8DA0CD72CD5 CRC64; MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV DLGTLRGYYN QSEAGSHTIQ IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAAHEAEQL RAYLDGTCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSGGE GVKDRKGGSY TQAASSDSAQ GSDVSLTACK V // ID Q5SRN7_HUMAN Unreviewed; 299 AA. AC Q5SRN7; DT 21-DEC-2004, integrated into UniProtKB/TrEMBL. DT 20-FEB-2007, sequence version 2. DT 12-SEP-2018, entry version 114. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000365998}; GN Name=HLA-A {ECO:0000313|Ensembl:ENSP00000365998}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000365998, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000365998, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000365998} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [4] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [5] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL671277; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; Q5SRN7; -. DR EPD; Q5SRN7; -. DR PeptideAtlas; Q5SRN7; -. DR PRIDE; Q5SRN7; -. DR Ensembl; ENST00000376802; ENSP00000365998; ENSG00000206503. DR UCSC; uc063mpa.1; human. DR EuPathDB; HostDB:ENSG00000206503.11; -. DR HGNC; HGNC:4931; HLA-A. DR OpenTargets; ENSG00000206503; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000206503; Expressed in 239 organ(s), highest expression level in mononuclear cell. DR ExpressionAtlas; Q5SRN7; baseline and differential. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Proteomics identification {ECO:0000213|EPD:Q5SRN7, KW ECO:0000213|MaxQB:Q5SRN7, ECO:0000213|PeptideAtlas:Q5SRN7}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 299 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004261884. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 299 AA; 34211 MW; F79092B88499B77A CRC64; MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV DLGTLRGYYN QSEAGSHTIQ IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAAHEAEQL RAYLDGTCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWV // ID Q5SZ87_MOUSE Unreviewed; 271 AA. AC Q5SZ87; DT 21-DEC-2004, integrated into UniProtKB/TrEMBL. DT 21-DEC-2004, sequence version 1. DT 12-SEP-2018, entry version 124. DE SubName: Full=Hemochromatosis, isoform CRA_a {ECO:0000313|EMBL:EDL32542.1}; DE SubName: Full=Hereditary hemochromatosis protein homolog {ECO:0000313|Ensembl:ENSMUSP00000089299}; GN Name=Hfe {ECO:0000313|EMBL:EDL32542.1, GN ECO:0000313|Ensembl:ENSMUSP00000089299, ECO:0000313|MGI:MGI:109191}; GN ORFNames=mCG_7725 {ECO:0000313|EMBL:EDL32542.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000089299, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|EMBL:EDL32542.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL32542.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [2] {ECO:0000313|EMBL:EDL32542.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL32542.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSMUSP00000089299, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000089299, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [5] {ECO:0000313|Ensembl:ENSMUSP00000089299} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000089299}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL590388; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL592149; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH466561; EDL32542.1; -; Genomic_DNA. DR RefSeq; NP_001334422.1; NM_001347493.1. DR UniGene; Mm.2681; -. DR Ensembl; ENSMUST00000091707; ENSMUSP00000089299; ENSMUSG00000006611. DR GeneID; 15216; -. DR CTD; 3077; -. DR MGI; MGI:109191; Hfe. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000000589; Chromosome 13. DR Bgee; ENSMUSG00000006611; Expressed in 203 organ(s), highest expression level in epididymal fat pad. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0042446; P:hormone biosynthetic process; IEA:Ensembl. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:Ensembl. DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IEA:Ensembl. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:Q5SZ87, KW ECO:0000213|PeptideAtlas:Q5SZ87}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 271 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015098026. FT TRANSMEM 228 252 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 131 220 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 271 AA; 30128 MW; 0A2567D97D190BA3 CRC64; MSLSAGLPVR PLLLLLLLLW SVAPQALPPL TKLGVVSESH ILQVVLGCEV HEDNSTSGFW RYGYDGQDHL EFCPKTLNWS AAEPGAWATK VEWDEHKIRA KQNRDYLEKD CPEQLKRLLE LGRGVLGQQV PTLVKVTRHW ASTGTSLRCQ ALDFFPQNIT MRWLKDNQPL DAKDVNPEKV LPNGDETYQG WLTLAVAPGD ETRFTCQVEH PGLDQPLTAS WEPLQSQAMI IGIISGVTVC AIFLVGILFL ILRKRKASGG TMGGYVLTDC E // ID Q5WR11_CANLF Unreviewed; 361 AA. AC Q5WR11; DT 23-NOV-2004, integrated into UniProtKB/TrEMBL. DT 23-NOV-2004, sequence version 1. DT 12-SEP-2018, entry version 126. DE SubName: Full=MHC class I DLA-64 precursor {ECO:0000313|Ensembl:ENSCAFP00000031410}; DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:AAR27883.1}; GN Name=DLA-64 {ECO:0000313|EMBL:AAR27883.1, GN ECO:0000313|Ensembl:ENSCAFP00000031410}; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615 {ECO:0000313|EMBL:AAR27883.1}; RN [1] {ECO:0000313|Ensembl:ENSCAFP00000031410, ECO:0000313|Proteomes:UP000002254} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000031410, RC ECO:0000313|Proteomes:UP000002254}; RX PubMed=16341006; DOI=10.1038/nature04338; RG Broad Sequencing Platform; RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., RA Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., RA Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F., RA Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., RA Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., RA Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., RA Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., RA Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., RA Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., RA Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., RA Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., RA Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., RA Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., RA Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., RA Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., RA Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., RA Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., RA Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., RA Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., RA Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., RA Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., RA Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., RA Marabella R., Maru K., Matthews C., McDonough S., Mehta T., RA Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., RA Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., RA Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., RA Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., RA Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., RA Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., RA Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., RA Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., RA Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., RA Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., RA Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., RA Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., RA Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.; RT "Genome sequence, comparative analysis and haplotype structure of the RT domestic dog."; RL Nature 438:803-819(2005). RN [2] {ECO:0000313|EMBL:AAR27883.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=15896203; DOI=10.1111/j.1399-0039.2005.00411.x; RA Wagner J.L., Palti Y., DiDario D., Faraco J.; RT "Sequence of the canine major histocompatibility complex region RT containing non-classical class I genes."; RL Tissue Antigens 65:549-555(2005). RN [3] {ECO:0000313|Ensembl:ENSCAFP00000031410} RP IDENTIFICATION. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000031410}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAEX03008212; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AY423389; AAR27883.1; -; Genomic_DNA. DR UniGene; Cfa.36643; -. DR STRING; 9615.ENSCAFP00000031410; -. DR PRIDE; Q5WR11; -. DR Ensembl; ENSCAFT00000036073; ENSCAFP00000031410; ENSCAFG00000000500. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-CFA-1236974; ER-Phagosome pathway. DR Reactome; R-CFA-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-CFA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-CFA-6798695; Neutrophil degranulation. DR Reactome; R-CFA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002254; Chromosome 12. DR Bgee; ENSCAFG00000000500; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002254}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002254}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 361 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015298235. FT TRANSMEM 306 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 361 AA; 40130 MW; 547CDFFB09244FC3 CRC64; MEVVMPRALL VLLSAALAVT LTRAGSHSLR FFHTAVSRPG RGDPLYISVG YVDDTQFLRF NSDAASPKVE PRARWMEQEG PEFWEEQTEI AKVHAQTSRS NLQTALGYYN QSEAGSHTFQ WTSGCDVGPD GRLLRGYEQF AYDGADYLAL DEDLRSWTAA DAAAQITRRK WEAAGAAQYY RVYLQGECVQ SLLKYLERGK ETLQRTDPPK IYLTRHPISD HEVTLRCWAL GFYPAEITLT WQRDGEDQTQ DTEVVDTRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL AEPVTRRWEP SPLSTIVIVS IAALVLLVVA GVIGAVIWRK QRSGGKGPGY SHAARDDSAQ GSDVSLTAPR V // ID Q60I18_RAT Unreviewed; 404 AA. AC Q60I18; DT 23-NOV-2004, integrated into UniProtKB/TrEMBL. DT 23-NOV-2004, sequence version 1. DT 12-SEP-2018, entry version 113. DE SubName: Full=MHC I-like leukocyte 1 {ECO:0000313|Ensembl:ENSRNOP00000033032}; DE SubName: Full=MHC class I-like located near the LRC, 1 {ECO:0000313|EMBL:BAD54762.1}; GN Name=Mill1 {ECO:0000313|EMBL:BAD54762.1, GN ECO:0000313|Ensembl:ENSRNOP00000033032, ECO:0000313|RGD:1311714}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:BAD54762.1}; RN [1] {ECO:0000313|EMBL:BAD54762.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN/SsN {ECO:0000313|EMBL:BAD54762.1}; RC TISSUE=Heart {ECO:0000313|EMBL:BAD54762.1}; RX PubMed=15162429; DOI=10.1002/eji.200424919; RA Watanabe Y., Maruoka T., Walter L., Kasahara M.; RT "Comparative genomics of the Mill family: a rapidly evolving MHC class RT I gene family."; RL Eur. J. Immunol. 34:1597-1607(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000033032, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000033032, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [3] {ECO:0000313|Ensembl:ENSRNOP00000033032} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000033032}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [4] {ECO:0000313|Ensembl:ENSRNOP00000071141} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071141}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC093995; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AB113962; BAD54762.1; -; mRNA. DR RefSeq; NP_001011931.1; NM_001011931.2. DR RefSeq; XP_008757128.1; XM_008758906.2. DR RefSeq; XP_008757129.1; XM_008758907.2. DR UniGene; Rn.144784; -. DR STRING; 10116.ENSRNOP00000033032; -. DR Ensembl; ENSRNOT00000035286; ENSRNOP00000033032; ENSRNOG00000017699. DR Ensembl; ENSRNOT00000083546; ENSRNOP00000071141; ENSRNOG00000017699. DR GeneID; 292671; -. DR KEGG; rno:292671; -. DR CTD; 266815; -. DR RGD; 1311714; Mill1. DR eggNOG; ENOG410J8UC; Eukaryota. DR eggNOG; ENOG4111ECF; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOVERGEN; HBG060058; -. DR OMA; VIVTFRN; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF339076; -. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000002494; Chromosome 1. DR Bgee; ENSRNOG00000017699; Expressed in 8 organ(s), highest expression level in skeletal muscle tissue. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 30 {ECO:0000256|SAM:SignalP}. FT CHAIN 31 404 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015298298. FT TRANSMEM 386 403 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 224 338 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 124 144 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 404 AA; 46422 MW; 238E6F5E04306EB7 CRC64; MMLSRDLRAE AAVRLWIMFL LLEDLLGACA VGDYQRRVPS APNTDIRNTL EKPRVTTQEV AGPHTLRYDL MALSLKLPEL PQVLIWRYFD DEPFLHYNES SNRTDSWEPR IKRHWRAMTW ARETEDLQEM VEQLKRMLAE VTGQKGQDKG LHILQATLGC ELQRNGSTRG FWHLGYDGRN LLTFDQKTLT WTMDMPFTQQ KKTFWEPRAP RADLVKTFLD DTCPAQLQRH LASLRSEPLD TGSPMVIVTF RNYPLGRVTL TCRAFNLYPH MATRGTLAWL QDRKLVKQKA FEPGTILPSG DRTYQIWVSI WVLPGQEPQF TCNLSYHGGN IEKRAVIVNT VSGEKTRQPS TSGVGGRVKK SLWTTMTTAF MVTSWTRKTG GDSTLLLLWW LLFFSTVLAV LTLV // ID Q6B0J5_HUMAN Unreviewed; 345 AA. AC Q6B0J5; DT 13-SEP-2004, integrated into UniProtKB/TrEMBL. DT 13-SEP-2004, sequence version 1. DT 12-SEP-2018, entry version 135. DE SubName: Full=HFE protein {ECO:0000313|EMBL:AAH74721.1}; DE SubName: Full=Hereditary hemochromatosis protein {ECO:0000313|Ensembl:ENSP00000419725}; GN Name=HFE {ECO:0000313|EMBL:AAH74721.1, GN ECO:0000313|Ensembl:ENSP00000419725}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH74721.1}; RN [1] {ECO:0000313|Ensembl:ENSP00000419725, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|EMBL:AAH74721.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain {ECO:0000313|EMBL:AAH74721.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] {ECO:0000313|Ensembl:ENSP00000419725} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; U91328; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC074721; AAH74721.1; -; mRNA. DR UniGene; Hs.233325; -. DR SMR; Q6B0J5; -. DR MaxQB; Q6B0J5; -. DR PRIDE; Q6B0J5; -. DR Ensembl; ENST00000470149; ENSP00000419725; ENSG00000010704. DR UCSC; uc010jqe.2; human. DR EuPathDB; HostDB:ENSG00000010704.18; -. DR HGNC; HGNC:4886; HFE. DR OpenTargets; ENSG00000010704; -. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR GenomeRNAi; 3077; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000010704; Expressed in 196 organ(s), highest expression level in mononuclear cell. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:Q6B0J5, KW ECO:0000213|PeptideAtlas:Q6B0J5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 345 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014587234. FT TRANSMEM 302 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 188 283 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 345 AA; 39684 MW; E411C1A8E98B7BC9 CRC64; MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGASEQ DLGLSLFEAL GYVDDQLFVF YDHESRRVEP RTPWVSSRIS SQMWLQLSQS LKGWDHMFTV DFWTIMENHN HSKESHTLQV ILGCEMQEDN STEGYWKYGY DGQDHLEFCP DTLDWRAAEP RAWPTKLEWE RHKIRARQNR AYLERDCPAQ LQQLLELGRG VLDQQEGSES SSLPGKVTTL RCRALNYYPQ NITMKWLKDK QPMDAKEFEP KDVLPNGDGT YQGWITLAVP PGEEQRYTCQ VEHPGLDQPL IVIWEPSPSG TLVIGVISGI AVFVVILFIG ILFIILRKRQ GSRGAMGHYV LAERE // ID Q6DU44_HUMAN Unreviewed; 358 AA. AC Q6DU44; DT 10-MAY-2005, integrated into UniProtKB/TrEMBL. DT 10-MAY-2005, sequence version 1. DT 12-SEP-2018, entry version 147. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain E {ECO:0000313|Ensembl:ENSP00000365817}; DE SubName: Full=HLA-E protein {ECO:0000313|EMBL:BAF31260.1}; DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:ASU09661.1}; DE SubName: Full=MHC class Ib antigen {ECO:0000313|EMBL:AAT73214.1}; DE SubName: Full=Major histocompatibility complex, class I, E {ECO:0000313|EMBL:AAH40479.1}; GN Name=HLA-E {ECO:0000313|EMBL:AAT73214.1, GN ECO:0000313|Ensembl:ENSP00000365817}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAT73214.1}; RN [1] {ECO:0000313|Ensembl:ENSP00000365817, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|EMBL:AAH40479.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung {ECO:0000313|EMBL:AAH40479.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] {ECO:0000313|EMBL:AAT73214.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Afr-Am022 {ECO:0000313|EMBL:AAT73210.1}, RC Afr-Am024 {ECO:0000313|EMBL:AAT73214.1}, RC CEPH1408 {ECO:0000313|EMBL:AAT73216.1}, RC CEPH1416 {ECO:0000313|EMBL:AAT73219.1}, RC Sea-Cau-1 {ECO:0000313|EMBL:AAT73223.1}, and RC Sea-Cau-2 {ECO:0000313|EMBL:AAT73224.1}; RA Pyo C.-W., Ishitani A., Moore Y.F., Geraghty D.E.; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:BAF31260.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16702430; DOI=10.1534/genetics.106.057034; RA Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., RA Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., RA Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., RA Meyer A., Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., RA Gojobori T., Inoko H., Bahram S.; RT "Rapid evolution of major histocompatibility complex class I genes in RT primates generates new disease alleles in humans via hitchhiking RT diversity."; RL Genetics 173:1555-1570(2006). RN [5] {ECO:0000313|EMBL:AAT73214.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Afr-Am022 {ECO:0000313|EMBL:AAT73210.1}, RC Afr-Am024 {ECO:0000313|EMBL:AAT73214.1}, RC CEPH1408 {ECO:0000313|EMBL:AAT73216.1}, RC CEPH1416 {ECO:0000313|EMBL:AAT73219.1}, RC Sea-Cau-1 {ECO:0000313|EMBL:AAT73223.1}, and RC Sea-Cau-2 {ECO:0000313|EMBL:AAT73224.1}; RX PubMed=16570139; DOI=10.1007/s00251-005-0076-z; RA Pyo C.W., Williams L.M., Moore Y., Hyodo H., Li S.S., Zhao L.P., RA Sageshima N., Ishitani A., Geraghty D.E.; RT "HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines RT haplotype structure and variation spanning the nonclassical class I RT genes."; RL Immunogenetics 58:241-251(2006). RN [6] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [7] {ECO:0000313|Ensembl:ENSP00000365817} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [8] {ECO:0000313|EMBL:CDX10595.1} RP NUCLEOTIDE SEQUENCE. RA Voorter C.E.; RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:CDX10595.1} RP NUCLEOTIDE SEQUENCE. RA Olieslagers T.I., Groeneweg M., Wieten L., Arends R., Voorter C.E.M., RA Tilanus M.G.J.; RT "Full length HLA-E sequencing reveals new and null alleles."; RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|Ensembl:ENSP00000400458} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. RN [11] {ECO:0000313|EMBL:ASU09661.1} RP NUCLEOTIDE SEQUENCE. RA Xu Y., Wang S.; RT "Characterization of genomic full-length sequence of HLA-E in Chinese RT individuals."; RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:SCQ83612.1} RP NUCLEOTIDE SEQUENCE. RA Seilhamer J.J.; RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:SCQ83612.1} RP NUCLEOTIDE SEQUENCE. RA Olieslagers T.I., Voorter C.E.M., Groeneweg M., Xu Y., Wieten L., RA Tilanus M.G.J.; RT "New insights in HLA-E polymorphism by refined analysis of the full RT length gene."; RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL662873; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR382280; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR936916; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC040479; AAH40479.1; -; mRNA. DR EMBL; AY645727; AAT73210.1; -; Genomic_DNA. DR EMBL; AY645731; AAT73214.1; -; Genomic_DNA. DR EMBL; AY645733; AAT73216.1; -; Genomic_DNA. DR EMBL; AY645736; AAT73219.1; -; Genomic_DNA. DR EMBL; AY645737; AAT73220.1; -; Genomic_DNA. DR EMBL; AY645738; AAT73221.1; -; Genomic_DNA. DR EMBL; AY645740; AAT73223.1; -; Genomic_DNA. DR EMBL; AY645741; AAT73224.1; -; Genomic_DNA. DR EMBL; KX709624; ASU09661.1; -; Genomic_DNA. DR EMBL; AB103600; BAF31260.1; -; Genomic_DNA. DR EMBL; LM654512; CDX10595.1; -; Genomic_DNA. DR EMBL; LT618796; SCQ83612.1; -; Genomic_DNA. DR RefSeq; NP_005507.3; NM_005516.5. DR UniGene; Hs.650174; -. DR DNASU; 3133; -. DR Ensembl; ENST00000376630; ENSP00000365817; ENSG00000204592. DR Ensembl; ENST00000425603; ENSP00000402694; ENSG00000236632. DR Ensembl; ENST00000444683; ENSP00000400458; ENSG00000225201. DR GeneID; 3133; -. DR KEGG; hsa:3133; -. DR UCSC; uc003nqg.4; human. DR CTD; 3133; -. DR EuPathDB; HostDB:ENSG00000204592.8; -. DR HGNC; HGNC:4962; HLA-E. DR OpenTargets; ENSG00000204592; -. DR PharmGKB; PA35081; -. DR eggNOG; ENOG410JD1V; Eukaryota. DR eggNOG; ENOG410YKQA; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; SALTKTW; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR ChiTaRS; HLA-E; human. DR GenomeRNAi; 3133; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204592; Expressed in 235 organ(s), highest expression level in right lung. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:Q6DU44, KW ECO:0000213|MaxQB:Q6DU44, ECO:0000213|PeptideAtlas:Q6DU44}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 358 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014587264. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 358 AA; 40058 MW; 6B3001CA9F3B7FE3 CRC64; MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD DTQFVRFDND AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR TLRGYYNQSE AGSHTLQWMH GCELGPDGRF LRGYEQFAYD GKDYLTLNED LRSWTAVDTA AQISEQKSND ASEAEHQRAY LEDTCVEWLH KYLEKGKETL LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ DGEGHTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTLRWKPASQ PTIPIVGIIA GLVLLGSVVS GAVVAAVIWR KKSSGGKGGS YSKAEWSDSA QGSESHSL // ID Q6EM37_PIG Unreviewed; 247 AA. AC Q6EM37; F1S7T9; DT 16-AUG-2004, integrated into UniProtKB/TrEMBL. DT 16-AUG-2004, sequence version 1. DT 12-SEP-2018, entry version 88. DE SubName: Full=UL16 binding protein {ECO:0000313|EMBL:AAP81932.1}; GN Name=ULBP1 {ECO:0000313|EMBL:AAP81932.1}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|EMBL:AAP81932.1}; RN [1] {ECO:0000313|EMBL:AAP81932.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=15781110; DOI=10.1016/j.molimm.2004.09.020; RA Garcia-Borges C.N., Phanavanh B., Saraswati S., Dennis R.A., RA Crew M.D.; RT "Molecular cloning and characterization of a porcine UL16 binding RT protein (ULBP)-like cDNA."; RL Mol. Immunol. 42:665-671(2005). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AY248037; AAP81932.1; -; mRNA. DR RefSeq; NP_001004035.1; NM_001004035.1. DR UniGene; Ssc.42777; -. DR STRING; 9823.ENSSSCP00000004433; -. DR PaxDb; Q6EM37; -. DR GeneID; 445523; -. DR KEGG; ssc:445523; -. DR CTD; 80329; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR HOGENOM; HOG000070028; -. DR HOVERGEN; HBG052564; -. DR KO; K07986; -. DR OMA; CKMWLEE; -. DR OrthoDB; EOG091G0I62; -. DR TreeFam; TF341724; -. DR Bgee; ENSSSCG00000004100; Expressed in 3 organ(s), highest expression level in lung. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 2: Evidence at transcript level; SQ SEQUENCE 247 AA; 26974 MW; 24B97DB4FA122081 CRC64; MAQTAGSTAG LGFLSLLFSL RLCPAACDTH SLCYNFIIIP KPSPGHPWCV VQAQVDAEDF FSCDCGAAQI QSVSSLGEKV KGTKNWEIQI ETLKDVGDFL KEQLPDIMPE NYTAMDPPTL QVKVTCQSQD DGHTSGSWKF AFNGQICLHI DSDNMTLTVV HSGGRRMKEK WESDRIVTSF LRNISLGDCK SWLTHFLVHW EKMLKTAASP TTAPPIAHSK GAAIKPSAWF PLLVLVLAGL VPTVLLG // ID Q6GMG0_DANRE Unreviewed; 348 AA. AC Q6GMG0; DT 19-JUL-2004, integrated into UniProtKB/TrEMBL. DT 19-JUL-2004, sequence version 1. DT 12-SEP-2018, entry version 127. DE SubName: Full=Major histocompatibility complex class I UBA {ECO:0000313|Ensembl:ENSDARP00000020667}; DE SubName: Full=Major histocompatibility complex class I UBA protein {ECO:0000313|EMBL:AAH74095.1}; DE SubName: Full=Mhc1uba protein {ECO:0000313|EMBL:AAI64159.1}; GN Name=mhc1uba {ECO:0000313|EMBL:AAH74095.1, GN ECO:0000313|Ensembl:ENSDARP00000020667, GN ECO:0000313|ZFIN:ZDB-GENE-990415-145}; GN ORFNames=CH211-51F10.2-001 {ECO:0000313|EMBL:CAK04954.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH74095.1}; RN [1] {ECO:0000313|EMBL:AAH74095.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Whole {ECO:0000313|EMBL:AAH74095.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AAI64159.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=PCR rescue {ECO:0000313|EMBL:AAI64159.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:CAK04954.1} RP NUCLEOTIDE SEQUENCE. RA Howden P.; RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSDARP00000020667} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000020667}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [5] {ECO:0000313|Ensembl:ENSDARP00000020667, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000020667, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; FP074889; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC074095; AAH74095.1; -; mRNA. DR EMBL; BC164159; AAI64159.1; -; mRNA. DR EMBL; BX510994; CAK04954.1; -; Genomic_DNA. DR UniGene; Dr.75075; -. DR STRING; 7955.ENSDARP00000020667; -. DR Ensembl; ENSDART00000009689; ENSDARP00000020667; ENSDARG00000075963. DR ZFIN; ZDB-GENE-990415-145; mhc1uba. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOVERGEN; HBG016709; -. DR OMA; LENECIE; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Reactome; R-DRE-917977; Transferrin endocytosis and recycling. DR Proteomes; UP000000437; Chromosome 19. DR Bgee; ENSDARG00000075963; Expressed in 21 organ(s), highest expression level in head. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q6GMG0}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 348 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015298493. FT TRANSMEM 300 324 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 283 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 348 AA; 39358 MW; 23C271CFA16AE24D CRC64; MQSLIGLLLV VCLQYASGAT HSWKAYYTGT TGLTEFPEFV ALNLIDDQLM GYFDSKTNRF KSQFQWMEDN LGKEYDEQQT NILLGYPEVF KNNIKVVMER FNQTQGVHTF QFMYGCEMDD DGNKQVHWQI GYDGEDFISL DKKTLTWTAA NSQAMTTKVK WDSTGAEANY WKGYLENECI EWVQKYVGYG KDTLERKVSP QVSLLQKSSS SPVVCHVTGF YPSGLKISWQ RNGQDHDEDV ELGELIPNED GTYQRTSTLN VKPEEWKKDK FSCVVEHQSK TINSILTEDE IRTNNPTAPL GIIIGIVVAA VLLVAIAVAG FVVYRRHKGF KPVPQNTSDG GSDNSSRT // ID Q6MFY2_RAT Unreviewed; 330 AA. AC Q6MFY2; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 12-SEP-2018, entry version 136. DE SubName: Full=RT1 class I, M6, gene 1 {ECO:0000313|EMBL:CAE84065.1}; DE SubName: Full=RT1 class I, locus M6, gene 1 {ECO:0000313|Ensembl:ENSRNOP00000044917}; GN Name=RT1-M6-1 {ECO:0000313|Ensembl:ENSRNOP00000044917, GN ECO:0000313|RGD:1598232}; GN Synonyms=9430032L10Rik {ECO:0000313|RGD:1598232}, GN Gabbr1 {ECO:0000313|RGD:1598232}, Mog {ECO:0000313|RGD:1598232}, GN Olr1735_predicted {ECO:0000313|RGD:1598232}, GN Olr1736_predicted {ECO:0000313|RGD:1598232}, GN Olr1737_predicted {ECO:0000313|RGD:1598232}, GN Olr1738_predicted {ECO:0000313|RGD:1598232}, GN Olr1739_predicted {ECO:0000313|RGD:1598232}, GN Olr1742_predicted {ECO:0000313|RGD:1598232}, GN Olr1743_predicted {ECO:0000313|RGD:1598232}, GN Olr1744_predicted {ECO:0000313|RGD:1598232}, GN Olr1745_predicted {ECO:0000313|RGD:1598232}, GN Olr1746_predicted {ECO:0000313|RGD:1598232}, GN Olr1748_predicted {ECO:0000313|RGD:1598232}, GN Olr1749_predicted {ECO:0000313|RGD:1598232}, GN Olr1750_predicted {ECO:0000313|RGD:1598232}, GN Rps15-ps {ECO:0000313|RGD:1598232}, RT1-M3 {ECO:0000313|RGD:1598232}, GN RT1-M3-2 {ECO:0000313|RGD:1598232}, Ubd {ECO:0000313|RGD:1598232}, GN Zfp57 {ECO:0000313|RGD:1598232}, Znrd1 {ECO:0000313|RGD:1598232}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:CAE84065.1}; RN [1] {ECO:0000313|EMBL:CAE84065.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84065.1}; RA Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A., RA Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H., RA Sudbrak R., Reinhardt R.; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CAE84065.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84065.1}; RX PubMed=15060004; DOI=10.1101/gr.1987704; RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., RA Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.; RT "The genomic sequence and comparative analysis of the rat major RT histocompatibility complex."; RL Genome Res. 14:631-639(2004). RN [3] {ECO:0000313|Ensembl:ENSRNOP00000044917, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000044917, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [4] {ECO:0000313|Ensembl:ENSRNOP00000044917} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000044917}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC108572; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX883052; CAE84065.1; -; Genomic_DNA. DR RefSeq; NP_001008852.1; NM_001008852.1. DR UniGene; Rn.142703; -. DR Ensembl; ENSRNOT00000051480; ENSRNOP00000044917; ENSRNOG00000022107. DR GeneID; 414785; -. DR KEGG; rno:414785; -. DR UCSC; RGD:1598232; rat. DR CTD; 414785; -. DR RGD; 1598232; RT1-M6-1. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000022107; Expressed in 9 organ(s), highest expression level in testis. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 330 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015298571. FT TRANSMEM 287 311 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 193 281 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 330 AA; 36963 MW; D34F7CC4D741217E CRC64; MGAPVLHATL LLLSAFLALT QTKNQSFAGS HFMQYLVTTT SSQPGLQDSH VCIVGHVDYM PFMRFDSDGA AQRIQTRGPW MKQMGPEYLE MERKNAEGYS HRARENLRFA IQVYNQSDKA HYSHAFDGQH YISLNSDLTT WSVGDSTAQI TKRRWEADGV AEALSHFLKV SCVEHLQKHL ETGKETLQRS DPPKAHVTLH PRPEGDVTLR CWALGFYPAD ITLTWQLNGE DLTQDMELVE TRPAGDGTFQ KWASVVVPNG EEQKYTCLVE HEGLPEPLTL RWKPATWPVV GITVGVVLLG FVIIGALIAI VTMRKKRADP VDPVDLMDPV // ID Q6MFY3_RAT Unreviewed; 332 AA. AC Q6MFY3; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 12-SEP-2018, entry version 140. DE SubName: Full=RT1 class I, M6, gene 2 {ECO:0000313|EMBL:CAE84064.1}; DE SubName: Full=RT1 class I, locus M6, gene 2 {ECO:0000313|Ensembl:ENSRNOP00000048119}; GN Name=RT1-M6-2 {ECO:0000313|EMBL:CAE84064.1, GN ECO:0000313|Ensembl:ENSRNOP00000048119, ECO:0000313|RGD:1595815}; GN Synonyms=9430032L10Rik {ECO:0000313|RGD:1595815}, GN Gabbr1 {ECO:0000313|RGD:1595815}, Mog {ECO:0000313|RGD:1595815}, GN Olr1735_predicted {ECO:0000313|RGD:1595815}, GN Olr1736_predicted {ECO:0000313|RGD:1595815}, GN Olr1737_predicted {ECO:0000313|RGD:1595815}, GN Olr1738_predicted {ECO:0000313|RGD:1595815}, GN Olr1739_predicted {ECO:0000313|RGD:1595815}, GN Olr1742_predicted {ECO:0000313|RGD:1595815}, GN Olr1743_predicted {ECO:0000313|RGD:1595815}, GN Olr1744_predicted {ECO:0000313|RGD:1595815}, GN Olr1745_predicted {ECO:0000313|RGD:1595815}, GN Olr1746_predicted {ECO:0000313|RGD:1595815}, GN Olr1748_predicted {ECO:0000313|RGD:1595815}, GN Olr1749_predicted {ECO:0000313|RGD:1595815}, GN Olr1750_predicted {ECO:0000313|RGD:1595815}, GN Rps15-ps {ECO:0000313|RGD:1595815}, RT1-M3 {ECO:0000313|RGD:1595815}, GN RT1-M3-2 {ECO:0000313|RGD:1595815}, GN RT1-M6-1 {ECO:0000313|RGD:1595815}, Ubd {ECO:0000313|RGD:1595815}, GN Zfp57 {ECO:0000313|RGD:1595815}, Znrd1 {ECO:0000313|RGD:1595815}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:CAE84064.1}; RN [1] {ECO:0000313|EMBL:CAE84064.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84064.1}; RA Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A., RA Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H., RA Sudbrak R., Reinhardt R.; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CAE84064.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84064.1}; RX PubMed=15060004; DOI=10.1101/gr.1987704; RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., RA Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.; RT "The genomic sequence and comparative analysis of the rat major RT histocompatibility complex."; RL Genome Res. 14:631-639(2004). RN [3] {ECO:0000313|Ensembl:ENSRNOP00000048119, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000048119, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [4] {ECO:0000313|Ensembl:ENSRNOP00000048119} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000048119}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC108572; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX883052; CAE84064.1; -; Genomic_DNA. DR RefSeq; NP_001008853.1; NM_001008853.1. DR UniGene; Rn.163419; -. DR STRING; 10116.ENSRNOP00000048119; -. DR Ensembl; ENSRNOT00000041500; ENSRNOP00000048119; ENSRNOG00000040052. DR GeneID; 365527; -. DR KEGG; rno:365527; -. DR UCSC; RGD:1595815; rat. DR CTD; 365527; -. DR RGD; 1595815; RT1-M6-2. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; WDRNTRN; -. DR OrthoDB; EOG091G1F7P; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000040052; Expressed in 9 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 332 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015298580. FT TRANSMEM 289 313 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 193 283 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 332 AA; 37692 MW; 9E980EC82F7B294B CRC64; MGAPVLHATL LLLSAFLALT QTKNQSFAGS HSRQYLVTAT TSRPGLRDPH VFIVGYVDHM PFMRFDSDGV AQRIQARGPW VKQMGPEYLE MERKNAERYS HRARENLRFA IQVYNQSDKG HHRHAFDGQH YISLNSDLTT WSVADSTAQI TKRRWEADGV AEAFSHFLKV SCVEWLQKHL ETGKETLQRS DPPKTHVTHH PRPEGDATLR CWALDFYPAD ITLTWQEEEE EEELTQDMEL VETRPAGDGT FQKWASVVVP SGEEQKYTCH VYHEGLPEPL TLRWKPATWP VVGITVGVVL LGFVTIGALI AIVTMRKKRA DPVDPVDLMD PV // ID Q6MFZ8_RAT Unreviewed; 377 AA. AC Q6MFZ8; E9PSW1; L7N647; Q31279; R9Q796; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 12-SEP-2018, entry version 134. DE SubName: Full=RCG41803, isoform CRA_a {ECO:0000313|EMBL:EDL86699.1}; DE SubName: Full=RT1 class I, N2 {ECO:0000313|EMBL:CAE84049.1}; DE SubName: Full=RT1 class Ib, locus N2 {ECO:0000313|Ensembl:ENSRNOP00000049883}; GN Name=RT1-N2 {ECO:0000313|EMBL:CAE84049.1, GN ECO:0000313|Ensembl:ENSRNOP00000049883, ECO:0000313|RGD:1595850}; GN Synonyms=2310ex4-5 {ECO:0000313|RGD:1595850}, GN 2331ex4-5 {ECO:0000313|RGD:1595850}, GN 2361ex4-5 {ECO:0000313|RGD:1595850}, Flot1 {ECO:0000313|RGD:1595850}, GN Gnl1 {ECO:0000313|RGD:1595850}, Kiaa1949 {ECO:0000313|RGD:1595850}, GN Rpl41-ps {ECO:0000313|RGD:1595850}, GN Rps2-ps1 {ECO:0000313|RGD:1595850}, GN Rps2-ps2 {ECO:0000313|RGD:1595850}, RT1-O2 {ECO:0000313|RGD:1595850}, GN RT1-O3 {ECO:0000313|RGD:1595850}, RT1-S2 {ECO:0000313|RGD:1595850}, GN RT1-S3 {ECO:0000313|RGD:1595850}, RT1-T24-1 {ECO:0000313|RGD:1595850}, GN RT1-T24-2 {ECO:0000313|RGD:1595850}, Tubb5 {ECO:0000313|RGD:1595850}; GN ORFNames=rCG_41803 {ECO:0000313|EMBL:EDL86699.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:CAE84049.1}; RN [1] {ECO:0000313|EMBL:CAE84049.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84049.1}; RA Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A., RA Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H., RA Sudbrak R., Reinhardt R.; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CAE84049.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84049.1}; RX PubMed=15060004; DOI=10.1101/gr.1987704; RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., RA Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.; RT "The genomic sequence and comparative analysis of the rat major RT histocompatibility complex."; RL Genome Res. 14:631-639(2004). RN [3] {ECO:0000313|Ensembl:ENSRNOP00000049883, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000049883, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [4] {ECO:0000313|EMBL:EDL86699.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL86699.1}; RX PubMed=15632090; DOI=10.1101/gr.2889405; RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., RA Istrail S., Li P., Sutton G.; RT "Gene and alternative splicing annotation with AIR."; RL Genome Res. 15:54-66(2005). RN [5] {ECO:0000313|EMBL:EDL86699.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL86699.1}; RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., RA Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., RA Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|Ensembl:ENSRNOP00000049883} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000049883}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044362; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX883048; CAE84049.1; -; Genomic_DNA. DR EMBL; CH474118; EDL86699.1; -; Genomic_DNA. DR EMBL; CH474118; EDL86700.1; -; Genomic_DNA. DR EMBL; CH474118; EDL86701.1; -; Genomic_DNA. DR EMBL; CH474118; EDL86702.1; -; Genomic_DNA. DR RefSeq; NP_001008854.1; NM_001008854.2. DR RefSeq; XP_006256000.1; XM_006255938.3. DR UniGene; Rn.234331; -. DR STRING; 10116.ENSRNOP00000049883; -. DR PRIDE; Q6MFZ8; -. DR Ensembl; ENSRNOT00000050159; ENSRNOP00000049883; ENSRNOG00000029386. DR GeneID; 360323; -. DR KEGG; rno:360323; -. DR UCSC; RGD:1595850; rat. DR CTD; 360323; -. DR RGD; 1595850; RT1-N2. DR GeneTree; ENSGT00740000114936; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; AICICLK; -. DR OrthoDB; EOG0907079Q; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000029386; Expressed in 9 organ(s), highest expression level in colon. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 377 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015298562. FT DOMAIN 207 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 377 AA; 43290 MW; 802C9950EE175456 CRC64; MLWVPKAGAL WLSALLLLLN ASFSWTWTPE GSHSLRYFSI VMSWLGLREP RIIVSGCIDD TEFVRLDTNK EIVSLKPLVP LQEQEGLEYW EQQVHKVKTQ EQQSARNLMM LVRFYNKSMD DFHTLQWQQG CDVGSDGRLL HWYDQLAFDG VDHPTLNKDL RFWTAWTSTV AQISQPELEA RLKDNCSELL QKYPEKEKER LLRSDPPRAH VTRHPRPEGD VTLRCWALGF YPADITLTWQ LNGEDLIQEM EFVETRPAGD GTFQKWASVV VPLGKEQKYT CLVEHEGLSE PLTLRWEPTQ DSTTTIILII LPTVSAIVLC VAAAVAICIC LKKKAGERGR HDTRKQMETV PKTLAGLLWM IRRSRVPLGI LRTTELI // ID Q6MG01_RAT Unreviewed; 393 AA. AC Q6MG01; G5EBE1; H7C829; I1SB24; L7N646; Q31280; U3KRG4; V9HVV1; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 12-SEP-2018, entry version 134. DE SubName: Full=RT1 class I, N3 {ECO:0000313|EMBL:CAE84046.1}; DE SubName: Full=RT1 class Ib gene, H2-TL-like, grc region (N3) {ECO:0000313|EMBL:AAI58568.1}; DE SubName: Full=RT1 class Ib, locus N3 {ECO:0000313|Ensembl:ENSRNOP00000001035}; GN Name=RT1-N3 {ECO:0000313|EMBL:CAE84046.1, GN ECO:0000313|Ensembl:ENSRNOP00000001035, ECO:0000313|RGD:1598370}; GN Synonyms=2310ex4-5 {ECO:0000313|RGD:1598370}, GN 2331ex4-5 {ECO:0000313|RGD:1598370}, GN 2361ex4-5 {ECO:0000313|RGD:1598370}, Flot1 {ECO:0000313|RGD:1598370}, GN Gnl1 {ECO:0000313|RGD:1598370}, Kiaa1949 {ECO:0000313|RGD:1598370}, GN Rpl41-ps {ECO:0000313|RGD:1598370}, GN Rps2-ps1 {ECO:0000313|RGD:1598370}, GN Rps2-ps2 {ECO:0000313|RGD:1598370}, RT1-O2 {ECO:0000313|RGD:1598370}, GN RT1-O3 {ECO:0000313|RGD:1598370}, RT1-S2 {ECO:0000313|RGD:1598370}, GN RT1-S3 {ECO:0000313|RGD:1598370}, RT1-T24-1 {ECO:0000313|RGD:1598370}, GN RT1-T24-2 {ECO:0000313|RGD:1598370}, Tubb5 {ECO:0000313|RGD:1598370}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:CAE84046.1}; RN [1] {ECO:0000313|EMBL:CAE84046.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84046.1}; RA Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A., RA Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H., RA Sudbrak R., Reinhardt R.; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CAE84046.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84046.1}; RX PubMed=15060004; DOI=10.1101/gr.1987704; RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., RA Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.; RT "The genomic sequence and comparative analysis of the rat major RT histocompatibility complex."; RL Genome Res. 14:631-639(2004). RN [3] {ECO:0000313|EMBL:AAI58568.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Whole embryo {ECO:0000313|EMBL:AAI58568.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] {ECO:0000313|Ensembl:ENSRNOP00000001035, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000001035, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [5] {ECO:0000313|Ensembl:ENSRNOP00000001035} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000001035}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044362; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC158567; AAI58568.1; -; mRNA. DR EMBL; BX883048; CAE84046.1; -; Genomic_DNA. DR RefSeq; NP_001008855.1; NM_001008855.2. DR UniGene; Rn.202956; -. DR STRING; 10116.ENSRNOP00000001035; -. DR PRIDE; Q6MG01; -. DR Ensembl; ENSRNOT00000001035; ENSRNOP00000001035; ENSRNOG00000000795. DR GeneID; 24750; -. DR KEGG; rno:24750; -. DR UCSC; RGD:1598370; rat. DR CTD; 24750; -. DR RGD; 1598370; RT1-N3. DR GeneTree; ENSGT00740000114936; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; WIWIVAM; -. DR OrthoDB; EOG091G0M1Y; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000000795; Expressed in 9 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 89 109 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 393 AA; 45134 MW; 5F76C6D696B082B1 CRC64; MLWVPKAAAR WLSALLQILL LNACFSWTWT LVGSHSLRYF STVMSWPGLR EPRIIVSGYI DNMEFLRLDS DAETPRVKPL VPWLEQEGLE YLEQQIHRIR TQAQQSERNL MTLVRFYNKS MDDFHTLQWQ QGCDVGSDGR LLHWYDQLAF DGIDHPTLNK DLRFWTAWTS TVAQISQPEL EARLKDNCSE LLQKYPEKEK ERLLRSDPPR AHVTRHPRPE SDVTLRCWAL GFYPADITLT WQLNGEDLIQ EMEFVETRPA GDGTFQKWAS VVVPLGKEQK YTCLVEHEGL SEPLTLRWEP AQDSTTTIIL IILPTVSAIA LCVAAVATCI CLKKKAGERG RHDTQEADGD SPQDSSKIVV DDQEMEDPFW NTENYRTHLG YRSGTLGFLS LSP // ID Q6MG05_RAT Unreviewed; 330 AA. AC Q6MG05; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 12-SEP-2018, entry version 136. DE SubName: Full=RT1 class I, T24, gene 1 {ECO:0000313|EMBL:CAE84042.1}; DE SubName: Full=RT1 class I, locus T24, gene 1 {ECO:0000313|Ensembl:ENSRNOP00000050015}; GN Name=RT1-T24-1 {ECO:0000313|EMBL:CAE84042.1, GN ECO:0000313|Ensembl:ENSRNOP00000050015, ECO:0000313|RGD:1359499}; GN Synonyms=2310ex4-5 {ECO:0000313|RGD:1359499}, GN 2331ex4-5 {ECO:0000313|RGD:1359499}, GN 2361ex4-5 {ECO:0000313|RGD:1359499}, Flot1 {ECO:0000313|RGD:1359499}, GN Gnl1 {ECO:0000313|RGD:1359499}, Kiaa1949 {ECO:0000313|RGD:1359499}, GN Rpl41-ps {ECO:0000313|RGD:1359499}, GN Rps2-ps1 {ECO:0000313|RGD:1359499}, GN Rps2-ps2 {ECO:0000313|RGD:1359499}, RT1-O2 {ECO:0000313|RGD:1359499}, GN RT1-O3 {ECO:0000313|RGD:1359499}, RT1-S2 {ECO:0000313|RGD:1359499}, GN RT1-S3 {ECO:0000313|RGD:1359499}, RT1-T24-2 {ECO:0000313|RGD:1359499}, GN Tubb5 {ECO:0000313|RGD:1359499}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:CAE84042.1}; RN [1] {ECO:0000313|EMBL:CAE84042.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84042.1}; RA Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A., RA Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H., RA Sudbrak R., Reinhardt R.; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CAE84042.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84042.1}; RX PubMed=15060004; DOI=10.1101/gr.1987704; RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., RA Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.; RT "The genomic sequence and comparative analysis of the rat major RT histocompatibility complex."; RL Genome Res. 14:631-639(2004). RN [3] {ECO:0000313|Ensembl:ENSRNOP00000050015, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000050015, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [4] {ECO:0000313|Ensembl:ENSRNOP00000050015} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000050015}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044364; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX883048; CAE84042.1; -; Genomic_DNA. DR RefSeq; NP_001008858.1; NM_001008858.1. DR UniGene; Rn.215807; -. DR STRING; 10116.ENSRNOP00000050015; -. DR Ensembl; ENSRNOT00000041502; ENSRNOP00000050015; ENSRNOG00000032596. DR GeneID; 361787; -. DR KEGG; rno:361787; -. DR UCSC; RGD:1359499; rat. DR CTD; 361787; -. DR RGD; 1359499; RT1-T24-1. DR eggNOG; ENOG410J90V; Eukaryota. DR eggNOG; ENOG41117CA; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000032596; Expressed in 9 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT DOMAIN 210 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 330 AA; 38250 MW; 24AA2BFB0D970814 CRC64; MWSLIFCFLS HPQDTGARSH SLHYSYSAVT EPGPGVPAFF ASGFVDNQTF IHYDSRKMEA EPCADWLREN PYYFDEETQV FTNQMKIFQL SLRNIQQYYN SSGDRSHRAD GFHQQAGPHT LQFTYGCEMQ GNRTTGHWQY GYDGRDYLTL DLDSMQYTAA TFIAGYTKHK WQNNEYWLER EKTYLEKECV LWLKRYLTMG GENFTRTDPP QTTVTHHPRP EGDVTLRCWA LGFYPADITL TWQLNGEDLT QDMELVETRP TGDGTFQKWA AVVVPLGKEQ KYTCHVEHEG LPEPLTQRWE APPGTDSNMG INVIAVFFKL WPSLQLWPSS // ID Q6MG34_RAT Unreviewed; 360 AA. AC Q6MG34; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 12-SEP-2018, entry version 140. DE SubName: Full=RT1 class I, CE10 {ECO:0000313|EMBL:CAE84013.1}; DE SubName: Full=RT1 class I, locus CE10 {ECO:0000313|Ensembl:ENSRNOP00000069895}; GN Name=RT1-CE10 {ECO:0000313|EMBL:CAE84013.1, GN ECO:0000313|Ensembl:ENSRNOP00000069895, ECO:0000313|RGD:1359292}; GN Synonyms=Aif1 {ECO:0000313|RGD:1359292}, GN Cdk2ap1-ps2 {ECO:0000313|RGD:1359292}, GN Cdk2ap1-ps3 {ECO:0000313|RGD:1359292}, GN Cdk2ap1-ps4 {ECO:0000313|RGD:1359292}, GN Cdk2ap1-ps5 {ECO:0000313|RGD:1359292}, GN Cdk2ap1-ps6 {ECO:0000313|RGD:1359292}, GN E230034O05Rik {ECO:0000313|RGD:1359292}, GN LOC224733l-3 {ECO:0000313|RGD:1359292}, GN LOC224733l-4 {ECO:0000313|RGD:1359292}, GN LOC224733l-5 {ECO:0000313|RGD:1359292}, GN LOC224733l-6 {ECO:0000313|RGD:1359292}, GN LOC224733l-7 {ECO:0000313|RGD:1359292}, GN LOC224733l-8 {ECO:0000313|RGD:1359292}, GN Lst1 {ECO:0000313|RGD:1359292}, RT1-CE12 {ECO:0000313|RGD:1359292}, GN RT1-CE3 {ECO:0000313|RGD:1359292}, RT1-CE5 {ECO:0000313|RGD:1359292}, GN RT1-CE6 {ECO:0000313|RGD:1359292}, RT1-CE8 {ECO:0000313|RGD:1359292}, GN RT1-CE9 {ECO:0000313|RGD:1359292}, GN Sacm2l-ps3 {ECO:0000313|RGD:1359292}, GN Sacm2l-ps4 {ECO:0000313|RGD:1359292}, GN Sacm2l-ps5 {ECO:0000313|RGD:1359292}, GN Sacm2l-ps6 {ECO:0000313|RGD:1359292}, GN Sacm2l-ps7 {ECO:0000313|RGD:1359292}, Tnf {ECO:0000313|RGD:1359292}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:CAE84013.1}; RN [1] {ECO:0000313|EMBL:CAE84013.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84013.1}; RA Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A., RA Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H., RA Sudbrak R., Reinhardt R.; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CAE84013.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84013.1}; RA Shiina T., Inoko H.; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:CAE84013.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84013.1}; RX PubMed=15060004; DOI=10.1101/gr.1987704; RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., RA Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.; RT "The genomic sequence and comparative analysis of the rat major RT histocompatibility complex."; RL Genome Res. 14:631-639(2004). RN [4] {ECO:0000313|Ensembl:ENSRNOP00000069895, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000069895, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [5] {ECO:0000313|Ensembl:ENSRNOP00000069895} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000069895}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044242; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX883046; CAE84013.1; -; Genomic_DNA. DR RefSeq; NP_001008833.1; NM_001008833.1. DR RefSeq; XP_017457214.1; XM_017601725.1. DR RefSeq; XP_017457215.1; XM_017601726.1. DR UniGene; Rn.219012; -. DR STRING; 10116.ENSRNOP00000039057; -. DR PRIDE; Q6MG34; -. DR Ensembl; ENSRNOT00000084461; ENSRNOP00000069895; ENSRNOG00000050210. DR GeneID; 414792; -. DR KEGG; rno:414792; -. DR UCSC; RGD:1359292; rat. DR CTD; 414792; -. DR RGD; 1359292; RT1-CE10. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000050210; Expressed in 9 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q6MG34}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 360 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015298573. FT TRANSMEM 315 336 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 360 AA; 40904 MW; 88C31AB2AB516F75 CRC64; MEAMARPTLL LLLAAALAPT KTRAGSHWMR YFHTAVSRPG LGEPRYISVG YVDDTQFVRF DSDAENPRYE PRARWMEREG PEYWERNTRI VKGKEQIFRD NLRTLLGYYN QSEGGSHTLQ LMYGCDVGSD WSLLRGYEQH AYDGRDYIAL NEDLKTWAAA DFEAQKTRSK WEREGVAERS RAYLEGECVK WLRRHLEHGK EALLRLDPPE AHVTLHPRPE GDVTLRCWAL GFYPADITLT WQLNGEDLTQ DMEFVETRPA GDGTFQKWAS VVVPLGKEQN YTCLVEHEGL PEPLTQRWEP SPSTNTNMGI DVTSVFLGPL AVFVVLAIIG AAVAVVRRRR RRNTGGEGGD YTPAPGRDSS // ID Q6MG38_RAT Unreviewed; 352 AA. AC Q6MG38; F1LQG7; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 12-SEP-2018, entry version 131. DE SubName: Full=RT1 class I, CE3 {ECO:0000313|EMBL:CAE84009.1}; DE SubName: Full=RT1 class I, locus CE3 {ECO:0000313|Ensembl:ENSRNOP00000049460}; GN Name=RT1-CE3 {ECO:0000313|Ensembl:ENSRNOP00000049460, GN ECO:0000313|RGD:1598231}; GN Synonyms=Aif1 {ECO:0000313|RGD:1598231}, GN Cdk2ap1-ps2 {ECO:0000313|RGD:1598231}, GN Cdk2ap1-ps3 {ECO:0000313|RGD:1598231}, GN Cdk2ap1-ps4 {ECO:0000313|RGD:1598231}, GN Cdk2ap1-ps5 {ECO:0000313|RGD:1598231}, GN Cdk2ap1-ps6 {ECO:0000313|RGD:1598231}, GN E230034O05Rik {ECO:0000313|RGD:1598231}, GN LOC100365191 {ECO:0000313|RGD:1598231}, GN LOC224733l-3 {ECO:0000313|RGD:1598231}, GN LOC224733l-4 {ECO:0000313|RGD:1598231}, GN LOC224733l-5 {ECO:0000313|RGD:1598231}, GN LOC224733l-6 {ECO:0000313|RGD:1598231}, GN LOC224733l-7 {ECO:0000313|RGD:1598231}, GN LOC224733l-8 {ECO:0000313|RGD:1598231}, GN Lst1 {ECO:0000313|RGD:1598231}, RT1-CE12 {ECO:0000313|RGD:1598231}, GN RT1-CE5 {ECO:0000313|RGD:1598231}, RT1-CE6 {ECO:0000313|RGD:1598231}, GN RT1-CE8 {ECO:0000313|RGD:1598231}, RT1-CE9 {ECO:0000313|RGD:1598231}, GN Sacm2l-ps3 {ECO:0000313|RGD:1598231}, GN Sacm2l-ps4 {ECO:0000313|RGD:1598231}, GN Sacm2l-ps5 {ECO:0000313|RGD:1598231}, GN Sacm2l-ps6 {ECO:0000313|RGD:1598231}, GN Sacm2l-ps7 {ECO:0000313|RGD:1598231}, Tnf {ECO:0000313|RGD:1598231}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:CAE84009.1}; RN [1] {ECO:0000313|EMBL:CAE84009.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84009.1}; RA Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A., RA Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H., RA Sudbrak R., Reinhardt R.; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CAE84009.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84009.1}; RA Shiina T., Inoko H.; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:CAE84009.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84009.1}; RX PubMed=15060004; DOI=10.1101/gr.1987704; RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., RA Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.; RT "The genomic sequence and comparative analysis of the rat major RT histocompatibility complex."; RL Genome Res. 14:631-639(2004). RN [4] {ECO:0000313|Ensembl:ENSRNOP00000049460, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000049460, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [5] {ECO:0000313|Ensembl:ENSRNOP00000049460} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000049460}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044408; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX883046; CAE84009.1; -; Genomic_DNA. DR RefSeq; NP_001008841.1; NM_001008841.2. DR RefSeq; XP_017457222.1; XM_017601733.1. DR UniGene; Rn.40130; -. DR PRIDE; Q6MG38; -. DR Ensembl; ENSRNOT00000050099; ENSRNOP00000049460; ENSRNOG00000031607. DR GeneID; 414793; -. DR KEGG; rno:414793; -. DR CTD; 414793; -. DR RGD; 1598231; RT1-CE3. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; GINDRTE; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000031607; Expressed in 9 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 352 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015298565. FT TRANSMEM 312 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 352 AA; 39699 MW; 1490DCA5B05F7D10 CRC64; MEVMAPRALL LLLAAALALA QTGIGSHSLR YFETALSRPG FGESRFIIVG YVDDTQFMRF DSDAENPRME PRARWMEREG PGYWEQNTRM AKRQEQWYRV NLRTALRYYN QSEGGSHTFQ RMYGCDVGSD GSLLRGYNQF AYDSLDYIAL NEDLKTWTAA DTTGRMTQSK WVQAGVADYY RAYLEGECVE WLRRYLELGK ETLMRSDPPK AHVTLHPRPE GDVTLRCWAL GFYPADITLT WQLNGEDLTQ DMELVETRPA GDGTFQKWAS VVVPPGKEQN YTCLVEHEGL PEPLTLRWAP SLSTDSNMET TVIYVVLGAI SALAIIGALV PVVRRRKRNT GGKGGVYAPA PG // ID Q6MGB8_RAT Unreviewed; 366 AA. AC Q6MGB8; F7ERG5; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 12-SEP-2018, entry version 149. DE SubName: Full=RT1 class I, A2 {ECO:0000313|EMBL:CAE83928.1}; DE SubName: Full=RT1 class Ia, A2n {ECO:0000313|EMBL:AVP72126.1}; DE SubName: Full=RT1 class Ia, locus A2 {ECO:0000313|EMBL:AAH88465.1, ECO:0000313|Ensembl:ENSRNOP00000050701}; GN Name=RT1-A2 {ECO:0000313|EMBL:CAE83928.1, GN ECO:0000313|Ensembl:ENSRNOP00000050701, ECO:0000313|RGD:1595923}; GN Synonyms=AA926063 {ECO:0000313|RGD:1595923}, GN B3galt4 {ECO:0000313|RGD:1595923}, GN Cdk2ap1-ps1 {ECO:0000313|RGD:1595923}, GN Col11a2 {ECO:0000313|RGD:1595923}, Daxx {ECO:0000313|RGD:1595923}, GN Hsd17b8 {ECO:0000313|RGD:1595923}, Kifc1 {ECO:0000313|RGD:1595923}, GN LOC224733l-1 {ECO:0000313|RGD:1595923}, GN LOC224733l-2 {ECO:0000313|RGD:1595923}, GN Phf1 {ECO:0000313|RGD:1595923}, Rps25-ps1 {ECO:0000313|RGD:1595923}, GN RT1-A1 {ECO:0000313|RGD:1595923}, GN RT1-A2n {ECO:0000313|EMBL:AVP72126.1}, GN RT1-A3 {ECO:0000313|RGD:1595923}, RT1-DOa {ECO:0000313|RGD:1595923}, GN RT1-Hb {ECO:0000313|RGD:1595923}, RT1-Ke4 {ECO:0000313|RGD:1595923}, GN Rxrb {ECO:0000313|RGD:1595923}, Sacm2l-ps1 {ECO:0000313|RGD:1595923}, GN Sacm2l-ps2 {ECO:0000313|RGD:1595923}, GN Sec61-ps {ECO:0000313|RGD:1595923}, Syngap1 {ECO:0000313|RGD:1595923}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:CAE83928.1}; RN [1] {ECO:0000313|EMBL:CAE83928.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE83928.1}; RA Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A., RA Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H., RA Sudbrak R., Reinhardt R.; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CAE83928.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE83928.1}; RX PubMed=15060004; DOI=10.1101/gr.1987704; RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., RA Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.; RT "The genomic sequence and comparative analysis of the rat major RT histocompatibility complex."; RL Genome Res. 14:631-639(2004). RN [3] {ECO:0000313|EMBL:AAH88465.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney {ECO:0000313|EMBL:AAH88465.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] {ECO:0000313|Ensembl:ENSRNOP00000050701, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000050701, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [5] {ECO:0000313|Ensembl:ENSRNOP00000050701} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000050701}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [6] {ECO:0000313|EMBL:AVP72126.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=29531166; RA Dai K.Z., Ryan J.C., Naper C., Vaage J.T.; RT "Identification of MHC Class Ib Ligands for Stimulatory and Inhibitory RT Ly49 Receptors and Induction of Potent NK Cell Alloresponses in RT Rats."; RL J. Immunol. 200:2847-2859(2018). RN [7] {ECO:0000313|EMBL:AVP72126.1} RP NUCLEOTIDE SEQUENCE. RA Cohen D.B., Kent A.D.; RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044422; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC088465; AAH88465.1; -; mRNA. DR EMBL; MG963096; AVP72126.1; -; mRNA. DR EMBL; BX883042; CAE83928.1; -; Genomic_DNA. DR RefSeq; NP_001008829.1; NM_001008829.1. DR UniGene; Rn.116787; -. DR IntAct; Q6MGB8; 1. DR STRING; 10116.ENSRNOP00000050701; -. DR Ensembl; ENSRNOT00000052270; ENSRNOP00000050701; ENSRNOG00000030712. DR GeneID; 24974; -. DR KEGG; rno:24974; -. DR CTD; 24974; -. DR RGD; 1595923; RT1-A2. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000030712; Expressed in 9 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q6MGB8}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015098372. FT TRANSMEM 310 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 41393 MW; 92AD4D9EF21F1974 CRC64; MMEPCTLLLL LAVALTPTQT RAGSHSLRYF VTAVSRPGLG EPRYMEVGYV DDTQFVRYDS DAENPRYEPR APWMEREGPE YWERETQNAK RNEQVYRVDL RTALRYYNQS EGGSHTIQRM YGCDMGSDGS LLRGYYQDAY DGRDYIALNE DLKTWTAADF AAQITRSKWD QAGVAERLRA YLEGTCVEWL RRYLELGKET LLRSDPPEAH VTLHPRPEGD VTLRCWALGF YPADITLTWQ LNGEDLTQDM ELVETRPAGD GTFQKWASVV VPLGKEQNYT CRVEHEGLPE PLSQRWEPSP STNSNMETTV IYVVLGAIIG TLAIIGIVVA VVRKRRRNTG GKGDYTPAPG RDSSQSSDVS LPDCKA // ID Q6MGB9_RAT Unreviewed; 369 AA. AC Q6MGB9; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 12-SEP-2018, entry version 130. DE SubName: Full=RT1 class I, A1 {ECO:0000313|EMBL:CAE83927.1}; DE SubName: Full=RT1 class Ia, locus A1 {ECO:0000313|Ensembl:ENSRNOP00000075633}; GN Name=RT1-A1 {ECO:0000313|Ensembl:ENSRNOP00000075633, GN ECO:0000313|RGD:1595924}; GN Synonyms=AA926063 {ECO:0000313|RGD:1595924}, GN B3galt4 {ECO:0000313|RGD:1595924}, GN Cdk2ap1-ps1 {ECO:0000313|RGD:1595924}, GN Col11a2 {ECO:0000313|RGD:1595924}, Daxx {ECO:0000313|RGD:1595924}, GN Hsd17b8 {ECO:0000313|RGD:1595924}, Kifc1 {ECO:0000313|RGD:1595924}, GN LOC224733l-1 {ECO:0000313|RGD:1595924}, GN LOC224733l-2 {ECO:0000313|RGD:1595924}, GN Phf1 {ECO:0000313|RGD:1595924}, Rps25-ps1 {ECO:0000313|RGD:1595924}, GN RT1-A2 {ECO:0000313|RGD:1595924}, RT1-A3 {ECO:0000313|RGD:1595924}, GN RT1-DOa {ECO:0000313|RGD:1595924}, RT1-Hb {ECO:0000313|RGD:1595924}, GN RT1-Ke4 {ECO:0000313|RGD:1595924}, Rxrb {ECO:0000313|RGD:1595924}, GN Sacm2l-ps1 {ECO:0000313|RGD:1595924}, GN Sacm2l-ps2 {ECO:0000313|RGD:1595924}, GN Sec61-ps {ECO:0000313|RGD:1595924}, Syngap1 {ECO:0000313|RGD:1595924}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:CAE83927.1}; RN [1] {ECO:0000313|EMBL:CAE83927.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE83927.1}; RA Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A., RA Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H., RA Sudbrak R., Reinhardt R.; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CAE83927.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE83927.1}; RX PubMed=15060004; DOI=10.1101/gr.1987704; RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., RA Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.; RT "The genomic sequence and comparative analysis of the rat major RT histocompatibility complex."; RL Genome Res. 14:631-639(2004). RN [3] {ECO:0000313|Ensembl:ENSRNOP00000075633, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000075633, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [4] {ECO:0000313|Ensembl:ENSRNOP00000075633} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000075633}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044421; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044422; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044423; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044424; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX883042; CAE83927.1; -; Genomic_DNA. DR RefSeq; NP_001008827.1; NM_001008827.1. DR UniGene; Rn.233151; -. DR STRING; 10116.ENSRNOP00000039088; -. DR PRIDE; Q6MGB9; -. DR Ensembl; ENSRNOT00000078972; ENSRNOP00000075633; ENSRNOG00000038999. DR GeneID; 24973; -. DR KEGG; rno:24973; -. DR UCSC; RGD:1595924; rat. DR CTD; 24973; -. DR RGD; 1595924; RT1-A1. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000038999; Expressed in 9 organ(s), highest expression level in adult mammalian kidney. DR Genevisible; Q6MGB9; RN. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0030881; F:beta-2-microglobulin binding; IPI:RGD. DR GO; GO:0042277; F:peptide binding; IDA:RGD. DR GO; GO:0046982; F:protein heterodimerization activity; IPI:RGD. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0045953; P:negative regulation of natural killer cell mediated cytotoxicity; IMP:RGD. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:RGD. DR GO; GO:0002657; P:positive regulation of tolerance induction to nonself antigen; IMP:RGD. DR GO; GO:0002517; P:T cell tolerance induction; IMP:RGD. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q6MGB9}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 369 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015298570. FT TRANSMEM 312 335 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 369 AA; 41498 MW; 3F0AD1741F62543F CRC64; MGAMAPRTLL LILAAALAPT QTRAGSHSMR YFDIAVSRPG LGEPRFIIVG YVDDTEFVRF DSDAEKPRYE PRAPWMEPEG PEYWEEQTRR AKEGEQTFRV NLRTALHYYN QSEDRSHTIQ RLSGCDVGSD GRLLRGYEQY AYDGRDYIAL NEDLKTWTAA DFAARISRNK WDQAGVAERL RAYLEGECVE WLRRYLELGK ETLLRSDPPK AHVTLHPRPE GDVTLRCWAL GFYPADITLT WQLNGEDLTQ DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCRVEHEGL PEPLSQRWEP PPSTDSNMET TVIYVVLGAV AIIAAVIIGA VVTVVRKRRR NTGGKGVYTP APGTDSSQSS DVSLPDCKA // ID Q6PKB0_MOUSE Unreviewed; 369 AA. AC Q6PKB0; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 12-SEP-2018, entry version 107. DE SubName: Full=Fcgrt protein {ECO:0000313|EMBL:AAH03786.1}; DE SubName: Full=IgG receptor FcRn large subunit p51 {ECO:0000313|Ensembl:ENSMUSP00000147496}; GN Name=Fcgrt {ECO:0000313|EMBL:AAH03786.1, GN ECO:0000313|Ensembl:ENSMUSP00000147496, ECO:0000313|MGI:MGI:103017}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH03786.1}; RN [1] {ECO:0000313|EMBL:AAH03786.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Mix FVB/N {ECO:0000313|EMBL:AAH03786.1}; RC TISSUE=Mammary tumor. WAP-TGF alpha model. 7 months old RC {ECO:0000313|EMBL:AAH03786.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000147496, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000147496, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000147496} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000147496}; RG Ensembl; RL Submitted (JUL-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC126256; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC003786; AAH03786.1; -; mRNA. DR RefSeq; XP_006540666.1; XM_006540603.1. DR UniGene; Mm.3303; -. DR Ensembl; ENSMUST00000210642; ENSMUSP00000147496; ENSMUSG00000003420. DR GeneID; 14132; -. DR UCSC; uc009gte.2; mouse. DR CTD; 2217; -. DR MGI; MGI:103017; Fcgrt. DR eggNOG; ENOG410IPRY; Eukaryota. DR eggNOG; ENOG4111C4R; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000112560; -. DR HOVERGEN; HBG100415; -. DR OMA; PWISLRG; -. DR Proteomes; UP000000589; Chromosome 7. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:Q6PKB0, KW ECO:0000213|MaxQB:Q6PKB0, ECO:0000213|PeptideAtlas:Q6PKB0}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 369 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015098444. FT TRANSMEM 304 325 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 206 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 369 AA; 40562 MW; B4F99CA9D6EB9AFC CRC64; MGMPLPWALS LLLVLLPQTW GSETRPPLMY HLTAVSNPST GLPSFWATGW LGPQQYLTYN SLRQEADPCG AWMWENQVSW YWEKETTDLK SKEQLFLEAL KTLEKILNGQ KRGTYTLQGL LGCELASDNS SVPTAVFALN GEEFMKFNPR IGNWTGEWPE TEIVANLWMK QPDAARKESE FLLNSCPERL LGHLERGRRN LEWKEPPSMR LKARPGNSGS SVLTCAAFSF YPPELKFRFL RNGLASGSGN CSTGPNGDGS FHAWSLLEVK RGDEHHYQCQ VEHEGLAQPL TVDLDSSARS SVPVVGIVLG LLLVVVAIAG GVLLWGRMRS GLPAPWLSLS GDDSGDLLPG GNLPPEAEPQ GANAFPATS // ID Q6W9J5_RAT Unreviewed; 344 AA. AC Q6W9J5; F1LW75; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 12-SEP-2018, entry version 124. DE SubName: Full=MHC class Ib antigen {ECO:0000313|EMBL:AAQ81309.1}; DE SubName: Full=RT1 class Ib, locus M2 {ECO:0000313|Ensembl:ENSRNOP00000043659}; GN Name=RT1-M2 {ECO:0000313|EMBL:AAQ81309.1, GN ECO:0000313|Ensembl:ENSRNOP00000043659, ECO:0000313|RGD:3493}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAQ81309.1}; RN [1] {ECO:0000313|EMBL:AAQ81309.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=F344 {ECO:0000313|EMBL:AAQ81309.1}; RX PubMed=15045471; DOI=10.1007/s00251-004-0661-6; RA Moore Y.F., Lambracht-Washington D., Tabaczewski P., RA Fischer Lindahl K.; RT "Murine MHC class Ib gene, H2-M2, encodes a conserved surface- RT expressed glycoprotein."; RL Immunogenetics 56:1-11(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000043659, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000043659, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [3] {ECO:0000313|Ensembl:ENSRNOP00000043659} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000043659}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044291; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AY302218; AAQ81309.1; -; Genomic_DNA. DR RefSeq; NP_001001717.1; NM_001001717.1. DR STRING; 10116.ENSRNOP00000043659; -. DR PRIDE; Q6W9J5; -. DR Ensembl; ENSRNOT00000041074; ENSRNOP00000043659; ENSRNOG00000049590. DR GeneID; 24988; -. DR KEGG; rno:24988; -. DR CTD; 24988; -. DR RGD; 3493; RT1-M2. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; RITQRFY; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000049590; Expressed in 6 organ(s), highest expression level in spleen. DR GO; GO:0009986; C:cell surface; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 344 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015298794. FT TRANSMEM 305 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 344 AA; 39293 MW; FC195716A73781C4 CRC64; METSAILTLH LLLSASLALT QSFKGSHSLR YFDIAVSRPG LEETHYMTLG YVDDTEFVHF NNEAVNPRFE PRVPWMEQMG QKYWDDQTRI AKVAEQQIRV YFQKLRGYYN QSQNSSHTIQ RMTGCYIGPD GHLLHAYRQF GYDGQDYLTL NEDLSTWTAA DSAAEITHRE WKATNEAEFW RVYLEGPCMV WLFKYLTVGN ETLLRADPPK VYVTHHPRPE GDITLRCWAL GFYPSDITLI WQRDGEDLTQ DMDVIETRPA GDGTFQKWAA VVVPSGKEQN YTCYVEHEGL PEPLTLRWSR PPQSFIPTIV VAVGLVLLGA SVVTLVIWKK SSGGGRGSLR FLSN // ID Q6W9J6_MOUSE Unreviewed; 304 AA. AC Q6W9J6; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 12-SEP-2018, entry version 128. DE SubName: Full=Histocompatibility 2, M region locus 2 {ECO:0000313|Ensembl:ENSMUSP00000016427}; DE SubName: Full=MHC class Ib antigen {ECO:0000313|EMBL:AAQ81308.1}; GN Name=H2-M2 {ECO:0000313|Ensembl:ENSMUSP00000016427, GN ECO:0000313|MGI:MGI:95914}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAQ81308.1}; RN [1] {ECO:0000313|EMBL:AAQ81308.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/10SnJ {ECO:0000313|EMBL:AAQ81308.1}; RX PubMed=15045471; DOI=10.1007/s00251-004-0661-6; RA Moore Y.F., Lambracht-Washington D., Tabaczewski P., RA Fischer Lindahl K.; RT "Murine MHC class Ib gene, H2-M2, encodes a conserved surface- RT expressed glycoprotein."; RL Immunogenetics 56:1-11(2004). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000016427, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000016427, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000016427} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000016427}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR974427; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AY302217; AAQ81308.1; -; mRNA. DR RefSeq; NP_032230.1; NM_008204.2. DR UniGene; Mm.329041; -. DR STRING; 10090.ENSMUSP00000016427; -. DR Ensembl; ENSMUST00000016427; ENSMUSP00000016427; ENSMUSG00000016283. DR GeneID; 14990; -. DR UCSC; uc008cmz.1; mouse. DR CTD; 14990; -. DR MGI; MGI:95914; H2-M2. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000016283; Expressed in 28 organ(s), highest expression level in thymus. DR GO; GO:0009986; C:cell surface; IDA:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q6W9J6}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 304 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015098576. FT DOMAIN 213 301 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 304 AA; 35296 MW; 677ABE37DADD795A CRC64; METSAFFTLL FTLYLLLGAS LALAQTFKGS HSLRYFDIAV SRPGLEETHY MTVGYVDDTE FVHFDNEAEN PRFEPRVPWM EQMGQKYWDD QTRIAKAAEQ QIRVYFQKLR DYYNQSQNSS HTIQRMTGCY IGPDGHLLHA YRQFGYDGQD YLTLNEDLST WTAADAAAEI TRREWEATNV AEFWRVYLEG PCMVWLFKYL TVGNETLLRT EPPKAYVTHH PRPEGDVTLR CWALGFYPSD IIMIWQRDGE DQTQDMDVIE TRPAGDGTFQ KWVAVVVPSG KEQNYTCHVA HEGLPEPLTL RWSK // ID Q6W9L1_MOUSE Unreviewed; 343 AA. AC Q6W9L1; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 12-SEP-2018, entry version 143. DE SubName: Full=Histocompatibility 2, M region locus 2 {ECO:0000313|Ensembl:ENSMUSP00000131297}; DE SubName: Full=MHC class Ib antigen {ECO:0000313|EMBL:AAQ82664.1}; GN Name=H2-M2 {ECO:0000313|EMBL:AAQ82664.1, GN ECO:0000313|Ensembl:ENSMUSP00000131297, ECO:0000313|MGI:MGI:95914}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAQ82664.1}; RN [1] {ECO:0000313|EMBL:AAQ82664.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=129/SvJ {ECO:0000313|EMBL:AAQ82664.1}, RC C3H/HeJ {ECO:0000313|EMBL:AAQ82665.1}, RC C57BL/10SnJ {ECO:0000313|EMBL:AAQ81303.1}, and RC LP-RIII/J {ECO:0000313|EMBL:AAQ82667.1}; RC TISSUE=Thymus {ECO:0000313|EMBL:AAQ81303.1}; RX PubMed=15045471; DOI=10.1007/s00251-004-0661-6; RA Moore Y.F., Lambracht-Washington D., Tabaczewski P., RA Fischer Lindahl K.; RT "Murine MHC class Ib gene, H2-M2, encodes a conserved surface- RT expressed glycoprotein."; RL Immunogenetics 56:1-11(2004). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000131297, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000131297, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000131297} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000131297}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR974427; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AY302212; AAQ81303.1; -; mRNA. DR EMBL; AY302213; AAQ81304.1; -; mRNA. DR EMBL; AH013247; AAQ82663.1; -; Genomic_DNA. DR EMBL; AY302188; AAQ82663.1; JOINED; Genomic_DNA. DR EMBL; AH013248; AAQ82664.1; -; Genomic_DNA. DR EMBL; AY302189; AAQ82664.1; JOINED; Genomic_DNA. DR EMBL; AH013249; AAQ82665.1; -; Genomic_DNA. DR EMBL; AY302190; AAQ82665.1; JOINED; Genomic_DNA. DR EMBL; AH013251; AAQ82667.1; -; Genomic_DNA. DR RefSeq; NP_001334316.1; NM_001347387.1. DR UniGene; Mm.329041; -. DR Ensembl; ENSMUST00000171139; ENSMUSP00000131297; ENSMUSG00000016283. DR GeneID; 14990; -. DR KEGG; mmu:14990; -. DR UCSC; uc008cna.1; mouse. DR CTD; 14990; -. DR MGI; MGI:95914; H2-M2. DR GeneTree; ENSGT00760000118960; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; RITQRFY; -. DR OrthoDB; EOG091G09OH; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000016283; Expressed in 28 organ(s), highest expression level in thymus. DR GO; GO:0009986; C:cell surface; IDA:MGI. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q6W9L1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 343 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015098577. FT TRANSMEM 309 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 213 301 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 343 AA; 39348 MW; E84B46ACF1AE4BBC CRC64; METSAFFTLL FTLYLLLGAS LALAQTFKGS HSLRYFDIAV SRPGLEETHY MTVGYVDDTE FVHFDNEAEN PRFEPRVPWM EQMGQKYWDD QTRIAKAAEQ QIRVYFQKLR DYYNQSQNSS HTIQRMTGCY IGPDGHLLHA YRQFGYDGQD YLTLNEDLST WTAADAAAEI TRREWEATNV AEFWRVYLEG PCMVWLFKYL TVGNETLLRT EPPKAYVTHH PRPEGDVTLR CWALGFYPSD IIMIWQRDGE DQTQDMDVIE TRPAGDGTFQ KWVAVVVPSG KEQNYTCHVA HEGLPEPLTL RWSRPPQSFI FIIIVAVGLV LLGASVATLV MWKKSSGGER GSL // ID Q7YP14_DANRE Unreviewed; 326 AA. AC Q7YP14; A0A286YBE2; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 01-OCT-2003, sequence version 1. DT 12-SEP-2018, entry version 110. DE SubName: Full=Major histocompatibility complex class I ZEA {ECO:0000313|Ensembl:ENSDARP00000144516}; DE SubName: Full=SI:dZ63M10.3 (Novel MHC class I antigen) {ECO:0000313|EMBL:CAE30374.1}; GN Name=mhc1zea {ECO:0000313|Ensembl:ENSDARP00000144516, GN ECO:0000313|ZFIN:ZDB-GENE-070705-176}; GN Synonyms=SI:dZ63M10.3 {ECO:0000313|EMBL:CAE30374.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:CAE30374.1}; RN [1] {ECO:0000313|EMBL:CAE30374.1} RP NUCLEOTIDE SEQUENCE. RA Corby N.; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSDARP00000144516, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000144516, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [3] {ECO:0000313|Ensembl:ENSDARP00000144516} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000144516}; RG Ensembl; RL Submitted (OCT-2017) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX005416; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL672016; CAE30374.1; -; Genomic_DNA. DR RefSeq; NP_001039028.1; NM_001045563.1. DR UniGene; Dr.77541; -. DR Ensembl; ENSDART00000176803; ENSDARP00000144516; ENSDARG00000001470. DR GeneID; 565708; -. DR KEGG; dre:565708; -. DR CTD; 565708; -. DR ZFIN; ZDB-GENE-070705-176; mhc1zea. DR GeneTree; ENSGT00740000114936; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000000437; Chromosome 1. DR Bgee; ENSDARG00000001470; Expressed in 16 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 326 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015299080. FT DOMAIN 212 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 326 AA; 38196 MW; B034657007AC5649 CRC64; MAVFAALFSV VMLFTVVPAW TEKHSLYYIY TALSRPVHLP GIYEFTAMGL LDDRQIDYYN SQEQKKIPKQ HWMKEKMQED YWEKGTQSRK SKEQWFNVNL KILMERMRHN NNSDVHVLQW RHGCEIDSQG NDVRFSKGID EYSYDGRNFL AFDDADSQWV APVEEALPTK RKWDNVPILN QYTKGYLEKE CVDWLNKFRE YGDQELREGS PPDVHVFAKK IISGKAKLKL TCMVTGFYPK DVILTIRKYR TALSDNEVES SGVRPNPDGT FQLRKSTNIY EKAEYDCYVA HRTLKEPIIK KWGNQSIQKK HLVKMGSART ALQELP // ID Q85ZW5_MOUSE Unreviewed; 330 AA. AC Q85ZW5; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 12-SEP-2018, entry version 142. DE SubName: Full=Histocompatibility 2, M region locus 10.6 {ECO:0000313|EMBL:AAO50325.1, ECO:0000313|Ensembl:ENSMUSP00000039908}; DE SubName: Full=Major histocompatibility complex class Ib M10.8 {ECO:0000313|EMBL:AAO42750.1}; GN Name=H2-M10.6 {ECO:0000313|Ensembl:ENSMUSP00000039908, GN ECO:0000313|MGI:MGI:2687364}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAO42750.1}; RN [1] {ECO:0000313|EMBL:AAO42750.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAO42750.1}; RX PubMed=12628182; DOI=10.1016/S0092-8674(03)00153-3; RA Loconto J., Papes F., Chang E., Stowers L., Jones E.P., Takada T., RA Kumanovics A., Fischer Lindahl K., Dulac C.; RT "Functional expression of murine V2R pheromone receptors involves RT selective association with the M10 and M1 families of MHC class Ib RT molecules."; RL Cell 112:607-618(2003). RN [2] {ECO:0000313|EMBL:AAO50325.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAO50325.1}; RC TISSUE=Vomeronasal organ {ECO:0000313|EMBL:AAO50325.1}; RX PubMed=12620187; DOI=10.1016/S0960-9822(03)00092-7; RA Ishii T., Hirota J., Mombaerts P.; RT "Combinatorial coexpression of neural and immune multigene families in RT mouse vomeronasal sensory neurons."; RL Curr. Biol. 13:394-400(2003). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000039908, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000039908, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000039908} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000039908}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC154819; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AY211083; AAO42750.1; -; mRNA. DR EMBL; AF539602; AAO50325.1; -; mRNA. DR RefSeq; NP_963905.1; NM_201611.2. DR RefSeq; XP_011244825.1; XM_011246523.1. DR UniGene; Mm.329034; -. DR STRING; 10090.ENSMUSP00000039908; -. DR DNASU; 399549; -. DR Ensembl; ENSMUST00000041398; ENSMUSP00000039908; ENSMUSG00000037130. DR GeneID; 399549; -. DR KEGG; mmu:399549; -. DR UCSC; uc008clf.2; mouse. DR CTD; 399549; -. DR MGI; MGI:2687364; H2-M10.6. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; TESWIAP; -. DR OrthoDB; EOG091G1EJF; -. DR TreeFam; TF336617; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000037130; Expressed in 4 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 330 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015099004. FT TRANSMEM 305 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 330 AA; 37598 MW; 8E2CC0A7658A8E98 CRC64; MRKPGPWDLL LLLMAIDLTQ YCAGSHWLQI FNIVILEPGM LEARFIQVGY VDSIQFQGFD SKEPNARMQP RAAWMKQEPP EYWEKETAKA LSFSLSGRRI LKYMMSANKD KNNGYHTLQE VYGCNVANDG SFLEGHYRLT YYGYDSLILN EDLNSWTAEG EVGEKFKTYQ EQGGMTESWR TYLLGECVER LLRCLDLGKK TLLHSDAPRT HVTHHVRPEG NVTLRCWALG FYPADITMTW KRDGKNHTQD MELPDTRPAG DGTFQKWAAV VVPPGEELRY TCHVNHEGLP GPLTLKWEPP HTIPIIAILI GLVLGALVVG TVVIFLVWKN // ID Q85ZW6_MOUSE Unreviewed; 330 AA. AC Q85ZW6; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 12-SEP-2018, entry version 145. DE SubName: Full=Histocompatibility 2, M region locus 10.3 {ECO:0000313|EMBL:AAO50322.1, ECO:0000313|Ensembl:ENSMUSP00000073236}; DE SubName: Full=Major histocompatibility complex class Ib M10.3 {ECO:0000313|EMBL:AAO42747.1}; GN Name=H2-M10.3 {ECO:0000313|Ensembl:ENSMUSP00000073236, GN ECO:0000313|MGI:MGI:1276524}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAO42747.1}; RN [1] {ECO:0000313|EMBL:AAO42747.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAO42747.1}; RX PubMed=12628182; DOI=10.1016/S0092-8674(03)00153-3; RA Loconto J., Papes F., Chang E., Stowers L., Jones E.P., Takada T., RA Kumanovics A., Fischer Lindahl K., Dulac C.; RT "Functional expression of murine V2R pheromone receptors involves RT selective association with the M10 and M1 families of MHC class Ib RT molecules."; RL Cell 112:607-618(2003). RN [2] {ECO:0000313|EMBL:AAO50322.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAO50322.1}; RC TISSUE=Vomeronasal organ {ECO:0000313|EMBL:AAO50322.1}; RX PubMed=12620187; DOI=10.1016/S0960-9822(03)00092-7; RA Ishii T., Hirota J., Mombaerts P.; RT "Combinatorial coexpression of neural and immune multigene families in RT mouse vomeronasal sensory neurons."; RL Curr. Biol. 13:394-400(2003). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000073236, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000073236, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000073236} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000073236}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC120403; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AY211080; AAO42747.1; -; mRNA. DR EMBL; AF539599; AAO50322.1; -; mRNA. DR RefSeq; NP_963902.1; NM_201608.2. DR UniGene; Mm.303091; -. DR STRING; 10090.ENSMUSP00000073236; -. DR DNASU; 110696; -. DR Ensembl; ENSMUST00000073546; ENSMUSP00000073236; ENSMUSG00000058124. DR GeneID; 110696; -. DR KEGG; mmu:110696; -. DR UCSC; uc008ckz.1; mouse. DR CTD; 110696; -. DR MGI; MGI:1276524; H2-M10.3. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; NIAFLEP; -. DR OrthoDB; EOG090B089C; -. DR TreeFam; TF336617; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000058124; Expressed in 7 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 330 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015098989. FT TRANSMEM 305 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 330 AA; 38331 MW; 878B55AA6DD3947B CRC64; MRNPGCCTLL LLLVAMDLNQ YCAGSHWLQT FNIAFLEPGM INSRFIHIGY VDSIQYQGFD SKEPMAILKP RAAWMEQELP KYWNVETTKI LLLSQIERRI LYFMIEKYEH RMNDYHTLQE VYGCNVATDG RFLHGHFRLT YYGYDYLTLN EDLSSWTAEG KGAEYMKNRW ENMSEAERWK TYLRGECVQR LLRYLDLGKE TLLRSDAPRT HVTHHVRPEG NVTLRCWALG FYPADITLTW KRDGNNLTQD MELPDTRPAG DGTFQKWAAV VVPSGEELRY TCHVHHEGLP EPLTLKWEPP QTIPIIAILI GLVLGTLVVG TVVIFLVWKK // ID Q85ZW7_MOUSE Unreviewed; 330 AA. AC Q85ZW7; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 12-SEP-2018, entry version 142. DE SubName: Full=Histocompatibility 2, M region locus 10.5 {ECO:0000313|EMBL:AAO50324.1, ECO:0000313|Ensembl:ENSMUSP00000047766}; GN Name=H2-M10.5 {ECO:0000313|Ensembl:ENSMUSP00000047766, GN ECO:0000313|MGI:MGI:1276526}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAO50324.1}; RN [1] {ECO:0000313|EMBL:AAO50324.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAO50324.1}; RC TISSUE=Vomeronasal organ {ECO:0000313|EMBL:AAO50324.1}; RX PubMed=12620187; DOI=10.1016/S0960-9822(03)00092-7; RA Ishii T., Hirota J., Mombaerts P.; RT "Combinatorial coexpression of neural and immune multigene families in RT mouse vomeronasal sensory neurons."; RL Curr. Biol. 13:394-400(2003). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000047766, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000047766, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000047766} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000047766}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC154819; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AF539601; AAO50324.1; -; mRNA. DR RefSeq; NP_808305.2; NM_177637.3. DR UniGene; Mm.246584; -. DR STRING; 10090.ENSMUSP00000047766; -. DR DNASU; 224761; -. DR Ensembl; ENSMUST00000041531; ENSMUSP00000047766; ENSMUSG00000037246. DR GeneID; 224761; -. DR KEGG; mmu:224761; -. DR UCSC; uc008cle.1; mouse. DR CTD; 224761; -. DR MGI; MGI:1276526; H2-M10.5. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OrthoDB; EOG090B089C; -. DR TreeFam; TF336617; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000037246; Expressed in 1 organ(s), highest expression level in thymus. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 330 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015098985. FT TRANSMEM 303 328 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 330 AA; 37762 MW; 8D2F1B11E8C26E0C CRC64; MRNPGCCTLL LLLVAMDLIQ YCAGSHWLQT FNAVILEPGM VNSRFVHIGY VDSIEYQRYD SKEPIAVLLP RVAWMEQVPM TYWTSETASV AELSQLDRRI LHFMVNKNEQ RMDDYHTLQE VYGCNVANDG SFLGGHFRLT YYGYDDLYLN ENLSSWIAHG NAAEYVKSRW DGEGDAERWK TYLQGVCVER LLRYMVLGKE ALLRSDAPRT HVTHHVRPEG NVTLRCWALG FYPADITMTW KRDGNNHTQD MELPDTRPAG DGTFQKWAAV VVPSGEELRY TCHVHHKGLP EPLKLKWEPP HTIPIIAILI GLVLGTLVVG TVVIFLVWKK // ID Q85ZW8_MOUSE Unreviewed; 331 AA. AC Q85ZW8; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 12-SEP-2018, entry version 141. DE SubName: Full=Histocompatibility 2, M region locus 10.4 {ECO:0000313|EMBL:AAO50323.1, ECO:0000313|Ensembl:ENSMUSP00000058686}; DE SubName: Full=MCG141184 {ECO:0000313|EMBL:EDL23295.1}; GN Name=H2-M10.4 {ECO:0000313|Ensembl:ENSMUSP00000058686, GN ECO:0000313|MGI:MGI:1276527}; GN ORFNames=mCG_141184 {ECO:0000313|EMBL:EDL23295.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAO50323.1}; RN [1] {ECO:0000313|EMBL:EDL23295.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL23295.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [2] {ECO:0000313|EMBL:AAO50323.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAO50323.1}; RC TISSUE=Vomeronasal organ {ECO:0000313|EMBL:AAO50323.1}; RX PubMed=12620187; DOI=10.1016/S0960-9822(03)00092-7; RA Ishii T., Hirota J., Mombaerts P.; RT "Combinatorial coexpression of neural and immune multigene families in RT mouse vomeronasal sensory neurons."; RL Curr. Biol. 13:394-400(2003). RN [3] {ECO:0000313|EMBL:EDL23295.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL23295.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSMUSP00000058686, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000058686, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [5] {ECO:0000313|Ensembl:ENSMUSP00000058686} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000058686}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC120403; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AF539600; AAO50323.1; -; mRNA. DR EMBL; CH466559; EDL23295.1; -; Genomic_DNA. DR RefSeq; NP_808302.1; NM_177634.1. DR RefSeq; XP_006524186.1; XM_006524123.1. DR UniGene; Mm.246581; -. DR STRING; 10090.ENSMUSP00000058686; -. DR DNASU; 224753; -. DR Ensembl; ENSMUST00000057502; ENSMUSP00000058686; ENSMUSG00000048231. DR Ensembl; ENSMUST00000169950; ENSMUSP00000130832; ENSMUSG00000048231. DR GeneID; 224753; -. DR KEGG; mmu:224753; -. DR UCSC; uc008cla.1; mouse. DR CTD; 224753; -. DR MGI; MGI:1276527; H2-M10.4. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OrthoDB; EOG090B089C; -. DR TreeFam; TF336617; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000048231; Expressed in 3 organ(s), highest expression level in embryonic stem cell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 331 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015098996. FT TRANSMEM 306 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 331 AA; 37657 MW; E12CAA38C6ED4033 CRC64; MRNPGHFAIL CLLLVTIDRP QYCEGSHWLK TFRIVIMEPG ILEPRFIQVS YVDSIQYQGF DSRSETAGMQ PRAAWMKQEP PEYWKNETEH AMGASLLARR TLIYMVTENN NKKNDYHTLQ EVFGCNVAHD GSFLGGHYGL TYYGYDYIIL NEDLNSWTTE GKVGGKFNPD RTQGSVTEGW RTYLKGECTE RFLRCLDLGK ETLLRSDAPR THVTHKVTPE GNVTLRCWAL GFYPADITLT WKRDGKNHTQ DMELPDTRPA GDGTFQKWAA VVVPFGEELR YTCHVHHEGL PGPLTLKWGP PQTIPIIAIL IGLVLVALVV GTVVIFLVWR K // ID Q85ZW9_MOUSE Unreviewed; 329 AA. AC Q85ZW9; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 12-SEP-2018, entry version 144. DE SubName: Full=Histocompatibility 2, M region locus 10.2 {ECO:0000313|EMBL:AAO50321.1, ECO:0000313|Ensembl:ENSMUSP00000023845}; GN Name=H2-M10.2 {ECO:0000313|EMBL:AAI37986.1, GN ECO:0000313|Ensembl:ENSMUSP00000023845, ECO:0000313|MGI:MGI:1276525}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAO50321.1}; RN [1] {ECO:0000313|EMBL:AAO50321.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAO50321.1}; RC TISSUE=Vomeronasal organ {ECO:0000313|EMBL:AAO50321.1}; RX PubMed=12620187; DOI=10.1016/S0960-9822(03)00092-7; RA Ishii T., Hirota J., Mombaerts P.; RT "Combinatorial coexpression of neural and immune multigene families in RT mouse vomeronasal sensory neurons."; RL Curr. Biol. 13:394-400(2003). RN [2] {ECO:0000313|EMBL:AAI37986.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain {ECO:0000313|EMBL:AAI37986.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000023845, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000023845, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000023845} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000023845}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC129554; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC137985; AAI37986.1; -; mRNA. DR EMBL; BC137987; AAI37988.1; -; mRNA. DR EMBL; AF539598; AAO50321.1; -; mRNA. DR RefSeq; NP_808591.1; NM_177923.1. DR UniGene; Mm.246798; -. DR STRING; 10090.ENSMUSP00000023845; -. DR Ensembl; ENSMUST00000023845; ENSMUSP00000023845; ENSMUSG00000023083. DR GeneID; 333715; -. DR KEGG; mmu:333715; -. DR UCSC; uc008ckx.1; mouse. DR CTD; 333715; -. DR MGI; MGI:1276525; H2-M10.2. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OrthoDB; EOG090B089C; -. DR TreeFam; TF336617; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000023083; Expressed in 15 organ(s), highest expression level in bone marrow. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 329 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015098995. FT TRANSMEM 304 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 329 AA; 37517 MW; B70DB5CAA34E422E CRC64; MNPGPCNFLL LLVALDLTQY CAGSHWLQTF NTVILKHGTL EPRIIQVGYV DSIQYQGFDS KEPTARMQPR AAWMEQEPPE YWEKETAQVL RLSLTNERLL RYMMIYNEQS NEEYHTLQEV FGCNVDNDGS FLGGLYRLTY YGYEFINLNE DLSSWTAQGE AAGFLKTDLV NVGAAEGWRT YLLGECTERL LRCLDLGKET LLRSDAPRTH VTHHVRPEGN VTLRCWALGF YPADITLTWK RDGKNYTQDM ELPDTRPAGD GTFQKWAAVV VPSGEELRYT CHVHHEGLPE PLTLKWEPPQ TIPIIAILIG LVLGTFLVGT VVVFLVWKK // ID Q861Q1_RAT Unreviewed; 373 AA. AC Q861Q1; E9PT10; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 12-SEP-2018, entry version 145. DE SubName: Full=MHC class I protein {ECO:0000313|EMBL:CAC85698.1}; DE SubName: Full=RT1 class I, CE4 {ECO:0000313|EMBL:CAE84010.1}; DE SubName: Full=RT1 class I, locus CE4 {ECO:0000313|Ensembl:ENSRNOP00000047044}; GN Name=RT1-CE4 {ECO:0000313|EMBL:CAE84010.1, GN ECO:0000313|Ensembl:ENSRNOP00000047044, ECO:0000313|RGD:1598234}; GN Synonyms=Aif1 {ECO:0000313|RGD:1598234}, GN Cdk2ap1-ps2 {ECO:0000313|RGD:1598234}, GN Cdk2ap1-ps3 {ECO:0000313|RGD:1598234}, GN Cdk2ap1-ps4 {ECO:0000313|RGD:1598234}, GN Cdk2ap1-ps5 {ECO:0000313|RGD:1598234}, GN Cdk2ap1-ps6 {ECO:0000313|RGD:1598234}, GN E230034O05Rik {ECO:0000313|RGD:1598234}, GN LOC224733l-3 {ECO:0000313|RGD:1598234}, GN LOC224733l-4 {ECO:0000313|RGD:1598234}, GN LOC224733l-5 {ECO:0000313|RGD:1598234}, GN LOC224733l-6 {ECO:0000313|RGD:1598234}, GN LOC224733l-7 {ECO:0000313|RGD:1598234}, GN LOC224733l-8 {ECO:0000313|RGD:1598234}, GN Lst1 {ECO:0000313|RGD:1598234}, GN RT1-C/E4 {ECO:0000313|EMBL:CAC85698.1}, GN RT1-CE12 {ECO:0000313|RGD:1598234}, RT1-CE3 {ECO:0000313|RGD:1598234}, GN RT1-CE5 {ECO:0000313|RGD:1598234}, RT1-CE6 {ECO:0000313|RGD:1598234}, GN RT1-CE8 {ECO:0000313|RGD:1598234}, RT1-CE9 {ECO:0000313|RGD:1598234}, GN Sacm2l-ps3 {ECO:0000313|RGD:1598234}, GN Sacm2l-ps4 {ECO:0000313|RGD:1598234}, GN Sacm2l-ps5 {ECO:0000313|RGD:1598234}, GN Sacm2l-ps6 {ECO:0000313|RGD:1598234}, GN Sacm2l-ps7 {ECO:0000313|RGD:1598234}, Tnf {ECO:0000313|RGD:1598234}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:CAC85698.1}; RN [1] {ECO:0000313|EMBL:CAC85698.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:CAC85698.1}; RA Walter L.; RT "Sequence analysis of the rat MHC class I region."; RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CAE84010.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84010.1}; RA Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A., RA Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H., RA Sudbrak R., Reinhardt R.; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:CAE84010.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84010.1}; RA Shiina T., Inoko H.; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:CAE84010.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84010.1}; RX PubMed=15060004; DOI=10.1101/gr.1987704; RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., RA Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.; RT "The genomic sequence and comparative analysis of the rat major RT histocompatibility complex."; RL Genome Res. 14:631-639(2004). RN [5] {ECO:0000313|Ensembl:ENSRNOP00000047044, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000047044, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [6] {ECO:0000313|Ensembl:ENSRNOP00000047044} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000047044}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044397; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044398; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044399; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044400; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044401; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044402; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044403; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044404; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044405; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07044406; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJ314857; CAC85698.1; -; Genomic_DNA. DR EMBL; BX883046; CAE84010.1; -; Genomic_DNA. DR RefSeq; NP_001008842.1; NM_001008842.1. DR UniGene; Rn.215620; -. DR STRING; 10116.ENSRNOP00000059471; -. DR Ensembl; ENSRNOT00000041151; ENSRNOP00000047044; ENSRNOG00000039744. DR GeneID; 414783; -. DR KEGG; rno:414783; -. DR UCSC; RGD:1598234; rat. DR CTD; 414783; -. DR RGD; 1598234; RT1-CE4. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR TreeFam; TF336617; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000039744; Expressed in 9 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 373 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015299175. FT TRANSMEM 312 336 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 373 AA; 42082 MW; 999C56A7BA8F4B6A CRC64; MGAMAPPTLL LLVAAALTPT KTRAGSHSLR YFHTAVSRPG LGEPRFISVG YVDDTEFVRY DSDAENPRYE PRARWMEREG PEYWERQTQI AKRNEQVYRV DLSTLRGYYN QSEGGSHTYQ RMHGCELGSD GSLLRGYMQY AYDGRDYIAL NEDLKTWMVK DTAARITRNK WDQAGFGERK RTYLQVECLE WLRKYLELGK ETLLRSDPPK VHVTLHPRPE GGVTLRCWAL GFYPADITLT WQLNGEDLTQ DMELVETRPA GDGTFQKWAA VVVPSGEEQK YTCHVEHEGL PEPLTQRWEA PPGTDSNMET NVIYVFFGAV AMIGAVAVIG AVVAVVRRRR RRKRNTGGKG DYAPAPGSDS CQSSDVSLAD CEA // ID Q8HWA1_MOUSE Unreviewed; 244 AA. AC Q8HWA1; DT 01-MAR-2003, integrated into UniProtKB/TrEMBL. DT 01-MAR-2003, sequence version 1. DT 12-SEP-2018, entry version 116. DE SubName: Full=Histocompatibility 2, M region locus 9 {ECO:0000313|Ensembl:ENSMUSP00000084409}; GN Name=H2-M9 {ECO:0000313|Ensembl:ENSMUSP00000084409, GN ECO:0000313|MGI:MGI:1276570}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC37860.1}; RN [1] {ECO:0000313|EMBL:BAC37860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37860.1}; RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAC37860.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAC37860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37860.1}; RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAC37860.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAC37860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37860.1}; RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAC37860.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAC37860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37860.1}; RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAC37860.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAC37860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37860.1}; RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAC37860.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [6] {ECO:0000313|EMBL:BAC37860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37860.1}; RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAC37860.1}; RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., RA Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., RA Hori F., Imotani K., Ishii Y., Itoh M., Kagawa I., Kasukawa T., RA Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., RA Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., RA Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., RA Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., RA Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., RA Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., RA Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:BAC37860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37860.1}; RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAC37860.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] {ECO:0000313|EMBL:BAC37860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37860.1}; RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAC37860.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [9] {ECO:0000313|Ensembl:ENSMUSP00000084409, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000084409, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [10] {ECO:0000313|Ensembl:ENSMUSP00000084409} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000084409}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC126245; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AK080256; BAC37860.1; -; mRNA. DR UniGene; Mm.57004; -. DR Ensembl; ENSMUST00000087165; ENSMUSP00000084409; ENSMUSG00000067201. DR UCSC; uc012asw.1; mouse. DR MGI; MGI:1276570; H2-M9. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000067201; Expressed in 89 organ(s), highest expression level in mammary gland. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 244 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015099151. FT TRANSMEM 215 238 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 25 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 244 AA; 28421 MW; 0E7E93C15DCB8334 CRC64; MKNFESQPLL LLFMVTLVIA KHPNGSHTLR FVSTFLSWPR HLELQFIFLI YVDETQIMGF NSISESQRME SRVPWLNELN AEFWELATQD VLKEKSFVTG IMNKLLHIYN DSMTGYHIIQ ETYGCQVKQR TYFSHAFMEL LFDTHDYITL NEDLQTWRAV GKAAEIVKEE WEKINLVKSS KSFLLGACVE GLLQYLNFGK KYLLRTDPPE PTIPFLPMII ALVLGALLMG SVMTFLIWKR RTRG // ID Q8HWB2_MOUSE Unreviewed; 354 AA. AC Q8HWB2; DT 01-MAR-2003, integrated into UniProtKB/TrEMBL. DT 01-MAR-2003, sequence version 1. DT 12-SEP-2018, entry version 157. DE SubName: Full=Histocompatibility 2, Q region locus 4 {ECO:0000313|Ensembl:ENSMUSP00000080159}; GN Name=H2-Q4 {ECO:0000313|Ensembl:ENSMUSP00000080159, GN ECO:0000313|MGI:MGI:95933}; GN Synonyms=H2-Gs10 {ECO:0000313|MGI:MGI:95933}, GN H2-gs10 {ECO:0000313|MGI:MGI:95933}, GN H2-Q1 {ECO:0000313|MGI:MGI:95933}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC29831.1}; RN [1] {ECO:0000313|EMBL:BAC29831.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC29831.1}; RC TISSUE=Thymus {ECO:0000313|EMBL:BAC29831.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAC29831.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC29831.1}; RC TISSUE=Thymus {ECO:0000313|EMBL:BAC29831.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAC29831.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC29831.1}; RC TISSUE=Thymus {ECO:0000313|EMBL:BAC29831.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAC29831.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC29831.1}; RC TISSUE=Thymus {ECO:0000313|EMBL:BAC29831.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAC29831.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC29831.1}; RC TISSUE=Thymus {ECO:0000313|EMBL:BAC29831.1}; RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., RA Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., RA Hori F., Imotani K., Ishii Y., Itoh M., Kagawa I., Kasukawa T., RA Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., RA Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., RA Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., RA Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., RA Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., RA Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., RA Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:BAC29831.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC29831.1}; RC TISSUE=Thymus {ECO:0000313|EMBL:BAC29831.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [7] {ECO:0000313|EMBL:BAC29831.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC29831.1}; RC TISSUE=Thymus {ECO:0000313|EMBL:BAC29831.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] {ECO:0000313|EMBL:BAC29831.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC29831.1}; RC TISSUE=Thymus {ECO:0000313|EMBL:BAC29831.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [9] {ECO:0000313|Ensembl:ENSMUSP00000080159, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000080159, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [10] {ECO:0000313|Ensembl:ENSMUSP00000080159} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000080159}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR974466; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AK037574; BAC29831.1; -; mRNA. DR RefSeq; NP_001137161.1; NM_001143689.1. DR UniGene; Mm.464284; -. DR STRING; 10090.ENSMUSP00000080159; -. DR Ensembl; ENSMUST00000081435; ENSMUSP00000080159; ENSMUSG00000035929. DR GeneID; 15015; -. DR KEGG; mmu:15015; -. DR UCSC; uc008chm.2; mouse. DR CTD; 15015; -. DR MGI; MGI:95933; H2-Q4. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; VTHHPVF; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000035929; Expressed in 20 organ(s), highest expression level in spleen. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; ISO:MGI. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI. DR GO; GO:0042605; F:peptide antigen binding; ISO:MGI. DR GO; GO:0042277; F:peptide binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0042608; F:T cell receptor binding; ISO:MGI. DR GO; GO:0046977; F:TAP binding; ISO:MGI. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Proteomics identification {ECO:0000213|EPD:Q8HWB2, KW ECO:0000213|MaxQB:Q8HWB2, ECO:0000213|PeptideAtlas:Q8HWB2}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 354 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015099160. FT DOMAIN 234 322 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 354 AA; 39618 MW; 7A85FDE240D19656 CRC64; MASTMLLLLV AVAQTLIEIR AAPRPAPLPA RSPAGGPGRS SGSHRALPPG PHLLSYFYTS VSRPGLGEPR FISVGYVDNT EFVRFDSDAE NPRYEPRAPW MEQEGPEYWE RETQKAKGNE QIFRVNLRTL LSYYNQSAGG SHTIQVISGC EVGSDGRLLR GYQQFAYDGR DYIALNEDLK TWTAADMAAQ ITRRKWEQAG ATEKSKAYLE GACVQSLRRY LELGKETLLR TDPPKAHVTC HHRSDGDVTL RCWALGFYPA NIILTWQLNG EELTQDMELV ETRPSGDGTF QKWASVVVPL GKEQNYTCHV HHEGLPEPLT LRWEPPPSTV SNMANVAVLV VLGAWPSLQL WWLL // ID Q8HWE5_MOUSE Unreviewed; 355 AA. AC Q8HWE5; DT 01-MAR-2003, integrated into UniProtKB/TrEMBL. DT 01-MAR-2003, sequence version 1. DT 12-SEP-2018, entry version 126. DE SubName: Full=MHC I-like leukocyte 2 {ECO:0000313|EMBL:AAI44887.1, ECO:0000313|Ensembl:ENSMUSP00000072223}; DE SubName: Full=MHC I-like leukocyte 2 long form {ECO:0000313|EMBL:BAC21671.1}; GN Name=Mill2 {ECO:0000313|EMBL:BAC21671.1, GN ECO:0000313|Ensembl:ENSMUSP00000072223, ECO:0000313|MGI:MGI:2179989}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC21671.1}; RN [1] {ECO:0000313|EMBL:BAC21671.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BALB/c {ECO:0000313|EMBL:BAC21671.1}; RX PubMed=12370446; DOI=10.1073/pnas.212375299; RA Kasahara M., Watanabe Y., Sumasu M., Nagata T.; RT "A family of MHC class I-like genes located in the vicinity of the RT mouse leukocyte receptor complex."; RL Proc. Natl. Acad. Sci. U.S.A. 99:13687-13692(2002). RN [2] {ECO:0000313|EMBL:AAI44887.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain {ECO:0000313|EMBL:AAI44887.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000072223, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000072223, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000072223} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000072223}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [5] {ECO:0000313|Ensembl:ENSMUSP00000154268} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000154268}; RG Ensembl; RL Submitted (JAN-2018) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC153651; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC144886; AAI44887.1; -; mRNA. DR EMBL; AB086267; BAC21671.1; -; mRNA. DR RefSeq; NP_715642.2; NM_153761.3. DR RefSeq; XP_006539995.1; XM_006539932.3. DR RefSeq; XP_017177723.1; XM_017322234.1. DR UniGene; Mm.233503; -. DR STRING; 10090.ENSMUSP00000072223; -. DR Ensembl; ENSMUST00000072386; ENSMUSP00000072223; ENSMUSG00000040987. DR Ensembl; ENSMUST00000228493; ENSMUSP00000154268; ENSMUSG00000040987. DR GeneID; 243864; -. DR UCSC; uc009fjt.1; mouse. DR CTD; 243864; -. DR MGI; MGI:2179989; Mill2. DR eggNOG; ENOG410J8UC; Eukaryota. DR eggNOG; ENOG4111ECF; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000148357; -. DR HOVERGEN; HBG060058; -. DR OMA; LVLQSHW; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF339076; -. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000000589; Chromosome 7. DR Bgee; ENSMUSG00000040987; Expressed in 20 organ(s), highest expression level in lung. DR GO; GO:0031362; C:anchored component of external side of plasma membrane; IDA:MGI. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; ISO:MGI. DR GO; GO:0046629; P:gamma-delta T cell activation; ISO:MGI. DR GO; GO:0002429; P:immune response-activating cell surface receptor signaling pathway; ISO:MGI. DR GO; GO:0050689; P:negative regulation of defense response to virus by host; ISO:MGI. DR GO; GO:0009408; P:response to heat; ISO:MGI. DR GO; GO:0006979; P:response to oxidative stress; ISO:MGI. DR GO; GO:0032526; P:response to retinoic acid; ISO:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Proteomics identification {ECO:0000213|MaxQB:Q8HWE5}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 355 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015099155. FT DOMAIN 231 321 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 355 AA; 39224 MW; B52D0EEA0871C2C5 CRC64; MKASSGKPRE FRPAVLLLIL GLLLRDSRGS SIQGFLADVE VHGSSRLTRT HTLRYNVRAH SLEGSEKTQL LVLIYVDEEL FLKYNGDSRE TEPLGCWIKG HGGNETCARE TNNLLKVEEK LRGMMAEVIN QKSQEEGLHT LQATLGCELL SNGSTRGFWH LGYDGQNFLT FDQKTLTWTV DGPSTQQNKM FWKTHAPRAD LVKTFLDDIC PAHLQRYLAS LRNGLQDTGP PMVTVTCRNY PVGRVTLTCR AFNLYTREAT LVWLQDGKPV QQKTFRSETI LPSGDGTYQA RVSIRVLPGQ EPQFSCNLRH GNHSIMQTAV SGHAAEDSQD VASSATASAG SALPVVLAVA LARAN // ID Q8HWE6_MOUSE Unreviewed; 340 AA. AC Q8HWE6; DT 01-MAR-2003, integrated into UniProtKB/TrEMBL. DT 01-MAR-2003, sequence version 1. DT 12-SEP-2018, entry version 130. DE SubName: Full=MHC I-like leukocyte 2 {ECO:0000313|EMBL:AAI37749.1, ECO:0000313|Ensembl:ENSMUSP00000072246}; DE SubName: Full=MHC I-like leukocyte 2 short form {ECO:0000313|EMBL:BAC21670.1}; GN Name=Mill2 {ECO:0000313|EMBL:BAC21670.1, GN ECO:0000313|Ensembl:ENSMUSP00000072246, ECO:0000313|MGI:MGI:2179989}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC21670.1}; RN [1] {ECO:0000313|EMBL:BAC21670.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BALB/c {ECO:0000313|EMBL:BAC21670.1}; RX PubMed=12370446; DOI=10.1073/pnas.212375299; RA Kasahara M., Watanabe Y., Sumasu M., Nagata T.; RT "A family of MHC class I-like genes located in the vicinity of the RT mouse leukocyte receptor complex."; RL Proc. Natl. Acad. Sci. U.S.A. 99:13687-13692(2002). RN [2] {ECO:0000313|EMBL:AAI37749.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain {ECO:0000313|EMBL:AAI37749.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000072246, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000072246, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000072246} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000072246}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [5] {ECO:0000313|Ensembl:ENSMUSP00000154222} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000154222}; RG Ensembl; RL Submitted (JAN-2018) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC153651; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC137748; AAI37749.1; -; mRNA. DR EMBL; AB086266; BAC21670.1; -; mRNA. DR RefSeq; NP_715641.1; NM_153760.2. DR RefSeq; XP_006539996.1; XM_006539933.3. DR UniGene; Mm.233503; -. DR Ensembl; ENSMUST00000072415; ENSMUSP00000072246; ENSMUSG00000040987. DR Ensembl; ENSMUST00000227379; ENSMUSP00000154222; ENSMUSG00000040987. DR GeneID; 243864; -. DR KEGG; mmu:243864; -. DR UCSC; uc009fju.1; mouse. DR CTD; 243864; -. DR MGI; MGI:2179989; Mill2. DR eggNOG; ENOG410J8UC; Eukaryota. DR eggNOG; ENOG4111ECF; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000148357; -. DR HOVERGEN; HBG060058; -. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000000589; Chromosome 7. DR Bgee; ENSMUSG00000040987; Expressed in 20 organ(s), highest expression level in lung. DR GO; GO:0031362; C:anchored component of external side of plasma membrane; IDA:MGI. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; ISO:MGI. DR GO; GO:0046629; P:gamma-delta T cell activation; ISO:MGI. DR GO; GO:0002429; P:immune response-activating cell surface receptor signaling pathway; ISO:MGI. DR GO; GO:0050689; P:negative regulation of defense response to virus by host; ISO:MGI. DR GO; GO:0009408; P:response to heat; ISO:MGI. DR GO; GO:0006979; P:response to oxidative stress; ISO:MGI. DR GO; GO:0032526; P:response to retinoic acid; ISO:MGI. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Proteomics identification {ECO:0000213|MaxQB:Q8HWE6}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 340 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015099144. FT DOMAIN 216 306 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 340 AA; 37556 MW; 190C9A8FB7E460DF CRC64; MKASSGKPRE FRPAVLLLIL GLLLRDSRGS SIQGTHTLRY NVRAHSLEGS EKTQLLVLIY VDEELFLKYN GDSRETEPLG CWIKGHGGNE TCARETNNLL KVEEKLRGMM AEVINQKSQE EGLHTLQATL GCELLSNGST RGFWHLGYDG QNFLTFDQKT LTWTVDGPST QQNKMFWKTH APRADLVKTF LDDICPAHLQ RYLASLRNGL QDTGPPMVTV TCRNYPVGRV TLTCRAFNLY TREATLVWLQ DGKPVQQKTF RSETILPSGD GTYQARVSIR VLPGQEPQFS CNLRHGNHSI MQTAVSGHAA EDSQDVASSA TASAGSALPV VLAVALARAN // ID Q8HWE7_MOUSE Unreviewed; 395 AA. AC Q8HWE7; DT 01-MAR-2003, integrated into UniProtKB/TrEMBL. DT 01-MAR-2003, sequence version 1. DT 12-SEP-2018, entry version 128. DE SubName: Full=MCG58238 {ECO:0000313|EMBL:EDL23077.1}; DE SubName: Full=MHC I-like leukocyte 1 {ECO:0000313|EMBL:AAI10548.1, ECO:0000313|EMBL:BAC21669.1, ECO:0000313|Ensembl:ENSMUSP00000069083}; GN Name=Mill1 {ECO:0000313|EMBL:BAC21669.1, GN ECO:0000313|Ensembl:ENSMUSP00000069083, ECO:0000313|MGI:MGI:2179988}; GN ORFNames=mCG_58238 {ECO:0000313|EMBL:EDL23077.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC21669.1}; RN [1] {ECO:0000313|EMBL:BAC21669.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BALB/c {ECO:0000313|EMBL:BAC21669.1}; RC TISSUE=Skin {ECO:0000313|EMBL:BAC21669.1}; RX PubMed=12370446; DOI=10.1073/pnas.212375299; RA Kasahara M., Watanabe Y., Sumasu M., Nagata T.; RT "A family of MHC class I-like genes located in the vicinity of the RT mouse leukocyte receptor complex."; RL Proc. Natl. Acad. Sci. U.S.A. 99:13687-13692(2002). RN [2] {ECO:0000313|EMBL:EDL23077.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL23077.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [3] {ECO:0000313|EMBL:AAI10548.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI10548.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] {ECO:0000313|EMBL:EDL23077.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL23077.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|Ensembl:ENSMUSP00000069083, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000069083, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [6] {ECO:0000313|Ensembl:ENSMUSP00000069083} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000069083}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC151983; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC110547; AAI10548.1; -; mRNA. DR EMBL; BC110548; AAI10549.1; -; mRNA. DR EMBL; AB086265; BAC21669.1; -; mRNA. DR EMBL; CH466639; EDL23077.1; -; Genomic_DNA. DR RefSeq; NP_715630.3; NM_153749.4. DR UniGene; Mm.106769; -. DR Ensembl; ENSMUST00000066780; ENSMUSP00000069083; ENSMUSG00000054005. DR GeneID; 266815; -. DR KEGG; mmu:266815; -. DR UCSC; uc009fjh.1; mouse. DR CTD; 266815; -. DR MGI; MGI:2179988; Mill1. DR eggNOG; ENOG410J8UC; Eukaryota. DR eggNOG; ENOG4111ECF; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOVERGEN; HBG060058; -. DR OMA; VIVTFRN; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF339076; -. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Proteomes; UP000000589; Chromosome 7. DR Bgee; ENSMUSG00000054005; Expressed in 7 organ(s), highest expression level in zone of skin. DR GO; GO:0031362; C:anchored component of external side of plasma membrane; IDA:MGI. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 32 {ECO:0000256|SAM:SignalP}. FT CHAIN 33 395 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015099152. FT DOMAIN 242 333 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 122 145 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 395 AA; 44745 MW; FA076D1DB7060364 CRC64; MLLSRNLRAL AAIHLWIVYL LLEDLLGTCA EGDNQRLVAS APYQDIEITL EKPRVQAVAE PHTLRYDLMA LSLEVPGLPQ FLTLRYFDDE PFLPYKKNSS ITDSQEPRIK DHLRAETWGR ETDDLQEEEE QLKGMLAEIT AQNGQNTDLH ILQATFGCEL QRNGSTRGFW KLGYDGQNFL TFDQKTLTWT VDGPSTQKNK TFWKTRAPRA DLVKTFLDDI CPAQLQRYLA SLRNGLLNTG FPKVIVTFRN YPVGRITLTC RAFRLYTRVA TLTWLQYRKP VQQKTFGSET ILPSGDGTYQ AWVSIRVLPG QESQFSCNLK HGNHNINEPA ATEAPVYGAR REQPPTSGVG SRVGKSLWSA MTTALVVISW TLSQKLMGPL LWFCSGGFCS FLQCW // ID Q8MH48_HUMAN Unreviewed; 338 AA. AC Q8MH48; DT 01-OCT-2002, integrated into UniProtKB/TrEMBL. DT 01-OCT-2002, sequence version 1. DT 18-JUL-2018, entry version 115. DE SubName: Full=HLA class I histocompatibility antigen, alpha chain G {ECO:0000313|Ensembl:ENSP00000479303}; DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:ADN34679.1}; DE SubName: Full=MHC class Ib antigen {ECO:0000313|EMBL:AAM74997.1}; GN Name=HLA-G {ECO:0000313|EMBL:AAM74997.1, GN ECO:0000313|Ensembl:ENSP00000479303}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAM74997.1}; RN [1] {ECO:0000313|Ensembl:ENSP00000479303, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|EMBL:AAM74997.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16570139; DOI=10.1007/s00251-005-0076-z; RA Pyo C.W., Williams L.M., Moore Y., Hyodo H., Li S.S., Zhao L.P., RA Sageshima N., Ishitani A., Geraghty D.E.; RT "HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines RT haplotype structure and variation spanning the nonclassical class I RT genes."; RL Immunogenetics 58:241-251(2006). RN [3] {ECO:0000313|EMBL:ADN34679.1} RP NUCLEOTIDE SEQUENCE. RA Martinez Laso J., Cervera Hernandez I.; RT "Evolution of MHC-G Alleles."; RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSP00000479303} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. RN [5] {ECO:0000313|EMBL:AUW30193.1} RP NUCLEOTIDE SEQUENCE. RA Di Cristofaro J., Ribeyre C.; RT "HLA-G haplotypes are differentially associated with asthmatic RT features."; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR925767; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AF523303; AAM74997.1; -; Genomic_DNA. DR EMBL; GQ996564; ADN34679.1; -; Genomic_DNA. DR EMBL; MG825360; AUW30193.1; -; Genomic_DNA. DR UniGene; Hs.512152; -. DR MaxQB; Q8MH48; -. DR PRIDE; Q8MH48; -. DR Ensembl; ENST00000615098; ENSP00000482111; ENSG00000276051. DR Ensembl; ENST00000618812; ENSP00000479303; ENSG00000276051. DR UCSC; uc063tdc.1; human. DR HGNC; HGNC:4964; HLA-G. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR ChiTaRS; HLA-G; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:Q8MH48, KW ECO:0000213|MaxQB:Q8MH48, ECO:0000213|PeptideAtlas:Q8MH48}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 338 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014589035. FT TRANSMEM 308 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 338 AA; 38254 MW; 1F61E27AA78962FF CRC64; MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM NLQTLRGYYN QSEASSHTLQ WMIGCDLGSD GRLLRGYEQY AYDGKDYLAL NEDLRSWTAA DTAAQISKRK CEAANVAEQR RAYLEGTCVE WLHRYLENGK EMLQRADPPK THVTHHPVFD YEATLRCWAL GFYPAEIILT WQRDGEDQTQ DVELVETRPA GDGTFQKWAA VVVPSGEEQR YMCHVQHEGL PEPLMLRWKQ SSLPTIPIMG IVAGLVVLAA VVTGAAVAAV LWRKKSSD // ID Q8MHU0_PIG Unreviewed; 369 AA. AC Q8MHU0; DT 01-OCT-2002, integrated into UniProtKB/TrEMBL. DT 01-OCT-2002, sequence version 1. DT 12-SEP-2018, entry version 128. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:AAM20949.1}; GN Name=SLA-6 {ECO:0000313|EMBL:AAM20949.1}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|EMBL:AAM20949.1}; RN [1] {ECO:0000313|EMBL:AAM20949.1} RP NUCLEOTIDE SEQUENCE. RA Martens G.W., Baker J.E., Smith D.M.; RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ACA21769.1} RP NUCLEOTIDE SEQUENCE. RA Ho C.-S., Lee Y.-J., Smith D.M.; RT "Characterization of SLA alleles in Meishan pigs."; RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ASO67446.1} RP NUCLEOTIDE SEQUENCE. RA Gao C., Wang X., Quan J., Wang J., Tang X., Chen H.; RT "Molecular characterization of swine leukocyte antigen (SLA) gene RT diversity in Chinese Rongshui miniature pigs."; RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AF464008; AAM20949.1; -; mRNA. DR EMBL; EU432056; ACA21769.1; -; mRNA. DR EMBL; MF498799; ASO67446.1; -; mRNA. DR UniGene; Ssc.57070; -. DR STRING; 9823.ENSSSCP00000001483; -. DR PaxDb; Q8MHU0; -. DR PeptideAtlas; Q8MHU0; -. DR PRIDE; Q8MHU0; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR HOVERGEN; HBG016709; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Bgee; ENSSSCG00000001398; Expressed in 6 organ(s), highest expression level in lung. DR ExpressionAtlas; Q8MHU0; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 369 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5011211639. FT TRANSMEM 328 352 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 234 320 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 369 AA; 42002 MW; E2A552F236A197D2 CRC64; MQVTEPRTLL LVLSGSLALT ETWAGHLHHG PKDPRLEKGQ TRPQPLPVIG SHSLRYLHIL VSRPGHGSDL YSSVGFLDDT QFVRFSSDAA NPRVEPRAPW MEQEGREYWD RQTDIAKEHS KASRSNLRVI IGNHNHSQSE SHSFLWVSGC DVGSDGRILR GYEQFSYDGD DYIVLNEDLR SWTAISTVAQ IIRRKWEAEG VAEQYRAYLE IECVEWLRKY LEKGKDVLQR AVPPKTHVTR HPFYDNKVTL RCWALGFYPK EISLTWQQEG QDQTQDMELV ETRPSGDGTF QKWAALVVPS GEEQSYTCQV QHEGLQEPLT LRWEPPPLSL NLIMICIAVS VLVVTVLGTV IWRKRNSGGN RGNYVQAAS // ID Q8UUL6_ORYLA Unreviewed; 353 AA. AC Q8UUL6; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 05-JUL-2005, sequence version 4. DT 23-MAY-2018, entry version 112. DE SubName: Full=Classical MHC class I molecule, alpha-chain {ECO:0000313|EMBL:BAB83849.2}; DE SubName: Full=Major histocompatibility complex class I-related gene protein-like precursor {ECO:0000313|Ensembl:ENSORLP00000008513}; GN Name=Orla-UAA {ECO:0000313|EMBL:BAB83849.2}; GN Synonyms=orla-uaa {ECO:0000313|Ensembl:ENSORLP00000008513}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; OC Oryziinae; Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|EMBL:BAB83849.2}; RN [1] {ECO:0000313|EMBL:BAB83849.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Hd-rR {ECO:0000313|EMBL:BAB83849.2}; RX PubMed=11862394; DOI=10.1007/s00251-001-0427-3; RA Matsuo M.Y., Asakawa S., Shimizu N., Kimura H., Nonaka M.; RT "Nucleotide sequence of the MHC class I genomic region of a teleost, RT the medaka (Oryzias latipes)."; RL Immunogenetics 53:930-940(2002). RN [2] {ECO:0000313|Ensembl:ENSORLP00000008513, ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008513, RC ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., RA Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., RA Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., RA Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., RA Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., RA Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., RA Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome RT evolution."; RL Nature 447:714-719(2007). RN [3] {ECO:0000313|EMBL:BAB83849.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Hd-rR {ECO:0000313|EMBL:BAB83849.2}; RX PubMed=20174921; DOI=10.1007/s00251-010-0426-3; RA Nonaka M.I., Nonaka M.; RT "Evolutionary analysis of two classical MHC class I loci of the medaka RT fish, Oryzias latipes: haplotype-specific genomic diversity, locus- RT specific polymorphisms, and interlocus homogenization."; RL Immunogenetics 62:319-332(2010). RN [4] {ECO:0000313|Ensembl:ENSORLP00000008513} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008513}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BAAF04001391; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001392; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001393; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001394; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001395; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001396; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001397; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001398; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BAAF04001399; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BA000027; BAB83849.2; -; Genomic_DNA. DR EMBL; AB450992; BAJ07291.1; -; mRNA. DR RefSeq; NP_001265804.1; NM_001278875.1. DR UniGene; Ola.19917; -. DR UniGene; Ola.4188; -. DR STRING; 8090.ENSORLP00000008513; -. DR Ensembl; ENSORLT00000008514; ENSORLP00000008513; ENSORLG00000006772. DR GeneID; 101167218; -. DR KEGG; ola:101167218; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; TESWIAP; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF352993; -. DR Proteomes; UP000001038; Chromosome 11. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000001038}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 353 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014589082. FT TRANSMEM 302 324 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 285 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 353 AA; 39990 MW; A9C1B1270EE99BAF CRC64; MKIQLILCFL GLSFHGAAAV SHSLKYFYTA SSQVPNFPEF VSVGLVDDAQ ISHYDSDTRM TVPKQDWMAM DEQYWKRQTD IGLGHQQTFK ANIEILKPRF NQTGGVHVFQ WMYGCEWDEE TGAVNSFHQY GYDGEDFIAL DLKTESWIAP KQQAEITKHK WDNDKALMAG RKNYLTQICP EWLKKYVNYG SSSLMRKVLP SVSLLQKSSS SAVSCHATGF YPDRAELLWR RDGEEIHEGV EKGQILPNND GTFQMSVHLQ PPSGEDMQRY ECVFQLSGVK EDVITKLEKA KIRTNEGSSS QMLIIIGVLA AVMAVVAVSA FIFYKKKNAK RPPSPVDNKE IQEQMLQPEN PSA // ID Q95601_CHICK Unreviewed; 355 AA. AC Q95601; DT 01-FEB-1997, integrated into UniProtKB/TrEMBL. DT 01-FEB-1997, sequence version 1. DT 12-SEP-2018, entry version 161. DE SubName: Full=MHC class I alpha chain 2 {ECO:0000313|EMBL:BAF63006.1}; DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:AAP20110.1}; DE SubName: Full=MHC class I glycoprotein {ECO:0000313|EMBL:AAC17590.1}; DE SubName: Full=MHC class I molecule {ECO:0000313|EMBL:CAK54658.1}; DE SubName: Full=Major histocompatibility complex class I glycoprotein haplotype B21 {ECO:0000313|EMBL:AAB34945.1}; GN Name=BFIV21 {ECO:0000313|EMBL:AAB34945.1}; GN Synonyms=B-FIV {ECO:0000313|EMBL:AAC17590.1}, GN BF2 {ECO:0000313|EMBL:AAP20110.1, GN ECO:0000313|Ensembl:ENSGALP00000043493}; OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Phasianinae; Gallus. OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AAB34945.1}; RN [1] {ECO:0000313|EMBL:AAB34945.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=7621880; DOI=10.1002/eji.1830250740; RA Fulton J.E., Thacker E.L., Bacon L.D., Hunt H.D.; RT "Functional analysis of avian class I (BFIV) glycoproteins by epitope RT tagging and mutagenesis in vitro."; RL Eur. J. Immunol. 25:2069-2076(1995). RN [2] {ECO:0000313|EMBL:AAC17590.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=15I5 B21 congenic {ECO:0000313|EMBL:AAC17590.1}, and RC UCD BQ {ECO:0000313|EMBL:AAP20110.1}; RX PubMed=9553152; DOI=10.1007/s002510050383; RA Hunt H.D., Fulton J.E.; RT "Analysis of polymorphisms in the major expressed class I locus (B- RT FIV) of the chicken."; RL Immunogenetics 47:456-467(1998). RN [3] {ECO:0000313|EMBL:AAP20110.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=UCD BQ {ECO:0000313|EMBL:AAP20110.1}; RA Park S.Y., Min B.W.; RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSGALP00000043493, ECO:0000313|Proteomes:UP000000539} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000043493, RC ECO:0000313|Proteomes:UP000000539}; RX PubMed=15592404; DOI=10.1038/nature03154; RG International Chicken Genome Sequencing Consortium; RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., RA Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., RA Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., RA Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C., RA Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., RA Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., RA Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., RA Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., RA Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., RA Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., RA van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., RA Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., RA Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., RA Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., RA Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., RA Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., RA Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., RA Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., RA King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., RA Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., RA Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., RA Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., RA Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., RA Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., RA Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., RA Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., RA Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., RA Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., RA Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., RA Mardis E.R., Wilson R.K.; RT "Sequence and comparative analysis of the chicken genome provide RT unique perspectives on vertebrate evolution."; RL Nature 432:695-716(2004). RN [5] {ECO:0000213|PDB:3BEV, ECO:0000213|PDB:3BEW} RP X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 22-291, AND DISULFIDE BONDS. RX PubMed=18083574; DOI=10.1016/j.immuni.2007.11.007; RA Koch M., Camp S., Collen T., Avila D., Salomonsen J., Wallny H.J., RA van Hateren A., Hunt L., Jacob J.P., Johnston F., Marston D.A., RA Shaw I., Dunbar P.R., Cerundolo V., Jones E.Y., Kaufman J.; RT "Structures of an MHC class I molecule from B21 chickens illustrate RT promiscuous peptide binding."; RL Immunity 27:885-899(2007). RN [6] {ECO:0000313|EMBL:CAK54658.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=0 {ECO:0000313|EMBL:CAK54661.1}, and RC N {ECO:0000313|EMBL:CAK54658.1}; RX PubMed=17442958; RA Shaw I., Powell T.J., Marston D.A., Baker K., van Hateren A., RA Riegert P., Wiles M.V., Milne S., Beck S., Kaufman J.; RT "Different evolutionary histories of the two classical class I genes RT BF1 and BF2 illustrate drift and selection within the stable MHC RT haplotypes of chickens."; RL J. Immunol. 178:5744-5752(2007). RN [7] {ECO:0000313|EMBL:BAF63006.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=17513765; DOI=10.4049/jimmunol.178.11.7162; RA Shiina T., Briles W.E., Goto R.M., Hosomichi K., Yanagiya K., RA Shimizu S., Inoko H., Miller M.M.; RT "Extended gene map reveals tripartite motif, C-type lectin, and Ig RT superfamily type genes within a subregion of the chicken MHC-B RT affecting infectious disease."; RL J. Immunol. 178:7162-7172(2007). RN [8] {ECO:0000313|EMBL:BAG69455.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Cornell-N {ECO:0000313|EMBL:BAG69455.1}; RX PubMed=18714011; RA Hosomichi K., Miller M.M., Goto R.M., Wang Y., Suzuki S., Kulski J.K., RA Nishibori M., Inoko H., Hanzawa K., Shiina T.; RT "Contribution of mutation, recombination, and gene conversion to RT chicken MHC-B haplotype diversity."; RL J. Immunol. 181:3393-3399(2008). RN [9] {ECO:0000313|EMBL:ADZ31363.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=HBP-2 {ECO:0000313|EMBL:ADZ31363.1}; RA Dai Y., Liu X., Ye H., Liu S., Geng Z., Chen F., Yu W.; RT "Polymorphic sites are mainly located in the 1 and 2 domains of MHC RT class I chain from several Chinese native chicken breeds."; RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AIP84343.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=HNP-27 {ECO:0000313|EMBL:AIP84343.1}; RA Lai Y.H.; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000213|PDB:2YEZ, ECO:0000213|PDB:4CVZ, ECO:0000213|PDB:4D0B} RP X-RAY CRYSTALLOGRAPHY (2.39 ANGSTROMS) OF 1-291, AND DISULFIDE BONDS. RX PubMed=25860507; DOI=10.7554/ELIFE.05345; RA Chappell P., Meziane e.l. .K., Harrison M., Magiera L., Hermann C., RA Mears L., Wrobel A.G., Durant C., Nielsen L.L., Buus S., Ternette N., RA Mwangi W., Butter C., Nair V., Ahyee T., Duggleby R., Madrigal A., RA Roversi P., Lea S.M., Kaufman J.; RT "Expression levels of MHC class I molecules are inversely correlated RT with promiscuity of peptide binding."; RL Elife 4:e05345-e05345(2015). RN [12] {ECO:0000213|PDB:5ACZ, ECO:0000213|PDB:5AD0} RP X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS) OF 1-291, AND DISULFIDE BONDS. RA Chappell P.E., Roversi P., Harrison M.C., Kaufman J.F., Lea S.M.; RT "Complex of a B21 Chicken Mhc Class I Molecule and a 11mer Chicken RT Peptide."; RL Submitted (AUG-2015) to the PDB data bank. RN [13] {ECO:0000313|Ensembl:ENSGALP00000043493} RP IDENTIFICATION. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000043493}; RG Ensembl; RL Submitted (OCT-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AADN04000555; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; S78682; AAB34945.1; -; mRNA. DR EMBL; AF013493; AAC17590.1; -; mRNA. DR EMBL; AY234769; AAP20110.1; -; mRNA. DR EMBL; HQ435266; ADZ31363.1; -; mRNA. DR EMBL; KM014728; AIP84343.1; -; mRNA. DR EMBL; AB268588; BAF63006.1; -; Genomic_DNA. DR EMBL; AB426152; BAG69455.1; -; Genomic_DNA. DR EMBL; AM282697; CAK54658.1; -; Genomic_DNA. DR EMBL; AM282700; CAK54661.1; -; Genomic_DNA. DR PIR; I51309; I51309. DR RefSeq; NP_001026509.1; NM_001031338.1. DR UniGene; Gga.33600; -. DR UniGene; Gga.4973; -. DR PDB; 2YEZ; X-ray; 2.90 A; A=1-291. DR PDB; 3BEV; X-ray; 2.10 A; A=22-291. DR PDB; 3BEW; X-ray; 2.60 A; A/D=22-291. DR PDB; 4CVZ; X-ray; 2.39 A; A=1-291. DR PDB; 4D0B; X-ray; 2.80 A; A=22-291. DR PDB; 4D0C; X-ray; 2.81 A; A=1-291. DR PDB; 5ACZ; X-ray; 2.69 A; A=1-291. DR PDB; 5AD0; X-ray; 2.84 A; A=1-291. DR PDBsum; 2YEZ; -. DR PDBsum; 3BEV; -. DR PDBsum; 3BEW; -. DR PDBsum; 4CVZ; -. DR PDBsum; 4D0B; -. DR PDBsum; 4D0C; -. DR PDBsum; 5ACZ; -. DR PDBsum; 5AD0; -. DR SMR; Q95601; -. DR STRING; 9031.ENSGALP00000000138; -. DR Ensembl; ENSGALT00000079478; ENSGALP00000043493; ENSGALG00000041380. DR GeneID; 425389; -. DR KEGG; gga:425389; -. DR CTD; 425389; -. DR eggNOG; ENOG410II5V; Eukaryota. DR eggNOG; ENOG4111K8F; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; DWARYDC; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000000539; Chromosome 16. DR Bgee; ENSGALG00000024372; Expressed in 10 organ(s), highest expression level in female gonad. DR GO; GO:0009986; C:cell surface; IDA:AgBase. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0042605; F:peptide antigen binding; IDA:AgBase. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0000213|PDB:2YEZ, ECO:0000213|PDB:3BEV, KW ECO:0000213|PDB:3BEW, ECO:0000213|PDB:4CVZ}; KW Calcium {ECO:0000213|PDB:5AD0}; KW Complete proteome {ECO:0000313|Proteomes:UP000000539}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000213|PDB:5AD0}; KW Reference proteome {ECO:0000313|Proteomes:UP000000539}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 355 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014312559. FT TRANSMEM 298 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 203 282 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT METAL 106 106 Calcium. {ECO:0000213|PDB:5AD0}. FT METAL 244 244 Calcium. {ECO:0000213|PDB:5AD0}. FT DISULFID 120 182 {ECO:0000213|PDB:2YEZ, FT ECO:0000213|PDB:3BEV, FT ECO:0000213|PDB:3BEW}. FT DISULFID 220 276 {ECO:0000213|PDB:2YEZ, FT ECO:0000213|PDB:3BEV, FT ECO:0000213|PDB:3BEW}. SQ SEQUENCE 355 AA; 38960 MW; A751A09C46D94EE9 CRC64; MGSCGALGLG LLLAAVCGAA AELHTLRYIR TAMTDPGPGL PWFVDVGYVD GELFMHYNST ARRAVPRTEW IAANTDQQYW DRETQIVQGS EQINRENLDI LRRRYNQTGG SHTVQWMSGC DILEDGTIRG YHQAAYDGRD FVAFDKGTMT LTAAVPEAVP TKRKWEEGGY AEGLKQYLEE TCVEWLRRYV EYGKAELGRR ERPEVRVWGK EADGILTLSC RAHGFYPRPI VVSWLKDGAV RGQDAQSGGI VPNGDGTYHT WVTIDAQPGD GDKYQCRVEH ASLPQPGLYS WEPPQPNLVP IVAGVAVAIV AIAIVVGVGF IIYRRHAGKK GKGYNIAPDR EGGSSSSSTG SNPSI // ID Q95II0_RAT Unreviewed; 375 AA. AC Q95II0; F7FP91; DT 01-DEC-2001, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 1. DT 12-SEP-2018, entry version 151. DE SubName: Full=MHC class Ib antigen {ECO:0000313|EMBL:CAC48028.1}; DE SubName: Full=RT1 class I, CE5 {ECO:0000313|EMBL:AAH98841.1}; DE SubName: Full=RT1 class I, locus CE5 {ECO:0000313|Ensembl:ENSRNOP00000057699}; GN Name=RT1-CE5 {ECO:0000313|EMBL:AAH98841.1, GN ECO:0000313|Ensembl:ENSRNOP00000057699, ECO:0000313|RGD:1595868}; GN Synonyms=LOC100364956 {ECO:0000313|RGD:1595868}, GN RT1-E2 {ECO:0000313|EMBL:CAC48028.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:CAC48028.1}; RN [1] {ECO:0000313|EMBL:CAC48028.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:CAC48028.1}; RX PubMed=11238641; RA Ioannidu S., Walter L., Dressel R., Gunther E.; RT "Physical map and expression profile of genes of the telomeric class I RT gene region of the rat MHC."; RL J. Immunol. 166:3957-3965(2001). RN [2] {ECO:0000313|EMBL:CAC48028.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:CAC48028.1}; RA Amadou C., Lau P., Brun H., Joly E.; RT "Genomic sequence of a rat MHC class Ib gene, RT1-E2(n)."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:CAC48028.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:CAC48028.1}; RA Lau P., Amadou C., McLaren F.H., Brun H., Graham M., Butcher G.W., RA Joly E.; RT "RT1-E2 sequences show high conservation amongst different rat RT strains, but variable number of loci between MHC haplotypes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:AAH98841.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Spleen {ECO:0000313|EMBL:AAH98841.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] {ECO:0000313|Ensembl:ENSRNOP00000057699, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000057699, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [6] {ECO:0000313|Ensembl:ENSRNOP00000057699} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000057699}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [7] {ECO:0000313|EMBL:AVP72132.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:AVP72132.1}; RC TISSUE=Spleen {ECO:0000313|EMBL:AVP72132.1}; RX PubMed=29531166; RA Dai K.Z., Ryan J.C., Naper C., Vaage J.T.; RT "Identification of MHC Class Ib Ligands for Stimulatory and Inhibitory RT Ly49 Receptors and Induction of Potent NK Cell Alloresponses in RT Rats."; RL J. Immunol. 200:2847-2859(2018). RN [8] {ECO:0000313|EMBL:AVP72132.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:AVP72132.1}; RC TISSUE=Spleen {ECO:0000313|EMBL:AVP72132.1}; RA Cohen D.B., Kent A.D.; RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AABR07044408; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC098841; AAH98841.1; -; mRNA. DR EMBL; MG963102; AVP72132.1; -; mRNA. DR EMBL; AJ315490; CAC48028.1; -; Genomic_DNA. DR RefSeq; NP_001008843.1; NM_001008843.2. DR RefSeq; NP_001029158.1; NM_001033986.1. DR UniGene; Rn.216323; -. DR STRING; 10116.ENSRNOP00000057699; -. DR Ensembl; ENSRNOT00000060980; ENSRNOP00000057699; ENSRNOG00000000723. DR GeneID; 309607; -. DR KEGG; rno:309607; -. DR CTD; 309607; -. DR RGD; 1595868; RT1-CE5. DR GeneTree; ENSGT00760000118960; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR OMA; QPRFIAV; -. DR OrthoDB; EOG091G09OH; -. DR TreeFam; TF336617; -. DR Reactome; R-RNO-1236974; ER-Phagosome pathway. DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-RNO-6798695; Neutrophil degranulation. DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000000723; Expressed in 9 organ(s), highest expression level in spleen. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 375 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015099577. FT TRANSMEM 312 332 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 375 AA; 42225 MW; 8E900CC4FDDD143E CRC64; MGAMAPRTLL LLLAAALAPT RTRAGSHSLR YFHTAVSRPG LGEPRFIIVG YVDHTEFVRY DSDAENPRYE PRARWMEREG PEYWEQQTQI VKGHEWSFRV SLRNLLGYYN QSEGGSHTLQ VMSGCDMGSD QSLRRGYEQY AYDGRDYISL NEDLKTWSAA DLAAQITLNK WDQAGELDYY KAYLEGPCLE WLLRYLEHGK ETLMRSDPPK AHVTLHPRPE GDVTLRCWAL GFYPADITLT WQLNGEDLTQ DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCLVEHEGL PEPLTFRWEA PPSTNSNTGM SVILGTVTII AVMAIIVVVA VIRTVVRKRW IKTAFLLTSG KGVYTPAPGR DSSQSSDVSL PDCKA // ID Q96QC4_HUMAN Unreviewed; 332 AA. AC Q96QC4; DT 01-DEC-2001, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 1. DT 12-SEP-2018, entry version 157. DE SubName: Full=MHC class I polypeptide-related sequence A, isoform CRA_c {ECO:0000313|EMBL:EAX03396.1}; DE SubName: Full=Stress inducible class I homolog {ECO:0000313|EMBL:BAB63308.1}; DE SubName: Full=cDNA FLJ60820, highly similar to Homo sapiens MHC class I polypeptide-related sequence A (MICA), mRNA {ECO:0000313|EMBL:BAG61187.1}; GN Name=MICA {ECO:0000313|EMBL:BAB63308.1, GN ECO:0000313|Ensembl:ENSP00000394553}; GN ORFNames=hCG_2001511 {ECO:0000313|EMBL:EAX03396.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAB63308.1}; RN [1] {ECO:0000313|EMBL:EAX03396.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11181995; DOI=10.1126/science.1058040; RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., RA Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., RA Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G., RA Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., RA Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., RA Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., RA Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., RA Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., RA Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., RA Brandon R., Cargill M., Chandramouliswaran I., Charlab R., RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., RA Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., RA Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., RA Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., RA Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., RA Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., RA Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., RA Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., RA Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., RA Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., RA Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., RA Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., RA Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., RA Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., RA Kline L., Koduru S., Love A., Mann F., May D., McCawley S., RA McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., RA Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., RA Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., RA Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., RA Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., RA Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., RA Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., RA Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., RA Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., RA Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., RA Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., RA Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., RA Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., RA Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., RA McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., RA Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.; RT "The sequence of the human genome."; RL Science 291:1304-1351(2001). RN [2] {ECO:0000313|EMBL:BAB63308.1} RP NUCLEOTIDE SEQUENCE. RA Hirakawa M., Yamaguchi H., Imai K., Shimada J.; RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSP00000394553, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [4] {ECO:0000313|EMBL:BAB63308.1} RP NUCLEOTIDE SEQUENCE. RA Shiina S., Tamiya G., Oka A., Inoko H.; RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."; RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:EAX03396.1} RP NUCLEOTIDE SEQUENCE. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:BAG61187.1} RP NUCLEOTIDE SEQUENCE. RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., RA Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., RA Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., RA Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project focused on splicing variants."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|Ensembl:ENSP00000413079} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [8] {ECO:0000313|Ensembl:ENSP00000394553} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. RN [9] {ECO:0000313|EMBL:ARB08519.1} RP NUCLEOTIDE SEQUENCE. RA Norman P.J., Norberg S.J., Guethlein L.A., Nemat-Gorgani N., RA Ronaghi M., Parham P.; RT "MIC gene sequence alleles derived from homozygous individuals."; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL645933; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL669854; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX005439; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX119958; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KY500931; ARB08519.1; -; Genomic_DNA. DR EMBL; KY500934; ARB08522.1; -; Genomic_DNA. DR EMBL; KY500935; ARB08523.1; -; Genomic_DNA. DR EMBL; KY500937; ARB08525.1; -; Genomic_DNA. DR EMBL; KY500938; ARB08526.1; -; Genomic_DNA. DR EMBL; KY500939; ARB08527.1; -; Genomic_DNA. DR EMBL; BA000025; BAB63308.1; -; Genomic_DNA. DR EMBL; AK299135; BAG61187.1; -; mRNA. DR EMBL; CH471081; EAX03396.1; -; Genomic_DNA. DR RefSeq; NP_001170990.1; NM_001177519.2. DR RefSeq; NP_001276081.1; NM_001289152.1. DR RefSeq; NP_001276082.1; NM_001289153.1. DR RefSeq; NP_001276083.1; NM_001289154.1. DR UniGene; Hs.130838; -. DR SMR; Q96QC4; -. DR IntAct; Q96QC4; 2. DR STRING; 9606.ENSP00000365394; -. DR MaxQB; Q96QC4; -. DR PRIDE; Q96QC4; -. DR Ensembl; ENST00000415525; ENSP00000416941; ENSG00000231225. DR Ensembl; ENST00000427477; ENSP00000394553; ENSG00000233051. DR Ensembl; ENST00000449934; ENSP00000413079; ENSG00000204520. DR Ensembl; ENST00000546529; ENSP00000446655; ENSG00000231225. DR Ensembl; ENST00000547767; ENSP00000447026; ENSG00000233051. DR GeneID; 100507436; -. DR UCSC; uc003ntk.3; human. DR CTD; 100507436; -. DR EuPathDB; HostDB:ENSG00000204520.12; -. DR HGNC; HGNC:7090; MICA. DR OpenTargets; ENSG00000204520; -. DR PharmGKB; PA30811; -. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000231246; -. DR HOVERGEN; HBG106364; -. DR OMA; LVLQSHW; -. DR OrthoDB; EOG091G0ANY; -. DR TreeFam; TF342166; -. DR ChiTaRS; MICA; human. DR GenomeRNAi; 100507436; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204520; Expressed in 204 organ(s), highest expression level in ectocervix. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q96QC4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 332 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014589245. FT DOMAIN 207 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 332 AA; 37834 MW; A8D8C5080781CB90 CRC64; MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLAEVH LDGQPFLRYD RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL AHIKDQKEGL HSLQEIRVCE IHEDNSTRSS QHFYYDGELF LSQNLETEEW TVPQSSRAQT LAMNVRNFLK EDAMKTKTHY HAMHADCLQE LRRYLESGVV LRRTVPPMVN VTRSEASEGN ITVTCRASSF YPRNIILTWR QDGVSLSHDT QQWGDVLPDG NGTYQTWVAT RICRGEEQRF TCYMEHSGNH STHPVPSGKV LVLQSHWQTF HVSAVAAGCC YFCYYYFLCP LL // ID Q98247_MCV1 Unreviewed; 395 AA. AC Q98247; DT 01-FEB-1997, integrated into UniProtKB/TrEMBL. DT 01-FEB-1997, sequence version 1. DT 20-JUN-2018, entry version 90. DE SubName: Full=MC080R {ECO:0000313|EMBL:AAC55208.1}; GN Name=MC080R {ECO:0000313|EMBL:AAC55208.1}; OS Molluscum contagiosum virus subtype 1 (MOCV) (MCVI). OC Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae; OC Molluscipoxvirus. OX NCBI_TaxID=10280 {ECO:0000313|Proteomes:UP000000869}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AAC55208.1, ECO:0000313|Proteomes:UP000000869} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=8670425; DOI=10.1126/science.273.5276.813; RA Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., RA Moss B.; RT "Genome sequence of a human tumorigenic poxvirus: prediction of RT specific host response-evasion genes."; RL Science 273:813-816(1996). RN [2] {ECO:0000313|EMBL:AQY16829.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Madrid 2016_3 {ECO:0000313|EMBL:AQY16829.1}, RC Madrid 2016_6 {ECO:0000313|EMBL:AQY17008.1}, and RC Madrid 2016_7 {ECO:0000313|EMBL:AQY17187.1}; RA Lopez-Bueno A., Parras-Molto M., Lopez-Barrantes O., Belda S., RA Alejo A.; RT "Recombination events and variability among full-length genomes of co- RT circulating molluscum contagiosum virus subtypes 1 and 2."; RL J. Gen. Virol. 0:0-0(2017). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; U60315; AAC55208.1; -; Genomic_DNA. DR EMBL; KY040275; AQY16829.1; -; Genomic_DNA. DR EMBL; KY040276; AQY17008.1; -; Genomic_DNA. DR EMBL; KY040277; AQY17187.1; -; Genomic_DNA. DR PIR; T30682; T30682. DR RefSeq; NP_044031.1; NC_001731.1. DR ProteinModelPortal; Q98247; -. DR GeneID; 1487099; -. DR KEGG; vg:1487099; -. DR Proteomes; UP000000869; Genome. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000869}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000869}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 27 45 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 239 322 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 395 AA; 43150 MW; 39BBD1B8703F4808 CRC64; MTGTLILLLA CVLNAMAQLL ARVCMAAATL ARMLALSVAF LLALARTRTG LRAILVALLL RALLRALLAH AHAHTLSYVA AVVYTPGNAQ PLLLAEGSIN DLVFMRYHRQ SGSVLPSPEW APSVYFHDEL WMLNARVDAL RSLSVPGARL GNGTLGARSL QLAVGCEKVA GDASFWDLVY DGTEQICMHA DATECEPGLP VHARLAKERW TRLGAHSHAL EQRCLQWLER HLGARTNRPV VSVPLLSVVA YADGSGTRLR CTASGFSPRD VRLLWTRDGI PGPDYDFVEP RPSGDGSFQQ WAELVVAAGL ETHYVCVASH DSWKSSWRAR WEEGKRRVAT SARVAPLATI AEMLVALELM LILRERRLTL GALATMLACS MPNLLPQALR ERAGF // ID Q9BCZ1_MOUSE Unreviewed; 344 AA. AC Q9BCZ1; DT 01-JUN-2001, integrated into UniProtKB/TrEMBL. DT 01-JUN-2001, sequence version 1. DT 12-SEP-2018, entry version 157. DE SubName: Full=H2-T22 protein {ECO:0000313|EMBL:AAH03819.1}; DE SubName: Full=Histocompatibility 2, T region locus 22 {ECO:0000313|Ensembl:ENSMUSP00000056041}; GN Name=H2-T22 {ECO:0000313|EMBL:AAH03819.1, GN ECO:0000313|Ensembl:ENSMUSP00000056041, ECO:0000313|MGI:MGI:95956}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH03819.1}; RN [1] {ECO:0000313|EMBL:AAH03819.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Mix FVB/N {ECO:0000313|EMBL:AAH03819.1}; RC TISSUE=Mammary tumor. WAP-TGF alpha model. 7 months old RC {ECO:0000313|EMBL:AAH03819.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000213|PDB:1YPZ} RP X-RAY CRYSTALLOGRAPHY (3.40 ANGSTROMS) OF 29-288, AND DISULFIDE BONDS. RX PubMed=15821084; DOI=10.1126/science.1106885; RA Adams E.J., Chien Y.H., Garcia K.C.; RT "Structure of a gammadelta T cell receptor in complex with the RT nonclassical MHC T22."; RL Science 308:227-231(2005). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000056041} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000056041}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000056041} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000056041}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC112970; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC003819; AAH03819.1; -; mRNA. DR RefSeq; NP_001334311.1; NM_001347382.1. DR RefSeq; XP_017172753.1; XM_017317264.1. DR UniGene; Mm.195061; -. DR PDB; 1YPZ; X-ray; 3.40 A; A/C=29-288. DR PDBsum; 1YPZ; -. DR IntAct; Q9BCZ1; 1. DR Ensembl; ENSMUST00000058801; ENSMUSP00000056041; ENSMUSG00000056116. DR GeneID; 15039; -. DR KEGG; mmu:15039; -. DR UCSC; uc008cjv.1; mouse. DR CTD; 15039; -. DR MGI; MGI:95956; H2-T22. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR KO; K06751; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000056116; Expressed in 80 organ(s), highest expression level in basioccipital bone. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0000213|PDB:1YPZ}; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Proteomics identification {ECO:0000213|EPD:Q9BCZ1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 344 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015099646. FT DOMAIN 197 275 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DISULFID 126 176 {ECO:0000213|PDB:1YPZ}. FT DISULFID 135 158 {ECO:0000213|PDB:1YPZ}. FT DISULFID 215 271 {ECO:0000213|PDB:1YPZ}. SQ SEQUENCE 344 AA; 39100 MW; A8FE34EE998E614C CRC64; MSWVLRAAVV CALLLQLDAR PSWTRIPLGS HSLRYFYTAV SRPGLGEPWF IIVGYVDDMQ VLRFSSKEET PRMAPWLEQE EADNWEQQTR IVTIQGQLSE RNLMTLVHFY NKSMDDSHTL QWLQGCDVEP DRHLCLWYNQ LAYDSEDLPT LNENPSSCTV GNSTVPHISQ DLKSHCSDLL QKYLEKGKER LLRSDPPKAH VTRHPRPEGD VTLRCWALGF YPADITLTWQ LNGEELTQDM ELVETRPAGD GTFQKWAAVV VPLGKEQSYT CHVYHEGLPE PLILRWGGRG RRDTQEAGRD SPQDSSKTVV DDEEMGVCFW KIKSCKTCLG HSPGTSVGES LLSP // ID Q9GJ45_HUMAN Unreviewed; 326 AA. AC Q9GJ45; DT 01-MAR-2001, integrated into UniProtKB/TrEMBL. DT 01-MAR-2001, sequence version 1. DT 18-JUL-2018, entry version 132. DE SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000480039}; DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:AAG27625.1}; GN Name=HLA-A {ECO:0000313|EMBL:AAG27625.1, GN ECO:0000313|Ensembl:ENSP00000480039}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAG27625.1}; RN [1] {ECO:0000313|EMBL:AAG27625.1} RP NUCLEOTIDE SEQUENCE. RA Sayer D.C., Cassell H.S., Diviney M., Hart C., Holdsworth R., RA Christiansen F.T.; RT "A point mutation in the exon 5 splice site of an HLA-A32 allele RT resulting in alternative splicing including mRNA that lacks exon 5 and RT reduced expression of A32."; RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSP00000480039, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [3] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [4] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [5] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [6] {ECO:0000313|Ensembl:ENSP00000480039} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX005091; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX088647; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX120004; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AF287958; AAG27625.1; -; mRNA. DR UniGene; Hs.181244; -. DR UniGene; Hs.713441; -. DR MaxQB; Q9GJ45; -. DR PRIDE; Q9GJ45; -. DR Ensembl; ENST00000612644; ENSP00000480039; ENSG00000223980. DR UCSC; uc011jdz.3; human. DR HGNC; HGNC:4931; HLA-A. DR HOVERGEN; HBG016709; -. DR ChiTaRS; HLA-A; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Proteomics identification {ECO:0000213|EPD:Q9GJ45, KW ECO:0000213|MaxQB:Q9GJ45, ECO:0000213|PeptideAtlas:Q9GJ45}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 326 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014589408. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 326 AA; 37012 MW; 2041806E868A83DE CRC64; MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAHSQTDRE SLRIALRYYN QSEAGSHTIQ MMYGCDVGPD GRLLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWDR KGGSYSQAAS SDSAQGSDMS LTACKV // ID Q9R105_RAT Unreviewed; 272 AA. AC Q9R105; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 12-SEP-2018, entry version 137. DE SubName: Full=Hemochromatosis gene product HFE splice variant delE2 {ECO:0000313|EMBL:AAD49965.1}; DE SubName: Full=Hemochromatosis, isoform CRA_b {ECO:0000313|EMBL:EDL86570.1}; DE SubName: Full=Hereditary hemochromatosis protein homolog {ECO:0000313|Ensembl:ENSRNOP00000022809}; GN Name=Hfe {ECO:0000313|EMBL:EDL86570.1, GN ECO:0000313|Ensembl:ENSRNOP00000022809, ECO:0000313|RGD:2793}; GN ORFNames=rCG_45141 {ECO:0000313|EMBL:EDL86570.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAD49965.1}; RN [1] {ECO:0000313|EMBL:AAD49965.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Wistar {ECO:0000313|EMBL:AAD49965.1}; RC TISSUE=Testis {ECO:0000313|EMBL:AAD49965.1}; RA Liew Y.-F., Shaw N.-S.; RT "Alternative splice variant of the hemochromatosis gene HFE in iron RT overloaded rats."; RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSRNOP00000022809, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000022809, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [3] {ECO:0000313|EMBL:EDL86570.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL86570.1}; RX PubMed=15632090; DOI=10.1101/gr.2889405; RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., RA Istrail S., Li P., Sutton G.; RT "Gene and alternative splicing annotation with AIR."; RL Genome Res. 15:54-66(2005). RN [4] {ECO:0000313|EMBL:EDL86570.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL86570.1}; RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., RA Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., RA Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|Ensembl:ENSRNOP00000022809} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000022809}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC130391; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AF176534; AAD49965.1; -; mRNA. DR EMBL; CH474064; EDL86570.1; -; Genomic_DNA. DR RefSeq; NP_001166905.1; NM_001173434.1. DR UniGene; Rn.42931; -. DR Ensembl; ENSRNOT00000022809; ENSRNOP00000022809; ENSRNOG00000016967. DR GeneID; 29199; -. DR CTD; 3077; -. DR RGD; 2793; Hfe. DR eggNOG; ENOG410IFNV; Eukaryota. DR eggNOG; ENOG4111CQR; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR Proteomes; UP000002494; Chromosome 17. DR Bgee; ENSRNOG00000016967; Expressed in 9 organ(s), highest expression level in liver. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q9R105}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 272 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015299953. FT TRANSMEM 230 253 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 132 221 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 272 AA; 30757 MW; 1D91063CCBEF5502 CRC64; MDRSAGLPVR LLLLLLLLLL WSVAPQALRP VTKLRVVPES HILQVILGCE VHEDNSTSGF WKYGYDGQDH LEFCPKTLNW SAAEPRAWAT KMEWEEHRIR ARQSRDYLQR DCPQQLKQVL ELQRGVLGQQ VPTLVKVTRH WASTGTSLRC QALNFFPQNI TMRWLKDSQP LDAKDVNPEN VLPNGDGTYQ GWLTLAVAPG EETRFSCQVE HPGLDQPLTA TWEPSRSQDM IIGIISGITI CAIFFVGILI LVLRKRKVSG GTMGDYVLTE CE // ID R4GBI9_ANOCA Unreviewed; 363 AA. AC R4GBI9; DT 26-JUN-2013, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 1. DT 12-SEP-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000022668}; GN Name=LOC100552615 {ECO:0000313|Ensembl:ENSACAP00000022668}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000022668, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000022668} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000022668} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR RefSeq; XP_016853044.1; XM_016997555.1. DR Ensembl; ENSACAT00000030085; ENSACAP00000022668; ENSACAG00000029516. DR GeneID; 100552615; -. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000029516; Expressed in 4 organ(s), highest expression level in heart. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 363 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004365589. FT TRANSMEM 307 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 201 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 363 AA; 40879 MW; 8A6D1CDF4188453D CRC64; MGQPWLLGAA ALAFLLASIT GAPSHSLSYL FTVVSEPGPG LPQFMVSGHF DGQLFASYDS ERRSGVPRTE WMEEMVELDP GYWDWLNRNA RNSEQIFKWQ IGTVMRHYNH SGGLHTMQWV FSCTLSEDGR KGGSNKFSYD GKEALSFDKE TLRWTASDAV AEGYKEKWEA EAGRTQRSKV YLEDKCISML HKHLEVRKGV PRKRVAPVVK VTHKAGIGGL ETLVCHIHGF YPKDIDATWR KDEEVREQET LRGNITPNSD GTYNTWISIE VDEKDRDKYQ CHVEHDSLPE GAGSDLHFPV VECGAPILPW IIVGSALVLI LIVTLIVIIL KKRGSQNAPA TNAEMQEMNP PQRRRRICIS VAE // ID R7VYA0_COLLI Unreviewed; 183 AA. AC R7VYA0; DT 24-JUL-2013, integrated into UniProtKB/TrEMBL. DT 24-JUL-2013, sequence version 1. DT 28-FEB-2018, entry version 22. DE SubName: Full=Class I histocompatibility antigen, F10 alpha chain {ECO:0000313|EMBL:EMC90777.1}; DE Flags: Fragment; GN ORFNames=A306_00031 {ECO:0000313|EMBL:EMC90777.1}; OS Columba livia (Rock dove). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba. OX NCBI_TaxID=8932 {ECO:0000313|EMBL:EMC90777.1}; RN [1] {ECO:0000313|EMBL:EMC90777.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC TISSUE=Blood {ECO:0000313|EMBL:EMC90777.1}; RX PubMed=23371554; DOI=10.1126/science.1230422; RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M., RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A., RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.; RT "Genomic diversity and evolution of the head crest in the rock RT pigeon."; RL Science 339:1063-1067(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB387310; EMC90777.1; -; Genomic_DNA. DR ProteinModelPortal; R7VYA0; -. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; FT DOMAIN 87 168 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 183 183 {ECO:0000313|EMBL:EMC90777.1}. SQ SEQUENCE 183 AA; 20897 MW; 1A817B73721C03CD CRC64; MYGCDLLEDG STRGYFQSAY DGKDYIALDL DTMTFTAADV AAQNTKRKWE KDGAEAERVK HYVENTCIEW LRRYVSYGHN VLERKEPPTV RVSASEAHDG ILTLRCRAFG FYPRPIGVSW LKDGEVRDQD TEWGGIVPNS DGTYYTWAAI EARPEDRDRY QCRVDHASLP KPQLFASGES RGR // ID ULBP5_HUMAN Reviewed; 334 AA. AC Q6H3X3; Q6H3X2; DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot. DT 19-JUL-2004, sequence version 1. DT 12-SEP-2018, entry version 122. DE RecName: Full=UL-16 binding protein 5; DE AltName: Full=Retinoic acid early transcript 1G protein {ECO:0000312|HGNC:HGNC:16795}; DE Flags: Precursor; GN Name=RAET1G {ECO:0000303|PubMed:19223974, GN ECO:0000312|HGNC:HGNC:16795}; GN Synonyms=ULBP5 {ECO:0000303|PubMed:19223974}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] {ECO:0000305, ECO:0000312|EMBL:AAO22238.1} RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR RP LOCATION, TISSUE SPECIFICITY, AND INTERACTION WITH KLRK1 AND CMV UL16. RX PubMed=15240696; DOI=10.4049/jimmunol.173.2.1078; RA Bacon L., Eagle R.A., Meyer M., Easom N., Young N.T., Trowsdale J.; RT "Two human ULBP/RAET1 molecules with transmembrane regions are ligands RT for NKG2D."; RL J. Immunol. 173:1078-1084(2004). RN [2] RP ALTERNATIVE SPLICING (ISOFORM 3), AND INTERACTION WITH KLRK1. RX PubMed=18544572; DOI=10.1093/intimm/dxn057; RA Cao W., Xi X., Wang Z., Dong L., Hao Z., Cui L., Ma C., He W.; RT "Four novel ULBP splice variants are ligands for human NKG2D."; RL Int. Immunol. 20:981-991(2008). RN [3] RP FUNCTION, INTERACTION WITH KLRK1 AND CMV UL16, AND TISSUE SPECIFICITY. RX PubMed=19658097; DOI=10.1002/eji.200939502; RA Eagle R.A., Traherne J.A., Hair J.R., Jafferji I., Trowsdale J.; RT "ULBP6/RAET1L is an additional human NKG2D ligand."; RL Eur. J. Immunol. 39:3207-3216(2009). RN [4] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-82. RC TISSUE=Leukemic T-cell; RX PubMed=19349973; DOI=10.1038/nbt.1532; RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., RA Schiess R., Aebersold R., Watts J.D.; RT "Mass-spectrometric identification and relative quantification of N- RT linked cell surface glycoproteins."; RL Nat. Biotechnol. 27:378-386(2009). RN [5] RP SUBCELLULAR LOCATION (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY. RX PubMed=19223974; DOI=10.1371/journal.pone.0004503; RA Eagle R.A., Flack G., Warford A., Martinez-Borra J., Jafferji I., RA Traherne J.A., Ohashi M., Boyle L.H., Barrow A.D., Caillat-Zucman S., RA Young N.T., Trowsdale J.; RT "Cellular expression, trafficking, and function of two isoforms of RT human ULBP5/RAET1G."; RL PLoS ONE 4:E4503-E4503(2009). RN [6] RP SUBCELLULAR LOCATION, GPI-ANCHOR AT GLY-218, PROTEOLYTIC PROCESSING, RP AND MUTAGENESIS OF SER-217. RX PubMed=20304922; DOI=10.1074/jbc.M109.077636; RA Ohashi M., Eagle R.A., Trowsdale J.; RT "Post-translational modification of the NKG2D ligand RAET1G leads to RT cell surface expression of a glycosylphosphatidylinositol-linked RT isoform."; RL J. Biol. Chem. 285:16408-16415(2010). CC -!- FUNCTION: Isoform 1: Binds and activates the KLRK1/NKG2D receptor, CC mediating natural killer cell cytotoxicity. CC {ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:18544572, CC ECO:0000269|PubMed:19658097}. CC -!- FUNCTION: Isoform 3: Down-regulates the expression of KLRK1 and CC stimulates natural killer cells to secrete IFNG. CC {ECO:0000269|PubMed:18544572}. CC -!- FUNCTION: Isoform 2: Stimulates natural killer cells to secrete CC IFNG. {ECO:0000269|PubMed:18544572}. CC -!- SUBUNIT: Interacts with KLRK1/NKG2D. {ECO:0000269|PubMed:15240696, CC ECO:0000269|PubMed:18544572, ECO:0000269|PubMed:19658097}. CC -!- SUBUNIT: (Microbial infection) In CMV-infected cells, interacts CC with the viral glycoprotein UL16; this interaction causes RAET1G CC retention in the endoplasmic reticulum and cis-Golgi and prevents CC binding to and activation of KLRK1/NKG2D, providing CMV with an CC immune evasion mechanism. {ECO:0000269|PubMed:15240696, CC ECO:0000269|PubMed:19658097}. CC -!- INTERACTION: CC P26718:KLRK1; NbExp=6; IntAct=EBI-458334, EBI-458344; CC -!- SUBCELLULAR LOCATION: Isoform 1: Cell membrane CC {ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:19223974, CC ECO:0000269|PubMed:20304922}; Lipid-anchor, GPI-anchor CC {ECO:0000269|PubMed:20304922}. Endoplasmic reticulum CC {ECO:0000269|PubMed:19223974, ECO:0000269|PubMed:20304922}. CC Note=Mainly found intracellularly. {ECO:0000269|PubMed:15240696, CC ECO:0000269|PubMed:19223974, ECO:0000269|PubMed:20304922}. CC -!- SUBCELLULAR LOCATION: Isoform 2: Secreted CC {ECO:0000269|PubMed:19223974}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1 {ECO:0000269|PubMed:15240696}; Synonyms=RAET1G1 CC {ECO:0000303|PubMed:15240696}; CC IsoId=Q6H3X3-1; Sequence=Displayed; CC Name=2 {ECO:0000269|PubMed:15240696}; Synonyms=RAET1G2 CC {ECO:0000303|PubMed:15240696}; CC IsoId=Q6H3X3-2; Sequence=VSP_051621, VSP_051622; CC Name=3; Synonyms=RAET1G3 {ECO:0000303|PubMed:18544572}; CC IsoId=Q6H3X3-3; Sequence=VSP_059264, VSP_051622; CC -!- TISSUE SPECIFICITY: Isoform 1 is highly expressed in colon and in CC a number of tumor cell lines and highly restricted in normal CC tissues. Both isoforms are frequently expressed in cell lines CC derived from epithelial cancers, and in primary breast cancers. CC {ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:19223974, CC ECO:0000269|PubMed:19658097}. CC -!- PTM: The functional form is cleaved C-terminally of the GPI-anchor CC and yields a 28 kDa protein. {ECO:0000269|PubMed:20304922}. CC -!- MISCELLANEOUS: UL16-binding proteins (ULBPs) are unusual members CC of the extended MHC class I superfamily. They do not contain the CC alpha 3 domain and lack a transmembrane domain. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000255}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AY172579; AAO22238.1; -; mRNA. DR EMBL; AY172580; AAO22239.1; -; mRNA. DR CCDS; CCDS43514.1; -. [Q6H3X3-1] DR RefSeq; NP_001001788.2; NM_001001788.3. [Q6H3X3-1] DR UniGene; Hs.535023; -. DR UniGene; Hs.558792; -. DR ProteinModelPortal; Q6H3X3; -. DR SMR; Q6H3X3; -. DR IntAct; Q6H3X3; 2. DR STRING; 9606.ENSP00000356329; -. DR iPTMnet; Q6H3X3; -. DR PhosphoSitePlus; Q6H3X3; -. DR BioMuta; RAET1G; -. DR DMDM; 56749591; -. DR MaxQB; Q6H3X3; -. DR PaxDb; Q6H3X3; -. DR PeptideAtlas; Q6H3X3; -. DR PRIDE; Q6H3X3; -. DR ProteomicsDB; 66338; -. DR ProteomicsDB; 66339; -. [Q6H3X3-2] DR TopDownProteomics; Q6H3X3-1; -. [Q6H3X3-1] DR Ensembl; ENST00000367360; ENSP00000356329; ENSG00000203722. [Q6H3X3-1] DR Ensembl; ENST00000367361; ENSP00000356330; ENSG00000203722. [Q6H3X3-2] DR GeneID; 353091; -. DR KEGG; hsa:353091; -. DR UCSC; uc010kii.1; human. [Q6H3X3-1] DR CTD; 353091; -. DR DisGeNET; 353091; -. DR EuPathDB; HostDB:ENSG00000203722.7; -. DR GeneCards; RAET1G; -. DR H-InvDB; HIX0025204; -. DR HGNC; HGNC:16795; RAET1G. DR HPA; HPA062673; -. DR MIM; 609244; gene. DR neXtProt; NX_Q6H3X3; -. DR OpenTargets; ENSG00000203722; -. DR PharmGKB; PA134897742; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR HOGENOM; HOG000070028; -. DR InParanoid; Q6H3X3; -. DR KO; K07987; -. DR OMA; QIAKRPL; -. DR OrthoDB; EOG091G0I62; -. DR PhylomeDB; Q6H3X3; -. DR TreeFam; TF341724; -. DR Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins. DR GenomeRNAi; 353091; -. DR PRO; PR:Q6H3X3; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000203722; Expressed in 81 organ(s), highest expression level in esophagus mucosa. DR ExpressionAtlas; Q6H3X3; baseline and differential. DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IPI:UniProtKB. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IDA:UniProtKB. DR GO; GO:0002729; P:positive regulation of natural killer cell cytokine production; IDA:UniProtKB. DR GO; GO:0016032; P:viral process; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW Alternative splicing; Cell membrane; Complete proteome; KW Disulfide bond; Endoplasmic reticulum; Glycoprotein; GPI-anchor; KW Host-virus interaction; Immunity; Lipoprotein; Membrane; Polymorphism; KW Reference proteome; Secreted; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 25 {ECO:0000250|UniProtKB:Q9BZM5}. FT CHAIN 26 218 UL-16 binding protein 5. FT /FTId=PRO_0000019022. FT PROPEP 219 334 Removed in mature form. {ECO:0000255}. FT /FTId=PRO_0000429932. FT TOPO_DOM 26 223 Extracellular. {ECO:0000255}. FT TRANSMEM 224 243 Helical. {ECO:0000255}. FT TOPO_DOM 244 334 Cytoplasmic. {ECO:0000255}. FT REGION 29 117 MHC class I alpha-1 like. FT REGION 118 210 MHC class I alpha-2 like. FT LIPID 218 218 GPI-anchor amidated glycine. FT {ECO:0000305|PubMed:20304922}. FT CARBOHYD 82 82 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:19349973}. FT DISULFID 50 66 {ECO:0000250|UniProtKB:Q9BZM4}. FT DISULFID 127 190 {ECO:0000250|UniProtKB:Q9BZM4}. FT VAR_SEQ 118 154 Missing (in isoform 3). FT {ECO:0000303|PubMed:18544572}. FT /FTId=VSP_059264. FT VAR_SEQ 211 213 APP -> GTV (in isoform 2). FT {ECO:0000303|PubMed:15240696}. FT /FTId=VSP_051621. FT VAR_SEQ 214 334 Missing (in isoform 2 and isoform 3). FT {ECO:0000303|PubMed:15240696}. FT /FTId=VSP_051622. FT VARIANT 70 70 T -> R (in dbSNP:rs9397449). FT /FTId=VAR_033449. FT MUTAGEN 217 217 S->P: Reduced cell surface expression. FT {ECO:0000269|PubMed:20304922}. SQ SEQUENCE 334 AA; 37106 MW; 3F8350036951BA69 CRC64; MAAAASPAFL LRLPLLLLLS SWCRTGLADP HSLCYDITVI PKFRPGPRWC AVQGQVDEKT FLHYDCGSKT VTPVSPLGKK LNVTTAWKAQ NPVLREVVDI LTEQLLDIQL ENYIPKEPLT LQARMSCEQK AEGHGSGSWQ LSFDGQIFLL FDSENRMWTT VHPGARKMKE KWENDKDMTM SFHYISMGDC TGWLEDFLMG MDSTLEPSAG APPTMSSGTA QPRATATTLI LCCLLIMCLL ICSRHSLTQS HGHHPQSLQP PPHPPLLHPT WLLRRVLWSD SYQIAKRPLS GGHVTRVTLP IIGDDSHSLP CPLALYTINN GAARYSEPLQ VSIS // ID ULBP6_HUMAN Reviewed; 246 AA. AC Q5VY80; A3KME4; Q8TE74; DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 07-DEC-2004, sequence version 1. DT 12-SEP-2018, entry version 107. DE RecName: Full=UL16-binding protein 6 {ECO:0000303|PubMed:19658097}; DE AltName: Full=Retinoic acid early transcript 1L protein; DE Flags: Precursor; GN Name=RAET1L; Synonyms=ULBP6 {ECO:0000303|PubMed:19658097}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT THR-85. RX PubMed=11827464; DOI=10.1006/geno.2001.6673; RA Radosavljevic M., Cuillerier B., Wilson M.J., Clement O., Wicker S., RA Gilfillan S., Beck S., Trowsdale J., Bahram S.; RT "A cluster of ten novel MHC class I related genes on human chromosome RT 6q24.2-q25.3."; RL Genomics 79:114-123(2002). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-246, AND VARIANT THR-85. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP VARIANTS GLY-26; THR-85; ARG-106 AND ILE-147, FUNCTION, INTERACTION RP WITH KLRK1 AND CMV UL16, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY. RX PubMed=19658097; DOI=10.1002/eji.200939502; RA Eagle R.A., Traherne J.A., Hair J.R., Jafferji I., Trowsdale J.; RT "ULBP6/RAET1L is an additional human NKG2D ligand."; RL Eur. J. Immunol. 39:3207-3216(2009). RN [5] {ECO:0000244|PDB:4S0U} RP X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 29-203 IN COMPLEX WITH RP KLRK1, VARIANTS GLY-26; THR-85; ARG-106 AND ILE-147, CHARACTERIZATION RP OF ALLELES ULBP6*01 AND ULBP6*02, INTERACTION WITH KLRK1, AND TISSUE RP SPECIFICITY. RX PubMed=28559451; DOI=10.1126/scisignal.aai8904; RA Zuo J., Willcox C.R., Mohammed F., Davey M., Hunter S., Khan K., RA Antoun A., Katakia P., Croudace J., Inman C., Parry H., Briggs D., RA Malladi R., Willcox B.E., Moss P.; RT "A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target RT cell killing by enhancing the stability of NKG2D ligand binding."; RL Sci. Signal. 10:0-0(2017). CC -!- FUNCTION: Binds and activates the KLRK1/NKG2D receptor, mediating CC natural killer cell cytotoxicity. {ECO:0000269|PubMed:19658097, CC ECO:0000269|PubMed:28559451}. CC -!- SUBUNIT: Interacts with KLRK1/NKG2D. {ECO:0000269|PubMed:19658097, CC ECO:0000269|PubMed:28559451}. CC -!- SUBUNIT: (Microbial infection) In CMV-infected cells, interacts CC with the viral glycoprotein UL16; this interaction causes CC relocalization from the cell surface to the cytoplasm and prevents CC binding to and activation of KLRK1/NKG2D, providing CMV with an CC immune evasion mechanism. {ECO:0000269|PubMed:19658097}. CC -!- INTERACTION: CC P26718:KLRK1; NbExp=4; IntAct=EBI-16364752, EBI-458344; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19658097}; CC Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:19658097}. CC Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9BZM6}. Note=In CMV- CC infected fibroblasts, detected intracellularly. CC {ECO:0000269|PubMed:19658097}. CC -!- TISSUE SPECIFICITY: Widely expressed (PubMed:11827464). Expressed CC in trachea (PubMed:19658097). Constitutively expressed in CC peripheral blood mononuclear cells, including B-cells and natural CC killer cells, as well as CD4+ and CD8+ T-cells and monocytes. CC Tends to be up-regulated in various lymphoid malignancies, CC including chronic lymphocytic leukemia (PubMed:28559451). CC {ECO:0000269|PubMed:11827464, ECO:0000269|PubMed:19658097, CC ECO:0000269|PubMed:28559451}. CC -!- POLYMORPHISM: 4 alleles have been identified in 32 Caucasian CC individuals: ULBP6*01 (frequency 0.483), ULBP6*02 (frequency CC 0.424), ULBP6*03 (frequency 0.069) and ULBP6*04 (frequency 0.024). CC The sequence shown is that of ULBP6*03 (PubMed:19658097). Allele CC ULBP6*02 has a much higher affinity for KLRK1/NKG2D than allele CC ULBP6*01, but elicits less-efficient cytotoxicity. This high CC binding affinity and limited functional potency may depend upon CC the presence of the Leu residue at position 106 (PubMed:28559451). CC {ECO:0000269|PubMed:19658097, ECO:0000269|PubMed:28559451}. CC -!- MISCELLANEOUS: UL16-binding proteins (ULBPs) are unusual members CC of the extended MHC class I superfamily. They do not contain the CC alpha 3 domain and lack a transmembrane domain. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AY039682; AAK91503.1; -; mRNA. DR EMBL; AL355497; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC131600; AAI31601.1; -; mRNA. DR CCDS; CCDS5224.1; -. DR RefSeq; NP_570970.2; NM_130900.2. DR RefSeq; XP_011533788.1; XM_011535486.2. DR UniGene; Hs.558659; -. DR PDB; 4S0U; X-ray; 2.35 A; C=29-203. DR PDBsum; 4S0U; -. DR ProteinModelPortal; Q5VY80; -. DR SMR; Q5VY80; -. DR BioGrid; 127532; 1. DR IntAct; Q5VY80; 2. DR STRING; 9606.ENSP00000286380; -. DR iPTMnet; Q5VY80; -. DR PhosphoSitePlus; Q5VY80; -. DR BioMuta; RAET1L; -. DR DMDM; 74747619; -. DR MaxQB; Q5VY80; -. DR PaxDb; Q5VY80; -. DR PeptideAtlas; Q5VY80; -. DR PRIDE; Q5VY80; -. DR ProteomicsDB; 65623; -. DR DNASU; 154064; -. DR Ensembl; ENST00000286380; ENSP00000286380; ENSG00000155918. DR Ensembl; ENST00000367341; ENSP00000356310; ENSG00000155918. DR GeneID; 154064; -. DR KEGG; hsa:154064; -. DR UCSC; uc011eei.2; human. DR CTD; 154064; -. DR DisGeNET; 154064; -. DR EuPathDB; HostDB:ENSG00000155918.7; -. DR GeneCards; RAET1L; -. DR H-InvDB; HIX0032851; -. DR HGNC; HGNC:16798; RAET1L. DR MIM; 611047; gene. DR neXtProt; NX_Q5VY80; -. DR OpenTargets; ENSG00000155918; -. DR PharmGKB; PA134918665; -. DR eggNOG; ENOG410J4VC; Eukaryota. DR eggNOG; ENOG41113ZC; LUCA. DR GeneTree; ENSGT00390000003472; -. DR HOGENOM; HOG000070028; -. DR HOVERGEN; HBG052564; -. DR InParanoid; Q5VY80; -. DR KO; K07987; -. DR OMA; FLVHWEE; -. DR OrthoDB; EOG091G0I62; -. DR PhylomeDB; Q5VY80; -. DR TreeFam; TF341724; -. DR Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins. DR GenomeRNAi; 154064; -. DR PRO; PR:Q5VY80; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000155918; Expressed in 31 organ(s), highest expression level in esophagus mucosa. DR CleanEx; HS_RAET1L; -. DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0016032; P:viral process; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 1: Evidence at protein level; KW 3D-structure; Cell membrane; Complete proteome; Disulfide bond; KW Endoplasmic reticulum; Glycoprotein; GPI-anchor; KW Host-virus interaction; Immunity; Lipoprotein; Membrane; Polymorphism; KW Reference proteome; Signal. FT SIGNAL 1 25 {ECO:0000255}. FT CHAIN 26 218 UL16-binding protein 6. FT /FTId=PRO_0000320324. FT PROPEP 219 246 Removed in mature form. {ECO:0000250}. FT /FTId=PRO_0000320325. FT REGION 29 117 MHC class I alpha-1 like. {ECO:0000250}. FT REGION 118 210 MHC class I alpha-2 like. {ECO:0000250}. FT LIPID 218 218 GPI-anchor amidated glycine. FT {ECO:0000250}. FT CARBOHYD 68 68 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 82 82 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 50 66 {ECO:0000250}. FT DISULFID 127 190 {ECO:0000250}. FT VARIANT 26 26 R -> G (in allele ULBP6*01 and allele FT ULBP6*04; dbSNP:rs1543547). FT {ECO:0000269|PubMed:19658097, FT ECO:0000269|PubMed:28559451}. FT /FTId=VAR_039183. FT VARIANT 85 85 M -> T (in allele ULBP6*01, allele FT ULBP6*02 and allele ULBP6*04; FT dbSNP:rs912565). FT {ECO:0000269|PubMed:11827464, FT ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:19658097, FT ECO:0000269|PubMed:28559451}. FT /FTId=VAR_039184. FT VARIANT 106 106 L -> R (in allele ULBP6*01; affects FT KLRK1-binding affinity and KLRK1-mediated FT cytotoxic response; dbSNP:rs1555696). FT {ECO:0000269|PubMed:19658097, FT ECO:0000269|PubMed:28559451}. FT /FTId=VAR_039185. FT VARIANT 147 147 T -> I (in allele ULBP6*01; no effect on FT KLRK1-binding affinity; FT dbSNP:rs61730071). FT {ECO:0000269|PubMed:19658097, FT ECO:0000269|PubMed:28559451}. FT /FTId=VAR_079132. FT STRAND 31 39 {ECO:0000244|PDB:4S0U}. FT HELIX 41 43 {ECO:0000244|PDB:4S0U}. FT HELIX 47 49 {ECO:0000244|PDB:4S0U}. FT STRAND 50 56 {ECO:0000244|PDB:4S0U}. FT STRAND 59 65 {ECO:0000244|PDB:4S0U}. FT HELIX 77 81 {ECO:0000244|PDB:4S0U}. FT HELIX 86 106 {ECO:0000244|PDB:4S0U}. FT STRAND 121 129 {ECO:0000244|PDB:4S0U}. FT STRAND 131 133 {ECO:0000244|PDB:4S0U}. FT STRAND 135 143 {ECO:0000244|PDB:4S0U}. FT STRAND 146 152 {ECO:0000244|PDB:4S0U}. FT TURN 153 156 {ECO:0000244|PDB:4S0U}. FT STRAND 157 163 {ECO:0000244|PDB:4S0U}. FT HELIX 166 174 {ECO:0000244|PDB:4S0U}. FT HELIX 176 187 {ECO:0000244|PDB:4S0U}. FT HELIX 189 202 {ECO:0000244|PDB:4S0U}. SQ SEQUENCE 246 AA; 27509 MW; 5FBBEA2289E32690 CRC64; MAAAAIPALL LCLPLLFLLF GWSRARRDDP HSLCYDITVI PKFRPGPRWC AVQGQVDEKT FLHYDCGNKT VTPVSPLGKK LNVTMAWKAQ NPVLREVVDI LTEQLLDIQL ENYTPKEPLT LQARMSCEQK AEGHSSGSWQ FSIDGQTFLL FDSEKRMWTT VHPGARKMKE KWENDKDVAM SFHYISMGDC IGWLEDFLMG MDSTLEPSAG APLAMSSGTT QLRATATTLI LCCLLIILPC FILPGI // ID S4SR81_CHLSB Unreviewed; 290 AA. AC S4SR81; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 27. DE SubName: Full=MHC class IE protein {ECO:0000313|EMBL:AFP92174.1}; DE Flags: Fragment; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|EMBL:AFP92174.1}; RN [1] {ECO:0000313|EMBL:AFP92174.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:AFP92174.1}; RX PubMed=24676686; DOI=10.1007/s00251-014-0770-9; RA Aarnink A., Jacquelin B., Dauba A., Hebrard S., Moureaux E., RA Muller-Trutwin M., Blancher A.; RT "MHC polymorphism in Caribbean African green monkeys."; RL Immunogenetics 66:353-360(2014). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KA650597; AFP92174.1; -; mRNA. DR OrthoDB; EOG091G09OH; -. DR ExpressionAtlas; S4SR81; baseline. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 290 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004532948. FT DOMAIN 203 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 290 290 {ECO:0000313|EMBL:AFP92174.1}. SQ SEQUENCE 290 AA; 33101 MW; 96D19E06555FCC51 CRC64; MALGTLLLLL SALTKTWAGS HSLKYFHTSV SRPGRGEPRF ISVGYVDDTQ FVRFDSDAAS PRMQPRAPWV EQEGPEYWDQ ETRSARDTAQ TFRVNLNTLR GYYNQSEAGS HTLQWMHGCD LGPDGRFLRG YEQFAYDGKD YLTLNEDLRS WSAVDTAAQI SEQKSNDGSE AEHQRAYLED TCVEWLRRYL ENGKETLQRS EPPKTHVTHH PVSDHEATLR CWALGFYPAE ITVTWQRDGE DQTQDMELVE TRPAGDGTFQ KWAAVVVPSG EEQRYTCHVQ HEGLPEPLTL // ID S7MEI7_MYOBR Unreviewed; 288 AA. AC S7MEI7; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 28-FEB-2018, entry version 26. DE SubName: Full=Popy Class I histocompatibility antigen, A-1 alpha chain {ECO:0000313|EMBL:EPQ02096.1}; GN ORFNames=D623_10003406 {ECO:0000313|EMBL:EPQ02096.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ02096.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE161170; EPQ02096.1; -; Genomic_DNA. DR ProteinModelPortal; S7MEI7; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 236 257 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 139 227 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 288 AA; 31843 MW; 91F0D4B23BB96679 CRC64; MQQPWVERVY PGYWDWHTQV NKETAQIYRV GLQNLRGYYN QSEDGPHTFQ RMSGCDVGPD GLLLRGYEQY AYDGADYIAL NEDLTSWAAA DMAAQITKRK WEATGEAEKK RSYLEGLCVE SLLMYLDKGK ETLQRADPPK AHVTRHPVSA REVTLRCWAL GFYPADISLT WQRDGEDQTQ DMELVETRPA GDGTFQKWAA LGVPPGEEQR YTCHVQHEGL PEPLTLRWEP PSQTSIIITG IAGGLVLLGA VAGAVLWGRR RSGGNGGSYA QAASSGGAQG PDVPLSAL // ID S7MJV1_MYOBR Unreviewed; 255 AA. AC S7MJV1; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 28-FEB-2018, entry version 26. DE SubName: Full=Patr class I histocompatibility antigen, A-126 alpha chain {ECO:0000313|EMBL:EPQ03755.1}; GN ORFNames=D623_10007277 {ECO:0000313|EMBL:EPQ03755.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ03755.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE161426; EPQ03755.1; -; Genomic_DNA. DR ProteinModelPortal; S7MJV1; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 183 207 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 88 176 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 255 AA; 28484 MW; B5552B66E199A8E5 CRC64; MYGCEMGSDG SFLRGYDQFA YDGADYIALN EDLRSWTAAN EAAQLSRRRY EAVDEAEVQR NYLERVCMEW LRRYLEKGKD ILQRAEPPKA HVTHHPVSAR EVTLRCWALG FYPADISLTW QRDGEEQIQD LELVETRPAG DGTFQKWAAV GVPPGEEQRY TCHVHHEGLP EPLTLRWEPP PQIFIFIIMG IAGGLVLLGA VAGAVMWGRR RSGGKGGSYA QTARGDSSWG SDVLLKASKV TTREQTLNAG AAELQ // ID S7MM68_MYOBR Unreviewed; 758 AA. AC S7MM68; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 12-SEP-2018, entry version 32. DE SubName: Full=RLA class I histocompatibility antigen, alpha chain 11/11 {ECO:0000313|EMBL:EPQ05296.1}; GN ORFNames=D623_10002379 {ECO:0000313|EMBL:EPQ05296.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ05296.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE- CC ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE161786; EPQ05296.1; -; Genomic_DNA. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro. DR CDD; cd00021; BBOX; 1. DR CDD; cd00086; homeodomain; 1. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR000315; Znf_B-box. DR InterPro; IPR001841; Znf_RING. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR InterPro; IPR017907; Znf_RING_CS. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00046; Homeobox; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF00643; zf-B_box; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00336; BBOX; 1. DR SMART; SM00389; HOX; 1. DR SMART; SM00407; IGc1; 1. DR SMART; SM00184; RING; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. DR PROSITE; PS50119; ZF_BBOX; 1. DR PROSITE; PS00518; ZF_RING_1; 1. DR PROSITE; PS50089; ZF_RING_2; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108, KW ECO:0000256|RuleBase:RU000682}; KW Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108, KW ECO:0000256|RuleBase:RU000682}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175, KW ECO:0000256|SAAS:SAAS00139444}; KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108, KW ECO:0000256|RuleBase:RU000682}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175, KW ECO:0000256|SAAS:SAAS00139444}; KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175, KW ECO:0000256|SAAS:SAAS00139444}. FT TRANSMEM 495 516 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 66 126 Homeobox. {ECO:0000259|PROSITE:PS50071}. FT DOMAIN 398 486 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 577 603 RING-type. {ECO:0000259|PROSITE:PS50089}. FT DOMAIN 704 745 B box-type. FT {ECO:0000259|PROSITE:PS50119}. FT DNA_BIND 68 127 Homeobox. {ECO:0000256|PROSITE- FT ProRule:PRU00108}. SQ SEQUENCE 758 AA; 85539 MW; BE578C0924CCA297 CRC64; MEVEGRREQG KPRKGRVCSS LWLESCPAAR TQTSTVDLSA QPCRSLSGVG VGTPRLSPQG QRGHLHSRRR HRTTFSPAQL EQLESAFGRN QYPDIWARED LARDTGLSEA RIQVWFQNRR AKQRKQERSL LQPLAHLSPA TFSGFLPESP ACPYSYSTPS PPGTCFPHPC NYALPSQPST ESPWGLPVVA DGPAPLAKAV MAELAGLKLE HKPWPGGTHS LRYHYLALSE PGPGLPQFLA VGYVNDQPFI RYDSRVGRAE PQAPWIAPVD PRYWEMETQK QKAWAEVQQV EMWTVMGYYN QSGGTHSAQR MFGCEIQEDS RSSSFWQFGF DGRDHLSLDL ETLSWVSAEP MAVRTKRWWE SERCYAEYDK AYLEGLCLAS LRRYLELGGP SLTRREPPTV QVTRHTIQGR GTTLRCWARG FYPQEISLSW WLGEEELGLE TEHMETRPSG DGTYQTWAAV WVQAGEEAGY TCRVQHSGLN HTLTVAWEPP PPQEFVAVVT CAILLVLMLV VGVVIFTRTR PREERREEEE EEEEQEESGV GHSVPLLDAS TCRRRIEMAG HRPARNLVQT LQEEAVCAIC LDYFTDPVSI GCGHNFCRGC VTQLWGKDDE DQAVGAMGGW DHSIREVSYQ QSAGELFRDP EEGPWVGGGG IRNWDNRDDA WVPAEEEEEG DYYRIDIYEE EALANMVQVI RHLRPGPDSG SLGGEHGVCP KHQEALKLFC EVDQEAICVV CRESRSHKQH SVVPLEEVEQ EYKVRGLH // ID S7N369_MYOBR Unreviewed; 235 AA. AC S7N369; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 19. DE SubName: Full=Class I histocompatibility antigen, Gogo-B*0103 alpha chain {ECO:0000313|EMBL:EPQ11459.1}; GN ORFNames=D623_10000412 {ECO:0000313|EMBL:EPQ11459.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ11459.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE163283; EPQ11459.1; -; Genomic_DNA. DR ProteinModelPortal; S7N369; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}. FT DOMAIN 124 212 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 235 AA; 26342 MW; 6929EFDE97404A14 CRC64; MSTRNAKAYA QDFRASLQIA LGYYNQSQDG SHTLQGMRGC DMGPDGRLLR GYFQSAYDGT DYIALNEDLR SWTAANTAAQ ITRRKWEEAG EAEGIRSALE VNCLEWLRRF LALGKEVLQR ADPPKTHVTH HPISDREVTL RCWALGFYPA DISLSWQRDG EEQTQDTEFV ETRPAGDGTF QKWAALVVPR GEEQRYTCHV QHEGLPEPLT LRWGGKGGSY AQAASEYGGV TPDIL // ID S7N3B8_MYOBR Unreviewed; 232 AA. AC S7N3B8; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 21. DE SubName: Full=Patr class I histocompatibility antigen, A-126 alpha chain {ECO:0000313|EMBL:EPQ11534.1}; GN ORFNames=D623_10000797 {ECO:0000313|EMBL:EPQ11534.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ11534.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE163323; EPQ11534.1; -; Genomic_DNA. DR ProteinModelPortal; S7N3B8; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 184 210 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 88 176 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 232 AA; 26090 MW; B7EA75AAD4E1699E CRC64; MIGCQVGPDG RLLRGYLQYA YDGSDYIALN EDLTSWTTAD MAAQITLRNW EAVGGAELVR SYLEGECMEW LQIHLEKGKE TLQRTDPPKA HVTHHPVSER EVTLRCWALG FYPADISLTW QRDGEDQTQD MELVETRPAG DGTFQKWAAV GVPPGEEQRY TCHVEHEGLP EPLTLRWEPP SHTFFIIIII VGFAGVLVLL GAVAAAVMWW RRRSGGQGWG LSVLSPWGFK PR // ID S7N9R9_MYOBR Unreviewed; 170 AA. AC S7N9R9; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=Patr class I histocompatibility antigen, A-126 alpha chain {ECO:0000313|EMBL:EPQ13826.1}; GN ORFNames=D623_10001945 {ECO:0000313|EMBL:EPQ13826.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ13826.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE163794; EPQ13826.1; -; Genomic_DNA. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 140 164 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 48 84 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 170 AA; 19051 MW; 406B921FFD266F14 CRC64; MAAQITKRKW EAAGVAEGWR SYLEGTCKKW LRIHLEKGNE TLQRADPPKA HLTRHPVSAQ EVTLRCWALG FYPADISLTW QRDGEDQTQD MELVETRPAG DGTFQKWAAV GVPPGEEQRV QHEGLPEPLT LRWEPPSHTF IFIIMGIAGG LVLLGAVAGA VMWWRRRSGG // ID S7NF55_MYOBR Unreviewed; 328 AA. AC S7NF55; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 21. DE SubName: Full=Patr class I histocompatibility antigen, A-126 alpha chain {ECO:0000313|EMBL:EPQ16039.1}; GN ORFNames=D623_10000991 {ECO:0000313|EMBL:EPQ16039.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ16039.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE164203; EPQ16039.1; -; Genomic_DNA. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 328 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004554572. FT TRANSMEM 283 307 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 183 271 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 328 AA; 37609 MW; 9CEEEE7578DEE8B7 CRC64; MRVMRPPTLL LLWGALALTQ TWADPHSLRY FYTAASRPGH RRPRFVIVGY MDDTQFERFD SDSEGPRAEP RAPWMEEEEP GYWDQSTRNA RDSAQTFRLN LQNLRDYYNQ SLDVRLRRNR LHRPERGPAL LDRGQHRCSD HPRKWEEAGE TEERRLYLQD DCLELLHRVL AMGKEVLQRA DPPKTHVTHH PISDREVTLR CWALGFYPAD ISLSWQRDGE EQTQDMELVE TRPAGDGTFQ KWAALVVPRG EEQRYTCHVQ HEGLPEPLTL RWEPPPQATI PPVGLVVGLV ILGAVLTGAV VTGAVMWRRK RSGGKGGSYA QAASEYGG // ID S7NIS2_MYOBR Unreviewed; 345 AA. AC S7NIS2; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 21. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:EPQ16415.1}; GN ORFNames=D623_10022801 {ECO:0000313|EMBL:EPQ16415.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ16415.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE164257; EPQ16415.1; -; Genomic_DNA. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 304 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 345 AA; 39954 MW; 6BFF383F691CAC9B CRC64; MSQRLWMRTP GTWIMVDVKQ SQSSVKGTHS LRYFRLGISE PGHGIPEFLS VGYVDSHPIT TYDSVSRLKE PRAPWMAEHL APDHWERYTQ LLRGWQQTFK VELERLQRHY NHSGFHTYQR MIGCELLEDG STTGFLQYAY DGQDFLIFDK DTLSWTAVDN VAHITKRAWE ANWHELQYQK NWLEEECIAW LKRFLEYGKD TLQRTEPPLV KVSRKETFPG ITTLVCRAYG FYPPEISMIW MKNGEEMIQE MDYGGVLPSG DGTYQTWVSV EMDSESSDLY SCHVEHCDVQ MVLQVPQGSE TTLLVIKAVS GSIVLTMVLA GIGFLARRRR PQEKNEVIYL PAPDQ // ID S7NLJ9_MYOBR Unreviewed; 184 AA. AC S7NLJ9; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 21. DE SubName: Full=HLA class I histocompatibility antigen, A-23 alpha chain {ECO:0000313|EMBL:EPQ18389.1}; GN ORFNames=D623_10001511 {ECO:0000313|EMBL:EPQ18389.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ18389.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE164525; EPQ18389.1; -; Genomic_DNA. DR ProteinModelPortal; S7NLJ9; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}. FT DOMAIN 83 181 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 184 AA; 20918 MW; EAA7BE46537CEAE8 CRC64; MTGCDVGSDG RLLRGYSQYD YLALNQDLTS WTAAHMAAHM TWRKFVFAPN PDRWKDNLEI RCVQGLHVYL ENGKEMLRRA DPPKAHVTHH PVSAHEVTLR CWALGFYPAD ISLTWQRDGE DQTQDMELVE TRPAGDGTFQ KWAAVGVPPG EEQRYTCHVQ HEGLPFPQLE KEGAMLRLPV SMEG // ID S7NLU9_MYOBR Unreviewed; 99 AA. AC S7NLU9; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=RLA class I histocompatibility antigen, alpha chain 11/11 {ECO:0000313|EMBL:EPQ18391.1}; GN ORFNames=D623_10001515 {ECO:0000313|EMBL:EPQ18391.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ18391.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE164525; EPQ18391.1; -; Genomic_DNA. DR ProteinModelPortal; S7NLU9; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}. FT DOMAIN 1 42 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 99 AA; 11055 MW; 5BA2334789F6DA05 CRC64; MAAQNTQRKW EAAGVAERER RFLEGECVKW LRTHLEKGKE TLQRAGTRGP GAAPSPRGWG SFKETGQGFS VRHPSLDQGG NPHGCQIRYQ RDPPSLRNS // ID S7NNW8_MYOBR Unreviewed; 679 AA. AC S7NNW8; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 28-FEB-2018, entry version 23. DE SubName: Full=Patr class I histocompatibility antigen, A-126 alpha chain {ECO:0000313|EMBL:EPQ18390.1}; GN ORFNames=D623_10001514 {ECO:0000313|EMBL:EPQ18390.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ18390.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE164525; EPQ18390.1; -; Genomic_DNA. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 3. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 3. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 679 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004554813. FT TRANSMEM 249 274 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 570 594 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 479 562 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 679 AA; 76236 MW; 1978D8F4DB8E72F1 CRC64; MRVLRPPTLL LLLSGALVLT PSWAGPHSLR YFDTIVSRPG RGEPRFISVG YVDDTQFVRF DSDAPNARAE PRAQWMQLPW VEREDPQYWD RNTQINQETA QASRGSLQTL RGYYNQSEDA AQITRRKWEA AGVAEHYRIY LEDTCRKWLL IYLEKGKETL QRTGTRGPGA APSPRGWGSY KETEQGVSVR HPSLGQRETP LDVRSVTHQR SPWALQELWE SQGPSLSGLV RCPHPLCLRP DPSFSESRGL HIIIMGIAGV LVLLGAVAGA VMWWRRRSGG KGGSYSQAAS PHSLRYFYTS MSRPGRGEPR YLEVGYVDDT QFVRFDSDAP NPRMEPRAPW MQQPWVEQER PGYWEEETLK AQGQAQVFRL GLQTLRGYYN QSEDGSHTIQ RIIGCEMGPD GRLLRGYRQD AYDGADYIAL NENLTSWTAA DMVAQITQRK WEAAGEAQCM RSYLEGTCIE WLRIYLDKGK ETLQRADPPK AHVTHHPVSA REVTLRCWAL GFYPADISLT WQRDGEDQTQ DMELVETRPA GDGTFQKWAA VGVQRYTCHV KHEGLPEPLT LRWEPPSQTF IFIIIMGIAG GLVLLGAVAG AVMWGRRRLG GEGVGGSDSA QGSDVSLSAS KGETLQRGGV GRGEDWVVGS LWDTVSMKWA LRMSPVTATD LNVFMMLVLH SVRQLPCGD // ID S7NQ24_MYOBR Unreviewed; 286 AA. AC S7NQ24; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 28-FEB-2018, entry version 15. DE SubName: Full=Patr class I histocompatibility antigen, A-126 alpha chain {ECO:0000313|EMBL:EPQ19341.1}; GN ORFNames=D623_10001002 {ECO:0000313|EMBL:EPQ19341.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ19341.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE164655; EPQ19341.1; -; Genomic_DNA. DR ProteinModelPortal; S7NQ24; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 286 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004554837. FT TRANSMEM 218 238 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 122 210 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 286 AA; 32569 MW; B6CCFACACF521AF5 CRC64; MRVVRSPTLL LLLSGALVLT PSWAGPHSLR YFYTSMSRPG RGEPRYLEVG YVDDTQFVRF DSDAPNPRME PRAPWMQQPW VEREDPGYWD RHTEMAKGHA QLFRIYLKTA LGYYNQSEDD PPKAHVTHHP ISAREVTLRC WALGFYPADI SLTWQRDRED QTQDMELVET RPAGDGTFQK WVAVEVPPGE EQTHTCHVQH EGLPEPLTLK WEPPSHTFII IMGIAGGLVL LGAVAGAVKW RRRRPVEPCP TRTCGHWSSD ITEALSVLMQ RISRTMDSEA FLGLVA // ID S7NRH8_MYOBR Unreviewed; 128 AA. AC S7NRH8; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Patr class I histocompatibility antigen, B-2 alpha chain {ECO:0000313|EMBL:EPQ19340.1}; GN ORFNames=D623_10001001 {ECO:0000313|EMBL:EPQ19340.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ19340.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE164655; EPQ19340.1; -; Genomic_DNA. DR ProteinModelPortal; S7NRH8; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}. FT DOMAIN 1 82 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 128 AA; 14131 MW; C4D0DDA0B5777042 CRC64; MYGCEVGPDG RLLRGYEQYA YDGADYIALN EDLTSWTAAD MAAQITKRKW EAAHWAERMR SYLEGLCVES LLMYLEKGKE SLQRAGTVRP GAIPSPSGWG SYKETGQGVS VRHPSLGSGR EPPGCQVR // ID S7NUP4_MYOBR Unreviewed; 151 AA. AC S7NUP4; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Popy Class I histocompatibility antigen, A-1 alpha chain {ECO:0000313|EMBL:EPQ20820.1}; GN ORFNames=D623_10000071 {ECO:0000313|EMBL:EPQ20820.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ20820.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE326505; EPQ20820.1; -; Genomic_DNA. DR ProteinModelPortal; S7NUP4; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}. FT DOMAIN 1 82 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 151 AA; 16347 MW; 1053A7EDA5B37767 CRC64; MVGCDLGPDG RLLRGHWQYA YDGADYITLN EDLTSWTAAD MAAQITRRKW EAAGEAEHAK SYLEGLCVES LLMYLAKGKE ILQRAGTRGP GAAPSPRGWG SYKETGQGVS VRHPSLGQGG SPLDVQVRYQ RDSPSQGQLA VQALLGCREN P // ID S7NZF6_MYOBR Unreviewed; 295 AA. AC S7NZF6; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 20. DE SubName: Full=Class I histocompatibility antigen, Gogo-B*0103 alpha chain {ECO:0000313|EMBL:EPQ03173.1}; GN ORFNames=D623_10000844 {ECO:0000313|EMBL:EPQ03173.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ03173.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE161333; EPQ03173.1; -; Genomic_DNA. DR ProteinModelPortal; S7NZF6; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 2. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}. FT DOMAIN 88 178 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 295 AA; 33239 MW; 766B0C2959107FEB CRC64; MLGCDMGPDG RLLRGYYQSA YDGTDYIALN EDLRSWTAAD TAAQITQRKW EEAGEAERFR NILEGRCLEL LHRVLEMGKE VLQRADPPKT HVTHHPISDR EVTLRCWALG FYPADISLSW QRDGEEQTQD TEFVETRPAG DGTFQKWAAL VVPRGEEQRY TCHTSAPNGA GRRVAGVSPS LRPAGPHSLR HFLTAESRPG HRKPRFVVVS YVDDTQFVRF DSDAASPRME PRAPWMEQEE PGYWDVNTRN AEVAAQSFRL NLDILRGYYN QSRDGEPRGL GPVTTRIPTA GPGSP // ID S7P635_MYOBR Unreviewed; 141 AA. AC S7P635; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Class I histocompatibility antigen, Gogo-C*0203 alpha chain {ECO:0000313|EMBL:EPQ03172.1}; GN ORFNames=D623_10000843 {ECO:0000313|EMBL:EPQ03172.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ03172.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE161333; EPQ03172.1; -; Genomic_DNA. DR ProteinModelPortal; S7P635; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 141 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004543541. FT DOMAIN 26 120 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 141 AA; 15707 MW; CBC35548660E2347 CRC64; MPVMGSPALL LLLCGALALT QTWAGPHSLR YFYTIVSRPG RGEPRFFAVG YVDDTQFVRF DSDAASPRAE PRAPWMQQPW VEREDSGYWD RETQNLKGHA QTFRVGLKIL RGYYNQSRDG EPRGPGPVTA PIPTDGPGSP E // ID S7P7B0_MYOBR Unreviewed; 118 AA. AC S7P7B0; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=HLA class I histocompatibility antigen, B-14 alpha chain {ECO:0000313|EMBL:EPQ06008.1}; GN ORFNames=D623_10001319 {ECO:0000313|EMBL:EPQ06008.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ06008.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE161940; EPQ06008.1; -; Genomic_DNA. DR ProteinModelPortal; S7P7B0; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 92 115 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 82 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 118 AA; 13364 MW; 71984D2E67D07775 CRC64; MYGCDLGPDG SLLRGYLQYA YDGADYIALN EDLTSWTAAD MAAQISKMKF EQGGEAEYQR SYLEGTCMKF LRIHLEKGKK TLQRAEPPSH TFYIIMGSAV SLVVLVAMAG VVRWWRRR // ID S7PDL6_MYOBR Unreviewed; 246 AA. AC S7PDL6; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 20. DE SubName: Full=Popy Class I histocompatibility antigen, A-1 alpha chain {ECO:0000313|EMBL:EPQ06007.1}; GN ORFNames=D623_10001315 {ECO:0000313|EMBL:EPQ06007.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ06007.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE161940; EPQ06007.1; -; Genomic_DNA. DR ProteinModelPortal; S7PDL6; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 184 208 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 88 176 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 246 AA; 27643 MW; 50D6141D960D052E CRC64; MYGCDLGPDG RLLRGYRQYA YDGVDYLALN EDLTSWTAAD MAAQITKRKW EAAGHAEHHR NYLEGLCVES LLIYLEKGKE TLQRADPPKA HVTHHPVSAH EVTLRCWALG FYPADISLTW QRDGEDQTQD MELVETRPAG DGTFQKWAAV GVPPGEEQRY TCYVQHEGLP EPLTLRWDPP SQTFIIIIIM DIAGVLVLLV IVFATLIWGR RRSGGQEWGL SVRPTGGSSP GRRVSRLIHG KHHPHA // ID S7PU68_MYOBR Unreviewed; 245 AA. AC S7PU68; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 20-DEC-2017, entry version 25. DE SubName: Full=Patr class I histocompatibility antigen, A-126 alpha chain {ECO:0000313|EMBL:EPQ12082.1}; GN ORFNames=D623_10001340 {ECO:0000313|EMBL:EPQ12082.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ12082.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE163431; EPQ12082.1; -; Genomic_DNA. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 190 215 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 88 176 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT COILED 53 73 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 245 AA; 27434 MW; 89924E3C2C2414AB CRC64; MLGCDLGPDG RLLRGYHQYA YDGTDYIALN EDLRSWTAAD TAAQITRRKW EASDEAEERR HYLEEECTEL LRRFLEMGKE ALQRTDPPKT HVTHHPISDR EVTLRCWALG FYPADISLSW QRDGEEQTQD MELVETRPAG DGTFQKWAAL VVPPGEEQRY TCHVQHEGLP EPLTLRWEPP PRATIPAVGL VGLVILGAVL NIAVVTGAVV TGAVMMRRRK RLGGKGGSYH THAASEYGGV TPETM // ID S7PYZ1_MYOBR Unreviewed; 289 AA. AC S7PYZ1; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 28-FEB-2018, entry version 24. DE SubName: Full=Patr class I histocompatibility antigen, A-2 alpha chain {ECO:0000313|EMBL:EPQ13827.1}; GN ORFNames=D623_10001949 {ECO:0000313|EMBL:EPQ13827.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ13827.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE163794; EPQ13827.1; -; Genomic_DNA. DR ProteinModelPortal; S7PYZ1; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 176 199 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 80 168 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 289 AA; 31705 MW; BC0B892C4E6F9C95 CRC64; MGAYSAVTVS GPMMAPEYIA LNKDLTSWTA ADMAAQITRR KWEAAGVAER ERRFLEGTCM EWLLIYLEKG METLQRADSP KAHVTHHPIS AREVTLRCWA LGFYPADISL TWQCDGEDQT QDRELVETRP AGDGTFQKWA AVGVPSGEEQ RYTCHVQHEG LPEPLTLRWE PPSQTFIFII MGIVGGLVLL GAMAGAVMWG RRRSGGSGRS YTQAASSDRG QGSDVSLSAS KGATLLSRGV GRGEDWVVGS LWDTVSMKWP LIMAPVTATD LNVFMMLVLH SVRQLPCGD // ID S7Q390_MYOBR Unreviewed; 231 AA. AC S7Q390; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 28-FEB-2018, entry version 25. DE SubName: Full=Patr class I histocompatibility antigen, A-2 alpha chain {ECO:0000313|EMBL:EPQ17803.1}; GN ORFNames=D623_10002538 {ECO:0000313|EMBL:EPQ17803.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ17803.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE164410; EPQ17803.1; -; Genomic_DNA. DR ProteinModelPortal; S7Q390; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 178 201 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 83 171 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 231 AA; 25779 MW; A29F6272946C4F7F CRC64; MGPDGRLLRG YSQWAYDGAD YIALNEDLRS WTAADMAAQI TKSKWEATRF HERRSNYLEG ECLQWLRLYL EKGKETLLRA DPPKAHVTHH PVSDSEVTLR CWALGFYPAD ITLTWQRDGE DQTQDMELVE TRPAGDGTFQ KWAAVGVPPG QEQRYTCHVQ HEGLPEPLTL RWEPPQTFIF IIMGIAGGLV LLGAVAGAVM WKRRRSGGKG GSYAQAASSD NPQGSDVSLG F // ID S7Q4U4_MYOBR Unreviewed; 329 AA. AC S7Q4U4; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 28-FEB-2018, entry version 22. DE SubName: Full=Patr class I histocompatibility antigen, A-126 alpha chain {ECO:0000313|EMBL:EPQ18388.1}; GN ORFNames=D623_10001510 {ECO:0000313|EMBL:EPQ18388.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ18388.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE164525; EPQ18388.1; -; Genomic_DNA. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 2. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 205 228 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 269 286 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 109 197 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 329 AA; 37795 MW; CB883E36597F3E85 CRC64; MRGCYMGPDG RLLRGYYQYA YDGADYIALN EDLTSWTAAD MAAQITKRNW ETKSKWEAIN FAHKWEMKHK WEWASFAEVM RFYLEDTCME WLRNHLEKGK ETLQRADPPK AHVTHHLVSA SEVTLRCWAL GFYPADISLT WKRDGEDQTQ DMELVETRPA GDGTFQKWAA VGVPPGEEQR YTCHVQHEGL SEPLTLRWEP PSHTFVISIM GITGGLVLLG AVAGAVMWGR RRSEQPISIR AGHCYNLSWT RPDSDGPTMP RMRVLTPPTL LLLLSGALAL TPSWAVDDIE FVRFDNDAAN PRLEPRVPWM QQPWVYSNYW GWETGIVKY // ID S7Q9W1_MYOBR Unreviewed; 296 AA. AC S7Q9W1; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 28-FEB-2018, entry version 25. DE SubName: Full=Popy Class I histocompatibility antigen, A-1 alpha chain {ECO:0000313|EMBL:EPQ17802.1}; GN ORFNames=D623_10002537 {ECO:0000313|EMBL:EPQ17802.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ17802.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE164410; EPQ17802.1; -; Genomic_DNA. DR ProteinModelPortal; S7Q9W1; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 184 206 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 88 176 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 296 AA; 32525 MW; E7B52458052501A4 CRC64; MYGCKVGPDG RLLRGYSQWA YDGADYLALN EDLTSWNAAN MAAQVTQRKW EAEGWAKRVR SDLEGLCVES LLMCLEKEKE TLQRADPPKA HVTHHPVSAS EVTLRCWALG FYPADISLTW QRDGEDQTQD MELVETRPAG DGTFQKWAAV GVPPGEEQRY TCHVQHEGLP EPLTLRWEPP SHTFIIIMGI AGCLVLLGAV AGAVMWGRRR SGGKGGSYAQ AASSDSAQGS DVSFSASRGE TLSWGGVGRG EDWVVGCQWD TVSRKWTVIM SPVTATDLNL LIMIVFYSVR QLPCGD // ID S7QB59_MYOBR Unreviewed; 232 AA. AC S7QB59; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 20. DE SubName: Full=Patr class I histocompatibility antigen, A-2 alpha chain {ECO:0000313|EMBL:EPQ20778.1}; GN ORFNames=D623_10000445 {ECO:0000313|EMBL:EPQ20778.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ20778.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KE320669; EPQ20778.1; -; Genomic_DNA. DR ProteinModelPortal; S7QB59; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 180 205 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 84 172 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 232 AA; 25617 MW; E185ADF2E1A70A40 CRC64; MYGCDVGPDG RLLRGYRQDA YDGADYIALN EDLTSWTAAD MAAQITKRKW EAAGQAEYLE GECMPWLRLY LEKGKETLQR TDPPKAHVTH PVSSDHEVTL RCWALGFYPA DISLTWQRDG EDQTQDMELV ETRPAGDGTF QKWAAVGVPP GEEQRYTCHV QHEGLPEPLT LRWEPPSPTF IFVIIIMGIA GGLVLLGAVA GALMWGRRRS GGKGGSYAQA ASEYGRGTPE SL // ID S9WCF5_CAMFR Unreviewed; 111 AA. AC S9WCF5; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EPY75782.1}; GN ORFNames=CB1_001562001 {ECO:0000313|EMBL:EPY75782.1}; OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Tylopoda; OC Camelidae; Camelus. OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY75782.1, ECO:0000313|Proteomes:UP000030684}; RN [1] {ECO:0000313|EMBL:EPY75782.1, ECO:0000313|Proteomes:UP000030684} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684}; RX PubMed=23149746; RG Bactrian Camels Genome Sequencing and Analysis Consortium; RA Jirimutu null, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., RA Wang L., Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., RA Zhang W., Batmunkh M., Ts B., Narenbatu null, Unierhu null, RA Bat-Ireedui S., Gao H., Baysgalan B., Li Q., Jia Z., RA Turigenbayila null, Subudenggerile null, Narenmanduhu null, Wang Z., RA Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt null, Erdemt null, RA Altansha null, Altansukh null, Liu T., Cao M., Aruuntsever null, RA Bayart null, Hosblig null, He F., Zha-ti A., Zheng G., Qiu F., Sun Z., RA Zhao L., Zhao W., Liu B., Li C., Chen Y., Tang X., Guo C., Liu W., RA Ming L., Temuulen null, Cui A., Li Y., Gao J., Li J., Wurentaodi null, RA Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T., Bayaer T., RA Li Y., Meng H.; RT "Genome sequences of wild and domestic bactrian camels."; RL Nat. Commun. 3:1202-1202(2012). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB017723; EPY75782.1; -; Genomic_DNA. DR ProteinModelPortal; S9WCF5; -. DR Proteomes; UP000030684; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000030684}; KW Reference proteome {ECO:0000313|Proteomes:UP000030684}. FT DOMAIN 37 110 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 111 AA; 12829 MW; 21A0304955960F29 CRC64; MDQSSLCFSK TLMRIWGSRA LLLQLSGALA LTETWAGSHS MRYFETGVSR PGLGEPWYVE VGYVDDTQFV RFDSDAPNPR MEPRARWVEQ EGPAYWDRET RRSKENAHIF P // ID S9WCG4_CAMFR Unreviewed; 409 AA. AC S9WCG4; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 21. DE SubName: Full=Major histocompatibility complex, class I {ECO:0000313|EMBL:EPY75792.1}; GN ORFNames=CB1_001562002 {ECO:0000313|EMBL:EPY75792.1}; OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Tylopoda; OC Camelidae; Camelus. OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY75792.1, ECO:0000313|Proteomes:UP000030684}; RN [1] {ECO:0000313|EMBL:EPY75792.1, ECO:0000313|Proteomes:UP000030684} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684}; RX PubMed=23149746; RG Bactrian Camels Genome Sequencing and Analysis Consortium; RA Jirimutu null, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., RA Wang L., Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., RA Zhang W., Batmunkh M., Ts B., Narenbatu null, Unierhu null, RA Bat-Ireedui S., Gao H., Baysgalan B., Li Q., Jia Z., RA Turigenbayila null, Subudenggerile null, Narenmanduhu null, Wang Z., RA Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt null, Erdemt null, RA Altansha null, Altansukh null, Liu T., Cao M., Aruuntsever null, RA Bayart null, Hosblig null, He F., Zha-ti A., Zheng G., Qiu F., Sun Z., RA Zhao L., Zhao W., Liu B., Li C., Chen Y., Tang X., Guo C., Liu W., RA Ming L., Temuulen null, Cui A., Li Y., Gao J., Li J., Wurentaodi null, RA Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T., Bayaer T., RA Li Y., Meng H.; RT "Genome sequences of wild and domestic bactrian camels."; RL Nat. Commun. 3:1202-1202(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB017723; EPY75792.1; -; Genomic_DNA. DR Proteomes; UP000030684; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000030684}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000030684}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 362 384 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 262 352 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 409 AA; 46720 MW; 96C55050B9EA62E0 CRC64; MRVLLLLRFQ GIPKAILAKQ KWSWLSWFWV PGPGCARGSR GQSVTADGML WALALLYLFL SLLPETRARS HSLQYFYSAM SEPVLGKPAF TALGFVDDQP FIRYDSKEMK AKSCVQWLTE EPSYFDDETK IFNSRMKIFH LNLRNLQQYY NKTMEDGLNT ALPQKQAGPH TLQFAYGCEL HEDGRTTVHW QYGYDGDDYL SLDTDSLQYT AATFIAQYTK QKWEASGNFI ERDKNYLEKE CVLWLRRYLK FGGESLNRTE PPRTHMTHHP ISDRASDRKV TLRCWALGFY PAEISLTWQR DGEDQAQDTE LVETRPAGDG TFQKWAALVV SPGEEQRYTC HVQHEGLQEP LSLRWEPPPQ PIMGIIFGLV LFVVTGAVVA GVVIRRKRCS GSDSALGSDG LSLILKVRP // ID S9X419_CAMFR Unreviewed; 345 AA. AC S9X419; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 28-FEB-2018, entry version 25. DE SubName: Full=MHC class I heavy chain {ECO:0000313|EMBL:EPY85362.1}; GN ORFNames=CB1_000383010 {ECO:0000313|EMBL:EPY85362.1}; OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Tylopoda; OC Camelidae; Camelus. OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY85362.1, ECO:0000313|Proteomes:UP000030684}; RN [1] {ECO:0000313|EMBL:EPY85362.1, ECO:0000313|Proteomes:UP000030684} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684}; RX PubMed=23149746; RG Bactrian Camels Genome Sequencing and Analysis Consortium; RA Jirimutu null, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., RA Wang L., Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., RA Zhang W., Batmunkh M., Ts B., Narenbatu null, Unierhu null, RA Bat-Ireedui S., Gao H., Baysgalan B., Li Q., Jia Z., RA Turigenbayila null, Subudenggerile null, Narenmanduhu null, Wang Z., RA Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt null, Erdemt null, RA Altansha null, Altansukh null, Liu T., Cao M., Aruuntsever null, RA Bayart null, Hosblig null, He F., Zha-ti A., Zheng G., Qiu F., Sun Z., RA Zhao L., Zhao W., Liu B., Li C., Chen Y., Tang X., Guo C., Liu W., RA Ming L., Temuulen null, Cui A., Li Y., Gao J., Li J., Wurentaodi null, RA Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T., Bayaer T., RA Li Y., Meng H.; RT "Genome sequences of wild and domestic bactrian camels."; RL Nat. Commun. 3:1202-1202(2012). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB016672; EPY85362.1; -; Genomic_DNA. DR Proteomes; UP000030684; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000030684}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000030684}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 244 267 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 323 342 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 145 231 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 345 AA; 38151 MW; 4B82581562EC649C CRC64; MQPKARWAEQ EGPEYWEENT QNVKVSAQTF RLGLNILRGY YNQSEAVVGS GSHTYQWFCG CDAALDGRLL RGYNQFAYDG DDYIALNQDL LSWTAADTAA QITQRKWEAA GEAEKNRAYL DGACVEELLR FLENGKEMLQ RADPPKTHVT HHPISDHEVT LRCWALGFYP ADISLTWQRD GEDQAQDTEL VETRPAGDGT FQKWAAVVVP PGEEQRYTCH VQHEGLQEPL TLRWEPPPQP TVPIMGIIVG LVLFVVTGAV VAGVVIWRKR RSGEKGGSYA QAASSDSAQG SDVSLIDPRG GAGGGDEEPS VERACAQSVL SPLWALKWLL LGWVIFAVHV SLSLQ // ID S9X472_CAMFR Unreviewed; 256 AA. AC S9X472; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 18. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EPY85422.1}; GN ORFNames=CB1_000383009 {ECO:0000313|EMBL:EPY85422.1}; OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Tylopoda; OC Camelidae; Camelus. OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY85422.1, ECO:0000313|Proteomes:UP000030684}; RN [1] {ECO:0000313|EMBL:EPY85422.1, ECO:0000313|Proteomes:UP000030684} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684}; RX PubMed=23149746; RG Bactrian Camels Genome Sequencing and Analysis Consortium; RA Jirimutu null, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., RA Wang L., Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., RA Zhang W., Batmunkh M., Ts B., Narenbatu null, Unierhu null, RA Bat-Ireedui S., Gao H., Baysgalan B., Li Q., Jia Z., RA Turigenbayila null, Subudenggerile null, Narenmanduhu null, Wang Z., RA Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt null, Erdemt null, RA Altansha null, Altansukh null, Liu T., Cao M., Aruuntsever null, RA Bayart null, Hosblig null, He F., Zha-ti A., Zheng G., Qiu F., Sun Z., RA Zhao L., Zhao W., Liu B., Li C., Chen Y., Tang X., Guo C., Liu W., RA Ming L., Temuulen null, Cui A., Li Y., Gao J., Li J., Wurentaodi null, RA Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T., Bayaer T., RA Li Y., Meng H.; RT "Genome sequences of wild and domestic bactrian camels."; RL Nat. Commun. 3:1202-1202(2012). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB016672; EPY85422.1; -; Genomic_DNA. DR ProteinModelPortal; S9X472; -. DR Proteomes; UP000030684; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000030684}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000030684}. FT DOMAIN 132 221 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 256 AA; 27973 MW; BDA44926A46C1A4A CRC64; MEPEPEGHCS VGAGLHSLQE TVGCEIREDG QARGFRSICY DGKLFLSCHP ETHGCRVPQS LDQTLAMEIK KSWDTDGFQS KHYWAHVQGE LCARLRSYVE SRMGFTDRTG CKADLEKGWG GRGLSQSWRV PPAVNVTLSQ ALEGRVNLSC WAFDFFPWNI SVAWLQDEDP VSQDAQQSGG VLPDGNGTYW TWVTVNIPQG EEQRFTCHVD HSGNHSAHPV SSGEAGVIPE GVLTLGGSET RVGEREQACG SGVPGL // ID S9XE05_CAMFR Unreviewed; 532 AA. AC S9XE05; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 12-SEP-2018, entry version 28. DE SubName: Full=Histocompatibility 2, Q region locus 10-like protein {ECO:0000313|EMBL:EPY85924.1}; GN ORFNames=CB1_000339035 {ECO:0000313|EMBL:EPY85924.1}; OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Tylopoda; OC Camelidae; Camelus. OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY85924.1, ECO:0000313|Proteomes:UP000030684}; RN [1] {ECO:0000313|EMBL:EPY85924.1, ECO:0000313|Proteomes:UP000030684} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684}; RX PubMed=23149746; RG Bactrian Camels Genome Sequencing and Analysis Consortium; RA Jirimutu null, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., RA Wang L., Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., RA Zhang W., Batmunkh M., Ts B., Narenbatu null, Unierhu null, RA Bat-Ireedui S., Gao H., Baysgalan B., Li Q., Jia Z., RA Turigenbayila null, Subudenggerile null, Narenmanduhu null, Wang Z., RA Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt null, Erdemt null, RA Altansha null, Altansukh null, Liu T., Cao M., Aruuntsever null, RA Bayart null, Hosblig null, He F., Zha-ti A., Zheng G., Qiu F., Sun Z., RA Zhao L., Zhao W., Liu B., Li C., Chen Y., Tang X., Guo C., Liu W., RA Ming L., Temuulen null, Cui A., Li Y., Gao J., Li J., Wurentaodi null, RA Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T., Bayaer T., RA Li Y., Meng H.; RT "Genome sequences of wild and domestic bactrian camels."; RL Nat. Commun. 3:1202-1202(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB016629; EPY85924.1; -; Genomic_DNA. DR ProteinModelPortal; S9XE05; -. DR Proteomes; UP000030684; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005622; C:intracellular; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR CDD; cd00021; BBOX; 1. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR000315; Znf_B-box. DR InterPro; IPR001841; Znf_RING. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR InterPro; IPR017907; Znf_RING_CS. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00336; BBOX; 1. DR SMART; SM00407; IGc1; 1. DR SMART; SM00184; RING; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. DR PROSITE; PS50119; ZF_BBOX; 1. DR PROSITE; PS00518; ZF_RING_1; 1. DR PROSITE; PS50089; ZF_RING_2; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000030684}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175, KW ECO:0000256|SAAS:SAAS00139444}; KW Reference proteome {ECO:0000313|Proteomes:UP000030684}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175, KW ECO:0000256|SAAS:SAAS00139444}; KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175, KW ECO:0000256|SAAS:SAAS00139444}. FT TRANSMEM 296 321 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 198 284 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 349 375 RING-type. {ECO:0000259|PROSITE:PS50089}. FT DOMAIN 457 498 B box-type. FT {ECO:0000259|PROSITE:PS50119}. SQ SEQUENCE 532 AA; 60760 MW; A3B0AA5EC6B78E23 CRC64; MAELAHLELE NKPWPKGTHS LIYHYLALSE PGPGLPQFLA VGYVDDQPFI QYDSRVGQAE PQAPWAASMD AQYWETETKK QRIWAEVQQV EMWTVMGYHN QSSGMHSTQR MFGCEIQEDG RFSSFWQFGY DGQDHLSLDL ESLSWVSAVP VAVRTKRWWE TERCYAEYDK AYLEGVCLPY LLRYLELGGQ RFSRREPPTV RVTQHSAQDG GTTLRCWALG FYPQDISLTW WLDEKQLISK TEYVDIRPSG DGTYQTWVAV QVPAGEESRY TCHVQHSSLN HTLTGSWEWP SHHTHFAIII SLILVVLVAG VILTKCLHAL IHTGRQLVKM TGYASTPNPT QTLQQEAVCA ICLDYLKDPV SIGCGHNLCR GCVTQLWGKE DDEEDRDVEE DEWENEEDHE AVGAVGVWDD PIREVLYRGN ADKLLFEDQE DDELWLANVV QIIRQMCPTP NKGSQGNDQG ICSKHQEAFK HFCEVDKEAI RVVCRESRSH RQHSVVPLEE VVQEYKVSSM REYGDLKGVE KKQGELGEMG TG // ID S9XJ80_CAMFR Unreviewed; 280 AA. AC S9XJ80; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 28-FEB-2018, entry version 17. DE SubName: Full=Major histocompatibility complex class I-related gene protein isoform 3 {ECO:0000313|EMBL:EPY75256.1}; DE Flags: Fragment; GN ORFNames=CB1_001726001 {ECO:0000313|EMBL:EPY75256.1}; OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Tylopoda; OC Camelidae; Camelus. OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY75256.1, ECO:0000313|Proteomes:UP000030684}; RN [1] {ECO:0000313|EMBL:EPY75256.1, ECO:0000313|Proteomes:UP000030684} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684}; RX PubMed=23149746; RG Bactrian Camels Genome Sequencing and Analysis Consortium; RA Jirimutu null, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., RA Wang L., Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., RA Zhang W., Batmunkh M., Ts B., Narenbatu null, Unierhu null, RA Bat-Ireedui S., Gao H., Baysgalan B., Li Q., Jia Z., RA Turigenbayila null, Subudenggerile null, Narenmanduhu null, Wang Z., RA Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt null, Erdemt null, RA Altansha null, Altansukh null, Liu T., Cao M., Aruuntsever null, RA Bayart null, Hosblig null, He F., Zha-ti A., Zheng G., Qiu F., Sun Z., RA Zhao L., Zhao W., Liu B., Li C., Chen Y., Tang X., Guo C., Liu W., RA Ming L., Temuulen null, Cui A., Li Y., Gao J., Li J., Wurentaodi null, RA Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T., Bayaer T., RA Li Y., Meng H.; RT "Genome sequences of wild and domestic bactrian camels."; RL Nat. Commun. 3:1202-1202(2012). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB017854; EPY75256.1; -; Genomic_DNA. DR ProteinModelPortal; S9XJ80; -. DR Proteomes; UP000030684; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 2. DR SUPFAM; SSF54452; SSF54452; 2. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000030684}; KW Reference proteome {ECO:0000313|Proteomes:UP000030684}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 280 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004560768. FT DOMAIN 20 107 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 171 259 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT COILED 223 243 {ECO:0000256|SAM:Coils}. FT NON_TER 280 280 {ECO:0000313|EMBL:EPY75256.1}. SQ SEQUENCE 280 AA; 31814 MW; 803A8B63DE80953F CRC64; MVLLLPLIVV LTAKHSDARS HSLRYFRLGV SDPGHGIPEF ISVGYVDSHP ITTYDSVSRR KEPRALWVAE NLAPDHWERH TQLLRGWQQT FTVELKQLRH HYNHSGDEGS RGGLLSSPAP VPVERSLGWQ QMSPLPPYPC PVPVQAADLY APLSHPECGC GVCHFLVARL GLHTYQRMMG CELLEDGSTT GFLQYAYDGQ DFLIFNKDTL SWMAMDNVAH ITKRAWEANR HELQYQKNWL EEECIACLKR FLEYGKDTLQ RTGVPCDDEN ELGNAIVKFS // ID S9XN76_CAMFR Unreviewed; 516 AA. AC S9XN76; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 22-NOV-2017, entry version 25. DE SubName: Full=Reticulocalbin-3 {ECO:0000313|EMBL:EPY89114.1}; GN ORFNames=CB1_000132026 {ECO:0000313|EMBL:EPY89114.1}; OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Tylopoda; OC Camelidae; Camelus. OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY89114.1, ECO:0000313|Proteomes:UP000030684}; RN [1] {ECO:0000313|EMBL:EPY89114.1, ECO:0000313|Proteomes:UP000030684} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684}; RX PubMed=23149746; RG Bactrian Camels Genome Sequencing and Analysis Consortium; RA Jirimutu null, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., RA Wang L., Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., RA Zhang W., Batmunkh M., Ts B., Narenbatu null, Unierhu null, RA Bat-Ireedui S., Gao H., Baysgalan B., Li Q., Jia Z., RA Turigenbayila null, Subudenggerile null, Narenmanduhu null, Wang Z., RA Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt null, Erdemt null, RA Altansha null, Altansukh null, Liu T., Cao M., Aruuntsever null, RA Bayart null, Hosblig null, He F., Zha-ti A., Zheng G., Qiu F., Sun Z., RA Zhao L., Zhao W., Liu B., Li C., Chen Y., Tang X., Guo C., Liu W., RA Ming L., Temuulen null, Cui A., Li Y., Gao J., Li J., Wurentaodi null, RA Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T., Bayaer T., RA Li Y., Meng H.; RT "Genome sequences of wild and domestic bactrian camels."; RL Nat. Commun. 3:1202-1202(2012). CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB016430; EPY89114.1; -; Genomic_DNA. DR ProteinModelPortal; S9XN76; -. DR Proteomes; UP000030684; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR018247; EF_Hand_1_Ca_BS. DR InterPro; IPR002048; EF_hand_dom. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF13202; EF-hand_5; 2. DR Pfam; PF13833; EF-hand_8; 1. DR Pfam; PF00129; MHC_I; 2. DR SMART; SM00054; EFh; 3. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF47473; SSF47473; 2. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS00018; EF_HAND_1; 4. DR PROSITE; PS50222; EF_HAND_2; 6. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Calcium {ECO:0000256|PROSITE-ProRule:PRU00448}; KW Complete proteome {ECO:0000313|Proteomes:UP000030684}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000030684}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 516 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004573281. FT DOMAIN 168 255 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 263 300 EF-hand. {ECO:0000259|PROSITE:PS50222}. FT DOMAIN 301 336 EF-hand. {ECO:0000259|PROSITE:PS50222}. FT DOMAIN 351 386 EF-hand. {ECO:0000259|PROSITE:PS50222}. FT DOMAIN 388 423 EF-hand. {ECO:0000259|PROSITE:PS50222}. FT DOMAIN 442 464 EF-hand. {ECO:0000259|PROSITE:PS50222}. FT DOMAIN 465 500 EF-hand. {ECO:0000259|PROSITE:PS50222}. FT CA_BIND 314 325 {ECO:0000256|PROSITE-ProRule:PRU00448}. FT CA_BIND 401 412 {ECO:0000256|PROSITE-ProRule:PRU00448}. FT CA_BIND 442 453 {ECO:0000256|PROSITE-ProRule:PRU00448}. FT CA_BIND 478 489 {ECO:0000256|PROSITE-ProRule:PRU00448}. SQ SEQUENCE 516 AA; 58681 MW; E1BC010C50FACC5C CRC64; MRVPRSQPWG LALLLLLLPG TLRAAESHRS LLYHFTAVSN PASGTPAFWV SGWLGPQQYL SYNNLRAQAE PYGAWVWESQ GLLGCELGPD NVSVPMAKYA LNGEEFMEFD PKLGIWDGDW PEARTVGIKW MKHPEAVNKE KTFLLYSCPH RLLGHLERGR GNLEWKEPPS MRLKARPGNP GFSVLTCSAF SFYPPELQLR FLRNGLAAGS GEGDVVPNGD GSFYAWSSLT VKSGDEHQYR CWVQHVGLAQ PLTVELGEVP LGEDTPYFWR IVDRMDRAGD GDGWVSLTEL RAWIAHTQQR HIRDSVSAAW NTYDTDRDGR VGWEELRNAT YGHYEPGEEF HDVEDAETYK KMLARDERRF RVADQDGDSV ATREELTAFL HPEEFPHMRD IVIAETLEDL DKNKDGYVQV EEYIADLYSA EPGEEEPAWV QTEREQFRDF RDLNKDGRLD GSEVGHWVLP PAQDQPLVEA NHLLHESDTD KDGRLSKAEI LGNWNMFVGS QATNYGEDLT RHHDEL // ID S9YFV4_CAMFR Unreviewed; 388 AA. AC S9YFV4; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 26. DE SubName: Full=Hereditary hemochromatosis protein {ECO:0000313|EMBL:EPY83110.1}; GN ORFNames=CB1_000595037 {ECO:0000313|EMBL:EPY83110.1}; OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Tylopoda; OC Camelidae; Camelus. OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY83110.1, ECO:0000313|Proteomes:UP000030684}; RN [1] {ECO:0000313|EMBL:EPY83110.1, ECO:0000313|Proteomes:UP000030684} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684}; RX PubMed=23149746; RG Bactrian Camels Genome Sequencing and Analysis Consortium; RA Jirimutu null, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., RA Wang L., Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., RA Zhang W., Batmunkh M., Ts B., Narenbatu null, Unierhu null, RA Bat-Ireedui S., Gao H., Baysgalan B., Li Q., Jia Z., RA Turigenbayila null, Subudenggerile null, Narenmanduhu null, Wang Z., RA Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt null, Erdemt null, RA Altansha null, Altansukh null, Liu T., Cao M., Aruuntsever null, RA Bayart null, Hosblig null, He F., Zha-ti A., Zheng G., Qiu F., Sun Z., RA Zhao L., Zhao W., Liu B., Li C., Chen Y., Tang X., Guo C., Liu W., RA Ming L., Temuulen null, Cui A., Li Y., Gao J., Li J., Wurentaodi null, RA Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T., Bayaer T., RA Li Y., Meng H.; RT "Genome sequences of wild and domestic bactrian camels."; RL Nat. Commun. 3:1202-1202(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB016868; EPY83110.1; -; Genomic_DNA. DR ProteinModelPortal; S9YFV4; -. DR Proteomes; UP000030684; Unassembled WGS sequence. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:1990459; F:transferrin receptor binding; IEA:InterPro. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:InterPro. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000030684}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000030684}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 388 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004573571. FT TRANSMEM 357 380 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 215 304 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 388 AA; 43907 MW; A0B4A2C2628B0E2A CRC64; MGPRARPALL LLILLRTVDT QGRPRRSHSL RYLFMGASEP DLGLPLFEAL GFVDDQLFVS YDHESRRVEP RTPWVWGQAT SQLWLQLSQS LKGWDHMFIV DFWTIMDNHN HSKVPKLGLW PESHTLQVIL GCEVHADNST RGFWKYGYDG QDHLEFCPET LDWRAAEPQA WATKLEWEVN KIRSKQNRAY LERDCPEQLR RLLELGRGVL GQQAPPLVKV SHHVTSAVTT LRCQALNFYP QHITMRWLKD RQPLDAKDAE PENVLPNGDG TYQGWVALAV LPGEEQRYTC QVEHPGLEQP LTASWGMDEN QRRGKPGMGG MGVVNIAVRG GSALSWDSSH QLSLTFDLLE PSLSGTLVIG IISGIAVCVI IFTGISFRVL KRRQSSSE // ID T0M664_CAMFR Unreviewed; 193 AA. AC T0M664; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 18. DE SubName: Full=Zinc-alpha-2-glycoprotein-like protein {ECO:0000313|EMBL:EQB77914.1}; GN ORFNames=CB1_000537017 {ECO:0000313|EMBL:EQB77914.1}; OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Tylopoda; OC Camelidae; Camelus. OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EQB77914.1, ECO:0000313|Proteomes:UP000030684}; RN [1] {ECO:0000313|EMBL:EQB77914.1, ECO:0000313|Proteomes:UP000030684} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684}; RX PubMed=23149746; RG Bactrian Camels Genome Sequencing and Analysis Consortium; RA Jirimutu null, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., RA Wang L., Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., RA Zhang W., Batmunkh M., Ts B., Narenbatu null, Unierhu null, RA Bat-Ireedui S., Gao H., Baysgalan B., Li Q., Jia Z., RA Turigenbayila null, Subudenggerile null, Narenmanduhu null, Wang Z., RA Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt null, Erdemt null, RA Altansha null, Altansukh null, Liu T., Cao M., Aruuntsever null, RA Bayart null, Hosblig null, He F., Zha-ti A., Zheng G., Qiu F., Sun Z., RA Zhao L., Zhao W., Liu B., Li C., Chen Y., Tang X., Guo C., Liu W., RA Ming L., Temuulen null, Cui A., Li Y., Gao J., Li J., Wurentaodi null, RA Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T., Bayaer T., RA Li Y., Meng H.; RT "Genome sequences of wild and domestic bactrian camels."; RL Nat. Commun. 3:1202-1202(2012). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB016817; EQB77914.1; -; Genomic_DNA. DR ProteinModelPortal; T0M664; -. DR Proteomes; UP000030684; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000030684}; KW Reference proteome {ECO:0000313|Proteomes:UP000030684}. FT DOMAIN 88 173 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 193 AA; 21903 MW; 06FB06A67FF477A6 CRC64; MFGCELRRNK SSGAFWRYAY DGQDFIEFNK EIPAWVALDP AALNTKQKWE AEEVYVQRAK AYLEEECPGM LRRYLKYSRT HLDRQESPSM SVTSHVAPGK TRTLKCLAYD FYPRGIRLHW TQPGNVQETE SGGDVLPNGN GSYQSWVVVG VLAQDRAPHS CHVEHSSLAR PLTVPWDARQ EARAEGDVGA QTQ // ID T0MHD1_CAMFR Unreviewed; 173 AA. AC T0MHD1; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EQB77915.1}; GN ORFNames=CB1_000537018 {ECO:0000313|EMBL:EQB77915.1}; OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Tylopoda; OC Camelidae; Camelus. OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EQB77915.1, ECO:0000313|Proteomes:UP000030684}; RN [1] {ECO:0000313|EMBL:EQB77915.1, ECO:0000313|Proteomes:UP000030684} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684}; RX PubMed=23149746; RG Bactrian Camels Genome Sequencing and Analysis Consortium; RA Jirimutu null, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., RA Wang L., Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., RA Zhang W., Batmunkh M., Ts B., Narenbatu null, Unierhu null, RA Bat-Ireedui S., Gao H., Baysgalan B., Li Q., Jia Z., RA Turigenbayila null, Subudenggerile null, Narenmanduhu null, Wang Z., RA Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt null, Erdemt null, RA Altansha null, Altansukh null, Liu T., Cao M., Aruuntsever null, RA Bayart null, Hosblig null, He F., Zha-ti A., Zheng G., Qiu F., Sun Z., RA Zhao L., Zhao W., Liu B., Li C., Chen Y., Tang X., Guo C., Liu W., RA Ming L., Temuulen null, Cui A., Li Y., Gao J., Li J., Wurentaodi null, RA Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T., Bayaer T., RA Li Y., Meng H.; RT "Genome sequences of wild and domestic bactrian camels."; RL Nat. Commun. 3:1202-1202(2012). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KB016817; EQB77915.1; -; Genomic_DNA. DR ProteinModelPortal; T0MHD1; -. DR Proteomes; UP000030684; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000030684}; KW Reference proteome {ECO:0000313|Proteomes:UP000030684}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 173 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004567747. FT DOMAIN 24 109 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 173 AA; 19811 MW; 7EC6B24AA39FA848 CRC64; MAPVLLSLLL LLGPAVPEET QAGPYSLRFL YTGLSRPSKG FPSFQATAYL NDQPFFHYDS EGRKAEPLGP WSQVEGMEDW EKESELQKAR EDIFMVTLKD IMDHYKDGEG LVSEDKNAQE AMWYLKVSPK RQEFCRNEKD VGGWENGLGC VQSKKEYRTD ARKDAGRHSN WLE // ID U3I7A4_ANAPL Unreviewed; 110 AA. AC U3I7A4; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 20-JUN-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAPLP00000003125}; GN Name=LOC101794830 {ECO:0000313|Ensembl:ENSAPLP00000003125}; OS Anas platyrhynchos (Mallard) (Anas boschas). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; OC Anatinae; Anas. OX NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000003125, ECO:0000313|Proteomes:UP000016666}; RN [1] {ECO:0000313|Ensembl:ENSAPLP00000003125} RP NUCLEOTIDE SEQUENCE. RA Li N.; RT "The genome sequence and transcriptome of duck provide insight into RT the interaction host."; RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAPLP00000003125} RP NUCLEOTIDE SEQUENCE. RX PubMed=23749191; DOI=10.1038/ng.2657; RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., RA Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., RA Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., RA Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J., RA Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G., RA Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M., RA Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J., RA Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J., RA Li N.; RT "The duck genome and transcriptome provide insight into an avian RT influenza virus reservoir species."; RL Nat. Genet. 45:776-783(2013). RN [3] {ECO:0000313|Ensembl:ENSAPLP00000003125} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADON01131126; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; U3I7A4; -. DR Ensembl; ENSAPLT00000003720; ENSAPLP00000003125; ENSAPLG00000003647. DR GeneTree; ENSGT00900000141162; -. DR OMA; CRSHSAM; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000016666; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000016666}; KW Reference proteome {ECO:0000313|Proteomes:UP000016666}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 110 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004643285. FT DOMAIN 23 109 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 110 AA; 12383 MW; 42EA979FBA791202 CRC64; RAGALGLVLG LLLGVLGGAA SEPHSLRYFY TAVSDPSPGV PQFMIVGSVD GEVFVRYDSE TRRVESRVDW TSAIDDQEYW EKNTRIAQNT EQTYRVNLDI LRERYNQSRG // ID U3IA71_ANAPL Unreviewed; 180 AA. AC U3IA71; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 20-JUN-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAPLP00000004142}; GN Name=LOC101790497 {ECO:0000313|Ensembl:ENSAPLP00000004142}; OS Anas platyrhynchos (Mallard) (Anas boschas). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; OC Anatinae; Anas. OX NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000004142, ECO:0000313|Proteomes:UP000016666}; RN [1] {ECO:0000313|Ensembl:ENSAPLP00000004142} RP NUCLEOTIDE SEQUENCE. RA Li N.; RT "The genome sequence and transcriptome of duck provide insight into RT the interaction host."; RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAPLP00000004142} RP NUCLEOTIDE SEQUENCE. RX PubMed=23749191; DOI=10.1038/ng.2657; RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., RA Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., RA Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., RA Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J., RA Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G., RA Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M., RA Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J., RA Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J., RA Li N.; RT "The duck genome and transcriptome provide insight into an avian RT influenza virus reservoir species."; RL Nat. Genet. 45:776-783(2013). RN [3] {ECO:0000313|Ensembl:ENSAPLP00000004142} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADON01155941; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; U3IA71; -. DR Ensembl; ENSAPLT00000004751; ENSAPLP00000004142; ENSAPLG00000004628. DR GeneTree; ENSGT00900000141162; -. DR OMA; WKGILER; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000016666; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000016666}; KW Reference proteome {ECO:0000313|Proteomes:UP000016666}. FT DOMAIN 24 180 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 180 AA; 20478 MW; C4EC817D9FA40DD5 CRC64; CRPPRGLSLH SGLPLSAAPV PAEPHSLRYF LTAVSDPIPG VPQLVTVGSV DGEVFVYYDS ETRRKEPRAD WIAAHTNQHY WDSQTEISRM NEQIFRVGLE TLRERYNQSR GSHTLQHVYG CDLLEDGSIR GFDQYGYDGR EFIAFDKNTE TYTAADAGAQ ITKRKWEEDG TVAEQMKYYL // ID U3IC55_ANAPL Unreviewed; 220 AA. AC U3IC55; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 20-JUN-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAPLP00000004827}; OS Anas platyrhynchos (Mallard) (Anas boschas). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; OC Anatinae; Anas. OX NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000004827, ECO:0000313|Proteomes:UP000016666}; RN [1] {ECO:0000313|Ensembl:ENSAPLP00000004827} RP NUCLEOTIDE SEQUENCE. RA Li N.; RT "The genome sequence and transcriptome of duck provide insight into RT the interaction host."; RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAPLP00000004827} RP NUCLEOTIDE SEQUENCE. RX PubMed=23749191; DOI=10.1038/ng.2657; RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., RA Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., RA Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., RA Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J., RA Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G., RA Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M., RA Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J., RA Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J., RA Li N.; RT "The duck genome and transcriptome provide insight into an avian RT influenza virus reservoir species."; RL Nat. Genet. 45:776-783(2013). RN [3] {ECO:0000313|Ensembl:ENSAPLP00000004827} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADON01127565; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADON01127566; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADON01127567; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADON01127568; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAPLT00000005448; ENSAPLP00000004827; ENSAPLG00000005279. DR GeneTree; ENSGT00390000001159; -. DR OrthoDB; EOG091G0JCK; -. DR Proteomes; UP000016666; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR015669; Endothetial_C_recpt. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR PANTHER; PTHR15349; PTHR15349; 1. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000016666}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000016666}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 220 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004643256. FT TRANSMEM 194 215 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 97 178 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 220 AA; 23897 MW; AF926F6076613E8C CRC64; LLLLCGALGC GAQGTAPLAF TMLQWTRVSK GSSDFWGNAT LGGRLSHLLE GHNVTQVLPL EPPAAWEQRQ EVVGNYLTYF SELVWXXXXX XXXXXTQSLC CRLGCCLFPN GTARSFYEIT LNGTAFLTFH VPTATWECRW PGKDPVASFA QRELMKYPET TRDLQYFLNT TCVDILRAQS PETGKQSSRS HAPLALGLSV GVLAVLGMAG GIFLCTGGSC // ID U3IS38_ANAPL Unreviewed; 121 AA. AC U3IS38; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 28-MAR-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAPLP00000010061}; OS Anas platyrhynchos (Mallard) (Anas boschas). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; OC Anatinae; Anas. OX NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000010061, ECO:0000313|Proteomes:UP000016666}; RN [1] {ECO:0000313|Ensembl:ENSAPLP00000010061} RP NUCLEOTIDE SEQUENCE. RA Li N.; RT "The genome sequence and transcriptome of duck provide insight into RT the interaction host."; RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAPLP00000010061} RP NUCLEOTIDE SEQUENCE. RX PubMed=23749191; DOI=10.1038/ng.2657; RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., RA Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., RA Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., RA Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J., RA Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G., RA Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M., RA Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J., RA Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J., RA Li N.; RT "The duck genome and transcriptome provide insight into an avian RT influenza virus reservoir species."; RL Nat. Genet. 45:776-783(2013). RN [3] {ECO:0000313|Ensembl:ENSAPLP00000010061} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADON01150975; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADON01150976; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; U3IS38; -. DR Ensembl; ENSAPLT00000010767; ENSAPLP00000010061; ENSAPLG00000010345. DR GeneTree; ENSGT00900000141162; -. DR OMA; LEYWDRE; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000016666; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000016666}; KW Reference proteome {ECO:0000313|Proteomes:UP000016666}. FT DOMAIN 28 115 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 121 AA; 13282 MW; E2B6084A1E2C8808 CRC64; QAGALGLGLE LGLPLGLPLS AAPVPAEPHS LRYFYTAVSD ASPGVPQFMS VGYVDGHLID RYDSETRRDE PGAGWIAANM DQQYWDRQTE TLQGIEQVFR MGLDALQECY NQSRGENGWG H // ID U3ITP1_ANAPL Unreviewed; 112 AA. AC U3ITP1; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 28-MAR-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAPLP00000010614}; OS Anas platyrhynchos (Mallard) (Anas boschas). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; OC Anatinae; Anas. OX NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000010614, ECO:0000313|Proteomes:UP000016666}; RN [1] {ECO:0000313|Ensembl:ENSAPLP00000010614} RP NUCLEOTIDE SEQUENCE. RA Li N.; RT "The genome sequence and transcriptome of duck provide insight into RT the interaction host."; RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAPLP00000010614} RP NUCLEOTIDE SEQUENCE. RX PubMed=23749191; DOI=10.1038/ng.2657; RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., RA Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., RA Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., RA Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J., RA Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G., RA Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M., RA Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J., RA Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J., RA Li N.; RT "The duck genome and transcriptome provide insight into an avian RT influenza virus reservoir species."; RL Nat. Genet. 45:776-783(2013). RN [3] {ECO:0000313|Ensembl:ENSAPLP00000010614} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADON01145625; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAPLT00000011331; ENSAPLP00000010614; ENSAPLG00000010891. DR GeneTree; ENSGT00900000141162; -. DR OMA; WDSETEI; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000016666; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000016666}; KW Reference proteome {ECO:0000313|Proteomes:UP000016666}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 112 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004644722. FT DOMAIN 25 111 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 112 AA; 12584 MW; 2B5F3FF0B421F083 CRC64; VGVPFPGLGL LLLLLGVLVG AASEPHSLRY FYTAVSDPGP GVPHFVTVGY VDGHLIDHYD SETQRTEPRV DWIAANTDQQ YWDSETEISQ RSEQVFRGHL ETLRERYNQS RG // ID U3IUP1_ANAPL Unreviewed; 114 AA. AC U3IUP1; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 28-MAR-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAPLP00000010964}; OS Anas platyrhynchos (Mallard) (Anas boschas). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; OC Anatinae; Anas. OX NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000010964, ECO:0000313|Proteomes:UP000016666}; RN [1] {ECO:0000313|Ensembl:ENSAPLP00000010964} RP NUCLEOTIDE SEQUENCE. RA Li N.; RT "The genome sequence and transcriptome of duck provide insight into RT the interaction host."; RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAPLP00000010964} RP NUCLEOTIDE SEQUENCE. RX PubMed=23749191; DOI=10.1038/ng.2657; RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., RA Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., RA Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., RA Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J., RA Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G., RA Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M., RA Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J., RA Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J., RA Li N.; RT "The duck genome and transcriptome provide insight into an avian RT influenza virus reservoir species."; RL Nat. Genet. 45:776-783(2013). RN [3] {ECO:0000313|Ensembl:ENSAPLP00000010964} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADON01161253; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; U3IUP1; -. DR Ensembl; ENSAPLT00000011683; ENSAPLP00000010964; ENSAPLG00000011234. DR GeneTree; ENSGT00900000141162; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000016666; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000016666}; KW Reference proteome {ECO:0000313|Proteomes:UP000016666}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 114 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004644758. FT DOMAIN 27 112 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 114 AA; 13155 MW; 707C9A9518C804B6 CRC64; LLWSGGIRLL LLLLLGVLGG AEREPLYLRY FYTAVSDPSP GVPQSVAVAW LGRSLCYNSK TRRKEPRVDW IVANKDQQYW GRETETSKSN EKFFRVNLDT LRECYNQSRG ESRL // ID U3J601_ANAPL Unreviewed; 347 AA. AC U3J601; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 12-SEP-2018, entry version 31. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSAPLP00000014928}; GN Name=MR1 {ECO:0000313|Ensembl:ENSAPLP00000014928}; OS Anas platyrhynchos (Mallard) (Anas boschas). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; OC Anatinae; Anas. OX NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000014928, ECO:0000313|Proteomes:UP000016666}; RN [1] {ECO:0000313|Ensembl:ENSAPLP00000014928} RP NUCLEOTIDE SEQUENCE. RA Li N.; RT "The genome sequence and transcriptome of duck provide insight into RT the interaction host."; RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAPLP00000014928} RP NUCLEOTIDE SEQUENCE. RX PubMed=23749191; DOI=10.1038/ng.2657; RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., RA Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., RA Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., RA Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J., RA Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G., RA Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M., RA Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J., RA Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J., RA Li N.; RT "The duck genome and transcriptome provide insight into an avian RT influenza virus reservoir species."; RL Nat. Genet. 45:776-783(2013). RN [3] {ECO:0000313|Ensembl:ENSAPLP00000014928} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ADON01141745; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADON01141746; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAPLT00000015715; ENSAPLP00000014928; ENSAPLG00000015082. DR GeneTree; ENSGT00740000114936; -. DR OMA; KTHITHY; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000016666; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000016666}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000016666}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 294 318 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 347 AA; 38605 MW; A84FA55529026ECA CRC64; APPGLGLPSG LPLSAARVPA EPHSLRYFYT AVSEPSPGVP QYVAVGYVDG EAFTYYDSET RRTEPRVDWI AAHMDQQYWD RETENFQRSE QFYRVGLDTL RERYNQSRGS HTVQRMYGCD LLEDGSITGF DQYGYDGRDF IAFDKDTLTL TAADAGAQIT KRKTETEGTY AEQTKYYLEN TCIEWLRKYV SYGKDVLERR GEAEGGCSTN KILTLSCRAH GFYPRPISIS WLKDGVVQEQ ETQRGSTVPN SDGTYHVWAT IDVLPGDRDK YQCRVEHASL PQPGLFSWEP QSNLIPIVAG VAVAVVAVIA ALAGFAVWKS KQGNVPGRYN VASVNDGESN SSNTGTE // ID U3JB89_FICAL Unreviewed; 336 AA. AC U3JB89; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 23-MAY-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFALP00000000043}; OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; OC Ficedula. OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000000043, ECO:0000313|Proteomes:UP000016665}; RN [1] {ECO:0000313|Ensembl:ENSFALP00000000043} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTO01022761; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; U3JB89; -. DR Ensembl; ENSFALT00000000043; ENSFALP00000000043; ENSFALG00000000038. DR GeneTree; ENSGT00740000114936; -. DR OMA; QPRFIAV; -. DR OrthoDB; EOG091G0TWV; -. DR Proteomes; UP000016665; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000016665}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000016665}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 279 301 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 181 270 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 336 AA; 38636 MW; A00547F758049368 CRC64; LHSLHYLNMA VSEPSPEVPE FMTIGYLDGI PFVRYDSKRG RLEWIEDRGE PGYWDWMTQT CERNQHMDAW NLEMLQDQYN QTLGLHTSWV YGCDLLSDGN ISGSSRFGYD GQDFISFDPG SRRFVAANSI AEVTRRRWEG ETNEVEMRAN YLEHVCPEWL QKYIGYGQKE LDHKVIPFQS PLMSIHVSGK EEHGTLILSC HAYRFYPSTI AVNWMKGDEF PDQEMEWGRV VPNSNGTFHT WARIEARLEE REQYWCRVEH PGMSEPGIFT WELTSGGNLT VVVAVSIAAI IILIVVIRFV VWRCQSSNTR DGGQEGAQIH PAPFWISCAT NTDPTV // ID U3JEY0_FICAL Unreviewed; 386 AA. AC U3JEY0; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 20-JUN-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFALP00000001334}; OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; OC Ficedula. OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000001334, ECO:0000313|Proteomes:UP000016665}; RN [1] {ECO:0000313|Ensembl:ENSFALP00000001334} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTO01012209; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSFALT00000001341; ENSFALP00000001334; ENSFALG00000001276. DR GeneTree; ENSGT00740000114936; -. DR OMA; FQRMIGC; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000016665; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000016665}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000016665}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 38 {ECO:0000256|SAM:SignalP}. FT CHAIN 39 386 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004644465. FT TRANSMEM 324 348 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 228 305 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 386 AA; 42984 MW; 02380E846C9E8A3E CRC64; MAVPEAALGA GPALGAGPRR SGAVALVLAL GLLSGLLGDR GGATRVLHSL SCLSVAVSEP SPGVPQFLST GYLDGIPFVR YDSERGRAEP LTQWIKDGAE PGYWDRKTQT CERHQHVAAR NLDILRDRYN QSGGEWTWLR LYSCDLLSDG SVRGSYRNGY DGRDFISFDL GSERFVAADS AAEVTRRRWE HETNEVERWT NYLEHDCLDR LQKYIGYGQK ELDRKEPPAV HVSGKEEHGM LILSCHAYGF YPNAIAVNWM KGDEIRDQET EWGGVVPNSD GTFHTWARIE ARPEEREQYR CKVEHPGMPE PGIFAWEPTS GRNLTVLVAV SIIAAIIILT VLIGFVVWKR QSGRRDRNEN SMAARSGRDS REVLGQDGSS RIGVGW // ID U3JLF3_FICAL Unreviewed; 358 AA. AC U3JLF3; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 23-MAY-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFALP00000003607}; GN Name=LOC101821968 {ECO:0000313|Ensembl:ENSFALP00000003607}; OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; OC Ficedula. OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000003607, ECO:0000313|Proteomes:UP000016665}; RN [1] {ECO:0000313|Ensembl:ENSFALP00000003607} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTO01023093; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_016161180.1; XM_016305694.1. DR Ensembl; ENSFALT00000003621; ENSFALP00000003607; ENSFALG00000003452. DR GeneID; 101821968; -. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000016665; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000016665}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000016665}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 358 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004644663. FT TRANSMEM 303 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 284 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 358 AA; 40502 MW; D546CC5481C21927 CRC64; MAPALGLGLL LALLALLGDP GGATKVLHSL RYLHVAVSEP SLGIPQFMSV GYLDGIPFTR YDSERGRMEP LTQWIKDSAD PEYWDRVTQI CVGSQHVTAW NLQTVRDRYN QTRDPQTRLQ VYGCDLLSDG SIHGSYRVGY DWWDYISFDL ESKRFLAADN AAEATRRRWE DENEAERWTN YLGHICPEWL QKYVRYGQKE LDRKEPPDVH VSGKEEHGML ILSCHAYGFY PNAIAVNWMK GDEIRDQETE WGGVVPNSDG TFHTWARIEA RPEEREQYRC KVEHPGMPEP GIFAWEPTSG GNLTVVIAVS IVAAIIILAV LIGFVVWRLQ SGRWDRNKYS MAPEKDGGTN GLSAAITA // ID U3JLF4_FICAL Unreviewed; 386 AA. AC U3JLF4; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 23-MAY-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFALP00000003608}; GN Name=LOC101821968 {ECO:0000313|Ensembl:ENSFALP00000003608}; OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; OC Ficedula. OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000003608, ECO:0000313|Proteomes:UP000016665}; RN [1] {ECO:0000313|Ensembl:ENSFALP00000003608} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTO01023093; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSFALT00000003622; ENSFALP00000003608; ENSFALG00000003452. DR GeneTree; ENSGT00740000114936; -. DR OMA; VPGYYNQ; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000016665; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000016665}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000016665}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 386 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004645518. FT TRANSMEM 303 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 284 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 386 AA; 43693 MW; F85D2DAB3E9699CA CRC64; MAPALGLGLL LALLALLGDP GGATKVLHSL RYLHVAVSEP SLGIPQFMSV GYLDGIPFTR YDSERGRMEP LTQWIKDSAD PEYWDRVTQI CVGSQHVTAW NLQTVRDRYN QTRDPQTRLQ VYGCDLLSDG SIHGSYRVGY DWWDYISFDL ESKRFLAADN AAEATRRRWE DENEAERWTN YLGHICPEWL QKYVRYGQKE LDRKEPPDVH VSGKEEHGML ILSCHAYGFY PNAIAVNWMK GDEIRDQETE WGGVVPNSDG TFHTWARIEA RPEEREQYRC KVEHPGMPEP GIFAWEPTSG GNLTVVIAVS IVAAIIILAV LIGFVVWRLQ SGRWDRNKYS MAPEKDGGTN GLSAGMERDQ AGIPEGDWER MDRLGSGRDS RSEQGS // ID U3K027_FICAL Unreviewed; 219 AA. AC U3K027; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 23-MAY-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFALP00000008381}; OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; OC Ficedula. OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000008381, ECO:0000313|Proteomes:UP000016665}; RN [1] {ECO:0000313|Ensembl:ENSFALP00000008381} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AGTO01012867; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; U3K027; -. DR Ensembl; ENSFALT00000008419; ENSFALP00000008381; ENSFALG00000008042. DR GeneTree; ENSGT00740000114936; -. DR OMA; VEHESLL; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000016665; Unplaced. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000016665}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000016665}. FT DOMAIN 125 202 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 219 AA; 25568 MW; 13E6B0A69D40C071 CRC64; YWDEQTQRSV GNQHVHAYNL QTARDRYNQT RDPQTNLHVS GCDLLSDGSI HGSYRQAYDW WDYISFDLES KRFLAADNAA EVTRRRWEDE DVAEEFTNYL GHICPEWLQK YVRYGQKELD RKEPPDVHVS GKEEHGMLIL SCHAYGFYPN AIAVNWMKGD EIRDQETEWG GVVPNSDGTF HTWARIEARP EEREQYRCKV EHPGMPEPGI FAWGEAGNV // ID U3KNP3_RABIT Unreviewed; 329 AA. AC U3KNP3; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 12-SEP-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000026852}; GN Name=LOC100328967 {ECO:0000313|Ensembl:ENSOCUP00000026852}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000026852, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Ensembl:ENSOCUP00000026852, ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSOCUP00000026852} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000026852}; RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AAGW02070260; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSOCUT00000033804; ENSOCUP00000026852; ENSOCUG00000010972. DR GeneTree; ENSGT00760000118960; -. DR Proteomes; UP000001811; Chromosome 12. DR Bgee; ENSOCUG00000010972; Expressed in 3 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 329 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004645965. FT TRANSMEM 274 297 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 177 265 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 329 AA; 36499 MW; 3A38FFC46AD38423 CRC64; MGSMAPRTLL LLLAGALTLK DTQAGSHSLS DAENPRMEPR APWMRQVEPE YWDLNTRNAK SHEQTFRVNL NTLRGYYNQS AAGSHTIQWM YGCEVGADGR LLRGYRQDAY DGADYIALNE DLRSWTAADT AAQNTRRKWE AAGAAERQRA YLEGECVEWL RRYLEMGKET LQRADPPKAH VTHHPASDRE ATLRCWALGF YPAEISLTWQ RDGEDQTQDT ELVETRPGGD GTFQKWAAVV VPSGEEQRYT CRVQHEGLPE PLTLTWEPPA QPTALIVGIV AGVLGVLLIL GAVVAVVMRR KHSSDGKGGK YAPAAGGHRD QGSDDSLMP // ID U6BNE9_DANRE Unreviewed; 382 AA. AC U6BNE9; A0A0R4IEH0; DT 22-JAN-2014, integrated into UniProtKB/TrEMBL. DT 22-JAN-2014, sequence version 1. DT 12-SEP-2018, entry version 45. DE SubName: Full=MHC class I antigen ZKA transcript variant 1 {ECO:0000313|EMBL:AHA37402.1}; DE SubName: Full=Major histocompatibility complex class I ZKA {ECO:0000313|Ensembl:ENSDARP00000133584}; GN Name=mhc1zka {ECO:0000313|EMBL:AHA37402.1, GN ECO:0000313|Ensembl:ENSDARP00000133584, GN ECO:0000313|ZFIN:ZDB-GENE-130206-5}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AHA37402.1}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000133584} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000133584}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [2] {ECO:0000313|EMBL:AHA37402.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24287892; DOI=10.1007/s00251-013-0748-z; RA Dirscherl H., Yoder J.A.; RT "Characterization of the Z lineage Major histocompatability complex RT class I genes in zebrafish."; RL Immunogenetics 66:185-198(2014). RN [3] {ECO:0000313|Ensembl:ENSDARP00000133584} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000133584}; RG Ensembl; RL Submitted (NOV-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; KC607870; AHA37402.1; -; mRNA. DR RefSeq; NP_001289174.1; NM_001302245.1. DR Ensembl; ENSDART00000164194; ENSDARP00000133584; ENSDARG00000104293. DR GeneID; 100536229; -. DR KEGG; dre:100536229; -. DR CTD; 100536229; -. DR ZFIN; ZDB-GENE-130206-5; mhc1zka. DR GeneTree; ENSGT00740000114936; -. DR OMA; AYLEENC; -. DR Proteomes; UP000000437; Unplaced. DR Bgee; ENSDARG00000104293; Expressed in 16 organ(s), highest expression level in liver. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 382 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015300683. FT TRANSMEM 329 349 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 218 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 382 AA; 43856 MW; 371C1218F0E3D7E6 CRC64; MMSGGVASGI CALLCVFLLC GDLPSAQGEK HSLYYIYTGL SKPLDLPGIY EFSAMGLLDD RQIDSYNSEE QRKIPKQQWM KEKMQEDYWE KGTQSRKSKE QWFNVNVHIL MDRMRHNKSD LHVLQWRHGC EVEIQGSEVK FSKGVSEYGY DGENLLSFDE TESQWVAPVK EALPTKRKWD NVPILNQYTK GYLEKECVDW LNKFREYADA ELRNGSPPDV YKFTKKSTKD ETKLKLTCLA TGFYPSDVML NIRRNRVYLP EQETISTGVR PNHDQTFQLS KSVEIKEDQI DEYDCSVSHR TFKQPIIIKW DGTDLDGKYT GYPPETVPVV IGSVLILLAI LAVVVFLVMN YDGECCKGLF IHFTLLKDCG LLLPPCGKTE YV // ID UL18_HCMVM Reviewed; 368 AA. AC F5HFB4; DT 11-JUL-2012, integrated into UniProtKB/Swiss-Prot. DT 28-JUN-2011, sequence version 1. DT 23-MAY-2018, entry version 31. DE RecName: Full=Membrane glycoprotein UL18; DE Flags: Precursor; GN Name=UL18; OS Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5). OC Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; OC Betaherpesvirinae; Cytomegalovirus. OX NCBI_TaxID=295027; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15105547; DOI=10.1099/vir.0.79888-0; RA Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L., RA Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C., RA Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., RA Davison A.J.; RT "Genetic content of wild-type human cytomegalovirus."; RL J. Gen. Virol. 85:1301-1312(2004). CC -!- FUNCTION: Plays a role in the protection against host NK cell CC cytotoxicity by interacting with and modulating the activity of CC the host inhibitory leukocyte Ig-like receptor 1/LILRB1, which is CC expressed on monocytes, dendritic cells, as well as subsets of T CC and NK cells. UL18 exerts an inhibitory effect on LIR-1+ NK cells, CC while it stimulates LIR-1- NK cell (By similarity). {ECO:0000250}. CC -!- SUBUNIT: Interacts with host LILRB1. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass CC membrane protein {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AY446894; AAR31583.1; -; Genomic_DNA. DR RefSeq; YP_081477.1; NC_006273.2. DR ProteinModelPortal; F5HFB4; -. DR SMR; F5HFB4; -. DR PRIDE; F5HFB4; -. DR GeneID; 3077466; -. DR KEGG; vg:3077466; -. DR OrthoDB; VOG090000CR; -. DR Proteomes; UP000000938; Genome. DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0039671; P:evasion by virus of host natural killer cell activity; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome; Glycoprotein; Host membrane; KW Host-virus interaction; Immunity; Membrane; MHC I; KW Modulation of host NK-cell activity by virus; Reference proteome; KW Signal; Transmembrane; Transmembrane helix; Viral immunoevasion. FT SIGNAL 1 19 {ECO:0000255}. FT CHAIN 20 368 Membrane glycoprotein UL18. FT /FTId=PRO_0000418297. FT TRANSMEM 326 346 Helical. {ECO:0000255}. SQ SEQUENCE 368 AA; 41730 MW; 3E814AE4A8033A12 CRC64; MMTMWCLTLF VLWMLRVVGM HVLRYGYTGI FDDTSHMTLT VVGIFDGQHF FTYHVNSSDK ASSRANGTIS WMANVSAAYP TYLDGERAKG DLIFNQTEQN LLELEIALGY RSQSVLTWTH ECNTTENGSF VAGYEGFGWD GETLMELKDN LTLWTGPNYE ISWLKQNKTY IDGKIKNISE GDTTIQRNYL KGNCTQWSVI YSGFQTPVTH PVVKGGVRNQ NDNRAEAFCT SYGFFPGEIN ITFIHYGNKA PDDSEPQCNP LLPTFDGTFH QGCYVAIFCN QNYTCRVTHG NWTVEIPISV TSPDDSSSGE VPDHPTANKR YNTMTISSVL LALLLCALLF AFLHYFTTLK QYLRNLAFAW RYRKVRSS // ID V8N129_OPHHA Unreviewed; 87 AA. AC V8N129; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=HLA class I histocompatibility antigen, A-26 alpha chain {ECO:0000313|EMBL:ETE55900.1}; DE Flags: Fragment; GN Name=HLA-A {ECO:0000313|EMBL:ETE55900.1}; GN ORFNames=L345_18391 {ECO:0000313|EMBL:ETE55900.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE55900.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE55900.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE55900.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE55900.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01071242; ETE55900.1; -; Genomic_DNA. DR ProteinModelPortal; V8N129; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 1 86 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE55900.1}. FT NON_TER 87 87 {ECO:0000313|EMBL:ETE55900.1}. SQ SEQUENCE 87 AA; 10718 MW; D61C426A62BDB015 CRC64; MKNFYTSISE PSQGQPQFVA VGYMDGQVFI HYDSHSQRLK PRVSWIEKYV WKEDPQYWER ETRNLRHSEK SFRRNLETLR CRYNQTK // ID V8N197_OPHHA Unreviewed; 122 AA. AC V8N197; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE56034.1}; DE Flags: Fragment; GN Name=MR1 {ECO:0000313|EMBL:ETE56034.1}; GN ORFNames=L345_18256 {ECO:0000313|EMBL:ETE56034.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE56034.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE56034.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE56034.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE56034.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01049010; ETE56034.1; -; Genomic_DNA. DR ProteinModelPortal; V8N197; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 20 74 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE56034.1}. SQ SEQUENCE 122 AA; 14034 MW; 5536229959E4D1C6 CRC64; MECRLLNSTL LLPPSPGSPS HSLYYSYLQL LEPSQGPPQS FIRGYLDDQP IARFDSLTRR MEPLVPWMKE AENQTFLAPE WVFRSDLQKL SKQDHHAGGE QRQGHLWPPM DSGDVMVGFY FP // ID V8N1U7_OPHHA Unreviewed; 130 AA. AC V8N1U7; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE56249.1}; DE Flags: Fragment; GN Name=MR1 {ECO:0000313|EMBL:ETE56249.1}; GN ORFNames=L345_18040 {ECO:0000313|EMBL:ETE56249.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE56249.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE56249.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE56249.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE56249.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01032149; ETE56249.1; -; Genomic_DNA. DR ProteinModelPortal; V8N1U7; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 130 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004770501. FT DOMAIN 13 102 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE56249.1}. SQ SEQUENCE 130 AA; 15172 MW; 0AF00DDD5BB305A4 CRC64; AWGGSLVFLI SLSGLHTWQA ILGCELREDG SKGGFLHYGY DGWDFISFDK ETLRWVTAQP QAQKVKEKWE EDTGWSESNK IFLEETCIER LQRYLSHWKR TLEKTGKPPF MPLAEKKICV YPTPNYRRGK // ID V8N2B3_OPHHA Unreviewed; 88 AA. AC V8N2B3; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETE56409.1}; DE Flags: Fragment; GN ORFNames=L345_17880 {ECO:0000313|EMBL:ETE56409.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE56409.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE56409.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE56409.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE56409.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01023648; ETE56409.1; -; Genomic_DNA. DR ProteinModelPortal; V8N2B3; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 3 77 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE56409.1}. SQ SEQUENCE 88 AA; 10170 MW; C07400D32B875E8B CRC64; PPSHSLSYFY LHLPEPSRGL SQFLIRSYLD DQPIACFDSL TGKMEPLVPW MEEVEEEAFL SPEWVFRTNP KLSKQDLQAG GEQRQCLL // ID V8N2R7_OPHHA Unreviewed; 85 AA. AC V8N2R7; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE56539.1}; DE Flags: Fragment; GN Name=Mr1 {ECO:0000313|EMBL:ETE56539.1}; GN ORFNames=L345_17750 {ECO:0000313|EMBL:ETE56539.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE56539.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE56539.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE56539.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE56539.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01019104; ETE56539.1; -; Genomic_DNA. DR ProteinModelPortal; V8N2R7; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 1 82 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE56539.1}. FT NON_TER 85 85 {ECO:0000313|EMBL:ETE56539.1}. SQ SEQUENCE 85 AA; 9899 MW; 7FBFA431094F157C CRC64; MYGCELQTDG SKRGFAQYGY DGRTFLTFDK ETPAWVAPEP QAQITKRRWD HIPGNNQGVK SYLEETCIEW LEKYLSYGNE TLLRT // ID V8N342_OPHHA Unreviewed; 91 AA. AC V8N342; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETE56073.1}; DE Flags: Fragment; GN ORFNames=L345_18217 {ECO:0000313|EMBL:ETE56073.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE56073.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE56073.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE56073.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE56073.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01044632; ETE56073.1; -; Genomic_DNA. DR ProteinModelPortal; V8N342; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 3 90 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE56073.1}. FT NON_TER 91 91 {ECO:0000313|EMBL:ETE56073.1}. SQ SEQUENCE 91 AA; 10563 MW; CA276581B5583155 CRC64; SSSHSLSIFY TLVLGSNQDV LQYTVVGYVD DQLVSHFDPA TRRMLPQVPW LLNVKKEDLH FWDFISQRVS NTERNLKSDL AILHSYHNSS R // ID V8N351_OPHHA Unreviewed; 78 AA. AC V8N351; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETE56083.1}; DE Flags: Fragment; GN ORFNames=L345_18207 {ECO:0000313|EMBL:ETE56083.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE56083.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE56083.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE56083.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE56083.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01043670; ETE56083.1; -; Genomic_DNA. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 6 77 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE56083.1}. FT NON_TER 78 78 {ECO:0000313|EMBL:ETE56083.1}. SQ SEQUENCE 78 AA; 8951 MW; FF97BDD1435FD932 CRC64; MGSSLDGAQY IVVVYVDDQL AARFDPTTRR LLPQVAWLLD VREEDSHFWD ATSQRVDSTE PSFRNELHVL HIYQNSSG // ID V8N381_OPHHA Unreviewed; 171 AA. AC V8N381; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE55982.1}; DE Flags: Fragment; GN Name=Mr1 {ECO:0000313|EMBL:ETE55982.1}; GN ORFNames=L345_18309 {ECO:0000313|EMBL:ETE55982.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE55982.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE55982.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE55982.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE55982.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01054343; ETE55982.1; -; Genomic_DNA. DR ProteinModelPortal; V8N381; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 17 136 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE55982.1}. SQ SEQUENCE 171 AA; 19713 MW; 1EB5EC738F77423E CRC64; MFTELPPDES VNFQLPKWEK KTKKEDRNRD TKLILPGVLS FCSVSIFSTG FHSWQRVIGC DLSKDGHKRG VYQYGYDGED FISLDQKTLT WTAVDVRAQV TKRRWEAEPF IAQSRNNFLE KECIELLQKC MVYGEDYLLR EGKEGRRGTR VGDVAGELWI CGAKSPCYTS I // ID V8N3S3_OPHHA Unreviewed; 110 AA. AC V8N3S3; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 14. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETE56516.1}; DE Flags: Fragment; GN ORFNames=L345_17773 {ECO:0000313|EMBL:ETE56516.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE56516.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE56516.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE56516.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE56516.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01019719; ETE56516.1; -; Genomic_DNA. DR ProteinModelPortal; V8N3S3; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 65 110 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE56516.1}. FT NON_TER 110 110 {ECO:0000313|EMBL:ETE56516.1}. SQ SEQUENCE 110 AA; 13058 MW; B7D66CDE702210B9 CRC64; MDFISFDKET LRWVTAQPQA QKVKEKWEDD PRWSQGSKVF LEEICIERLQ RYLSYKNKTL EKIEPPVGKV THKVVDERLE VLTCQAFGFY PKEIQAIWTR DGEACVYETL // ID V8N3X3_OPHHA Unreviewed; 86 AA. AC V8N3X3; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=HLA class I histocompatibility antigen, A-66 alpha chain {ECO:0000313|EMBL:ETE56964.1}; DE Flags: Fragment; GN Name=HLA-A {ECO:0000313|EMBL:ETE56964.1}; GN ORFNames=L345_17324 {ECO:0000313|EMBL:ETE56964.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE56964.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE56964.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE56964.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE56964.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01010676; ETE56964.1; -; Genomic_DNA. DR ProteinModelPortal; V8N3X3; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 1 86 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE56964.1}. FT NON_TER 86 86 {ECO:0000313|EMBL:ETE56964.1}. SQ SEQUENCE 86 AA; 10273 MW; 6C72281E9FBA18AC CRC64; MKYFYXXISE PSQGQPHFVA VGYVDGQVFV HYDSHSRKLQ PQVSWMDKVE KDDPQYRDIN NRNFRGSEEM FRVGLETLRS RYNQSE // ID V8N427_OPHHA Unreviewed; 78 AA. AC V8N427; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETE56641.1}; DE Flags: Fragment; GN ORFNames=L345_17648 {ECO:0000313|EMBL:ETE56641.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE56641.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE56641.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE56641.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE56641.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01015850; ETE56641.1; -; Genomic_DNA. DR ProteinModelPortal; V8N427; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 4 77 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE56641.1}. FT NON_TER 78 78 {ECO:0000313|EMBL:ETE56641.1}. SQ SEQUENCE 78 AA; 9164 MW; 386F932A07224B42 CRC64; MGSGQDVPHY IVVAYVDDQL AAHFDPHTQR MLPQMAWLHN MKGEDSHFWD LTSRRVSTTE RRFKTDLAIL HSYYNSSR // ID V8N4D9_OPHHA Unreviewed; 85 AA. AC V8N4D9; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE56427.1}; DE Flags: Fragment; GN Name=Mr1 {ECO:0000313|EMBL:ETE56427.1}; GN ORFNames=L345_17862 {ECO:0000313|EMBL:ETE56427.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE56427.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE56427.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE56427.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE56427.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01022649; ETE56427.1; -; Genomic_DNA. DR ProteinModelPortal; V8N4D9; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 1 82 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE56427.1}. FT NON_TER 85 85 {ECO:0000313|EMBL:ETE56427.1}. SQ SEQUENCE 85 AA; 10181 MW; 79B3CDD9F2CF628C CRC64; MFGCELWRNG SKGGFMQYGY KGRTFITFDK ETLTWVAPDP QAQITQRIWD AIPGYNQRKK AYLEEICIEW LWRYLSYGNE MLLRT // ID V8N4I6_OPHHA Unreviewed; 216 AA. AC V8N4I6; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 20. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE56816.1}; DE Flags: Fragment; GN Name=Mr1 {ECO:0000313|EMBL:ETE56816.1}; GN ORFNames=L345_17472 {ECO:0000313|EMBL:ETE56816.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE56816.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE56816.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE56816.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE56816.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01012080; ETE56816.1; -; Genomic_DNA. DR ProteinModelPortal; V8N4I6; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 216 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004771392. FT DOMAIN 141 216 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE56816.1}. FT NON_TER 216 216 {ECO:0000313|EMBL:ETE56816.1}. SQ SEQUENCE 216 AA; 24868 MW; 5E50E923C1F8F944 CRC64; MALRSAPLWL LVLLAVALRE SCFVSQQGRG ALSLLGTPQT IFLPLFSGLH TLQRMYGCEF CADGTKEGFE MLGYDGSTFL IFDTETRTWV APDPQAQITQ RKWDADTGYN QRIKVYLEEI CIEWLKKHLS YGKEMLQRTE PPGVTVRGKT ESEDGLETHV CRLDGFYPRE IDAFWMRDGE VWLAETFHGF LAPNADGTYH YWLSIRIDPK ERGRYR // ID V8N4P0_OPHHA Unreviewed; 91 AA. AC V8N4P0; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETE56628.1}; DE Flags: Fragment; GN ORFNames=L345_17661 {ECO:0000313|EMBL:ETE56628.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE56628.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE56628.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE56628.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE56628.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01016329; ETE56628.1; -; Genomic_DNA. DR ProteinModelPortal; V8N4P0; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 9 90 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE56628.1}. FT NON_TER 91 91 {ECO:0000313|EMBL:ETE56628.1}. SQ SEQUENCE 91 AA; 10729 MW; 02EBECA22F21EB7A CRC64; SSPRTIHVSY TSATKDCPGL PLFSALAYVD NQLIGRYESH TKKIHSRVDW INTLERKYPK FYNRYTLILQ KDQDDFQENL EMLQKLYNQS G // ID V8N531_OPHHA Unreviewed; 282 AA. AC V8N531; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 17. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE56778.1}; DE Flags: Fragment; GN Name=Mr1 {ECO:0000313|EMBL:ETE56778.1}; GN ORFNames=L345_17510 {ECO:0000313|EMBL:ETE56778.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE56778.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE56778.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE56778.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE56778.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01012730; ETE56778.1; -; Genomic_DNA. DR ProteinModelPortal; V8N531; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 209 282 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE56778.1}. FT NON_TER 282 282 {ECO:0000313|EMBL:ETE56778.1}. SQ SEQUENCE 282 AA; 32559 MW; 7F5AA8F03634F938 CRC64; MTCLSFCVVQ LKSPYSVLRC EAPSSSCPAG SLAGSPRHSL SYSYLKVSEP SQGLPQFLFV LHLDDQPIAQ YDDRTSQMVP LVPWMGAEEA RTLEGPERIF RTDLEWLSKL SHQTEGLHTW QLVLGCELKE DESKGGFLHY AYNGMDFISF DKETLRWVTA QPQAQKVKEK WEDDPRRSQR NIVYLDETCI QKMQKYLSYQ KEALKKTEPP VGKVTRKVVD DSLEVLICQA FGFYPKEIQA IWTRDGEACQ YETLPRNVAP NSDRTYYLWL SIEIDPKERD HF // ID V8N557_OPHHA Unreviewed; 364 AA. AC V8N557; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 18. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE56687.1}; DE Flags: Fragment; GN Name=Mr1 {ECO:0000313|EMBL:ETE56687.1}; GN ORFNames=L345_17601 {ECO:0000313|EMBL:ETE56687.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE56687.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE56687.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE56687.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE56687.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01014628; ETE56687.1; -; Genomic_DNA. DR ProteinModelPortal; V8N557; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 270 359 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE56687.1}. FT NON_TER 364 364 {ECO:0000313|EMBL:ETE56687.1}. SQ SEQUENCE 364 AA; 41725 MW; 3CDBE93F314BE2BA CRC64; MNPPLPTGKG LYDRSHTHRQ LAGNLKGPEE LWEKSNQISQ SRDAGASSSG LKEGTFSSRA ERGRPPCCGC WVTIKVWRGW SCSADPIIFS SSSPGSLSHS LCYFSLRLPE PSQRPPQSFI RGYLDDQHIA HFDSLTRKME PLVPWMEEKK EKETFLISEK VFMADLEKLS KLSHQSEGLH TWQAVWGCEL KEDGSKGGFL HYGYNGTDFI SFDKETLRWV AAQPQAQKVK EKWEEDTWWS KKTKTSWRRP AFSGCRDTCP IRRRLCRGSP PVGKVTHKVV NDNLEVLTCQ AFGFYPKEIQ AIWRRDGEAC QYETLHRNVA PNSDGTYYIL LSIDIDPKER DRFRCHLEHE GLQKPLVLAF KEET // ID V8N5H3_OPHHA Unreviewed; 181 AA. AC V8N5H3; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 14. DE SubName: Full=HLA class I histocompatibility antigen, A-30 alpha chain {ECO:0000313|EMBL:ETE56807.1}; DE Flags: Fragment; GN Name=HLA-A {ECO:0000313|EMBL:ETE56807.1}; GN ORFNames=L345_17481 {ECO:0000313|EMBL:ETE56807.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE56807.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE56807.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE56807.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE56807.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01012237; ETE56807.1; -; Genomic_DNA. DR ProteinModelPortal; V8N5H3; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 79 167 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE56807.1}. SQ SEQUENCE 181 AA; 21543 MW; CB16881BDD63B4FB CRC64; EGRNKRGFLR YGYNRWDIIR FENETLRWGA AQPQAEKVKQ EEDPGWSEKV NVFLEKTCIE WLQRYLSYKN KTEQRTEDPV GKMTRKVVND SLEVLICQAF GFYSKEIQAT WKRDGEVCQY KTLHRNVAPN SDGTYYVWLS IEIDPKQRDH FQCHLKYEGL QEPLVLAWKE KTGERLRGCD V // ID V8N5V2_OPHHA Unreviewed; 474 AA. AC V8N5V2; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 18. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE57689.1}; DE Flags: Fragment; GN Name=Mr1 {ECO:0000313|EMBL:ETE57689.1}; GN ORFNames=L345_16593 {ECO:0000313|EMBL:ETE57689.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE57689.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE57689.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE57689.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE57689.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01007906; ETE57689.1; -; Genomic_DNA. DR Proteomes; UP000018936; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 115 139 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 17 107 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE57689.1}. SQ SEQUENCE 474 AA; 53656 MW; 37A8DD4CFF60E0F2 CRC64; ALVGLRVNSG GAVSAEPPVV TVTRRTEVED GMETHICRQH GFYPREIDAS WTRDGEIWLQ DTFHGSVVPN MDGTYHYWLS VQIDPKERDR YRCHVEHDGL QEPLDVALKE PKSNLGIIIS CIVAALVLVS VIAGILVFFS KYRFFSRRDI KMATKKHQVS DLSFLQVISN LEQGPEAPSL EFVFVLVCVC LNTKESHEAA ELRYLPLPPK NGKMGPIFIT ARLFLGVETP KEELLQVTKD PAVQTRRDKL FRCLQVPGSG GTCLRIAAKD GSALCAPLAP GVGGGGPAGK LLRHSRKLES RVSWMEKVEK EDPNYWVRNT QMARDTEEAS RGDLETLRLR YNQSKSLHTW QRMYGCELRG DGSRGGFDQY GYDGRTFLTF DKEILTWVAP DPQAQISKRK WDASAVYNWR GKSYLEETCI KWLKKHLCYG EETLLRRGEH LDPDWTFFLY GWISLTHSAP LGPWSAVCPA QRLL // ID V8N5V5_OPHHA Unreviewed; 207 AA. AC V8N5V5; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETE56937.1}; DE Flags: Fragment; GN ORFNames=L345_17351 {ECO:0000313|EMBL:ETE56937.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE56937.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE56937.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE56937.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE56937.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01010848; ETE56937.1; -; Genomic_DNA. DR ProteinModelPortal; V8N5V5; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 2 176 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE56937.1}. FT NON_TER 207 207 {ECO:0000313|EMBL:ETE56937.1}. SQ SEQUENCE 207 AA; 24447 MW; 60BC1379EFA1E47A CRC64; SLHSLKHFSI CTSDPSQGQS HFSFLGYVDN QVFVHYESTS QEMQPQVPWV EKAKKENPQL WDKATERVRD SEDLNRAKLE FLRSGYNQSK GFHTLQWMFG CELRGDGSKG GFLQYGYDGR SFITFDKETL TWVAHQPLAE IIKREWDDIP ESNQKWKSYL EEECIQWLQN ILSYGRISKV QRRVHHRLHC DWCCPGMCVC WEFDTLQ // ID V8N5Y8_OPHHA Unreviewed; 365 AA. AC V8N5Y8; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 19. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE57068.1}; DE Flags: Fragment; GN Name=Mr1 {ECO:0000313|EMBL:ETE57068.1}; GN ORFNames=L345_17220 {ECO:0000313|EMBL:ETE57068.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE57068.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE57068.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE57068.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE57068.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01010076; ETE57068.1; -; Genomic_DNA. DR ProteinModelPortal; V8N5Y8; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 293 313 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 190 279 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE57068.1}. SQ SEQUENCE 365 AA; 42847 MW; C98692B44CCC22BE CRC64; GLQEPLVLAW KEETGSFSYS LSYFYLHLSD HSQGLPLSFI RSYLDDQPIV RYESLTRRME PLVPWMEEAE KERFQALEWV FRIDLEELSN LNHQTGGLHT WQATWGCELR EDKGKEWFLH YGYNGMDFIS FDKETLRWVA AQPQAQKVKE KWEDHPGWSQ RKKNYLEYTC IDWLQTYLSY RKEAVQRIEP PVGKVTHKMV DESLEVLTCQ AFGFYPKEIQ ATWTRDGEVC KHETLLRNVA PNSDGTYYVQ LSIDIDPKER DRFQCHLEHE GLQELLVLAW KEERATGWKI RRIGSAVILG AVILFLIGLC WRFRKTLTQK WKSHHHIPSE MVPSPPVDST EDESQPQMML QPKITLEVNL ALAGL // ID V8N6D7_OPHHA Unreviewed; 341 AA. AC V8N6D7; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 28-FEB-2018, entry version 20. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETE57107.1}; DE Flags: Fragment; GN ORFNames=L345_17181 {ECO:0000313|EMBL:ETE57107.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE57107.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE57107.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE57107.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE57107.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01009842; ETE57107.1; -; Genomic_DNA. DR ProteinModelPortal; V8N6D7; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 301 325 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 204 293 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE57107.1}. SQ SEQUENCE 341 AA; 38634 MW; 627BEF63A2EDFE48 CRC64; SSSHSLNIVY FIILEPSQRL SYSIVLGYVD SQIFARYDSN SKKIQPRVSW MEKLEKDIPQ YWQALIDVVR TQDYLFREYL EYMRTAYDMD KVHVRIEMSV SPDDSSNHNP VPLSGFHMLQ GIASVDLQGD GSNRTFMQMA YNGETIASST MDVPITENCI EFLEKCLSYG KEMLLRTAVG GFSACQALEE LRVNSGDAVF AETPMVTLSS RTEVEDGMEM HVCRVDGFYP REIDASWTRD GEVWLQDTLH GSVAPNADGT YHYWLSIQID PEERDRYQCR VEHDGLQEPL DLALKVPGSN LGLIIGCVAI GLVMMCVIVG TSIFLRNHRQ GRGELQRDIS L // ID V8N6K3_OPHHA Unreviewed; 149 AA. AC V8N6K3; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 18. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE57293.1}; DE Flags: Fragment; GN Name=MR1 {ECO:0000313|EMBL:ETE57293.1}; GN ORFNames=L345_16994 {ECO:0000313|EMBL:ETE57293.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE57293.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE57293.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE57293.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE57293.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01008911; ETE57293.1; -; Genomic_DNA. DR ProteinModelPortal; V8N6K3; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 102 149 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE57293.1}. FT NON_TER 149 149 {ECO:0000313|EMBL:ETE57293.1}. SQ SEQUENCE 149 AA; 17619 MW; D048C8D64A3748A5 CRC64; MYGCELPRNR SKGGFLQYGY EGRDFITFNK ETLTWVAPDI QAQITKRKWD ADPEYNQRDK SYLEEECIEW LKKYLSYRKE MLQRTALEEL RVNSGGAVSP EPPGVTMRNR MEAKDGMETH VCRLDGFYPR EINASWTRDG EVWKEETFN // ID V8N6M2_OPHHA Unreviewed; 102 AA. AC V8N6M2; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETE57536.1}; GN ORFNames=L345_16746 {ECO:0000313|EMBL:ETE57536.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE57536.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE57536.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE57536.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE57536.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01008244; ETE57536.1; -; Genomic_DNA. DR ProteinModelPortal; V8N6M2; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 2 79 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 102 AA; 12090 MW; FFE2830BAF039658 CRC64; MMIFCEVGED GKRSGHWQYG YDGRDFLNYD MGTSIWTTAD KEAQEVKQKW ERETAIKQRF TGYLESTCME LLQKNDHYGS KSFLRKEFKK GNEEPKNESS RE // ID V8N7E3_OPHHA Unreviewed; 359 AA. AC V8N7E3; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 18. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE57573.1}; DE Flags: Fragment; GN Name=MR1 {ECO:0000313|EMBL:ETE57573.1}; GN ORFNames=L345_16709 {ECO:0000313|EMBL:ETE57573.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE57573.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE57573.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE57573.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE57573.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01008154; ETE57573.1; -; Genomic_DNA. DR ProteinModelPortal; V8N7E3; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 2. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 256 343 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE57573.1}. SQ SEQUENCE 359 AA; 42147 MW; 6F8730E9F9599012 CRC64; SLLHSLWYSY LQASEPNQGL PHFFSKAYLD DQLIARYDSH TGKVEPLVSW MEKMEKEDPN QGKEGNEMLL TTEQVFRDEL RSIWQNDSPS HSLRYYYLHL PEPSQGLPQF LIRGYLDDQP ITCFDSLTRR GKPLVPWMKE GENENFLALE WVFSADLKKL SQFNHLTEAI LGCELREDGS KGGFLHYGYD GWDFISFDKE TLRWVTAQPQ AQKVKEKWED DPGWSQRNKI YLEKTCIEQL KSYLSYSKEA LQRIEPPVGR VMHKTASEKV DVLICQAFGF YPEEIQAIWR RGEEDCKYET LHRNVAPNSD GTYYVWLSIE IDPKERDLFS CHIKHDSLQE PLVLAWKEDS EEKRQDCGR // ID V8N827_OPHHA Unreviewed; 263 AA. AC V8N827; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 18. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE58429.1}; DE Flags: Fragment; GN Name=Mr1 {ECO:0000313|EMBL:ETE58429.1}; GN ORFNames=L345_15850 {ECO:0000313|EMBL:ETE58429.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE58429.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE58429.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE58429.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE58429.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01006772; ETE58429.1; -; Genomic_DNA. DR ProteinModelPortal; V8N827; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 2. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 154 243 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE58429.1}. FT NON_TER 263 263 {ECO:0000313|EMBL:ETE58429.1}. SQ SEQUENCE 263 AA; 30904 MW; 4D77A547419E065C CRC64; YPLHSLCYSY LYLPEPSQGQ PQYFITGYLD DQAIAHFDSL TRKMKPLVPW MEEEDEKKET FQVLQWAVLG CEPKEDRSKG GFLHYGYDGM DFISFDKEPL RWVIAQPQAQ KVKEQWDVHP GISQRKKFYL EETCIDWLQR YQSSKKKALQ RIEPPVGKVN YNVVNERLEV LTCQAFGFYP KEIQAIWTRD GEACVYETLP RNVAPNSDGT YYVWLSIEID PKERDRFQCH LEHEGLKEPL VLALKKKTGE RLMGLRHAEE NFA // ID V8N9U8_OPHHA Unreviewed; 287 AA. AC V8N9U8; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 18. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE58428.1}; DE Flags: Fragment; GN Name=MR1 {ECO:0000313|EMBL:ETE58428.1}; GN ORFNames=L345_15849 {ECO:0000313|EMBL:ETE58428.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE58428.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE58428.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE58428.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE58428.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01006772; ETE58428.1; -; Genomic_DNA. DR ProteinModelPortal; V8N9U8; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 182 260 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE58428.1}. SQ SEQUENCE 287 AA; 34044 MW; 1AF2F983F242479E CRC64; MLITRPSGPS CGWHSLSYSY FKVSEPTQGL TYFHSVVHLD DHPIARYDSP TRRTVPLVPW METEEVKMPE RMFRADLEWL SNLNHKTEGL HTWQVITSCE LREDGSKGGF LHYGYNGWDF ISFDKETLRW VAAHPQAEKV KEKWEKDPEW SERNKDFLEE TCIEWLQRYL SYQKEVLKKT EPPVGKVTHK VVDDSLEVLT CQAFGFYHKE IQATWRRDGE ACKYETLHRN MAPNSDGTYY VRLSIEIDPR ERNHFQCQLE YKGLQELLVW AFKEETGKKH LQYITSW // ID V8NA65_OPHHA Unreviewed; 186 AA. AC V8NA65; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE59164.1}; DE Flags: Fragment; GN Name=Mr1 {ECO:0000313|EMBL:ETE59164.1}; GN ORFNames=L345_15109 {ECO:0000313|EMBL:ETE59164.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE59164.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE59164.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE59164.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE59164.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01005816; ETE59164.1; -; Genomic_DNA. DR ProteinModelPortal; V8NA65; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 4 172 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE59164.1}. SQ SEQUENCE 186 AA; 21775 MW; 533A31BA7F8517CA CRC64; GSSQHSLYYQ YVVVSEPSKR LPQIIIAGYL DDQLITYYDS QKKEKIPKVS WMKEVDKEDP NYWKDGSDML KATEQVLQKD LTNVQYRYKQ HGGFHTWQTT YGCDVRGNSS IRGYSQYGYD GKTFLSFNKE TLSWMTSEPQ AHITKSNWDA NFEWSQRNKF YLEEECIEWL KKNPSGDSEQ QDGGQG // ID V8NAT1_OPHHA Unreviewed; 319 AA. AC V8NAT1; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 28-FEB-2018, entry version 19. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE59036.1}; DE Flags: Fragment; GN Name=MR1 {ECO:0000313|EMBL:ETE59036.1}; GN ORFNames=L345_15236 {ECO:0000313|EMBL:ETE59036.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE59036.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE59036.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE59036.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE59036.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01005952; ETE59036.1; -; Genomic_DNA. DR ProteinModelPortal; V8NAT1; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 2. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 2. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 137 231 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE59036.1}. SQ SEQUENCE 319 AA; 37609 MW; E306D093DA8E296A CRC64; MSCMGQTQFV EVTYLDSQPI QRYDSNTERM RPLTPWINQA LDQYYWTWES DMGYLKDFLE KLQELHPTVP QNHHNQSTDH TLQCIEGCKL TADGEKIEIH QDALDGKEMK GEEFHSERMY LYGNCIHWLN RYLDMRPQRK ELPIVKVTHQ GVINNLQALT CQAYGFYPKE ISASWRKDGE IFNQTNSSMH IAPNSDGTFN ARLSIQINPK ERKLYRCHVE HVSSSPSVEV TTHMLNVNET LFNCSICNFY PKDIDATWKR DEENWEHGTF HGDTIRNWDG TYCTWISTEI NPMEEYHYFC YVDHEGLQNV LRIEGDKFQ // ID V8NBI9_OPHHA Unreviewed; 266 AA. AC V8NBI9; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 17. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE58937.1}; DE Flags: Fragment; GN Name=Mr1 {ECO:0000313|EMBL:ETE58937.1}; GN ORFNames=L345_15336 {ECO:0000313|EMBL:ETE58937.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE58937.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE58937.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE58937.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE58937.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01006078; ETE58937.1; -; Genomic_DNA. DR ProteinModelPortal; V8NBI9; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 2. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 83 172 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 179 266 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE58937.1}. FT NON_TER 266 266 {ECO:0000313|EMBL:ETE58937.1}. SQ SEQUENCE 266 AA; 31086 MW; 0A7C259A9296762D CRC64; RFWALTTGTK EGFSTNGYNG SNFISFENET WVVAQPQAEK VKEKWVGDPV SSQGNKDYLE KTCIEWLQNY LSYRKKALEY TEPTVGKVTH KEVNDSLKVL ICQVFGFNPK ESRASWRRDG EIWKDKTFLR NMTPNSDGTY YLRLSIEIDP KERDHFRCHL EHKGLQEPLV LALKEEREPP VVEVTCRIQY KSLVTLVCRV YGFYPKEVNV TWRKDGEVWK ENISSAGVLP NSDGTYHTWL RIEVDPEEKR DHYRCYVEHA GLPEPL // ID V8NDF1_OPHHA Unreviewed; 231 AA. AC V8NDF1; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 14. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETE59592.1}; DE Flags: Fragment; GN ORFNames=L345_14677 {ECO:0000313|EMBL:ETE59592.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE59592.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE59592.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE59592.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE59592.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01005441; ETE59592.1; -; Genomic_DNA. DR ProteinModelPortal; V8NDF1; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 2. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 118 191 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE59592.1}. SQ SEQUENCE 231 AA; 27201 MW; 3088DDA10995D5F9 CRC64; MCASFLPVAA TSSHILRYFF TGVSELGHGL PRFVIVGYLD DQQFVHYDSD SQRDLPRGPW IRKLRQDGRK EGNSQFGYDG KDFLSLDKQT LTWTAADWRA QVTKQRWEAD VSYDGLETLI CRLYGFYPKE VDVTWRKGGE ILEHETFRGG ITPNSDRTYH TWLSIEIDPK ERDHYKCHIE HDGLMNPQDF SWEKPGEWLQ WNDEAQKWRK AYEAVSNIVE RRMNLDQKFP C // ID V8NF70_OPHHA Unreviewed; 554 AA. AC V8NF70; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 19. DE SubName: Full=Major histocompatibility complex class I-related protein {ECO:0000313|EMBL:ETE60212.1}; DE Flags: Fragment; GN Name=MR1 {ECO:0000313|EMBL:ETE60212.1}; GN ORFNames=L345_14047 {ECO:0000313|EMBL:ETE60212.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE60212.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE60212.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE60212.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE60212.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01004862; ETE60212.1; -; Genomic_DNA. DR ProteinModelPortal; V8NF70; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.30.500.10; -; 3. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 2. DR Pfam; PF00129; MHC_I; 3. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 2. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS00290; IG_MHC; 2. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 554 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004771529. FT DOMAIN 177 269 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 433 523 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE60212.1}. SQ SEQUENCE 554 AA; 63554 MW; 178F30A56FD6D61E CRC64; MAGKVALRSA PLLSLVWLAV AFPESSFGES PFKDTKDPAR IQGICLTCFA ISEPSQGLPH FVMLGHMDDH VLFRYDSESR KMQPQVSWIE KLQEDDSEFW DKVFKEVRDI ENMLQYGLGI VRILSGYSEG LHMVQVIYSC DLQGDGSKRG FMHMAYNGES ITPPSIMDKS DIEECKPPVV TVTRRVEAED GKETHICRVH GFYPRAVNAS WTRNGEVWLQ DTLHGSVAPN ADGTYHYWLS IQIDPEERGH YQCHVEHNSL QEPLDMALKG IAVWARYFFT SMSDSSQGLP HFVAVGYVDG QVFVHYDSHS RRVQPRVSWM EKVGKEDPQY WDTQTQVVLV NEELFRTNLE IQRGDGSKEG VWQHGYDGRA FLSFDKETLT WVAPDPQAQM SQRKLDTIPG YKHGKKAYLE EVCIEWLEKY LSYGRETLLR TEPPVVTVRG KTEVEDGMEM HVCHVDGFYP REIDASWRRD REVWLQDTFH GSVAPNLDGT YHYWLSIRID PKERGHYRCH VEHDSLLEPL DVSLKGERLQ GGKGWALAGW RVVGEESHSS CFQM // ID V8NFA2_OPHHA Unreviewed; 619 AA. AC V8NFA2; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 17. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETE60318.1}; DE Flags: Fragment; GN ORFNames=L345_13940 {ECO:0000313|EMBL:ETE60318.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE60318.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE60318.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE60318.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE60318.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AZIM01004776; ETE60318.1; -; Genomic_DNA. DR Proteomes; UP000018936; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 2. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 2. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}. FT DOMAIN 406 502 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE60318.1}. SQ SEQUENCE 619 AA; 71696 MW; A726F345166E0C0B CRC64; MKYFYTAISE PSQGLPHFVS VGYMDDQLFS YYDSNSRRVK PQVSWIEKVG KEDPQYWDRN TERSRGDEEV FRENLETLRS RYNQSEGLHT WQNMYGCELW RDGSKGGFDQ YGYEGRTFLS FDKETLTWVA PEPQAQITQR KWDALPGYNQ REKAYLEEIC IEWLEKHLSY GKETLLRTEA RQRWRMGWRR TSAAWMASTP GRSMPPGRGT GRPGCRTPSM GASSHSLKYF STAVSEPSQG LPQYITVGQV DGQVFVHYDS HSRRMQPRVS WIEKVGKEDP QYWERETQRE RGSEETFRET LVTVRSRYNQ SEGLHTWQSM YGCELQADGS KRGFLQYGYD GRTFLTFDKE NLTWMAPDPQ AQITQRKWDA VPGYNQRWKA YLEEECIEWL GRYLSYGNET LLRTEPPVVT VRRKTEVTVR GKREVEDRMV ILVCHVYGFY PNDLIASWMR DGEVLEEDTF RGSLAPNADG TYYYWLSAWI DPNEQAGYQC HVEHVSLKKP LDLALEGERL QGGKAGLFGR LGGGGRGIWP QMCPGWCRCR DQTIELTSGD GNYRIPSQEL ADPDEMPSDP LLGLPCFLPP APEIGFLLFT IPKRLTEFKG QKVTVCCCCK KEVAPYFMI // ID V9GXI4_MOUSE Unreviewed; 114 AA. AC V9GXI4; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 12-SEP-2018, entry version 33. DE SubName: Full=Histocompatibility 2, blastocyst {ECO:0000313|Ensembl:ENSMUSP00000139166}; GN Name=H2-Bl {ECO:0000313|Ensembl:ENSMUSP00000139166, GN ECO:0000313|MGI:MGI:892004}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000139166, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000139166, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000139166, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000139166} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000139166}; RG Ensembl; RL Submitted (DEC-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CT030728; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; V9GXI4; -. DR SMR; V9GXI4; -. DR MaxQB; V9GXI4; -. DR PRIDE; V9GXI4; -. DR Ensembl; ENSMUST00000185087; ENSMUSP00000139166; ENSMUSG00000073406. DR MGI; MGI:892004; H2-Bl. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000073406; Expressed in 157 organ(s), highest expression level in small intestine. DR ExpressionAtlas; V9GXI4; baseline and differential. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 114 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004777095. FT DOMAIN 23 111 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 114 AA; 13249 MW; D138F90DE2C8C047 CRC64; MAQRTLFLLL AAALTMIETR AGPHSMRYFE TAVFRPGLGE PRFISVGYVD NTQFVSFDSD AENPRSEPRA PWMEQEGPEY WERETQIAKD NEQSFGWSLR NLIHYYNQSK GVRL // ID V9GXR0_MOUSE Unreviewed; 257 AA. AC V9GXR0; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 12-SEP-2018, entry version 35. DE SubName: Full=Histocompatibility 2, blastocyst {ECO:0000313|Ensembl:ENSMUSP00000139275}; GN Name=H2-Bl {ECO:0000313|Ensembl:ENSMUSP00000139275, GN ECO:0000313|MGI:MGI:892004}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000139275, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000139275, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000139275, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000139275} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000139275}; RG Ensembl; RL Submitted (DEC-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CT030728; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; V9GXR0; -. DR SMR; V9GXR0; -. DR MaxQB; V9GXR0; -. DR PRIDE; V9GXR0; -. DR Ensembl; ENSMUST00000184502; ENSMUSP00000139275; ENSMUSG00000073406. DR UCSC; uc012ase.1; mouse. DR MGI; MGI:892004; H2-Bl. DR GeneTree; ENSGT00760000118960; -. DR Reactome; R-MMU-1236974; ER-Phagosome pathway. DR Reactome; R-MMU-1236977; Endosomal/Vacuolar pathway. DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR Reactome; R-MMU-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000073406; Expressed in 157 organ(s), highest expression level in small intestine. DR ExpressionAtlas; V9GXR0; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 257 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004776355. FT TRANSMEM 213 236 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 23 200 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 257 AA; 29048 MW; 25CDE770803C833A CRC64; MAQRTLFLLL AAALTMIETR AGPHSMRYFE TAVFRPGLGE PRFISVGYVD NTQFVSFDSD AENPRSEPRA PWMEQEGPEY WERETQIAKD NEQSFGWSLR NLIHYYNQSK GGFHTFQRLS GCDMGLDGRL LRGYLQFAYD GRDYITLNED LKTWMAADLV ALITRRKWEQ AGAAELYKFY LEAECVEWLR RYLQLGKETL LRTEPPPSTG SNMVNIAVLV VLGAVIIIEA MVAFVLKSSR KIAILPGPAG TKGSSAS // ID W5K0S6_ASTMX Unreviewed; 261 AA. AC W5K0S6; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000001186}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000001186, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000001186, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000001186}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000001186} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01064775; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000001186; ENSAMXP00000001186; ENSAMXG00000001165. DR GeneTree; ENSGT00740000114936; -. DR OMA; FIEIHAS; -. DR OrthoDB; EOG091G0BBK; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 217 246 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 121 210 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 261 AA; 30411 MW; 9BE179691BF1AC3B CRC64; SKEQWFKVNV DILMKRMNHN NQDLHVLQWR HGCEIEESNG TVKFLRGIDQ YSYDGSEFLS FDDENMRWIA PVQAAVITKN KWDNVAILNQ YTKGYLEKEC VDWLTKFMEY GKETLRNHSP PKVYAFAKKS LRDPRMLTLT CLATGFYPKD VVMRVRKFGT SFPEHLITSS AVRPNDDGTF QLRKSVEIQE DDKAQFDCCV NHITLTKPII VQWEYRYLLS SATAGITTCV LLIIIAIIVF ICVYFLKKKS EIVTKPWTFV I // ID W5K7L3_ASTMX Unreviewed; 352 AA. AC W5K7L3; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000003574}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000003574, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000003574, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000003574}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000003574} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01120121; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01120122; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000003574; ENSAMXP00000003574; ENSAMXG00000003502. DR GeneTree; ENSGT00740000114936; -. DR OMA; DWINSTA; -. DR OrthoDB; EOG091G0FSD; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 352 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004864269. FT TRANSMEM 321 343 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 223 310 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 352 AA; 39638 MW; 8A2366CA64A20C40 CRC64; MCAEAMKKSN LLCLLLVYLQ QVTMVFTVSD EGPERDSSAD SGSLNLCISV VKTSGFNTIP EYIQKNTLND VTIFHYDSDM DSKMPCPDWI NSTAARREWN YMQFQTDRIS YHITQGFESA VQQFNRTGSL ADRNIYQARG CCVLYPNGTS ASSLTHTFNG KDFIGFDFDR KTFVAPVHEA VVYKHQRETR SSLFNVLHFF GTQCVQNIQL FKTAPAILER KVPEVRIFQQ KKRAGSVTVT CHVTGFYPRE VQVFWLGSDL QPVDEGVTEI LPNGDGTYQT RKSVIVPEED VGKQNYSCVV LHISIPNNIT TVWVGQKCGG FALWIPLVCI SLLACGTGFG VWWRCQTRDA VI // ID W5K7M2_ASTMX Unreviewed; 327 AA. AC W5K7M2; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 23. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000003583}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000003583, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000003583, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000003583}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000003583} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01120124; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01120125; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01120126; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01120127; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01120128; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01120129; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01120130; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01120131; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01120132; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01120133; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000003583; ENSAMXP00000003583; ENSAMXG00000003509. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG090C0HYL; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 327 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004862765. FT TRANSMEM 296 318 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 192 286 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 327 AA; 36924 MW; 8EBB09C9CEDD98BE CRC64; MKYICILLLL LQQVKTDDLR YDSCAYYMVS KGLGLPEFSE RRVLNDVTVY HHDSSLDSKM PCPDWINTTA GKEHWKIIYH WTDYNKYVGT LGLQSATEQF NQTGSLTDGN IYQAFGCCSL YPNGTYRTLL AHAFNGKDFA SFDFQTKTFV AAVPQAVLYK TLREKDPANM EEIATLYKKT CLERLQILKE APRVNIKKVP EVRIIEKKRT GSVTVTCHVT GFYPREVQVI WLGSDLQPVV KGVTEALPND DGTYQTRKSV IVPEEDVGKH TYSCVVLHIS VPNNITTVWE VKAGGVAVWI PLLCISLLAS VIGIGVWWRC KTRDAVI // ID W5K7N4_ASTMX Unreviewed; 204 AA. AC W5K7N4; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 16. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000003595}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000003595, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000003595, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000003595}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000003595} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01120126; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01120127; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000003595; ENSAMXP00000003595; ENSAMXG00000003518. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 204 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004864620. FT DOMAIN 30 187 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 204 AA; 23673 MW; EDCBC98B9DA5AC01 CRC64; MKNANLLFLL LYLQQVTTDL RYDNCCYWMV SKGYDLPEFT ERRVLNEVTV YYHDSSLKSK MPCPDWINTT AGIYEWGQIQ YWSNHNRFVG TLGLQSAINQ FNLTGTLTDR NIYQGFGCCS LYPNGTYSAF LNHAFNGKDF TSFDINSKTF VAAVPQAVVY KTLRESDQTT INYVASYYQK TCLDRLKILK EAPRVRDKRG KINY // ID W5K7P4_ASTMX Unreviewed; 270 AA. AC W5K7P4; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 19. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000003605}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000003605, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000003605, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000003605}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000003605} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01120129; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000003605; ENSAMXP00000003605; ENSAMXG00000003529. DR GeneTree; ENSGT00740000114936; -. DR OMA; PEYTERR; -. DR OrthoDB; EOG090C0HYL; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}. FT DOMAIN 171 258 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 270 AA; 30904 MW; 22F4475E70BC4E3E CRC64; SKGYGLPEYT ERRVLNDVTV YYHVSRQKSK MPCPDWINTT AEKELWGTIH DWTDHNIEIT TLGFQTATQQ FNLTGSLSDR NIYQVTGCCS LYPNGTYTAF MNHAFNGKDF TSFDINTKTF VAAVPQAVRY KTLRESQPLT IDEVAEFYKK TCLERLKMFK QAPEIHRRKD PNVWILQQKK RAGSVTVTCH VTGFYPREVQ VFWLGPDLQP VDEGVTEILP NGDGTYQTRK SVIVPEEDVG KQNYSCVVLH ISVPNNITTV WDVNMTDSED // ID W5K7Q6_ASTMX Unreviewed; 292 AA. AC W5K7Q6; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 19. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000003617}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000003617, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000003617, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000003617}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000003617} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01120138; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000003617; ENSAMXP00000003617; ENSAMXG00000003539. DR GeneTree; ENSGT00740000114936; -. DR OMA; WTENNRY; -. DR OrthoDB; EOG090C0HYL; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}. FT DOMAIN 164 252 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 292 AA; 33676 MW; FE6C275BADBA4B58 CRC64; TFSPKNIRTL ALNDVTVYYH DSSLKSKMPR PDWINTTAGK DMWRIIHDWT ENNRYGGTLQ FHTATQQFNL TDQNIYQASG CCSVYPNGTY TAFLTYAFNE KDFASFDINT KTFVPAVPQA VFYKNLRERD SLRVDMAVKY YKKTCLERLK ILQQDPRVLI RKVPEVQILE QQKKKSGSVT VTCHVTGFYP REVQVFWLGS DLQPVDEXVT EILPNGDGTY QTRKSVIVPE EDVGKQNYSC VVLHISVPNN ITTVWGMIKY YHNVFLMLLT CKTVIICNQA CFILQLEREP VV // ID W5K9F7_ASTMX Unreviewed; 332 AA. AC W5K9F7; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000004218}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000004218, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000004218, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000004218}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000004218} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01062114; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01062115; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01062116; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000004218; ENSAMXP00000004218; ENSAMXG00000004123. DR GeneTree; ENSGT00740000114936; -. DR OMA; TENARWI; -. DR OrthoDB; EOG091G0BBK; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 297 322 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 192 281 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 332 AA; 38340 MW; 0E88AC59E918000D CRC64; ENHFLYYIYT GLSKDLNLKG VYEFTALGLL DDREISFFNG VQQLQDDIKK RTFFNEKQRR TRLKKGTQSR KSKEQWLKDF LDTIIQQMNH SNQDLHVLQW RHGCEIDESS GEVKFLRGIS EYSYDGSDFL YFDYENMRWI AAVPQAEPTK RKWDNETIVN QDAKRYLEKE CVDWLIKFME YGKETLRKHS PPAVYGFAKK SVSDSKKVSL TCLATGFYPK DVDLSVRKFG TSIPDHLITT SGVRPNEDGT YQLRKSAEIS DDPTDYDCNV HHSTIEEPAI KKWEQKCLTN PKTGSGLVLI GGVAGGVIVI LLIVLAVLFF VLKKKRMNGE YK // ID W5KAE8_ASTMX Unreviewed; 378 AA. AC W5KAE8; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000004559}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000004559, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000004559, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000004559}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000004559} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01020690; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_007233552.1; XM_007233490.2. DR Ensembl; ENSAMXT00000004559; ENSAMXP00000004559; ENSAMXG00000004456. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G0BU8; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 19 39 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 309 337 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 378 AA; 42769 MW; 06EE58BAD0973D8D CRC64; MCSMDCLCNT LQWKMIKTLI FLIFTTQLTS ATISLQYYYT GVTPGISFPE FTATGQLNEH QIGYYNTTSQ RVIVTADWIN RSKDEEHWKM MGHHAANDQE LVRVRLANQI MLLNQTEGVH TWQERYVCEL DDDGTRRGYK QFGYDGEDFL SLDVNDEYWT AATPQAVPFK RKWDGLVSIQ KKILETECFE RIKKYVEYGK SVFERKVAPE VSLFQKDSSS PVVCHATGFF PKAVMVSWEK NGEDLNEDVE LRETLPNQDG SFQKRSILTL SPEELNRNKY TCVVQHEGLK KEIILQVSDR RVLSDKGSVG IMVGIIIGVV LAVLLLGILG FAGGLMWKKR KKNSDFSLPV IFTSASAQDS QTPAPTQTPG LDAVAAPH // ID W5KAF1_ASTMX Unreviewed; 359 AA. AC W5KAF1; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000004562}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000004562, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000004562, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000004562}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000004562} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01020690; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000004562; ENSAMXP00000004562; ENSAMXG00000004456. DR GeneTree; ENSGT00740000114936; -. DR OMA; RREPWYL; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 7 30 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 300 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 40705 MW; 62AB2C01CFD49F0F CRC64; NVLTIIVCVI IIVCCVHINL TATISLQYYY TGVTPGISFP EFTATGQLNE HQIGYYNTTS QRVIVTADWI NRSKDEEHWK MMGHHAANDQ ELVRVRLANQ IMLLNQTEGV HTWQERYVCE LDDDGTRRGY KQFGYDGEDF LSLDVNDEYW TAATPQAVPF KRKWDGLVSI QKKILETECF ERIKKYVEYG KSVFERKVAP EVSLFQKDSS SPVVCHATGF FPKAVMVSWE KNGEDLNEDV ELRETLPNQD GSFQKRSILT LSPEELNRNK YTCVVQHEGL KKEIILQVSD RRVLSDKGSV GIMVGIIIGV VLAVLLLGIL GFAGGLMWKK RKKNSVFLSS SLQRWDENQV SLGGGGEKL // ID W5KAQ6_ASTMX Unreviewed; 370 AA. AC W5KAQ6; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000004667}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000004667, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000004667, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000004667}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000004667} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01062705; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01062706; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000004667; ENSAMXP00000004667; ENSAMXG00000004532. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G1XVV; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 317 337 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 211 301 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 370 AA; 41986 MW; EA30A3362B53794C CRC64; ILIKQTKYCC PFLLSCPFST DEHLLEYLYT MQSKNCTIYD CTAVTLLNDR QIDFYNSSSD KPRTAKQNWM KNISESDWKT ITEKLQSDRS LLNKLLDIQM DESGHSNSVS DGHVLQWRHR CAGERQSDGS VTVSRSINEF AYDEEELVNY NCTSNTWYNS DNQNTVLSTS HQVSVSIWMC FNLMSIYQEC FSGLVKFSFF IIRTLKESSA PPAVHVFSKK SVHDSSKQIL TCLATGFYPK DVKMSLRKSG TSLPEHLITS SAVRPNDDET YQLRKSVEIQ EDDPADYDCY VNHSSLQTPV IKQWDKKCSN WTDGRSWTGL IIVLILVVLV FICVLIYKKP QCVKYSSAPS DPGSPDELPS NSNGGVPNGK // ID W5KAR2_ASTMX Unreviewed; 330 AA. AC W5KAR2; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 23. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000004673}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000004673, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000004673, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000004673}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000004673} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01062705; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01062706; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000004673; ENSAMXP00000004673; ENSAMXG00000004532. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 277 297 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 171 261 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 330 AA; 37382 MW; 86394F34C2617C50 CRC64; MQSKNCTIYD CTAVTLLNDR QIDFYNSSSD KPRTAKQNWM KNISESDWKT ITEKLQSDRS LLNKLLDIQM DESGHSNSDG HVLQWRHRCA GERQSDGSVT VSRSINEFAY DEEELVNYNC TSNTWYNSDN QKKEEIEKLS AVLMKKCSQC EEMLKIFLQH STFNITPSQS PPAVHVFSKK SVHDSSKQIL TCLATGFYPK DVKMSLRKSG TSLPEHLITS SAVRPNDDET YQLRKSVEIQ EDDPADYDCY VNHSSLQTPV IKQWDKKCSN WTDGRSWTGL IIVLILVVLV FICVLIYKKP QCVKYSSAPS DPGSPDELPS NSNGGVPNGK // ID W5KCC3_ASTMX Unreviewed; 348 AA. AC W5KCC3; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 21. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000005234}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005234, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000005234, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000005234}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000005234} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01056749; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000005234; ENSAMXP00000005234; ENSAMXG00000005091. DR GeneTree; ENSGT00740000114936; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0BBK; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 293 314 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 277 IGc1. {ECO:0000259|SMART:SM00407}. SQ SEQUENCE 348 AA; 40463 MW; 4EB2B68A47194E70 CRC64; ENHFLYYIYI GLSKDLNVKG LYEFTALGLL DDREIDYYNS KEQKKIPKQS WMMEKMQEDY WEKGTQSRKS KEQWLKDFLD TIIQQMNHSN QDLHVLQWRT GCEIEEFNGT VKFLRGISEY GYDGSDFLSF DIENMRWIAA VPQAEPIMRQ WDNETIVNQD AKDSLEKECV DWLTKFLDDR KETLRNHSSP AVHGFVKKSV RDPKKLTLTC LITGFYPKDV KMSLRKFTTE IPEHLITSSG VRPNDDGTYQ LRKSVEISGD DPTDYDCYLP HSSFKKPVMK KWVNTKNSAG TALIGGAAVG VMVILLGVVL TVLIKKRKND TDRQNLHKGC RNFVYSREET SRSENIEH // ID W5KCE5_ASTMX Unreviewed; 218 AA. AC W5KCE5; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 17. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000005256}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005256, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000005256, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000005256}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000005256} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01056750; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01056751; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01056752; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01056753; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01056754; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01056755; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000005256; ENSAMXP00000005256; ENSAMXG00000005129. DR GeneTree; ENSGT00740000114936; -. DR OMA; EREACPR; -. DR OrthoDB; EOG091G07RC; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 218 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004862617. FT DOMAIN 22 203 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 218 AA; 25920 MW; 76E398929DE2B082 CRC64; MGVSTAVCVL LLNAVFISTL AERHSLYYIY SALNKDVDLP GIYEFTALGL LDDREIDYYN SKEQKKIPKQ SWMMEKMQED YWEKGTQSRK SKEQWFKVNL EILMQRMNHS NQDLHVLQWR TGCEISIYRG EVNFVRGISE YGYDGSDFLY FNDKNMSWIA AVPEAEPIQK KWNEMPILNQ YTLGYQDTEC VDWLLKFLDY RKEFCKLLKY LSIKMIIN // ID W5KCI6_ASTMX Unreviewed; 300 AA. AC W5KCI6; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000005297}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005297, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000005297, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000005297}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000005297} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01037835; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000005297; ENSAMXP00000005297; ENSAMXG00000005172. DR GeneTree; ENSGT00740000114936; -. DR OMA; RDLRSWI; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 249 272 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 145 228 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 300 AA; 34454 MW; 3612FCD61A50CBD1 CRC64; IPKQSWMMEK MQEDYWDKGT LSRKSKEQWF KVNVDILMKR MNHNNTDLHV LQWRHGCEIE ESNGQVKFLR GIDEYSYDGS EFLSFDDENM RWIAPVQAAQ ITKRKWDDVA ILNQYTKGYL EKECVDWLTK FMEYGKESLR KHSAPEVHAF EKKSVTDPGK LTLTCLATGF YPKDVKLCLR KFTTSLPEHM LTSSGIRPND DGTYQLRKSV EIHEDDKAKY DCYVSHSSLP EPVIKPWVPR KSVSAEMGIY IGGGIGALVL LGLIAGVVVF VVKKKGKYRI YTLLRTNDKP PQGSDSTPSS // ID W5KCK1_ASTMX Unreviewed; 322 AA. AC W5KCK1; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000005312}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005312, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000005312, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000005312}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000005312} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01037841; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01037842; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01037843; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01037844; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01037845; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000005312; ENSAMXP00000005312; ENSAMXG00000005186. DR GeneTree; ENSGT00740000114936; -. DR OMA; CEGETHP; -. DR OrthoDB; EOG091G0BBK; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 322 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004862627. FT DOMAIN 210 300 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 322 AA; 36898 MW; 213460F0CDE5C7C0 CRC64; MGVSTAVCVL LLNAVFISTL AERHSLYYIY SALNKDVSLP GIYEFTALGL LDGREIDYYN SKEQKKIPKQ SWMMEKMQED YWEKGTQSRK SKEQWFKVSL ETVMQRMNHS NTDLHVLQWR HGCEIDESNG EVKFLRGISE YGYDGSDFLS FDRQTMTWIA QVPAAVITKM KWDNVAILTQ YTKGYLEKEC VDWLTKFLKF RKESQQKDAP LDVQVFAKPS VSDSSKLTLT CLATGFYPKD ATVIWRRSSS PLSEDLITSS AVRPNDDGTY QLRKSVEILG AEKDQYECYV SHRTLKEPVI KKLGGAPINT DLPEELGMLP PF // ID W5KCM6_ASTMX Unreviewed; 337 AA. AC W5KCM6; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000005337}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005337, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000005337, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000005337}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000005337} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01037846; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01037847; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_007237783.1; XM_007237721.2. DR Ensembl; ENSAMXT00000005337; ENSAMXP00000005337; ENSAMXG00000005212. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G1QZ4; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 337 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004864457. FT TRANSMEM 295 315 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 201 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 337 AA; 38964 MW; 3C11929E5DFCA734 CRC64; MGESEVWVLL VFGVFLPSYG DEHSLYYLHT SQFKHNDSIH EFTALTLLDD VQIDFYNSTD GVRTPKQDWL KEINGSDWER GSAELRDNGQ YLNFLLNKQM MVFGHIESGD HILHWKYGCE AVEHQNGSMT VFSFTNDYSY DGENFISYDW NLQLWSASVK QAYETEKKWN TEHHQNRVLQ TCVDWLKIYL KKSPEIEKKP PVVSMFITSS PPGPNLDSLT CVATGFYPKY LKMILRISGV PISEDQIKST GVRPSGDGTY NLSKTVEVLG HEKFEYDCYV THSSLEEPII KNVRWIYWLV GGVFPLAMII LIVCIHHQEK IMDACEEISW CCCCIEY // ID W5KCN8_ASTMX Unreviewed; 118 AA. AC W5KCN8; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 15. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000005349}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005349, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000005349, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000005349}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000005349} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01037850; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000005349; ENSAMXP00000005349; ENSAMXG00000005228. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG090B0DKT; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}. FT DOMAIN 2 118 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 118 AA; 13876 MW; DAE5F5B731D2EFFE CRC64; MMEKMQEDYW EKGTQSRKSK EQWFKVNVDI LMKRMNHSDP DLHVLQWRHG CEIDESNGTV TFLNGISEYG YDGSDFLSFN NSNKVWVAPV PAAEPFMKKW DAILNQYTQG YLEKECVD // ID W5KD61_ASTMX Unreviewed; 257 AA. AC W5KD61; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 21. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000005522}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005522, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000005522, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000005522}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000005522} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01031158; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_007236172.1; XM_007236110.2. DR Ensembl; ENSAMXT00000005522; ENSAMXP00000005522; ENSAMXG00000005391. DR GeneID; 103022716; -. DR KEGG; amex:103022716; -. DR OrthoDB; EOG091G1LA5; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 257 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004862664. FT DOMAIN 20 187 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 257 AA; 29628 MW; 6ED0E6DA6368F41A CRC64; MIFILLSVYC SVLETTSAEK HTLQYLYTLR SAPEDDTEFE ITTVFDGLII SHCKSPRFRD QSRYDWISQT FTDAEWKNMD LFCESEYYFH KTLKKKIEGV YNTTNGIIQR ERSCTEDDSV VLMSDSWGVN GEDFLTLDPK TLKWSSDTPL ATPVQSGWNQ MKFMTPSLKD FKMYQCKPSL MKLKKKKEEY LKGNLRPKIY IFGKPSHDGD AVSLRCYVSH KYLSGVRVRL TLDGVVVDNI NISSPAPNMD GSVQIRL // ID W5KEE9_ASTMX Unreviewed; 193 AA. AC W5KEE9; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 14. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000005960}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005960, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000005960, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000005960}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000005960} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01059842; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01059843; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000005960; ENSAMXP00000005960; ENSAMXG00000005824. DR OrthoDB; EOG091G07RC; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 193 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004864519. FT DOMAIN 40 181 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 193 AA; 22191 MW; B1BD2A48FF0FCD09 CRC64; MKLLLFLTVT IHLSSAACNR PSHLQFRYTE NTDGETAEAL LDGEQFVYYE KSNETVIPTT EWMKKIENND LVHWGRLTNK LKDGLQSARE LVGTAVSSSN RNEGDHRVEL MYGCKLDKGI ESGYWKFGKY FLSLNLKAGA WTAENNESEP IKQKMEKEGN VQKAFLLNQC ILWLQKYMDC KSNNKTDVKD PRE // ID W5KH17_ASTMX Unreviewed; 268 AA. AC W5KH17; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 22. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000006879}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000006879, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000006879, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000006879}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000006879} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01109883; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01109884; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01109885; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_015463406.1; XM_015607920.1. DR Ensembl; ENSAMXT00000006879; ENSAMXP00000006879; ENSAMXG00000006709. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G0L6E; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 33 {ECO:0000256|SAM:SignalP}. FT CHAIN 34 268 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004865031. FT DOMAIN 47 191 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. FT DOMAIN 208 265 IGc1. {ECO:0000259|Pfam:PF07654}. SQ SEQUENCE 268 AA; 31009 MW; 0E76F591C0592CFF CRC64; MWCLHPKKRW TDRIRTVMLV AVHLLSVFSE SSGVHFHQAT FIYTTRTTIL PKCMATTFTD GLQISYYDSN SKTFKSSWGW VRESMNKSWE LFKNSIYRSM EDLNMTSTLL WSTLEVRKIF QWISNCTWDD KSGDCSGYEK YGRNGKDFIT LDVKKRSYIS HTPEAIHITD LWNKDKARLE SVIHHYTSAC AELVKISVPK LQRAVPPEVY LWQKNSSVVC LATGVYSKTT KVMWQKNSED IHENVDEGET LCNGDGTFQK RSSLRGEA // ID W5KH34_ASTMX Unreviewed; 279 AA. AC W5KH34; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000006896}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000006896, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000006896, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000006896}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000006896} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01109885; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000006896; ENSAMXP00000006896; ENSAMXG00000006716. DR GeneTree; ENSGT00740000114936; -. DR OMA; FARIVDC; -. DR OrthoDB; EOG091G0L6E; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}. FT DOMAIN 195 279 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 279 AA; 32130 MW; 63FFCBF632425725 CRC64; MIYVMILIIG SVRAAQKIYI YSVKYTAAVG ISGLPEFTAT SFLHGKQIDY YDSKDHILLP RKDWAKKILG VPYWEKTTRL RFSESVQLQQ ELSSVMESSG HTEGMHTFQR MYGCLWDGKT GESDGFDVYG YDGENFLSLD VNSRKFTALT PQAKSIVQEW NRNTTRLEVL QLYYKLECVA WLKTFFPEKK GSILKSIKII PTFNHYLKRS YPAAVMCHVR DLSSSSVRMS WQRNEKDFND GFVVIGDTLP SGDGTFQKTI YLYVGVEDLM RNQYKCVLE // ID W5KH56_ASTMX Unreviewed; 342 AA. AC W5KH56; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000006918}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000006918, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000006918, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000006918}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000006918} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01109889; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_007257537.1; XM_007257475.2. DR Ensembl; ENSAMXT00000006918; ENSAMXP00000006918; ENSAMXG00000006739. DR GeneID; 103046005; -. DR KEGG; amex:103046005; -. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G0L6E; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 294 317 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 277 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 342 AA; 39536 MW; 4DE0CCC5C9AE766A CRC64; MKCIHVQRDK QRINPSQLHK KYVLSTMYTV TQVSCQPEFT AVTVVNEQQI TRFDSEHNML IPTQDWVKEA LKDYHWNNYS QIHLSEFARL REELNATMKS LGHTDSVHTF QRRSGCEWDD KTSRVQGFDE YGYDGVDFIS LDLDQMKYVP RTALAKATAE RWNSDDNLLK FQRHYYNTDC SNWLKRIGRV HLKKTGNITF YQKKAFSPVV CHVTGFCPKA MKISWRKNGK DTTKNVSIGD ILPDGEGTYI RDISIFSDEL DVSKFTCVVG DSFKNLSRES LNKPGNSFNT GPNVAVISST VILFTLGFSI TVGFFYFRRR RPDHSRTDEG RSHVEIPLQQ QV // ID W5KH57_ASTMX Unreviewed; 326 AA. AC W5KH57; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000006919}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000006919, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000006919, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000006919}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000006919} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01109889; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000006919; ENSAMXP00000006919; ENSAMXG00000006739. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 292 315 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 207 275 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 326 AA; 37769 MW; 95E58EA905F9AB9D CRC64; MTRPIMLIQQ EEQLYQTEKY VLSTMYTVTQ VSCQPEFTAV TVVNEQQITR FDSEHNMLIP TQDWVKEALK DYHWNNYSQI HLSEFARLRE ELNATMKSLG HTDSVHTFQR RSGCEWDDKT SRVQGFDEYG YDGVDFISLD LDQMKYVPRT ALAKATAERW NSDDNLLKFQ RHYYNTDCSN WLKRIGRVHL KKTGNITFYQ KKAFSPVVCH VTGFCPKAMK ISWRKNGKDT TKNVSIGDIL PDGEGTYIRD ISIFSDELDV SKFTCVVGDS FKNLSRESLN KPGNSFNTGP NVAVISSTVI LFTLGFSITV GFFYFRRRRP ENFKHV // ID W5KLT2_ASTMX Unreviewed; 233 AA. AC W5KLT2; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000008544}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000008544, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000008544, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000008544}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000008544} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01062506; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000008544; ENSAMXP00000008544; ENSAMXG00000008310. DR GeneTree; ENSGT00740000114936; -. DR OMA; GCEMNEN; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}. FT DOMAIN 134 233 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 233 AA; 27259 MW; BC5367BCD9CF824D CRC64; XEDYWEKGTQ SRKSKEQWFK VNLDILMKRM NHSDQDLHVL QWRHGCEVEE SNGEVKFLRG ISEYGYDGSD FLSFNNSDRV WVAPVQAAEE SKRKWDGVAI LNQYTQGYLE KECVDWLTKF MEYGKESLRN HSPPDVHAFA TKSVRDPKKL ILTCLATGFY PKDMEMGLTW FRTSIADHLI TSSGVRPNDD GTYQLRKSVE ILEDDKADYY SYVTHSSFKK PVIIKWGNYI CDW // ID W5KPU4_ASTMX Unreviewed; 221 AA. AC W5KPU4; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 19. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000009606}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000009606, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000009606, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000009606}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000009606} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01065362; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01065363; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01065364; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000009606; ENSAMXP00000009606; ENSAMXG00000009348. DR GeneTree; ENSGT00740000114936; -. DR OMA; NEEQWEL; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}. FT DOMAIN 32 193 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 221 AA; 25273 MW; 203835A5E4784EB7 CRC64; RKCMFLKMYS ISQKLHVASE FITTHLQTSF TIVTPVISIP EFTAVCQVDE EQVGHYDSNN RTVVITADWL KKDKNEEQWE LPSEHVVHQE TLFRTFLAAA LEAFNWTEKE LHTLQRTIGC QLDDDGSKRG YDQFGYDGED LVRLDLNSGT WITVVPQVLP LTQTSSTQLS IQFIQHTCID WLQKCVKYGK SVLERKDPPE VSVFQKNSSS PVVCHATGFF P // ID W5KSZ9_ASTMX Unreviewed; 281 AA. AC W5KSZ9; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000010711}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010711, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000010711, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000010711}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000010711} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01063225; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000010711; ENSAMXP00000010711; ENSAMXG00000010423. DR GeneTree; ENSGT00740000114936; -. DR OMA; WIELEPP; -. DR OrthoDB; EOG091G0BBK; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 232 255 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 129 218 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 281 AA; 32094 MW; 8E684C1FBE6FA749 CRC64; DYWEKGTQSR KSKEQWFKVN VDILMQRMKH NNTDLHVLQW RHGCEIDESN GEVNFLRGIS EYGYDGSDFL YFDNSHRVWV ASVPAAEETK RKWDNLTQNT HDYLEKECVD WLIKFLEYGK ETLRKHSPPD VYVFATKSVR DSKKLRLTCL ATGFYPKDVE LCVRKFGTSL PEHLLTSSGV RPNEDGTYQL RKSMEISGDD PTDYDCYLHH SSLKKPVIKK WVKPNNGSGQ GLIAGAVGGL IVILLILLAV LFFVLRRRRM SGGAGYGQVA YAVPQAPDAQ V // ID W5KY17_ASTMX Unreviewed; 405 AA. AC W5KY17; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000012479}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000012479, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000012479, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000012479}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000012479} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01051203; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01051204; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01051205; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01051206; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01051207; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01051208; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01051209; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000012479; ENSAMXP00000012479; ENSAMXG00000012137. DR GeneTree; ENSGT00740000114936; -. DR OMA; RITQRFY; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 405 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004865392. FT TRANSMEM 303 325 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 405 AA; 44987 MW; 7C59A676E9423F83 CRC64; MGEIIVLKVL LFLTVTVPLS SAASHSLQYF YTAVTPGINF PEFTAVGQVD GEQFMYYDSK ERNAVPKTDW IKKIDRDDAE YWDRETHNLQ GKQETFIANL QTVMQRFNQS KGVHTVQWMY RCELDDDGSK RGYMQCGYDG EDFLSLDLSS LSWIAPVPQA LITKHKWEET GHVLFQKHFL LNECIGWLQK YVEYGRSTLE RKVAPEVSVF QKDSSSPVVC HATGFFPKAV MISWQKNDEE LNEDVELRET LPNQDGTFQK RSILTLSPEE LNRNQYTCVV QHEGLTKKLQ VSDRRVLSGG ESVGIIVGAA MAVLLVIIGC AGVFISKKKT TSGFRLVSGS FSSGSSFRFG SCSNHNSDFI TSSSEDFKSN SNTNSNSSSN TGSNSSSNTG SSSNTGSKST SNSSS // ID W5KY21_ASTMX Unreviewed; 143 AA. AC W5KY21; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000012483}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000012483, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000012483, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000012483}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000012483} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01051204; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000012483; ENSAMXP00000012483; ENSAMXG00000012141. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG090B0DKT; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}. FT DOMAIN 100 143 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 143 AA; 15866 MW; 532E51492496DDB1 CRC64; KCVCVCLCTG LHTLQTTIGC QLDDNGSRRG FAQFGYDGDD LLTLDLKSET WIAAVPQILP FINSSSSAQG TKQFILYQCI DCLLMYVEFG KSVLERKDPP EVSVFQKDSS SSVVCHATGF FPKAVMISWQ KNGEELNEDV ELR // ID W5KY34_ASTMX Unreviewed; 239 AA. AC W5KY34; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 16. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000012496}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000012496, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000012496, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000012496}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000012496} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01051214; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01051215; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01051216; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01051217; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01051218; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000012496; ENSAMXP00000012496; ENSAMXG00000012154. DR GeneTree; ENSGT00740000114936; -. DR OMA; YLENDCI; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 239 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004865397. FT DOMAIN 29 205 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 239 AA; 28128 MW; D189E97C44E251CB CRC64; MCYSVYYRPP GMKLLIFLFT TVHLTSPETH SLQYISTAMT PGTNFPEYTL VGLIDLEPVV YYDSNIRKMI PLVEWMEEKN DKHYWDSETE KQLNVETVFK INLDILMKRF NHAEGIHMLQ RRSGCEWDDY EDDRTKRGYF QFGYDGEDFL SLDLKTETWT AASSKALITK TKWDANVRAT KYRKNYLEND CILWLQRYLG YRKSFLVRKV PPEVSVFQKD SSSPVVCHAT GFFPKAVMI // ID W5KZ78_ASTMX Unreviewed; 238 AA. AC W5KZ78; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000012890}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000012890, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000012890, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000012890}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000012890} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01063204; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01063205; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000012890; ENSAMXP00000012890; ENSAMXG00000012522. DR GeneTree; ENSGT00740000114936; -. DR OMA; EINRCEY; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}. FT DOMAIN 200 238 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 238 AA; 27092 MW; 7D9EBAA5DEBB4B63 CRC64; MEQLILLIVS PQLLVTSMTH SMQYFYTGVT PGINFPEFTS VGLVDGEPFI YYDSDIREDI PKTDWIKKVL DYEAGFFDRQ TQIHQGSQES FKVNVQTAMQ RFNQTKGVHT VQWMYGCELN DDGSVSGYSQ YGYDGEDFVI LDMKTLTWTA PTSEAVVTKH KWEGLGVGAR FKAYMENTCI DWLKKYVGYG RSTLERKVRP EVSLFSSDSS SPVVCHATGF FPKAVMISWQ KNGEDLNE // ID W5L112_ASTMX Unreviewed; 185 AA. AC W5L112; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000013524}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000013524, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000013524, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000013524}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000013524} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01072851; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000013524; ENSAMXP00000013524; ENSAMXG00000013144. DR GeneTree; ENSGT00740000114936; -. DR OMA; VEHESLL; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 185 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004865546. FT DOMAIN 109 185 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 185 AA; 21062 MW; 0ED94F0618DF6140 CRC64; MYSALCVFVC VCVHTGVHTV QRMYGCELDE DGTKRGYFQD GYDGKDFISL DLKTETWTAP VPQAFITKQK WDRTGDAAFQ KAYLETTCIE WLQKYVGYGK ETLERKVAPE VSVFQKSSPS EVVCHATGFF PKAVMISWQK NEEDLNEGVE LRETVPNQDG SFQKRSILTV SPEELKNNQY TCVVQ // ID W5L7R0_ASTMX Unreviewed; 185 AA. AC W5L7R0; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 16. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000015872}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000015872, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000015872, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000015872}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000015872} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01061625; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000015872; ENSAMXP00000015872; ENSAMXG00000015427. DR GeneTree; ENSGT00740000114936; -. DR OMA; WKGILER; -. DR OrthoDB; EOG091G0BBK; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}. FT DOMAIN 1 183 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 185 AA; 22038 MW; C178DCF1D77B6960 CRC64; KHSLFYIYSA LNKDVSLPGI YEFTALGLLD DREIDYYNSK EQKKIHKQNW MIEKMQKDYW EKGTLSRKSK ERWFKVNVDI LMKRMNHNST DLHVLQWRTG CEVEESNGEV KFLNGIDQYS YDGSDFLSFD NSNSVWIAPV QAAEETKRKW DGVAILNQYM QGYLEKECVS WLKKFMEYGK ETLRK // ID W5LDP6_ASTMX Unreviewed; 338 AA. AC W5LDP6; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000017958}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000017958, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000017958, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000017958}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000017958} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01103129; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01103130; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_007254803.1; XM_007254741.2. DR Ensembl; ENSAMXT00000017958; ENSAMXP00000017958; ENSAMXG00000017444. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G0BU8; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 338 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004864305. FT TRANSMEM 306 325 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 338 AA; 38091 MW; A38364002AD75114 CRC64; MEKMKESYIH CVLLLLLLHL LQLSGGEVNS ITAYFIGIQG LNLPDYMERI AVNDVTMFYY DSSMKDEVSC PDWLNTSSGK QHWMDINLIS LHNKHSMATA LKSAILQFNQ TASSSDVNIY QGYGRCSVYP NGTLKALLTH AFNGKDFLTF DVDRKSYIAS VPQAVIYKRQ REANPVWLEI MASFYKKTCF ERLKMFLQHA SVHITKKVPE VHLFKSFKSG SSVLACHVTG FYPKEVQVEW IGAGLQPVDG EVIEVLPNGD GTYQTRRSVI RPEENPEKHS YSCVVQHSSI AGNITKTWVA EEHSLLAVWI SLVCILVIIG TGLVLRKFCR CGQRDTGI // ID W5LDR4_ASTMX Unreviewed; 319 AA. AC W5LDR4; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000017976}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000017976, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000017976, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000017976}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000017976} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01103131; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000017976; ENSAMXP00000017976; ENSAMXG00000017459. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G0BU8; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 319 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004866387. FT TRANSMEM 284 304 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 181 278 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 319 AA; 36560 MW; D9996B156B6E82E0 CRC64; KKTVFFLCFA EFHSFSFFFI ATQGLNFPSY IERVTVDDVT MFYYDSSMTV EPLCPQWLNT TEGLQQWKNM NDRAKYNNHY LSSALESIVK QFNQTETNIY QGYSHCNIFP NGTRKAAFTQ AFRGKDFFSL DIDRKTYVAS VPQAVVYKRQ REANTVLLET VVSFYRTTCF ERLKMFLEHA PEVRVKKGWI FERAESSSSV LTCHVTGFKP KQVQVEWIGA GLQPVDGEIT DMLPNGDGTY QTRRSVIRPR EENPEKHSYS CVVQHSSIGG NITKTWVTET RIRMGVLASL VCIVLAVIGC GLVFRQFCRT KTTCLYPSG // ID W5LIS0_ASTMX Unreviewed; 205 AA. AC W5LIS0; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 23. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000019732}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000019732, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000019732, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000019732}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000019732} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01063063; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000019732; ENSAMXP00000019732; ENSAMXG00000019161. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G1QZ4; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}. FT DOMAIN 98 188 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 205 AA; 23220 MW; 37362F1704E03CBE CRC64; SVSGGHVLHW RHGCEGEQSS DGSLIVLNSI NEFGYDGEDL IQFNCTSKTW ITSVIQKKGE MKKWNTKLRL VKKCVQCEEI LKMYLHYSTA DITQSHTPPA VHIFAKKSVR ESRNLTLACL ITGFDPKDVK MSLRKSGTEI HDHLITSSGI RPNHNGTYQL RKSVEIQEDD SADYYCYVSH SSLTEPVIKK WGKYINLTAL LECKS // ID W5LKI1_ASTMX Unreviewed; 336 AA. AC W5LKI1; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000020343}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000020343, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000020343, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000020343}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000020343} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01061997; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000020343; ENSAMXP00000020343; ENSAMXG00000019749. DR GeneTree; ENSGT00740000114936; -. DR OMA; ADWISEV; -. DR OrthoDB; EOG091G1OOS; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 314 335 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 336 AA; 38658 MW; 333A2963D30ABC1E CRC64; MGTNYPNPTI LEKCIIVLGE HHFFTGKHSL LYLYTMESKN SKSNIYDCTA VTLLNYRQID FYNSTDESRT AKQNWLKNIS ESDWKTSTEK LQNDRQLLNR LLDIQMSEFR HNQSDGHVLQ WRQGCEVDRS LTVVKSISEL AYDGIELIYF NCTSEMWLTS GKPTDRMLEK WNKDYRRTAI KKCEECVRVL EMYLQYRTAN TTDINTTPPA VHVFANKSVR DSRKLTLTCL ITGFYPKDVK MSLRKSGTSL PDHLITSSGI RPNDDGTYQL RESVEIQEDD KAQYDCYVSH SSLQTPVIKK WDGKCRNCTS GRSWTGFIGV AVLVVAGILF ICVLIC // ID W5LMC9_ASTMX Unreviewed; 428 AA. AC W5LMC9; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000020991}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000020991, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000020991, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000020991}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000020991} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01029871; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01029872; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01029873; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01029874; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01029875; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01029876; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01029877; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000020991; ENSAMXP00000020991; ENSAMXG00000020385. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G1QZ4; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 2. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT DOMAIN 302 392 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 428 AA; 48781 MW; E612AAF0519E132E CRC64; VKLSVRKFGT SIPEHLIISS GIRPNDDGTY QLRKSVEISG DDPADYDCYV SHSSLTEPVM KKWDFWMQVT EARSLSCETY KSRKRTKVNT KCESNNNNSA KGAIQHDKHS LLYLYTMQSK NSDSHIYNCT AVTLLNDRQI DFYSSSSDKP RTAKQNWLKN ISESDWKDST EKLQYDRELL NILIVTQMSE FGHSQSGVHV LQWRHGCEGE QSSDGSLTVL NSIASEYIYT DGRGVLQMRY SPSKPTAPAE SQAALGLRSD RIPNLAASKI KYLEKRKCLH CKEMLKIYLQ YKTTDITPSN TPPVVHIFAK KSVRDSRKLI LTCLITGFYP KHVKMSLRKF TTEIPDHLIT SSGIRPNDDE TYQLKKSVEI QEDDPAYYDC YVSHSSLTEP VIKQWGKYNP TLLTYSSVSS AEKREEFVEH VQVAAPLK // ID W5LMD7_ASTMX Unreviewed; 353 AA. AC W5LMD7; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000020999}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000020999, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000020999, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000020999}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000020999} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; APWO01029882; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000020999; ENSAMXP00000020999; ENSAMXG00000020391. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G1QZ4; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 318 343 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 300 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 353 AA; 40645 MW; BF7EF8EC409E3B9B CRC64; MKCYIFKISI RMLKGVFAAM AADNHSLLYL YTMQSKNSYS NIYDCTAVTL LNDRQIDFYS SSSDKPRTAK QNWLKNISES DWIISTEKLQ YDTQLLKSLI DMQLNEFSPN QSDGHVLQWR HGCEGEQSSD GSLTVLNSIN EFGYDGEDLI QFNCTSKTWI TPEENRERER EEKWNKDHQY RADKKCEQCL EMLKMYLKYN TTDITPKHTP PAVFIFAKKS KNDLKKLNLT CLITGFYNRD VKMSLRKLTT EIPDHLITSS GFRLNDDETY QLRKSVEIQE DDSVDYSCYV SHSSLTEPVI KQWVGRCTDC PDNAYQSLII GVVVLGGLAA IYFLILGVLM MIIKQKSGEQ SAC // ID W5LVT1_LEPOC Unreviewed; 352 AA. AC W5LVT1; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLOCP00000000238}; OS Lepisosteus oculatus (Spotted gar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; OC Lepisosteus. OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000000238, ECO:0000313|Proteomes:UP000018468}; RN [1] {ECO:0000313|Ensembl:ENSLOCP00000000238, ECO:0000313|Proteomes:UP000018468} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.; RT "The Draft Genome of Lepisosteus oculatus."; RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLOCP00000000238} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLOCT00000000238; ENSLOCP00000000238; ENSLOCG00000000215. DR GeneTree; ENSGT00740000114936; -. DR OMA; TESWIAP; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000018468; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018468}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018468}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 352 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004865191. FT TRANSMEM 301 322 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 196 274 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 352 AA; 38739 MW; 91050E196B4A6596 CRC64; MMWQLLVVSL CGVQLVSAVT HSLRYFHTGF TGVPGFPEFV AVGMVDDEQI DYYDSVTQKD VPKQQWMKDH MDASYWERQT QKRFGWQQGS NKYALEELPK RFNQTDSKHS SHELSSCLRR GQGCPGQGWT GSCLVSAPGE LCVTKQDVSA LFTVACARQR AVTEDRAECS DLSLTHTQQD SSHLEIGSIS LSPERPQVSV FHKDSRSGGT ELTCLATGFF PRDILVSWLR DGQELQEDVD SGEVLPNGDG SFQVRKSLRV RAGEEDKYSC RVDHKSLSPG DILMPWGEFR GVGHRGKEVP IIAAVCAVVA LAVIAVVAVV LVRRRKSSGG QKPIYRQAAG KEPGDSSSNS SA // ID W5LW58_LEPOC Unreviewed; 337 AA. AC W5LW58; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLOCP00000000365}; OS Lepisosteus oculatus (Spotted gar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; OC Lepisosteus. OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000000365, ECO:0000313|Proteomes:UP000018468}; RN [1] {ECO:0000313|Ensembl:ENSLOCP00000000365, ECO:0000313|Proteomes:UP000018468} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.; RT "The Draft Genome of Lepisosteus oculatus."; RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLOCP00000000365} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLOCT00000000365; ENSLOCP00000000365; ENSLOCG00000000335. DR GeneTree; ENSGT00740000114936; -. DR Proteomes; UP000018468; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018468}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018468}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 281 304 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 175 270 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 337 AA; 38327 MW; 85B73AF1FB0FAE24 CRC64; MSWSFTLTQE AQWIPKFAVV GYLDGLPMEY YDSTHERVVS RRHWRPDPAP AENEEEKKGA AEHTYISMFE KLQLAKKHFN HSGGLHTYQR QAGCELSDDG TQLFHARDAY DGQDLLQYNM DHLRWDPLVP ELKNDEALMH SDDIEQNNTY QPLCIQVLKS YLEQEKDRPV MRVKPRVQVF QKTSALSGGT EVTCLATGFY PRALELTLLR DRRPVPEQEL TGGEVLPNGD GTYQLRKSLA LSKEEEERRE RHRYTCRVQH SGLDNMLEVA REPEPDLDTG LIAGVVIGVL IVALVLPVAA CVLWRKKGRG ACRRSDVKYT EAQGKEQSET SSNSSGP // ID W5LWA2_LEPOC Unreviewed; 345 AA. AC W5LWA2; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLOCP00000000409}; OS Lepisosteus oculatus (Spotted gar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; OC Lepisosteus. OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000000409, ECO:0000313|Proteomes:UP000018468}; RN [1] {ECO:0000313|Ensembl:ENSLOCP00000000409, ECO:0000313|Proteomes:UP000018468} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.; RT "The Draft Genome of Lepisosteus oculatus."; RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLOCP00000000409} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLOCT00000000409; ENSLOCP00000000409; ENSLOCG00000000335. DR GeneTree; ENSGT00740000114936; -. DR OMA; CHIDHAS; -. DR OrthoDB; EOG091G0B7M; -. DR Proteomes; UP000018468; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018468}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018468}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 293 316 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 187 282 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 345 AA; 39065 MW; 9741F725C6A73B32 CRC64; LGFLCATPGT HSMSWSFTLT QEAQWIPKFA VVGYLDGLPM EYYDSTHERV VSRRHWRPDP APAENEEEKK GAAEHTYISM FEKLQLAKKH FNHSGGLHTY QRQAGCELSD DGTQLFHARD AYDGQDLLQY NMDHLRWDPL VPELKNDEAL MHSDDIEQNN TYQPLCIQVL KSYLEQEKDR PVMRVKPRVQ VFQKTSALSG GTEVTCLATG FYPRALELTL LRDRRPVPEQ ELTGGEVLPN GDGTYQLRKS LALSKEEEER RERHRYTCRV QHSGLDNMLE VAREPEPDLD TGLIAGVVIG VLIVALVLPV AACVLWRKKG RGERGREYTE AQGRDQSGPS SNSSG // ID W5LWF3_LEPOC Unreviewed; 370 AA. AC W5LWF3; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLOCP00000000460}; OS Lepisosteus oculatus (Spotted gar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; OC Lepisosteus. OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000000460, ECO:0000313|Proteomes:UP000018468}; RN [1] {ECO:0000313|Ensembl:ENSLOCP00000000460, ECO:0000313|Proteomes:UP000018468} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.; RT "The Draft Genome of Lepisosteus oculatus."; RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLOCP00000000460} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLOCT00000000460; ENSLOCP00000000460; ENSLOCG00000000416. DR GeneTree; ENSGT00740000114936; -. DR OMA; DEGHEYT; -. DR OrthoDB; EOG091G0B7M; -. DR Proteomes; UP000018468; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018468}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018468}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 370 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004866926. FT TRANSMEM 301 324 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 195 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 370 AA; 41692 MW; 6195AD7C8F427B57 CRC64; MKPSALFLLC CGELAWADSH SLWYFMTLTT GPSQFPEFVV VGMVDDVQVE YYDSDVGKVI SRRHWRPDAE VEEADSKVTA AKHYHNSMRN KLQLLMSHLN HTGGHRTYQR IAGCELDDDG SARFGRWDAY DGRDALVYNT QSYSWSLLIP QVVIDKALFQ VNKIRADTFY QPLCVRVLKS YLQQERTRLM RRVKPRVRVF QKTSAFSGGT EVTCLATGFY PRALELTLLR DGRPVPEQEL TGGEVLPNGD GTYQLRKSLA LSEEEEERRG RHRYTCRVQH SGLDNGLEVD WEPEPDLDTG LIVGVVIVVL IVVLVLPVAA CVLWRKKGRG ERERERCGGA QSPACRSSDV KYTAGQGQEQ SETSSNSSGP // ID W5LWS5_LEPOC Unreviewed; 201 AA. AC W5LWS5; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 18. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLOCP00000000582}; OS Lepisosteus oculatus (Spotted gar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; OC Lepisosteus. OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000000582, ECO:0000313|Proteomes:UP000018468}; RN [1] {ECO:0000313|Ensembl:ENSLOCP00000000582, ECO:0000313|Proteomes:UP000018468} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.; RT "The Draft Genome of Lepisosteus oculatus."; RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLOCP00000000582} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLOCT00000000583; ENSLOCP00000000582; ENSLOCG00000000528. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG091G0B7M; -. DR Proteomes; UP000018468; Unassembled WGS sequence. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018468}; KW Reference proteome {ECO:0000313|Proteomes:UP000018468}. FT DOMAIN 1 170 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 201 AA; 23184 MW; 0E2A20A9AFDFC32A CRC64; SHSLWYFLTL TTGPSQFPEF MVVGMVDDVQ VEYYDSDIGK MISRRHWCPD AEVKEADNKE FAVKDFYFGM RDKLQVLMSH LNHTGGHRTY QVIAGCELDD DGSARFGRWD AYNGQDAMNY NMMSYGYTVL IPGVVMDKAR LQVTKFMMDT FYQPLCVRVL KSYLQQERSR LMRRVKPRVR VFQKTSALSG GTEVTCLATG F // ID W5LXF4_LEPOC Unreviewed; 269 AA. AC W5LXF4; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 20. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLOCP00000000811}; OS Lepisosteus oculatus (Spotted gar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; OC Lepisosteus. OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000000811, ECO:0000313|Proteomes:UP000018468}; RN [1] {ECO:0000313|Ensembl:ENSLOCP00000000811, ECO:0000313|Proteomes:UP000018468} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.; RT "The Draft Genome of Lepisosteus oculatus."; RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLOCP00000000811} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLOCT00000000815; ENSLOCP00000000811; ENSLOCG00000000734. DR GeneTree; ENSGT00740000114936; -. DR OMA; TIFVICT; -. DR Proteomes; UP000018468; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018468}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018468}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 223 245 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 96 185 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 269 AA; 29634 MW; 3EBD9640D91BE835 CRC64; APGSHTVLLL CGCELEEDGG GTSRGRCALG HEGKVYLRLD TRTRTWTQVS RAPGAEQGWE PDRSFNRTVL TFLEQYCSQW LKIFIKHTRK TLCRAPAPEA PGLQRGREPN SPVTCSVVSL FPGDVAVSWQ RDGQELTEGV DPAVVLPNGD GSFQVRRSLR VSEEELERHS FTCFVNGTSL GEELVIPWSK REKESGPGLN TGQPLHSIEP SSQNVWMADK NTIFVICTTA FYVLIAALVI CCVTCESGFF KKSTRHQPSA AQREGHTGD // ID W5LXP7_LEPOC Unreviewed; 279 AA. AC W5LXP7; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLOCP00000000904}; OS Lepisosteus oculatus (Spotted gar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; OC Lepisosteus. OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000000904, ECO:0000313|Proteomes:UP000018468}; RN [1] {ECO:0000313|Ensembl:ENSLOCP00000000904, ECO:0000313|Proteomes:UP000018468} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.; RT "The Draft Genome of Lepisosteus oculatus."; RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLOCP00000000904} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLOCT00000000908; ENSLOCP00000000904; ENSLOCG00000000807. DR GeneTree; ENSGT00740000114936; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000018468; Unassembled WGS sequence. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018468}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000018468}. FT DOMAIN 199 279 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 279 AA; 31834 MW; 06B91D9EEDE021B0 CRC64; FSVTGPAHFM IMSLVVPGTH SYQYIYTATV GMSEFPEFVV VGMVDGEQVN YYDSSIKEMI PRREWVKGAV DPDFWNRGTQ ILLGWQQTFK AGIEILRQRF NQTGGVHTWQ LMYGCELDSD GTTRGYFQFG YDGADYISLD KSTLTWTAAN QRAVITKNKW DATGADARFQ TNYLENTCIE WVKKYVEYGR ETLLRTERPQ VSVYSRVSGS QGPEVTCLAT GFFPKDIVVH LQRDGQDLQE DVHSGEVLPN GDGSFQVRKS LRVSEEELKR HQYSCRVDH // ID W5MK52_LEPOC Unreviewed; 327 AA. AC W5MK52; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLOCP00000008761}; OS Lepisosteus oculatus (Spotted gar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; OC Lepisosteus. OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000008761, ECO:0000313|Proteomes:UP000018468}; RN [1] {ECO:0000313|Ensembl:ENSLOCP00000008761, ECO:0000313|Proteomes:UP000018468} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.; RT "The Draft Genome of Lepisosteus oculatus."; RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLOCP00000008761} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSLOCT00000008771; ENSLOCP00000008761; ENSLOCG00000007238. DR GeneTree; ENSGT00740000114936; -. DR OMA; RITQRFY; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000018468; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018468}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018468}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 296 320 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 202 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 327 AA; 37328 MW; 339B8ABAC81F283E CRC64; QIRTRGALCD CCLSVCVFPV THSLRYFYTG VTGVRGFPEF TIVGLVDGQE FVHYDSDIKR MIPKTEWIER NEGKDYWDRQ TQILIGASQV FKTDLVNLPQ RFNQSAGVHT SQSMYGCEWD DEDGTTRGFQ QEGYDGEDYL VFDLKTLTWV APTQRAFLTK QNWDADRAFN EGKKNYLTQI CIEWLKKYVN YGRETLNRRE RPQVSVFHKD SGSGSTELTC LATGFFPRDI LVSWWRDGQE LHEDVDSGEV VPNGDGSFQV RKRLRVRAGE EHKYSCRVDH TSLEKTIVQH WEPPSLVPII AAVCAVVALA VIAVVAVVLV RRRKSSG // ID W5MQ86_LEPOC Unreviewed; 326 AA. AC W5MQ86; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 25-APR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLOCP00000010545}; OS Lepisosteus oculatus (Spotted gar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; OC Lepisosteus. OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000010545, ECO:0000313|Proteomes:UP000018468}; RN [1] {ECO:0000313|Ensembl:ENSLOCP00000010545, ECO:0000313|Proteomes:UP000018468} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.; RT "The Draft Genome of Lepisosteus oculatus."; RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLOCP00000010545} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AHAT01034287; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSLOCT00000010560; ENSLOCP00000010545; ENSLOCG00000008666. DR GeneTree; ENSGT00740000114936; -. DR OMA; ECKLEAN; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000018468; Linkage group LG14. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018468}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Reference proteome {ECO:0000313|Proteomes:UP000018468}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 326 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004866617. FT DOMAIN 199 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 326 AA; 37325 MW; 233C949A61617076 CRC64; MRPFFIFIFF QTLTLPVTAG TFTLRYLYTG VARDVDRFSF SAVLTLNHVP ILFYDSRTGN IVPRQEWLRE AFDSAFWDTE RMRNREQLIV FESTMLLMMQ SFNHTTAEPH TYQRLRECKL EANGDVRVSD RFGYDGTDYL SLDQGTGTWI PAVPQAQSVK QKWDADTART QECRVYLEEE CIQVLKTLIR NGTGALERPV YVEVFQVERE PWEFCCLVTG ISSSGAEVQW VVDQQGVLAE GQSREELLPN GDGSFQVRQV LRVSQQERER HSYACQVNGT LQEPSFPKLR IATEIPLSTN RNDIPCLEMV LVLVTIASIL ALSVLV // ID W5NPL1_SHEEP Unreviewed; 238 AA. AC W5NPL1; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 23-MAY-2018, entry version 19. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000000101}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000000101, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000000101} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSOART00000000126; ENSOARP00000000101; ENSOARG00000000121. DR GeneTree; ENSGT00390000003472; -. DR OMA; FLVHWEE; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000002356; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}. FT DOMAIN 24 192 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 238 AA; 26870 MW; D68626143749D30F CRC64; TEGRRPMGLF LQPCPHLPFA FTDAHSLCYN FTVDSQPRPG QPRCVVQSQV DGNVFLFCDC GRAKIQFTIP LGEEVKTTKA WETQTETLRD VGDLLREQLP DVTSEKHKVT GELESPSAEG AGKGLKLIHC FWVKNKIGQM CLLFDSENGH WTVVHSGGRR MREKWEKDRA VSNFFKKVSM GDCRVWLQDF LVHWEEMSTT TASPTEAPLT VNSTATAIKH TTWILPVLLT SFIITVFL // ID W5NQQ6_SHEEP Unreviewed; 306 AA. AC W5NQQ6; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 23-MAY-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000000496}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000000496, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000000496} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; W5NQQ6; -. DR Ensembl; ENSOART00000000524; ENSOARP00000000496; ENSOARG00000000482. DR GeneTree; ENSGT00760000118960; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000002356; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 252 275 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 157 242 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 306 AA; 34394 MW; C20ACC8FFE4D23D1 CRC64; ISLTMVDYTQ FVRFDSDDPN LRMEARALWM EQEGPEYWDW NMQGIKNTAQ TFGVNLNSLW GYYNQSKVGE QRRPGPQTFR VNLNSLWGYY NQSKVGCLNT GGPAGTFTQP ESASLSANFE ASGDAQHDRN YLEGTCIERL HRFQENRRTH CCARDPPKIH VTHHPISDLE VTLRCWALGF YPEISLTWQH DGEDLTQDTE LVDTRPSGDR SFQKWVALVV PSGEEQRYTC HVQHKGLQEP LTLKWEPPQP SIPIMGITVG LVLLVVAVVS GAVIWKKCSV GGRGGSYVQG ASSDSAQGCD VTFHQS // ID W5NR41_SHEEP Unreviewed; 280 AA. AC W5NR41; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 23-MAY-2018, entry version 18. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000000631}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000000631, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000000631} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSOART00000000661; ENSOARP00000000631; ENSOARG00000000617. DR GeneTree; ENSGT00390000003472; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000002356; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 197 220 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 3 169 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 280 AA; 31485 MW; F21C560AAA2D8C3D CRC64; DAHFLSYNFT IDPRPRDDQP WCEVQGEVDQ KVFLSYDCGR AKVKYLSPLG EEVKSMSTWE TQTVTLRDTF QWKEQLLQER PGPGSGPLTL QARMTCWRES NGHTSVSWEF GFNGQLCLLF DSENGHCTVV HPGGRQMREK WENDRAVTDF FKKVSMGGCR AWLQAFLVRW EKMLKTSASL TMGPSTVQPT APAINHISWI TTGVLTSFVI MGIIITCIHY KKSRRRCSQE APRCSVSLRT QSLLVCLCSP AFTLEPGDET GIQSLPSSYD DAVAAVSCLL // ID W5NR42_SHEEP Unreviewed; 229 AA. AC W5NR42; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 23-MAY-2018, entry version 19. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000000632}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000000632, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000000632} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSOART00000000662; ENSOARP00000000632; ENSOARG00000000617. DR GeneTree; ENSGT00390000003472; -. DR OMA; NISMGDC; -. DR Proteomes; UP000002356; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}. FT DOMAIN 27 194 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 229 AA; 25911 MW; 402E4EFC8C95AEDB CRC64; LSHNWGKGPT FFSPTSPSLC FAFTDAHFLS YNFTIDPRPR DDQPWCEVQG EVDQKVFLSY DCGRAKVKYL SPLGEEVKSM STWETQTVTL RDTKGQMPDV TPEKQTRVGS GPLTLQARMT CWRESNGHTS VSWEFGFNGQ LCLLFDSENG HCTVVHPGGR QMREKWENDR AVTDFFKKVS MGGCRAWLQA FLVRWEKMLK TSECDPSEVS CGRAMARGCP VILLPLPLL // ID W5NRJ8_SHEEP Unreviewed; 256 AA. AC W5NRJ8; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 23-MAY-2018, entry version 19. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000000788}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000000788, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000000788} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSOART00000000820; ENSOARP00000000788; ENSOARG00000000767. DR GeneTree; ENSGT00390000003472; -. DR OMA; GSLICER; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000002356; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 256 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004869725. FT TRANSMEM 233 253 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 35 200 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 256 AA; 28585 MW; 1C5A404A92A919F1 CRC64; LVMGWKAGPG ARLGFAALVL LVAPRFCTAR GDARSFCYNF TVNPQPSPGE LWCVVQGQVD GNVFLSYDCT GAMIQSTSPL GEEVKTMNTW ETQRETLRDI GDFLTGQLPD NITEKPMGSD PLTLQGRMTC WCEEDGRISG SWQFGFNGEM CLRFDSEDGH WTVDHSGGRR IEEKWAKDRA VTDFFKKVSG DCRAWPREFM VHWEKILKSS ASLTTGASTV QPTAPASNHI TEIVLLTIFV ISIVISIVAW IFYKKR // ID W5NSQ3_SHEEP Unreviewed; 335 AA. AC W5NSQ3; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 23-MAY-2018, entry version 32. DE SubName: Full=Hemochromatosis {ECO:0000313|Ensembl:ENSOARP00000001193}; GN Name=HFE {ECO:0000313|Ensembl:ENSOARP00000001193}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000001193, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000001193, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000001193}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000001193} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01059208; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSOART00000001230; ENSOARP00000001193; ENSOARG00000001148. DR GeneTree; ENSGT00740000114936; -. DR OMA; ITMKWLK; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000002356; Chromosome 20. DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl. DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:Ensembl. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl. DR GO; GO:0030881; F:beta-2-microglobulin binding; IEA:Ensembl. DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl. DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro. DR GO; GO:0071281; P:cellular response to iron ion; IEA:Ensembl. DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:Ensembl. DR GO; GO:1904283; P:negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:Ensembl. DR GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; IEA:Ensembl. DR GO; GO:1900121; P:negative regulation of receptor binding; IEA:Ensembl. DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:0002626; P:negative regulation of T cell antigen processing and presentation; IEA:InterPro. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; IEA:Ensembl. DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR GO; GO:1904434; P:positive regulation of ferrous iron binding; IEA:Ensembl. DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl. DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IEA:Ensembl. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:1904437; P:positive regulation of transferrin receptor binding; IEA:Ensembl. DR GO; GO:1900390; P:regulation of iron ion import; IEA:Ensembl. DR GO; GO:2000008; P:regulation of protein localization to cell surface; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR031092; HFE. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF172; PTHR16675:SF172; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 292 313 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 194 283 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 335 AA; 38252 MW; 9F91000ADF70C642 CRC64; SLSPGSHSLR FLFMGASKPD LGLPLFEALG YVDDQLFVSY DHESRRAERR APWLWGRATS QLWLQLSQNL KGWDHMFIVD FWTIMDNHNQ SKVTKPGALP ESHTLQVILG CELREDNSTR GFWKYGYDGQ DYLEFRPETL DWRAAEPRAQ VTKLEWEVNK IRAKQNRAYL DRDCPEQLLH LLELGRGPLE QQVPPLVKVT HHVTSSLTTL RCRALNFYPQ NITIKWLKDK QFLDAKDVKP KDVLPNGDGT YQAWVALAVL PGEEQRYSCH VEHPGLDQPL TATWEPSLSG TLVTGILSGI AVCIIIFLIG ILFRTLRRRQ SSRGAAVNYA LAECE // ID W5NSR9_SHEEP Unreviewed; 355 AA. AC W5NSR9; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 20-JUN-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000001209}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000001209, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000001209} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSOART00000001246; ENSOARP00000001209; ENSOARG00000001165. DR GeneTree; ENSGT00740000114936; -. DR OMA; GREDQCQ; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000002356; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 355 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004868149. FT TRANSMEM 305 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 210 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 355 AA; 39575 MW; AFB74CF7AEBB2D6B CRC64; QTPEMRVTGP RTLLLLLPGA LVLTETWAGE CGVGRKRPLP GGGQDRAGLP GKERARRPRP DLPPPPRPPP PPPGERVTPT LRDPPLPTDP GGAQGDLTWF HFSLDLIPAD GLGGSGSHTL QEMYGCDVEP DGRLLRGYDQ FAYVGREYIT LNEDLSSWTA ADTEAQITKR KWEAAGEAEA RRNYLEGRCV EWLRRYLEKG KDTLLRAEPP KAYVTCHPIS REVTLRCWAL GFYPEEISLT WQRGREDQCQ DMELVETRPS GDGIFQKWAA LVVPSGEEQR YTCRVQHEGL QEPLTLRWEP PQTSFLTMGI IVGLVLLVMV AVVSGAVIWR RKRSDENGRR YTQAASSDSA RGSDV // ID W5NST2_SHEEP Unreviewed; 252 AA. AC W5NST2; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 23-MAY-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000001222}; GN Name=LOC101109080 {ECO:0000313|Ensembl:ENSOARP00000001222}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000001222, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000001222} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSOART00000001261; ENSOARP00000001222; ENSOARG00000001181. DR GeneTree; ENSGT00900000141162; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000002356; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}. FT DOMAIN 146 252 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 252 AA; 27358 MW; 4532C539A3B4EE56 CRC64; MLPSVHPLPG LSSLQTPEMG VMGPRSLLLL LPGALVLTET WAGECGLGRE RPLRGGGQDR AGPPGKERAR RPRPDLSSPH VPSCPSLASR PLFSAPKSWS SSDLLRLPSS SPLPPGSITS DPGPEPRGGR AGSHLSPPSG SHQLRPAQTF RANLNTLRGY YNQSEAGSHT LQEMYGCDVG PDGRLLRGYD QFAYVGREYI TLNEDLSSWT AADTEAQITS TWEKEGEAEA RRNYLEGWCV ESLRRYLEIG KD // ID W5NT66_SHEEP Unreviewed; 244 AA. AC W5NT66; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 23-MAY-2018, entry version 20. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000001356}; GN Name=LOC101105640 {ECO:0000313|Ensembl:ENSOARP00000001356}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000001356, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000001356} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSOART00000001396; ENSOARP00000001356; ENSOARG00000001304. DR GeneTree; ENSGT00390000003472; -. DR OMA; WGKQLEM; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000002356; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}. FT DOMAIN 29 196 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 244 AA; 27330 MW; 4AA0F8FB6A4B1743 CRC64; LLSHKWGEEV MGLLLQNLPS PVFSFTDAHS FCYNFPVDPQ PSPGEPWCVV QGQVDGNAFL SYDCAGAMIQ STSPLGEEVK TMNTWETQRE TLRDIGDFLK GQLPDIILEK DTLGSDPLTL QGRMMCWCEE DGRISGSWQF GFSGEMCLRF DSENGHWTVD HSGGRRIKEK CEKDRAVTDF FKKVSGDCRA WPQEFMVRWE KILKTSASPT TGPSTVQPTA AAIKHITWIL PVVLTSFIIT VFLG // ID W5NT92_SHEEP Unreviewed; 270 AA. AC W5NT92; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 23-MAY-2018, entry version 20. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000001382}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000001382, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000001382} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSOART00000001422; ENSOARP00000001382; ENSOARG00000001329. DR GeneTree; ENSGT00390000003472; -. DR OMA; HLEREVN; -. DR OrthoDB; EOG091G0NI5; -. DR Proteomes; UP000002356; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 270 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004868278. FT TRANSMEM 227 246 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 30 202 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 270 AA; 30093 MW; A95F90D939252183 CRC64; LEGVSLAHTA GRLLLILLLI EPRKTGQDAH PLCLDLTVKS QSRPGQLWCQ VQGSMDTKPF LQYDSDSNKV KPLGFLGKEV NDTKVWTELS ETLAEAGKEL RTVLPVTKLN KKEMNGPPSL QVSLCCQCEA EQCSGASLHF SLNGWTALLL DTMSITWTVI DAGATGIKEE WENNQELAEY FRTISTGDCS YWLREFLKHW ENMLLPEPTV LQPLTKAPNN QPASIPLTKY ILLLIIIFTC LIVIIIKKCM KKSGTTAGEN QAGLWFLGRF // ID W5NUE9_SHEEP Unreviewed; 359 AA. AC W5NUE9; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 23-MAY-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000001793}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000001793, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000001793} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSOART00000001836; ENSOARP00000001793; ENSOARG00000001701. DR GeneTree; ENSGT00760000118960; -. DR OMA; THHHISE; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000002356; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 359 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004868053. FT TRANSMEM 311 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 213 299 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 359 AA; 39236 MW; 030E90C95900FE20 CRC64; MGVMGPRSLL LLLPGALVLT ETWAGECGLG RERPLRGGGQ DRAGPPGKER ARRPRPDLSS PHVPSCPSLA SRPLFSAPKS WSSSDLLRLP SSSPLPPGSI TSDPGPEPRG GRAGSHLSPP SGSHQLRGCG VGPDGRLLRG YSQYGYDGRD YIALNEDLRS WTAADTAAQI SKRKFEQRGA ADRVRHYLNR ECVEGLRRYL ENGKDTLLRA DPPKTHVTHH HISEREVTLR CWALGFYPEE ISLTWQRDGE DQTQDMELVE TRPSGDGTFQ KWAALVVPSG EEQRYTCHVQ HEGLQEPLTL RWEPPQPSVP IIIVVGLLFL VFIGAVVTGA GIWRKRSAGE NAGTYTQASC SDSAQSSDV // ID W5NUL5_SHEEP Unreviewed; 270 AA. AC W5NUL5; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 23-MAY-2018, entry version 19. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000001859}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000001859, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000001859} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSOART00000001906; ENSOARP00000001859; ENSOARG00000001773. DR GeneTree; ENSGT00390000003472; -. DR OMA; CKMWLEE; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000002356; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}. FT DOMAIN 24 190 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 270 AA; 30124 MW; ED7E18A62A337620 CRC64; SLLFCLPLGS PCARSQRGTL CNAHCLCYNF PVDPHPSPGE LWCVIQGQVD GNVYLYDCAG TMIQSTSPLG EEVKTTNTWE TQRETLRDIG DFLKGQLPDI IPEKHAPRDP LTLQGRMTCQ CEEDGHISGS WQFGFKGEMC LCFDSENGHW TVDHSGGRWI KEKWEKDRAV TDFFKKVSGD CRAWLREFMV HWEKMLKTSA PPAMGPSTVQ PMATAVKSKS RILPMLLTSF IITPGLSTFQ EQVLRDLLPG LFGPPQGTVS LRTQSLLGCL // ID W5NVQ0_SHEEP Unreviewed; 250 AA. AC W5NVQ0; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 23-MAY-2018, entry version 18. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000002246}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002246, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000002246} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSOART00000002297; ENSOARP00000002246; ENSOARG00000002135. DR GeneTree; ENSGT00390000003472; -. DR OMA; EANGHTH; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000002356; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}. FT DOMAIN 33 209 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 250 AA; 28825 MW; 48C770D3CEDA6707 CRC64; IGDASHPCFP HWLHRLHQAF PWCLVSWTLS LDTHSLSYNV TIDPRPRDDQ PWCEVRGEVD QNVFLSYDCG RAKIKYMSPL GEEVKSMSTW DMQTVTLRDT ADLLKEQMPD VTPEKQIDKG PGPLTLQARM TCWREDNGGH TSASWEFGFS GQLCLLFDSK NGFWTMVHSK GRRMKEKWEN DRTVTDFFRT VSMGDCWLWY HTFLEHLEKM LKTSASPTTG HPTVKSLATA MMHITWILPV LLTSFIITVP // ID W5NVQ7_SHEEP Unreviewed; 190 AA. AC W5NVQ7; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 20-JUN-2018, entry version 20. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000002253}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002253, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000002253} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSOART00000002304; ENSOARP00000002253; ENSOARG00000002140. DR GeneTree; ENSGT00390000003472; -. DR OMA; MKEDEND; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000002356; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}. FT DOMAIN 13 180 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 190 AA; 21810 MW; AA7E1620B7B5EE84 CRC64; QPCPHLPFAF TDAHSLCYNF TVNSQPRPGQ PWCVVQGQVD GKIFLSYDCG RAKIQFTSPL GEEVKTTKAW ETQTETLRDV GDLLREQLPD VTLENHRVTD PLTLQGRMTC RCEEDGHISG SWQFGFKGEM CLCFDSENGH WTVDHSGGRW IKEKWEKDRA VTDFFKKVSG DCRAWLRGIL VHWEKMLKTS // ID W5NVZ6_SHEEP Unreviewed; 312 AA. AC W5NVZ6; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 20-JUN-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000002342}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002342, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000002342} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR ProteinModelPortal; W5NVZ6; -. DR Ensembl; ENSOART00000002393; ENSOARP00000002342; ENSOARG00000002218. DR GeneTree; ENSGT00740000114936; -. DR OrthoDB; EOG0907079Q; -. DR Proteomes; UP000002356; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 258 279 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 169 241 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 312 AA; 35638 MW; D9DF106DE3495389 CRC64; ISLTMVDYTQ FVRFDSDDPN LRMEARALWM EQEGPEYWDW NMQGIKNTAQ TFGVNLNSLW GYYNQSKVGE QRRPGPRLPQ HGRTRWDLHS ARVGKSFSQF HEGLEYWDWN MQGIKDTAQT FREASGDAQR DKNYLEGTCV ERLHRFQENR RTHCCAQDPP KIHVIHHPSL TLRCWALGFY PEISLTWQHD GEDLTQDTEL VDTRPSGDRS FQKWVALVVP SGEEQRYTCH VQHKGLQEPL TLKWGAFRRT SPRTSIPIMG ITVGLVLLVV AVVSGAVIWK KCSGTEGRGG SYVQAASSSP VGSDQTLEGL KQ // ID W5NX45_SHEEP Unreviewed; 291 AA. AC W5NX45; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 23-MAY-2018, entry version 18. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000002742}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002742, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000002742} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSOART00000002797; ENSOARP00000002742; ENSOARG00000002581. DR GeneTree; ENSGT00390000003472; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000002356; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 202 220 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 3 169 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 291 AA; 32107 MW; DCF863D7CBFB6FC2 CRC64; DAHSFCYNFP VDPQPSPGEP WCVVQGQVDG NAFLSYDCAG AMIQSTSPLG EEVKTMNTWE TQRETLRDIG DFLKGQLPDI ILEKDTWSDP LTLQGRMTCW CEDDGHISGS WKFGFNGEMC LRFDSENGHW TVDHSGRRQI KEMWEKDRAV TDFFKKVSGD CQAWLRDFMV HWRKCVSETT SLTTGASTVQ PTAPASNHKT EIVLGVLPGF VIISIVAWIL SSWTKASFFS AEGGAPRKPN RCSVGLRIQS LPGGLCSPAF TLESGDETGI RSLPSSYDDA VAALSPVSCH I // ID W5NXC1_SHEEP Unreviewed; 302 AA. AC W5NXC1; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 23-MAY-2018, entry version 18. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000002818}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002818, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000002818} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSOART00000002873; ENSOARP00000002818; ENSOARG00000002652. DR GeneTree; ENSGT00390000003472; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000002356; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 227 247 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 24 194 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 302 AA; 33820 MW; A7C59BEC5A4CB3C3 CRC64; KWGEKVMGLL LQNLPSPAFS FTDAHSFCYN FTVDPQPSPG ELWCVVQGQV DGNVFLSYDC TGAMIQSTSP LGEEVKTMNT WETQRETLRD IGDFLTGQLP DNITEKPISL VGSDPLTLQG RMTCWCEEDG RISGSWQFGF NGEMCLRFDS EDGHWTVDHS GGRRIEEKWA KDRAVTDFFK KVSGDCRAWP REFMVHWEKI LKSSASLTTG ASTVQPTAPA SNHITEIVLL TIFVISIVIS IVAWIFYKKR KWCGSRGGAP RKCGRGSVGL RTQSLLGHLC SPAVHFRAKR PHLRNPKSVY QL // ID W5NY10_SHEEP Unreviewed; 348 AA. AC W5NY10; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 23-MAY-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000003057}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000003057, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000003057} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSOART00000003117; ENSOARP00000003057; ENSOARG00000002875. DR GeneTree; ENSGT00760000118960; -. DR OMA; VHEIHER; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000002356; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 348 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004869993. FT TRANSMEM 304 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 294 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 348 AA; 38963 MW; E925F772DCA551DE CRC64; AVMGPRTLLL LLSGALVLAE TRAAPPTLRF FPTAVSRPGL GEPRFIIVGY VDDTQFVRFD SDAPDPRMEP RTRWIEQEGP EYWDEETRIA KDGIVVCVHE IHERHSTQTQ TETSSFSLKE AYFLILKGLK SYCLGFSQIS YDGNNYLVLN EDLCFWTTVD TAAQISKLKP EQGSAVGNSR NYLDGDCGGW LHRHLENGKD TLLRTNPPKA HVTHHPTSER VVTLRCWALG FYPEEISLTW QRNGEDQTQD MELVQTRPSG DGTFQKWAAL VVPSGEEQRY TCHVQHEGLQ EPLTLRWEPP QSSIPIMGIV LVLVLLVVAV VAGAVIWRKK RSGENGQTYT QAASSDGA // ID W5NY41_SHEEP Unreviewed; 280 AA. AC W5NY41; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 15. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000003089}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000003089, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000003089, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000003089}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000003089} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01108337; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSOART00000003149; ENSOARP00000003089; ENSOARG00000002907. DR GeneTree; ENSGT00390000003472; -. DR OMA; VAWILYK; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000002356; Chromosome 8. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 227 246 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 25 195 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 280 AA; 31790 MW; 99048B416D43A30E CRC64; QNWGRRPMGL LLPASPSLRF AFTDAHSLSY TFTVDLQPRH GKLWCEVQGQ VDREVFLSCD CGHAKIIFSS LLGEEVKTIK AWERQVKTLR DIRDWIKDQL HDFTLRKRIA RVGADPLTLK ARMTCCCEDD RHISGSWQFG LNGQMSLHFD LENGHWRVDH PGGRCMKEKW ESDRAVTDFL KVSGDCRAWL QAFMVHWEEM LKTTASPTTV PPTVQPTAPA ISHVTRIAPG VLAIFVITGI VAWILYKKSR RRCSLEAPDR GSVSLRTQSL FGCSSSPVHF // ID W5NY77_SHEEP Unreviewed; 255 AA. AC W5NY77; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 16. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000003125}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000003125, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000003125, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000003125}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000003125} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01108338; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AMGL01108339; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AMGL01108340; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSOART00000003185; ENSOARP00000003125; ENSOARG00000002941. DR GeneTree; ENSGT00390000003472; -. DR OMA; NWENEMD; -. DR OrthoDB; EOG091G0I62; -. DR Proteomes; UP000002356; Chromosome 8. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF00129; MHC_I; 1. DR SUPFAM; SSF54452; SSF54452; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 255 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004868367. FT DOMAIN 29 182 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 255 AA; 28607 MW; E8AD37F0B7A90717 CRC64; MAWIGGSKPR LCFLPLLLFY PFSATPGDAH SLCYNFTINS QPRPGQPWCV VQGQVDGNVF LFCDCGRAKI QFTSPLREEV KTTKAWETQT ETLRDIGDLL REQLPDVTSE KHKVTGRGAD PLTLQGRMTC RCEEDGHISG SWQFGFSGQM CLLFDSENGH WTVVHSGGRR MREKWEKDRA VSNFFKKVSM GDCRLGGNVD NHRDFLLIDS VYNLLKTSAS PTEAPLTVNS TATAIKHTTW ILPVLLTSFI ITVFL // ID W5PBW7_SHEEP Unreviewed; 320 AA. AC W5PBW7; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 20-JUN-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000007928}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000007928, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000007928, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000007928}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000007928} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01092524; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; W5PBW7; -. DR Ensembl; ENSOART00000008045; ENSOARP00000007928; ENSOARG00000007389. DR GeneTree; ENSGT00740000114936; -. DR OMA; RMFGCEI; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000002356; Chromosome 5. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 296 316 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 199 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 320 AA; 36652 MW; 6104C47ED1325687 CRC64; LVVYVNPRPV CVSTGTHSLR YHYLYLSEPG PSLPKFLAVG YVDDQPFIRY DSRVDKAEPQ APWITPMNAK YWEKETKKQR KWAEIHQVET WQTMGYHNHS SVLTGMHSTH RMFGCEIQED GHFNSFWRFG YDGQDHVSLD METLSWVSAN PVALLTKRRI ETEHCYAEYD KAYLEGPCLA SLHRYLELGG QRVTRREPPT VRVTKHSAQD GGTTLRCWAL GFYPQDISLS WWLGEKKLNS KLEYVEPHPS GDGTYQVWMA VWVPAGDETQ YTCHVQHSSL NHTLTVSWEM PSHPGLRAGV ISLILILLVI GGVMSLTKCL // ID W5PGZ6_SHEEP Unreviewed; 369 AA. AC W5PGZ6; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 23. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000009713}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000009713, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000009713, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000009713}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000009713} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01059052; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSOART00000009855; ENSOARP00000009713; ENSOARG00000009042. DR GeneTree; ENSGT00760000118960; -. DR OMA; TETWAGH; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000002356; Chromosome 20. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 369 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004869352. FT TRANSMEM 325 348 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 229 315 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 369 AA; 42148 MW; 065EC71FDF71FA8B CRC64; MRVTEPRTLL LLLSGSLALT ETWAGHIHLG HGDPRPKERR PGWQPLPVPG VHSLRYFHIL VSRPGLGRDL YQSVGYLDDT QFVRYNSETA NPRVEPRAPW MEQGPEYWDR QTNIAREHSQ ASRANLQVIV GNHNHSELES HSFLWLAGCD VRTIRGYEHF AYDGADYITL NEDMRSWSAA GTVAQVIRSK WEVEGAAERY RAYLETECVD WLRKYLEKGK ETLLRAVPPK THVTRHPISD HEVTLRCWAL GFYRAEISLT WQRDGEDQTQ DMELIETRPS GDGTFQKWAA LVVLSGEEQR YTCRVQHEGL QEPLTLRWEP PQTPFLTMGI IVGLVLLLLA VVAGAVLWRK KRSDGDGGSY AQTAREDSI // ID W5PI17_SHEEP Unreviewed; 263 AA. AC W5PI17; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000010085}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000010085, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000010085, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000010085}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000010085} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01059058; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; W5PI17; -. DR Ensembl; ENSOART00000010231; ENSOARP00000010085; ENSOARG00000009395. DR GeneTree; ENSGT00760000118960; -. DR OMA; ECAWIGS; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000002356; Chromosome 20. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 207 231 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 109 195 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 263 AA; 29431 MW; F7B81BB6A43EBEC3 CRC64; FSLGLITAGG RGGSGSHTLQ WVFGCDVGPD GRLLREIWQN AYDGADYISL NEDLRSWTAA DTAAQITKRK WEISGEAEFQ RNYLEGKCVQ WLHRHLETGK DTLLRAEPPK THMTHHRISD HEVTLRCWAL GFYPEEISLT WQRNGEDQTQ DMELVETRPS GDGTFQKWAA LVVPSGEEQR YTCRVQHEGL QEPLTLRWEP PQPSIPIMGI IVGLLLLMVT GAVVTGAVIW WKKHSGEKGQ TYTQASSKDS AQGPDVPLTV PKG // ID W5PIJ0_SHEEP Unreviewed; 372 AA. AC W5PIJ0; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000010259}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000010259, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000010259, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000010259}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000010259} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01059059; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; W5PIJ0; -. DR Ensembl; ENSOART00000010410; ENSOARP00000010259; ENSOARG00000009552. DR GeneTree; ENSGT00760000118960; -. DR OMA; GYCQEAY; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000002356; Chromosome 20. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 31 {ECO:0000256|SAM:SignalP}. FT CHAIN 32 372 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004868977. FT TRANSMEM 317 339 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 219 305 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 372 AA; 41826 MW; E090B26020D21265 CRC64; QTRRMPVMGP RTLLLLLSEV LVLLVLTETW AGSHSLSYFG TCVSRPGLGE QRFIAVGYDG AELARFDSDA PNPRMEPRAP WMEQEGPKYW EEVTQDAKEG QQRSRSGLNT LRGYYNQSEA GERRGPGFNH REWSGAVGPD GRLLHGFWQF AYDGRDYISL NEDLRSWTVA DTAAQITKRK WEISGEAEFQ RNYLEVKCMQ WLHRHLETGK DTLLRADPPR THVAHHPISD REVTLRCWAL GFHPKEMTLT WHRDGEDLTQ DMEAVETRPS GDGTFQKWAA LVVPSGEEQR YTCRVQHEGL QEPLTLRWEP PQPSIPIMGI IVGLVLLMVT GALVTGAVVT KKHSGENGQT YTQAATADSA QGPDVPLTVP KG // ID W5PJ11_SHEEP Unreviewed; 295 AA. AC W5PJ11; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 23-MAY-2018, entry version 23. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000010431}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000010431, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Proteomes:UP000002356}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000010431} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR Ensembl; ENSOART00000010586; ENSOARP00000010431; ENSOARG00000009727. DR GeneTree; ENSGT00900000141162; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000002356; Unplaced. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; SSF54452; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 295 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004868999. FT DOMAIN 128 295 MHC_I-like_Ag-recog. FT {ECO:0000259|Pfam:PF00129}. SQ SEQUENCE 295 AA; 32220 MW; BB8AFD9F52B47830 CRC64; MRVMGLRTLL LLLPGALVLT ETWAGECGLG RERPLRGGGQ DRAGPPGEER PPPPTPLPRP APSPVPACPS LASRPLFSSP LGSSGRSSTS SISLALRPLL PTGSINSDPG PAPGRGRAGS HPSPPPGPHS LRYFLTAVSR PGLGEPRFIA VGYVDDTQFV RFDSDAADPR MEPRARWVER EGPEYWDQET RRTKGAAQTF RANLNTLRGN YNPRGRVSQS PEMYGCHKGP DGRFLRGYMQ FAYYGRDYIA LNEDLRSRTA ADTAAQISKG KMEQRGVADN SRNYLNRECV EGLRR // ID W5PJG5_SHEEP Unreviewed; 376 AA. AC W5PJG5; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000010586}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000010586, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000010586, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000010586}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000010586} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01059059; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSOART00000010743; ENSOARP00000010586; ENSOARG00000009868. DR GeneTree; ENSGT00740000114936; -. DR OMA; CVPCCKK; -. DR OrthoDB; EOG091G0ANY; -. DR Proteomes; UP000002356; Chromosome 20. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 376 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004869203. FT TRANSMEM 306 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 208 296 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 376 AA; 42074 MW; A59A5A5C2A4BA3BF CRC64; MGLSCVWQSL AGAAVFVSLG NAAGEWSSLK SQSGRSPGWF QSGCFAEGYL DHQTFLHYDH KKGRAEPWGR WAEQLEAETW ETESKDLNET WNELGKLLAE ILSLQKEKGG FHSLQETVGC KIPEDSHPRG FRLLHFNREL LLSCSPEAHG CALPQSSAQT LAMEVVKSWD TDGFLSKHYQ AHVQGELCGR LRGYLESWTA FVERTVPPAV NVTRSQDSED MVHLTGKAFG FFPGNISVVW FWDEEPMSRD AQESGGVLPD GNGTYFTWET IKIPQGEEQR VKCIVEHSGN HSAHLSPLGK TLVYQISWWI TSVLVVFIIR FCVCCCIKKR KTASATGRPE SIRLQDLDQF QTEPTDHNGL THPEFQSLCQ TPAPSV // ID W5PLM1_SHEEP Unreviewed; 282 AA. AC W5PLM1; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000011344}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000011344, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000011344, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000011344}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000011344} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01059062; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AMGL01059063; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AMGL01059064; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; W5PLM1; -. DR Ensembl; ENSOART00000011504; ENSOARP00000011344; ENSOARG00000010572. DR GeneTree; ENSGT00760000118960; -. DR OMA; KTHITHH; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000002356; Chromosome 20. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 282 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004869068. FT DOMAIN 206 282 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 282 AA; 32121 MW; B1DFCAD2AAE79BB2 CRC64; MGPRSLLLLL PGALVLTETW AGPSPRTRDP NREEVGPGLT SPRPLLHGFS RDVFFLQVKM QGPTLKLHVS TEWVKMEGTA LRLQVSTKKR DYVFFFERSL NAPCGNYNQS EAGSHTLQEM YGCHVGPDGH LLRGYDQFAY DGRDYLALNE DLSSWTVADT AAQITQRKME QRMAERVRNY LEGECVEWLR RYLETGKDTL QRADPPKAHV THHPISGHDV TLRCWALGFY PEEISLTWQR NGEDQTQDME LVQTRPSGDG TFQKWAALVV PSGEEQRYTC HV // ID W5PUL5_SHEEP Unreviewed; 354 AA. AC W5PUL5; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 26. DE SubName: Full=IgG receptor FcRn large subunit p51 precursor {ECO:0000313|Ensembl:ENSOARP00000014147}; GN Name=FCGRT {ECO:0000313|Ensembl:ENSOARP00000014147}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000014147, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000014147, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000014147}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000014147} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01029330; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSOART00000014354; ENSOARP00000014147; ENSOARG00000013202. DR GeneTree; ENSGT00740000114936; -. DR OMA; PWISLRG; -. DR OrthoDB; EOG091G0KJB; -. DR Proteomes; UP000002356; Chromosome 14. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019864; F:IgG binding; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 354 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004869886. FT TRANSMEM 299 320 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 201 288 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 354 AA; 38993 MW; 9AC2ED2DFCB699A3 CRC64; PRARGVAAWG LGLFLVLLPG ALSAENHRSL QYHFTAVSAP AAGTPAFWVS GWLGPQQYLS YNNLRAQAEP YGAWVWESQV SWYWEKETTD LRNQEKLFLQ ALQVLGEGPF TLQGLLGCEL GPDNVSVPVA KFALNGEEFM MFDPKLGIWD GDWPESRTVS IQWTKQPEAV NKEKTFLLYS CPHRLLGHLE RGRGNLEWKE PPSMRLKARP SSPGLSVLTC SAFSFYPPEL KLHFLRNGLA IGSGEIDMGP NGDGSFYAWS SLTVKSGDEH HYRCVVQHAG LAQPLTVELE SPARTSMPVV GIVIGFFLLL TVAAGGALLW RRMRKGLPAS WISFRGEDVG ALLPTPGLSK DGES // ID W5PWM7_SHEEP Unreviewed; 380 AA. AC W5PWM7; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 20-JUN-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000014860}; GN Name=LOC101107908 {ECO:0000313|Ensembl:ENSOARP00000014860}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000014860, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000014860, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000014860}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000014860} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01059082; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_011956355.1; XM_012100965.2. DR ProteinModelPortal; W5PWM7; -. DR Ensembl; ENSOART00000015080; ENSOARP00000014860; ENSOARG00000013856. DR GeneID; 101107908; -. DR GeneTree; ENSGT00740000114936; -. DR OMA; TSRMKIF; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000002356; Chromosome 20. DR ExpressionAtlas; W5PWM7; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 337 360 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 241 327 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 380 AA; 43665 MW; F82802A28101EF1C CRC64; MRENPVFFQF GSCDLSFSAG VDSACMETPD SCVITSLLSS PVAGIFAGSH SLRYFYSVVS EPGPGVPLFM ASGFVDNQPF IRYDSEEMKA KSCVHWLREE PSYFDDETKI FTSRMKIFHL NLRNVQQYYN QTKEDGLNRA LAQKQTSPHT LQFTYGCELL EDGRTTWHWR YGYDGEDYLS LHMDPLQYTA ATFVAQYTKQ KWEAAGNFIE RDKNYLEKEC ILWLWRYLTF GGESLNRTEP PKTHMTHHRI SDHEVTLRCW ALGFYPEEIS LTWQRNGEDQ TQDMELVETR PSGDGTFQKW AALVVPSGEE QRYTCRVQHE GLQEPLTLRW EPPQTSFLTM GIIVGLVLLV VAVAAGAVIW RRKRSGTESA HSGTKFVMLF // ID W5PWM8_SHEEP Unreviewed; 353 AA. AC W5PWM8; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 20-JUN-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000014861}; GN Name=LOC101107908 {ECO:0000313|Ensembl:ENSOARP00000014861}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000014861, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000014861, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000014861}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000014861} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01059082; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_004019325.2; XM_004019276.3. DR Ensembl; ENSOART00000015081; ENSOARP00000014861; ENSOARG00000013856. DR GeneID; 101107908; -. DR KEGG; oas:101107908; -. DR GeneTree; ENSGT00740000114936; -. DR KO; K06751; -. DR Proteomes; UP000002356; Chromosome 20. DR ExpressionAtlas; W5PWM8; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 353 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004871066. FT TRANSMEM 310 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 300 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 353 AA; 41173 MW; 63C82FD7EE0C269B CRC64; MLWGSVLLNF FLAYLPETQT RSHSLRYFYS VVSEPGPGVP LFMASGFVDN QPFIRYDSEE MKAKSCVHWL REEPSYFDDE TKIFTSRMKI FHLNLRNVQQ YYNQTKEDGL NRALAQKQTS PHTLQFTYGC ELLEDGRTTW HWRYGYDGED YLSLHMDPLQ YTAATFVAQY TKQKWEAAGN FIERDKNYLE KECILWLWRY LTFGGESLNR TEPPKTHMTH HRISDHEVTL RCWALGFYPE EISLTWQRNG EDQTQDMELV ETRPSGDGTF QKWAALVVPS GEEQRYTCRV QHEGLQEPLT LRWEPPQTSF LTMGIIVGLV LLVVAVAAGA VIWRRKRSGT ESAHSGTKFV MLF // ID W5PXC6_SHEEP Unreviewed; 364 AA. AC W5PXC6; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000015110}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015110, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000015110, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015110}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000015110} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01059082; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; W5PXC6; -. DR Ensembl; ENSOART00000015330; ENSOARP00000015110; ENSOARG00000014069. DR GeneTree; ENSGT00760000118960; -. DR OMA; DEICAPW; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000002356; Chromosome 20. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 364 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004869579. FT TRANSMEM 307 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 212 298 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 364 AA; 41056 MW; D9D8546AF7692D1B CRC64; PRGCGVMGPR TLLQLLSGIL VLTKTLGGPH SLRYVYTAVS RPGLGEPRFI AVGYVDDTQF VRFDSDAPNP RMEPRARWVE QEGPEYWDLN TRRTKDAAQT FRANLNNLRG YYNQSEAGSH TLQVIYGCDV GPDGRLLHGY DQFAYDGREY IALNEDLRSW TAADTAAQIS KRKFEQRGAA DRVRHYLNRE CVEGLRRYLE NGKDTLLRAD PPKAHVTHHL ISKRVVTLRC WALGFYPEEI SLTWQRSGED QTQDMQLVET RPSGDGTFQK WAALVVPSGE EQRYTCHVQH EGLQEPLTLR WQPPQTLFLT MCITVGLVLL MVAVVAGAVI WTCMKMGEKR RTYIQAASSD SAQDSDVPLA VPKG // ID W5PYL7_SHEEP Unreviewed; 366 AA. AC W5PYL7; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000015551}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015551, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000015551, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015551}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000015551} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00291881}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01059085; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AMGL01059086; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; W5PYL7; -. DR Ensembl; ENSOART00000015779; ENSOARP00000015551; ENSOARG00000014493. DR GeneTree; ENSGT00760000118960; -. DR OMA; FDSYTAN; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000002356; Chromosome 20. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00447792}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004869614. FT TRANSMEM 310 333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 214 300 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 366 AA; 40956 MW; C98DCBA8739A3910 CRC64; AVMGPRTLLL LLSGALVLAE TRAAPPTLRF FPTAVSRPGL GEPRFIIVGY VDDTQFVRFD SDAPDPRMEP RTRWIEQEGP EYWDEETRIA KDGITQTETS SFSLKEAYFL ILKAKTSNTY LGVNCNPRQN LRSQQKSYCL GFSQISYDGN NYLVLNEDLC FWTTVDTAAQ ISKLKPEQGS AVGNSRNYLD GDCGGWLHRH LENGKDTLLR TNPPKAHVTH HPTSERVVTL RCWALGFYPE EISLTWQRNG EDQTQDMELV QTRPSGDGTF QKWAALVVPS GEEQRYTCHV QHEGLQEPLT LRWEPPQSSI PIMGIVLVLV LLVVAVVAGA VIWRKKRSGE NGQTYTQAAS KYRGEGSDVS LTVPKG // ID W5Q082_SHEEP Unreviewed; 368 AA. AC W5Q082; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000016118}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000016118, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000016118, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000016118}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000016118} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01059091; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; W5Q082; -. DR Ensembl; ENSOART00000016352; ENSOARP00000016118; ENSOARG00000015002. DR GeneTree; ENSGT00760000118960; -. DR OMA; HIFQRIH; -. DR OrthoDB; EOG091G09OH; -. DR Proteomes; UP000002356; Chromosome 20. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 312 335 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 220 276 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 368 AA; 41122 MW; 168B02C8D02CF49B CRC64; LPLGTRFLEK PISFSVDPGY KVLLSGVLVL TEIRAGPHSL RYVYTAVSRP GLGEPRFIAV GYVDDTQFVR FDSDARNPRM EPRARWMEQE GPEYWDQETQ GIKDAALTFR ANLNTALGYY NQSEAGSHTV QRMYGCDVGP DGRLLRGYSQ YGYDGRDYIA LNEDLRSWTA ADTAAQVTQR NAEAAGEAAR VRIYLEGKCV EWLRRYLETG KDTLLRADPP KAHVTHHPIS GHDVTLRCWA LGFYPEEISL TWQRNGEDQT QDMELVETRP SGDGTFQKWA ALVVPSGEGQ RYQHEGLQEP LTLRWEPPQT SFLTMGIIVG LVLLVVAVVA GAVIWRKKHS GEKRGTYTQA SSNDSAQGSD VSLTVHKG // ID W5Q9A2_SHEEP Unreviewed; 313 AA. AC W5Q9A2; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 23-MAY-2018, entry version 32. DE SubName: Full=Alpha-2-glycoprotein 1, zinc-binding {ECO:0000313|Ensembl:ENSOARP00000019294}; GN Name=AZGP1 {ECO:0000313|Ensembl:ENSOARP00000019294}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000019294, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000019294, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000019294}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000019294} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01069487; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AMGL01069488; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PRIDE; W5Q9A2; -. DR Ensembl; ENSOART00000019562; ENSOARP00000019294; ENSOARG00000017973. DR GeneTree; ENSGT00740000114936; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000002356; Chromosome 24. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 313 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004871519. FT DOMAIN 207 292 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 313 AA; 35417 MW; FAFFD0878A488A73 CRC64; VSTMVPVLLS LLLLLGPAAP EETQAGNYSL SFLYTGLSKP REGFPSFQAI AYLNDQPFFH YDSEGRRAKP LAPWSQVEGM EDWEKESALQ RAREDIFMET LSDIMDYYKD REGSHTFQGA FGCELRNNKS SGAFWGYAYD GRDFIKFDKE IPAWVPLDPA AQNTKRKWEA EAVYVQRAKA YLEEECPGTL QRYLPYSRTH LDRRESPSVS VTGHAAPGHK RTLKCLAYDF YPRSIGLHWT RAGDAKEADL GGDVLPSGNG TYQSWVVVEV PSEDQAPYSC HVEHRSLAQP LTVPWDPRQQ ARRKEGSREP SVV // ID W5Q9L1_SHEEP Unreviewed; 230 AA. AC W5Q9L1; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000019403}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000019403, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000019403, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000019403}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000019403} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01059163; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSOART00000019673; ENSOARP00000019403; ENSOARG00000018075. DR GeneTree; ENSGT00760000118960; -. DR OrthoDB; EOG0907079Q; -. DR Proteomes; UP000002356; Chromosome 20. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Immunity {ECO:0000256|SAAS:SAAS00446101}; KW Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00446101}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Transmembrane {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00447790, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 175 197 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 83 167 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 230 AA; 25354 MW; B3878CFE2896C685 CRC64; ACIPGSNSLL LKQIAYDGND YLALNEDLCS WTAVDRAAQI SKLKLEQGGA VGHSRNYLDG DCRGWLHRHL ENGKDTLRRA NPPKTHVTQN PISDHEVSLR CWALGFYPEI SLTWQRDTED QTEDMELVEQ PSGNGSFQEW AALVGPSGEE QRITCNAQHK GLQETLALRW EPPQLAVPNI GIFVSLVLLV VTGAGIWRKK RSGEKAGSYT QAAGKYRGDG SDVFLTVPKG // ID W5QAX9_SHEEP Unreviewed; 336 AA. AC W5QAX9; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 32. DE SubName: Full=Major histocompatibility complex, class I-related {ECO:0000313|Ensembl:ENSOARP00000019874}; GN Name=MR1 {ECO:0000313|Ensembl:ENSOARP00000019874}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000019874, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000019874, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000019874}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000019874} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AMGL01022397; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_004013894.1; XM_004013845.3. DR UniGene; Oar.9028; -. DR Ensembl; ENSOART00000020149; ENSOARP00000019874; ENSOARG00000018509. DR GeneID; 101102078; -. DR KEGG; oas:101102078; -. DR GeneTree; ENSGT00740000114936; -. DR OMA; GYVDSHP; -. DR OrthoDB; EOG091G0K1X; -. DR Proteomes; UP000002356; Chromosome 12. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0002367; P:cytokine production involved in immune response; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl. DR GO; GO:0032620; P:interleukin-17 production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 336 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004870050. FT TRANSMEM 294 318 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 200 279 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 336 AA; 38790 MW; 76AF66A909434F71 CRC64; MMLLLPLIIV LMMKLSDART HSLRYFRLGI SEPGYGIPEF ISAGYVDSHP ITMYNSVSQL KEPRAPWMAE NLEPDHWERY TQLLRGWQQA FKVELKQLQH HYNHSGFNTY QRMIGCELLD DGSTTGFLQY AYDGQDFIIF NKDTLSWIAM DNVANIIRRA WEANRHELQY QKNWLEEECI AWLKRFLEYG KDTLQRTEPP KVRVNYKETF PGITTLYCRA HGFYPPEISI NWMKNGEEVV QDTNYGGILP SGDGTYQTWV SVELDSQNGD IYSCHVEHGG VHMVLPGFQD SETMLLVMKA VGFIVLAIAL AGVGILAWRR KPRGENKVIY LSTPDH // ID X1WGP2_DANRE Unreviewed; 331 AA. AC X1WGP2; DT 14-MAY-2014, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 3. DT 12-SEP-2018, entry version 36. DE SubName: Full=Major histocompatibility complex class I ZAA {ECO:0000313|Ensembl:ENSDARP00000129400}; GN Name=mhc1zaa {ECO:0000313|Ensembl:ENSDARP00000129400, GN ECO:0000313|ZFIN:ZDB-GENE-030916-1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000129400, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000129400, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000129400, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [2] {ECO:0000313|Ensembl:ENSDARP00000129400} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000129400}; RG Ensembl; RL Submitted (MAR-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CU394254; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSDART00000155936; ENSDARP00000129400; ENSDARG00000092162. DR ZFIN; ZDB-GENE-030916-1; mhc1zaa. DR GeneTree; ENSGT00740000114936; -. DR OMA; RDLRSWI; -. DR Proteomes; UP000000437; Chromosome 3. DR Bgee; ENSDARG00000092162; Expressed in 15 organ(s), highest expression level in spleen. DR ExpressionAtlas; X1WGP2; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Proteomics identification {ECO:0000213|PeptideAtlas:X1WGP2}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. SQ SEQUENCE 331 AA; 38764 MW; 0D3A59A482593079 CRC64; MMSGGVASGI CALLCVFLLC GDLPSAQGEK HSLYYIYTSL SKPLDLPGIY EFSAMGLLDD RQIDSYNSEE QRKIPKQQWM KEKMQEDYWE KGTWSRKSKE QWFNVNVHIL MERMRHNMSD LHILQWRHGC EVEIQGSEVK FSKGIDEYGY DGENFLAFDE AESQWVAPVE EALPTKRKWN NIPILNQYTK GYLEKECVDW LNKFREYADE ELRKASSPDV YKLTKKSTKD ETKLKLTCLA TGFYDKDVML NIRRNCLPED ETESTGVRPN HDQTFQLRKS VEIKEDQIDE YDCHLTHRTL KNPVTATRAK QRGIESWNLF FTYGALHIWC C // ID X6R344_HUMAN Unreviewed; 383 AA. AC X6R344; DT 11-JUN-2014, integrated into UniProtKB/TrEMBL. DT 11-JUN-2014, sequence version 1. DT 12-SEP-2018, entry version 42. DE SubName: Full=MHC class I polypeptide-related sequence B {ECO:0000313|Ensembl:ENSP00000252229}; GN Name=MICB {ECO:0000313|Ensembl:ENSP00000252229}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000252229, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000252229, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000252229} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2014) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSP00000407561} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL663061; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR788288; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_005922.2; NM_005931.4. DR UniGene; Hs.731446; -. DR SMR; X6R344; -. DR EPD; X6R344; -. DR MaxQB; X6R344; -. DR PRIDE; X6R344; -. DR Ensembl; ENST00000252229; ENSP00000252229; ENSG00000204516. DR Ensembl; ENST00000451603; ENSP00000407561; ENSG00000231179. DR GeneID; 4277; -. DR KEGG; hsa:4277; -. DR UCSC; uc003ntn.6; human. DR CTD; 4277; -. DR EuPathDB; HostDB:ENSG00000204516.9; -. DR HGNC; HGNC:7091; MICB. DR OpenTargets; ENSG00000204516; -. DR eggNOG; ENOG410J8TZ; Eukaryota. DR eggNOG; ENOG41118IQ; LUCA. DR GeneTree; ENSGT00740000114936; -. DR KO; K07985; -. DR OMA; CVPCCKK; -. DR OrthoDB; EOG091G0ANY; -. DR ChiTaRS; MICB; human. DR GenomeRNAi; 4277; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204516; Expressed in 172 organ(s), highest expression level in blood. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00910515}; KW Proteomics identification {ECO:0000213|MaxQB:X6R344, KW ECO:0000213|PeptideAtlas:X6R344}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00910515}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00910515}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 383 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014595428. FT DOMAIN 207 302 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 383 AA; 42575 MW; 1309E571B48CDF9C CRC64; MGLGRVLLFL AVAFPFAPPA AAAEPHSLRY NLMVLSQDGS VQSGFLAEGH LDGQPFLRYD RQKRRAKPQG QWAENVLGAK TWDTETEDLT ENGQDLRRTL THIKDQKGGL HSLQEIRVCE IHEDSSTRGS RHFYYDGELF LSQNLETQES TVPQSSRAQT LAMNVTNFWK EDAMKTKTHY RAMQADCLQK LQRYLKSGVA IRRTVPPMVN VTCSEVSEGN ITVTCRASSF YPRNITLTWR QDGVSLSHNT QQWGDVLPDG NGTYQTWVAT RIRQGEEQRF TCYMEHSGNH GTHPVPSGKA LVLQSQRTDF PYVSAAMPCF VIIIILCVPC CKKKTSAAEG PELVSLQVLD QHPVGTGDHR DAAQLGFQPL MSATGSTGST EGT // ID ZA2G_BOVIN Reviewed; 299 AA. AC Q3ZCH5; DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 27-SEP-2005, sequence version 1. DT 12-SEP-2018, entry version 106. DE RecName: Full=Zinc-alpha-2-glycoprotein; DE Short=Zn-alpha-2-GP; DE Short=Zn-alpha-2-glycoprotein; DE Flags: Precursor; GN Name=AZGP1; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Hereford; TISSUE=Mammary gland; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Stimulates lipid degradation in adipocytes and causes CC the extensive fat losses associated with some advanced cancers. CC {ECO:0000250}. CC -!- SUBUNIT: Interacts with PIP. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BC102237; AAI02238.1; -; mRNA. DR RefSeq; NP_001029503.1; NM_001034331.1. DR UniGene; Bt.49443; -. DR ProteinModelPortal; Q3ZCH5; -. DR SMR; Q3ZCH5; -. DR STRING; 9913.ENSBTAP00000037042; -. DR PaxDb; Q3ZCH5; -. DR PeptideAtlas; Q3ZCH5; -. DR PRIDE; Q3ZCH5; -. DR Ensembl; ENSBTAT00000037204; ENSBTAP00000037042; ENSBTAG00000026236. DR GeneID; 508800; -. DR KEGG; bta:508800; -. DR CTD; 563; -. DR VGNC; VGNC:26367; AZGP1. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; Q3ZCH5; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Reactome; R-BTA-5223345; Miscellaneous transport and binding events. DR Proteomes; UP000009136; Chromosome 25. DR Bgee; ENSBTAG00000026236; Expressed in 7 organ(s), highest expression level in liver. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Reference proteome; KW Secreted; Signal. FT SIGNAL 1 17 {ECO:0000255}. FT CHAIN 18 299 Zinc-alpha-2-glycoprotein. FT /FTId=PRO_0000317709. FT DOMAIN 204 289 Ig-like C1-type. FT CARBOHYD 24 24 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 125 125 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 256 256 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 120 183 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 222 277 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 299 AA; 33852 MW; 55A2D1179A8FDB54 CRC64; MVPVLLALLL LLGPAVSEET QAGNYSLSFL YTGLSKPREG FPSFQAVAYL NDQPFFHYNS EGRRAEPLAP WSQVEGMEDW EKESALQRAR EDIFMETLSD IMDYYKDREG SHTFQGAFGC ELRNNESSGA FWGYAYDGQD FIKFDKEIPA WVPLDPAAQN TKRKWEAEAV YVQRAKAYLE EECPGMLRRY LPYSRTHLDR QESPSVSVTG HAAPGHKRTL KCLAYDFYPR SIGLHWTRAG DAQEAESGGD VLPSGNGTYQ SWVVVGVPPE DQAPYSCHVE HRSLTRPLTV PWDPRQQAE // ID ZA2G_HUMAN Reviewed; 298 AA. AC P25311; D6W5T8; O60386; Q5XKQ4; Q8N4N0; DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot. DT 23-MAR-2010, sequence version 2. DT 12-SEP-2018, entry version 193. DE RecName: Full=Zinc-alpha-2-glycoprotein; DE Short=Zn-alpha-2-GP; DE Short=Zn-alpha-2-glycoprotein; DE Flags: Precursor; GN Name=AZGP1; Synonyms=ZAG, ZNGP1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Mammary gland; RX PubMed=1915885; DOI=10.1016/0014-5793(91)81271-9; RA Freije J.P., Fueyo A., Uria J., Lopez-Otin C.; RT "Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in RT benign and malignant breast tissues."; RL FEBS Lett. 290:247-249(1991). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=8241150; DOI=10.1021/bi00211a004; RA Ueyama H., Deng H.X., Ohkubo I.; RT "Molecular cloning and chromosomal assignment of the gene for human RT Zn-alpha 2-glycoprotein."; RL Biochemistry 32:12968-12976(1993). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Leukocyte; RX PubMed=8307568; DOI=10.1016/S0888-7543(05)80359-3; RA Freije J.P., Fueyo A., Uria J.A., Velasco G., Sanchez L.M., RA Lopez-Boado Y.S., Lopez-Otin C.; RT "Human Zn-alpha 2-glycoprotein: complete genomic sequence, RT identification of a related pseudogene and relationship to class I RT major histocompatibility complex genes."; RL Genomics 18:575-587(1993). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., RA Waterston R.H., Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12690205; DOI=10.1126/science.1083423; RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., RA Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., RA Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., RA Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., RA Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., RA Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., RA Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., RA Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., RA Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., RA Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., RA Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., RA Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., RA Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., RA Mural R.J., Adams M.D., Tsui L.-C.; RT "Human chromosome 7: DNA sequence and biology."; RL Science 300:767-772(2003). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Colon, and Prostate; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] OF 2-298. RC TISSUE=Liver, and Prostate; RX PubMed=2049092; DOI=10.1016/0006-291X(91)91844-3; RA Ueyama H., Niwa M., Tada T., Sasaki M., Ohkubo I.; RT "Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein RT cDNA and chromosomal assignment of its gene."; RL Biochem. Biophys. Res. Commun. 177:696-703(1991). RN [9] RP PROTEIN SEQUENCE OF 21-298, AND PYROGLUTAMATE FORMATION AT GLN-21. RC TISSUE=Plasma; RX PubMed=3422450; DOI=10.1073/pnas.85.3.679; RA Araki T., Gejyo F., Takagaki K., Haupt H., Schwick H.G., Buergi W., RA Marti T., Schaller J., Rickli E., Brossmer R., Atkinson P.H., RA Putnam F.W., Schmid K.; RT "Complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein RT and its homology to histocompatibility antigens."; RL Proc. Natl. Acad. Sci. U.S.A. 85:679-683(1988). RN [10] RP PROTEIN SEQUENCE OF 21-35. RX PubMed=15340161; DOI=10.1110/ps.04682504; RA Zhang Z., Henzel W.J.; RT "Signal peptide prediction based on analysis of experimentally RT verified cleavage sites."; RL Protein Sci. 13:2819-2824(2004). RN [11] RP CHARACTERIZATION, AND CRYSTALLIZATION. RX PubMed=9114041; DOI=10.1073/pnas.94.9.4626; RA Sanchez L.M., Lopez-Otin C., Bjorkman P.J.; RT "Biochemical characterization and crystallization of human Zn-alpha2- RT glycoprotein, a soluble class I major histocompatibility complex RT homolog."; RL Proc. Natl. Acad. Sci. U.S.A. 94:4626-4630(1997). RN [12] RP IN VITRO BINDING OF FATTY ACID. RX PubMed=11425849; DOI=10.1074/jbc.C100301200; RA Kennedy M.W., Heikema A.P., Cooper A., Bjorkman P.J., Sanchez L.M.; RT "Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat- RT depleting factor related to major histocompatibility complex RT proteins."; RL J. Biol. Chem. 276:35008-35013(2001). RN [13] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-128. RC TISSUE=Bile; RX PubMed=15084671; DOI=10.1074/mcp.M400015-MCP200; RA Kristiansen T.Z., Bunkenborg J., Gronborg M., Molina H., RA Thuluvath P.J., Argani P., Goggins M.G., Maitra A., Pandey A.; RT "A proteomic analysis of human bile."; RL Mol. Cell. Proteomics 3:715-728(2004). RN [14] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112 AND ASN-128. RC TISSUE=Plasma; RX PubMed=14760718; DOI=10.1002/pmic.200300556; RA Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.; RT "Screening for N-glycosylated proteins by liquid chromatography mass RT spectrometry."; RL Proteomics 4:454-465(2004). RN [15] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112. RC TISSUE=Plasma; RX PubMed=16335952; DOI=10.1021/pr0502065; RA Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., RA Moore R.J., Smith R.D.; RT "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, RT hydrazide chemistry, and mass spectrometry."; RL J. Proteome Res. 4:2070-2080(2005). RN [16] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-109; ASN-112 AND ASN-128. RC TISSUE=Saliva; RX PubMed=16740002; DOI=10.1021/pr050492k; RA Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., RA Loo J.A.; RT "Identification of N-linked glycoproteins in human saliva by RT glycoprotein capture and mass spectrometry."; RL J. Proteome Res. 5:1493-1503(2006). RN [17] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-109; ASN-112 AND ASN-128. RC TISSUE=Milk; RX PubMed=18780401; DOI=10.1002/pmic.200701057; RA Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.; RT "Identification of N-linked glycoproteins in human milk by hydrophilic RT interaction liquid chromatography and mass spectrometry."; RL Proteomics 8:3833-3847(2008). RN [18] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-109; ASN-112 AND ASN-128. RC TISSUE=Liver; RX PubMed=19159218; DOI=10.1021/pr8008012; RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; RT "Glycoproteomics analysis of human liver tissue by combination of RT multiple enzyme digestion and hydrazide chemistry."; RL J. Proteome Res. 8:651-661(2009). RN [19] RP GLYCOSYLATION AT ASN-109 AND ASN-128. RX PubMed=19139490; DOI=10.1074/mcp.M800504-MCP200; RA Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., RA Zheng Z.B., Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., RA Zhang Y.K., Deng Y.L., Ying W.T., He S.M., Qian X.H.; RT "A strategy for precise and large scale identification of core RT fucosylated glycoproteins."; RL Mol. Cell. Proteomics 8:913-923(2009). RN [20] RP GLYCOSYLATION AT ASN-128, STRUCTURE OF CARBOHYDRATES, AND RP IDENTIFICATION BY MASS SPECTROMETRY. RX PubMed=22171320; DOI=10.1074/mcp.M111.013649; RA Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.; RT "Human urinary glycoproteomics; attachment site specific analysis of RT N-and O-linked glycosylations by CID and ECD."; RL Mol. Cell. Proteomics 11:1-17(2012). RN [21] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [22] RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS), DISULFIDE BONDS, AND RP GLYCOSYLATION AT ASN-109; ASN-128 AND ASN-259. RX PubMed=10206894; DOI=10.1126/science.283.5409.1914; RA Sanchez L.M., Chirino A.J., Bjorkman P.J.; RT "Crystal structure of human ZAG, a fat-depleting factor related to MHC RT molecules."; RL Science 283:1914-1919(1999). RN [23] RP X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 21-298, DISULFIDE BONDS, AND RP GLYCOSYLATION AT ASN-128 AND ASN-259. RX PubMed=15477100; DOI=10.1016/j.jsb.2004.04.009; RA Delker S.L., West A.P. Jr., McDermott L., Kennedy M.W., Bjorkman P.J.; RT "Crystallographic studies of ligand binding by Zn-alpha2- RT glycoprotein."; RL J. Struct. Biol. 148:205-213(2004). RN [24] RP X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 32-149 IN COMPLEX WITH PIP, RP DISULFIDE BONDS, AND GLYCOSYLATION AT ASN-259. RX PubMed=18930737; DOI=10.1016/j.jmb.2008.09.072; RA Hassan M.I., Bilgrami S., Kumar V., Singh N., Yadav S., Kaur P., RA Singh T.P.; RT "Crystal structure of the novel complex formed between zinc alpha2- RT glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human RT seminal plasma."; RL J. Mol. Biol. 384:663-672(2008). CC -!- FUNCTION: Stimulates lipid degradation in adipocytes and causes CC the extensive fat losses associated with some advanced cancers. CC May bind polyunsaturated fatty acids. CC -!- SUBUNIT: Interacts with PIP. {ECO:0000269|PubMed:18930737}. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Blood plasma, seminal plasma, urine, saliva, CC sweat, epithelial cells of various human glands, liver. CC -!- PTM: N-glycosylated. N-glycan at Asn-128: Hex5HexNAc4. CC {ECO:0000269|PubMed:10206894, ECO:0000269|PubMed:14760718, CC ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:15477100, CC ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, CC ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:18930737, CC ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, CC ECO:0000269|PubMed:22171320}. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC -!- CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator. CC {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAA61311.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; CC Sequence=BAA03123.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; CC Sequence=BAA14417.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; CC Sequence=CAA42438.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X59766; CAA42438.1; ALT_INIT; mRNA. DR EMBL; D14034; BAA03123.1; ALT_INIT; Genomic_DNA. DR EMBL; X69953; CAA49574.1; -; Genomic_DNA. DR EMBL; AC004522; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH236956; EAL23862.1; -; Genomic_DNA. DR EMBL; CH471091; EAW76621.1; -; Genomic_DNA. DR EMBL; CH471091; EAW76622.1; -; Genomic_DNA. DR EMBL; BC005306; AAH05306.1; -; mRNA. DR EMBL; BC033830; AAH33830.1; -; mRNA. DR EMBL; D90427; BAA14417.1; ALT_INIT; mRNA. DR EMBL; M76707; AAA61311.1; ALT_INIT; mRNA. DR CCDS; CCDS5680.1; -. DR PIR; A54175; A54175. DR RefSeq; NP_001176.1; NM_001185.3. DR UniGene; Hs.546239; -. DR PDB; 1T7V; X-ray; 1.95 A; A=21-298. DR PDB; 1T7W; X-ray; 2.70 A; A=21-298. DR PDB; 1T7X; X-ray; 3.10 A; A=21-298. DR PDB; 1T7Y; X-ray; 2.80 A; A=21-298. DR PDB; 1T7Z; X-ray; 3.00 A; A=21-298. DR PDB; 1T80; X-ray; 2.10 A; A=21-298. DR PDB; 1ZAG; X-ray; 2.80 A; A/B/C/D=25-298. DR PDB; 3ES6; X-ray; 3.23 A; A=21-298. DR PDBsum; 1T7V; -. DR PDBsum; 1T7W; -. DR PDBsum; 1T7X; -. DR PDBsum; 1T7Y; -. DR PDBsum; 1T7Z; -. DR PDBsum; 1T80; -. DR PDBsum; 1ZAG; -. DR PDBsum; 3ES6; -. DR ProteinModelPortal; P25311; -. DR SMR; P25311; -. DR BioGrid; 107040; 27. DR CORUM; P25311; -. DR IntAct; P25311; 16. DR MINT; P25311; -. DR STRING; 9606.ENSP00000292401; -. DR DrugBank; DB03721; N-acetyl-alpha-neuraminic acid. DR CarbonylDB; P25311; -. DR GlyConnect; 692; -. DR iPTMnet; P25311; -. DR PhosphoSitePlus; P25311; -. DR UniCarbKB; P25311; -. DR BioMuta; AZGP1; -. DR DMDM; 292495049; -. DR REPRODUCTION-2DPAGE; IPI00166729; -. DR SWISS-2DPAGE; P25311; -. DR EPD; P25311; -. DR MaxQB; P25311; -. DR PaxDb; P25311; -. DR PeptideAtlas; P25311; -. DR PRIDE; P25311; -. DR ProteomicsDB; 54267; -. DR Ensembl; ENST00000292401; ENSP00000292401; ENSG00000160862. DR GeneID; 563; -. DR KEGG; hsa:563; -. DR UCSC; uc003ush.4; human. DR CTD; 563; -. DR DisGeNET; 563; -. DR EuPathDB; HostDB:ENSG00000160862.12; -. DR GeneCards; AZGP1; -. DR HGNC; HGNC:910; AZGP1. DR HPA; CAB016087; -. DR HPA; CAB032276; -. DR HPA; HPA012582; -. DR MIM; 194460; gene. DR neXtProt; NX_P25311; -. DR OpenTargets; ENSG00000160862; -. DR PharmGKB; PA25203; -. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; P25311; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR PhylomeDB; P25311; -. DR TreeFam; TF336617; -. DR Reactome; R-HSA-5223345; Miscellaneous transport and binding events. DR ChiTaRS; AZGP1; human. DR EvolutionaryTrace; P25311; -. DR GeneWiki; AZGP1; -. DR GenomeRNAi; 563; -. DR PRO; PR:P25311; -. DR Proteomes; UP000005640; Chromosome 7. DR Bgee; ENSG00000160862; Expressed in 195 organ(s), highest expression level in minor salivary gland. DR CleanEx; HS_AZGP1; -. DR ExpressionAtlas; P25311; baseline and differential. DR Genevisible; P25311; HS. DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005576; C:extracellular region; HDA:BHF-UCL. DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB. DR GO; GO:0005634; C:nucleus; HDA:UniProtKB. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0008320; F:protein transmembrane transporter activity; NAS:UniProtKB. DR GO; GO:0004540; F:ribonuclease activity; NAS:UniProtKB. DR GO; GO:0007155; P:cell adhesion; IDA:UniProtKB. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:UniProtKB. DR GO; GO:0008285; P:negative regulation of cell proliferation; NAS:UniProtKB. DR GO; GO:0001895; P:retina homeostasis; HEP:UniProtKB. DR GO; GO:0055085; P:transmembrane transport; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Direct protein sequencing; KW Disulfide bond; Glycoprotein; Pyrrolidone carboxylic acid; KW Reference proteome; Secreted; Signal. FT SIGNAL 1 20 {ECO:0000269|PubMed:15340161, FT ECO:0000269|PubMed:3422450}. FT CHAIN 21 298 Zinc-alpha-2-glycoprotein. FT /FTId=PRO_0000019012. FT DOMAIN 207 292 Ig-like C1-type. FT MOD_RES 21 21 Pyrrolidone carboxylic acid. FT {ECO:0000269|PubMed:3422450}. FT CARBOHYD 109 109 N-linked (GlcNAc...) (complex) FT asparagine. {ECO:0000269|PubMed:10206894, FT ECO:0000269|PubMed:16740002, FT ECO:0000269|PubMed:18780401, FT ECO:0000269|PubMed:19139490, FT ECO:0000269|PubMed:19159218}. FT CARBOHYD 112 112 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:14760718, FT ECO:0000269|PubMed:16335952, FT ECO:0000269|PubMed:16740002, FT ECO:0000269|PubMed:18780401, FT ECO:0000269|PubMed:19159218}. FT CARBOHYD 128 128 N-linked (GlcNAc...) (complex) FT asparagine. {ECO:0000269|PubMed:10206894, FT ECO:0000269|PubMed:14760718, FT ECO:0000269|PubMed:15084671, FT ECO:0000269|PubMed:15477100, FT ECO:0000269|PubMed:16740002, FT ECO:0000269|PubMed:18780401, FT ECO:0000269|PubMed:19139490, FT ECO:0000269|PubMed:19159218, FT ECO:0000269|PubMed:22171320}. FT CARBOHYD 259 259 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:10206894, FT ECO:0000269|PubMed:15477100, FT ECO:0000269|PubMed:18930737}. FT DISULFID 123 186 FT DISULFID 225 280 FT CONFLICT 2 2 V -> S (in Ref. 1; CAA42438). FT {ECO:0000305}. FT CONFLICT 5 5 V -> L (in Ref. 1; CAA42438). FT {ECO:0000305}. FT CONFLICT 33 33 I -> V (in Ref. 7; AAH05306). FT {ECO:0000305}. FT CONFLICT 85 85 Q -> E (in Ref. 9; AA sequence). FT {ECO:0000305}. FT CONFLICT 96 97 Missing (in Ref. 9; AA sequence). FT {ECO:0000305}. FT CONFLICT 244 244 E -> Q (in Ref. 9; AA sequence). FT {ECO:0000305}. FT STRAND 27 39 {ECO:0000244|PDB:1T7V}. FT STRAND 42 44 {ECO:0000244|PDB:1ZAG}. FT STRAND 46 53 {ECO:0000244|PDB:1T7V}. FT STRAND 56 62 {ECO:0000244|PDB:1T7V}. FT TURN 63 65 {ECO:0000244|PDB:1T7V}. FT HELIX 72 76 {ECO:0000244|PDB:1T7V}. FT STRAND 79 81 {ECO:0000244|PDB:3ES6}. FT HELIX 83 107 {ECO:0000244|PDB:1T7V}. FT STRAND 116 126 {ECO:0000244|PDB:1T7V}. FT STRAND 129 139 {ECO:0000244|PDB:1T7V}. FT STRAND 142 148 {ECO:0000244|PDB:1T7V}. FT TURN 149 152 {ECO:0000244|PDB:1T7V}. FT STRAND 153 156 {ECO:0000244|PDB:1T7V}. FT HELIX 159 168 {ECO:0000244|PDB:1T7V}. FT HELIX 173 183 {ECO:0000244|PDB:1T7V}. FT HELIX 185 196 {ECO:0000244|PDB:1T7V}. FT HELIX 198 201 {ECO:0000244|PDB:1T7V}. FT STRAND 208 215 {ECO:0000244|PDB:1T7V}. FT STRAND 217 219 {ECO:0000244|PDB:1T7X}. FT STRAND 221 233 {ECO:0000244|PDB:1T7V}. FT STRAND 235 241 {ECO:0000244|PDB:1T7V}. FT STRAND 244 246 {ECO:0000244|PDB:1ZAG}. FT STRAND 249 256 {ECO:0000244|PDB:1T7V}. FT TURN 257 260 {ECO:0000244|PDB:1T7V}. FT STRAND 261 270 {ECO:0000244|PDB:1T7V}. FT STRAND 278 284 {ECO:0000244|PDB:1T7V}. FT STRAND 291 294 {ECO:0000244|PDB:1T7V}. SQ SEQUENCE 298 AA; 34259 MW; 006A153A8E32A0B1 CRC64; MVRMVPVLLS LLLLLGPAVP QENQDGRYSL TYIYTGLSKH VEDVPAFQAL GSLNDLQFFR YNSKDRKSQP MGLWRQVEGM EDWKQDSQLQ KAREDIFMET LKDIVEYYND SNGSHVLQGR FGCEIENNRS SGAFWKYYYD GKDYIEFNKE IPAWVPFDPA AQITKQKWEA EPVYVQRAKA YLEEECPATL RKYLKYSKNI LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT RAGEVQEPEL RGDVLHNGNG TYQSWVVVAV PPQDTAPYSC HVQHSSLAQP LVVPWEAS // ID ZA2G_MOUSE Reviewed; 307 AA. AC Q64726; Q9DBB7; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 27-JUL-2011, sequence version 2. DT 12-SEP-2018, entry version 149. DE RecName: Full=Zinc-alpha-2-glycoprotein; DE Short=Zn-alpha-2-GP; DE Short=Zn-alpha-2-glycoprotein; DE Flags: Precursor; GN Name=Azgp1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=BALB/cJ; TISSUE=Liver; RX PubMed=7852290; RA Ueyama H., Naitoh H., Ohkubo I.; RT "Structure and expression of rat and mouse mRNAs for Zn-alpha 2- RT glycoprotein."; RL J. Biochem. 116:677-681(1994). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/SvJ; RA Wanner V., Bahram S.; RT "The mouse ZAG gene."; RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=KK/Ta; TISSUE=Kidney; RA Gohda T.; RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Liver; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; TISSUE=Liver; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 235-304. RC STRAIN=C57BL/6J; RX PubMed=7797272; DOI=10.1007/BF00164991; RA Noguchi M., Kitabatake A., Ishibashi T., Kasahara M.; RT "The MHC class I-like Zn-alpha 2-glycoprotein gene maps to mouse RT chromosome 5."; RL Immunogenetics 42:72-74(1995). RN [7] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-190. RC STRAIN=C57BL/6J; TISSUE=Plasma; RX PubMed=17330941; DOI=10.1021/pr0604559; RA Bernhard O.K., Kapp E.A., Simpson R.J.; RT "Enhanced analysis of the mouse plasma proteome using cysteine- RT containing tryptic glycopeptides."; RL J. Proteome Res. 6:987-995(2007). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brown adipose tissue, Heart, Liver, Lung, Spleen, and Testis; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Stimulates lipid degradation in adipocytes and causes CC the extensive fat losses associated with some advanced cancers. CC {ECO:0000250}. CC -!- SUBUNIT: Interacts with PIP. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; D21059; BAA04638.1; -; mRNA. DR EMBL; AF281658; AAQ14325.1; -; Genomic_DNA. DR EMBL; AY248694; AAO93093.1; -; mRNA. DR EMBL; AK005051; BAB23777.1; -; mRNA. DR EMBL; BC061646; AAH61646.1; -; mRNA. DR EMBL; D44593; BAA07996.1; -; Genomic_DNA. DR CCDS; CCDS19783.1; -. DR PIR; JX0352; JX0352. DR RefSeq; NP_038506.2; NM_013478.2. DR UniGene; Mm.30061; -. DR ProteinModelPortal; Q64726; -. DR SMR; Q64726; -. DR STRING; 10090.ENSMUSP00000038559; -. DR iPTMnet; Q64726; -. DR PhosphoSitePlus; Q64726; -. DR MaxQB; Q64726; -. DR PaxDb; Q64726; -. DR PeptideAtlas; Q64726; -. DR PRIDE; Q64726; -. DR Ensembl; ENSMUST00000035390; ENSMUSP00000038559; ENSMUSG00000037053. DR GeneID; 12007; -. DR KEGG; mmu:12007; -. DR UCSC; uc009aeh.2; mouse. DR CTD; 563; -. DR MGI; MGI:103163; Azgp1. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR GeneTree; ENSGT00740000114936; -. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; Q64726; -. DR OMA; TYQSWVV; -. DR OrthoDB; EOG091G0K1X; -. DR TreeFam; TF336617; -. DR Reactome; R-MMU-5223345; Miscellaneous transport and binding events. DR ChiTaRS; Azgp1; mouse. DR PRO; PR:Q64726; -. DR Proteomes; UP000000589; Chromosome 5. DR Bgee; ENSMUSG00000037053; Expressed in 129 organ(s), highest expression level in left lobe of liver. DR CleanEx; MM_AZGP1; -. DR ExpressionAtlas; Q64726; baseline and differential. DR Genevisible; Q64726; MM. DR GO; GO:0005615; C:extracellular space; ISO:MGI. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0007155; P:cell adhesion; ISS:UniProtKB. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI. DR GO; GO:0040014; P:regulation of multicellular organism growth; NAS:UniProtKB. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal. FT SIGNAL 1 17 {ECO:0000250}. FT CHAIN 18 307 Zinc-alpha-2-glycoprotein. FT /FTId=PRO_0000019013. FT DOMAIN 202 287 Ig-like C1-type. FT MOD_RES 18 18 Pyrrolidone carboxylic acid. FT {ECO:0000250|UniProtKB:P25311}. FT CARBOHYD 123 123 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 190 190 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:17330941}. FT CARBOHYD 254 254 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 118 181 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 220 275 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT CONFLICT 24 24 Y -> S (in Ref. 1; BAB23777 and 5; FT AAH61646). {ECO:0000305}. SQ SEQUENCE 307 AA; 35332 MW; A116304EFE10F814 CRC64; MVPVLLSLPL LLGPAVFQET GSYYLTFLYT GLSRPSKGFP RFQATAFLND QAFFHYNSNS GKAEPVGPWS QVEGMEDWEK ESQLQRAREE IFLVTLKDIM DYYKDTTGSH TFQGMFGCEI TNNRSSGAVW RYAYDGEDFI EFNKEIPAWI PLDPAAANTK LKWEAEKVYV QRAKAYLEEE CPEMLKRYLN YSRSHLDRID PPTVTITSRV IPGGNRIFKC LAYGFYPQRI SLHWNKANKK LAFEPERGVF PNGNGTYLSW AEVEVSPQDI DPFFCLIDHR GFSQSLSVQW DRTRKVKDEN NVVAQPQ // ID ZA2G_RAT Reviewed; 296 AA. AC Q63678; Q63523; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 23-MAY-2018, entry version 124. DE RecName: Full=Zinc-alpha-2-glycoprotein; DE Short=Zn-alpha-2-GP; DE Short=Zn-alpha-2-glycoprotein; DE Flags: Precursor; GN Name=Azgp1; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Sprague-Dawley; TISSUE=Liver; RX PubMed=7852290; RA Ueyama H., Naitoh H., Ohkubo I.; RT "Structure and expression of rat and mouse mRNAs for Zn-alpha 2- RT glycoprotein."; RL J. Biochem. 116:677-681(1994). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 4-296. RC TISSUE=Liver; RX PubMed=8056339; DOI=10.1016/0378-1119(94)90014-0; RA Fueyo A., Uria J.A., Freije J.M.P., Lopez-Otin C.; RT "Cloning and expression analysis of the cDNA encoding rat Zn-alpha 2- RT glycoprotein."; RL Gene 145:245-249(1994). CC -!- FUNCTION: Stimulates lipid degradation in adipocytes and causes CC the extensive fat losses associated with some advanced cancers. CC {ECO:0000250}. CC -!- SUBUNIT: Interacts with PIP. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Expressed in liver, but not in a wide number CC of tissues, including prostate, mammary gland, kidney, intestine, CC lung, pancreas, ovary, uterus, thyroid, placenta, spleen, brain CC and heart. CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; D21058; BAA04637.1; -; mRNA. DR EMBL; X75309; CAA53057.1; -; mRNA. DR PIR; JX0353; JX0353. DR UniGene; Rn.5007; -. DR ProteinModelPortal; Q63678; -. DR SMR; Q63678; -. DR STRING; 10116.ENSRNOP00000001801; -. DR PhosphoSitePlus; Q63678; -. DR PaxDb; Q63678; -. DR PRIDE; Q63678; -. DR UCSC; RGD:2187; rat. DR RGD; 2187; Azgp1. DR eggNOG; ENOG410J9FR; Eukaryota. DR eggNOG; ENOG4111CJX; LUCA. DR HOGENOM; HOG000296917; -. DR HOVERGEN; HBG016709; -. DR InParanoid; Q63678; -. DR PhylomeDB; Q63678; -. DR PRO; PR:Q63678; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005615; C:extracellular space; TAS:RGD. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0007155; P:cell adhesion; ISS:UniProtKB. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal. FT SIGNAL 1 17 {ECO:0000250}. FT CHAIN 18 296 Zinc-alpha-2-glycoprotein. FT /FTId=PRO_0000019014. FT DOMAIN 202 287 Ig-like C1-type. FT MOD_RES 18 18 Pyrrolidone carboxylic acid. FT {ECO:0000250|UniProtKB:P25311}. FT CARBOHYD 123 123 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 254 254 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 118 181 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 220 275 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT CONFLICT 120 120 I -> S (in Ref. 2; CAA53057). FT {ECO:0000305}. FT CONFLICT 194 194 S -> C (in Ref. 2; CAA53057). FT {ECO:0000305}. SQ SEQUENCE 296 AA; 34017 MW; 1259467DD18D4E3A CRC64; MVPVLLSLPL LLGPAVLQET GSYSLIFLYT GLSRPSKGLP RFQATAFLND QAFFHYNSNS GKAEPVEPWS HVEGMEDWEK ESQLQRAREE IFLVTLKDIM DYYEDSTGSH TFQGMFGCEI TNNRSSGAVW RYAYDGEDFI EFNKEIPAWI PLDPAAANTK LKWEAEKVYV QRAKAYLEEE CPTMLKKYLT YSRSHLDRTD PPTVKITSRV APGRNRIFRC LAYDFYPQRI SLHWNQASKK LASEPERGVF PNGNGTYLSW MEVEVPPQNR DPFVCHIEHK GLSQSLSVQW DEKSKV //