RID: 7XH5X1MK013 Job Title:CAA42196:activator of (R)-hydroxyglutaryl-CoA... Program: BLASTP Query: activator of (R)-hydroxyglutaryl-CoA dehydratase [Acidaminococcus fermentans DSM 20731] ID: CAA42196.1(amino acid) Length: 260 Database: swissprot Non-redundant UniProtKB/SwissProt sequences Sequences producing significant alignments: Scientific Common Max Total Query E Per. Acc. Description Name Name Taxid Score Score cover Value Ident Len Accession RecName: Full=(R)-2-hydroxyglutaryl-CoA dehydratase activating... Acidaminococ... NA 591001 486 486 92% 1e-175 100.00 260 P11568.2 RecName: Full=Activator of lactoyl-CoA dehydratase; AltName:... Anaerotignum... NA 28446 268 268 91% 1e-89 57.32 259 G3KIM5.1 RecName: Full=(R)-phenyllactate dehydratase activator; AltName... Clostridium ... NA 1509 265 265 91% 3e-88 57.14 264 Q93AM0.1 RecName: Full=2-hydroxyisocaproyl-CoA dehydratase activator... Clostridioid... NA 1496 253 253 90% 3e-83 54.47 266 Q5U925.1 RecName: Full=Uncharacterized protein YjiL [Escherichia coli... Escherichia ... NA 83333 167 167 91% 9e-50 42.86 255 P39383.2 RecName: Full=Benzoyl-CoA reductase subunit A; AltName:... Thauera arom... NA 59405 148 148 69% 9e-41 41.71 438 O87876.1 RecName: Full=Uncharacterized protein MJ0004 [Methanocaldococc... Methanocaldo... NA 243232 138 138 87% 9e-39 38.43 243 Q60315.1 RecName: Full=Benzoyl-CoA reductase subunit D; AltName:... Thauera arom... NA 59405 100 100 87% 6e-24 30.38 282 O87877.1 RecName: Full=Uncharacterized protein MJ0800 [Methanocaldococc... Methanocaldo... NA 243232 88.2 88.2 89% 8e-19 29.71 415 Q58210.1 Alignments: >RecName: Full=(R)-2-hydroxyglutaryl-CoA dehydratase activating ATPase; AltName: Full=(R)-2-hydroxyglutaryl-CoA dehydratase activase; AltName: Full=(R)-2-hydroxyglutaryl-CoA dehydratase, component A; AltName: Full=ATP-coupled electron transfer protein HgdC; AltName: Full=Activator of (R)-2-hydroxyglutaryl-CoA dehydratase [Acidaminococcus fermentans DSM 20731] Sequence ID: P11568.2 Length: 260 Range 1: 1 to 240 Score:486 bits(1252), Expect:1e-175, Method:Compositional matrix adjust., Identities:240/240(100%), Positives:240/240(100%), Gaps:0/240(0%) Query 1 MSIYTLGIDVGSTASKCIILKDGKEIVAKSLVAVGTGTSGPARSISEVLENAHMKKEDMA 60 MSIYTLGIDVGSTASKCIILKDGKEIVAKSLVAVGTGTSGPARSISEVLENAHMKKEDMA Sbjct 1 MSIYTLGIDVGSTASKCIILKDGKEIVAKSLVAVGTGTSGPARSISEVLENAHMKKEDMA 60 Query 61 FTLATGYGRNSLEGIADKQMSELSCHAMGASFIWPNVHTVIDIGGQDVKVIHVENGTMTN 120 FTLATGYGRNSLEGIADKQMSELSCHAMGASFIWPNVHTVIDIGGQDVKVIHVENGTMTN Sbjct 61 FTLATGYGRNSLEGIADKQMSELSCHAMGASFIWPNVHTVIDIGGQDVKVIHVENGTMTN 120 Query 121 FQMNDKCAAGTGRFLDVMANILEVKVSDLAELGAKSTKRVAISSTCTVFAESEVISQLSK 180 FQMNDKCAAGTGRFLDVMANILEVKVSDLAELGAKSTKRVAISSTCTVFAESEVISQLSK Sbjct 121 FQMNDKCAAGTGRFLDVMANILEVKVSDLAELGAKSTKRVAISSTCTVFAESEVISQLSK 180 Query 181 GTDKIDIIAGIHRSVASRVIGLANRVGIVKDVVMTGGVAQNYGVRGALEEGLGVEIKTSP 240 GTDKIDIIAGIHRSVASRVIGLANRVGIVKDVVMTGGVAQNYGVRGALEEGLGVEIKTSP Sbjct 181 GTDKIDIIAGIHRSVASRVIGLANRVGIVKDVVMTGGVAQNYGVRGALEEGLGVEIKTSP 240 >RecName: Full=Activator of lactoyl-CoA dehydratase; AltName: Full=Lactoyl-CoA dehydratase component E I [Anaerotignum propionicum] Sequence ID: G3KIM5.1 Length: 259 Range 1: 1 to 238 Score:268 bits(686), Expect:1e-89, Method:Compositional matrix adjust., Identities:137/239(57%), Positives:177/239(74%), Gaps:2/239(0%) Query 3 IYTLGIDVGSTASKCIILKDGKEIVAKSLVAVGTGTSGPARSISEVLENAHMKKEDMAFT 62 +YTLGIDVGS +SK +ILKDGK+IVA +V VGTG+SGP R++ + E + +KKED+++T Sbjct 1 MYTLGIDVGSASSKAVILKDGKDIVAAEVVQVGTGSSGPQRALDKAFEVSGLKKEDISYT 60 Query 63 LATGYGRNSLEGIADKQMSELSCHAMGASFIWPNVHTVIDIGGQDVKVIHVEN-GTMTNF 121 +ATGYGR + ADKQ+SE+SCHA G F+ P T+IDIGGQD K I +++ G + F Sbjct 61 VATGYGRFNFSD-ADKQISEISCHAKGIYFLVPTARTIIDIGGQDAKAIRLDDKGGIKQF 119 Query 122 QMNDKCAAGTGRFLDVMANILEVKVSDLAELGAKSTKRVAISSTCTVFAESEVISQLSKG 181 MNDKCAAGTGRFL+VMA +LE + ++AEL ++T ISSTCTVFAESEVISQLS G Sbjct 120 FMNDKCAAGTGRFLEVMARVLETTLDEMAELDEQATDTAPISSTCTVFAESEVISQLSNG 179 Query 182 TDKIDIIAGIHRSVASRVIGLANRVGIVKDVVMTGGVAQNYGVRGALEEGLGVEIKTSP 240 + +II G+H SVASR GLA R G+ KDVVMTGGVA+N GV A+ L ++ +P Sbjct 180 VSRNNIIKGVHLSVASRACGLAYRGGLEKDVVMTGGVAKNAGVVRAVAGVLKTDVIVAP 238 >RecName: Full=(R)-phenyllactate dehydratase activator; AltName: Full=Initiator of phenyllactate dehydratase [Clostridium sporogenes] Sequence ID: Q93AM0.1 Length: 264 Range 1: 4 to 240 Score:265 bits(677), Expect:3e-88, Method:Compositional matrix adjust., Identities:136/238(57%), Positives:180/238(75%), Gaps:2/238(0%) Query 3 IYTLGIDVGSTASKCIILKDGKEIVAKSLVAVGTGTSGPARSISEVLENAHMKKEDMAFT 62 IYT+G+D+GSTASK ++LK+GKEIV++++++VG GTSGP R+I VL++A + ED+ + Sbjct 4 IYTMGVDIGSTASKTVVLKNGKEIVSQAVISVGAGTSGPKRAIDSVLKDAKLSIEDLDYI 63 Query 63 LATGYGRNSLEGIADKQMSELSCHAMGASFIWPNVHTVIDIGGQDVKVIHV-ENGTMTNF 121 ++TGYGRNS + A+KQ+SELSCHA G F TVIDIGGQD+KV+ + ++G + NF Sbjct 64 VSTGYGRNSFD-FANKQISELSCHAKGVYFDNNKARTVIDIGGQDIKVLKLADSGRLLNF 122 Query 122 QMNDKCAAGTGRFLDVMANILEVKVSDLAELGAKSTKRVAISSTCTVFAESEVISQLSKG 181 MNDKCAAGTGRFLDVM+ ++EV V +L + +S ISSTCTVFAESEVISQL++G Sbjct 123 IMNDKCAAGTGRFLDVMSRVIEVPVDELGKKALESKNPCTISSTCTVFAESEVISQLARG 182 Query 182 TDKIDIIAGIHRSVASRVIGLANRVGIVKDVVMTGGVAQNYGVRGALEEGLGVEIKTS 239 D+IAGI +SVASRV LA R GI + VVM+GGVA+N GV A+E LG +I S Sbjct 183 VKTEDLIAGICKSVASRVASLAKRSGIEELVVMSGGVAKNIGVVKAMEAELGRDIYIS 240 >RecName: Full=2-hydroxyisocaproyl-CoA dehydratase activator [Clostridioides difficile] Sequence ID: Q5U925.1 Length: 266 Range 1: 1 to 234 Score:253 bits(645), Expect:3e-83, Method:Compositional matrix adjust., Identities:128/235(54%), Positives:169/235(71%), Gaps:2/235(0%) Query 3 IYTLGIDVGSTASKCIILKDGKEIVAKSLVAVGTGTSGPARSISEVLENAHMKKEDMAFT 62 +YT+G+D+GSTASK +ILK+G++IVA ++ GTGT+GP+R + ++ + +ED+ Sbjct 1 MYTMGLDIGSTASKGVILKNGEDIVASETISSGTGTTGPSRVLEKLYGKTGLAREDIKKV 60 Query 63 LATGYGRNSLEGIADKQMSELSCHAMGASFIWPNVHTVIDIGGQDVKVIHVEN-GTMTNF 121 + TGYGR + ADKQ+SELSCHA G +FI P T+IDIGGQD KV+ ++N G + NF Sbjct 61 VVTGYGRMNYSD-ADKQISELSCHARGVNFIIPETRTIIDIGGQDAKVLKLDNNGRLLNF 119 Query 122 QMNDKCAAGTGRFLDVMANILEVKVSDLAELGAKSTKRVAISSTCTVFAESEVISQLSKG 181 MNDKCAAGTGRFLDVMA I+EV VS+L + S V+ISSTCTVFAESEVIS LS+ Sbjct 120 LMNDKCAAGTGRFLDVMAKIIEVDVSELGSISMNSQNEVSISSTCTVFAESEVISHLSEN 179 Query 182 TDKIDIIAGIHRSVASRVIGLANRVGIVKDVVMTGGVAQNYGVRGALEEGLGVEI 236 DI+AGIH SVA RV L R+G+ ++VVM GGVA+N G+ A+ + EI Sbjct 180 AKIEDIVAGIHTSVAKRVSSLVKRIGVQRNVVMVGGVARNSGIVRAMAREINTEI 234 >RecName: Full=Uncharacterized protein YjiL [Escherichia coli K-12] Sequence ID: P39383.2 Length: 255 Range 1: 3 to 234 Score:167 bits(422), Expect:9e-50, Method:Compositional matrix adjust., Identities:102/238(43%), Positives:134/238(56%), Gaps:7/238(2%) Query 4 YTLGIDVGSTASKCIILKDGKEIVAKSLVAVGTGTSGPARSISEVLENAHMKKEDMAFTL 63 Y++GID GSTA+K I+L DG I + LV PA +I+E E E F Sbjct 3 YSIGIDSGSTATKGILLADGV-ITRRFLVPT---PFRPATAITEAWETLREGLETTPFLT 58 Query 64 ATGYGRNSLEGIADKQMSELSCHAMGASFIWPNVHTVIDIGGQDVKVIHV-ENGTMTNFQ 122 TGYGR L ADKQ++E+SCH +GA F+ P VIDIGGQD KVI + ++G + +F Sbjct 59 LTGYGRQ-LVDFADKQVTEISCHGLGARFLAPATRAVIDIGGQDSKVIQLDDDGNLCDFL 117 Query 123 MNDKCAAGTGRFLDVMANILEVKVSDLAELGAKSTKRVAISSTCTVFAESEVISQLSKGT 182 MNDKCAAGTGRFL+V++ L V L + T AI+S CTVFAESE IS S G Sbjct 118 MNDKCAAGTGRFLEVISRTLGTSVEQLDSITENVTPH-AITSMCTVFAESEAISLRSAGV 176 Query 183 DKIDIIAGIHRSVASRVIGLANRVGIVKDVVMTGGVAQNYGVRGALEEGLGVEIKTSP 240 I+AG+ ++A R R+ ++ TGGV+ LE L + + T P Sbjct 177 APEAILAGVINAMARRSANFIARLSCEAPILFTGGVSHCQKFARMLESHLRMPVNTHP 234 >RecName: Full=Benzoyl-CoA reductase subunit A; AltName: Full=3-hydroxybenzoyl-CoA reductase subunit alpha [Thauera aromatica] Sequence ID: O87876.1 Length: 438 Range 1: 231 to 417 Score:148 bits(373), Expect:9e-41, Method:Compositional matrix adjust., Identities:78/187(42%), Positives:118/187(63%), Gaps:7/187(3%) Query 61 FTLATGYGRNSLEGIADKQMSELSCHAMGASFIWPNVHTVIDIGGQDVKVIHVEN-GTMT 119 + + TGYGR L + SE+ CH +GA ++P TV+DIGGQD K I +++ G + Sbjct 231 YVVGTGYGRVRLPFPKEHIRSEILCHGLGAHLMYPKTRTVLDIGGQDTKGIQIDDKGIVV 290 Query 120 NFQMNDKCAAGTGRFLDVMANILEVKVSDLAELGAKSTKRVAISSTCTVFAESEVISQLS 179 NFQMND+CAAGTGR+L +A+ + + + +L L KSTK + I+STCTVFA +E+ +L+ Sbjct 291 NFQMNDRCAAGTGRYLGYVADEMNMGLHELGPLAMKSTKSIRINSTCTVFAGAELRDRLA 350 Query 180 KGTDKIDIIAGIHRSVASRVIGLANRVGIVKD-VVMTGGVAQNYG----VRGALEEGLG- 233 G + DI+AG+HR++ R + + +R G + D TGGVA+N +R ++E G Sbjct 351 LGDKREDILAGLHRAIMLRAMSIISRSGGITDQFTFTGGVAKNEAAVKELRQLVKENYGE 410 Query 234 VEIKTSP 240 V+I P Sbjct 411 VQINIDP 417 >RecName: Full=Uncharacterized protein MJ0004 [Methanocaldococcus jannaschii DSM 2661] Sequence ID: Q60315.1 Length: 243 Range 1: 3 to 222 Score:138 bits(347), Expect:9e-39, Method:Compositional matrix adjust., Identities:88/229(38%), Positives:138/229(60%), Gaps:11/229(4%) Query 6 LGIDVGSTASKCIILKDGKEIVAK-SLVAVGTGTSGPARSISEVLENAHMKKEDMAFTLA 64 LGIDVGST +K ++++D K I K + V + + E+ + + K +A Sbjct 3 LGIDVGSTTTKMVLMEDSKIIWYKIEDIGVVIEEDILLKMVKEIEQKYPIDK-----IVA 57 Query 65 TGYGRNSLEGIADKQMSELSCHAMGASFIWPNVHTVIDIGGQDVKVIHVE-NGTMTNFQM 123 TGYGR+ + ADK + E+ GA++ + VIDIGGQD KV+ ++ NG + +F + Sbjct 58 TGYGRHKV-SFADKIVPEVIALGKGANYFFNEADGVIDIGGQDTKVLKIDKNGKVVDFIL 116 Query 124 NDKCAAGTGRFLDVMANILEVKVSDLAELGAKSTKRVAISSTCTVFAESEVISQLSKGTD 183 +DKCAAGTG+FL+ +IL++ +++ + KS ISS C VFAESE+IS LSK Sbjct 117 SDKCAAGTGKFLEKALDILKIDKNEINKY--KSDNIAKISSMCAVFAESEIISLLSKKVP 174 Query 184 KIDIIAGIHRSVASRVIGLANRVGIVKDVVMTGGVAQNYGVRGALEEGL 232 K I+ G++ S+ +RVI + NR+ I +++V +GGVA+N + E+ L Sbjct 175 KEGILMGVYESIINRVIPMTNRLKI-QNIVFSGGVAKNKVLVEMFEKKL 222 >RecName: Full=Benzoyl-CoA reductase subunit D; AltName: Full=3-hydroxybenzoyl-CoA reductase subunit delta [Thauera aromatica] Sequence ID: O87877.1 Length: 282 Range 1: 4 to 236 Score:100 bits(249), Expect:6e-24, Method:Compositional matrix adjust., Identities:72/237(30%), Positives:121/237(51%), Gaps:13/237(5%) Query 5 TLGIDVGSTASKCIILK---DGKEIVAKSLVAVGTGTSGPARSISE----VLENAHMKKE 57 T GID+G+ A K ++ + D E +AK + P + E +LE A +K Sbjct 4 TAGIDIGTGAVKTVLFRVEGDKTEWLAKRNDRIRQ--RDPFKLAEEAYNGLLEEAGLKAS 61 Query 58 DMAFTLATGYGRNSLEGIADKQMSELSCHAMGASFIWPNVHTVIDIGGQDVKVI-HVENG 116 D+ + TG G + ++ HA GA ++ P V+DIG + I + E G Sbjct 62 DVDYVATTGEGESL--AFHTGHFYSMTTHARGAVYLNPEARAVLDIGALHGRAIRNDERG 119 Query 117 TMTNFQMNDKCAAGTGRFLDVMANILEVKVSDLAELGAKSTKRVAISSTCTVFAESEVIS 176 + ++M +CA+G+G+FL+ +A L + ++ L ++ +SS C V AE++VI+ Sbjct 120 KVETYKMTSQCASGSGQFLENIARYLGIAQDEIGSLSTQADNPEVVSSICAVLAETDVIN 179 Query 177 QLSKGTDKIDIIAGIHRSVASRVIGLANRVGIVKDVVM-TGGVAQNYGVRGALEEGL 232 +S+G +I+ GIH S+A R+ L VG VV+ TGG+A + G+ L E + Sbjct 180 MVSRGISAPNILKGIHISMAGRLAKLLKSVGARDGVVLCTGGLALDEGLLKTLNESI 236 >RecName: Full=Uncharacterized protein MJ0800 [Methanocaldococcus jannaschii DSM 2661] Sequence ID: Q58210.1 Length: 415 Range 1: 150 to 387 Score:88.2 bits(217), Expect:8e-19, Method:Compositional matrix adjust., Identities:71/239(30%), Positives:120/239(50%), Gaps:8/239(3%) Query 5 TLGIDVGSTASKCIILKDGKEIVAKSLVAVGTGTSGPARSISEVLENAHMKKEDMAFTLA 64 +LGID GST +K +++ D E+ + +++ L+ A + + + Sbjct 150 SLGIDSGSTTTKAVVMID-DEVAGTGWIYTKDVIESAKEAVNNALKEAGISLDQVETIGT 208 Query 65 TGYGRNSLEGI--ADKQMSELSCHAMGASFIWPNVH---TVIDIGGQDVKVIHVENGTMT 119 TGYGR ++ AD EL+ ++ GA+++ TVIDIGG D K I + + Sbjct 209 TGYGRYTVGEYFKADLIQEELTVNSKGAAYLADKQEGEATVIDIGGMDNKAISLYDAIPD 268 Query 120 NFQMNDKCAAGTGRFLDVMANILEVKVSDLAELGAK-STKRVAISSTCTVFAESEVISQL 178 F M CA +GRF ++ A L V + +L EL AK +++ ++S C VF ++++ L Sbjct 269 GFTMGGICAGASGRFFEITARRLGVSLQELGELAAKGDWRKIKMNSYCIVFGIQDLVTAL 328 Query 179 SKGTDKIDIIAGIHRSVASRVIGLA-NRVGIVKDVVMTGGVAQNYGVRGALEEGLGVEI 236 ++G D+ A SVA +V V + V++ GG + G+ A+EE LG +I Sbjct 329 AEGAKAEDVAAAAAHSVAEQVFEQQLQEVDVRDPVILVGGSSLLKGLVIAMEEVLGRKI 387