ID   HBE_HUMAN      STANDARD;      PRT;   146 AA.
AC   P02100;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   18-APR-2006, entry version 63.
DE   Hemoglobin epsilon subunit (Hemoglobin epsilon chain) (Epsilon-
DE   globin).
GN   Name=HBE1; Synonyms=HBE;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=81064664; PubMed=6254663; DOI=10.1016/0092-8674(80)90425-0;
RA   Baralle F.E., Shoulders C.C., Proudfoot N.J.;
RT   "The primary structure of the human epsilon-globin gene.";
RL   Cell 21:621-626(1980).
RN   [2]
RP   PROTEIN SEQUENCE.
RX   MEDLINE=82108309; PubMed=6172865;
RA   Clegg J.B.;
RT   "Embryonic hemoglobin: sequence of the epsilon and zeta chains.";
RL   Tex. Rep. Biol. Med. 40:23-28(1981).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN   [4]
RP   X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF HB GOWER-2.
RX   MEDLINE=98332748; PubMed=9665850; DOI=10.1006/jmbi.1998.1868;
RA   Sutherland-Smith A.J., Baker H.M., Hofmann O.M., Brittain T.,
RA   Baker E.N.;
RT   "Crystal structure of a human embryonic haemoglobin: the carbonmonoxy
RT   form of Gower II (alpha2 epsilon2) haemoglobin at 2.9-A resolution.";
RL   J. Mol. Biol. 280:475-484(1998).
CC   -!- FUNCTION: The epsilon chain is a beta-type chain of early
CC       mammalian embryonic hemoglobin.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two epsilon chains
CC       in early embryonic hemoglobin Gower-2; two zeta chains and two
CC       epsilon chains in early embryonic hemoglobin Gower-1.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family.
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DR   EMBL; U01317; AAA16330.1; -; Genomic_DNA.
DR   EMBL; V00508; CAA23766.1; -; Genomic_DNA.
DR   EMBL; BC015537; AAH15537.1; -; mRNA.
DR   PIR; A90802; HEHU.
DR   UniGene; Hs.117848; -.
DR   PDB; 1A9W; X-ray; E/F=1-146.
DR   Ensembl; ENSG00000196565; Homo sapiens.
DR   H-InvDB; HIX0009389; -.
DR   HGNC; HGNC:4830; HBE1.
DR   MIM; 142100; gene.
DR   LinkHub; P02100; -.
DR   GO; GO:0005833; C:hemoglobin complex; TAS.
DR   GO; GO:0005344; F:oxygen transporter activity; TAS.
DR   InterPro; IPR002337; Beta_haem.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin_like.
DR   InterPro; IPR012292; Globin_related.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   PROSITE; PS01033; GLOBIN; 1.
KW   3D-structure; Direct protein sequencing; Heme; Iron; Metal-binding;
KW   Oxygen transport; Transport.
FT   INIT_MET      0      0
FT   CHAIN         1    146       Hemoglobin epsilon subunit.
FT                                /FTId=PRO_0000053212.
FT   METAL        63     63       Iron (heme distal ligand).
FT   METAL        92     92       Iron (heme proximal ligand).
FT   CONFLICT    142    142       A -> G (in Ref. 2).
FT   HELIX         5     12
FT   TURN         20     22
FT   HELIX        23     34
FT   STRAND       35     35
FT   HELIX        36     40
FT   TURN         41     42
FT   TURN         54     56
FT   HELIX        58     69
FT   HELIX        72     75
FT   TURN         76     77
FT   STRAND       78     80
FT   TURN         82     88
FT   HELIX        91     96
FT   TURN        100    100
FT   HELIX       101    121
FT   STRAND      122    122
FT   HELIX       124    134
FT   HELIX       137    141
FT   TURN        142    142
FT   STRAND      143    143
SQ   SEQUENCE   146 AA;  16072 MW;  6BE722E4BD6CD8D5 CRC64;
     VHFTAEEKAA VTSLWSKMNV EEAGGEALGR LLVVYPWTQR FFDSFGNLSS PSAILGNPKV
     KAHGKKVLTS FGDAIKNMDN LKPAFAKLSE LHCDKLHVDP ENFKLLGNVM VIILATHFGK
     EFTPEVQAAW QKLVSAVAIA LAHKYH
//