Analysis Type: PANTHER Overrepresentation Test (Released 20240226) Annotation Version and Release Date: GO Ontology database DOI: 10.5281/zenodo.10536401 Released 2024-01-17 Analyzed List: upload_1 (Homo sapiens) Reference List: Homo sapiens (all genes in database) Test Type: FISHER Correction: FDR GO biological process complete Homo sapiens - REFLIST (20592) upload_1 (36) upload_1 (expected) upload_1 (over/under) upload_1 (fold Enrichment) upload_1 (raw P-value) upload_1 (FDR) NADP biosynthetic process (GO:0006741) 2 2 .00 + > 100 2.97E-06 4.27E-04 protein depropionylation (GO:0106230) 2 2 .00 + > 100 2.97E-06 4.23E-04 peptidyl-lysine desuccinylation (GO:0036049) 2 2 .00 + > 100 2.97E-06 4.19E-04 protein desuccinylation (GO:0036048) 2 2 .00 + > 100 2.97E-06 4.16E-04 peptidyl-lysine demalonylation (GO:0036047) 2 2 .00 + > 100 2.97E-06 4.12E-04 protein demalonylation (GO:0036046) 2 2 .00 + > 100 2.97E-06 4.08E-04 protein deglutarylation (GO:0061698) 2 2 .00 + > 100 2.97E-06 4.04E-04 IMP catabolic process (GO:0006204) 5 4 .01 + > 100 3.93E-11 1.09E-08 pyridine nucleotide biosynthetic process (GO:0019363) 27 14 .05 + > 100 2.67E-33 4.07E-29 nicotinamide nucleotide biosynthetic process (GO:0019359) 27 14 .05 + > 100 2.67E-33 2.04E-29 dAMP catabolic process (GO:0046059) 4 2 .01 + > 100 1.78E-05 2.14E-03 dGMP catabolic process (GO:0046055) 4 2 .01 + > 100 1.78E-05 2.12E-03 dGMP metabolic process (GO:0046054) 6 3 .01 + > 100 9.78E-08 1.84E-05 purine deoxyribonucleoside monophosphate catabolic process (GO:0009172) 6 3 .01 + > 100 9.78E-08 1.82E-05 purine ribonucleoside monophosphate catabolic process (GO:0009169) 10 5 .02 + > 100 3.06E-12 1.01E-09 purine nucleoside monophosphate catabolic process (GO:0009128) 10 5 .02 + > 100 3.06E-12 9.93E-10 NAD biosynthetic process (GO:0009435) 25 12 .04 + > 100 5.31E-28 7.35E-25 protein deacetylation (GO:0006476) 15 7 .03 + > 100 1.71E-16 8.98E-14 pyridine-containing compound biosynthetic process (GO:0072525) 31 14 .05 + > 100 3.52E-32 1.07E-28 allantoin metabolic process (GO:0000255) 9 4 .02 + > 100 9.85E-10 2.42E-07 peptidyl-lysine deacetylation (GO:0034983) 7 3 .01 + > 100 1.71E-07 2.99E-05 adenosine metabolic process (GO:0046085) 10 4 .02 + > 100 1.64E-09 3.90E-07 AMP catabolic process (GO:0006196) 5 2 .01 + > 100 2.96E-05 3.34E-03 purine deoxyribonucleoside monophosphate metabolic process (GO:0009170) 11 4 .02 + > 100 2.57E-09 6.03E-07 dUMP catabolic process (GO:0046079) 6 2 .01 + > 100 4.44E-05 4.87E-03 ribonucleoside monophosphate catabolic process (GO:0009158) 15 5 .03 + > 100 3.63E-11 1.04E-08 nucleoside monophosphate catabolic process (GO:0009125) 19 6 .03 + > 100 4.91E-13 1.78E-10 purine deoxyribonucleotide catabolic process (GO:0009155) 10 3 .02 + > 100 5.84E-07 9.57E-05 NAD biosynthesis via nicotinamide riboside salvage pathway (GO:0034356) 10 3 .02 + > 100 5.84E-07 9.47E-05 protein deacylation (GO:0035601) 24 7 .04 + > 100 9.09E-15 3.75E-12 dUMP metabolic process (GO:0046078) 7 2 .01 + > 100 6.21E-05 6.57E-03 dAMP metabolic process (GO:0046053) 7 2 .01 + > 100 6.21E-05 6.52E-03 subtelomeric heterochromatin formation (GO:0031509) 7 2 .01 + > 100 6.21E-05 6.48E-03 rDNA heterochromatin formation (GO:0000183) 7 2 .01 + > 100 6.21E-05 6.44E-03 deoxyribonucleoside monophosphate catabolic process (GO:0009159) 14 4 .02 + > 100 7.78E-09 1.74E-06 purine ribonucleoside metabolic process (GO:0046128) 22 6 .04 + > 100 1.35E-12 4.56E-10 purine ribonucleoside biosynthetic process (GO:0046129) 12 3 .02 + > 100 1.07E-06 1.68E-04 nucleolar chromatin organization (GO:1990700) 8 2 .01 + > 100 8.27E-05 8.46E-03 purine ribonucleoside salvage (GO:0006166) 8 2 .01 + > 100 8.27E-05 8.40E-03 macromolecule deacylation (GO:0098732) 28 7 .05 + > 100 3.10E-14 1.21E-11 pyrimidine deoxyribonucleoside monophosphate catabolic process (GO:0009178) 8 2 .01 + > 100 8.27E-05 8.34E-03 purine deoxyribonucleotide metabolic process (GO:0009151) 16 4 .03 + > 100 1.41E-08 2.90E-06 ribonucleoside biosynthetic process (GO:0042455) 12 3 .02 + > 100 1.07E-06 1.66E-04 purine nucleoside biosynthetic process (GO:0042451) 12 3 .02 + > 100 1.07E-06 1.64E-04 NAD metabolic process (GO:0019674) 62 15 .11 + > 100 1.28E-29 2.17E-26 IMP metabolic process (GO:0046040) 18 4 .03 + > 100 2.37E-08 4.74E-06 constitutive heterochromatin formation (GO:0140719) 9 2 .02 + > 100 1.06E-04 1.02E-02 pyrimidine nucleoside monophosphate catabolic process (GO:0009131) 9 2 .02 + > 100 1.06E-04 1.02E-02 purine nucleoside metabolic process (GO:0042278) 27 6 .05 + > 100 5.31E-12 1.69E-09 deoxyribonucleoside monophosphate metabolic process (GO:0009162) 24 5 .04 + > 100 5.07E-10 1.31E-07 purine-containing compound salvage (GO:0043101) 16 3 .03 + > 100 2.71E-06 3.93E-04 pyrimidine deoxyribonucleoside monophosphate metabolic process (GO:0009176) 11 2 .02 + > 100 1.62E-04 1.49E-02 positive regulation of gluconeogenesis (GO:0045722) 18 3 .03 + 95.33 3.93E-06 5.30E-04 nucleoside triphosphate catabolic process (GO:0009143) 12 2 .02 + 95.33 1.94E-04 1.78E-02 ribonucleoside metabolic process (GO:0009119) 36 6 .06 + 95.33 3.45E-11 1.01E-08 nucleoside salvage (GO:0043174) 13 2 .02 + 88.00 2.29E-04 2.08E-02 negative regulation of glucose import (GO:0046325) 13 2 .02 + 88.00 2.29E-04 2.07E-02 nucleoside biosynthetic process (GO:0009163) 20 3 .03 + 85.80 5.48E-06 7.26E-04 nucleobase-containing small molecule biosynthetic process (GO:0034404) 20 3 .03 + 85.80 5.48E-06 7.20E-04 deoxyribonucleotide catabolic process (GO:0009264) 28 4 .05 + 81.71 1.56E-07 2.84E-05 deoxyribose phosphate catabolic process (GO:0046386) 28 4 .05 + 81.71 1.56E-07 2.80E-05 DNA repair-dependent chromatin remodeling (GO:0140861) 22 3 .04 + 78.00 7.39E-06 9.54E-04 pyridine-containing compound metabolic process (GO:0072524) 126 17 .22 + 77.17 6.01E-29 9.15E-26 pyridine nucleotide metabolic process (GO:0019362) 119 16 .21 + 76.91 3.60E-27 4.58E-24 nicotinamide nucleotide metabolic process (GO:0046496) 119 16 .21 + 76.91 3.60E-27 4.22E-24 nucleolus organization (GO:0007000) 15 2 .03 + 76.27 3.08E-04 2.68E-02 2'-deoxyribonucleotide metabolic process (GO:0009394) 41 5 .07 + 69.76 8.76E-09 1.93E-06 purine ribonucleoside monophosphate metabolic process (GO:0009167) 41 5 .07 + 69.76 8.76E-09 1.91E-06 deoxyribonucleotide metabolic process (GO:0009262) 42 5 .07 + 68.10 9.93E-09 2.13E-06 deoxyribose phosphate metabolic process (GO:0019692) 42 5 .07 + 68.10 9.93E-09 2.10E-06 purine nucleoside monophosphate metabolic process (GO:0009126) 43 5 .08 + 66.51 1.12E-08 2.34E-06 glycosyl compound biosynthetic process (GO:1901659) 26 3 .05 + 66.00 1.24E-05 1.56E-03 pyrimidine deoxyribonucleotide catabolic process (GO:0009223) 18 2 .03 + 63.56 4.47E-04 3.72E-02 negative regulation of glucose transmembrane transport (GO:0010829) 18 2 .03 + 63.56 4.47E-04 3.70E-02 NADP metabolic process (GO:0006739) 38 4 .07 + 60.21 5.57E-07 9.22E-05 nucleoside metabolic process (GO:0009116) 58 6 .10 + 59.17 6.98E-10 1.74E-07 phosphate ion homeostasis (GO:0055062) 20 2 .03 + 57.20 5.54E-04 4.51E-02 cellular metabolic compound salvage (GO:0043094) 34 3 .06 + 50.47 2.83E-05 3.24E-03 ribonucleoside monophosphate metabolic process (GO:0009161) 62 5 .11 + 46.13 7.36E-08 1.40E-05 regulation of gluconeogenesis (GO:0006111) 50 4 .09 + 45.76 1.71E-06 2.58E-04 nucleoside monophosphate metabolic process (GO:0009123) 79 6 .14 + 43.44 4.67E-09 1.08E-06 nucleoside phosphate catabolic process (GO:1901292) 134 10 .23 + 42.69 2.13E-14 8.55E-12 positive regulation of glucose metabolic process (GO:0010907) 41 3 .07 + 41.85 5.00E-05 5.36E-03 purine-containing compound biosynthetic process (GO:0072522) 240 17 .42 + 40.52 5.38E-24 5.13E-21 glycosyl compound metabolic process (GO:1901657) 85 6 .15 + 40.38 7.29E-09 1.66E-06 purine nucleotide catabolic process (GO:0006195) 101 7 .18 + 39.64 4.11E-10 1.08E-07 negative regulation of reactive oxygen species metabolic process (GO:2000378) 44 3 .08 + 39.00 6.19E-05 6.59E-03 purine-containing compound catabolic process (GO:0072523) 107 7 .19 + 37.42 6.18E-10 1.57E-07 nucleotide catabolic process (GO:0009166) 125 8 .22 + 36.61 3.86E-11 1.09E-08 purine nucleotide biosynthetic process (GO:0006164) 230 14 .40 + 34.82 9.65E-19 6.39E-16 negative regulation of fat cell differentiation (GO:0045599) 52 3 .09 + 33.00 1.02E-04 9.99E-03 circadian regulation of gene expression (GO:0032922) 70 4 .12 + 32.69 6.64E-06 8.65E-04 nucleotide biosynthetic process (GO:0009165) 269 15 .47 + 31.90 1.62E-19 1.37E-16 pyridine-containing compound catabolic process (GO:0072526) 54 3 .09 + 31.78 1.14E-04 1.08E-02 nucleoside phosphate biosynthetic process (GO:1901293) 271 15 .47 + 31.66 1.81E-19 1.46E-16 purine ribonucleotide catabolic process (GO:0009154) 92 5 .16 + 31.09 5.39E-07 9.03E-05 organophosphate catabolic process (GO:0046434) 186 10 .33 + 30.75 5.88E-13 2.08E-10 pyrimidine nucleotide metabolic process (GO:0006220) 56 3 .10 + 30.64 1.28E-04 1.19E-02 regulation of carbohydrate biosynthetic process (GO:0043255) 97 5 .17 + 29.48 7.02E-07 1.13E-04 purine nucleotide metabolic process (GO:0006163) 466 24 .81 + 29.46 1.76E-31 3.35E-28 ribonucleotide catabolic process (GO:0009261) 99 5 .17 + 28.89 7.77E-07 1.23E-04 purine-containing compound metabolic process (GO:0072521) 498 25 .87 + 28.71 1.00E-32 5.09E-29 nucleotide metabolic process (GO:0009117) 529 25 .92 + 27.03 4.62E-32 1.17E-28 nucleoside phosphate metabolic process (GO:0006753) 537 25 .94 + 26.63 6.76E-32 1.47E-28 positive regulation of insulin secretion (GO:0032024) 87 4 .15 + 26.30 1.58E-05 1.94E-03 peptidyl-lysine modification (GO:0018205) 131 6 .23 + 26.20 9.84E-08 1.81E-05 nucleobase-containing small molecule metabolic process (GO:0055086) 608 26 1.06 + 24.46 1.91E-32 7.29E-29 regulation of glucose metabolic process (GO:0010906) 98 4 .17 + 23.35 2.53E-05 2.94E-03 positive regulation of carbohydrate metabolic process (GO:0045913) 74 3 .13 + 23.19 2.92E-04 2.57E-02 regulation of muscle cell apoptotic process (GO:0010660) 75 3 .13 + 22.88 3.04E-04 2.66E-02 heterochromatin formation (GO:0031507) 79 3 .14 + 21.72 3.54E-04 3.02E-02 negative regulation of gene expression, epigenetic (GO:0045814) 113 4 .20 + 20.25 4.42E-05 4.88E-03 positive regulation of peptide hormone secretion (GO:0090277) 114 4 .20 + 20.07 4.58E-05 4.98E-03 pyrimidine-containing compound metabolic process (GO:0072527) 86 3 .15 + 19.95 4.55E-04 3.75E-02 regulation of reactive oxygen species metabolic process (GO:2000377) 145 5 .25 + 19.72 5.11E-06 6.83E-04 positive regulation of peptide secretion (GO:0002793) 116 4 .20 + 19.72 4.90E-05 5.30E-03 positive regulation of lipid biosynthetic process (GO:0046889) 87 3 .15 + 19.72 4.70E-04 3.85E-02 ATP metabolic process (GO:0046034) 162 5 .28 + 17.65 8.77E-06 1.12E-03 regulation of fat cell differentiation (GO:0045598) 132 4 .23 + 17.33 8.10E-05 8.35E-03 nucleobase-containing compound catabolic process (GO:0034655) 336 10 .59 + 17.02 2.04E-10 5.46E-08 circadian rhythm (GO:0007623) 137 4 .24 + 16.70 9.36E-05 9.27E-03 cellular nitrogen compound catabolic process (GO:0044270) 378 11 .66 + 16.65 2.75E-11 8.38E-09 regulation of insulin secretion (GO:0050796) 172 5 .30 + 16.63 1.17E-05 1.49E-03 heterocycle catabolic process (GO:0046700) 379 11 .66 + 16.60 2.83E-11 8.45E-09 positive regulation of small molecule metabolic process (GO:0062013) 138 4 .24 + 16.58 9.63E-05 9.47E-03 regulation of cellular ketone metabolic process (GO:0010565) 141 4 .25 + 16.23 1.05E-04 1.02E-02 organophosphate biosynthetic process (GO:0090407) 551 15 .96 + 15.57 7.09E-15 3.09E-12 positive regulation of hormone secretion (GO:0046887) 147 4 .26 + 15.56 1.23E-04 1.16E-02 regulation of carbohydrate metabolic process (GO:0006109) 185 5 .32 + 15.46 1.67E-05 2.03E-03 positive regulation of protein secretion (GO:0050714) 148 4 .26 + 15.46 1.26E-04 1.18E-02 purine ribonucleoside triphosphate metabolic process (GO:0009205) 186 5 .33 + 15.38 1.71E-05 2.07E-03 carbohydrate derivative catabolic process (GO:1901136) 224 6 .39 + 15.32 2.30E-06 3.37E-04 organophosphate metabolic process (GO:0019637) 942 25 1.65 + 15.18 8.81E-26 8.95E-23 ribonucleoside triphosphate metabolic process (GO:0009199) 193 5 .34 + 14.82 2.04E-05 2.42E-03 purine nucleoside triphosphate metabolic process (GO:0009144) 193 5 .34 + 14.82 2.04E-05 2.40E-03 organic cyclic compound catabolic process (GO:1901361) 427 11 .75 + 14.74 1.01E-10 2.75E-08 aromatic compound catabolic process (GO:0019439) 399 10 .70 + 14.34 1.08E-09 2.62E-07 regulation of peptide hormone secretion (GO:0090276) 205 5 .36 + 13.95 2.73E-05 3.15E-03 regulation of peptide secretion (GO:0002791) 208 5 .36 + 13.75 2.93E-05 3.33E-03 nucleoside triphosphate metabolic process (GO:0009141) 209 5 .37 + 13.68 3.00E-05 3.36E-03 regulation of peptide transport (GO:0090087) 210 5 .37 + 13.62 3.07E-05 3.41E-03 purine ribonucleotide metabolic process (GO:0009150) 384 9 .67 + 13.41 1.50E-08 3.05E-06 regulation of lipid biosynthetic process (GO:0046890) 175 4 .31 + 13.07 2.40E-04 2.15E-02 ribonucleotide metabolic process (GO:0009259) 406 9 .71 + 12.68 2.42E-08 4.80E-06 regulation of small molecule metabolic process (GO:0062012) 324 7 .57 + 12.36 1.26E-06 1.92E-04 ribose phosphate metabolic process (GO:0019693) 420 9 .73 + 12.26 3.24E-08 6.34E-06 epigenetic regulation of gene expression (GO:0040029) 192 4 .34 + 11.92 3.42E-04 2.94E-02 nucleobase-containing compound biosynthetic process (GO:0034654) 938 19 1.64 + 11.59 1.12E-16 6.11E-14 regulation of hormone secretion (GO:0046883) 262 5 .46 + 10.92 8.76E-05 8.79E-03 regulation of protein secretion (GO:0050708) 265 5 .46 + 10.79 9.25E-05 9.21E-03 heterocycle biosynthetic process (GO:0018130) 1014 19 1.77 + 10.72 4.70E-16 2.39E-13 aromatic compound biosynthetic process (GO:0019438) 1024 19 1.79 + 10.61 5.62E-16 2.76E-13 small molecule metabolic process (GO:0044281) 1640 29 2.87 + 10.11 5.20E-26 5.66E-23 organic cyclic compound biosynthetic process (GO:1901362) 1150 19 2.01 + 9.45 4.68E-15 2.10E-12 regulation of lipid metabolic process (GO:0019216) 319 5 .56 + 8.97 2.20E-04 2.01E-02 phosphate-containing compound metabolic process (GO:0006796) 1711 25 2.99 + 8.36 2.02E-19 1.54E-16 phosphorus metabolic process (GO:0006793) 1737 25 3.04 + 8.23 2.91E-19 2.11E-16 negative regulation of phosphate metabolic process (GO:0045936) 365 5 .64 + 7.84 4.08E-04 3.46E-02 negative regulation of phosphorus metabolic process (GO:0010563) 366 5 .64 + 7.81 4.14E-04 3.48E-02 regulation of protein transport (GO:0051223) 442 6 .77 + 7.76 1.07E-04 1.02E-02 organonitrogen compound biosynthetic process (GO:1901566) 1360 17 2.38 + 7.15 2.03E-11 6.30E-09 cellular nitrogen compound biosynthetic process (GO:0044271) 1539 19 2.69 + 7.06 8.92E-13 3.09E-10 carbohydrate derivative metabolic process (GO:1901135) 1005 12 1.76 + 6.83 7.22E-08 1.39E-05 peptidyl-amino acid modification (GO:0018193) 529 6 .92 + 6.49 2.83E-04 2.50E-02 regulation of establishment of protein localization (GO:0070201) 541 6 .95 + 6.34 3.19E-04 2.76E-02 regulation of hormone levels (GO:0010817) 550 6 .96 + 6.24 3.48E-04 2.98E-02 cellular catabolic process (GO:0044248) 1132 12 1.98 + 6.06 2.63E-07 4.50E-05 nucleobase-containing compound metabolic process (GO:0006139) 2743 29 4.80 + 6.05 1.15E-19 1.03E-16 heterocycle metabolic process (GO:0046483) 2931 29 5.12 + 5.66 7.42E-19 5.14E-16 organonitrogen compound catabolic process (GO:1901565) 1126 11 1.97 + 5.59 2.11E-06 3.12E-04 cellular aromatic compound metabolic process (GO:0006725) 2971 29 5.19 + 5.58 1.08E-18 6.89E-16 organic cyclic compound metabolic process (GO:1901360) 3226 29 5.64 + 5.14 1.08E-17 6.35E-15 cellular nitrogen compound metabolic process (GO:0034641) 3288 29 5.75 + 5.05 1.84E-17 1.04E-14 negative regulation of protein metabolic process (GO:0051248) 810 7 1.42 + 4.94 4.37E-04 3.66E-02 organic substance catabolic process (GO:1901575) 1635 13 2.86 + 4.55 1.93E-06 2.89E-04 organonitrogen compound metabolic process (GO:1901564) 4671 33 8.17 + 4.04 1.71E-18 1.04E-15 catabolic process (GO:0009056) 1938 13 3.39 + 3.84 1.27E-05 1.58E-03 cellular biosynthetic process (GO:0044249) 3866 21 6.76 + 3.11 1.57E-07 2.78E-05 cellular metabolic process (GO:0044237) 6416 34 11.22 + 3.03 1.75E-15 8.08E-13 organic substance biosynthetic process (GO:1901576) 3964 21 6.93 + 3.03 2.45E-07 4.24E-05 biosynthetic process (GO:0009058) 4016 21 7.02 + 2.99 3.08E-07 5.22E-05 nitrogen compound metabolic process (GO:0006807) 6426 33 11.23 + 2.94 4.69E-14 1.79E-11 negative regulation of cellular metabolic process (GO:0031324) 2572 13 4.50 + 2.89 2.47E-04 2.20E-02 primary metabolic process (GO:0044238) 6944 35 12.14 + 2.88 6.87E-16 3.27E-13 organic substance metabolic process (GO:0071704) 7437 35 13.00 + 2.69 7.35E-15 3.11E-12 metabolic process (GO:0008152) 7979 35 13.95 + 2.51 8.33E-14 3.10E-11 cellular process (GO:0009987) 14948 36 26.13 + 1.38 1.49E-05 1.84E-03